                         SEQUENCE LISTING

<110>  Pioneer Hi-Bred International Inc.
       Cigan, Andrew  Mark
       King, Matt
       Lin, Helen
       Young, Joshua K
 
<120>  NOVEL CAS9 SYSTEMS AND METHODS OF USE

<130>  BB2554 PCT

<150>  62/306926
<151>  2016-03-11

<150>  62/370858
<151>  2016-08-04

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  5185
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 1 (Bacillus species)

<400>  1
ataaggtaaa ttaattcata ttgatatgta ggtgaaacaa atagaaaata aagagcctaa       60
acaataatac gatctaagta aaatatacac atataaagag ttccctgata ataaaattag      120
cggtcgttgc gataattgcg gcaatacctc attcaagagt tccgttaaag atttcatctt      180
tttaagagaa tgtcgtcaat gcggtatgaa gaaaatcata tagccctatc cagggctttt      240
ttctttgtgt aaatggaagt aaacttttgg gtaaaagaga aggtgcatgt attgtaactg      300
aattgttacc tctctatcct tcctaaaata ataagcatgg cgccatagta ttgattaagc      360
gatgtagaga ctaaagaaaa ctaaataaaa tcttcatttg aacagagaga gcccccttat      420
aagaaaataa ggggatatca gaatagtaca taaaacttgt agaactccaa tatgggaact      480
ctatattagt ttaacatgta ttaaagggaa ttttgaaaat caacaaaata taggataact      540
cgctctatat aggttgaaaa ataaaaaaca aaaaagcctg taagcgttga tattacagac      600
ctttttgaat acgtatcata atacagcaat ggcattaatg gaactatgac taggagggat      660
tgcatgaaga aagtaacaaa attataatac agcaatggct taaatagaac tatgattaat      720
gattttcgct ctaaatcaca gaggatatta taccagattt ctgttgtttt tctgaaaacc      780
acccttgtct tcatattttt tatttgaaaa atcagatatt ttcgttataa tagagatatc      840
ataatacagc aatggctttg atgtttctat gataagggct taggcccgtg gcgttgggga      900
tcgcctgccc attttaatgg gcttctcccc acctatttaa tgagaatttt acaaccttgg      960
ctattcttaa atagctaagg tttttttgta tacatataaa ttaatagagg tgagattatg     1020
agagagttgg attatcgcat aggattagat attggaacga attctattgg ctgggggatc     1080
attgaattat cttggaacaa agatagagaa caatatgaga aagcaagaat tgtcgacaag     1140
ggtgttcgta tgtttgataa ggctgaaata cctaagactg gtgcttctct tgctgaaccg     1200
aggcgtttag cgcgctcatc acgtagaaga ttaaatcgca aaagccagag aaaaaaagat     1260
atacgtaatt tacttgttca acatgaaatt attagtcaaa gggaattggc ttcgttatat     1320
cccctgtcaa aaagttcaat ggatatttgg gatattcgat tggagggatt agatcgcttg     1380
ttagaccatt ttgaatggac tcgattatta attcatttag cgcaaaggcg cggttttaaa     1440
tcaaatcgga agtctgaatt gaaagatgtg gagacaggaa aagtattatc aagtattcaa     1500
gcaaatgaaa aacgattatc actgtaccgt acagtgggag agatgtggat gaagaatgaa     1560
gattttagta aatatgacaa aaggcgtaat tctcctaatg agtatgtatt ttcggttagc     1620
cgtgcagatt tagaaaaaga aattgtgact ctatttgaag cgcaaagaaa atttcagtca     1680
tcatatgcat cggttgattt acaaaaaaca tacttacaaa tttgggcaca ccaacttcct     1740
tttgcttctg ggaatgcaat tgtaaataaa gtgggatatt gttcattatt aaaaggtaaa     1800
gaaaagagag ttccgaaagc aacatatact tttcaatatt tcagtacact agatcaaata     1860
aatcgaacac gattaggtcc taatttccaa ccatttacga aggaacagag agacattatt     1920
ttagataaaa tgtttaatcg aacagattat tataaaaaaa agacaatacc cgaagttact     1980
tactatgata ttcggaaatg gttagcatta gatgaaacaa ttcaatttaa aggacttacc     2040
tatgacccaa atgaagagct gaaaaaaata gaattgaaat cctttattaa tttaaagcca     2100
ttttatgaaa ttaaacaggt agttactaat tacgccaaga aaataaatga ggcattctca     2160
acattagact atgatacatt tgcatatgct ttaacagttt ataaaacgga caaagatatt     2220
agatcttatt taaagaaatc taataattta tcaaaatgtt gctacgatga tcaattaata     2280
gaagagctat taactctctc ctatacaaag tttggtcatt tatcatttaa agcaattaat     2340
catgtactgc caattatgca agagggaagg acttatcagg aagcaataca ccaattagga     2400
tatgatacca ctaatctaaa aaaagaaaac agaagtatgt tcttgcccct tattcccgat     2460
gagataacaa atccaattgt taaaagagca ctaactcaag cacgtaaagt tgtaaatgct     2520
attattagaa gatatggttc cccaaattct gttcatattg aactagcccg tgagcttcct     2580
aaaaatcatg atgagagaac gaaaataatg aaagctcatg atgaaaatta taagaaaaat     2640
aaaggagcca tatcaatttt gattgagaat ggaattttaa atccgacagg atatgatatt     2700
gtacgttata agttatggaa agagcaagga gagcgatgtg tttattcgct aaaacagatt     2760
cctgctaata cgttttttaa tgaattgaaa aaagagcgaa gtggcccccc ggttctagag     2820
atagatcaca ttttaccgta tagtcagagt tttattgata gttatcataa taaagtacta     2880
gtttatgagg aggagaatca aaaaaaggga aatcgaattc catatactta ttttttagaa     2940
gaaaataagg actgggaaag cttcgaaagc tacgtacgat tgaatagttt tttgtctaaa     3000
aagaagcgcg gatatttatt gaaaaaagct tacttgccaa gagagagtaa catgattaag     3060
gagcgtcatt taaatgatac tcgatatgct agtagctatc tgaaaaactt cattgagaaa     3120
aatttgaaat ttaaagaagt tgaaggtagt acaagaaaca aacatgtaca gacggttaac     3180
ggtataatta cagcccatct gcgaaaaaga tggggattag aaaaagatag gaaggaaaca     3240
tatttgcatc atgcaatgga cgctattatt gttgcttgta cagaccatca tatggttact     3300
aaagtaacgg agtactatca aataaaagaa agtaataagt caataaagaa accatacttt     3360
cctttgccat gggtgggctt tagagaggaa attttatcac atttagcaag gcaaccaatt     3420
gctagaaaaa ttagtgagga acttaaaatt ggatatcaat catttgatta tatacttgta     3480
tcgcgaatgc caaaaagatc tgtcactgga tcagctcatg aacagacaat catgaaaaaa     3540
ggtggtatcg acaaaaaagg taaaactatt atcataaagc gtgtgtactt aaaggatatt     3600
aagtttgatg agaatggcga ttttaaaatg gttggaaaag aacaagattt agcaacttat     3660
gaagcgataa agcaaagata tatagagtat ggaaaagaat cgaagaaagc atttgaaaca     3720
cctttataca agcctagtaa aaaaggaaaa ggaaacctca ttaaaaagat caaagtagaa     3780
gtgcaaacca aatcttttgt tcgagaagtt aatggaggcg tagctcaaaa tggtgattta     3840
gtaagagtag atttgtttga aaaggataat agatattata tggtacctat ttatgtaatg     3900
gatactgttc attccgaact accaaataaa gctgtaacaa gcagtaaagg ctatgagcaa     3960
tggttaacaa tagataacag ctttacgttc aaattcagtt tatatcctta tgatttagta     4020
cgacttgtaa aaggtgatga agatcgtttc ctatatttta gtacccttga tattaattcg     4080
gatcgtctta atttcaaaga tgtaaacacg ccatcaaagc aggctgaaaa tcgttatagc     4140
cttaaaacaa ttgagaattt agaaaaatat gaggttggtg ttttaggtga tttaaggttt     4200
gtgagacaag aaatacgtaa aaatttttaa tagataaaaa ttagcggaat ttttatacgg     4260
taagcaatat tagcttgttc accgtattat aaaaaacaaa aaagcctgta agcgttgatg     4320
ttataggctt ttttgaatac gtatcataat acagcaatgg cttaaatgga actatgacca     4380
ggccaagaag tggaagggtt gtgaagcgat cataatacag caatggctta aatggaacta     4440
tcacgtccga acaaactacg tcatcaatac ctttatcata atacagcaat agctttaatg     4500
gaactatgac acaaatgtgg acaaccagtc atcatataca atcataatac agaaatggct     4560
ttaatgggac tatgacaaat acgatcaatt acatctagac tttgtcatca taatacagaa     4620
atggcttaaa tggaactatg gcacgccttt tggtatggta aaaataatct ccatcataat     4680
acggaaatgg ccttaatgga attatgactt tatctggaat tatcgttcca aaaaaatatc     4740
ataacacagc taaaaaatac aataataagt tcagtatagc gctatgctac ttttcgccgg     4800
gtttatttct atcatttgaa tttgaaatat atctctatcc tctattccca agacacgcat     4860
ttcttcttta aatgaacgcc agggttcaat cttaatagat ttagtagttt tatctattag     4920
cgtatactca tgtacataat atgatttttc atttttgctc attttaattt ttccaaacct     4980
ccttaaaaca actgaaaaac tttaggtgta taaaaattac atattaagtg ctggttttta     5040
attaatgttt atttggtatt gcttatagta attgtaatat ctttttaagg ataagtgaga     5100
cttaaagccg atttgctgca taatttgttc aggattattt ttctgtttaa ttttacttaa     5160
aataaaggtg tttcggaaat gttga                                           5185

<210>  2
<211>  5630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 2 (Bacillus species)

<220>
<221>  misc_feature
<222>  (4480)..(4481)
<223>  n is a, c, g, or t

<400>  2
tacataaaac ttgtagaact ccaatatggg aactctatat tagtttaacg cgtatgaaag       60
agaaggtgga tgtattgtaa ctgaattgtt acttctctat ccttcctaaa aataataagc      120
atggcgctat agcattgatt aagtgatgga aagattaaag acaacaaaac aaaatcttca      180
tttgaaaaga gaaagccccc ttataagaaa ataagggggt tgaggtagaa taaagtaaac      240
gtcgactcga actccaaacc agcggagctt ctaagttagt ttaacacgta tgaaagagaa      300
ggtggatgta ttgtaatcga attgttaccc ctctgtcctt ccttaaaata ataaaaatcc      360
tttatgtata tagaaattat atgtttttga aaaccgataa aatatagggt aactcactct      420
atataggttg aaaagtaaaa atgaaaaacc ctgtaagcgt tgatattaca gggttttttg      480
aatacgtatc ataaaacagc aatggctaaa atggaactat gacaccactg tttgttgtgt      540
tgctccactt gcaatcataa aacagcaatg gctttaatgg gactatgact aggagggatt      600
gcatgaagaa agtaacaaaa ttataaaaca gcaatggcta aaatggaacc ataattaatg      660
attttcgctc taaatcacag aggatattat agcagatctc tgttgttttt ctgaaaacta      720
cccttgtctc catggattta tttgaaaaat tcgacatttt ttgttataat agggatatca      780
taaaacagca atggctttga tgtttctatg ataagggctt aggcccgtgg cgttggggat      840
cgcctgccca tttttatggg cttctcccca tctatttaat gaaaatttta caaccttggc      900
tattcttaaa tagctaaggt ttttttgtat acatataaac taatagaggt gagattatga      960
gagagttgga ttatcgcata ggattagata ttggaacgaa ttctattggc tggggtgttg     1020
ttgaattatc ttggaacaaa gatagagaac aatatgagaa agcaagaatt gtcgacaagg     1080
gtgttcgtat gtttgataag gctgaaatac ctaaaactgg tgcttctctt gctgaaccga     1140
ggcgtacagc gcgttcatca cgtagaaggt taaatcgcaa aagccagaga aaaaaagata     1200
tacgtaattt acttgttcaa catgaaatta ttagtcaaaa ggaattggct tcgttatatc     1260
ccctgtcaaa aagttcaatg gatatttggg atattcgatt ggatgggtta gatcgcttgt     1320
tagaccgtct tgaatggact cgattattaa ttcatttagc acaaaagcgc ggttttaaat     1380
caaatcgaaa gtctgaactg aaagatgtgg agacaggaaa agtattatca agtattcaag     1440
taaatgaaaa acgattatca ctgtaccgta cagtgggaga gatgtggatg aagaatgaag     1500
attttagtaa atatgacaaa aggcgtaatt ctcctaatga gtatgtattt tcggttagcc     1560
gtgcaaattt agaaaaagaa attgtgactc tatttgaagc gcaaagaaaa tttcagtcat     1620
catatgcatc agttgattta caaaaaacat acttacaaat ttgggcacat caacttcctt     1680
ttgcttctgg gaatgcaatt gtaaataaag taggatattg ttcattatta aaagggaaag     1740
aaaagagagt tccgaaagca acatatactt ttcaatattt tagtacacta gatcaaataa     1800
accgaacacg attaggacct aatttccaac catttacgaa ggaacagaga gacataatct     1860
tagataaaat gtttcaacgg acagattatt ataaaaaaaa gacaataccc gaagttactt     1920
actatgatat tcggaaatgg ttagcactag atgaaacaat tcaatttaaa ggacttacct     1980
atgacccaaa cgaagagctg aaaaaaatag aaatgaaact ctttataaat ttaaagccat     2040
tttatgaaat taaaaaggta gttactaatt acgcaaaaaa aacaaatgag gtattctcaa     2100
cattagacta tgatacagtt gcatacgctt taacagttta taaaacggac aaagatatta     2160
tatcttattt gaagagatct aataatttat caaaacgttg ttacgatgat caattaatag     2220
aagagctatt aactctttcc tatacaaagt ttggtcattt atcatttaaa gccattaatc     2280
atgtactgcc aattatgcaa gagggaagga cttatcagga agcaatacac caattaggat     2340
atgataccac taatctaaaa aaagaaaaca gaagtatgtt cttgcccctt attccagatg     2400
agataacaaa tccaattgtt aaaagagcac taactcaagc acgtaaagtt gtaaatgcta     2460
ttattagaag atatggttcc cccaattctg ttcatattga actagctcgt gagctttcta     2520
aaactcatga tgagagaacg aaaataatga aagctcatga tgaaaattat aagaaaaata     2580
aaggagccat atcaattttg attgagaatg gaattttaaa tccgacagga tatgatattg     2640
tacgttataa gttatggaaa gagcaaggag aacgatgtgc ttattcgcta aaacagattc     2700
atgctaatac gttttttaat gaattgaaaa aagagcgaag tggtccccca gttctagaga     2760
tagatcacat tttaccgtat agtcagagtt ttattgatag ttatcataat aaagtactag     2820
tttatgggga tgagaatcaa aaaaagggaa atcgaattcc atatacttat tttttagaag     2880
gaaataagga ctgggaaagc tttgaaagct acgtacgatt gaatagttta ttttctaaaa     2940
agaagcgcgg atatttattg aaaaaagctt acttgccaag agagagtaac atgattaagg     3000
agcgtcattt aaatgatact cgatatgcta gtagctattt gaaaaacttc attgagaaaa     3060
atttgaaatt taaagaagtc gaaggtagta cacgaaaaaa acatgtacag acggttaacg     3120
gtataattac agcccatctg cgaaaaagat ggggattaga aaaagataga caggaaacat     3180
atttgcatca tgcaatggac gctattatcg ttgcttgtac agaccatcat atggtcacta     3240
aagtaacgga gtactatcaa ataaaagaaa gtaataagtc aataaagaaa ccatactttc     3300
ctttgccatg ggtggccttt agagaggaaa ttttatcaca tttagcaagg cagccaattg     3360
ctagaaaaat tagtgaggaa cttaaaattg gatatcaatc atttgattat atacttgtat     3420
cgcgaatgcc aaaaagatct gtcactggag cagctcatga acagacaatc atgaaaaaag     3480
gtggtatcga taaaaaagga aagacaatta tcataaagcg tgtgtactta aaggatatta     3540
agtttgatga gaatggcgat tttaaaatgg ttggaaaaga acaggattta gcaacttatg     3600
aagcgataaa gcaaagatat atagagtatg gaaaagaatc gaaaaaagca tttgaaacac     3660
ctttatacaa gcctagtaaa aaaggaaaag ggaacctcat taaaaagatc aaagtagaag     3720
tgcaaaccaa atcttttgtt cgagaagtta atggaggcgt agctcaaaat ggtgatttag     3780
taagagtaga tttgtttgaa aaagataata gatattatat ggtacctatt tatgtaatgg     3840
atactgttca ttccgaacta ccaaataaag ctgtaacaag cagtaaaggc tatgagaaat     3900
ggttaacaat agataacagc tttacgttca aattcagttt atatccttat gatttagtac     3960
gacttgtaaa aggtgatgaa gatcgtttcc tatattttag tacccttgat attaattcgg     4020
atcgtcttaa tttcaaagat gtaaacaagc catcaaagca ggctgaaaat cgttatagcc     4080
ttaaaacaat tgagaattta gaaaaatatg aggttggtgt tttaggtgat ttaaggtttg     4140
tgagacaaga aatacgtaaa aatttttaat agataaaaat tagcttaatt ttaatacggt     4200
aagcaatatt agcttgttca ccgtattata aaaaacaaaa aagcctgtaa gcgttgatga     4260
tataggcttt tttgaatacg tatcataata cagtaatggc ttaaatggaa ctatcacgtc     4320
cgaacaaact acgtcatcaa tacctttatc ataatacagc aatagcttta atggagctat     4380
gacaagtttg cattccgacc taaaacagat ggaatcataa tacagcaatg gcttaaatgg     4440
aactatgact caaaacctca aacttcgatt taccacatgn natcataata cagcaatggc     4500
aataatggaa ctatgacata tgtttatcac aacattcgtg acaatgaatc ataatacagc     4560
aatggcttaa aaggaactat gacgacatgg atattcttcc gacagattta aaatcataat     4620
acagcaacgg cttaaaagga actatgacac ctctggcttt gtttctggct taacttctat     4680
cataatacag taatggctta aatggaacta tgaccgaggt tactagctta ggtgcattct     4740
acttatcata aaacagcaat ggctttagtg gaactatgac tctagactat tatctttatg     4800
tttcacgcaa atcataaaac agcaatggca ttaatggaac tatgaccctt gatgtcaacc     4860
tgttttctac gctcgatcat aaaacagcaa cggcttaaat ggaactatga caacacagaa     4920
gtttataaaa agaaataata atcataaaac agcaatggct taaatggaac tatgaccttc     4980
aggtgcatgt gcatctttta ttaggtatca taatacagca atggcaataa tggaactatg     5040
acgcaaatga tgattacacc gttgaaaaaa tatcataaaa cagcaatggc tttaatggaa     5100
ctatgactgc atgaggaatt gttgttctgt cttctttatc ataaaacagc aatggtaaaa     5160
atggaactat gactaatgca gacttaagtc agaataagcg tagatcataa tacagctgaa     5220
aaatacaata ataagttcat tatagcgcta tgctactttt tccccgggtt tatttttatc     5280
atttgaattt gaaatatatc tctgtcctct attcccagga cacgcatttc ttcttttaaa     5340
gatcgccagg gttcaatctt aatagattta gtagttttat ctagcagagt atactcgtgt     5400
acgtaatatg ttttttcgtt tttgctcatt gtaactcctc tgttcttctt aaaataattg     5460
aaaatctgta ggtatataaa aattacatat taagtgctgg tttttaatta gtgtttgttg     5520
gagattgctt atagtaattg taatatcttt ttaaggataa gtgagactta aagccgattt     5580
gctgcataat ttgttcaggg ttatttttct gtttaatttt acttaaaata                5630

<210>  3
<211>  6416
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 3 (Bacillus species)

<400>  3
ccttaaaaag atacgatgcg tactacgcag acactaacca gaacaagggt taaaaaacta       60
cacttgttat ataaatttta tatacctaca ggtttttgag gtaagttgga gttgttaaga      120
tgaaaaaaaa caaggagtca tattttatac acgaatatac cttgcgagac aagactacta      180
aatcaataaa aattgaatca tggcgttcat taaaggaaga aatgatagcc ctgggcataa      240
aagacagtga catctttcaa attcaaatgc taaaaataga ttcaaaaaaa gagtaacata      300
gcgctatgcc atgttactct tttttatttt aataatataa agtcgttttt ctacgctcaa      360
aagcaactag ttccgcaaac aaaaatataa attactattt caaaaaacaa gagaacttaa      420
ggattaaact gacgagaaat cctctttttt ataagtgaaa tccttatcta aggctatatt      480
agcaaggttt ttgagacatc catcatagca tagcaatttt tcttatggaa ctatagccgt      540
ttttacagca tcttcatctt tttctaaatc atagcattgc gatttttttt tggaactatt      600
gccccttgac cttttctttg ccttgatctt tatcatagca tagcaatttt tcttatggat      660
ctatagcata gttgtggatg tggaggaaat ggctactatc ataacattgc aatatttctt      720
ttggaactat agccatatcg ccagtatcaa cattcacttc tgatcataac atagtaatat      780
ttcttatgga tctatagcct cgttattctt gattaaatat atacgaagat catagcatag      840
cgattttcct tatggaacta tagcaactgg cggggctact agaaaggaga tgttgatcat      900
agcatagcga tttcccttat ggaattatag caccgttact aattgttcaa cacttaaatt      960
aaccatagca ttgcaatatt tcttatggaa ctatagccca atttcgcatg gatgtacttt     1020
ttagtatcat agcgtagcga tgtttcctat ggaactatag caaggttact gatgctaagg     1080
atgtagtgac tatcatagca atttttctta tgaaactata gcagcctgtg tgctagacag     1140
tacctataat acaccatatc atagccttat ttcttatgga actatagcag aatccccgtg     1200
ttagcctatc caggctatat catagcattg cgatgtttct tagagaacta taatattttt     1260
ctatttattt gtggtgaaaa aaattatagc atagtgatat tctctacgga atgatagcat     1320
taatattaac aagttaagat atgttcctct taattaattc atatcactat tattcccaat     1380
ctcattattt ttataattat tcgtttatct aggtataaag tttattttac gggtcaataa     1440
tgaaaccata aggatcatat catagcgatg tttcttaagt tactatagta agggcaatga     1500
cccgtggcgt ttggggatcg ccttatcctg gtatggatat tctccccatg tgaaaagcac     1560
ctaagcatag cgctatggtg cttttatttt gtaaaacatg aaggaggtta tgaaattgaa     1620
atatgtatta gggttggata ttggaatcgc atcatgtggt tgggcagtaa taaatcaaga     1680
aaaacataga attgaagatt taggggttcg tatttttgat aaagctgaga atcccaaaga     1740
tggaaaatct ttagctacac ctagacgtga cgcacgctct accagaagaa ccctacgccg     1800
taaaaaacat agaatgcaac ggataaagat acttttagta aagcacggct tactatccaa     1860
gaccgaaatc gaccatctat atgaaagtgc tactgagatc gatgtttggt acttacgttt     1920
aaatgctcta gagcgcagat taaatccaaa agagtttgct agagttctta ttcaccttgc     1980
taaaagaaga ggatttaaat ctaatagaaa agaaacaact ctctcggaaa acggacaaat     2040
cttagaaaat atttcagaga acctgcagat tatggagcaa aaaaattata gaactgttgg     2100
agaaatgatt ctaaaagata aaagatttga aaatcataaa agaaacaaag atggtactta     2160
tatcgggact gttactcggc aacaacttca agaagaaata caaatgatat tcaatgcaca     2220
acgtttgtac aaaaacaatc atgcaacaga gaaatttgaa agtagctact tagaaatctg     2280
ggcatctcaa cgtccctatg cttctaaaga tcaaattgaa aaaatgattg gttactgtac     2340
cttagagcca aaagaaaaaa gagtgcctaa agcttcttgg tcatttcaat attttgtagc     2400
gctacaaacc ataaacaacc tccgactgat cagtaaagac aggatagaag aactctcttt     2460
tgaagaaaag aaacgaatta tgaatctagc actcgaaaaa tcaattgtta aatacattga     2520
tatccgaaaa ttactatctg ttcctaatga atttcaattt aatagccttt catattcagc     2580
tgatatagta gatacaacgg tggaaaataa aaaatgtata gaactcaaag aatatcactc     2640
tattaacaag gtatataaac aaatttacgg acagaacgct ctaaatttat tacctaaaga     2700
ttacgataca attgcatacg gacttactat ctttaaagat gataaagata tcctagaata     2760
tttacaaaat aaatacgtaa atgcaaaagg aaaacctata agtaatttag ctaacaagac     2820
ctacgatgat acatttattc aggtattatt gactctgaat ttctcaaaaa tgggacattt     2880
atcatttaaa gctttaaaaa atattattcc ttttttagaa gaaggtctat cctacgataa     2940
agcatgtgag aaggcaggat acaactttaa gggagcatcc tacacaaaaa aaacaaagta     3000
cctacctgtt atccctcaga atacaaatcc tgttgtacat cgtgctcttt cacaaacaag     3060
aaaagttata aatgccatta taaaaaaata tggttctcca aacgcaatcc atattgaaac     3120
tgcaagagaa ttatcgaaaa cattccaaga aagaaaagaa atagatagta tgtaccagga     3180
taactctaaa aagaatgaac acgccatttg taagttaaaa gaattgggga atattaaacc     3240
ctcaggaata aatattgtga aatttaagct ttggaacgag caagatggta gatgtatgta     3300
ttctggaaaa tatattgaac cacatcgctt atttgaagaa ggttatacgg aagtagatca     3360
tatactccct tacagccgta gcttagatga cagctataac aataaagtat taacgctagg     3420
aacagaaaat cagcgtaaag gaaacaaaac tccttatgaa tacatgagga ataattcaat     3480
ttgggatgaa tttgaaacaa gagtacagtc aaataaaaaa atcaacaaaa agaaacaaca     3540
aaaattactt ttacaaaact tttcacatgc gagagaacaa gaatttattg aacgcaatct     3600
caatgatacc cgttatgcca caatatatct atcatccctt attcaacaac acctcatatt     3660
ctctgaaagc tctcgtgaga aaaaagttca tacagttagt ggaattataa catctcattt     3720
gcgtagtaga tggggattta acaaagatcg gaaagagggg catatccatc atgctttaga     3780
tgcggtaatc gttgctgtca catccgatca catgattcaa agagtaacaa aatattataa     3840
gttaaaagag ttaaatagaa atattcaagc caaacggatg cagtttcctg aaccttggga     3900
aggatttcgt ttagagttag aagcaagagt ttctccaaat acccagcaat atttaaaggg     3960
tattcgtttt aaaaattacg ccgatgtcga tctatccgaa atcaaaccta tctttgtttc     4020
aagaatgcct aagcgctcta ttactggtga attacatcaa gaaacaatcc ggaaattcct     4080
tggttataac gaaaagggga aagtgctaac cgcgacaaaa acaaaattag aagatattcc     4140
ttttgatgct aatggtgatt ttcccatgtt tggaaaagaa actgatttat atacgtataa     4200
tgccataaaa gaacgttatt taagtcataa aaaagataaa cgcaaatcat tccaagagcc     4260
tttatacaaa cccacaaaat caggaggaat tggaccactt ataaaatcta ttaaaataat     4320
ggatacaaga accattgtta atcctgttaa tcaaggtaaa ggtgtcgtgt ataatagtaa     4380
aattgctcgt actgatgtat tcaaaaaggg tgagaagtac tatttaattc ccatttacac     4440
aattgatctt atgaaaaata tcttacctca aaaagcaatt acagcaggaa aaggatatga     4500
ggattggaca actattgatc ctagctttac ttttttgttt agtctttttc ccaatgatct     4560
aatccaaatt gtcccctcaa aaaacaaaac aattaaagct agaacaactg tatcgaaaaa     4620
agaggtatta ctaccctcac tcacaggata ttttaaaggt gttcatagtg gaactgctgg     4680
gattactgtt gaaacacatg atggcagtat tatagcaaat gtaggctcca agcagttact     4740
atcatttgag aaataccagg tagatgtact tggacattac acaaaaatta agaaggaaaa     4800
acgtattgga atggcaatat agaatggtaa caaaaaacgc agcttgctaa tatagaattt     4860
tgaataggga aacatatgca aacaaagaag atattatctc tgcttaactt actttatttt     4920
aaaaagaaaa aaatcgcatt ctaaacaaat gaaacctctc ctttttcaaa ttaaaaaacc     4980
ttgtctaatc ctctagtgac aaggtttttc agcatctacc agaaaataac gatttttctt     5040
atggaactat agcggtggtg attatggcca aaggtaaggt acaaccatag catagcgatt     5100
tttctcatgg aactttagct tggaaaactc catactggca aaaacattac catagcatgg     5160
cgatttttct tatggaacta tagcaggaga ctcggttttc tgactaggag tcagaccata     5220
gcatagcgat gtttcttacg gaactatagc ctcggtgtat atcgaaggac aaaggaatag     5280
accataccat agcgatgttt cttatggaac tatagcaaca cgttttgaaa cacaatcttg     5340
atcatatcat agcaacgttt tttatggagc tacagctggc ttttgtggtc tgtggtctct     5400
ttttcaccat agcatagcga tgtttcttat gaaactatag cgttaaatta ccatttggtc     5460
caatggattt aatcatacca tagcgacatt tcttatggaa ctatagccgg tttcaactcc     5520
ttttaaggca tttctcaacc atagcatagc gatgtttctt atggaactat agcgttttgg     5580
atcaggtgca tcaggaagag cataccatag catagcgata tttcttatgg aactatagcc     5640
tcttaacgaa tccagtagca gcagaacata ccatagcata gcgatatttc tcatggaact     5700
atagcccaat ccatcatgca tgggtggtag ttgaaccata gcatagcgat gtttcttatg     5760
gaactatagc gttaatacat actcttaatc cttataattc accatagcat agcgatgctt     5820
cttatggaac tacagctcgc cgcccataaa caagcttatt tttctatcat tttatattaa     5880
tattatatat tacaatgcct tatatatatt tttaacaaaa atatatatcc caaacctaaa     5940
agactaaata taacttataa atttacttat caaatagcct ccagcaagga aattgtacac     6000
ttactcttac tttaaaatca gtaagtttta ttagtacatt tacataaata atcccttcgc     6060
ctatacacaa aagaattatg ttataataac tactgaacat atgaatagga taacaactac     6120
ctgctgttgg caagtagaaa tttatctaat aaaaagatca cctgtttcca agacaagtga     6180
tctttttgta tacatttcct gtactttttt gagattccat ttgccaatac tacccataaa     6240
actttataaa aagtgttctc ctgccactaa aaacatgatt aaccaaaaac acactatcat     6300
aagacataca gtcctacatt tccctacaaa ggactcaact ttttctacta tatatttcat     6360
gttagttcat ttccttttcc tcttaattag catattcaac ccaacatttt tcttta         6416

<210>  4
<211>  5667
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 4 (Bacillus species)

<400>  4
taatgaatta aatgaataca gaggtttaat gatgaaaaaa aatgaggaat catattatat       60
caatcaatac actttacgag atggtactac taaatctatt aagattgaat cttggcgctc      120
actaaaagat gaaatgatag ccctgagcat aaaagacagt gacatctttc aaattcaaat      180
gctaaaaata gattcaaaaa aagagtaaca tagcgctatg ccatgttact cttttttatt      240
ttaataatat aaagtcgttt ttctacgctc aaaagcaact agctccgcaa acaaaaatat      300
aaattactat ttcaaaaaac aagagaactt aaggattaaa ctgacgagaa atcctctttt      360
ttataagtga aatccttatc taaggctata ttagcaaggt ttttgagaca tccatcatag      420
catagcaata tttcttatgg aactatagca tagttgtgga tgtggaggaa atggctacta      480
tcatagcata gcaatatttc ttttggaact atagccatat cgccagtatc aacattcgct      540
tctgatcata acatagtaat atttcttatg gatctatagc ctcgttattc ttgattaaat      600
atatacgaag atcatatcat agcgattttc cttatggaat tatagcaccg ttactaattg      660
ttcaacgctt aaattaacca tagcattgca atatttctta tggatctata gcccaatttc      720
gcatggatgt actttttagt atcatagcgt agcgatgttt cctatggaac tatagcaagg      780
ttactgatgc taaggatgta gtgactatca tagcaatttt tcttatgaaa ctatagcagc      840
ctgtgtgcta gacagtacct ataatacacc atatcatagc cttatttctt atggaactat      900
agcagaatcc ctgtgttagc ctatccgggc tatatcatag cattgcgatg tttcttaggg      960
aactatagca tttccgctaa cgttttgttg tctctccata tcatatcata gcgatgtttc     1020
ttagagaact atagtatttt tctgtttatt tgtggtgaaa aaaattatag catagggata     1080
ttctcaacgg aatgatagca ttaatattaa caagttaaga aatgttcctt ttaattaatt     1140
catatcacta ttatttccaa tctctttatt tttataatta tacgtgtatc taagtataaa     1200
gtttattttc tgggtcaata atgaaatcat aaggatcata tcatagcgat gtttcttaag     1260
ttactatagt aagggcaatg acccgtggcg tttggagatc gcctcatcca ttacggatat     1320
tctccccatg tgaaaagcac ctaagcataa ggctaaggtg cttttatttt gaaaaacgtg     1380
aaggaggtcg tgtaattgca atatgtatta ggattggata ttggaatcgc atcttgtggt     1440
tgggctgtaa tcaatcaaga aaaagagaga attgaagatt taggggttcg tatttttgat     1500
aaagctgaaa atcccaaaga cggaaaatct ttagctgcac ctaggcgtga cgcacgctct     1560
actaggagaa ccctacgccg taaaaaacat agaatgctac ggataaagat acttttagta     1620
aaacaaggct tactatctaa gaacgaactt aaccatctat atgaaagtac tactgaagtc     1680
gatgtttgga acttacgttt agatgctcta gaacgcaaat tgaatccaaa agagtttacc     1740
agagttctta ttcatcttgc taaaagaaga ggatttaaat ctaatagaaa agaaaccact     1800
ctctcagaaa acggacaaat cttagaaagc atttcagaga atcaacagat tatggagcaa     1860
caaaattata gaactgttgg agaaatgatt ctaaaagata aaaaatttga aaaccataaa     1920
agaaacaaag atggtactta tatcgggacc gttacccgtc aacaacttca agaagaaata     1980
caaatgatat tcactgcaca acgtttgtac aaaaacgatt atgcaacaga ggaatttgaa     2040
attagctact tagaaatctg ggcatctcaa cgtccctatg cttctaaaga tcaaattgaa     2100
aaaatgattg gttactgtac cttagagcca aaagaaaaaa gagtgcctaa agcttcttgg     2160
tcatttcaat attttgtagc gctacaaacc ataaacaacc tccgactgat cagtaaagac     2220
aggatagaag aactctcttt caaagaaaag aaacaaatta tgaatctagc acttgaaaaa     2280
tcaattgtta aatacattga tatccgaaaa ttattatcca ttcctaatga atttcagttt     2340
aatagcctat catattcagc tgatacagta gatactacgt tggagaataa aagatgtata     2400
gaactcaagg aatattactc tattaacaag gtatataaac aaatttatga gaagaacgcc     2460
ctaaatttat tacctataga ttacgataca attgcatacg gactaactat ctttaaagat     2520
gataaagata tccttgaata tttacaaaat aaatatgtaa atgcaaaagg aaaacctata     2580
aataatttag ctaaaaagac ctacgattac acatttattc aagcattact gactctgaat     2640
ttcacgaaaa tgggacattt atcatttaaa gctttaaaaa atattattcc tttcttagaa     2700
gaagggctat catacgataa agcatgtgag aaggcaggat acaactttaa aggaacatcc     2760
tacacagaaa aaacaaagta cctacctgtt atccctcaaa atacaaatcc tgttgtacat     2820
cgtgctcttt cacaaacaag aaaagttata aatgccatta taaaaaaata tggttctcca     2880
aacgcaatcc atattgaaac tgcaagagaa ttatcgaaaa cattccaaga aagaaaagaa     2940
atagatagta tgtaccagga taactctaaa aagaatgaac acgccattca taagttaaaa     3000
gaattgggga acattaaccc ctcaggaata aatattgtga aatttaagct ttggaatgag     3060
caagatggta gatgtatgta ttctggaaaa tatatcgaac cacatcggtt atttgaagaa     3120
ggttatacgg aagtagatca catactcccc tatagccgta gcttagatga tagctataac     3180
aacaaaacat taacactagg aacagaaaat cagcgtaaag gaaacaaaac tccttatgaa     3240
tacatgggga atacttcaat ttggaatgac tttgaaacaa gggtacattc aaataaaaaa     3300
atcaacaaaa agaaacaaca aaaattactt ttacaacact tttcatatgc gagagaacaa     3360
gaatttattg aacgcaatct gaatgatacc cgttatgcca caatatatct atcatccctt     3420
attcaacaac acctcatatt ctctgaaagc tctcgtaaga aaaaagttca tacagttagt     3480
ggaattataa catctcattt acgtagtaga tggggattta acaaagatcg gaaagaggga     3540
catattcatc atgctttaga tgcggtaatc gtcgctgtca catccgatca catgattcaa     3600
agagtaacaa aatattataa gttaaaagag ttaaatagaa accttcaagc caaacggatg     3660
ccgtttcctg aaccttggga aggatttcgt ttagagttag aagcaaggat ttctccaaat     3720
acccagcaat atttaaaggg atttcgtttt aaaaattacg ccgatgtcaa cctatccgaa     3780
atcaaaccta tctttgtttc aagaatgcct aagcgctcta ttactggtga attacatcaa     3840
gaaacgattc ggaaattcat tggttataac gaaaaaggga aagtattaac cgcaataaaa     3900
acaaaattag aagatatccc ttttgatgcc aatggtgatt ttcccatgta tgggaaagaa     3960
actgatttat atacgtataa tgccataaaa gaacgttttt taagtcataa aaaagataaa     4020
cgcaaatcat tccaagaacc tttatacaaa cccacaaaat caggaggaat tggaccactt     4080
ataaaatcta ttaaaataat tgatacaaga accattgtta atcctgttaa tcaaggtaaa     4140
ggtgtcgtgt ataatagtaa aattgctcgt actgatgtat tcaaaaagga tgagaagtac     4200
tatttaattc ccatttacac aattgatctt atgaaaaata tcttacctca aaaagcaatt     4260
acagcaggaa aaggatatga ggattggaca accattgatc ctagctttac ttttttattt     4320
agtctttttc ccaatgatct aattcaaatt gtcccctcaa aaaataaaac aataaaagct     4380
agaacaactg tatcgaaaaa agaggtatta ctaccctcac tcacaggata ttttaaaggt     4440
gttcatagtg gaactgcggg gattactgtt gaaacacacg atggcagtgt tatagcaaat     4500
gtaggctcaa agcaattact attaattgag aaatatcaag tagatatact tggacattat     4560
acaaaaataa aggaggaaaa acgtattggg atggcgatat agaatggtaa caaaaagagc     4620
gcagcttgct aatatggaat tttcaatagg gaaacatacg caaacaaaga agatactagc     4680
tctgctcaac ttactttatt ttaaaaagaa aaaaatcgca ttctaaacaa atgaaatccc     4740
tcctttttca aattaaaaaa ccttgtctaa tcctctagtg acaaggtttt ttcgacatct     4800
accctatcat agcgttggtt cttttggaac tatagctata ctaaggaata tcaagaacat     4860
ttagcgatca tatcatagcg ttggttcttt tcgaactata gcgcgttcaa ttgctgtttg     4920
acaataccta aaaccacatt atagcggttt ttcttatgga actatagctc tctgttgcga     4980
ttccattaac gttcttagat catagcatag cgacttttct tttggaacca tagcctctca     5040
tcaatataac gttgctgttt catccatcat atcatagtgt tggttccttt cgaactatag     5100
cgcactccat gacgggacac catcaacgta aaccatatca tagcgatggt tcttatggga     5160
ctatagccac aacacactta tcaatattaa ttcctatacc atatcatagc gatggttctt     5220
ttcgaactat agccacgttt tgtgtctggt aatatcgtac cgtaccatat catagtgata     5280
gttcttagcg taatttccgt aaaccatatc ttagcgttgg ttctttcggg actatagacg     5340
tttaaggatt gacacaaaat attcctaaaa acacattacc ttcaaaataa aattggatta     5400
ttttatatat agttttaacc aataaaatat gttccaaaca tagctactct tacatatcat     5460
tgtttttagc atttccttta ctaacctgaa aaatattgta attaaccatt acaaatgcct     5520
tgtatagcgc tatgacaatt taatacatgc aaatgaatga caagtcacac ttcccatatt     5580
cacatataca taacgaaatg tttcaaatca agactaatat agtgttacac aattgttgtt     5640
cttcaaaaaa tattttacac atttaca                                         5667

<210>  5
<211>  6120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 5  (unknown origin)

<400>  5
gtaaagcaag taggatttaa aactcacgta tccttaaaaa gatatgatac gtactatgca       60
gacactaacc agaacaaggg ttaaaaaact acacttgtta tataaatttt atatacctac      120
aggtttttga ggtaagttgg agttgttaag atgaagaaaa acaaggattc atatttcata      180
cacgaatata ccttgcgaga caagactact aaatcaataa aaattgaatc gtggcgttca      240
ttgaaggaag aaatgatagc cctgggcata aaagacagtg acatctttca aattcaaatg      300
ctaaaaatag attcaaaaaa agagtaacat tagcgctatg ccatgttact cttttttatt      360
ttaataatat aaagtcgttt ttctacgctc aaaagcaact agttccgcaa acaaaaatat      420
aaattactat ttcaaaaaac aagagaactt aaggattaaa ctgacgagaa atcctctttt      480
ttataagtga aatccttatc taaggctata ttagcaaggt ttttgagaca tccatcatag      540
catagcaatt tttcttatgg aactatagct gtttttacag catcttcatc tttttctaaa      600
tcatagcatt gcgatttttt ttttggatct atagcatagt tgtggatgtg gaggaaatgg      660
ctactatcat agcattgcaa tatttctttt ggaactatag ccatatcgcc agtatcaaca      720
ttcgcttctg accataacat agtaatattt cttatggatc tatagcctcg ttattcttga      780
ttaaatatat acgaagatca tagcatagcg attttcctta tggaactata gcaactggcg      840
gggctactag aaaggagatg ttgatcatag catagcgaat gctcctatgg aactatagcc      900
tactaaacac aaaccctatt ccatcataga tcatatcata gcgatttttc ttagggaact      960
atagcccaaa ttccaaaaca aaataaaata gttgcatcat atcatagcga tgtttccttt     1020
ggaactatag cgacttggga tgattcgtct tatccttgga atcatagcat agcaatattt     1080
cttatggaac tatatcctct tgcgcaaggt ctttaaattc atcatcatag cataacgatt     1140
tttcttttgg aactatagtc tgttatgtgt ccctctaact ctaaaatcca tcatagcata     1200
gcgatattct ctacggaatg atagcattaa tattaacaag ttaagatatg tgcctcttaa     1260
ttaattcata tcactattat tcccaatctc attattttta taattattcg tttatctagg     1320
tataaagttt attttacggg tcaataatga aaccataagg atcatatcat agcgatgttt     1380
cttaagttac tatagtaagg gcaatgaccc gtggcgtttg gggatcgcct tatcctggta     1440
tggatattct ccccatgtga aaagcaccta agcatagcgc tatggtgctt ttattttgta     1500
aaacatgaag gaggttatga aattgaaata tgtattaggg ttggatattg gaattgcatc     1560
atgtggttgg gcagtaataa atcaagaaaa acatagaatt gaagatttag gggttcgtat     1620
ttttgataaa gctgagaatc ccaaagatgg aaaatcttta gctacaccta gacgtgacgc     1680
acgttctacc agaagaaccc tacgccgtaa aaaacataga atgcaacgga taaagatact     1740
tttagtaaag cacggcttac tatccaagac cgaaatcgac catctatatg aaagtgctac     1800
tgagatcgat gtttggtact tacgtttaaa tgctctagag cgcagattaa atccaaaaga     1860
gtttgctaga gttcttattc accttgctaa aagaagagga tttaaatcta atagaaaaga     1920
aacaactctc tcggaaaacg gaaaaatctt agaaaatatt tcagagaacc tgcagattat     1980
ggagcaaaaa aattatagaa ctgttggaga aatgattcta aaagataaaa aatttgaaaa     2040
tcataaaaga aacaaagatg gtacttatat cgggactgtt actcggcaac aacttcaaga     2100
agaaatacaa atgatattca atgcacaacg tttgtacaaa aacaatcatg caacagagaa     2160
atttgaaagt agctacttag aaatctgggc atctcaacgt ccctatgctt ctaaagatca     2220
aattgaaaaa atgattggtt actgtacctt agagccaaaa gaaaaaagag tgcctaaagc     2280
ttcttggtca tttcaatatt ttgtagcgct acaaaccata aacaacctcc gactgatcag     2340
taaagacagg atagaagaac tctcttttga agaaaagaaa cgaattatga atctagcact     2400
cgaaaaatca attgttaaat acattgatat ccgaaaatta ctatctgttc ctaatgaatt     2460
tcaatttaat agcctttcat attcagctga tatagtagat acaacggtgg aaaataaaaa     2520
atgtatagaa ctcaaagaat atcactctat taacaaggta tataaacaaa tttacgaaca     2580
gaacgctcta aatttattac ctaaagatta cgatacaatt gcatacggac ttactatctt     2640
taaagatgat aaagatatcc tagaatattt acaaaataaa tacgtaaatg caaaaggaaa     2700
acctataagt aattttgcta acaagaccta cgatgataca tttattcagg tattattgac     2760
tctgaatttc tcaaaaatgg gacatttatc atttaaagct ttaaaaaata ttattccttt     2820
tttagaagaa ggtctatcct acgataaagc atgtgagaag gcaggataca actttaaggg     2880
aacatcctac acaaaaaaaa caaagtacct acctgttatc cctcagaata caaatcctgt     2940
tgtacatcgt gctctttcac aaacaagaaa agttataaat gccattataa aaaaatatgg     3000
ttctccaaac gcaatccata ttgaaactgc aagagaatta tcgaaaacat ttcaagaaag     3060
aaaagaaata gatagtatgt accaggataa ctctaaaaag aatgaacacg ccattcataa     3120
gttaaaagaa ttggggaaca ttaacccctc aggaataaat attgtgaaat ttaagctttg     3180
gaatgagcaa gatagtagat gtatgtattc tggaaaatat atcgaaccac atcgattatt     3240
tgaagaaggt tatacggaag tagatcatat actcccctat agccggagct tagatgacag     3300
ctataacaat aaagtgttaa cgctagggac agaaaatcag ggtaaaggaa acagaactcc     3360
ttatgaatac atggggaata cttcaatttg ggatgaattt gaaacaagag tacagtcaaa     3420
taaaaaaatc aacaaaaaga aacaacaaaa attactttta caaaactttt cacatgcgag     3480
agaacaagaa tttattgaac gcaatctcaa tgatacccgt tatgccacaa tatatatatc     3540
atcccttatt caacaacacc tcatattctc tgaaagctct cgtgagaaaa aagttcatac     3600
agttagtgga attataacat ctcatttgcg tagtagatgg ggatttaaca aagatcggaa     3660
agaggggcat atccatcatg ctttagatgc ggtaatcgtt gctgtcacat ccgatcacat     3720
gattcaaaga gtaacaaaat attataagtt aaaagaatta aatagaaacc gtcaagccaa     3780
acggatgcag tttcctgaac cttgggaagg atttcgttta gagttagaag caaggatttc     3840
tccaaatacc cagcaatact taaagggaat tcgtttaaaa aattacgccg atgtcaatct     3900
atctgaaatc aaacctatct ttgtttcaag aatgcctaag cgctctatta ctggtgaatt     3960
acatcaagaa acaatccgga aattccttgg ttataacgaa aaagggaaag tgctaaccgc     4020
aataaaaaca aaattagaag atattccttt tgatgctaat ggtgattttc ccatgtatgg     4080
aaaagaaact gatttatata cgtataatgc cataaaagaa cgttatttaa gtcataaaaa     4140
agataaacgc aaatcattcc aagaaccttt atacaaaccc acaaaatcag gaggaattgg     4200
accacttata aaatctatta aaataatgga tacaagaacc attgttaatc ctgttaatca     4260
aggtaaaggt gtcgtgtata atagtaaaat tgctcgcact gatgtattca aaaaggctga     4320
aaagtactat ttaattccca tttacacaat tgatcttatg aaaaatatct tacctcaaaa     4380
agcaattaca gcaggaaaag gatatgagga ttggacaacc attgatccta gctttacttt     4440
tttgtttagt ctttttccca atgatctaat ccaaattgtc ccctcaaaaa ataaaataat     4500
taaagctaga acaactgtat cgaaaaaaga ggtattacta ccctcactca caggatattt     4560
taaaggtgtt catagtggaa ctgctgggat tactgttgaa acacacgatg gcagtattat     4620
agcaaatgta ggctccaagc agttactatc atttgagaaa taccaggtag atgtacttgg     4680
acattacaca aaaattaaga aggaaaaacg tattggaatg gcaatataga atggtaacaa     4740
aaaacgcagc ttgctaatat agaattttga atagggaaac atatgcaaac aaagaagata     4800
ttatctctgc ttaacttact ttattttaaa aagaaaaaaa tcgcattcta aacaaatgaa     4860
acctctcctt tttcaaatta aaaaaccttg tctaatcctc tagtgacaag gtttttcagc     4920
atctaccaga aaataacgat gtttcttatg gaactatagc ggtggtgatt atggccaaag     4980
gtaaggtaca accatagcat agcgattttt ctcatggaac tttagcttgg aaaactccat     5040
actggcaaaa acattaccat agcatggcga tgtttcttat ggaactatag caggagactc     5100
ggttttctga ctaggagtca gaccatagca tagcgatgtt tcttacggaa ctatagcctc     5160
ggtgtatatc gaaggacaaa ggaatagacc ataccatagc gatgcttctt atggaactat     5220
agccggtttc aactcctttt aaggcatttc tcaaccatag catagcgatg tttcttatgg     5280
aactatagcg ttttggatca ggtgcatcag gaagagcata ccatagcata gcgatatttc     5340
ttatggaact atagcctctt aacgaatcca gtagcagcag aacataccat agcatagcga     5400
tatttctcat ggaactatag cccaatccat catgcatggg tggtagttga accatagcat     5460
agcgatgttt cttatggaac tatagcgtta atacatactc ttaatcctta taattcacca     5520
tagcatagcg atgcttctta tggaactaca gctcgccgcc cataaacaag cttatttttc     5580
tatcatttta tattaatatt atatattaca atgccttata tatattttta acaaaaatat     5640
atatcccaaa cctaaaagac taaacataac ttataaattt acttatcaaa tagcctccag     5700
caaggaaatt gtacacttac tcttacttta aaatcagtaa gttttattag tacatttaca     5760
taaaaaatcc cttcgcctat acacaaaaga tttatgttat aataactact gaacatatga     5820
ataggataac aactacctgc tgttggcaag tagaaattta tctaataaaa agatcacctg     5880
tttccaagac aagtgatctt tttgtataca tttcctgtac ttttttgaga ttccatttgc     5940
caatactacc cataaaactt tataaaaagt gttctcctgc cactaaaaac atgattaacc     6000
aaaaacacac tatcataaga catacagtcc tacatttccc tacaaaggac tcaacttttt     6060
ctactatata tttcatgtta gttcatttcc ttttcctctt aattagcata ttcaacccaa     6120

<210>  6
<211>  3213
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 1 (Cas-Locus 1)-Bacillus species

<400>  6
atgagagagt tggattatcg cataggatta gatattggaa cgaattctat tggctggggg       60
atcattgaat tatcttggaa caaagataga gaacaatatg agaaagcaag aattgtcgac      120
aagggtgttc gtatgtttga taaggctgaa atacctaaga ctggtgcttc tcttgctgaa      180
ccgaggcgtt tagcgcgctc atcacgtaga agattaaatc gcaaaagcca gagaaaaaaa      240
gatatacgta atttacttgt tcaacatgaa attattagtc aaagggaatt ggcttcgtta      300
tatcccctgt caaaaagttc aatggatatt tgggatattc gattggaggg attagatcgc      360
ttgttagacc attttgaatg gactcgatta ttaattcatt tagcgcaaag gcgcggtttt      420
aaatcaaatc ggaagtctga attgaaagat gtggagacag gaaaagtatt atcaagtatt      480
caagcaaatg aaaaacgatt atcactgtac cgtacagtgg gagagatgtg gatgaagaat      540
gaagatttta gtaaatatga caaaaggcgt aattctccta atgagtatgt attttcggtt      600
agccgtgcag atttagaaaa agaaattgtg actctatttg aagcgcaaag aaaatttcag      660
tcatcatatg catcggttga tttacaaaaa acatacttac aaatttgggc acaccaactt      720
ccttttgctt ctgggaatgc aattgtaaat aaagtgggat attgttcatt attaaaaggt      780
aaagaaaaga gagttccgaa agcaacatat acttttcaat atttcagtac actagatcaa      840
ataaatcgaa cacgattagg tcctaatttc caaccattta cgaaggaaca gagagacatt      900
attttagata aaatgtttaa tcgaacagat tattataaaa aaaagacaat acccgaagtt      960
acttactatg atattcggaa atggttagca ttagatgaaa caattcaatt taaaggactt     1020
acctatgacc caaatgaaga gctgaaaaaa atagaattga aatcctttat taatttaaag     1080
ccattttatg aaattaaaca ggtagttact aattacgcca agaaaataaa tgaggcattc     1140
tcaacattag actatgatac atttgcatat gctttaacag tttataaaac ggacaaagat     1200
attagatctt atttaaagaa atctaataat ttatcaaaat gttgctacga tgatcaatta     1260
atagaagagc tattaactct ctcctataca aagtttggtc atttatcatt taaagcaatt     1320
aatcatgtac tgccaattat gcaagaggga aggacttatc aggaagcaat acaccaatta     1380
ggatatgata ccactaatct aaaaaaagaa aacagaagta tgttcttgcc ccttattccc     1440
gatgagataa caaatccaat tgttaaaaga gcactaactc aagcacgtaa agttgtaaat     1500
gctattatta gaagatatgg ttccccaaat tctgttcata ttgaactagc ccgtgagctt     1560
cctaaaaatc atgatgagag aacgaaaata atgaaagctc atgatgaaaa ttataagaaa     1620
aataaaggag ccatatcaat tttgattgag aatggaattt taaatccgac aggatatgat     1680
attgtacgtt ataagttatg gaaagagcaa ggagagcgat gtgtttattc gctaaaacag     1740
attcctgcta atacgttttt taatgaattg aaaaaagagc gaagtggccc cccggttcta     1800
gagatagatc acattttacc gtatagtcag agttttattg atagttatca taataaagta     1860
ctagtttatg aggaggagaa tcaaaaaaag ggaaatcgaa ttccatatac ttatttttta     1920
gaagaaaata aggactggga aagcttcgaa agctacgtac gattgaatag ttttttgtct     1980
aaaaagaagc gcggatattt attgaaaaaa gcttacttgc caagagagag taacatgatt     2040
aaggagcgtc atttaaatga tactcgatat gctagtagct atctgaaaaa cttcattgag     2100
aaaaatttga aatttaaaga agttgaaggt agtacaagaa acaaacatgt acagacggtt     2160
aacggtataa ttacagccca tctgcgaaaa agatggggat tagaaaaaga taggaaggaa     2220
acatatttgc atcatgcaat ggacgctatt attgttgctt gtacagacca tcatatggtt     2280
actaaagtaa cggagtacta tcaaataaaa gaaagtaata agtcaataaa gaaaccatac     2340
tttcctttgc catgggtggg ctttagagag gaaattttat cacatttagc aaggcaacca     2400
attgctagaa aaattagtga ggaacttaaa attggatatc aatcatttga ttatatactt     2460
gtatcgcgaa tgccaaaaag atctgtcact ggatcagctc atgaacagac aatcatgaaa     2520
aaaggtggta tcgacaaaaa aggtaaaact attatcataa agcgtgtgta cttaaaggat     2580
attaagtttg atgagaatgg cgattttaaa atggttggaa aagaacaaga tttagcaact     2640
tatgaagcga taaagcaaag atatatagag tatggaaaag aatcgaagaa agcatttgaa     2700
acacctttat acaagcctag taaaaaagga aaaggaaacc tcattaaaaa gatcaaagta     2760
gaagtgcaaa ccaaatcttt tgttcgagaa gttaatggag gcgtagctca aaatggtgat     2820
ttagtaagag tagatttgtt tgaaaaggat aatagatatt atatggtacc tatttatgta     2880
atggatactg ttcattccga actaccaaat aaagctgtaa caagcagtaa aggctatgag     2940
caatggttaa caatagataa cagctttacg ttcaaattca gtttatatcc ttatgattta     3000
gtacgacttg taaaaggtga tgaagatcgt ttcctatatt ttagtaccct tgatattaat     3060
tcggatcgtc ttaatttcaa agatgtaaac acgccatcaa agcaggctga aaatcgttat     3120
agccttaaaa caattgagaa tttagaaaaa tatgaggttg gtgttttagg tgatttaagg     3180
tttgtgagac aagaaatacg taaaaatttt taa                                  3213

<210>  7
<211>  3213
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 2 (Cas-Locus 2)-Bacillus species

<400>  7
atgagagagt tggattatcg cataggatta gatattggaa cgaattctat tggctggggt       60
gttgttgaat tatcttggaa caaagataga gaacaatatg agaaagcaag aattgtcgac      120
aagggtgttc gtatgtttga taaggctgaa atacctaaaa ctggtgcttc tcttgctgaa      180
ccgaggcgta cagcgcgttc atcacgtaga aggttaaatc gcaaaagcca gagaaaaaaa      240
gatatacgta atttacttgt tcaacatgaa attattagtc aaaaggaatt ggcttcgtta      300
tatcccctgt caaaaagttc aatggatatt tgggatattc gattggatgg gttagatcgc      360
ttgttagacc gtcttgaatg gactcgatta ttaattcatt tagcacaaaa gcgcggtttt      420
aaatcaaatc gaaagtctga actgaaagat gtggagacag gaaaagtatt atcaagtatt      480
caagtaaatg aaaaacgatt atcactgtac cgtacagtgg gagagatgtg gatgaagaat      540
gaagatttta gtaaatatga caaaaggcgt aattctccta atgagtatgt attttcggtt      600
agccgtgcaa atttagaaaa agaaattgtg actctatttg aagcgcaaag aaaatttcag      660
tcatcatatg catcagttga tttacaaaaa acatacttac aaatttgggc acatcaactt      720
ccttttgctt ctgggaatgc aattgtaaat aaagtaggat attgttcatt attaaaaggg      780
aaagaaaaga gagttccgaa agcaacatat acttttcaat attttagtac actagatcaa      840
ataaaccgaa cacgattagg acctaatttc caaccattta cgaaggaaca gagagacata      900
atcttagata aaatgtttca acggacagat tattataaaa aaaagacaat acccgaagtt      960
acttactatg atattcggaa atggttagca ctagatgaaa caattcaatt taaaggactt     1020
acctatgacc caaacgaaga gctgaaaaaa atagaaatga aactctttat aaatttaaag     1080
ccattttatg aaattaaaaa ggtagttact aattacgcaa aaaaaacaaa tgaggtattc     1140
tcaacattag actatgatac agttgcatac gctttaacag tttataaaac ggacaaagat     1200
attatatctt atttgaagag atctaataat ttatcaaaac gttgttacga tgatcaatta     1260
atagaagagc tattaactct ttcctataca aagtttggtc atttatcatt taaagccatt     1320
aatcatgtac tgccaattat gcaagaggga aggacttatc aggaagcaat acaccaatta     1380
ggatatgata ccactaatct aaaaaaagaa aacagaagta tgttcttgcc ccttattcca     1440
gatgagataa caaatccaat tgttaaaaga gcactaactc aagcacgtaa agttgtaaat     1500
gctattatta gaagatatgg ttcccccaat tctgttcata ttgaactagc tcgtgagctt     1560
tctaaaactc atgatgagag aacgaaaata atgaaagctc atgatgaaaa ttataagaaa     1620
aataaaggag ccatatcaat tttgattgag aatggaattt taaatccgac aggatatgat     1680
attgtacgtt ataagttatg gaaagagcaa ggagaacgat gtgcttattc gctaaaacag     1740
attcatgcta atacgttttt taatgaattg aaaaaagagc gaagtggtcc cccagttcta     1800
gagatagatc acattttacc gtatagtcag agttttattg atagttatca taataaagta     1860
ctagtttatg gggatgagaa tcaaaaaaag ggaaatcgaa ttccatatac ttatttttta     1920
gaaggaaata aggactggga aagctttgaa agctacgtac gattgaatag tttattttct     1980
aaaaagaagc gcggatattt attgaaaaaa gcttacttgc caagagagag taacatgatt     2040
aaggagcgtc atttaaatga tactcgatat gctagtagct atttgaaaaa cttcattgag     2100
aaaaatttga aatttaaaga agtcgaaggt agtacacgaa aaaaacatgt acagacggtt     2160
aacggtataa ttacagccca tctgcgaaaa agatggggat tagaaaaaga tagacaggaa     2220
acatatttgc atcatgcaat ggacgctatt atcgttgctt gtacagacca tcatatggtc     2280
actaaagtaa cggagtacta tcaaataaaa gaaagtaata agtcaataaa gaaaccatac     2340
tttcctttgc catgggtggc ctttagagag gaaattttat cacatttagc aaggcagcca     2400
attgctagaa aaattagtga ggaacttaaa attggatatc aatcatttga ttatatactt     2460
gtatcgcgaa tgccaaaaag atctgtcact ggagcagctc atgaacagac aatcatgaaa     2520
aaaggtggta tcgataaaaa aggaaagaca attatcataa agcgtgtgta cttaaaggat     2580
attaagtttg atgagaatgg cgattttaaa atggttggaa aagaacagga tttagcaact     2640
tatgaagcga taaagcaaag atatatagag tatggaaaag aatcgaaaaa agcatttgaa     2700
acacctttat acaagcctag taaaaaagga aaagggaacc tcattaaaaa gatcaaagta     2760
gaagtgcaaa ccaaatcttt tgttcgagaa gttaatggag gcgtagctca aaatggtgat     2820
ttagtaagag tagatttgtt tgaaaaagat aatagatatt atatggtacc tatttatgta     2880
atggatactg ttcattccga actaccaaat aaagctgtaa caagcagtaa aggctatgag     2940
aaatggttaa caatagataa cagctttacg ttcaaattca gtttatatcc ttatgattta     3000
gtacgacttg taaaaggtga tgaagatcgt ttcctatatt ttagtaccct tgatattaat     3060
tcggatcgtc ttaatttcaa agatgtaaac aagccatcaa agcaggctga aaatcgttat     3120
agccttaaaa caattgagaa tttagaaaaa tatgaggttg gtgttttagg tgatttaagg     3180
tttgtgagac aagaaatacg taaaaatttt taa                                  3213

<210>  8
<211>  3207
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 3 (Cas-Locus 3)-Bacillus species

<400>  8
ttgaaatatg tattagggtt ggatattgga atcgcatcat gtggttgggc agtaataaat       60
caagaaaaac atagaattga agatttaggg gttcgtattt ttgataaagc tgagaatccc      120
aaagatggaa aatctttagc tacacctaga cgtgacgcac gctctaccag aagaacccta      180
cgccgtaaaa aacatagaat gcaacggata aagatacttt tagtaaagca cggcttacta      240
tccaagaccg aaatcgacca tctatatgaa agtgctactg agatcgatgt ttggtactta      300
cgtttaaatg ctctagagcg cagattaaat ccaaaagagt ttgctagagt tcttattcac      360
cttgctaaaa gaagaggatt taaatctaat agaaaagaaa caactctctc ggaaaacgga      420
caaatcttag aaaatatttc agagaacctg cagattatgg agcaaaaaaa ttatagaact      480
gttggagaaa tgattctaaa agataaaaga tttgaaaatc ataaaagaaa caaagatggt      540
acttatatcg ggactgttac tcggcaacaa cttcaagaag aaatacaaat gatattcaat      600
gcacaacgtt tgtacaaaaa caatcatgca acagagaaat ttgaaagtag ctacttagaa      660
atctgggcat ctcaacgtcc ctatgcttct aaagatcaaa ttgaaaaaat gattggttac      720
tgtaccttag agccaaaaga aaaaagagtg cctaaagctt cttggtcatt tcaatatttt      780
gtagcgctac aaaccataaa caacctccga ctgatcagta aagacaggat agaagaactc      840
tcttttgaag aaaagaaacg aattatgaat ctagcactcg aaaaatcaat tgttaaatac      900
attgatatcc gaaaattact atctgttcct aatgaatttc aatttaatag cctttcatat      960
tcagctgata tagtagatac aacggtggaa aataaaaaat gtatagaact caaagaatat     1020
cactctatta acaaggtata taaacaaatt tacggacaga acgctctaaa tttattacct     1080
aaagattacg atacaattgc atacggactt actatcttta aagatgataa agatatccta     1140
gaatatttac aaaataaata cgtaaatgca aaaggaaaac ctataagtaa tttagctaac     1200
aagacctacg atgatacatt tattcaggta ttattgactc tgaatttctc aaaaatggga     1260
catttatcat ttaaagcttt aaaaaatatt attccttttt tagaagaagg tctatcctac     1320
gataaagcat gtgagaaggc aggatacaac tttaagggag catcctacac aaaaaaaaca     1380
aagtacctac ctgttatccc tcagaataca aatcctgttg tacatcgtgc tctttcacaa     1440
acaagaaaag ttataaatgc cattataaaa aaatatggtt ctccaaacgc aatccatatt     1500
gaaactgcaa gagaattatc gaaaacattc caagaaagaa aagaaataga tagtatgtac     1560
caggataact ctaaaaagaa tgaacacgcc atttgtaagt taaaagaatt ggggaatatt     1620
aaaccctcag gaataaatat tgtgaaattt aagctttgga acgagcaaga tggtagatgt     1680
atgtattctg gaaaatatat tgaaccacat cgcttatttg aagaaggtta tacggaagta     1740
gatcatatac tcccttacag ccgtagctta gatgacagct ataacaataa agtattaacg     1800
ctaggaacag aaaatcagcg taaaggaaac aaaactcctt atgaatacat gaggaataat     1860
tcaatttggg atgaatttga aacaagagta cagtcaaata aaaaaatcaa caaaaagaaa     1920
caacaaaaat tacttttaca aaacttttca catgcgagag aacaagaatt tattgaacgc     1980
aatctcaatg atacccgtta tgccacaata tatctatcat cccttattca acaacacctc     2040
atattctctg aaagctctcg tgagaaaaaa gttcatacag ttagtggaat tataacatct     2100
catttgcgta gtagatgggg atttaacaaa gatcggaaag aggggcatat ccatcatgct     2160
ttagatgcgg taatcgttgc tgtcacatcc gatcacatga ttcaaagagt aacaaaatat     2220
tataagttaa aagagttaaa tagaaatatt caagccaaac ggatgcagtt tcctgaacct     2280
tgggaaggat ttcgtttaga gttagaagca agagtttctc caaataccca gcaatattta     2340
aagggtattc gttttaaaaa ttacgccgat gtcgatctat ccgaaatcaa acctatcttt     2400
gtttcaagaa tgcctaagcg ctctattact ggtgaattac atcaagaaac aatccggaaa     2460
ttccttggtt ataacgaaaa ggggaaagtg ctaaccgcga caaaaacaaa attagaagat     2520
attccttttg atgctaatgg tgattttccc atgtttggaa aagaaactga tttatatacg     2580
tataatgcca taaaagaacg ttatttaagt cataaaaaag ataaacgcaa atcattccaa     2640
gagcctttat acaaacccac aaaatcagga ggaattggac cacttataaa atctattaaa     2700
ataatggata caagaaccat tgttaatcct gttaatcaag gtaaaggtgt cgtgtataat     2760
agtaaaattg ctcgtactga tgtattcaaa aagggtgaga agtactattt aattcccatt     2820
tacacaattg atcttatgaa aaatatctta cctcaaaaag caattacagc aggaaaagga     2880
tatgaggatt ggacaactat tgatcctagc tttacttttt tgtttagtct ttttcccaat     2940
gatctaatcc aaattgtccc ctcaaaaaac aaaacaatta aagctagaac aactgtatcg     3000
aaaaaagagg tattactacc ctcactcaca ggatatttta aaggtgttca tagtggaact     3060
gctgggatta ctgttgaaac acatgatggc agtattatag caaatgtagg ctccaagcag     3120
ttactatcat ttgagaaata ccaggtagat gtacttggac attacacaaa aattaagaag     3180
gaaaaacgta ttggaatggc aatatag                                         3207

<210>  9
<211>  3207
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 4 (Cas-Locus 4)-Bacillus species

<400>  9
ttgcaatatg tattaggatt ggatattgga atcgcatctt gtggttgggc tgtaatcaat       60
caagaaaaag agagaattga agatttaggg gttcgtattt ttgataaagc tgaaaatccc      120
aaagacggaa aatctttagc tgcacctagg cgtgacgcac gctctactag gagaacccta      180
cgccgtaaaa aacatagaat gctacggata aagatacttt tagtaaaaca aggcttacta      240
tctaagaacg aacttaacca tctatatgaa agtactactg aagtcgatgt ttggaactta      300
cgtttagatg ctctagaacg caaattgaat ccaaaagagt ttaccagagt tcttattcat      360
cttgctaaaa gaagaggatt taaatctaat agaaaagaaa ccactctctc agaaaacgga      420
caaatcttag aaagcatttc agagaatcaa cagattatgg agcaacaaaa ttatagaact      480
gttggagaaa tgattctaaa agataaaaaa tttgaaaacc ataaaagaaa caaagatggt      540
acttatatcg ggaccgttac ccgtcaacaa cttcaagaag aaatacaaat gatattcact      600
gcacaacgtt tgtacaaaaa cgattatgca acagaggaat ttgaaattag ctacttagaa      660
atctgggcat ctcaacgtcc ctatgcttct aaagatcaaa ttgaaaaaat gattggttac      720
tgtaccttag agccaaaaga aaaaagagtg cctaaagctt cttggtcatt tcaatatttt      780
gtagcgctac aaaccataaa caacctccga ctgatcagta aagacaggat agaagaactc      840
tctttcaaag aaaagaaaca aattatgaat ctagcacttg aaaaatcaat tgttaaatac      900
attgatatcc gaaaattatt atccattcct aatgaatttc agtttaatag cctatcatat      960
tcagctgata cagtagatac tacgttggag aataaaagat gtatagaact caaggaatat     1020
tactctatta acaaggtata taaacaaatt tatgagaaga acgccctaaa tttattacct     1080
atagattacg atacaattgc atacggacta actatcttta aagatgataa agatatcctt     1140
gaatatttac aaaataaata tgtaaatgca aaaggaaaac ctataaataa tttagctaaa     1200
aagacctacg attacacatt tattcaagca ttactgactc tgaatttcac gaaaatggga     1260
catttatcat ttaaagcttt aaaaaatatt attcctttct tagaagaagg gctatcatac     1320
gataaagcat gtgagaaggc aggatacaac tttaaaggaa catcctacac agaaaaaaca     1380
aagtacctac ctgttatccc tcaaaataca aatcctgttg tacatcgtgc tctttcacaa     1440
acaagaaaag ttataaatgc cattataaaa aaatatggtt ctccaaacgc aatccatatt     1500
gaaactgcaa gagaattatc gaaaacattc caagaaagaa aagaaataga tagtatgtac     1560
caggataact ctaaaaagaa tgaacacgcc attcataagt taaaagaatt ggggaacatt     1620
aacccctcag gaataaatat tgtgaaattt aagctttgga atgagcaaga tggtagatgt     1680
atgtattctg gaaaatatat cgaaccacat cggttatttg aagaaggtta tacggaagta     1740
gatcacatac tcccctatag ccgtagctta gatgatagct ataacaacaa aacattaaca     1800
ctaggaacag aaaatcagcg taaaggaaac aaaactcctt atgaatacat ggggaatact     1860
tcaatttgga atgactttga aacaagggta cattcaaata aaaaaatcaa caaaaagaaa     1920
caacaaaaat tacttttaca acacttttca tatgcgagag aacaagaatt tattgaacgc     1980
aatctgaatg atacccgtta tgccacaata tatctatcat cccttattca acaacacctc     2040
atattctctg aaagctctcg taagaaaaaa gttcatacag ttagtggaat tataacatct     2100
catttacgta gtagatgggg atttaacaaa gatcggaaag agggacatat tcatcatgct     2160
ttagatgcgg taatcgtcgc tgtcacatcc gatcacatga ttcaaagagt aacaaaatat     2220
tataagttaa aagagttaaa tagaaacctt caagccaaac ggatgccgtt tcctgaacct     2280
tgggaaggat ttcgtttaga gttagaagca aggatttctc caaataccca gcaatattta     2340
aagggatttc gttttaaaaa ttacgccgat gtcaacctat ccgaaatcaa acctatcttt     2400
gtttcaagaa tgcctaagcg ctctattact ggtgaattac atcaagaaac gattcggaaa     2460
ttcattggtt ataacgaaaa agggaaagta ttaaccgcaa taaaaacaaa attagaagat     2520
atcccttttg atgccaatgg tgattttccc atgtatggga aagaaactga tttatatacg     2580
tataatgcca taaaagaacg ttttttaagt cataaaaaag ataaacgcaa atcattccaa     2640
gaacctttat acaaacccac aaaatcagga ggaattggac cacttataaa atctattaaa     2700
ataattgata caagaaccat tgttaatcct gttaatcaag gtaaaggtgt cgtgtataat     2760
agtaaaattg ctcgtactga tgtattcaaa aaggatgaga agtactattt aattcccatt     2820
tacacaattg atcttatgaa aaatatctta cctcaaaaag caattacagc aggaaaagga     2880
tatgaggatt ggacaaccat tgatcctagc tttacttttt tatttagtct ttttcccaat     2940
gatctaattc aaattgtccc ctcaaaaaat aaaacaataa aagctagaac aactgtatcg     3000
aaaaaagagg tattactacc ctcactcaca ggatatttta aaggtgttca tagtggaact     3060
gcggggatta ctgttgaaac acacgatggc agtgttatag caaatgtagg ctcaaagcaa     3120
ttactattaa ttgagaaata tcaagtagat atacttggac attatacaaa aataaaggag     3180
gaaaaacgta ttgggatggc gatatag                                         3207

<210>  10
<211>  3207
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 5 (Cas-Locus 5)

<400>  10
ttgaaatatg tattagggtt ggatattgga attgcatcat gtggttgggc agtaataaat       60
caagaaaaac atagaattga agatttaggg gttcgtattt ttgataaagc tgagaatccc      120
aaagatggaa aatctttagc tacacctaga cgtgacgcac gttctaccag aagaacccta      180
cgccgtaaaa aacatagaat gcaacggata aagatacttt tagtaaagca cggcttacta      240
tccaagaccg aaatcgacca tctatatgaa agtgctactg agatcgatgt ttggtactta      300
cgtttaaatg ctctagagcg cagattaaat ccaaaagagt ttgctagagt tcttattcac      360
cttgctaaaa gaagaggatt taaatctaat agaaaagaaa caactctctc ggaaaacgga      420
aaaatcttag aaaatatttc agagaacctg cagattatgg agcaaaaaaa ttatagaact      480
gttggagaaa tgattctaaa agataaaaaa tttgaaaatc ataaaagaaa caaagatggt      540
acttatatcg ggactgttac tcggcaacaa cttcaagaag aaatacaaat gatattcaat      600
gcacaacgtt tgtacaaaaa caatcatgca acagagaaat ttgaaagtag ctacttagaa      660
atctgggcat ctcaacgtcc ctatgcttct aaagatcaaa ttgaaaaaat gattggttac      720
tgtaccttag agccaaaaga aaaaagagtg cctaaagctt cttggtcatt tcaatatttt      780
gtagcgctac aaaccataaa caacctccga ctgatcagta aagacaggat agaagaactc      840
tcttttgaag aaaagaaacg aattatgaat ctagcactcg aaaaatcaat tgttaaatac      900
attgatatcc gaaaattact atctgttcct aatgaatttc aatttaatag cctttcatat      960
tcagctgata tagtagatac aacggtggaa aataaaaaat gtatagaact caaagaatat     1020
cactctatta acaaggtata taaacaaatt tacgaacaga acgctctaaa tttattacct     1080
aaagattacg atacaattgc atacggactt actatcttta aagatgataa agatatccta     1140
gaatatttac aaaataaata cgtaaatgca aaaggaaaac ctataagtaa ttttgctaac     1200
aagacctacg atgatacatt tattcaggta ttattgactc tgaatttctc aaaaatggga     1260
catttatcat ttaaagcttt aaaaaatatt attccttttt tagaagaagg tctatcctac     1320
gataaagcat gtgagaaggc aggatacaac tttaagggaa catcctacac aaaaaaaaca     1380
aagtacctac ctgttatccc tcagaataca aatcctgttg tacatcgtgc tctttcacaa     1440
acaagaaaag ttataaatgc cattataaaa aaatatggtt ctccaaacgc aatccatatt     1500
gaaactgcaa gagaattatc gaaaacattt caagaaagaa aagaaataga tagtatgtac     1560
caggataact ctaaaaagaa tgaacacgcc attcataagt taaaagaatt ggggaacatt     1620
aacccctcag gaataaatat tgtgaaattt aagctttgga atgagcaaga tagtagatgt     1680
atgtattctg gaaaatatat cgaaccacat cgattatttg aagaaggtta tacggaagta     1740
gatcatatac tcccctatag ccggagctta gatgacagct ataacaataa agtgttaacg     1800
ctagggacag aaaatcaggg taaaggaaac agaactcctt atgaatacat ggggaatact     1860
tcaatttggg atgaatttga aacaagagta cagtcaaata aaaaaatcaa caaaaagaaa     1920
caacaaaaat tacttttaca aaacttttca catgcgagag aacaagaatt tattgaacgc     1980
aatctcaatg atacccgtta tgccacaata tatatatcat cccttattca acaacacctc     2040
atattctctg aaagctctcg tgagaaaaaa gttcatacag ttagtggaat tataacatct     2100
catttgcgta gtagatgggg atttaacaaa gatcggaaag aggggcatat ccatcatgct     2160
ttagatgcgg taatcgttgc tgtcacatcc gatcacatga ttcaaagagt aacaaaatat     2220
tataagttaa aagaattaaa tagaaaccgt caagccaaac ggatgcagtt tcctgaacct     2280
tgggaaggat ttcgtttaga gttagaagca aggatttctc caaataccca gcaatactta     2340
aagggaattc gtttaaaaaa ttacgccgat gtcaatctat ctgaaatcaa acctatcttt     2400
gtttcaagaa tgcctaagcg ctctattact ggtgaattac atcaagaaac aatccggaaa     2460
ttccttggtt ataacgaaaa agggaaagtg ctaaccgcaa taaaaacaaa attagaagat     2520
attccttttg atgctaatgg tgattttccc atgtatggaa aagaaactga tttatatacg     2580
tataatgcca taaaagaacg ttatttaagt cataaaaaag ataaacgcaa atcattccaa     2640
gaacctttat acaaacccac aaaatcagga ggaattggac cacttataaa atctattaaa     2700
ataatggata caagaaccat tgttaatcct gttaatcaag gtaaaggtgt cgtgtataat     2760
agtaaaattg ctcgcactga tgtattcaaa aaggctgaaa agtactattt aattcccatt     2820
tacacaattg atcttatgaa aaatatctta cctcaaaaag caattacagc aggaaaagga     2880
tatgaggatt ggacaaccat tgatcctagc tttacttttt tgtttagtct ttttcccaat     2940
gatctaatcc aaattgtccc ctcaaaaaat aaaataatta aagctagaac aactgtatcg     3000
aaaaaagagg tattactacc ctcactcaca ggatatttta aaggtgttca tagtggaact     3060
gctgggatta ctgttgaaac acacgatggc agtattatag caaatgtagg ctccaagcag     3120
ttactatcat ttgagaaata ccaggtagat gtacttggac attacacaaa aattaagaag     3180
gaaaaacgta ttggaatggc aatatag                                         3207

<210>  11
<211>  1070
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 1 (Bacillus species)

<400>  11
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      
Ile Gly Trp Gly Ile Ile Glu Leu Ser Trp Asn Lys Asp Arg Glu Gln 
            20                  25                  30          
Tyr Glu Lys Ala Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              
Ala Glu Ile Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Leu 
    50                  55                  60                  
Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  
Asp Ile Arg Asn Leu Leu Val Gln His Glu Ile Ile Ser Gln Arg Glu 
                85                  90                  95      
Leu Ala Ser Leu Tyr Pro Leu Ser Lys Ser Ser Met Asp Ile Trp Asp 
            100                 105                 110         
Ile Arg Leu Glu Gly Leu Asp Arg Leu Leu Asp His Phe Glu Trp Thr 
        115                 120                 125             
Arg Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 
Lys Ser Glu Leu Lys Asp Val Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 
Gln Ala Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     
Trp Met Lys Asn Glu Asp Phe Ser Lys Tyr Asp Lys Arg Arg Asn Ser 
            180                 185                 190         
Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu 
        195                 200                 205             
Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala 
    210                 215                 220                 
Ser Val Asp Leu Gln Lys Thr Tyr Leu Gln Ile Trp Ala His Gln Leu 
225                 230                 235                 240 
Pro Phe Ala Ser Gly Asn Ala Ile Val Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     
Leu Leu Lys Gly Lys Glu Lys Arg Val Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         
Gln Tyr Phe Ser Thr Leu Asp Gln Ile Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             
Asn Phe Gln Pro Phe Thr Lys Glu Gln Arg Asp Ile Ile Leu Asp Lys 
    290                 295                 300                 
Met Phe Asn Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 
Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Ala Leu Asp Glu Thr Ile Gln 
                325                 330                 335     
Phe Lys Gly Leu Thr Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         
Leu Lys Ser Phe Ile Asn Leu Lys Pro Phe Tyr Glu Ile Lys Gln Val 
        355                 360                 365             
Val Thr Asn Tyr Ala Lys Lys Ile Asn Glu Ala Phe Ser Thr Leu Asp 
    370                 375                 380                 
Tyr Asp Thr Phe Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 
Ile Arg Ser Tyr Leu Lys Lys Ser Asn Asn Leu Ser Lys Cys Cys Tyr 
                405                 410                 415     
Asp Asp Gln Leu Ile Glu Glu Leu Leu Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         
Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             
Glu Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 
Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro 
465                 470                 475                 480 
Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     
Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         
His Ile Glu Leu Ala Arg Glu Leu Pro Lys Asn His Asp Glu Arg Thr 
        515                 520                 525             
Lys Ile Met Lys Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 
Ile Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 
Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Val Tyr 
                565                 570                 575     
Ser Leu Lys Gln Ile Pro Ala Asn Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         
Glu Arg Ser Gly Pro Pro Val Leu Glu Ile Asp His Ile Leu Pro Tyr 
        595                 600                 605             
Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Glu 
    610                 615                 620                 
Glu Glu Asn Gln Lys Lys Gly Asn Arg Ile Pro Tyr Thr Tyr Phe Leu 
625                 630                 635                 640 
Glu Glu Asn Lys Asp Trp Glu Ser Phe Glu Ser Tyr Val Arg Leu Asn 
                645                 650                 655     
Ser Phe Leu Ser Lys Lys Lys Arg Gly Tyr Leu Leu Lys Lys Ala Tyr 
            660                 665                 670         
Leu Pro Arg Glu Ser Asn Met Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             
Arg Tyr Ala Ser Ser Tyr Leu Lys Asn Phe Ile Glu Lys Asn Leu Lys 
    690                 695                 700                 
Phe Lys Glu Val Glu Gly Ser Thr Arg Asn Lys His Val Gln Thr Val 
705                 710                 715                 720 
Asn Gly Ile Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     
Asp Arg Lys Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         
Ala Cys Thr Asp His His Met Val Thr Lys Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             
Ile Lys Glu Ser Asn Lys Ser Ile Lys Lys Pro Tyr Phe Pro Leu Pro 
    770                 775                 780                 
Trp Val Gly Phe Arg Glu Glu Ile Leu Ser His Leu Ala Arg Gln Pro 
785                 790                 795                 800 
Ile Ala Arg Lys Ile Ser Glu Glu Leu Lys Ile Gly Tyr Gln Ser Phe 
                805                 810                 815     
Asp Tyr Ile Leu Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ser 
            820                 825                 830         
Ala His Glu Gln Thr Ile Met Lys Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             
Lys Thr Ile Ile Ile Lys Arg Val Tyr Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 
Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 
Tyr Glu Ala Ile Lys Gln Arg Tyr Ile Glu Tyr Gly Lys Glu Ser Lys 
                885                 890                 895     
Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Lys Gly 
            900                 905                 910         
Asn Leu Ile Lys Lys Ile Lys Val Glu Val Gln Thr Lys Ser Phe Val 
        915                 920                 925             
Arg Glu Val Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Val 
    930                 935                 940                 
Asp Leu Phe Glu Lys Asp Asn Arg Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 
Met Asp Thr Val His Ser Glu Leu Pro Asn Lys Ala Val Thr Ser Ser 
                965                 970                 975     
Lys Gly Tyr Glu Gln Trp Leu Thr Ile Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         
Phe Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asp Glu 
        995                 1000                 1005             
Asp Arg  Phe Leu Tyr Phe Ser  Thr Leu Asp Ile Asn  Ser Asp Arg 
    1010                 1015                 1020             
Leu Asn  Phe Lys Asp Val Asn  Thr Pro Ser Lys Gln  Ala Glu Asn 
    1025                 1030                 1035             
Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             
Gly Val  Leu Gly Asp Leu Arg  Phe Val Arg Gln Glu  Ile Arg Lys 
    1055                 1060                 1065             
Asn Phe  
    1070 

<210>  12
<211>  1070
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 2 (Bacillus species)

<400>  12
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      
Ile Gly Trp Gly Val Val Glu Leu Ser Trp Asn Lys Asp Arg Glu Gln 
            20                  25                  30          
Tyr Glu Lys Ala Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              
Ala Glu Ile Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Thr 
    50                  55                  60                  
Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  
Asp Ile Arg Asn Leu Leu Val Gln His Glu Ile Ile Ser Gln Lys Glu 
                85                  90                  95      
Leu Ala Ser Leu Tyr Pro Leu Ser Lys Ser Ser Met Asp Ile Trp Asp 
            100                 105                 110         
Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asp Arg Leu Glu Trp Thr 
        115                 120                 125             
Arg Leu Leu Ile His Leu Ala Gln Lys Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 
Lys Ser Glu Leu Lys Asp Val Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 
Gln Val Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     
Trp Met Lys Asn Glu Asp Phe Ser Lys Tyr Asp Lys Arg Arg Asn Ser 
            180                 185                 190         
Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asn Leu Glu Lys Glu 
        195                 200                 205             
Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala 
    210                 215                 220                 
Ser Val Asp Leu Gln Lys Thr Tyr Leu Gln Ile Trp Ala His Gln Leu 
225                 230                 235                 240 
Pro Phe Ala Ser Gly Asn Ala Ile Val Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     
Leu Leu Lys Gly Lys Glu Lys Arg Val Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         
Gln Tyr Phe Ser Thr Leu Asp Gln Ile Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             
Asn Phe Gln Pro Phe Thr Lys Glu Gln Arg Asp Ile Ile Leu Asp Lys 
    290                 295                 300                 
Met Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 
Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Ala Leu Asp Glu Thr Ile Gln 
                325                 330                 335     
Phe Lys Gly Leu Thr Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         
Met Lys Leu Phe Ile Asn Leu Lys Pro Phe Tyr Glu Ile Lys Lys Val 
        355                 360                 365             
Val Thr Asn Tyr Ala Lys Lys Thr Asn Glu Val Phe Ser Thr Leu Asp 
    370                 375                 380                 
Tyr Asp Thr Val Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 
Ile Ile Ser Tyr Leu Lys Arg Ser Asn Asn Leu Ser Lys Arg Cys Tyr 
                405                 410                 415     
Asp Asp Gln Leu Ile Glu Glu Leu Leu Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         
Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             
Glu Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 
Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro 
465                 470                 475                 480 
Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     
Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         
His Ile Glu Leu Ala Arg Glu Leu Ser Lys Thr His Asp Glu Arg Thr 
        515                 520                 525             
Lys Ile Met Lys Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 
Ile Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 
Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     
Ser Leu Lys Gln Ile His Ala Asn Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         
Glu Arg Ser Gly Pro Pro Val Leu Glu Ile Asp His Ile Leu Pro Tyr 
        595                 600                 605             
Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Gly 
    610                 615                 620                 
Asp Glu Asn Gln Lys Lys Gly Asn Arg Ile Pro Tyr Thr Tyr Phe Leu 
625                 630                 635                 640 
Glu Gly Asn Lys Asp Trp Glu Ser Phe Glu Ser Tyr Val Arg Leu Asn 
                645                 650                 655     
Ser Leu Phe Ser Lys Lys Lys Arg Gly Tyr Leu Leu Lys Lys Ala Tyr 
            660                 665                 670         
Leu Pro Arg Glu Ser Asn Met Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             
Arg Tyr Ala Ser Ser Tyr Leu Lys Asn Phe Ile Glu Lys Asn Leu Lys 
    690                 695                 700                 
Phe Lys Glu Val Glu Gly Ser Thr Arg Lys Lys His Val Gln Thr Val 
705                 710                 715                 720 
Asn Gly Ile Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     
Asp Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         
Ala Cys Thr Asp His His Met Val Thr Lys Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             
Ile Lys Glu Ser Asn Lys Ser Ile Lys Lys Pro Tyr Phe Pro Leu Pro 
    770                 775                 780                 
Trp Val Ala Phe Arg Glu Glu Ile Leu Ser His Leu Ala Arg Gln Pro 
785                 790                 795                 800 
Ile Ala Arg Lys Ile Ser Glu Glu Leu Lys Ile Gly Tyr Gln Ser Phe 
                805                 810                 815     
Asp Tyr Ile Leu Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala 
            820                 825                 830         
Ala His Glu Gln Thr Ile Met Lys Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             
Lys Thr Ile Ile Ile Lys Arg Val Tyr Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 
Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 
Tyr Glu Ala Ile Lys Gln Arg Tyr Ile Glu Tyr Gly Lys Glu Ser Lys 
                885                 890                 895     
Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Lys Gly 
            900                 905                 910         
Asn Leu Ile Lys Lys Ile Lys Val Glu Val Gln Thr Lys Ser Phe Val 
        915                 920                 925             
Arg Glu Val Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Val 
    930                 935                 940                 
Asp Leu Phe Glu Lys Asp Asn Arg Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 
Met Asp Thr Val His Ser Glu Leu Pro Asn Lys Ala Val Thr Ser Ser 
                965                 970                 975     
Lys Gly Tyr Glu Lys Trp Leu Thr Ile Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         
Phe Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asp Glu 
        995                 1000                 1005             
Asp Arg  Phe Leu Tyr Phe Ser  Thr Leu Asp Ile Asn  Ser Asp Arg 
    1010                 1015                 1020             
Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Gln  Ala Glu Asn 
    1025                 1030                 1035             
Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             
Gly Val  Leu Gly Asp Leu Arg  Phe Val Arg Gln Glu  Ile Arg Lys 
    1055                 1060                 1065             
Asn Phe  
    1070 

<210>  13
<211>  1068
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 3 (Bacillus species)

<400>  13
Met Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          
Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Thr 
        35                  40                  45              
Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly Leu Leu 
65                  70                  75                  80  
Ser Lys Thr Glu Ile Asp His Leu Tyr Glu Ser Ala Thr Glu Ile Asp 
                85                  90                  95      
Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu Arg Arg Leu Asn Pro Lys 
            100                 105                 110         
Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             
Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 
Asn Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr Arg Thr 
145                 150                 155                 160 
Val Gly Glu Met Ile Leu Lys Asp Lys Arg Phe Glu Asn His Lys Arg 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         
Glu Glu Ile Gln Met Ile Phe Asn Ala Gln Arg Leu Tyr Lys Asn Asn 
        195                 200                 205             
His Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 
Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 
Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser 
                245                 250                 255     
Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         
Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Arg Ile 
        275                 280                 285             
Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 
Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 
Ser Ala Asp Ile Val Asp Thr Thr Val Glu Asn Lys Lys Cys Ile Glu 
                325                 330                 335     
Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly 
            340                 345                 350         
Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             
Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 
Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Leu Ala Asn 
385                 390                 395                 400 
Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu Asn Phe 
                405                 410                 415     
Ser Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         
Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             
Tyr Asn Phe Lys Gly Ala Ser Tyr Thr Lys Lys Thr Lys Tyr Leu Pro 
    450                 455                 460                 
Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 
Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     
Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         
Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             
His Ala Ile Cys Lys Leu Lys Glu Leu Gly Asn Ile Lys Pro Ser Gly 
    530                 535                 540                 
Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 
Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     
Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         
Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             
Gly Asn Lys Thr Pro Tyr Glu Tyr Met Arg Asn Asn Ser Ile Trp Asp 
    610                 615                 620                 
Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 
Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu Gln Glu 
                645                 650                 655     
Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         
Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Glu 
        675                 680                 685             
Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 
Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 
Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg 
                725                 730                 735     
Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Ile Gln Ala 
            740                 745                 750         
Lys Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             
Glu Ala Arg Val Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile Arg 
    770                 775                 780                 
Phe Lys Asn Tyr Ala Asp Val Asp Leu Ser Glu Ile Lys Pro Ile Phe 
785                 790                 795                 800 
Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     
Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         
Ala Thr Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             
Phe Pro Met Phe Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 
Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 
Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     
Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         
Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             
Phe Lys Lys Gly Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 
Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 
Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     
Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         
Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             
Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             
Thr Val  Glu Thr His Asp Gly  Ser Ile Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             
Lys Gln  Leu Leu Ser Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             
His Tyr  Thr Lys Ile Lys Lys  Glu Lys Arg Ile Gly  Met Ala Ile 
    1055                 1060                 1065             

<210>  14
<211>  1068
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 4 (Bacillus species)

<400>  14
Met Gln Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Val Ile Asn Gln Glu Lys Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          
Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              
Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Met Leu Arg Ile Lys Ile Leu Leu Val Lys Gln Gly Leu Leu 
65                  70                  75                  80  
Ser Lys Asn Glu Leu Asn His Leu Tyr Glu Ser Thr Thr Glu Val Asp 
                85                  90                  95      
Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu Asn Pro Lys 
            100                 105                 110         
Glu Phe Thr Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             
Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 
Ser Ile Ser Glu Asn Gln Gln Ile Met Glu Gln Gln Asn Tyr Arg Thr 
145                 150                 155                 160 
Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         
Glu Glu Ile Gln Met Ile Phe Thr Ala Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             
Tyr Ala Thr Glu Glu Phe Glu Ile Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 
Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 
Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser 
                245                 250                 255     
Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         
Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Lys Glu Lys Lys Gln Ile 
        275                 280                 285             
Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 
Lys Leu Leu Ser Ile Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 
Ser Ala Asp Thr Val Asp Thr Thr Leu Glu Asn Lys Arg Cys Ile Glu 
                325                 330                 335     
Leu Lys Glu Tyr Tyr Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Glu 
            340                 345                 350         
Lys Asn Ala Leu Asn Leu Leu Pro Ile Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             
Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 
Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Asn Asn Leu Ala Lys 
385                 390                 395                 400 
Lys Thr Tyr Asp Tyr Thr Phe Ile Gln Ala Leu Leu Thr Leu Asn Phe 
                405                 410                 415     
Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         
Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             
Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Lys Thr Lys Tyr Leu Pro 
    450                 455                 460                 
Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 
Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     
Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         
Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             
His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 
Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 
Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     
Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         
Ser Tyr Asn Asn Lys Thr Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             
Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asn 
    610                 615                 620                 
Asp Phe Glu Thr Arg Val His Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 
Gln Gln Lys Leu Leu Leu Gln His Phe Ser Tyr Ala Arg Glu Gln Glu 
                645                 650                 655     
Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         
Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Lys 
        675                 680                 685             
Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 
Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 
Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg 
                725                 730                 735     
Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Leu Gln Ala 
            740                 745                 750         
Lys Arg Met Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             
Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Phe Arg 
    770                 775                 780                 
Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Pro Ile Phe 
785                 790                 795                 800 
Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     
Thr Ile Arg Lys Phe Ile Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         
Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             
Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 
Lys Glu Arg Phe Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 
Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     
Lys Ser Ile Lys Ile Ile Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         
Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             
Phe Lys Lys Asp Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 
Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 
Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     
Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         
Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             
Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             
Thr Val  Glu Thr His Asp Gly  Ser Val Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             
Lys Gln  Leu Leu Leu Ile Glu  Lys Tyr Gln Val Asp  Ile Leu Gly 
    1040                 1045                 1050             
His Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Ile Gly  Met Ala Ile 
    1055                 1060                 1065             

<210>  15
<211>  1068
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 5

<400>  15
Met Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          
Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Thr 
        35                  40                  45              
Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly Leu Leu 
65                  70                  75                  80  
Ser Lys Thr Glu Ile Asp His Leu Tyr Glu Ser Ala Thr Glu Ile Asp 
                85                  90                  95      
Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu Arg Arg Leu Asn Pro Lys 
            100                 105                 110         
Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             
Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Lys Ile Leu Glu 
    130                 135                 140                 
Asn Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr Arg Thr 
145                 150                 155                 160 
Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         
Glu Glu Ile Gln Met Ile Phe Asn Ala Gln Arg Leu Tyr Lys Asn Asn 
        195                 200                 205             
His Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 
Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 
Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser 
                245                 250                 255     
Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         
Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Arg Ile 
        275                 280                 285             
Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 
Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 
Ser Ala Asp Ile Val Asp Thr Thr Val Glu Asn Lys Lys Cys Ile Glu 
                325                 330                 335     
Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Glu 
            340                 345                 350         
Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             
Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 
Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Phe Ala Asn 
385                 390                 395                 400 
Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu Asn Phe 
                405                 410                 415     
Ser Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         
Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             
Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Lys Lys Thr Lys Tyr Leu Pro 
    450                 455                 460                 
Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 
Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     
Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         
Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             
His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 
Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Ser Arg Cys 
545                 550                 555                 560 
Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     
Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         
Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly Thr Glu Asn Gln Gly Lys 
        595                 600                 605             
Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asp 
    610                 615                 620                 
Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 
Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu Gln Glu 
                645                 650                 655     
Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Ile 
            660                 665                 670         
Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Glu 
        675                 680                 685             
Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 
Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 
Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg 
                725                 730                 735     
Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Arg Gln Ala 
            740                 745                 750         
Lys Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             
Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile Arg 
    770                 775                 780                 
Leu Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Pro Ile Phe 
785                 790                 795                 800 
Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     
Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         
Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             
Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 
Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 
Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     
Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         
Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             
Phe Lys Lys Ala Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 
Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 
Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     
Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Ile 
            980                 985                 990         
Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             
Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             
Thr Val  Glu Thr His Asp Gly  Ser Ile Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             
Lys Gln  Leu Leu Ser Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             
His Tyr  Thr Lys Ile Lys Lys  Glu Lys Arg Ile Gly  Met Ala Ile 
    1055                 1060                 1065             

<210>  16
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 1 (Bacillus species)

<400>  16
atcataatac agcaatggct twaatggaac tatgac                                 36

<210>  17
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 2 (Bacillus species)

<400>  17
atcataaaac agcaatggct taaatggaac tatgac                                 36

<210>  18
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 3 (Bacillus species)

<400>  18
accatagcat agcgatgttt cttatggaac tatagc                                 36

<210>  19
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 4 (Bacillus species)

<400>  19
atcatatcat agcgatrttt cttatggaac tatagc                                 36

<210>  20
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 5

<400>  20
accatagcat agcgatgttt cttatggaac tatagc                                 36

<210>  21
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti repeat Locus 1

<400>  21
atcataatac agcaatggct ttgatgtttc tatgat                                 36

<210>  22
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti repeat Locus 2

<400>  22
atcataaaac agcaatggct ttgatgtttc tatgat                                 36

<210>  23
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti repeat Locus 3

<400>  23
atcatatcat agcgatgttt cttaagttac tatagt                                 36

<210>  24
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti repeat Locus 4

<400>  24
atcatatcat agcgatgttt cttaagttac tatagt                                 36

<210>  25
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti repeat Locus 5

<400>  25
atcatatcat agcgatgttt cttaagttac tatagt                                 36

<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 1

<400>  26
gucauaguuc cauuwaagc                                                    19

<210>  27
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 2

<400>  27
gucauaguuc cauuuaagc                                                    19

<210>  28
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 3

<400>  28
gcuauaguuc cauaagaaac                                                   20

<210>  29
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 4

<400>  29
gcuauaguuc cauaagaaay                                                   20

<210>  30
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 5

<400>  30
gcuauaguuc cauaagaaac                                                   20

<210>  31
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 1

<400>  31
gcuuugaugu uucuaugau                                                    19

<210>  32
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 2

<400>  32
gcuuugaugu uucuaugau                                                    19

<210>  33
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 3

<400>  33
guuucuuaag uuacuauagu                                                   20

<210>  34
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 4

<400>  34
guuucuuaag uuacuauagu                                                   20

<210>  35
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 5

<400>  35
guuucuuaag uuacuauagu                                                   20

<210>  36
<211>  114
<212>  RNA
<213>  Artificial sequence

<220>
<223>   3 prime tracrRNA for Cas-Locus 1

<400>  36
aagggcuuag gcccguggcg uuggggaucg ccugcccauu uuaaugggcu ucuccccacc       60
uauuuaauga gaauuuuaca accuuggcua uucuuaaaua gcuaagguuu uuuu            114

<210>  37
<211>  114
<212>  RNA
<213>  Artificial sequence

<220>
<223>   3 prime tracrRNA for Cas-Locus 2

<400>  37
aagggcuuag gcccguggcg uuggggaucg ccugcccauu uuuaugggcu ucuccccauc       60
uauuuaauga aaauuuuaca accuuggcua uucuuaaaua gcuaagguuu uuuu            114

<210>  38
<211>  101
<212>  RNA
<213>  Artificial sequence

<220>
<223>   3 prime tracrRNA for Cas-Locus 3

<400>  38
aagggcaaug acccguggcg uuuggggauc gccuuauccu gguauggaua uucuccccau       60
gugaaaagca ccuaagcaua gcgcuauggu gcuuuuauuu u                          101

<210>  39
<211>  100
<212>  RNA
<213>  Artificial sequence

<220>
<223>   3 prime tracrRNA for Cas-Locus 4

<400>  39
aagggcaaug acccguggcg uuuggagauc gccucaucca uuacggauau ucuccccaug       60
ugaaaagcac cuaagcauaa ggcuaaggug cuuuuauuuu                            100

<210>  40
<211>  101
<212>  RNA
<213>  Artificial sequence

<220>
<223>   3 prime tracrRNA for Cas-Locus 5

<400>  40
aagggcaaug acccguggcg uuuggggauc gccuuauccu gguauggaua uucuccccau       60
gugaaaagca ccuaagcaua gcgcuauggu gcuuuuauuu u                          101

<210>  41
<211>  176
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 1

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  41
nnnnnnnnnn nnnnnnnnnn gucauaguuc cauuwaagcg aaagcuuuga uguuucuaug       60
auaagggcuu aggcccgugg cguuggggau cgccugccca uuuuaauggg cuucucccca      120
ccuauuuaau gagaauuuua caaccuuggc uauucuuaaa uagcuaaggu uuuuuu          176

<210>  42
<211>  176
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 2

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  42
nnnnnnnnnn nnnnnnnnnn gucauaguuc cauuuaagcg aaagcuuuga uguuucuaug       60
auaagggcuu aggcccgugg cguuggggau cgccugccca uuuuuauggg cuucucccca      120
ucuauuuaau gaaaauuuua caaccuuggc uauucuuaaa uagcuaaggu uuuuuu          176

<210>  43
<211>  165
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 3

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  43
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaagaaac gaaaguuucu uaaguuacua       60
uaguaagggc aaugacccgu ggcguuuggg gaucgccuua uccugguaug gauauucucc      120
ccaugugaaa agcaccuaag cauagcgcua uggugcuuuu auuuu                      165

<210>  44
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 4

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  44
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaagaaay gaaaguuucu uaaguuacua       60
uaguaagggc aaugacccgu ggcguuugga gaucgccuca uccauuacgg auauucuccc      120
caugugaaaa gcaccuaagc auaaggcuaa ggugcuuuua uuuu                       164

<210>  45
<211>  165
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 5

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  45
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaagaaac gaaaguuucu uaaguuacua       60
uaguaagggc aaugacccgu ggcguuuggg gaucgccuua uccugguaug gauauucucc      120
ccaugugaaa agcaccuaag cauagcgcua uggugcuuuu auuuu                      165

<210>  46
<211>  3213
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 3 (Cas-Locus 3)  open reading frame 
       (ORF)-2 from Bacillus species

<400>  46
atgaaattga aatatgtatt agggttggat attggaatcg catcatgtgg ttgggcagta       60
ataaatcaag aaaaacatag aattgaagat ttaggggttc gtatttttga taaagctgag      120
aatcccaaag atggaaaatc tttagctaca cctagacgtg acgcacgctc taccagaaga      180
accctacgcc gtaaaaaaca tagaatgcaa cggataaaga tacttttagt aaagcacggc      240
ttactatcca agaccgaaat cgaccatcta tatgaaagtg ctactgagat cgatgtttgg      300
tacttacgtt taaatgctct agagcgcaga ttaaatccaa aagagtttgc tagagttctt      360
attcaccttg ctaaaagaag aggatttaaa tctaatagaa aagaaacaac tctctcggaa      420
aacggacaaa tcttagaaaa tatttcagag aacctgcaga ttatggagca aaaaaattat      480
agaactgttg gagaaatgat tctaaaagat aaaagatttg aaaatcataa aagaaacaaa      540
gatggtactt atatcgggac tgttactcgg caacaacttc aagaagaaat acaaatgata      600
ttcaatgcac aacgtttgta caaaaacaat catgcaacag agaaatttga aagtagctac      660
ttagaaatct gggcatctca acgtccctat gcttctaaag atcaaattga aaaaatgatt      720
ggttactgta ccttagagcc aaaagaaaaa agagtgccta aagcttcttg gtcatttcaa      780
tattttgtag cgctacaaac cataaacaac ctccgactga tcagtaaaga caggatagaa      840
gaactctctt ttgaagaaaa gaaacgaatt atgaatctag cactcgaaaa atcaattgtt      900
aaatacattg atatccgaaa attactatct gttcctaatg aatttcaatt taatagcctt      960
tcatattcag ctgatatagt agatacaacg gtggaaaata aaaaatgtat agaactcaaa     1020
gaatatcact ctattaacaa ggtatataaa caaatttacg gacagaacgc tctaaattta     1080
ttacctaaag attacgatac aattgcatac ggacttacta tctttaaaga tgataaagat     1140
atcctagaat atttacaaaa taaatacgta aatgcaaaag gaaaacctat aagtaattta     1200
gctaacaaga cctacgatga tacatttatt caggtattat tgactctgaa tttctcaaaa     1260
atgggacatt tatcatttaa agctttaaaa aatattattc cttttttaga agaaggtcta     1320
tcctacgata aagcatgtga gaaggcagga tacaacttta agggagcatc ctacacaaaa     1380
aaaacaaagt acctacctgt tatccctcag aatacaaatc ctgttgtaca tcgtgctctt     1440
tcacaaacaa gaaaagttat aaatgccatt ataaaaaaat atggttctcc aaacgcaatc     1500
catattgaaa ctgcaagaga attatcgaaa acattccaag aaagaaaaga aatagatagt     1560
atgtaccagg ataactctaa aaagaatgaa cacgccattt gtaagttaaa agaattgggg     1620
aatattaaac cctcaggaat aaatattgtg aaatttaagc tttggaacga gcaagatggt     1680
agatgtatgt attctggaaa atatattgaa ccacatcgct tatttgaaga aggttatacg     1740
gaagtagatc atatactccc ttacagccgt agcttagatg acagctataa caataaagta     1800
ttaacgctag gaacagaaaa tcagcgtaaa ggaaacaaaa ctccttatga atacatgagg     1860
aataattcaa tttgggatga atttgaaaca agagtacagt caaataaaaa aatcaacaaa     1920
aagaaacaac aaaaattact tttacaaaac ttttcacatg cgagagaaca agaatttatt     1980
gaacgcaatc tcaatgatac ccgttatgcc acaatatatc tatcatccct tattcaacaa     2040
cacctcatat tctctgaaag ctctcgtgag aaaaaagttc atacagttag tggaattata     2100
acatctcatt tgcgtagtag atggggattt aacaaagatc ggaaagaggg gcatatccat     2160
catgctttag atgcggtaat cgttgctgtc acatccgatc acatgattca aagagtaaca     2220
aaatattata agttaaaaga gttaaataga aatattcaag ccaaacggat gcagtttcct     2280
gaaccttggg aaggatttcg tttagagtta gaagcaagag tttctccaaa tacccagcaa     2340
tatttaaagg gtattcgttt taaaaattac gccgatgtcg atctatccga aatcaaacct     2400
atctttgttt caagaatgcc taagcgctct attactggtg aattacatca agaaacaatc     2460
cggaaattcc ttggttataa cgaaaagggg aaagtgctaa ccgcgacaaa aacaaaatta     2520
gaagatattc cttttgatgc taatggtgat tttcccatgt ttggaaaaga aactgattta     2580
tatacgtata atgccataaa agaacgttat ttaagtcata aaaaagataa acgcaaatca     2640
ttccaagagc ctttatacaa acccacaaaa tcaggaggaa ttggaccact tataaaatct     2700
attaaaataa tggatacaag aaccattgtt aatcctgtta atcaaggtaa aggtgtcgtg     2760
tataatagta aaattgctcg tactgatgta ttcaaaaagg gtgagaagta ctatttaatt     2820
cccatttaca caattgatct tatgaaaaat atcttacctc aaaaagcaat tacagcagga     2880
aaaggatatg aggattggac aactattgat cctagcttta cttttttgtt tagtcttttt     2940
cccaatgatc taatccaaat tgtcccctca aaaaacaaaa caattaaagc tagaacaact     3000
gtatcgaaaa aagaggtatt actaccctca ctcacaggat attttaaagg tgttcatagt     3060
ggaactgctg ggattactgt tgaaacacat gatggcagta ttatagcaaa tgtaggctcc     3120
aagcagttac tatcatttga gaaataccag gtagatgtac ttggacatta cacaaaaatt     3180
aagaaggaaa aacgtattgg aatggcaata tag                                  3213

<210>  47
<211>  3225
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 3 (Cas-Locus 3) ORF3, from Bacillus 
       species

<400>  47
atgaaggagg ttatgaaatt gaaatatgta ttagggttgg atattggaat cgcatcatgt       60
ggttgggcag taataaatca agaaaaacat agaattgaag atttaggggt tcgtattttt      120
gataaagctg agaatcccaa agatggaaaa tctttagcta cacctagacg tgacgcacgc      180
tctaccagaa gaaccctacg ccgtaaaaaa catagaatgc aacggataaa gatactttta      240
gtaaagcacg gcttactatc caagaccgaa atcgaccatc tatatgaaag tgctactgag      300
atcgatgttt ggtacttacg tttaaatgct ctagagcgca gattaaatcc aaaagagttt      360
gctagagttc ttattcacct tgctaaaaga agaggattta aatctaatag aaaagaaaca      420
actctctcgg aaaacggaca aatcttagaa aatatttcag agaacctgca gattatggag      480
caaaaaaatt atagaactgt tggagaaatg attctaaaag ataaaagatt tgaaaatcat      540
aaaagaaaca aagatggtac ttatatcggg actgttactc ggcaacaact tcaagaagaa      600
atacaaatga tattcaatgc acaacgtttg tacaaaaaca atcatgcaac agagaaattt      660
gaaagtagct acttagaaat ctgggcatct caacgtccct atgcttctaa agatcaaatt      720
gaaaaaatga ttggttactg taccttagag ccaaaagaaa aaagagtgcc taaagcttct      780
tggtcatttc aatattttgt agcgctacaa accataaaca acctccgact gatcagtaaa      840
gacaggatag aagaactctc ttttgaagaa aagaaacgaa ttatgaatct agcactcgaa      900
aaatcaattg ttaaatacat tgatatccga aaattactat ctgttcctaa tgaatttcaa      960
tttaatagcc tttcatattc agctgatata gtagatacaa cggtggaaaa taaaaaatgt     1020
atagaactca aagaatatca ctctattaac aaggtatata aacaaattta cggacagaac     1080
gctctaaatt tattacctaa agattacgat acaattgcat acggacttac tatctttaaa     1140
gatgataaag atatcctaga atatttacaa aataaatacg taaatgcaaa aggaaaacct     1200
ataagtaatt tagctaacaa gacctacgat gatacattta ttcaggtatt attgactctg     1260
aatttctcaa aaatgggaca tttatcattt aaagctttaa aaaatattat tcctttttta     1320
gaagaaggtc tatcctacga taaagcatgt gagaaggcag gatacaactt taagggagca     1380
tcctacacaa aaaaaacaaa gtacctacct gttatccctc agaatacaaa tcctgttgta     1440
catcgtgctc tttcacaaac aagaaaagtt ataaatgcca ttataaaaaa atatggttct     1500
ccaaacgcaa tccatattga aactgcaaga gaattatcga aaacattcca agaaagaaaa     1560
gaaatagata gtatgtacca ggataactct aaaaagaatg aacacgccat ttgtaagtta     1620
aaagaattgg ggaatattaa accctcagga ataaatattg tgaaatttaa gctttggaac     1680
gagcaagatg gtagatgtat gtattctgga aaatatattg aaccacatcg cttatttgaa     1740
gaaggttata cggaagtaga tcatatactc ccttacagcc gtagcttaga tgacagctat     1800
aacaataaag tattaacgct aggaacagaa aatcagcgta aaggaaacaa aactccttat     1860
gaatacatga ggaataattc aatttgggat gaatttgaaa caagagtaca gtcaaataaa     1920
aaaatcaaca aaaagaaaca acaaaaatta cttttacaaa acttttcaca tgcgagagaa     1980
caagaattta ttgaacgcaa tctcaatgat acccgttatg ccacaatata tctatcatcc     2040
cttattcaac aacacctcat attctctgaa agctctcgtg agaaaaaagt tcatacagtt     2100
agtggaatta taacatctca tttgcgtagt agatggggat ttaacaaaga tcggaaagag     2160
gggcatatcc atcatgcttt agatgcggta atcgttgctg tcacatccga tcacatgatt     2220
caaagagtaa caaaatatta taagttaaaa gagttaaata gaaatattca agccaaacgg     2280
atgcagtttc ctgaaccttg ggaaggattt cgtttagagt tagaagcaag agtttctcca     2340
aatacccagc aatatttaaa gggtattcgt tttaaaaatt acgccgatgt cgatctatcc     2400
gaaatcaaac ctatctttgt ttcaagaatg cctaagcgct ctattactgg tgaattacat     2460
caagaaacaa tccggaaatt ccttggttat aacgaaaagg ggaaagtgct aaccgcgaca     2520
aaaacaaaat tagaagatat tccttttgat gctaatggtg attttcccat gtttggaaaa     2580
gaaactgatt tatatacgta taatgccata aaagaacgtt atttaagtca taaaaaagat     2640
aaacgcaaat cattccaaga gcctttatac aaacccacaa aatcaggagg aattggacca     2700
cttataaaat ctattaaaat aatggataca agaaccattg ttaatcctgt taatcaaggt     2760
aaaggtgtcg tgtataatag taaaattgct cgtactgatg tattcaaaaa gggtgagaag     2820
tactatttaa ttcccattta cacaattgat cttatgaaaa atatcttacc tcaaaaagca     2880
attacagcag gaaaaggata tgaggattgg acaactattg atcctagctt tacttttttg     2940
tttagtcttt ttcccaatga tctaatccaa attgtcccct caaaaaacaa aacaattaaa     3000
gctagaacaa ctgtatcgaa aaaagaggta ttactaccct cactcacagg atattttaaa     3060
ggtgttcata gtggaactgc tgggattact gttgaaacac atgatggcag tattatagca     3120
aatgtaggct ccaagcagtt actatcattt gagaaatacc aggtagatgt acttggacat     3180
tacacaaaaa ttaagaagga aaaacgtatt ggaatggcaa tatag                     3225

<210>  48
<211>  3213
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 5 (Cas-Locus 5) ORF2, from Bacillus 
       species

<400>  48
atgaaattga aatatgtatt agggttggat attggaattg catcatgtgg ttgggcagta       60
ataaatcaag aaaaacatag aattgaagat ttaggggttc gtatttttga taaagctgag      120
aatcccaaag atggaaaatc tttagctaca cctagacgtg acgcacgttc taccagaaga      180
accctacgcc gtaaaaaaca tagaatgcaa cggataaaga tacttttagt aaagcacggc      240
ttactatcca agaccgaaat cgaccatcta tatgaaagtg ctactgagat cgatgtttgg      300
tacttacgtt taaatgctct agagcgcaga ttaaatccaa aagagtttgc tagagttctt      360
attcaccttg ctaaaagaag aggatttaaa tctaatagaa aagaaacaac tctctcggaa      420
aacggaaaaa tcttagaaaa tatttcagag aacctgcaga ttatggagca aaaaaattat      480
agaactgttg gagaaatgat tctaaaagat aaaaaatttg aaaatcataa aagaaacaaa      540
gatggtactt atatcgggac tgttactcgg caacaacttc aagaagaaat acaaatgata      600
ttcaatgcac aacgtttgta caaaaacaat catgcaacag agaaatttga aagtagctac      660
ttagaaatct gggcatctca acgtccctat gcttctaaag atcaaattga aaaaatgatt      720
ggttactgta ccttagagcc aaaagaaaaa agagtgccta aagcttcttg gtcatttcaa      780
tattttgtag cgctacaaac cataaacaac ctccgactga tcagtaaaga caggatagaa      840
gaactctctt ttgaagaaaa gaaacgaatt atgaatctag cactcgaaaa atcaattgtt      900
aaatacattg atatccgaaa attactatct gttcctaatg aatttcaatt taatagcctt      960
tcatattcag ctgatatagt agatacaacg gtggaaaata aaaaatgtat agaactcaaa     1020
gaatatcact ctattaacaa ggtatataaa caaatttacg aacagaacgc tctaaattta     1080
ttacctaaag attacgatac aattgcatac ggacttacta tctttaaaga tgataaagat     1140
atcctagaat atttacaaaa taaatacgta aatgcaaaag gaaaacctat aagtaatttt     1200
gctaacaaga cctacgatga tacatttatt caggtattat tgactctgaa tttctcaaaa     1260
atgggacatt tatcatttaa agctttaaaa aatattattc cttttttaga agaaggtcta     1320
tcctacgata aagcatgtga gaaggcagga tacaacttta agggaacatc ctacacaaaa     1380
aaaacaaagt acctacctgt tatccctcag aatacaaatc ctgttgtaca tcgtgctctt     1440
tcacaaacaa gaaaagttat aaatgccatt ataaaaaaat atggttctcc aaacgcaatc     1500
catattgaaa ctgcaagaga attatcgaaa acatttcaag aaagaaaaga aatagatagt     1560
atgtaccagg ataactctaa aaagaatgaa cacgccattc ataagttaaa agaattgggg     1620
aacattaacc cctcaggaat aaatattgtg aaatttaagc tttggaatga gcaagatagt     1680
agatgtatgt attctggaaa atatatcgaa ccacatcgat tatttgaaga aggttatacg     1740
gaagtagatc atatactccc ctatagccgg agcttagatg acagctataa caataaagtg     1800
ttaacgctag ggacagaaaa tcagggtaaa ggaaacagaa ctccttatga atacatgggg     1860
aatacttcaa tttgggatga atttgaaaca agagtacagt caaataaaaa aatcaacaaa     1920
aagaaacaac aaaaattact tttacaaaac ttttcacatg cgagagaaca agaatttatt     1980
gaacgcaatc tcaatgatac ccgttatgcc acaatatata tatcatccct tattcaacaa     2040
cacctcatat tctctgaaag ctctcgtgag aaaaaagttc atacagttag tggaattata     2100
acatctcatt tgcgtagtag atggggattt aacaaagatc ggaaagaggg gcatatccat     2160
catgctttag atgcggtaat cgttgctgtc acatccgatc acatgattca aagagtaaca     2220
aaatattata agttaaaaga attaaataga aaccgtcaag ccaaacggat gcagtttcct     2280
gaaccttggg aaggatttcg tttagagtta gaagcaagga tttctccaaa tacccagcaa     2340
tacttaaagg gaattcgttt aaaaaattac gccgatgtca atctatctga aatcaaacct     2400
atctttgttt caagaatgcc taagcgctct attactggtg aattacatca agaaacaatc     2460
cggaaattcc ttggttataa cgaaaaaggg aaagtgctaa ccgcaataaa aacaaaatta     2520
gaagatattc cttttgatgc taatggtgat tttcccatgt atggaaaaga aactgattta     2580
tatacgtata atgccataaa agaacgttat ttaagtcata aaaaagataa acgcaaatca     2640
ttccaagaac ctttatacaa acccacaaaa tcaggaggaa ttggaccact tataaaatct     2700
attaaaataa tggatacaag aaccattgtt aatcctgtta atcaaggtaa aggtgtcgtg     2760
tataatagta aaattgctcg cactgatgta ttcaaaaagg ctgaaaagta ctatttaatt     2820
cccatttaca caattgatct tatgaaaaat atcttacctc aaaaagcaat tacagcagga     2880
aaaggatatg aggattggac aaccattgat cctagcttta cttttttgtt tagtcttttt     2940
cccaatgatc taatccaaat tgtcccctca aaaaataaaa taattaaagc tagaacaact     3000
gtatcgaaaa aagaggtatt actaccctca ctcacaggat attttaaagg tgttcatagt     3060
ggaactgctg ggattactgt tgaaacacac gatggcagta ttatagcaaa tgtaggctcc     3120
aagcagttac tatcatttga gaaataccag gtagatgtac ttggacatta cacaaaaatt     3180
aagaaggaaa aacgtattgg aatggcaata tag                                  3213

<210>  49
<211>  3225
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 5 (Cas-Locus 5) ORF3, from Bacillus 
       species

<400>  49
atgaaggagg ttatgaaatt gaaatatgta ttagggttgg atattggaat tgcatcatgt       60
ggttgggcag taataaatca agaaaaacat agaattgaag atttaggggt tcgtattttt      120
gataaagctg agaatcccaa agatggaaaa tctttagcta cacctagacg tgacgcacgt      180
tctaccagaa gaaccctacg ccgtaaaaaa catagaatgc aacggataaa gatactttta      240
gtaaagcacg gcttactatc caagaccgaa atcgaccatc tatatgaaag tgctactgag      300
atcgatgttt ggtacttacg tttaaatgct ctagagcgca gattaaatcc aaaagagttt      360
gctagagttc ttattcacct tgctaaaaga agaggattta aatctaatag aaaagaaaca      420
actctctcgg aaaacggaaa aatcttagaa aatatttcag agaacctgca gattatggag      480
caaaaaaatt atagaactgt tggagaaatg attctaaaag ataaaaaatt tgaaaatcat      540
aaaagaaaca aagatggtac ttatatcggg actgttactc ggcaacaact tcaagaagaa      600
atacaaatga tattcaatgc acaacgtttg tacaaaaaca atcatgcaac agagaaattt      660
gaaagtagct acttagaaat ctgggcatct caacgtccct atgcttctaa agatcaaatt      720
gaaaaaatga ttggttactg taccttagag ccaaaagaaa aaagagtgcc taaagcttct      780
tggtcatttc aatattttgt agcgctacaa accataaaca acctccgact gatcagtaaa      840
gacaggatag aagaactctc ttttgaagaa aagaaacgaa ttatgaatct agcactcgaa      900
aaatcaattg ttaaatacat tgatatccga aaattactat ctgttcctaa tgaatttcaa      960
tttaatagcc tttcatattc agctgatata gtagatacaa cggtggaaaa taaaaaatgt     1020
atagaactca aagaatatca ctctattaac aaggtatata aacaaattta cgaacagaac     1080
gctctaaatt tattacctaa agattacgat acaattgcat acggacttac tatctttaaa     1140
gatgataaag atatcctaga atatttacaa aataaatacg taaatgcaaa aggaaaacct     1200
ataagtaatt ttgctaacaa gacctacgat gatacattta ttcaggtatt attgactctg     1260
aatttctcaa aaatgggaca tttatcattt aaagctttaa aaaatattat tcctttttta     1320
gaagaaggtc tatcctacga taaagcatgt gagaaggcag gatacaactt taagggaaca     1380
tcctacacaa aaaaaacaaa gtacctacct gttatccctc agaatacaaa tcctgttgta     1440
catcgtgctc tttcacaaac aagaaaagtt ataaatgcca ttataaaaaa atatggttct     1500
ccaaacgcaa tccatattga aactgcaaga gaattatcga aaacatttca agaaagaaaa     1560
gaaatagata gtatgtacca ggataactct aaaaagaatg aacacgccat tcataagtta     1620
aaagaattgg ggaacattaa cccctcagga ataaatattg tgaaatttaa gctttggaat     1680
gagcaagata gtagatgtat gtattctgga aaatatatcg aaccacatcg attatttgaa     1740
gaaggttata cggaagtaga tcatatactc ccctatagcc ggagcttaga tgacagctat     1800
aacaataaag tgttaacgct agggacagaa aatcagggta aaggaaacag aactccttat     1860
gaatacatgg ggaatacttc aatttgggat gaatttgaaa caagagtaca gtcaaataaa     1920
aaaatcaaca aaaagaaaca acaaaaatta cttttacaaa acttttcaca tgcgagagaa     1980
caagaattta ttgaacgcaa tctcaatgat acccgttatg ccacaatata tatatcatcc     2040
cttattcaac aacacctcat attctctgaa agctctcgtg agaaaaaagt tcatacagtt     2100
agtggaatta taacatctca tttgcgtagt agatggggat ttaacaaaga tcggaaagag     2160
gggcatatcc atcatgcttt agatgcggta atcgttgctg tcacatccga tcacatgatt     2220
caaagagtaa caaaatatta taagttaaaa gaattaaata gaaaccgtca agccaaacgg     2280
atgcagtttc ctgaaccttg ggaaggattt cgtttagagt tagaagcaag gatttctcca     2340
aatacccagc aatacttaaa gggaattcgt ttaaaaaatt acgccgatgt caatctatct     2400
gaaatcaaac ctatctttgt ttcaagaatg cctaagcgct ctattactgg tgaattacat     2460
caagaaacaa tccggaaatt ccttggttat aacgaaaaag ggaaagtgct aaccgcaata     2520
aaaacaaaat tagaagatat tccttttgat gctaatggtg attttcccat gtatggaaaa     2580
gaaactgatt tatatacgta taatgccata aaagaacgtt atttaagtca taaaaaagat     2640
aaacgcaaat cattccaaga acctttatac aaacccacaa aatcaggagg aattggacca     2700
cttataaaat ctattaaaat aatggataca agaaccattg ttaatcctgt taatcaaggt     2760
aaaggtgtcg tgtataatag taaaattgct cgcactgatg tattcaaaaa ggctgaaaag     2820
tactatttaa ttcccattta cacaattgat cttatgaaaa atatcttacc tcaaaaagca     2880
attacagcag gaaaaggata tgaggattgg acaaccattg atcctagctt tacttttttg     2940
tttagtcttt ttcccaatga tctaatccaa attgtcccct caaaaaataa aataattaaa     3000
gctagaacaa ctgtatcgaa aaaagaggta ttactaccct cactcacagg atattttaaa     3060
ggtgttcata gtggaactgc tgggattact gttgaaacac acgatggcag tattatagca     3120
aatgtaggct ccaagcagtt actatcattt gagaaatacc aggtagatgt acttggacat     3180
tacacaaaaa ttaagaagga aaaacgtatt ggaatggcaa tatag                     3225

<210>  50
<211>  1070
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 3 (Cas-Locus 3)  open reading frame 
       (ORF)-2 from Bacillus species

<400>  50
Met Lys Leu Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys 
1               5                   10                  15      
Gly Trp Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly 
            20                  25                  30          
Val Arg Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu 
        35                  40                  45              
Ala Thr Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg 
    50                  55                  60                  
Lys Lys His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly 
65                  70                  75                  80  
Leu Leu Ser Lys Thr Glu Ile Asp His Leu Tyr Glu Ser Ala Thr Glu 
                85                  90                  95      
Ile Asp Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu Arg Arg Leu Asn 
            100                 105                 110         
Pro Lys Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly 
        115                 120                 125             
Phe Lys Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile 
    130                 135                 140                 
Leu Glu Asn Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr 
145                 150                 155                 160 
Arg Thr Val Gly Glu Met Ile Leu Lys Asp Lys Arg Phe Glu Asn His 
                165                 170                 175     
Lys Arg Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln 
            180                 185                 190         
Leu Gln Glu Glu Ile Gln Met Ile Phe Asn Ala Gln Arg Leu Tyr Lys 
        195                 200                 205             
Asn Asn His Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp 
    210                 215                 220                 
Ala Ser Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile 
225                 230                 235                 240 
Gly Tyr Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser 
                245                 250                 255     
Trp Ser Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg 
            260                 265                 270         
Leu Ile Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys 
        275                 280                 285             
Arg Ile Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp 
    290                 295                 300                 
Ile Arg Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu 
305                 310                 315                 320 
Ser Tyr Ser Ala Asp Ile Val Asp Thr Thr Val Glu Asn Lys Lys Cys 
                325                 330                 335     
Ile Glu Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile 
            340                 345                 350         
Tyr Gly Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile 
        355                 360                 365             
Ala Tyr Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr 
    370                 375                 380                 
Leu Gln Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Leu 
385                 390                 395                 400 
Ala Asn Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu 
                405                 410                 415     
Asn Phe Ser Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile 
            420                 425                 430         
Ile Pro Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys 
        435                 440                 445             
Ala Gly Tyr Asn Phe Lys Gly Ala Ser Tyr Thr Lys Lys Thr Lys Tyr 
    450                 455                 460                 
Leu Pro Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu 
465                 470                 475                 480 
Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     
Pro Asn Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe 
            500                 505                 510         
Gln Glu Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys 
        515                 520                 525             
Asn Glu His Ala Ile Cys Lys Leu Lys Glu Leu Gly Asn Ile Lys Pro 
    530                 535                 540                 
Ser Gly Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly 
545                 550                 555                 560 
Arg Cys Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu 
                565                 570                 575     
Glu Gly Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu 
            580                 585                 590         
Asp Asp Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly Thr Glu Asn Gln 
        595                 600                 605             
Arg Lys Gly Asn Lys Thr Pro Tyr Glu Tyr Met Arg Asn Asn Ser Ile 
    610                 615                 620                 
Trp Asp Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys 
625                 630                 635                 640 
Lys Lys Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu 
                645                 650                 655     
Gln Glu Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile 
            660                 665                 670         
Tyr Leu Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser 
        675                 680                 685             
Arg Glu Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu 
    690                 695                 700                 
Arg Ser Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His 
705                 710                 715                 720 
His Ala Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile 
                725                 730                 735     
Gln Arg Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Ile 
            740                 745                 750         
Gln Ala Lys Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu 
        755                 760                 765             
Glu Leu Glu Ala Arg Val Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly 
    770                 775                 780                 
Ile Arg Phe Lys Asn Tyr Ala Asp Val Asp Leu Ser Glu Ile Lys Pro 
785                 790                 795                 800 
Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His 
                805                 810                 815     
Gln Glu Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val 
            820                 825                 830         
Leu Thr Ala Thr Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn 
        835                 840                 845             
Gly Asp Phe Pro Met Phe Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn 
    850                 855                 860                 
Ala Ile Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser 
865                 870                 875                 880 
Phe Gln Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro 
                885                 890                 895     
Leu Ile Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro 
            900                 905                 910         
Val Asn Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr 
        915                 920                 925             
Asp Val Phe Lys Lys Gly Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr 
    930                 935                 940                 
Ile Asp Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly 
945                 950                 955                 960 
Lys Gly Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu 
                965                 970                 975     
Phe Ser Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn 
            980                 985                 990         
Lys Thr Ile Lys Ala Arg Thr Thr  Val Ser Lys Lys Glu  Val Leu Leu 
        995                 1000                 1005             
Pro Ser  Leu Thr Gly Tyr Phe  Lys Gly Val His Ser  Gly Thr Ala 
    1010                 1015                 1020             
Gly Ile  Thr Val Glu Thr His  Asp Gly Ser Ile Ile  Ala Asn Val 
    1025                 1030                 1035             
Gly Ser  Lys Gln Leu Leu Ser  Phe Glu Lys Tyr Gln  Val Asp Val 
    1040                 1045                 1050             
Leu Gly  His Tyr Thr Lys Ile  Lys Lys Glu Lys Arg  Ile Gly Met 
    1055                 1060                 1065             
Ala Ile  
    1070 

<210>  51
<211>  1074
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 3 (Cas-Locus 3) ORF3, from Bacillus 
       species

<400>  51
Met Lys Glu Val Met Lys Leu Lys Tyr Val Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      
Ile Ala Ser Cys Gly Trp Ala Val Ile Asn Gln Glu Lys His Arg Ile 
            20                  25                  30          
Glu Asp Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp 
        35                  40                  45              
Gly Lys Ser Leu Ala Thr Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg 
    50                  55                  60                  
Thr Leu Arg Arg Lys Lys His Arg Met Gln Arg Ile Lys Ile Leu Leu 
65                  70                  75                  80  
Val Lys His Gly Leu Leu Ser Lys Thr Glu Ile Asp His Leu Tyr Glu 
                85                  90                  95      
Ser Ala Thr Glu Ile Asp Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu 
            100                 105                 110         
Arg Arg Leu Asn Pro Lys Glu Phe Ala Arg Val Leu Ile His Leu Ala 
        115                 120                 125             
Lys Arg Arg Gly Phe Lys Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu 
    130                 135                 140                 
Asn Gly Gln Ile Leu Glu Asn Ile Ser Glu Asn Leu Gln Ile Met Glu 
145                 150                 155                 160 
Gln Lys Asn Tyr Arg Thr Val Gly Glu Met Ile Leu Lys Asp Lys Arg 
                165                 170                 175     
Phe Glu Asn His Lys Arg Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val 
            180                 185                 190         
Thr Arg Gln Gln Leu Gln Glu Glu Ile Gln Met Ile Phe Asn Ala Gln 
        195                 200                 205             
Arg Leu Tyr Lys Asn Asn His Ala Thr Glu Lys Phe Glu Ser Ser Tyr 
    210                 215                 220                 
Leu Glu Ile Trp Ala Ser Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile 
225                 230                 235                 240 
Glu Lys Met Ile Gly Tyr Cys Thr Leu Glu Pro Lys Glu Lys Arg Val 
                245                 250                 255     
Pro Lys Ala Ser Trp Ser Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile 
            260                 265                 270         
Asn Asn Leu Arg Leu Ile Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe 
        275                 280                 285             
Glu Glu Lys Lys Arg Ile Met Asn Leu Ala Leu Glu Lys Ser Ile Val 
    290                 295                 300                 
Lys Tyr Ile Asp Ile Arg Lys Leu Leu Ser Val Pro Asn Glu Phe Gln 
305                 310                 315                 320 
Phe Asn Ser Leu Ser Tyr Ser Ala Asp Ile Val Asp Thr Thr Val Glu 
                325                 330                 335     
Asn Lys Lys Cys Ile Glu Leu Lys Glu Tyr His Ser Ile Asn Lys Val 
            340                 345                 350         
Tyr Lys Gln Ile Tyr Gly Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp 
        355                 360                 365             
Tyr Asp Thr Ile Ala Tyr Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp 
    370                 375                 380                 
Ile Leu Glu Tyr Leu Gln Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro 
385                 390                 395                 400 
Ile Ser Asn Leu Ala Asn Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val 
                405                 410                 415     
Leu Leu Thr Leu Asn Phe Ser Lys Met Gly His Leu Ser Phe Lys Ala 
            420                 425                 430         
Leu Lys Asn Ile Ile Pro Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys 
        435                 440                 445             
Ala Cys Glu Lys Ala Gly Tyr Asn Phe Lys Gly Ala Ser Tyr Thr Lys 
    450                 455                 460                 
Lys Thr Lys Tyr Leu Pro Val Ile Pro Gln Asn Thr Asn Pro Val Val 
465                 470                 475                 480 
His Arg Ala Leu Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile Lys 
                485                 490                 495     
Lys Tyr Gly Ser Pro Asn Ala Ile His Ile Glu Thr Ala Arg Glu Leu 
            500                 505                 510         
Ser Lys Thr Phe Gln Glu Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp 
        515                 520                 525             
Asn Ser Lys Lys Asn Glu His Ala Ile Cys Lys Leu Lys Glu Leu Gly 
    530                 535                 540                 
Asn Ile Lys Pro Ser Gly Ile Asn Ile Val Lys Phe Lys Leu Trp Asn 
545                 550                 555                 560 
Glu Gln Asp Gly Arg Cys Met Tyr Ser Gly Lys Tyr Ile Glu Pro His 
                565                 570                 575     
Arg Leu Phe Glu Glu Gly Tyr Thr Glu Val Asp His Ile Leu Pro Tyr 
            580                 585                 590         
Ser Arg Ser Leu Asp Asp Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly 
        595                 600                 605             
Thr Glu Asn Gln Arg Lys Gly Asn Lys Thr Pro Tyr Glu Tyr Met Arg 
    610                 615                 620                 
Asn Asn Ser Ile Trp Asp Glu Phe Glu Thr Arg Val Gln Ser Asn Lys 
625                 630                 635                 640 
Lys Ile Asn Lys Lys Lys Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser 
                645                 650                 655     
His Ala Arg Glu Gln Glu Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg 
            660                 665                 670         
Tyr Ala Thr Ile Tyr Leu Ser Ser Leu Ile Gln Gln His Leu Ile Phe 
        675                 680                 685             
Ser Glu Ser Ser Arg Glu Lys Lys Val His Thr Val Ser Gly Ile Ile 
    690                 695                 700                 
Thr Ser His Leu Arg Ser Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu 
705                 710                 715                 720 
Gly His Ile His His Ala Leu Asp Ala Val Ile Val Ala Val Thr Ser 
                725                 730                 735     
Asp His Met Ile Gln Arg Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu 
            740                 745                 750         
Asn Arg Asn Ile Gln Ala Lys Arg Met Gln Phe Pro Glu Pro Trp Glu 
        755                 760                 765             
Gly Phe Arg Leu Glu Leu Glu Ala Arg Val Ser Pro Asn Thr Gln Gln 
    770                 775                 780                 
Tyr Leu Lys Gly Ile Arg Phe Lys Asn Tyr Ala Asp Val Asp Leu Ser 
785                 790                 795                 800 
Glu Ile Lys Pro Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr 
                805                 810                 815     
Gly Glu Leu His Gln Glu Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu 
            820                 825                 830         
Lys Gly Lys Val Leu Thr Ala Thr Lys Thr Lys Leu Glu Asp Ile Pro 
        835                 840                 845             
Phe Asp Ala Asn Gly Asp Phe Pro Met Phe Gly Lys Glu Thr Asp Leu 
    850                 855                 860                 
Tyr Thr Tyr Asn Ala Ile Lys Glu Arg Tyr Leu Ser His Lys Lys Asp 
865                 870                 875                 880 
Lys Arg Lys Ser Phe Gln Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly 
                885                 890                 895     
Gly Ile Gly Pro Leu Ile Lys Ser Ile Lys Ile Met Asp Thr Arg Thr 
            900                 905                 910         
Ile Val Asn Pro Val Asn Gln Gly Lys Gly Val Val Tyr Asn Ser Lys 
        915                 920                 925             
Ile Ala Arg Thr Asp Val Phe Lys Lys Gly Glu Lys Tyr Tyr Leu Ile 
    930                 935                 940                 
Pro Ile Tyr Thr Ile Asp Leu Met Lys Asn Ile Leu Pro Gln Lys Ala 
945                 950                 955                 960 
Ile Thr Ala Gly Lys Gly Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser 
                965                 970                 975     
Phe Thr Phe Leu Phe Ser Leu Phe Pro Asn Asp Leu Ile Gln Ile Val 
            980                 985                 990         
Pro Ser Lys Asn Lys Thr Ile Lys  Ala Arg Thr Thr Val  Ser Lys Lys 
        995                 1000                 1005             
Glu Val  Leu Leu Pro Ser Leu  Thr Gly Tyr Phe Lys  Gly Val His 
    1010                 1015                 1020             
Ser Gly  Thr Ala Gly Ile Thr  Val Glu Thr His Asp  Gly Ser Ile 
    1025                 1030                 1035             
Ile Ala  Asn Val Gly Ser Lys  Gln Leu Leu Ser Phe  Glu Lys Tyr 
    1040                 1045                 1050             
Gln Val  Asp Val Leu Gly His  Tyr Thr Lys Ile Lys  Lys Glu Lys 
    1055                 1060                 1065             
Arg Ile  Gly Met Ala Ile 
    1070                 

<210>  52
<211>  1070
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 5 (Cas-Locus 5) ORF2, from Bacillus 
       species

<400>  52
Met Lys Leu Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys 
1               5                   10                  15      
Gly Trp Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly 
            20                  25                  30          
Val Arg Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu 
        35                  40                  45              
Ala Thr Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg 
    50                  55                  60                  
Lys Lys His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly 
65                  70                  75                  80  
Leu Leu Ser Lys Thr Glu Ile Asp His Leu Tyr Glu Ser Ala Thr Glu 
                85                  90                  95      
Ile Asp Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu Arg Arg Leu Asn 
            100                 105                 110         
Pro Lys Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly 
        115                 120                 125             
Phe Lys Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Lys Ile 
    130                 135                 140                 
Leu Glu Asn Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr 
145                 150                 155                 160 
Arg Thr Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His 
                165                 170                 175     
Lys Arg Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln 
            180                 185                 190         
Leu Gln Glu Glu Ile Gln Met Ile Phe Asn Ala Gln Arg Leu Tyr Lys 
        195                 200                 205             
Asn Asn His Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp 
    210                 215                 220                 
Ala Ser Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile 
225                 230                 235                 240 
Gly Tyr Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser 
                245                 250                 255     
Trp Ser Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg 
            260                 265                 270         
Leu Ile Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys 
        275                 280                 285             
Arg Ile Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp 
    290                 295                 300                 
Ile Arg Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu 
305                 310                 315                 320 
Ser Tyr Ser Ala Asp Ile Val Asp Thr Thr Val Glu Asn Lys Lys Cys 
                325                 330                 335     
Ile Glu Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile 
            340                 345                 350         
Tyr Glu Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile 
        355                 360                 365             
Ala Tyr Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr 
    370                 375                 380                 
Leu Gln Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Phe 
385                 390                 395                 400 
Ala Asn Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu 
                405                 410                 415     
Asn Phe Ser Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile 
            420                 425                 430         
Ile Pro Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys 
        435                 440                 445             
Ala Gly Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Lys Lys Thr Lys Tyr 
    450                 455                 460                 
Leu Pro Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu 
465                 470                 475                 480 
Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     
Pro Asn Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe 
            500                 505                 510         
Gln Glu Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys 
        515                 520                 525             
Asn Glu His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro 
    530                 535                 540                 
Ser Gly Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Ser 
545                 550                 555                 560 
Arg Cys Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu 
                565                 570                 575     
Glu Gly Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu 
            580                 585                 590         
Asp Asp Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly Thr Glu Asn Gln 
        595                 600                 605             
Gly Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile 
    610                 615                 620                 
Trp Asp Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys 
625                 630                 635                 640 
Lys Lys Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu 
                645                 650                 655     
Gln Glu Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile 
            660                 665                 670         
Tyr Ile Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser 
        675                 680                 685             
Arg Glu Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu 
    690                 695                 700                 
Arg Ser Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His 
705                 710                 715                 720 
His Ala Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile 
                725                 730                 735     
Gln Arg Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Arg 
            740                 745                 750         
Gln Ala Lys Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu 
        755                 760                 765             
Glu Leu Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly 
    770                 775                 780                 
Ile Arg Leu Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Pro 
785                 790                 795                 800 
Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His 
                805                 810                 815     
Gln Glu Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val 
            820                 825                 830         
Leu Thr Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn 
        835                 840                 845             
Gly Asp Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn 
    850                 855                 860                 
Ala Ile Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser 
865                 870                 875                 880 
Phe Gln Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro 
                885                 890                 895     
Leu Ile Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro 
            900                 905                 910         
Val Asn Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr 
        915                 920                 925             
Asp Val Phe Lys Lys Ala Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr 
    930                 935                 940                 
Ile Asp Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly 
945                 950                 955                 960 
Lys Gly Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu 
                965                 970                 975     
Phe Ser Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn 
            980                 985                 990         
Lys Ile Ile Lys Ala Arg Thr Thr  Val Ser Lys Lys Glu  Val Leu Leu 
        995                 1000                 1005             
Pro Ser  Leu Thr Gly Tyr Phe  Lys Gly Val His Ser  Gly Thr Ala 
    1010                 1015                 1020             
Gly Ile  Thr Val Glu Thr His  Asp Gly Ser Ile Ile  Ala Asn Val 
    1025                 1030                 1035             
Gly Ser  Lys Gln Leu Leu Ser  Phe Glu Lys Tyr Gln  Val Asp Val 
    1040                 1045                 1050             
Leu Gly  His Tyr Thr Lys Ile  Lys Lys Glu Lys Arg  Ile Gly Met 
    1055                 1060                 1065             
Ala Ile  
    1070 

<210>  53
<211>  1074
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9 endonuclease of Locus 5 (Cas-Locus 5) ORF3, from Bacillus 
       species

<400>  53
Met Lys Glu Val Met Lys Leu Lys Tyr Val Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      
Ile Ala Ser Cys Gly Trp Ala Val Ile Asn Gln Glu Lys His Arg Ile 
            20                  25                  30          
Glu Asp Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp 
        35                  40                  45              
Gly Lys Ser Leu Ala Thr Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg 
    50                  55                  60                  
Thr Leu Arg Arg Lys Lys His Arg Met Gln Arg Ile Lys Ile Leu Leu 
65                  70                  75                  80  
Val Lys His Gly Leu Leu Ser Lys Thr Glu Ile Asp His Leu Tyr Glu 
                85                  90                  95      
Ser Ala Thr Glu Ile Asp Val Trp Tyr Leu Arg Leu Asn Ala Leu Glu 
            100                 105                 110         
Arg Arg Leu Asn Pro Lys Glu Phe Ala Arg Val Leu Ile His Leu Ala 
        115                 120                 125             
Lys Arg Arg Gly Phe Lys Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu 
    130                 135                 140                 
Asn Gly Lys Ile Leu Glu Asn Ile Ser Glu Asn Leu Gln Ile Met Glu 
145                 150                 155                 160 
Gln Lys Asn Tyr Arg Thr Val Gly Glu Met Ile Leu Lys Asp Lys Lys 
                165                 170                 175     
Phe Glu Asn His Lys Arg Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val 
            180                 185                 190         
Thr Arg Gln Gln Leu Gln Glu Glu Ile Gln Met Ile Phe Asn Ala Gln 
        195                 200                 205             
Arg Leu Tyr Lys Asn Asn His Ala Thr Glu Lys Phe Glu Ser Ser Tyr 
    210                 215                 220                 
Leu Glu Ile Trp Ala Ser Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile 
225                 230                 235                 240 
Glu Lys Met Ile Gly Tyr Cys Thr Leu Glu Pro Lys Glu Lys Arg Val 
                245                 250                 255     
Pro Lys Ala Ser Trp Ser Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile 
            260                 265                 270         
Asn Asn Leu Arg Leu Ile Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe 
        275                 280                 285             
Glu Glu Lys Lys Arg Ile Met Asn Leu Ala Leu Glu Lys Ser Ile Val 
    290                 295                 300                 
Lys Tyr Ile Asp Ile Arg Lys Leu Leu Ser Val Pro Asn Glu Phe Gln 
305                 310                 315                 320 
Phe Asn Ser Leu Ser Tyr Ser Ala Asp Ile Val Asp Thr Thr Val Glu 
                325                 330                 335     
Asn Lys Lys Cys Ile Glu Leu Lys Glu Tyr His Ser Ile Asn Lys Val 
            340                 345                 350         
Tyr Lys Gln Ile Tyr Glu Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp 
        355                 360                 365             
Tyr Asp Thr Ile Ala Tyr Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp 
    370                 375                 380                 
Ile Leu Glu Tyr Leu Gln Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro 
385                 390                 395                 400 
Ile Ser Asn Phe Ala Asn Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val 
                405                 410                 415     
Leu Leu Thr Leu Asn Phe Ser Lys Met Gly His Leu Ser Phe Lys Ala 
            420                 425                 430         
Leu Lys Asn Ile Ile Pro Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys 
        435                 440                 445             
Ala Cys Glu Lys Ala Gly Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Lys 
    450                 455                 460                 
Lys Thr Lys Tyr Leu Pro Val Ile Pro Gln Asn Thr Asn Pro Val Val 
465                 470                 475                 480 
His Arg Ala Leu Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile Lys 
                485                 490                 495     
Lys Tyr Gly Ser Pro Asn Ala Ile His Ile Glu Thr Ala Arg Glu Leu 
            500                 505                 510         
Ser Lys Thr Phe Gln Glu Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp 
        515                 520                 525             
Asn Ser Lys Lys Asn Glu His Ala Ile His Lys Leu Lys Glu Leu Gly 
    530                 535                 540                 
Asn Ile Asn Pro Ser Gly Ile Asn Ile Val Lys Phe Lys Leu Trp Asn 
545                 550                 555                 560 
Glu Gln Asp Ser Arg Cys Met Tyr Ser Gly Lys Tyr Ile Glu Pro His 
                565                 570                 575     
Arg Leu Phe Glu Glu Gly Tyr Thr Glu Val Asp His Ile Leu Pro Tyr 
            580                 585                 590         
Ser Arg Ser Leu Asp Asp Ser Tyr Asn Asn Lys Val Leu Thr Leu Gly 
        595                 600                 605             
Thr Glu Asn Gln Gly Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly 
    610                 615                 620                 
Asn Thr Ser Ile Trp Asp Glu Phe Glu Thr Arg Val Gln Ser Asn Lys 
625                 630                 635                 640 
Lys Ile Asn Lys Lys Lys Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser 
                645                 650                 655     
His Ala Arg Glu Gln Glu Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg 
            660                 665                 670         
Tyr Ala Thr Ile Tyr Ile Ser Ser Leu Ile Gln Gln His Leu Ile Phe 
        675                 680                 685             
Ser Glu Ser Ser Arg Glu Lys Lys Val His Thr Val Ser Gly Ile Ile 
    690                 695                 700                 
Thr Ser His Leu Arg Ser Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu 
705                 710                 715                 720 
Gly His Ile His His Ala Leu Asp Ala Val Ile Val Ala Val Thr Ser 
                725                 730                 735     
Asp His Met Ile Gln Arg Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu 
            740                 745                 750         
Asn Arg Asn Arg Gln Ala Lys Arg Met Gln Phe Pro Glu Pro Trp Glu 
        755                 760                 765             
Gly Phe Arg Leu Glu Leu Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln 
    770                 775                 780                 
Tyr Leu Lys Gly Ile Arg Leu Lys Asn Tyr Ala Asp Val Asn Leu Ser 
785                 790                 795                 800 
Glu Ile Lys Pro Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr 
                805                 810                 815     
Gly Glu Leu His Gln Glu Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu 
            820                 825                 830         
Lys Gly Lys Val Leu Thr Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro 
        835                 840                 845             
Phe Asp Ala Asn Gly Asp Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu 
    850                 855                 860                 
Tyr Thr Tyr Asn Ala Ile Lys Glu Arg Tyr Leu Ser His Lys Lys Asp 
865                 870                 875                 880 
Lys Arg Lys Ser Phe Gln Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly 
                885                 890                 895     
Gly Ile Gly Pro Leu Ile Lys Ser Ile Lys Ile Met Asp Thr Arg Thr 
            900                 905                 910         
Ile Val Asn Pro Val Asn Gln Gly Lys Gly Val Val Tyr Asn Ser Lys 
        915                 920                 925             
Ile Ala Arg Thr Asp Val Phe Lys Lys Ala Glu Lys Tyr Tyr Leu Ile 
    930                 935                 940                 
Pro Ile Tyr Thr Ile Asp Leu Met Lys Asn Ile Leu Pro Gln Lys Ala 
945                 950                 955                 960 
Ile Thr Ala Gly Lys Gly Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser 
                965                 970                 975     
Phe Thr Phe Leu Phe Ser Leu Phe Pro Asn Asp Leu Ile Gln Ile Val 
            980                 985                 990         
Pro Ser Lys Asn Lys Ile Ile Lys  Ala Arg Thr Thr Val  Ser Lys Lys 
        995                 1000                 1005             
Glu Val  Leu Leu Pro Ser Leu  Thr Gly Tyr Phe Lys  Gly Val His 
    1010                 1015                 1020             
Ser Gly  Thr Ala Gly Ile Thr  Val Glu Thr His Asp  Gly Ser Ile 
    1025                 1030                 1035             
Ile Ala  Asn Val Gly Ser Lys  Gln Leu Leu Ser Phe  Glu Lys Tyr 
    1040                 1045                 1050             
Gln Val  Asp Val Leu Gly His  Tyr Thr Lys Ile Lys  Lys Glu Lys 
    1055                 1060                 1065             
Arg Ile  Gly Met Ala Ile 
    1070                 

<210>  54
<211>  189
<212>  DNA
<213>  Solanum tuberosum

<400>  54
gtaagtttct gcttctacct ttgatatata tataataatt atcattaatt agtagtaata       60
taatatttca aatatttttt tcaaaataaa agaatgtagt atatagcaat tgcttttctg      120
tagtttataa gtgtgtatat tttaatttat aacttttcta atatatgacc aaaacatggt      180
gatgtgcag                                                              189

<210>  55
<211>  9
<212>  PRT
<213>  Simian virus

<400>  55
Met Ala Pro Lys Lys Lys Arg Lys Val 
1               5                   

<210>  56
<211>  18
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  56
Lys Arg Pro Arg Asp Arg His Asp Gly Glu Leu Gly Gly Arg Lys Arg 
1               5                   10                  15      
Ala Arg 
        

<210>  57
<211>  1101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Maize Optimized Cas-Locus 3 Endonuclease with N- and C-terminal 
       NLSs

<400>  57
Met Ala Pro Lys Lys Lys Arg Lys Val Met Lys Glu Val Met Lys Leu 
1               5                   10                  15      
Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp Ala 
            20                  25                  30          
Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly Val Arg Ile 
        35                  40                  45              
Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Thr Pro 
    50                  55                  60                  
Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys His 
65                  70                  75                  80  
Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly Leu Leu Ser 
                85                  90                  95      
Lys Thr Glu Ile Asp His Leu Tyr Glu Ser Ala Thr Glu Ile Asp Val 
            100                 105                 110         
Trp Tyr Leu Arg Leu Asn Ala Leu Glu Arg Arg Leu Asn Pro Lys Glu 
        115                 120                 125             
Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys Ser 
    130                 135                 140                 
Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu Asn 
145                 150                 155                 160 
Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr Arg Thr Val 
                165                 170                 175     
Gly Glu Met Ile Leu Lys Asp Lys Arg Phe Glu Asn His Lys Arg Asn 
            180                 185                 190         
Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln Glu 
        195                 200                 205             
Glu Ile Gln Met Ile Phe Asn Ala Gln Arg Leu Tyr Lys Asn Asn His 
    210                 215                 220                 
Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser Gln 
225                 230                 235                 240 
Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr Cys 
                245                 250                 255     
Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser Phe 
            260                 265                 270         
Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile Ser 
        275                 280                 285             
Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Arg Ile Met 
    290                 295                 300                 
Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg Lys 
305                 310                 315                 320 
Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr Ser 
                325                 330                 335     
Ala Asp Ile Val Asp Thr Thr Val Glu Asn Lys Lys Cys Ile Glu Leu 
            340                 345                 350         
Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly Gln 
        355                 360                 365             
Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile Ala Tyr Gly 
    370                 375                 380                 
Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln Asn 
385                 390                 395                 400 
Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Leu Ala Asn Lys 
                405                 410                 415     
Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu Asn Phe Ser 
            420                 425                 430         
Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro Phe 
        435                 440                 445             
Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly Tyr 
    450                 455                 460                 
Asn Phe Lys Gly Ala Ser Tyr Thr Lys Lys Thr Lys Tyr Leu Pro Val 
465                 470                 475                 480 
Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln Thr 
                485                 490                 495     
Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn Ala 
            500                 505                 510         
Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu Arg 
        515                 520                 525             
Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu His 
    530                 535                 540                 
Ala Ile Cys Lys Leu Lys Glu Leu Gly Asn Ile Lys Pro Ser Gly Ile 
545                 550                 555                 560 
Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly Arg Cys Met 
                565                 570                 575     
Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly Tyr 
            580                 585                 590         
Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp Ser 
        595                 600                 605             
Tyr Asn Asn Lys Val Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys Gly 
    610                 615                 620                 
Asn Lys Thr Pro Tyr Glu Tyr Met Arg Asn Asn Ser Ile Trp Asp Glu 
625                 630                 635                 640 
Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys Gln 
                645                 650                 655     
Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu Gln Glu Phe 
            660                 665                 670         
Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu Ser 
        675                 680                 685             
Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Glu Lys 
    690                 695                 700                 
Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser Arg 
705                 710                 715                 720 
Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala Leu 
                725                 730                 735     
Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg Val 
            740                 745                 750         
Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Ile Gln Ala Lys 
        755                 760                 765             
Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu Glu 
    770                 775                 780                 
Ala Arg Val Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile Arg Phe 
785                 790                 795                 800 
Lys Asn Tyr Ala Asp Val Asp Leu Ser Glu Ile Lys Pro Ile Phe Val 
                805                 810                 815     
Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu Thr 
            820                 825                 830         
Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr Ala 
        835                 840                 845             
Thr Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp Phe 
    850                 855                 860                 
Pro Met Phe Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile Lys 
865                 870                 875                 880 
Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln Glu 
                885                 890                 895     
Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile Lys 
            900                 905                 910         
Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn Gln 
        915                 920                 925             
Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val Phe 
    930                 935                 940                 
Lys Lys Gly Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp Leu 
945                 950                 955                 960 
Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly Tyr 
                965                 970                 975     
Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser Leu 
            980                 985                 990         
Phe Pro Asn Asp Leu Ile Gln Ile  Val Pro Ser Lys Asn  Lys Thr Ile 
        995                 1000                 1005             
Lys Ala  Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
    1010                 1015                 1020             
Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1025                 1030                 1035             
Thr Val  Glu Thr His Asp Gly  Ser Ile Ile Ala Asn  Val Gly Ser 
    1040                 1045                 1050             
Lys Gln  Leu Leu Ser Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1055                 1060                 1065             
His Tyr  Thr Lys Ile Lys Lys  Glu Lys Arg Ile Gly  Met Ala Ile 
    1070                 1075                 1080             
Lys Arg  Pro Arg Asp Arg His  Asp Gly Glu Leu Gly  Gly Arg Lys 
    1085                 1090                 1095             
Arg Ala  Arg 
    1100     

<210>  58
<211>  896
<212>  DNA
<213>  Zea mays

<400>  58
gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta       60
taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      120
atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      180
gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt      240
ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg      300
caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta      360
gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct      420
ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa      480
tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta      540
aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt      600
ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca      660
cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg      720
ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag      780
gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc      840
ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctt          896

<210>  59
<211>  82
<212>  DNA
<213>  Zea mays

<400>  59
tccccaacct cgtgttgttc ggagcgcaca cacacacaac cagatctccc ccaaatccac       60
ccgtcggcac ctccgcttca ag                                                82

<210>  60
<211>  1013
<212>  DNA
<213>  Zea mays

<400>  60
gtacgccgct cgtcctcccc cccccccctc tctaccttct ctagatcggc gttccggtcc       60
atgcatggtt agggcccggt agttctactt ctgttcatgt ttgtgttaga tccgtgtttg      120
tgttagatcc gtgctgctag cgttcgtaca cggatgcgac ctgtacgtca gacacgttct      180
gattgctaac ttgccagtgt ttctctttgg ggaatcctgg gatggctcta gccgttccgc      240
agacgggatc gatttcatga ttttttttgt ttcgttgcat agggtttggt ttgccctttt      300
cctttatttc aatatatgcc gtgcacttgt ttgtcgggtc atcttttcat gctttttttt      360
gtcttggttg tgatgatgtg gtctggttgg gcggtcgttc tagatcggag tagaattctg      420
tttcaaacta cctggtggat ttattaattt tggatctgta tgtgtgtgcc atacatattc      480
atagttacga attgaagatg atggatggaa atatcgatct aggataggta tacatgttga      540
tgcgggtttt actgatgcat atacagagat gctttttgtt cgcttggttg tgatgatgtg      600
gtgtggttgg gcggtcgttc attcgttcta gatcggagta gaatactgtt tcaaactacc      660
tggtgtattt attaattttg gaactgtatg tgtgtgtcat acatcttcat agttacgagt      720
ttaagatgga tggaaatatc gatctaggat aggtatacat gttgatgtgg gttttactga      780
tgcatataca tgatggcata tgcagcatct attcatatgc tctaaccttg agtacctatc      840
tattataata aacaagtatg ttttataatt attttgatct tgatatactt ggatgatggc      900
atatgcagca gctatatgtg gattttttta gccctgcctt catacgctat ttatttgctt      960
ggtactgttt cttttgtcga tgctcaccct gttgtttggt gttacttctg cag            1013

<210>  61
<211>  5829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maize Optimized Cas-Locus 3 Expression Cassette, synthesized

<400>  61
gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta       60
taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      120
atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      180
gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt      240
ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg      300
caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta      360
gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct      420
ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa      480
tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta      540
aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt      600
ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca      660
cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg      720
ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag      780
gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc      840
ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctttccc      900
caacctcgtg ttgttcggag cgcacacaca cacaaccaga tctcccccaa atccacccgt      960
cggcacctcc gcttcaaggt acgccgctcg tcctcccccc cccccctctc taccttctct     1020
agatcggcgt tccggtccat gcatggttag ggcccggtag ttctacttct gttcatgttt     1080
gtgttagatc cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct     1140
gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg aatcctggga     1200
tggctctagc cgttccgcag acgggatcga tttcatgatt ttttttgttt cgttgcatag     1260
ggtttggttt gcccttttcc tttatttcaa tatatgccgt gcacttgttt gtcgggtcat     1320
cttttcatgc ttttttttgt cttggttgtg atgatgtggt ctggttgggc ggtcgttcta     1380
gatcggagta gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg     1440
tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat atcgatctag     1500
gataggtata catgttgatg cgggttttac tgatgcatat acagagatgc tttttgttcg     1560
cttggttgtg atgatgtggt gtggttgggc ggtcgttcat tcgttctaga tcggagtaga     1620
atactgtttc aaactacctg gtgtatttat taattttgga actgtatgtg tgtgtcatac     1680
atcttcatag ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt     1740
tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat tcatatgctc     1800
taaccttgag tacctatcta ttataataaa caagtatgtt ttataattat tttgatcttg     1860
atatacttgg atgatggcat atgcagcagc tatatgtgga tttttttagc cctgccttca     1920
tacgctattt atttgcttgg tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt     1980
tacttctgca ggtcgactct agaggatcca tggcaccgaa gaagaagcgc aaggtgatga     2040
aggaggtcat gaaactcaag tatgtcctcg gcttggacat cggcatcgcc agctgcggct     2100
gggccgtaat aaatcaagag aagcaccgca tcgaggacct cggcgtcaga atcttcgaca     2160
aagccgagaa ccccaaggta agtttctgct tctacctttg atatatatat aataattatc     2220
attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga atgtagtata     2280
tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac ttttctaata     2340
tatgaccaaa acatggtgat gtgcaggacg gcaaaagcct cgcgaccccg aggagagacg     2400
cgcgctccac gaggaggaca ctgaggcgca agaagcacag gatgcagaga atcaagatcc     2460
tcctcgtcaa acacgggctc ctctccaaga cagagatcga ccacctctat gaaagtgcca     2520
cagagatcga cgtgtggtac ctcagactca acgccctcga gcgcagatta aatcccaagg     2580
agttcgccag ggtcctcatc cacctggcca aacggcgggg cttcaagagc aacagaaagg     2640
agaccacgct gtccgagaac ggccagatcc tcgaaaatat ttccgagaac cttcagatca     2700
tggagcagaa aaactaccgc accgtcggcg agatgatcct caaggataaa agattcgaga     2760
accataaaag aaacaaggac ggcacgtaca ttggcacagt gaccagacag cagctgcagg     2820
aggaaataca aatgatcttc aacgcccagc gcctctacaa gaacaaccac gccacagaga     2880
agttcgagag cagctatctg gagatatggg ccagccagag accatacgcc agcaaggacc     2940
agatcgagaa gatgatcggc tactgcaccc tcgagcccaa agagaagagg gtcccaaagg     3000
cgtcgtggag ctttcagtat tttgtcgcgc tgcagaccat aaacaacctc agactgatct     3060
cgaaggacag gatcgaggag ctcagcttcg aggagaaaaa gcggatcatg aacctcgccc     3120
ttgagaaatc aattgtcaaa tacattgaca tccgcaagct cctcagcgtg cccaacgagt     3180
ttcagttcaa cagcctcagc tacagcgccg acatcgtcga caccaccgtc gaaaataaaa     3240
aatgcatcga gctcaaggag taccacagca tcaacaaggt atataaacag atctacggcc     3300
agaacgccct caaccttctt cccaaggact acgacacaat cgcctacggc ctcaccatat     3360
tcaaggacga caaggacatc ctcgagtacc tccaaaataa atacgtcaac gccaagggca     3420
agccaatctc caaccttgcc aacaagacat acgacgatac atttatccag gtcctcctca     3480
cactcaactt tagcaagatg ggccacctct ccttcaaagc cctcaaaaat attatcccct     3540
tcctcgagga gggcctcagc tacgacaaag catgtgagaa ggccggctac aacttcaagg     3600
gcgccagcta caccaagaaa acaaagtacc tgcccgtgat cccccagaat acaaaccccg     3660
tcgtccacag agccctcagc cagacgcgga aggtcatcaa cgccatcata aaaaaatatg     3720
gctcgccaaa tgcgatccac atcgagaccg ctagggagct tagcaagacc ttccaggagc     3780
gcaaggagat cgacagcatg taccaggaca acagcaagaa gaacgagcac gccatctgca     3840
agctcaagga gctcggcaac attaaaccca gcggaataaa tatcgtcaag ttcaagctct     3900
ggaacgagca ggacggcaga tgtatgtaca gcggaaaata tatagagccg cacaggctct     3960
tcgaggaggg ctacacagag gtcgaccaca tactgccgta cagcaggagc cttgacgact     4020
cgtacaacaa taaagtcctc acgcttggca cagagaacca gcgcaagggc aacaaaacgc     4080
cctacgaata catgaggaat aatagcatct gggacgagtt cgagacaagg gtgcagtcca     4140
ataaaaaaat caacaagaag aagcagcaga agctcctcct ccagaacttc agccacgcca     4200
gggagcagga gttcattgag agaaacctca acgacacgcg ctacgccacc atctacctca     4260
gcagcctgat tcagcagcac ctgattttca gcgagagcag cagggagaag aaggtccaca     4320
cagtctcggg gatcatcaca tcccacctgc gctcccgctg gggcttcaac aaggaccgca     4380
aggagggcca catccaccac gccctcgacg ccgtcatcgt cgccgtcacc agcgaccaca     4440
tgatccagcg cgtcacaaaa tattacaagc tcaaggagct caacaggaac atccaggcca     4500
agcgcatgca gtttccggag ccttgggagg gcttcaggct cgagctcgag gcccgcgtca     4560
gcccgaacac ccagcagtac ctcaagggca tcaggtttaa gaactacgcc gacgtggacc     4620
ttagcgaaat caaacccatc ttcgtctcaa gaatgcccaa gcggtccatc acgggcgagc     4680
tccaccagga gacaatccgc aagttcctcg gctacaacga gaaagggaaa gtcctgacgg     4740
ccaccaagac caagctcgag gacatcccct tcgacgccaa tggcgacttt cccatgttcg     4800
gcaaggagac cgacctctac acctacaacg ccataaaaga gcgctacctc agccataaaa     4860
aagacaaacg caagtccttc caggagccgc tctacaaacc caccaagagc gggggcatcg     4920
gccccctcat aaaaagcatt aaaataatgg acacccgcac catcgtcaac cccgtcaatc     4980
aaggcaaggg cgtcgtctac aacagcaaga tagcccgcac cgacgtgttc aagaaaggcg     5040
agaagtacta cctgatcccg atctacacta tagacctgat gaaaaatatc ctcccacaga     5100
aggccataac ggcgggcaaa ggctacgagg actggacgac catagaccct tccttcacat     5160
tcctcttctc cctgttcccc aacgacctca tccagatcgt ccccagcaag aacaagacaa     5220
ttaaagccag aacgacggtg tccaagaagg aggtcctcct cccctccctg accggctact     5280
ttaagggcgt gcacagcggc acagccggca tcacggtgga gacccacgac ggctccatca     5340
ttgctaacgt cggcagcaaa cagctgctca gcttcgagaa gtaccaggtc gacgtcctcg     5400
gccactatac caaaattaag aaggagaagc gcatcggcat ggccataaag aggcccaggg     5460
accgccacga cggcgagctc ggcggcagga agagggcccg ctagttaacc tagacttgtc     5520
catcttctgg attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac     5580
atgctaatca ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct     5640
gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta     5700
taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa     5760
tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg     5820
aatgcggcc                                                             5829

<210>  62
<211>  16
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA Repeat Region for Cas-Locus 3 Version 2 from Bacillus 
       species

<400>  62
gcuauaguuc cauaag                                                       16

<210>  63
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>   sgRNA Repeat Region for Cas-Locus 3 Version 3 from Bacillus 
       species

<400>  63
gcuauaguuc cauaagaaac aucgcu                                            26

<210>  64
<211>  16
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA Anti-Repeat Region for Cas-Locus 3 Version 2 from Bacillus 
       species

<400>  64
cuuaaguuac uauagu                                                       16

<210>  65
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA Anti-Repeat Region for Cas-Locus 3 Version 3 Bacillus 
       species

<400>  65
agcgauguuu cuuaaguuac uauagu                                            26

<210>  66
<211>  157
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthesized sgRNA for Cas-Locus 3 Version 2

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  66
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaaggaaa cuuaaguuac uauaguaagg       60
gcaaugaccc guggcguuug gggaucgccu uauccuggua uggauauucu ccccauguga      120
aaagcaccua agcauagcgc uauggugcuu uuauuuu                               157

<210>  67
<211>  177
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthesized sgRNA for Cas-Locus 3 Version 3

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  67
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaagaaac aucgcugaaa agcgauguuu       60
cuuaaguuac uauaguaagg gcaaugaccc guggcguuug gggaucgccu uauccuggua      120
uggauauucu ccccauguga aaagcaccua agcauagcgc uauggugcuu uuauuuu         177

<210>  68
<211>  1000
<212>  DNA
<213>  Zea mays

<400>  68
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60
tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120
ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180
gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240
ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300
atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360
gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420
gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480
aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540
cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600
aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660
attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720
ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780
agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840
agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900
ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960
gtggagcgta ccttataaac cgagccgcaa gcaccgaatt                           1000

<210>  69
<211>  29
<212>  DNA
<213>  Zea mays

<400>  69
ggtcagggac accatatgaa tgaaagaaa                                         29

<210>  70
<211>  30
<212>  DNA
<213>  Zea mays

<400>  70
gatcccacat aggtgatgag ctaagagtaa                                        30

<210>  71
<211>  30
<212>  DNA
<213>  Zea mays

<400>  71
gaccacacga atctggcctt gaccaggata                                        30

<210>  72
<211>  6065
<212>  DNA
<213>  Unknown

<220>
<223>  Locus 42 from Bacillus species

<400>  72
ccttaaaaag atacgatacg tactacgcag acactaacca gaacaagggt taaaaaacta       60
cacttgatat ataaatttta tatacctaca ggtttttgag gtaagttgga gttgttaaga      120
tgaagaaaaa caaggagtca tattttatac acgaatatac cttgcgagac aagactacta      180
aatcaataaa aattgaatcg tggcgttcat taaaggaaga aatgcaagtc ctgctcataa      240
aagacagtgc catctttcaa attcaaatgc taaaagtaga ttcaaaaaag agtaacatag      300
cgctatgcca tgctactctt ttttatttta ataatatagc gtgatttttc tacacttaaa      360
tgcaactagt tccgcaaaca aaaaataaat tactatttca aaaaacaaga aaccttaagg      420
attaaactga cgaaagatgc tcttttttga taaggaaaat ccttatctaa ggctataata      480
ataaggtttt taaagcatcc atcatagaat agcgatgttt cttttggaac tatagccaca      540
acacacttat caatatctat tccgatacca tagcatagcg atttttctta gggaactata      600
gctaaatcgt tcgttccacc tgcaatacgt gcatcatggc attacaatat ttcttatgga      660
actatagcca taatcaacgc cctctaaatg tcgactatat catagcgatg tttctttcag      720
aactatagcc caaattccaa aacaaaataa aatagttgca tcatatcata gcgattttcc      780
ttatggaact atagctgtgt agacaatgat aatgcaggta gagccatcat agcatagcgg      840
ttttcctttt ggaactatag cctcttcaaa cgcccaaatt acttttttgg aatcatagca      900
tagcaatgtt tcttagggaa ttatagttat ccatatgcca taacttgata gggttcaatc      960
atagcatagc gatgtttctc atggaacttt agcttgtatt tacttattga atcaataatg     1020
tttaccatag catattaata tttcttatgg aactatagcc acttcttcag gcgtctgatt     1080
cgtcgcctcg atcatagcat agcaatattt cttatggaac tatagcatgt cttgatacat     1140
aaaggaattt acaaagatca tagcataacg atttttcttt tcgaactata gctgatagcc     1200
tcgtttggca gccagaccaa gaatcatagt ggtgtcaatg tcaagtgtga caagtttaaa     1260
atcatagcat agcttttttc tcctagaatt atagctcaga tggcttatcc ctttcagaat     1320
tctttatcaa atcatagcat agcgattttt cttttggaac tatagcgact tgggatgatt     1380
tgtcttattc ttggaatcat agcttagcga tggttcttag gaaactatag ctcgtttctt     1440
ctaagtaaat aaggaggaat gatcataaca tagcgatatt ctccacggaa tgatagcatt     1500
aatattaaca agttaagaaa tgttcctctt aattaattta tatcacaatt attcccaatt     1560
tcattatttt tataattata cgtttatcta ggtataaagt ttatttttcg ggtcaataat     1620
taaatcataa ggatcatatc atagcgatgt ttcttaagtt actatagtaa gggcaatgac     1680
ccgtggcgtt tggggatcgc cttatcctgg tttggatatt ctccccatgt taaaagcacc     1740
taagcatagc gctatggtgc ttttattatg taaaacatga aggaggttat aaaattgaaa     1800
tatgtattag ggttggatat tggaatcgca tcctgtggtt gggcagtaat aaatcaagaa     1860
aaacatagaa tagaagattt aggggttcgt atttttgata aagctgaaaa ccccaaagat     1920
ggaaaatctt tagctacacc tagacgtgac gcacgctcta ccaggagaat cctacgccgt     1980
aaaaaacata gaatgcaacg gataaagata cttttagtaa agcatggctt actatccaag     2040
accgaactcg accatctata tgaaagtgct actgagaaca atgtttggga cttacgttta     2100
aatgctctag atcacagatt aaatccaaaa gagtttgcca gagttcttat tcaccttgct     2160
aaaagaagag gatttaaatc taatagaaaa gaaacaactc tttcggaaaa cggacaaatc     2220
ttagaaaaca tttcagagaa cctgcagatt atggagcaaa aaaattatag aactgttgga     2280
gaaatgattc taaaagataa aaaatttgaa aaccataaaa gaaacaaaga tggtacttat     2340
atcgggactg ttactcggca acaacttcaa gaagaaatac aaatgatatt ccatgcacaa     2400
cgtttgtaca aaaatgatca tgcaacagag aaatttgaaa gtagctactt agaaatctgg     2460
gcatctcaac gtccctatgc ttctaaagat caaattgaaa aaatgattgg ctactgtacc     2520
ttagagccaa aagaaaaaag agtgcctaaa gcttcttggt catttcaata ttttgtagcg     2580
ctacaaacca taaacaacct ccgactgatc agtaaagaca gaatagaaga actctccttt     2640
gaagaaaaga aacgaattat gaatttagca ctcgaaaaat caattgttaa atacattgat     2700
atccgaaaat tattatctgt tcctaatgaa tttcaattta atagcctatc atattcagct     2760
gatacagtag atacaacggt ggaaagtaga aaatgtatag aactcaaaga atatcattct     2820
attaacaagg tatataaaca aatttacgga cagaacgccc taaatttatt acctaaagat     2880
tacgatacaa ttgcatacgg acttactatc tttaaagatg ataaagatat cctagcatat     2940
ttacaaaata aatacgtaaa tgcaaaagga aaatctataa gtaatttagc taacaagacc     3000
tacgatgata catttattca ggtattattg actctgaatt tctcaaaaat gggacattta     3060
tcatttaaag ctttaaaaaa tattattcct tttttagaag aaggtctatc ctacgataaa     3120
gcatgtgaga aggcaggata caactttaag ggaacatcct acacaaaaaa aacaaagtac     3180
ctaccagtta tccctcagaa tacaaatcct gttgtacatc gtgcactttc acagacaaga     3240
aaagttataa atgccattat taaaaaatat ggttctccaa acgcaatcca tattgaaact     3300
gctagagaat tatcgaaaac atttcaagaa agaaaagaaa tagatagtat gtaccaggat     3360
aactctaaaa agaatgaaca cgccattcat aagttaaaag aattggggaa cattaacccc     3420
tcaggaataa atattgtgaa atttaagctt tggaatgaac aagatagtag atgtatgtat     3480
tctggaaaat atatcgaacc acatcgatta tttgaagaag gttatacgga agtagatcat     3540
atactcccct atagccggag cttagatgac agctataaca ataaagcatt aacgctagga     3600
acagaaaatc agggtaaagg aaacaaaact ccttatgaat acatggggaa tacttcaatt     3660
tgggatgaat ttgaaacaag agtacagtca aataaaaaaa tcaacaaaaa gaaacaacaa     3720
aaattacttt tacaaaactt ttcacatgcg agagaacaag agtttattga acgcaatctc     3780
aatgataccc gttatgccac aatatatcta tcatccctta ttcaacaaca cctcatattc     3840
tctgaaagct ctcgtgagaa aaaagttcat acagttagtg gaattataac atctcatttt     3900
cgtagtagat ggggatttaa caaagatagg aaagaggggc atatccatca tgctttagat     3960
gcggtaatcg ttgctgtcac atccgatcac atgattaaaa gagtaacaaa atattataag     4020
ttaaaagagt taaatagaaa ctttcaagcc aaacggatgc agtttcctga accttgggaa     4080
ggatttcgtt tagagttaga agcaagggtt tctccaaatc cccagcaata tttaaagggt     4140
attcgtttta aaaattacgc cgatatcaat ctatccgaaa tcaaacctat ctttgtttca     4200
agaatgccta agcgctctat tactggtgaa ttacatcaag aaacgatccg gaaattcctt     4260
ggttataacg aaaaggggaa agtgctaacc gcaataaaaa caaaattaga agatattcct     4320
tttgattcca atggtgattt ttccatgtat gggaaagaaa ctgatttata cacgtataat     4380
gccataaaag aacgttattt aagtcataaa aaagataaac gcaaatcatt ccaagaacct     4440
ttatacaaac ccacaaaatc aggaggaatt ggaccactta taaaatctat taaaataatt     4500
gatacaagaa ccattgttaa tcctgttaat aaaggtaaag gtgtcgtgta taatagtaaa     4560
attgctcgta ctgatgtatt caaaaaggat gagaagtact atttaattcc catttacaca     4620
attgatctta tgaaaaatat cttacctcaa aaagcaatta cagcaggaaa aggatataag     4680
gattggacaa ccattaatcc cagctttact tttttattta gtctttttcc caatgatcta     4740
atcaaaattg tccccgcaaa aaataaaaca attaaagcta gaacaactgt attgaaaaaa     4800
gaggtattac taccctcact cacaggatat tttaaaggtg ttcatagtgg aactgctggg     4860
attactgttg aaacacacga tggcagtatt atagcaaatg taggttccaa gcaattacta     4920
tcatttgaga aatatcaagt agatgtactt ggacattata caaaaataaa gaaggaaaaa     4980
cgtattggca tggcgatata gaatggtaac aaaaagagcg cagcttgcta atatgaaact     5040
ttcaataggg aaacatacgc aaacaaagaa gatactatct ctgcacaact taatttattt     5100
aaaaaagaaa aaaatcgcat tctaaacaaa tgaaatccct cattttttaa attaaaaaac     5160
cttgtctaat cctctagtga caaggttttt tcagcatcta tcagaacata gcgatgtttc     5220
ttatggaact atagcgtccc ataaacctta aattcatata cagttatcat agcatagcga     5280
tttctcttat ggaactatag ccccgacgat cgtccccatt cttccctgaa caccatagca     5340
tagcgatgct tcttatggaa ctatagcaag agactcggtt ttctgactag gattcagacc     5400
atagcatagc gatgtttctt atggaactat agcactacct agtgcatgaa ttgcttgcaa     5460
tcgaccatag tatagcgatg tttcttatgg aactatagct caccgaacac aaagcgtgta     5520
gccatactaa ccatatcata gcgatgcttc ttatggaact acagctcgcc gcccataaac     5580
aagcttattt tctatcatct tatattaatt tttcttatga aacagtatcc tattggcctt     5640
acttcatgaa gactcaaatg tcataaccgt atttccagat aaaattacat cttatcccat     5700
caagacacac cattctcatt atatactgca atgctttata tatattttta acaaaaatat     5760
atattccaaa cctaaaggac taaatataac ttataaattt acttatcaaa tagcctccag     5820
caaggaattt gtacacttac tcttactttt aaatcagtaa gttttagtaa tacatttaca     5880
taaataatcc tttcgcctat aaacaaaaga attatgttat aatatctact gaacatatga     5940
ataggataac aactacctgc tgttggcaag tagaaattta tctggttctg gtgcaaaaaa     6000
ctaaatgagt tgaaaatgtt ccttcaaact tggctatact ggtattacta ctttaaaaag     6060
gtgtg                                                                 6065

<210>  73
<211>  3204
<212>  DNA
<213>  Unknown

<220>
<223>  cas9 Gene ORF in Locus 42  from Bacillus species

<400>  73
ttgaaatatg tattagggtt ggatattgga atcgcatcct gtggttgggc agtaataaat       60
caagaaaaac atagaataga agatttaggg gttcgtattt ttgataaagc tgaaaacccc      120
aaagatggaa aatctttagc tacacctaga cgtgacgcac gctctaccag gagaatccta      180
cgccgtaaaa aacatagaat gcaacggata aagatacttt tagtaaagca tggcttacta      240
tccaagaccg aactcgacca tctatatgaa agtgctactg agaacaatgt ttgggactta      300
cgtttaaatg ctctagatca cagattaaat ccaaaagagt ttgccagagt tcttattcac      360
cttgctaaaa gaagaggatt taaatctaat agaaaagaaa caactctttc ggaaaacgga      420
caaatcttag aaaacatttc agagaacctg cagattatgg agcaaaaaaa ttatagaact      480
gttggagaaa tgattctaaa agataaaaaa tttgaaaacc ataaaagaaa caaagatggt      540
acttatatcg ggactgttac tcggcaacaa cttcaagaag aaatacaaat gatattccat      600
gcacaacgtt tgtacaaaaa tgatcatgca acagagaaat ttgaaagtag ctacttagaa      660
atctgggcat ctcaacgtcc ctatgcttct aaagatcaaa ttgaaaaaat gattggctac      720
tgtaccttag agccaaaaga aaaaagagtg cctaaagctt cttggtcatt tcaatatttt      780
gtagcgctac aaaccataaa caacctccga ctgatcagta aagacagaat agaagaactc      840
tcctttgaag aaaagaaacg aattatgaat ttagcactcg aaaaatcaat tgttaaatac      900
attgatatcc gaaaattatt atctgttcct aatgaatttc aatttaatag cctatcatat      960
tcagctgata cagtagatac aacggtggaa agtagaaaat gtatagaact caaagaatat     1020
cattctatta acaaggtata taaacaaatt tacggacaga acgccctaaa tttattacct     1080
aaagattacg atacaattgc atacggactt actatcttta aagatgataa agatatccta     1140
gcatatttac aaaataaata cgtaaatgca aaaggaaaat ctataagtaa tttagctaac     1200
aagacctacg atgatacatt tattcaggta ttattgactc tgaatttctc aaaaatggga     1260
catttatcat ttaaagcttt aaaaaatatt attccttttt tagaagaagg tctatcctac     1320
gataaagcat gtgagaaggc aggatacaac tttaagggaa catcctacac aaaaaaaaca     1380
aagtacctac cagttatccc tcagaataca aatcctgttg tacatcgtgc actttcacag     1440
acaagaaaag ttataaatgc cattattaaa aaatatggtt ctccaaacgc aatccatatt     1500
gaaactgcta gagaattatc gaaaacattt caagaaagaa aagaaataga tagtatgtac     1560
caggataact ctaaaaagaa tgaacacgcc attcataagt taaaagaatt ggggaacatt     1620
aacccctcag gaataaatat tgtgaaattt aagctttgga atgaacaaga tagtagatgt     1680
atgtattctg gaaaatatat cgaaccacat cgattatttg aagaaggtta tacggaagta     1740
gatcatatac tcccctatag ccggagctta gatgacagct ataacaataa agcattaacg     1800
ctaggaacag aaaatcaggg taaaggaaac aaaactcctt atgaatacat ggggaatact     1860
tcaatttggg atgaatttga aacaagagta cagtcaaata aaaaaatcaa caaaaagaaa     1920
caacaaaaat tacttttaca aaacttttca catgcgagag aacaagagtt tattgaacgc     1980
aatctcaatg atacccgtta tgccacaata tatctatcat cccttattca acaacacctc     2040
atattctctg aaagctctcg tgagaaaaaa gttcatacag ttagtggaat tataacatct     2100
cattttcgta gtagatgggg atttaacaaa gataggaaag aggggcatat ccatcatgct     2160
ttagatgcgg taatcgttgc tgtcacatcc gatcacatga ttaaaagagt aacaaaatat     2220
tataagttaa aagagttaaa tagaaacttt caagccaaac ggatgcagtt tcctgaacct     2280
tgggaaggat ttcgtttaga gttagaagca agggtttctc caaatcccca gcaatattta     2340
aagggtattc gttttaaaaa ttacgccgat atcaatctat ccgaaatcaa acctatcttt     2400
gtttcaagaa tgcctaagcg ctctattact ggtgaattac atcaagaaac gatccggaaa     2460
ttccttggtt ataacgaaaa ggggaaagtg ctaaccgcaa taaaaacaaa attagaagat     2520
attccttttg attccaatgg tgatttttcc atgtatggga aagaaactga tttatacacg     2580
tataatgcca taaaagaacg ttatttaagt cataaaaaag ataaacgcaa atcattccaa     2640
gaacctttat acaaacccac aaaatcagga ggaattggac cacttataaa atctattaaa     2700
ataattgata caagaaccat tgttaatcct gttaataaag gtaaaggtgt cgtgtataat     2760
agtaaaattg ctcgtactga tgtattcaaa aaggatgaga agtactattt aattcccatt     2820
tacacaattg atcttatgaa aaatatctta cctcaaaaag caattacagc aggaaaagga     2880
tataaggatt ggacaaccat taatcccagc tttacttttt tatttagtct ttttcccaat     2940
gatctaatca aaattgtccc cgcaaaaaat aaaacaatta aagctagaac aactgtattg     3000
aaaaaagagg tattactacc ctcactcaca ggatatttta aaggtgttca tagtggaact     3060
gctgggatta ctgttgaaac acacgatggc agtattatag caaatgtagg ttccaagcaa     3120
ttactatcat ttgagaaata tcaagtagat gtacttggac attatacaaa aataaagaag     3180
gaaaaacgta ttggcatggc gata                                            3204

<210>  74
<211>  1068
<212>  PRT
<213>  Unknown

<220>
<223>  Translation of cas9 Gene ORF in Locus 42  from Bacillus species

<400>  74
Met Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          
Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Thr 
        35                  40                  45              
Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Ile Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys His Gly Leu Leu 
65                  70                  75                  80  
Ser Lys Thr Glu Leu Asp His Leu Tyr Glu Ser Ala Thr Glu Asn Asn 
                85                  90                  95      
Val Trp Asp Leu Arg Leu Asn Ala Leu Asp His Arg Leu Asn Pro Lys 
            100                 105                 110         
Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             
Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 
Asn Ile Ser Glu Asn Leu Gln Ile Met Glu Gln Lys Asn Tyr Arg Thr 
145                 150                 155                 160 
Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         
Glu Glu Ile Gln Met Ile Phe His Ala Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             
His Ala Thr Glu Lys Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 
Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 
Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser 
                245                 250                 255     
Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         
Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Arg Ile 
        275                 280                 285             
Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 
Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 
Ser Ala Asp Thr Val Asp Thr Thr Val Glu Ser Arg Lys Cys Ile Glu 
                325                 330                 335     
Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly 
            340                 345                 350         
Gln Asn Ala Leu Asn Leu Leu Pro Lys Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             
Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Ala Tyr Leu Gln 
    370                 375                 380                 
Asn Lys Tyr Val Asn Ala Lys Gly Lys Ser Ile Ser Asn Leu Ala Asn 
385                 390                 395                 400 
Lys Thr Tyr Asp Asp Thr Phe Ile Gln Val Leu Leu Thr Leu Asn Phe 
                405                 410                 415     
Ser Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         
Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             
Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Lys Lys Thr Lys Tyr Leu Pro 
    450                 455                 460                 
Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 
Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     
Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         
Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             
His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 
Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Ser Arg Cys 
545                 550                 555                 560 
Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     
Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         
Ser Tyr Asn Asn Lys Ala Leu Thr Leu Gly Thr Glu Asn Gln Gly Lys 
        595                 600                 605             
Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asp 
    610                 615                 620                 
Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 
Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser His Ala Arg Glu Gln Glu 
                645                 650                 655     
Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         
Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Glu 
        675                 680                 685             
Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Phe Arg Ser 
    690                 695                 700                 
Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 
Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Lys Arg 
                725                 730                 735     
Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Phe Gln Ala 
            740                 745                 750         
Lys Arg Met Gln Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             
Glu Ala Arg Val Ser Pro Asn Pro Gln Gln Tyr Leu Lys Gly Ile Arg 
    770                 775                 780                 
Phe Lys Asn Tyr Ala Asp Ile Asn Leu Ser Glu Ile Lys Pro Ile Phe 
785                 790                 795                 800 
Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     
Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         
Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ser Asn Gly Asp 
        835                 840                 845             
Phe Ser Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 
Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 
Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     
Lys Ser Ile Lys Ile Ile Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         
Lys Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             
Phe Lys Lys Asp Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 
Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 
Tyr Lys Asp Trp Thr Thr Ile Asn Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     
Leu Phe Pro Asn Asp Leu Ile Lys Ile Val Pro Ala Lys Asn Lys Thr 
            980                 985                 990         
Ile Lys Ala Arg Thr Thr Val Leu  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             
Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             
Thr Val  Glu Thr His Asp Gly  Ser Ile Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             
Lys Gln  Leu Leu Ser Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             
His Tyr  Thr Lys Ile Lys Lys  Glu Lys Arg Ile Gly  Met Ala Ile 
    1055                 1060                 1065             

<210>  75
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  CRISPR Array Repeat Consensus for Locus 42  from Bacillus species

<400>  75
atcatagcat agcgatgttt cttatggaac tatagc                                 36

<210>  76
<211>  36
<212>  DNA
<213>  unknown

<220>
<223>  CRISPR Array Anti-Repeat for Locus 42  from Bacillus species

<400>  76
atcatatcat agcgatgttt cttaagttac tatagt                                 36

<210>  77
<211>  18
<212>  RNA
<213>  unknown

<220>
<223>   Repeat Region in Single Guide RNA for Locus 42 from Bacillus 
       species

<400>  77
gcuauaguuc cauaagaa                                                     18

<210>  78
<211>  18
<212>  RNA
<213>  unknown

<220>
<223>  Anti-Repeat Region in sgRNA for Locus 42 from Bacillus species

<400>  78
uucuuaaguu acuauagu                                                     18

<210>  79
<211>  99
<212>  RNA
<213>  unknown

<220>
<223>  Prime tracrRNA in sgRNA for Locus 42 from Bacillus species

<400>  79
aagggcaaug acccguggcg uuuggggauc gccuuauccu gguuuggaua uucuccccau       60
guuaaaagca ccuaagcaua gcgcuauggu gcuuuuauu                              99

<210>  80
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthesized sgRNA Solution for Locus 42

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  80
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cauaagaaga aauucuuaag uuacuauagu       60
aagggcaaug acccguggcg uuuggggauc gccuuauccu gguuuggaua uucuccccau      120
guuaaaagca ccuaagcaua gcgcuauggu gcuuuuauu                             159