                         SEQUENCE LISTING

<110>  Universidad Santo Toms
 
<120>  Protena Vainillil alcohol oxidasa recombinante

<130>  VAOr

<150>  CL 572-2016
<151>  2016-03-10

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2944
<212>  DNA
<213>  Chimeric

<400>  1
atgggtacca aaactgaaga aggtaaactg gtaatctgga ttaacggcga taaaggctat       60

aacggtctcg ctgaagtcgg taagaaattc gagaaagata ccggaattaa agtcaccgtt      120

gagcatccgg ataaactgga agagaaattc ccacaggttg cggcaactgg cgatggccct      180

gacattatct tctgggcaca cgaccgcttt ggtggctacg ctcaatctgg cctgttggct      240

gaaatcaccc cggacaaagc gttccaggac aagctgtatc cgtttacctg ggatgccgta      300

cgttacaacg gcaagctgat tgcttacccg atcgctgttg aagcgttatc gctgatttat      360

aacaaagatc tgctgccgaa cccgccaaaa acctgggaag agatcccggc gctggataaa      420

gaactgaaag cgaaaggtaa gagcgcgctg atgttcaacc tgcaagaacc gtacttcacc      480

tggccgctga ttgctgctga cgggggttat gcgttcaagt atgaaaacgg caagtacgac      540

attaaagacg tgggcgtgga taacgctggc gcgaaagcgg gtctgacctt cctggttgac      600

ctgattaaaa acaaacacat gaatgcagac accgattact ccatcgcaga agctgccttt      660

aataaaggcg aaacagcgat gaccatcaac ggcccgtggg catggtccaa catcgacacc      720

agcaaagtga attatggtgt aacggtactg ccgaccttca agggtcaacc atccaaaccg      780

ttcgttggcg tgctgagcgc aggtattaac gccgccagtc cgaacaaaga gctggcaaaa      840

gagttcctcg aaaactatct gctgactgat gaaggtctgg aagcggttaa taaagacaaa      900

ccgctgggtg ccgtagcgct gaagtcttac gaggaagagt tggcgaaaga tccacgtatt      960

gccgccacca tggaaaacgc ccagaaaggt gaaatcatgc cgaacatccc gcagatgtcc     1020

gctttctggt atgccgtgcg tactgcggtg atcaacgccg ccagcggtcg tcagactgtc     1080

gatgaagccc tgaaagacgc gcagactggt accggatctt acatcacaag tttgtacaaa     1140

aaagcaggct ccgcggccgc ccccttcacc atgtccaaga cacaggaatt caggcctttg     1200

acactgccac ccaagctgtc gttaagtgac ttcaatgaat tcatccagga tattattcga     1260

atcgttggct ctgaaaatgt tgaagtcatt agctcgaagg accagattgt tgacggttct     1320

tatatgaaac ctacgcacac gcacgatccc catcatgtca tggaccagga ctacttcctt     1380

gcctcagcaa ttgttgctcc tcgcaatgtc gccgatgtgc agtcgattgt cggacttgcc     1440

aataagttct catttcccct ctggcccatc tctattggaa gaaattccgg atatggcggt     1500

gctgcgccac gggttagtgg cagtgtcgtg ctggacatgg gaaagaatat gaacagagtt     1560

ctagaagtga acgtggaagg cgcatattgc gtggtggagc ccggtgtaac ttaccacgac     1620

ttgcataatt accttgaggc gaacaatctt cgagacaaat tatggcttga tgtaccggat     1680

cttggtggcg gttctgttct cggcaatgcc gttgagagag gtgtgggcta tacgccttac     1740

ggagatcatt ggatgatgca cagtgggatg gaagtcgtcc ttgcgaatgg cgagcttctt     1800

aggactggca tgggggctct acctgatcct aaacgtcccg aaacgatggg gctaaagcca     1860

gaagaccagc catggagcaa aatcgctcat ctgtttcctt atggcttcgg tccctatata     1920

gatgggctat tcagccaatc gaatatggga attgttacca agatcgggat ctggttaatg     1980

cccaatccag ggggttatca atcctacttg atcacactac ccaaagatgg tgatttaaaa     2040

caagccgtcg atattattcg tccccttcgt ctaggcatgg cccttcaaaa tgttcccact     2100

attcgccaca ttcttttgga tgcagcggtg ctcggtgaca agcgatctta ttcatccaag     2160

accgaacccc tctccgacga ggaattagac aagatcgcga aacagctcaa cttgggacga     2220

tggaactttt acggggcgct ctatggacct gagccgattc gaagggttct ctgggaaacg     2280

attaaagacg cattctcggc gatcccaggc gtcaagtttt attttccgga ggacactcct     2340

gaaaactccg ttctccgcgt gcgtgataag actatgcaag gcattccaac ttacgacgag     2400

ctaaagtgga tcgattggct ccctaatggt gcgcatctgt tcttctctcc tattgcgaag     2460

gtatctggtg aagatgcaat gatgcaatac gcagtcacca agaaaaggtg tcaggaggct     2520

gggttagatt ttatcggcac tttcacagtc ggtatgagag agatgcatca tatcgtttgt     2580

attgtgttca acaagaagga cctaatacaa aagagaaaag tacagtggct gatgagaacc     2640

cttattgatg actgtgctgc aaatggatgg ggcgaatatc gaacccatct ggccttcatg     2700

gaccaaatta tggaaaccta caactggaac aacagcagct tcctaaggtt caatgaggtc     2760

ctcaagaatg cggtggatcc taatggcatc attgccccgg gaaagtctgg tgtttggccg     2820

agtcaataca gtcatgttac ttggaaactg gaaagagatg actgtcctgc caagggtggg     2880

cgcgccgacc cagctttctt gtacaaagtg gtgatgtacc tcgagcacca ccaccaccac     2940

cact                                                                  2944


<210>  2
<211>  981
<212>  PRT
<213>  Chimeric

<400>  2

Met Gly Thr Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly 
1               5                   10                  15      


Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys 
            20                  25                  30          


Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu 
        35                  40                  45              


Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe 
    50                  55                  60                  


Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala 
65                  70                  75                  80  


Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr 
                85                  90                  95      


Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala 
            100                 105                 110         


Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro 
        115                 120                 125             


Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala 
    130                 135                 140                 


Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr 
145                 150                 155                 160 


Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn 
                165                 170                 175     


Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys 
            180                 185                 190         


Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn 
        195                 200                 205             


Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu 
    210                 215                 220                 


Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr 
225                 230                 235                 240 


Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln 
                245                 250                 255     


Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala 
            260                 265                 270         


Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu 
        275                 280                 285             


Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala 
    290                 295                 300                 


Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile 
305                 310                 315                 320 


Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile 
                325                 330                 335     


Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn 
            340                 345                 350         


Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln 
        355                 360                 365             


Thr Gly Thr Gly Ser Tyr Ile Thr Ser Leu Tyr Lys Lys Ala Gly Ser 
    370                 375                 380                 


Ala Ala Ala Pro Phe Thr Met Ser Lys Thr Gln Glu Phe Arg Pro Leu 
385                 390                 395                 400 


Thr Leu Pro Pro Lys Leu Ser Leu Ser Asp Phe Asn Glu Phe Ile Gln 
                405                 410                 415     


Asp Ile Ile Arg Ile Val Gly Ser Glu Asn Val Glu Val Ile Ser Ser 
            420                 425                 430         


Lys Asp Gln Ile Val Asp Gly Ser Tyr Met Lys Pro Thr His Thr His 
        435                 440                 445             


Asp Pro His His Val Met Asp Gln Asp Tyr Phe Leu Ala Ser Ala Ile 
    450                 455                 460                 


Val Ala Pro Arg Asn Val Ala Asp Val Gln Ser Ile Val Gly Leu Ala 
465                 470                 475                 480 


Asn Lys Phe Ser Phe Pro Leu Trp Pro Ile Ser Ile Gly Arg Asn Ser 
                485                 490                 495     


Gly Tyr Gly Gly Ala Ala Pro Arg Val Ser Gly Ser Val Val Leu Asp 
            500                 505                 510         


Met Gly Lys Asn Met Asn Arg Val Leu Glu Val Asn Val Glu Gly Ala 
        515                 520                 525             


Tyr Cys Val Val Glu Pro Gly Val Thr Tyr His Asp Leu His Asn Tyr 
    530                 535                 540                 


Leu Glu Ala Asn Asn Leu Arg Asp Lys Leu Trp Leu Asp Val Pro Asp 
545                 550                 555                 560 


Leu Gly Gly Gly Ser Val Leu Gly Asn Ala Val Glu Arg Gly Val Gly 
                565                 570                 575     


Tyr Thr Pro Tyr Gly Asp His Trp Met Met His Ser Gly Met Glu Val 
            580                 585                 590         


Val Leu Ala Asn Gly Glu Leu Leu Arg Thr Gly Met Gly Ala Leu Pro 
        595                 600                 605             


Asp Pro Lys Arg Pro Glu Thr Met Gly Leu Lys Pro Glu Asp Gln Pro 
    610                 615                 620                 


Trp Ser Lys Ile Ala His Leu Phe Pro Tyr Gly Phe Gly Pro Tyr Ile 
625                 630                 635                 640 


Asp Gly Leu Phe Ser Gln Ser Asn Met Gly Ile Val Thr Lys Ile Gly 
                645                 650                 655     


Ile Trp Leu Met Pro Asn Pro Gly Gly Tyr Gln Ser Tyr Leu Ile Thr 
            660                 665                 670         


Leu Pro Lys Asp Gly Asp Leu Lys Gln Ala Val Asp Ile Ile Arg Pro 
        675                 680                 685             


Leu Arg Leu Gly Met Ala Leu Gln Asn Val Pro Thr Ile Arg His Ile 
    690                 695                 700                 


Leu Leu Asp Ala Ala Val Leu Gly Asp Lys Arg Ser Tyr Ser Ser Lys 
705                 710                 715                 720 


Thr Glu Pro Leu Ser Asp Glu Glu Leu Asp Lys Ile Ala Lys Gln Leu 
                725                 730                 735     


Asn Leu Gly Arg Trp Asn Phe Tyr Gly Ala Leu Tyr Gly Pro Glu Pro 
            740                 745                 750         


Ile Arg Arg Val Leu Trp Glu Thr Ile Lys Asp Ala Phe Ser Ala Ile 
        755                 760                 765             


Pro Gly Val Lys Phe Tyr Phe Pro Glu Asp Thr Pro Glu Asn Ser Val 
    770                 775                 780                 


Leu Arg Val Arg Asp Lys Thr Met Gln Gly Ile Pro Thr Tyr Asp Glu 
785                 790                 795                 800 


Leu Lys Trp Ile Asp Trp Leu Pro Asn Gly Ala His Leu Phe Phe Ser 
                805                 810                 815     


Pro Ile Ala Lys Val Ser Gly Glu Asp Ala Met Met Gln Tyr Ala Val 
            820                 825                 830         


Thr Lys Lys Arg Cys Gln Glu Ala Gly Leu Asp Phe Ile Gly Thr Phe 
        835                 840                 845             


Thr Val Gly Met Arg Glu Met His His Ile Val Cys Ile Val Phe Asn 
    850                 855                 860                 


Lys Lys Asp Leu Ile Gln Lys Arg Lys Val Gln Trp Leu Met Arg Thr 
865                 870                 875                 880 


Leu Ile Asp Asp Cys Ala Ala Asn Gly Trp Gly Glu Tyr Arg Thr His 
                885                 890                 895     


Leu Ala Phe Met Asp Gln Ile Met Glu Thr Tyr Asn Trp Asn Asn Ser 
            900                 905                 910         


Ser Phe Leu Arg Phe Asn Glu Val Leu Lys Asn Ala Val Asp Pro Asn 
        915                 920                 925             


Gly Ile Ile Ala Pro Gly Lys Ser Gly Val Trp Pro Ser Gln Tyr Ser 
    930                 935                 940                 


His Val Thr Trp Lys Leu Glu Arg Asp Asp Cys Pro Ala Lys Gly Gly 
945                 950                 955                 960 


Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val Met Tyr Leu Glu His 
                965                 970                 975     


His His His His His 
            980     


