                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       PELES, Elior
       HYUNJEONG, Yang
 
<120>  METHOD FOR MODULATING MYELINATION

<130>  69090

<150>  US 62/304,242
<151>  2016-03-06

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
gggtgggatt agataaatgc ctgctct                                           27


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ggccaagaga gaattggaga tgctc                                             25


<210>  3
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
aacgggtctg cagatgactg ggttc                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
ggccaagaga gaattggaga tgctc                                             25


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
cctgcaagat cgtgcccta                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
agtacatctg gacgttggtg g                                                 21


<210>  7
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
ctttaggtgg gcatagagc                                                    19


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
tggagaactg gttgatgagg c                                                 21


<210>  9
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
tgccgctgtt ttggataa                                                     18


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
cgcctcggaa atagtatttg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
ccagagcggc tgtctcttcc                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
catccttgac tccatcgggc gc                                                22


<210>  13
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
gagcaccctg tgctgctcac cgagg                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  14
gtggtggtga agctgtagcc acgct                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  15
tgtcactacc ttcaccttat g                                                 21


<210>  16
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  16
gctccaaccc agataacg                                                     18


<210>  17
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  17
cagctacgag gagtccacct ggagcac                                           27


<210>  18
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
cggtagggct gcctccagac cgttcat                                           27


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
aactccaagc tggagaaggc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
gtcaggaact gtaccgcctc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
aatgactgtg aagcacctcc                                                   20


<210>  22
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
atttccccaa cacgctcgg                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
cctgcatcac cagagacctg                                                   20


<210>  24
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
ttcgacataa gctcagaagg gaa                                               23


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
catcaccaac agcgaatggc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
cactgcttac aggaggcgaa                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
caaccgggtc aagttggtca                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
ctcatcttct tgttggccgc                                                   20


<210>  29
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
gctcgcccag gtgttttgt                                                    19


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
gcatggaacg tggttggaat                                                   20


<210>  31
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
agagccaggt tctcctccg                                                    19


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
actagacacc aggctggcgt                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
ggttccagaa ccatcgctac a                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
gcttcgatcc tggcatccat                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
catgaccgag agccaagtga                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
gcttcttttt agccgacgcc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  37
agcccaggtg aagacagaga                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  38
agtcaaactg gggtcgtgag                                                   20


<210>  39
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  39
ttgagctctc aacgaacgct ttgc                                              24


<210>  40
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  40
tcagacccta agcaactggc agaa                                              24


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  41
tggcaacttc acctaccaca                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  42
gtggaacctc tgcaaaaagc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  43
ggtcggtgtg aacggatttg                                                   20


<210>  44
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  44
tcgttgatgg caacaatctc cact                                              24


<210>  45
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ShRNA oligonucleotide sequence

<400>  45
gatctcccca acgtccagat gtactattca agagatagta catctggacg ttggtttttc       60


<210>  46
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ShRNA oligonucleotide sequence

<400>  46
tcgagaaaaa ccaacgtcca gatgtactat ctcttgaata gtacatctgg acgttgggga       60


<210>  47
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ShRNA oligonucleotide sequence

<400>  47
gatctccgaa ggccagtacc cgtggattca agagatccac gggtactggc cttctttttc       60


<210>  48
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ShRNA oligonucleotide sequence

<400>  48
cgagaaaaag aaggccagta cccgtggatc tcttgaatcc acgggtactg gccttcgga        59


<210>  49
<211>  9
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNA oligonucleotide sequences that can be used to form a loop

<400>  49
uucaagaga                                                                9


<210>  50
<211>  9
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNA oligonucleotide sequences that can be used to form a loop

<400>  50
uuuguguag                                                                9


<210>  51
<211>  613
<212>  PRT
<213>  homo sapiens

<400>  51

Met Arg Ala Pro Gly Ala Leu Leu Ala Arg Met Ser Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Lys Val Ser Ala Ser Ser Ala Leu Gly Val Ala Pro 
            20                  25                  30          


Ala Ser Arg Asn Glu Thr Cys Leu Gly Glu Ser Cys Ala Pro Thr Val 
        35                  40                  45              


Ile Gln Arg Arg Gly Arg Asp Ala Trp Gly Pro Gly Asn Ser Ala Arg 
    50                  55                  60                  


Asp Val Leu Arg Ala Arg Ala Pro Arg Glu Glu Gln Gly Ala Ala Phe 
65                  70                  75                  80  


Leu Ala Gly Pro Ser Trp Asp Leu Pro Ala Ala Pro Gly Arg Asp Pro 
                85                  90                  95      


Ala Ala Gly Arg Gly Ala Glu Ala Ser Ala Ala Gly Pro Pro Gly Pro 
            100                 105                 110         


Pro Thr Arg Pro Pro Gly Pro Trp Arg Trp Lys Gly Ala Arg Gly Gln 
        115                 120                 125             


Glu Pro Ser Glu Thr Leu Gly Arg Gly Asn Pro Thr Ala Leu Gln Leu 
    130                 135                 140                 


Phe Leu Gln Ile Ser Glu Glu Glu Glu Lys Gly Pro Arg Gly Ala Gly 
145                 150                 155                 160 


Ile Ser Gly Arg Ser Gln Glu Gln Ser Val Lys Thr Val Pro Gly Ala 
                165                 170                 175     


Ser Asp Leu Phe Tyr Trp Pro Arg Arg Ala Gly Lys Leu Gln Gly Ser 
            180                 185                 190         


His His Lys Pro Leu Ser Lys Thr Ala Asn Gly Leu Ala Gly His Glu 
        195                 200                 205             


Gly Trp Thr Ile Ala Leu Pro Gly Arg Ala Leu Ala Gln Asn Gly Ser 
    210                 215                 220                 


Leu Gly Glu Gly Ile His Glu Pro Gly Gly Pro Arg Arg Gly Asn Ser 
225                 230                 235                 240 


Thr Asn Arg Arg Val Arg Leu Lys Asn Pro Phe Tyr Pro Leu Thr Gln 
                245                 250                 255     


Glu Ser Tyr Gly Ala Tyr Ala Val Met Cys Leu Ser Val Val Ile Phe 
            260                 265                 270         


Gly Thr Gly Ile Ile Gly Asn Leu Ala Val Met Cys Ile Val Cys His 
        275                 280                 285             


Asn Tyr Tyr Met Arg Ser Ile Ser Asn Ser Leu Leu Ala Asn Leu Ala 
    290                 295                 300                 


Phe Trp Asp Phe Leu Ile Ile Phe Phe Cys Leu Pro Leu Val Ile Phe 
305                 310                 315                 320 


His Glu Leu Thr Lys Lys Trp Leu Leu Glu Asp Phe Ser Cys Lys Ile 
                325                 330                 335     


Val Pro Tyr Ile Glu Val Ala Ser Leu Gly Val Thr Thr Phe Thr Leu 
            340                 345                 350         


Cys Ala Leu Cys Ile Asp Arg Phe Arg Ala Ala Thr Asn Val Gln Met 
        355                 360                 365             


Tyr Tyr Glu Met Ile Glu Asn Cys Ser Ser Thr Thr Ala Lys Leu Ala 
    370                 375                 380                 


Val Ile Trp Val Gly Ala Leu Leu Leu Ala Leu Pro Glu Val Val Leu 
385                 390                 395                 400 


Arg Gln Leu Ser Lys Glu Asp Leu Gly Phe Ser Gly Arg Ala Pro Ala 
                405                 410                 415     


Glu Arg Cys Ile Ile Lys Ile Ser Pro Asp Leu Pro Asp Thr Ile Tyr 
            420                 425                 430         


Val Leu Ala Leu Thr Tyr Asp Ser Ala Arg Leu Trp Trp Tyr Phe Gly 
        435                 440                 445             


Cys Tyr Phe Cys Leu Pro Thr Leu Phe Thr Ile Thr Cys Ser Leu Val 
    450                 455                 460                 


Thr Ala Arg Lys Ile Arg Lys Ala Glu Lys Ala Cys Thr Arg Gly Asn 
465                 470                 475                 480 


Lys Arg Gln Ile Gln Leu Glu Ser Gln Met Asn Cys Thr Val Val Ala 
                485                 490                 495     


Leu Thr Ile Leu Tyr Gly Phe Cys Ile Ile Pro Glu Asn Ile Cys Asn 
            500                 505                 510         


Ile Val Thr Ala Tyr Met Ala Thr Gly Val Ser Gln Gln Thr Met Asp 
        515                 520                 525             


Leu Leu Asn Ile Ile Ser Gln Phe Leu Leu Phe Phe Lys Ser Cys Val 
    530                 535                 540                 


Thr Pro Val Leu Leu Phe Cys Leu Cys Lys Pro Phe Ser Arg Ala Phe 
545                 550                 555                 560 


Met Glu Cys Cys Cys Cys Cys Cys Glu Glu Cys Ile Gln Lys Ser Ser 
                565                 570                 575     


Thr Val Thr Ser Asp Asp Asn Asp Asn Glu Tyr Thr Thr Glu Leu Glu 
            580                 585                 590         


Leu Ser Pro Phe Ser Thr Ile Arg Arg Glu Met Ser Thr Phe Ala Ser 
        595                 600                 605             


Val Gly Thr His Cys 
    610             


<210>  52
<211>  3815
<212>  DNA
<213>  homo sapiens

<400>  52
ttagtgagtg gtgaaccacc aggggatccc gtctccccac aaaccagtat ctctccgagg       60

aggaggcgaa ggagtgggag gaggcaacga gccgagagtc gagcttcgcg ggcgcgcgca      120

gcggctggag cgcgggggcg aggccgggcc acctcccctt cccggccgcg cactgcctgg      180

cccgcggcgg ttccaggcac cacccttccc gtccgggctg agcccgctgt ggcagtgact      240

agctcccgcg gctagcggca ctgtccaccg acgagcggcg ccctcttctc ccccttctcc      300

ccacgatttc cttctctgcg gcggcacgcc gtccagcagc ctgcttcgcc ccgtcgtcaa      360

ctttgagctg gaggagaagc aactttggca gtggccgcgg ggttggaatc ccgcttctcc      420

tcggcagcag taggctcgca agtcgctggg gttaggtggg gcaagagttt cgccggcgca      480

tcagcgctgc ttcggactgt ttgcaacgtg tttccagcga gctgggagcg gggttgtgac      540

tgcgagtcgt ctgggggagg gggacttgtt tttcttttcc tctagagacc tcggcttgca      600

actggatcaa acgctgtcga aaggatgtaa ataggcagag caactgttac caagaaggcc      660

accaccccca cccaaaggca gtgaggagtg tggggcttcg tctgggctcc cccgagtctc      720

aacagtaatc aacagtcagg tgttgattgc aacttttcaa ggtcagccac cgggagtagc      780

ctattccctc taggaacctt ggagggcata ccttgctggg actcaacttg gctgagaaat      840

gcacaagatg ccaaaggagg aaggattata gggggcgtgt gtgtgacccc caagaccgat      900

cttccgctat caccctaatc tccggttccc cgctacccgg gcgggggtga gtatgtgaca      960

tgtgcctaac tctcagcagc aacttcggca gcaggtgtcg atcctaacta agcaggagct     1020

gcggctgccg ggtgtgccct caccaagcca tgcgagcccc gggcgcgctt ctcgcccgca     1080

tgtcgcggct actgcttctg ctactgctca aggtgtctgc ctcttctgcc ctcggggtcg     1140

cccctgcgtc cagaaacgaa acttgtctgg gggagagctg tgcacctaca gtgatccagc     1200

gccgcggcag ggacgcctgg ggaccgggaa attctgcaag agacgttctg cgagcccgag     1260

cacccaggga ggagcagggg gcagcgtttc ttgcgggacc ctcctgggac ctgccggcgg     1320

ccccgggccg tgacccggct gcaggcagag gggcggaggc gtcggcagcc ggacccccgg     1380

gacctccaac caggccacct ggcccctgga ggtggaaagg tgctcggggt caggagcctt     1440

ctgaaacttt ggggagaggg aaccccacgg ccctccagct cttccttcag atctcagagg     1500

aggaagagaa gggtcccaga ggcgctggca tttccgggcg tagccaggag cagagtgtga     1560

agacagtccc cggagccagc gatctttttt actggccaag gagagccggg aaactccagg     1620

gttcccacca caagcccctg tccaagacgg ccaatggact ggcggggcac gaagggtgga     1680

caattgcact cccgggccgg gcgctggccc agaatggatc cttgggtgaa ggaatccatg     1740

agcctggggg tccccgccgg ggaaacagca cgaaccggcg tgtgagactg aagaacccct     1800

tctacccgct gacccaggag tcctatggag cctacgcggt catgtgtctg tccgtggtga     1860

tcttcgggac cggcatcatt ggcaacctgg cggtgatgtg catcgtgtgc cacaactact     1920

acatgcggag catctccaac tccctcttgg ccaacctggc cttctgggac tttctcatca     1980

tcttcttctg ccttccgctg gtcatcttcc acgagctgac caagaagtgg ctgctggagg     2040

acttctcctg caagatcgtg ccctatatag aggtcgcttc tctgggagtc accactttca     2100

ccttatgtgc tctgtgcata gaccgcttcc gtgctgccac caacgtacag atgtactacg     2160

aaatgatcga aaactgttcc tcaacaactg ccaaacttgc tgttatatgg gtgggagctc     2220

tattgttagc acttccagaa gttgttctcc gccagctgag caaggaggat ttggggttta     2280

gtggccgagc tccggcagaa aggtgcatta ttaagatctc tcctgattta ccagacacca     2340

tctatgttct agccctcacc tacgacagtg cgagactgtg gtggtatttt ggctgttact     2400

tttgtttgcc cacgcttttc accatcacct gctctctagt gactgcgagg aaaatccgca     2460

aagcagagaa agcctgtacc cgagggaata aacggcagat tcaactagag agtcagatga     2520

actgtacagt agtggcactg accattttat atggattttg cattattcct gaaaatatct     2580

gcaacattgt tactgcctac atggctacag gggtttcaca gcagacaatg gacctcctta     2640

atatcatcag ccagttcctt ttgttcttta agtcctgtgt caccccagtc ctccttttct     2700

gtctctgcaa acccttcagt cgggccttca tggagtgctg ctgctgttgc tgtgaggaat     2760

gcattcagaa gtcttcaacg gtgaccagtg atgacaatga caacgagtac accacggaac     2820

tcgaactctc gcctttcagt accatacgcc gtgaaatgtc cacttttgct tctgtcggaa     2880

ctcattgctg aaggacagta cttggttggg tcagatttat ttgtttgatt ttcatatccc     2940

gtgaaagttt ttaattcata tttttcctta tagggaaaaa tgcaaaaaag aaacaataaa     3000

gaaagaaata ttaactactg tagaactgat tttacaaatt aatatttgtg ctttgaaaaa     3060

aagtttctat ttagttattt aagaagaatg agaaggccaa tagttttaga ttattttatc     3120

tggtatggtg ctaatatttt atttgaaaaa agttactgca acttaactta aaattgctaa     3180

cgttttttct tcttttaaaa atacaattat tgtatattga ttatagcaat gtgattttgt     3240

aggttatttt atatttgagt tgtgattgaa agtatgttgt atatggtatt gtgagatgat     3300

ttgtacttgg aagcattcac aaagtagcac caaataaatt acactttatt ctttaatgtc     3360

attgtcaatc tacttttaac caatattcaa taaatcttct aattgcctta aagatacaat     3420

tactggttct atgcacaatt taaaaccggc cttactgttt tataacgtat tttcttttaa     3480

ggcaggtaat cattatgtta taaagaagtt tttctaatag cagtatttta tatgcatgat     3540

tcataaaact atgttgtatg ttaaaacaaa gctgtatttt taatattcag gtatagatgt     3600

caaattactt ctgaatactt ataaaatatg aataaatagc agagtaggaa gaaagtttct     3660

tttttaaaaa attcacctct gaactagcac atagagctac agattttccc ttggggaatt     3720

atgggcagaa tcaagaattt taaaatgcag ttgtcatctg atttcctctg aacactgacc     3780

tttgaagctt tgtgaatcct acgtaaagca ctctg                                3815


<210>  53
<211>  1174
<212>  DNA
<213>  homo sapiens

<400>  53
ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg       60

ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca      120

ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga      180

ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta      240

catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg      300

cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg      360

ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct      420

gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac      480

tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct      540

ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct      600

aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct      660

ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac      720

gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga      780

catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg      840

caagcactac ctggatcagc tcaaccacat tctgggcatc ctgggctccc catcccagga      900

ggacctgaat tgtatcatca acatgaaggc ccgaaactac ctacagtctc tgccctccaa      960

gaccaaggtg gcttgggcca agcttttccc caagtcagac tccaaagccc ttgacctgct     1020

ggaccggatg ttaaccttta accccaataa acggatcaca gtggaggaag cgctggctca     1080

cccctacctg gagcagtact atgacccgac ggatgaggtg ggccagtccc cagcagcagt     1140

ggggctgggg gcaggggagc aggggggcac gtag                                 1174


<210>  54
<211>  1770
<212>  DNA
<213>  homo sapiens

<400>  54
ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg       60

ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca      120

ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga      180

ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta      240

catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg      300

cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg      360

ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct      420

gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac      480

tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct      540

ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct      600

aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct      660

ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac      720

gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga      780

catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg      840

caagcactac ctggatcagc tcaaccacat tctggccctt gacctgctgg accggatgtt      900

aacctttaac cccaataaac ggatcacagt ggaggaagcg ctggctcacc cctacctgga      960

gcagtactat gacccgacgg atgagccagt ggccgaggag cccttcacct tcgccatgga     1020

gctggatgac ctacctaagg agcggctgaa ggagctcatc ttccaggaga cagcacgctt     1080

ccagcccgga gtgctggagg ccccctagcc cagacagaca tctctgcacc ctggggcctg     1140

gacctgcctc ctgcctgccc ctctcccgcc agactgttag aaaatggaca ctgtgcccag     1200

cccggacctt ggcagcccag gccggggtgg agcatgggcc tggccacctc tctcctttgc     1260

tgaggcctcc agcttcaggc aggccaaggc cttctcctcc ccacccgccc tccccacggg     1320

gcctcgggac ctcaggtggc cccagttcaa tctcccgctg ctgctgctgc gcccttacct     1380

tccccagcgt cccagtctct ggcagttctg gaatggaagg gttctggctg ccccaacctg     1440

ctgaagggca gaggtggagg gtggggggcg ctgagtaggg actcagggcc atgcctgccc     1500

ccctcatctc attcaaaccc caccctagtt tccctgaagg aacattcctt agtctcaagg     1560

gctagcatcc ctgaggagcc aggccgggcc gaatcccctc cctgtcaaag ctgtcacttc     1620

gcgtgccctc gctgcttctg tgtgtggtga gcagaagtgg agctgggggg cgtggagagc     1680

ccggcgcccc tgccacctcc ctgacccgtc taatatataa atatagagat gtgtctatgg     1740

ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1770


<210>  55
<211>  1902
<212>  DNA
<213>  homo sapiens

<400>  55
ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg       60

ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca      120

ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga      180

ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta      240

catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg      300

cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg      360

ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct      420

gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac      480

tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct      540

ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct      600

aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct      660

ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac      720

gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga      780

catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg      840

caagcactac ctggatcagc tcaaccacat tctgggcatc ctgggctccc catcccagga      900

ggacctgaat tgtatcatca acatgaaggc ccgaaactac ctacagtctc tgccctccaa      960

gaccaaggtg gcttgggcca agcttttccc caagtcagac tccaaagccc ttgacctgct     1020

ggaccggatg ttaaccttta accccaataa acggatcaca gtggaggaag cgctggctca     1080

cccctacctg gagcagtact atgacccgac ggatgagcca gtggccgagg agcccttcac     1140

cttcgccatg gagctggatg acctacctaa ggagcggctg aaggagctca tcttccagga     1200

gacagcacgc ttccagcccg gagtgctgga ggccccctag cccagacaga catctctgca     1260

ccctggggcc tggacctgcc tcctgcctgc ccctctcccg ccagactgtt agaaaatgga     1320

cactgtgccc agcccggacc ttggcagccc aggccggggt ggagcatggg cctggccacc     1380

tctctccttt gctgaggcct ccagcttcag gcaggccaag gccttctcct ccccacccgc     1440

cctccccacg gggcctcggg acctcaggtg gccccagttc aatctcccgc tgctgctgct     1500

gcgcccttac cttccccagc gtcccagtct ctggcagttc tggaatggaa gggttctggc     1560

tgccccaacc tgctgaaggg cagaggtgga gggtgggggg cgctgagtag ggactcaggg     1620

ccatgcctgc ccccctcatc tcattcaaac cccaccctag tttccctgaa ggaacattcc     1680

ttagtctcaa gggctagcat ccctgaggag ccaggccggg ccgaatcccc tccctgtcaa     1740

agctgtcact tcgcgtgccc tcgctgcttc tgtgtgtggt gagcagaagt ggagctgggg     1800

ggcgtggaga gcccggcgcc cctgccacct ccctgacccg tctaatatat aaatatagag     1860

atgtgtctat ggctgaaaaa aaaaaaaaaa aaaaaaaaaa aa                        1902


<210>  56
<211>  5916
<212>  DNA
<213>  homo sapiens

<400>  56
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg       60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt      120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga      180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac      240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac      300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc      360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag      420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat      480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat      540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac      600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc      660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc      720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac      780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg      840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa      900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt      960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct     1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca     1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag     1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt     1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag     1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct     1320

taaatttgtc aggacaaggg ctcagaggac tggacgtgct cagacatcgg tgttcttctt     1380

cccagttctt gacccctggt cctgtctcca gcccgtcttg gcttatccac tttgactcct     1440

ttgagccgtt tggaggggcg gtttctggta gttgtggctt ttatgctttc aaagaatttc     1500

ttcagtccag agaattcctc ctggcagccc tgtgtgtgtc acccattggt gacctgcggc     1560

agtatgtact tcagtgcacc tactgcttac tgttgcttta gtcactaatt gctttctggt     1620

ttgaaagatg cagtggttcc tccctctcct gaatcctttt ctacatgatg ccctgctgac     1680

catgcagccg caccagagag agattcttcc ccaattggct ctagtcactg gcatctcact     1740

ttatgatagg gaaggctact acctagggca ctttaagtca gtgacagccc cttatttgca     1800

cttcaccttt tgaccataac tgtttcccca gagcaggagc ttgtggaaat accttggctg     1860

atgttgcagc ctgcagcaag tgcttccgtc tccggaatcc ttggggagca cttgtccacg     1920

tcttttctca tatcatggta gtcactaaca tatataaggt atgtgctatt ggcccagctt     1980

ttagaaaatg cagtcatttt tctaaataaa aaggaagtac tgcacccagc agtgtcactc     2040

tgtagttact gtggtcactt gtaccatata gaggtgtaac acttgtcaag aagcgttatg     2100

tgcagtactt aatgtttgta agacttacaa aaaaagattt aaagtggcag cttcactcga     2160

catttggtga gagaagtaca aaggttgcag tgctgagctg tgggcggttt ctggggatgt     2220

cccagggtgg aactccacat gctggtgcat atacgccctt gagctacttc aaatgtgggt     2280

gtttcagtaa ccacgttcca tgcctgagga tttagcagag aggaacactg cgtctttaaa     2340

tgagaaagta tacaattctt tttccttcta cagcatgtca gcatctcaag ttcatttttc     2400

aacctacagt ataacaattt gtaataaagc ctccaggagc tcatgacgtg aagcactgtt     2460

ctgtcctcaa gtactcaaat atttctgata ctgctgagtc agactgtcag aaaaagctag     2520

cactaactcg tgtttggagc tctatccata ttttactgat ctctttaagt atttgttcct     2580

gccactgtgt actgtggagt tgactcggtg ttctgtccca gtgcggtgcc tcctcttgac     2640

ttccccactg ctctctgtgg tgagaaattt gccttgttca ataattactg taccctcgca     2700

tgactgttac agctttctgt gcagagatga ctgtccaagt gccacatgcc tacgattgaa     2760

atgaaaactc tattgttacc tctgagttgt gttccacgga aaatgctatc cagcagatca     2820

tttaggaaaa ataattctat ttttagcttt tcatttctca gctgtccttt tttcttgttt     2880

gatttttgac agcaatggag aatgggttat ataaagactg cctgctaata tgaacagaaa     2940

tgcatttgta attcatgaaa ataaatgtac atcttctatc ttcacattca tgttaagatt     3000

cagtgttgct ttcctctgga tcagcgtgtc tgaatggaca gtcaggttca ggttgtgctg     3060

aacacagaaa tgctcacagg cctcactttg ccgcccaggc actggcccag cacttggatt     3120

tacataagat gagttagaaa ggtacttctg tagggtcctt tttacctctg ctcggcagag     3180

aatcgatgct gtcatgttcc tttattcaca atcttaggtc tcaaatattc tgtcaaaccc     3240

taacaaagaa gccccgacat ctcaggttgg attccctggt tctctctaaa gagggcctgc     3300

ccttgtgccc cagaggtgct gctgggcaca gccaagagtt gggaagggcc gccccacagt     3360

acgcagtcct caccacccag cccagggtgc tcacgctcac cactcctgtg gctgaggaag     3420

gatagctggc tcatcctcgg aaaacagacc cacatctcta ttcttgccct gaaatacgcg     3480

cttttcactt gcgtgctcag agctgccgtc tgaaggtcca cacagcattg acgggacaca     3540

gaaatgtgac tgttaccgga taacactgat tagtcagttt tcatttataa aaaagcattg     3600

acagttttat tactcttgtt tctttttaaa tggaaagtta ctattataag gttaatttgg     3660

agtcctcttc taaatagaaa accatatcct tggctactaa catctggaga ctgtgagctc     3720

cttcccattc cccttcctgg tactgtggag tcagattggc atgaaaccac taacttcatt     3780

ctagaatcat tgtagccata agttgtgtgc tttttattaa tcatgccaaa cataatgtaa     3840

ctgggcagag aatggtccta accaaggtac ctatgaaaag cgctagctat catgtgtagt     3900

agatgcatca ttttggctct tcttacattt gtaaaaatgt acagattagg tcatcttaat     3960

tcatattagt gacacggaac agcacctcca ctatttgtat gttcaaataa gctttcagac     4020

taatagcttt tttggtgtct aaaatgtaag caaaaaattc ctgctgaaac attccagtcc     4080

tttcatttag tataaaagaa atactgaaca agccagtggg atggaattga aagaactaat     4140

catgaggact ctgtcctgac acaggtcctc aaagctagca gagatacgca gacattgtgg     4200

catctgggta gaagaatact gtattgtgtg tgcagtgcac agtgtgtggt gtgtgcacac     4260

tcattccttc tgctcttggg cacaggcagt gggtgtagag gtaaccagta gctttgagaa     4320

gctacatgta gctcaccagt ggttttctct aaggaatcac aaaagtaaac tacccaacca     4380

catgccacgt aatatttcag ccattcagag gaaactgttt tctctttatt tgcttatatg     4440

ttaatatggt ttttaaattg gtaactttta tatagtatgg taacagtatg ttaatacaca     4500

catacatacg cacacatgct ttgggtcctt ccataatact tttatatttg taaatcaatg     4560

ttttggagca atcccaagtt taagggaaat atttttgtaa atgtaatggt tttgaaaatc     4620

tgagcaatcc ttttgcttat acatttttaa agcatttgtg ctttaaaatt gttatgctgg     4680

tgtttgaaac atgatactcc tgtggtgcag atgagaagct ataacagtga atatgtggtt     4740

tctcttacgt catccacctt gacatgatgg gtcagaaaca aatggaaatc cagagcaagt     4800

cctccagggt tgcaccaggt ttacctaaag cttgttgcct tttcttgtgc tgtttatgcg     4860

tgtagagcac tcaagaaagt tctgaaactg ctttgtatct gctttgtact gttggtgcct     4920

tcttggtatt gtaccccaaa attctgcata gattatttag tataatggta agttaaaaaa     4980

tgttaaagga agattttatt aagaatctga atgtttattc attatattgt tacaatttaa     5040

cattaacatt tatttgtggt atttgtgatt tggttaatct gtataaaaat tgtaagtaga     5100

aaggtttata tttcatctta attcttttga tgttgtaaac gtacttttta aaagatggat     5160

tatttgaatg tttatggcac ctgacttgta aaaaaaaaaa actacaaaaa aatccttaga     5220

atcattaaat tgtgtccctg tattaccaaa ataacacagc accgtgcatg tatagtttaa     5280

ttgcagtttc atctgtgaaa acgtgaaatt gtctagtcct tcgttatgtt ccccagatgt     5340

cttccagatt tgctctgcat gtggtaactt gtgttagggc tgtgagctgt tcctcgagtt     5400

gaatggggat gtcagtgctc ctagggttct ccaggtggtt cttcagacct tcacctgtgg     5460

gggggggggt aggcggtgcc cacgcccatc tcctcatcct cctgaacttc tgcaacccca     5520

ctgctgggca gacatcctgg gcaacccctt ttttcagagc aagaagtcat aaagatagga     5580

tttcttggac atttggttct tatcaatatt gggcattatg taatgactta tttacaaaac     5640

aaagatactg gaaaatgttt tggatgtggt gttatggaaa gagcacaggc cttggaccca     5700

tccagctggg ttcagaacta ccccctgctt ataactgcgg ctggctgtgg gccagtcatt     5760

ctgcgtctct gctttcttcc tctgcttcag actgtcagct gtaaagtgga agcaatatta     5820

cttgccttgt atatggtaaa gattataaaa atacatttca actgttcagc atagtacttc     5880

aaagcaagta ctcagtaaat agcaagtctt tttaaa                               5916


<210>  57
<211>  1514
<212>  DNA
<213>  homo sapiens

<400>  57
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg       60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt      120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga      180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac      240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac      300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc      360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag      420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat      480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat      540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac      600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc      660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc      720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac      780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg      840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa      900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt      960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct     1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca     1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag     1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt     1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag     1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct     1320

taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt     1380

ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct     1440

tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa     1500

aaaaaaaaaa aaaa                                                       1514


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  58
gggtgggatt agataaatgc ctgctct                                           27


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  59
ggccaagaga gaattggaga tgctc                                             25


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  60
aacgggtctg cagatgactg ggttc                                             25


<210>  61
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  61
ggccaagaga gaattggaga tgctc                                             25


