                         SEQUENCE LISTING

<110>  MedImmune LIMITED
       JERMUTUS, Lutz
       AMBERY, Philip Duncan
       BEDNAREK, Maria A.
       PETRONE, Marcella
 
<120>  GLUCAGON AND GLP-1 CO-AGONISTS FOR THE TREATMENT OF OBESITY

<130>  GLPGG-200-PCT

<150>  62/306,121
<151>  2016-03-10

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, Arg, or Ser

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glu, Arg, Gln, or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Arg, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Arg, Lys, or Gln

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Ala or Gln

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Glu or Val

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Lys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Gly or Arg

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Gly Xaa 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, Arg, or Ser

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glu, Arg, Gln, or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Arg, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Glu or Val

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Arg Asp Phe Val Ala Trp Leu Xaa Ala Gly Gly 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, Arg, or Ser

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Tyr

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Glu or Val

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Xaa Ala Gly Gly 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, Arg, or Ser

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Tyr

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Glu or Val

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Xaa Ala Gly Gly 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Val Ala Gly Gly 
            20                  25                  30  


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Val Ala Gly Gly 
            20                  25                  30  


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, or Arg

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Glu, Arg, or Ser

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  12
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Glu Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Glu Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Val Ala Gly Gly 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Glu Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Glu Tyr Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  21

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  22

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Lys Gly Arg 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric GLP-1/glucagon peptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  23

His Gly Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Asp Phe Val Gln Trp Leu Val Ala Gly Gly 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G931


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Arg Asp Phe Val Ala Trp Leu Val Ala Gly Gly 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G934


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Lys Gly Arg 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G973


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lysine with a palmitoyl group conjugated to the epsilon nitrogen,
       through a gamma glutamic acid linker

<400>  26

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ser Ala Arg Asp Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  


