                         SEQUENCE LISTING

<110>  KeMyth Biotech Co., Ltd.
       CHONG, Pele Choi-Sing
 
<120>  TREATMENT OF DIABETES, TOLL-LIKE RECEPTOR 4 MODULATORS AND 
       METHODS FOR USING THE SAME

<130>  08936757WO

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/305,164
<151>  2016-03-08

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  2
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg 
        355                 


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Asn Gly Asp Leu Leu Leu Asp His Ser Gly Ala Tyr Val Ala Gln Tyr 
1               5                   10                  15      


Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val 
            20                  25                  30          


Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His 
        35                  40                  45              


Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val 
    50                  55                  60                  


Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val 
65                  70                  75                  80  


Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile 
                85                  90                  95      


Trp Gly Thr Thr Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
            100                 105                 110         


<210>  4
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
1               5                   10                  15      


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            20                  25                  30          


Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg 
        35                  40                  45              


Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val Glu 
    50                  55                  60                  


Asp Lys Val Glu Asn Asp 
65                  70  


<210>  5
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
1               5                   10                  15      


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            20                  25                  30          


Glu Trp Trp 
        35  


<210>  6
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
1               5                   10                  15      


Val Arg Asn Leu Ser Val Lys Ile Lys Glu Cys Thr Gly Leu Ala Trp 
            20                  25                  30          


Glu Trp Trp 
        35  


<210>  7
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
1               5                   10                  15      


Val Arg Asn Leu Ser Val Lys Leu Lys Glu Cys Thr Gly Leu Ala Trp 
            20                  25                  30          


Glu Trp Trp 
        35  


<210>  8
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
1               5                   10                  15      


Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr 
            20                  25                  30          


Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser 
        35                  40                  45              


Ile Trp 
    50  


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Gln Asp Leu Thr Ala 
1               5   


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
1               5                   10                  15      


Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp 
            20                  25                  30  


<210>  11
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Asn Gly Asp Leu Leu Leu Asp His Ser Gly Ala Tyr Val Ala Gln Tyr 
1               5                   10                  15      


Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val 
            20                  25                  30          


Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala 
        35                  40                  45          


<210>  12
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
1               5                   10                  15      


Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr 
            20                  25                  30          


Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser 
        35                  40                  45              


Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn 
    50                  55                  60                  


Asp 
65  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
1               5                   10                  15      


Val Lys Ile Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
1               5                   10                  15      


Val Lys Leu Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp 
            20                  25                  30  


<210>  15
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
ggaattccat atgaacggag atttactgct g                                      31


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
ccgctcgagg tcattttcta ccttatcttc tac                                    33


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Leu Glu His His His His His His 
1               5               



