                         SEQUENCE LISTING

<110>  NGM Biopharmaceuticals, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING BODY WEIGHT

<130>  13370-052-228

<140>  To Be Assigned
<141>  Herewith

<150>  62/304,141
<151>  2016-03-04

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  375
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human GFRAL polypeptide

<400>  1

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
    290                 295                 300                 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
305                 310                 315                 320 


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr Ala 
                325                 330                 335     


Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met Val 
            340                 345                 350         


Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser Ser 
        355                 360                 365             


Ile Gln Ile Pro Gly Glu Leu 
    370                 375 


<210>  2
<211>  332
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD

<400>  2

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
    290                 295                 300                 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
305                 310                 315                 320 


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
                325                 330         


<210>  3
<211>  1049
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human RET9

<400>  3

Lys Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys 
1               5                   10                  15      


Leu Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala 
            20                  25                  30          


Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His 
        35                  40                  45              


Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys 
    50                  55                  60                  


Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His 
65                  70                  75                  80  


Ser Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu 
                85                  90                  95      


Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly 
            100                 105                 110         


Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn 
        115                 120                 125             


Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe 
    130                 135                 140                 


Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly 
145                 150                 155                 160 


Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn 
                165                 170                 175     


Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg 
            180                 185                 190         


Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg 
        195                 200                 205             


Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala 
    210                 215                 220                 


Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr 
225                 230                 235                 240 


Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala 
                245                 250                 255     


Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr 
            260                 265                 270         


Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val 
        275                 280                 285             


Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln 
    290                 295                 300                 


Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn 
305                 310                 315                 320 


Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn 
                325                 330                 335     


Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu 
            340                 345                 350         


Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu 
        355                 360                 365             


His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr 
    370                 375                 380                 


Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly 
385                 390                 395                 400 


Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln 
                405                 410                 415     


Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val 
            420                 425                 430         


Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys 
        435                 440                 445             


Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala 
    450                 455                 460                 


Thr Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr 
465                 470                 475                 480 


Val Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys 
                485                 490                 495     


Ala Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly 
            500                 505                 510         


Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile 
        515                 520                 525             


Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp 
    530                 535                 540                 


Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln 
545                 550                 555                 560 


Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro 
                565                 570                 575     


Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu 
            580                 585                 590         


Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp 
        595                 600                 605             


Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe Ile 
    610                 615                 620                 


Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr His Lys Phe 
625                 630                 635                 640 


Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg Arg Pro 
                645                 650                 655     


Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro 
            660                 665                 670         


Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys Ile 
        675                 680                 685             


Leu Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly 
    690                 695                 700                 


Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala 
705                 710                 715                 720 


Phe His Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met 
                725                 730                 735     


Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu 
            740                 745                 750         


Phe Asn Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr 
        755                 760                 765             


Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala 
    770                 775                 780                 


Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly 
785                 790                 795                 800 


Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp 
                805                 810                 815     


His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala 
            820                 825                 830         


Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val 
        835                 840                 845             


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys 
    850                 855                 860                 


Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp 
865                 870                 875                 880 


Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala 
                885                 890                 895     


Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp 
            900                 905                 910         


Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro 
        915                 920                 925             


Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly 
    930                 935                 940                 


His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu 
945                 950                 955                 960 


Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala 
                965                 970                 975     


Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr 
            980                 985                 990         


Leu Asp Leu Ala Ala Ser Thr Pro  Ser Asp Ser Leu Ile  Tyr Asp Asp 
        995                 1000                 1005             


Gly Leu  Ser Glu Glu Glu Thr  Pro Leu Val Asp Cys  Asn Asn Ala 
    1010                 1015                 1020             


Pro Leu  Pro Arg Ala Leu Pro  Ser Thr Trp Ile Glu  Asn Lys Leu 
    1025                 1030                 1035             


Tyr Gly  Arg Ile Ser His Ala  Phe Thr Arg Phe 
    1040                 1045                 


<210>  4
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRAL ECD fragment

<400>  4

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350     


<210>  5
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRAL ECD

<400>  5

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
    290                 295                 300                 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
305                 310                 315                 320 


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
                325                 330         


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human GDF15 polypeptide 

<400>  6

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  7
<211>  367
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Fc-hGDF15 protein sequence 

<400>  7

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                245                 250                 255     


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
            260                 265                 270         


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
        275                 280                 285             


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
    290                 295                 300                 


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
305                 310                 315                 320 


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
                325                 330                 335     


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
            340                 345                 350         


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
        355                 360                 365         


<210>  8
<211>  274
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Fc protein sequence

<400>  8

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Thr Val Asp 
225                 230                 235                 240 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                245                 250                 255     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            260                 265                 270         


Gly Lys 
        


<210>  9
<211>  394
<212>  PRT
<213>  Homo sapiens

<220>
<223>  full-length precursor human GFRAL with signal peptide sequence

<400>  9

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  10
<211>  393
<212>  PRT
<213>  Mus musculus

<220>
<223>  Mouse GFRAL protein sequence

<400>  10

Met Leu Val Phe Ile Phe Leu Ala Val Thr Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu 
            20                  25                  30          


Ile Asp Ala Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr 
        35                  40                  45              


Cys Leu Thr Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu 
65                  70                  75                  80  


Cys Leu Cys Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp 
            100                 105                 110         


Lys Trp Asn Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met 
        115                 120                 125             


Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Glu Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu 
                245                 250                 255     


Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Glu Ser Cys Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln 
        275                 280                 285             


Val Pro Cys Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys 
    290                 295                 300                 


Met Ile Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys 
                325                 330                 335     


Glu Ile Thr Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Glu Leu Leu 
            340                 345                 350         


Tyr Val Val Val Cys Met Ala Val Thr Cys Gly Ile Leu Phe Leu Val 
        355                 360                 365             


Met Leu Lys Leu Arg Ile Gln Ser Glu Lys Arg Asp Pro Ser Ser Ile 
    370                 375                 380                 


Glu Ile Ala Gly Gly Val Ile Ile Gln 
385                 390             


<210>  11
<211>  394
<212>  PRT
<213>  Rattus norvegicus

<220>
<223>  Rat GFRAL protein sequence

<400>  11

Met Leu Val Phe Ile Phe Leu Ala Val Arg Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala Tyr Phe Met Arg Gln Cys Leu 
            20                  25                  30          


Thr Asp Thr Asp Gly Cys Lys Gln Ser Trp Arg Ser Met Glu Asp Ala 
        35                  40                  45              


Cys Leu Val Ser Gly Asp Ser Cys Lys Ile Asn Asn Pro Leu Pro Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ser Leu Val Glu Lys His Phe Gln Phe Lys Gly 
65                  70                  75                  80  


Cys Leu Cys Thr Asp Asp Leu His Cys Thr Val Asn Lys Ile Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Ser Met Lys Lys Asp Asn Lys Tyr 
            100                 105                 110         


Lys Arg Asn Leu Thr Thr Pro Leu Tyr His Asp Thr Gly Phe Lys Gln 
        115                 120                 125             


Met Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Thr Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Val Val Pro Pro Pro Thr Cys Leu Ser Val 
    210                 215                 220                 


Ile His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr Tyr Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Thr Glu Cys Trp Pro His Val Ala Gly Lys Cys Arg Glu Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Ser Cys Arg Ala Ala Tyr Leu Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Pro Cys Ala Cys Arg Ser Ile Thr Gln Gly Glu Glu Pro Leu 
    290                 295                 300                 


Cys Met Ala Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Arg Lys His Ser 
                325                 330                 335     


Lys Glu Ile Thr Leu Thr Gly Phe Asn Ser Pro Phe Ser Gly Glu Leu 
            340                 345                 350         


Ile Tyr Val Val Val Cys Met Val Val Thr Ser Gly Ile Leu Ser Leu 
        355                 360                 365             


Val Met Leu Lys Leu Arg Ile Pro Ser Lys Lys Arg Asp Pro Ala Pro 
    370                 375                 380                 


Ile Glu Ile Ala Gly Ala Val Ile Ile Gln 
385                 390                 


<210>  12
<211>  394
<212>  PRT
<213>  Cynomolgus monkey

<220>
<223>  Cynomolgus monkey GFRAL protein sequence

<400>  12

Phe Val Val Val Val Ile Gln Ala Leu Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


His Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Leu Ser Gln Val Pro Gly Glu Leu 
385                 390                 


<210>  13
<211>  1114
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human RET51 protein sequence

<400>  13

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  14
<211>  1072
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human RET9 protein sequence

<400>  14

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  15
<211>  1115
<212>  PRT
<213>  Mus musculus

<220>
<223>  Mouse RET51 protein sequence

<400>  15

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Gly Leu Lys Leu Ile 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Glu Ala Pro Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Val Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asp Trp Ile Arg Ile Asn Glu Thr Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg 
            100                 105                 110         


Asn Gly Gly Phe Pro Leu Leu Thr Ile Phe Leu Gln Val Phe Leu Gly 
        115                 120                 125             


Ser Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Thr Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe 
145                 150                 155                 160 


Lys Ala Gln Asp Leu Cys Ile Pro Glu Thr Ala Val Ser Phe Arg Val 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe Tyr His Phe His Met Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Ser Leu Leu Gly 
        195                 200                 205             


Gly Asp Ser Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Leu Arg Glu Lys Tyr Val Leu Glu 
225                 230                 235                 240 


Ala Leu Cys Ile Val Ala Gly Pro Gly Ala Asn Lys Glu Thr Val Thr 
                245                 250                 255     


Leu Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr 
            260                 265                 270         


Phe Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg 
        275                 280                 285             


Lys Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val 
    290                 295                 300                 


Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Asn Thr Leu Leu 
305                 310                 315                 320 


Ser Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Ser Pro 
                325                 330                 335     


Ile Glu Thr Leu Val Gln Val Asn Asn Asn Ser Val Arg Ala Thr Met 
            340                 345                 350         


His Asn Tyr Lys Leu Ile Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser 
        355                 360                 365             


Arg Val Leu Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly 
    370                 375                 380                 


Pro Gly Ala Gly Gly Ile Leu Val Leu His Phe Asn Val Ser Val Leu 
385                 390                 395                 400 


Pro Val Thr Leu Asn Leu Pro Arg Ala Tyr Ser Phe Pro Val Asn Lys 
                405                 410                 415     


Arg Ala Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys 
            420                 425                 430         


Gln Glu Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser 
        435                 440                 445             


Ile Asn Cys Thr Ala Leu Gly Val Val Thr Ser Pro Glu Asp Thr Ser 
    450                 455                 460                 


Gly Thr Leu Phe Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys 
465                 470                 475                 480 


Thr Lys Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg 
                485                 490                 495     


Gln Thr Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Ser Ile Thr 
            500                 505                 510         


Glu Glu Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro 
        515                 520                 525             


Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu 
    530                 535                 540                 


Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys 
545                 550                 555                 560 


Ser Pro Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Val Glu 
                565                 570                 575     


Ser Arg Asp Ala Asn Ile Cys Pro Gln Asp Cys Leu Arg Ala Asp Ile 
            580                 585                 590         


Val Gly Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr 
        595                 600                 605             


Gly Ile Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro 
    610                 615                 620                 


Glu Asp Ser Gln Gly Pro Leu Cys Asp Ala Leu Cys Arg Thr Ile Ile 
625                 630                 635                 640 


Thr Ala Ala Leu Phe Ser Leu Ile Ile Ser Ile Leu Leu Ser Ile Phe 
                645                 650                 655     


Cys Val Cys His His His Lys His Gly His Lys Pro Pro Ile Ala Ser 
            660                 665                 670         


Ala Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr 
        675                 680                 685             


Ser Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Thr Glu Asn Gln 
    690                 695                 700                 


Val Pro Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe 
705                 710                 715                 720 


Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
                725                 730                 735     


Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly 
            740                 745                 750         


Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser 
        755                 760                 765             


Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn 
    770                 775                 780                 


His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro 
785                 790                 795                 800 


Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe 
                805                 810                 815     


Leu Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Gly Gly Gly 
            820                 825                 830         


Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr 
        835                 840                 845             


Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln 
    850                 855                 860                 


Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn 
865                 870                 875                 880 


Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu 
                885                 890                 895     


Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly 
            900                 905                 910         


Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile 
        915                 920                 925             


Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
    930                 935                 940                 


Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg 
945                 950                 955                 960 


Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn 
                965                 970                 975     


Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu 
            980                 985                 990         


Pro Asp Lys Arg Pro Val Phe Ala  Asp Ile Ser Lys Asp  Leu Glu Lys 
        995                 1000                 1005             


Met Met  Val Lys Ser Arg Asp  Tyr Leu Asp Leu Ala  Ala Ser Thr 
    1010                 1015                 1020             


Pro Ser  Asp Ser Leu Leu Tyr  Asp Asp Gly Leu Ser  Glu Glu Glu 
    1025                 1030                 1035             


Thr Pro  Leu Val Asp Cys Asn  Asn Ala Pro Leu Pro  Arg Ser Leu 
    1040                 1045                 1050             


Pro Ser  Thr Trp Ile Glu Asn  Lys Leu Tyr Gly Met  Ser Asp Pro 
    1055                 1060                 1065             


Asn Trp  Pro Gly Glu Ser Pro  Val Pro Leu Thr Arg  Ala Asp Gly 
    1070                 1075                 1080             


Thr Ser  Thr Gly Phe Pro Arg  Tyr Ala Asn Asp Ser  Val Tyr Ala 
    1085                 1090                 1095             


Asn Trp  Met Val Ser Pro Ser  Ala Ala Lys Leu Met  Asp Thr Phe 
    1100                 1105                 1110             


Asp Ser  
    1115 


<210>  16
<211>  1073
<212>  PRT
<213>  Mus musculus

<220>
<223>  Mouse RET9 protein sequence

<400>  16

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Gly Leu Lys Leu Ile 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Glu Ala Pro Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Val Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asp Trp Ile Arg Ile Asn Glu Thr Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg 
            100                 105                 110         


Asn Gly Gly Phe Pro Leu Leu Thr Ile Phe Leu Gln Val Phe Leu Gly 
        115                 120                 125             


Ser Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Thr Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe 
145                 150                 155                 160 


Lys Ala Gln Asp Leu Cys Ile Pro Glu Thr Ala Val Ser Phe Arg Val 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe Tyr His Phe His Met Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Ser Leu Leu Gly 
        195                 200                 205             


Gly Asp Ser Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Leu Arg Glu Lys Tyr Val Leu Glu 
225                 230                 235                 240 


Ala Leu Cys Ile Val Ala Gly Pro Gly Ala Asn Lys Glu Thr Val Thr 
                245                 250                 255     


Leu Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr 
            260                 265                 270         


Phe Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg 
        275                 280                 285             


Lys Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val 
    290                 295                 300                 


Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Asn Thr Leu Leu 
305                 310                 315                 320 


Ser Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Ser Pro 
                325                 330                 335     


Ile Glu Thr Leu Val Gln Val Asn Asn Asn Ser Val Arg Ala Thr Met 
            340                 345                 350         


His Asn Tyr Lys Leu Ile Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser 
        355                 360                 365             


Arg Val Leu Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly 
    370                 375                 380                 


Pro Gly Ala Gly Gly Ile Leu Val Leu His Phe Asn Val Ser Val Leu 
385                 390                 395                 400 


Pro Val Thr Leu Asn Leu Pro Arg Ala Tyr Ser Phe Pro Val Asn Lys 
                405                 410                 415     


Arg Ala Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys 
            420                 425                 430         


Gln Glu Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser 
        435                 440                 445             


Ile Asn Cys Thr Ala Leu Gly Val Val Thr Ser Pro Glu Asp Thr Ser 
    450                 455                 460                 


Gly Thr Leu Phe Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys 
465                 470                 475                 480 


Thr Lys Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg 
                485                 490                 495     


Gln Thr Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Ser Ile Thr 
            500                 505                 510         


Glu Glu Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro 
        515                 520                 525             


Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu 
    530                 535                 540                 


Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys 
545                 550                 555                 560 


Ser Pro Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Val Glu 
                565                 570                 575     


Ser Arg Asp Ala Asn Ile Cys Pro Gln Asp Cys Leu Arg Ala Asp Ile 
            580                 585                 590         


Val Gly Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr 
        595                 600                 605             


Gly Ile Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro 
    610                 615                 620                 


Glu Asp Ser Gln Gly Pro Leu Cys Asp Ala Leu Cys Arg Thr Ile Ile 
625                 630                 635                 640 


Thr Ala Ala Leu Phe Ser Leu Ile Ile Ser Ile Leu Leu Ser Ile Phe 
                645                 650                 655     


Cys Val Cys His His His Lys His Gly His Lys Pro Pro Ile Ala Ser 
            660                 665                 670         


Ala Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr 
        675                 680                 685             


Ser Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Thr Glu Asn Gln 
    690                 695                 700                 


Val Pro Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe 
705                 710                 715                 720 


Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
                725                 730                 735     


Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly 
            740                 745                 750         


Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser 
        755                 760                 765             


Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn 
    770                 775                 780                 


His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro 
785                 790                 795                 800 


Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe 
                805                 810                 815     


Leu Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Gly Gly Gly 
            820                 825                 830         


Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr 
        835                 840                 845             


Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln 
    850                 855                 860                 


Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn 
865                 870                 875                 880 


Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu 
                885                 890                 895     


Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly 
            900                 905                 910         


Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile 
        915                 920                 925             


Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
    930                 935                 940                 


Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg 
945                 950                 955                 960 


Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn 
                965                 970                 975     


Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu 
            980                 985                 990         


Pro Asp Lys Arg Pro Val Phe Ala  Asp Ile Ser Lys Asp  Leu Glu Lys 
        995                 1000                 1005             


Met Met  Val Lys Ser Arg Asp  Tyr Leu Asp Leu Ala  Ala Ser Thr 
    1010                 1015                 1020             


Pro Ser  Asp Ser Leu Leu Tyr  Asp Asp Gly Leu Ser  Glu Glu Glu 
    1025                 1030                 1035             


Thr Pro  Leu Val Asp Cys Asn  Asn Ala Pro Leu Pro  Arg Ser Leu 
    1040                 1045                 1050             


Pro Ser  Thr Trp Ile Glu Asn  Lys Leu Tyr Gly Arg  Ile Ser His 
    1055                 1060                 1065             


Ala Phe  Thr Arg Phe 
    1070             


<210>  17
<211>  1114
<212>  PRT
<213>  Rattus norvegicus

<220>
<223>  IgK signal peptide-Rat RET51 protein sequence

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Ala Pro Leu Gly Leu Tyr Phe Ser Arg 
            20                  25                  30          


Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr Pro 
        35                  40                  45              


Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro Ser 
    50                  55                  60                  


Phe Arg Leu Gly Gln Tyr Leu Tyr Gly Val Tyr Arg Thr Arg Leu His 
65                  70                  75                  80  


Glu Asn Asp Trp Ile His Ile Asp Ser Gly Thr Gly Leu Leu Tyr Leu 
                85                  90                  95      


Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg Asn 
            100                 105                 110         


Gly Gly Phe Pro Leu Leu Thr Val Phe Leu Gln Val Phe Leu Gly Ser 
        115                 120                 125             


Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Ala Arg Val 
    130                 135                 140                 


Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe Lys 
145                 150                 155                 160 


Ala Arg Asp Leu Cys Thr Pro Glu Thr Gly Val Ser Phe Arg Ile Arg 
                165                 170                 175     


Glu Asn Arg Pro Pro Gly Thr Phe Tyr Gln Phe Arg Met Leu Pro Val 
            180                 185                 190         


Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Lys Leu Leu Glu Gly 
        195                 200                 205             


Asp Gly Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser Thr 
    210                 215                 220                 


Arg Trp Ala Leu Asp Arg Glu Leu Gln Glu Lys Tyr Val Leu Glu Ala 
225                 230                 235                 240 


Glu Cys Ala Val Ala Gly Pro Gly Ala Asn Lys Glu Lys Val Ala Val 
                245                 250                 255     


Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Pro Pro Thr Phe 
            260                 265                 270         


Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Ser 
305                 310                 315                 320 


Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Thr Pro Asn 
                325                 330                 335     


Glu Thr Leu Val Gln Ser Asn Asn Asn Ser Val Arg Ala Thr Met His 
            340                 345                 350         


Asn Tyr Lys Leu Val Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser Arg 
        355                 360                 365             


Val Leu Gln Leu Val Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ser Gly Val Leu Phe Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Thr Leu Asn Leu Pro Met Ala Tyr Ser Phe Pro Val Asn Arg Arg Ala 
                405                 410                 415     


Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Glu 
            420                 425                 430         


Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser Thr Asn 
        435                 440                 445             


Cys Ser Ala Leu Gly Val Val Thr Ser Thr Glu Asp Thr Ser Gly Thr 
    450                 455                 460                 


Leu Tyr Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys Thr Glu 
465                 470                 475                 480 


Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg Gln Thr 
                485                 490                 495     


Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Tyr Ile Ala Glu Glu 
            500                 505                 510         


Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Leu Glu Ser Arg 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Pro Ile Val Gly 
            580                 585                 590         


Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr Gly Ile 
        595                 600                 605             


Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ser Gln Gly Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Thr Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Ile Ser Val Leu Leu Ser Thr Phe Cys 
                645                 650                 655     


Ile His Arg Tyr His Lys His Ala His Lys Pro Pro Ile Ala Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Ser Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Leu Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Ser  Ala Pro Leu Pro Arg  Ser Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Ser Thr  Gly Phe Pro Arg Tyr  Ala Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Val Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  18
<211>  1072
<212>  PRT
<213>  Rattus norvegicus

<220>
<223>  IgK signal peptide-Rat RET9 protein sequence 

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Ala Pro Leu Gly Leu Tyr Phe Ser Arg 
            20                  25                  30          


Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr Pro 
        35                  40                  45              


Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro Ser 
    50                  55                  60                  


Phe Arg Leu Gly Gln Tyr Leu Tyr Gly Val Tyr Arg Thr Arg Leu His 
65                  70                  75                  80  


Glu Asn Asp Trp Ile His Ile Asp Ser Gly Thr Gly Leu Leu Tyr Leu 
                85                  90                  95      


Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg Asn 
            100                 105                 110         


Gly Gly Phe Pro Leu Leu Thr Val Phe Leu Gln Val Phe Leu Gly Ser 
        115                 120                 125             


Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Ala Arg Val 
    130                 135                 140                 


Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe Lys 
145                 150                 155                 160 


Ala Arg Asp Leu Cys Thr Pro Glu Thr Gly Val Ser Phe Arg Ile Arg 
                165                 170                 175     


Glu Asn Arg Pro Pro Gly Thr Phe Tyr Gln Phe Arg Met Leu Pro Val 
            180                 185                 190         


Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Lys Leu Leu Glu Gly 
        195                 200                 205             


Asp Gly Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser Thr 
    210                 215                 220                 


Arg Trp Ala Leu Asp Arg Glu Leu Gln Glu Lys Tyr Val Leu Glu Ala 
225                 230                 235                 240 


Glu Cys Ala Val Ala Gly Pro Gly Ala Asn Lys Glu Lys Val Ala Val 
                245                 250                 255     


Ser Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Pro Pro Thr Phe 
            260                 265                 270         


Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Ser 
305                 310                 315                 320 


Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Thr Pro Asn 
                325                 330                 335     


Glu Thr Leu Val Gln Ser Asn Asn Asn Ser Val Arg Ala Thr Met His 
            340                 345                 350         


Asn Tyr Lys Leu Val Leu Asn Arg Ser Leu Ser Ile Ser Glu Ser Arg 
        355                 360                 365             


Val Leu Gln Leu Val Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ser Gly Val Leu Phe Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Thr Leu Asn Leu Pro Met Ala Tyr Ser Phe Pro Val Asn Arg Arg Ala 
                405                 410                 415     


Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Glu 
            420                 425                 430         


Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser Thr Asn 
        435                 440                 445             


Cys Ser Ala Leu Gly Val Val Thr Ser Thr Glu Asp Thr Ser Gly Thr 
    450                 455                 460                 


Leu Tyr Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys Thr Glu 
465                 470                 475                 480 


Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg Gln Thr 
                485                 490                 495     


Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Tyr Ile Ala Glu Glu 
            500                 505                 510         


Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Leu Glu Ser Arg 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Pro Ile Val Gly 
            580                 585                 590         


Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr Gly Ile 
        595                 600                 605             


Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ser Gln Gly Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Thr Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Ile Ser Val Leu Leu Ser Thr Phe Cys 
                645                 650                 655     


Ile His Arg Tyr His Lys His Ala His Lys Pro Pro Ile Ala Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Thr Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Lys Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Ser Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Leu Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Ser  Ala Pro Leu Pro Arg  Ser Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  19
<211>  1108
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  IgK signal peptide-Cynomolgus monkey RET51 protein sequence 

<400>  19

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu 
            20                  25                  30          


Lys Leu Tyr Val Asp Gln Pro Ala Gly Thr Pro Leu Leu Tyr Val His 
        35                  40                  45              


Ala Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln 
    50                  55                  60                  


His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile 
65                  70                  75                  80  


Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp 
                85                  90                  95      


Arg Ser Ser Trp Glu Lys Leu Ser Gly Arg Asn Arg Gly Phe Pro Leu 
            100                 105                 110         


Leu Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu 
        115                 120                 125             


Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe 
    130                 135                 140                 


Asn Thr Ser Phe Pro Ala Cys Thr Ser Leu Lys Pro Arg Glu Leu Cys 
145                 150                 155                 160 


Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro 
                165                 170                 175     


Gly Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro 
            180                 185                 190         


Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe 
        195                 200                 205             


Arg Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp 
    210                 215                 220                 


Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His 
225                 230                 235                 240 


Ala Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val 
                245                 250                 255     


Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr 
            260                 265                 270         


Ala Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala 
        275                 280                 285             


Thr Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu 
    290                 295                 300                 


Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Thr Gln 
305                 310                 315                 320 


Gln Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala 
                325                 330                 335     


Asn Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu 
            340                 345                 350         


Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val 
        355                 360                 365             


Leu Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu 
    370                 375                 380                 


Leu His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser 
385                 390                 395                 400 


Ser Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile 
                405                 410                 415     


Gly Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val 
            420                 425                 430         


Gln Tyr Glu Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val 
        435                 440                 445             


Val Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr 
    450                 455                 460                 


Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val 
465                 470                 475                 480 


Ala Thr Asn His Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val 
                485                 490                 495     


Thr Val Glu Gly Leu Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser 
            500                 505                 510         


Cys Ala Val Ser Lys Arg Arg Pro Glu Cys Glu Glu Cys Gly Gly Leu 
        515                 520                 525             


Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly 
    530                 535                 540                 


Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro 
545                 550                 555                 560 


Asp Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro 
                565                 570                 575     


Gln Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu 
            580                 585                 590         


Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu 
        595                 600                 605             


Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys 
    610                 615                 620                 


Asp Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe 
625                 630                 635                 640 


Ile Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Arg Tyr His Lys 
                645                 650                 655     


Phe Ala His Lys Pro Pro Ile Pro Ser Ala Glu Met Thr Phe Arg Arg 
            660                 665                 670         


Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg 
        675                 680                 685             


Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys 
    690                 695                 700                 


Ile Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu 
705                 710                 715                 720 


Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr 
                725                 730                 735     


Ala Phe Arg Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys 
            740                 745                 750         


Met Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser 
        755                 760                 765             


Glu Phe Asn Leu Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu 
    770                 775                 780                 


Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr 
785                 790                 795                 800 


Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val 
                805                 810                 815     


Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu 
            820                 825                 830         


Asp His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe 
        835                 840                 845             


Ala Trp Gln Ile Ser Arg Gly Met Gln Tyr Leu Ala Glu Met Lys Leu 
    850                 855                 860                 


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg 
865                 870                 875                 880 


Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu 
                885                 890                 895     


Asp Ser Tyr Val Lys Arg Ser Lys Gly Arg Ile Pro Val Lys Trp Met 
            900                 905                 910         


Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val 
        915                 920                 925             


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn 
    930                 935                 940                 


Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr 
945                 950                 955                 960 


Gly His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg 
                965                 970                 975     


Leu Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe 
            980                 985                 990         


Ala Asp Ile Ser Lys Asp Leu Glu  Lys Met Met Val Lys  Ser Arg Asp 
        995                 1000                 1005             


Tyr Leu  Asp Leu Ala Ala Ser  Thr Pro Ser Asp Ser  Leu Leu Tyr 
    1010                 1015                 1020             


Asp Asp  Gly Leu Ser Glu Glu  Glu Thr Pro Leu Val  Asp Cys Asn 
    1025                 1030                 1035             


Asn Ala  Pro Leu Pro Arg Ala  Leu Pro Ser Thr Trp  Ile Glu Asn 
    1040                 1045                 1050             


Lys Leu  Tyr Gly Met Ser Asp  Pro Asn Trp Pro Gly  Glu Ser Pro 
    1055                 1060                 1065             


Val Pro  Leu Thr Arg Ala Asp  Gly Thr Asn Thr Gly  Phe Pro Arg 
    1070                 1075                 1080             


Tyr Ala  Asn Asp Ser Val Tyr  Ala Asn Trp Met Leu  Ser Pro Ser 
    1085                 1090                 1095             


Ala Ala  Lys Leu Met Asp Thr  Phe Asp Ser 
    1100                 1105             


<210>  20
<211>  1066
<212>  PRT
<213>  Cynomolgus monkey

<220>
<223>  Cynomolgus monkey IgK signal peptide-RET9 protein sequence

<400>  20

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu 
            20                  25                  30          


Lys Leu Tyr Val Asp Gln Pro Ala Gly Thr Pro Leu Leu Tyr Val His 
        35                  40                  45              


Ala Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln 
    50                  55                  60                  


His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile 
65                  70                  75                  80  


Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp 
                85                  90                  95      


Arg Ser Ser Trp Glu Lys Leu Ser Gly Arg Asn Arg Gly Phe Pro Leu 
            100                 105                 110         


Leu Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu 
        115                 120                 125             


Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe 
    130                 135                 140                 


Asn Thr Ser Phe Pro Ala Cys Thr Ser Leu Lys Pro Arg Glu Leu Cys 
145                 150                 155                 160 


Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro 
                165                 170                 175     


Gly Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro 
            180                 185                 190         


Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe 
        195                 200                 205             


Arg Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp 
    210                 215                 220                 


Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His 
225                 230                 235                 240 


Ala Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val 
                245                 250                 255     


Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr 
            260                 265                 270         


Ala Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala 
        275                 280                 285             


Thr Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu 
    290                 295                 300                 


Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Thr Gln 
305                 310                 315                 320 


Gln Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala 
                325                 330                 335     


Asn Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu 
            340                 345                 350         


Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val 
        355                 360                 365             


Leu Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu 
    370                 375                 380                 


Leu His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser 
385                 390                 395                 400 


Ser Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile 
                405                 410                 415     


Gly Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val 
            420                 425                 430         


Gln Tyr Glu Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val 
        435                 440                 445             


Val Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr 
    450                 455                 460                 


Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val 
465                 470                 475                 480 


Ala Thr Asn His Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val 
                485                 490                 495     


Thr Val Glu Gly Leu Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser 
            500                 505                 510         


Cys Ala Val Ser Lys Arg Arg Pro Glu Cys Glu Glu Cys Gly Gly Leu 
        515                 520                 525             


Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly 
    530                 535                 540                 


Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro 
545                 550                 555                 560 


Asp Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro 
                565                 570                 575     


Gln Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu 
            580                 585                 590         


Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu 
        595                 600                 605             


Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys 
    610                 615                 620                 


Asp Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe 
625                 630                 635                 640 


Ile Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Arg Tyr His Lys 
                645                 650                 655     


Phe Ala His Lys Pro Pro Ile Pro Ser Ala Glu Met Thr Phe Arg Arg 
            660                 665                 670         


Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg 
        675                 680                 685             


Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys 
    690                 695                 700                 


Ile Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu 
705                 710                 715                 720 


Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr 
                725                 730                 735     


Ala Phe Arg Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys 
            740                 745                 750         


Met Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser 
        755                 760                 765             


Glu Phe Asn Leu Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu 
    770                 775                 780                 


Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr 
785                 790                 795                 800 


Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val 
                805                 810                 815     


Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu 
            820                 825                 830         


Asp His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe 
        835                 840                 845             


Ala Trp Gln Ile Ser Arg Gly Met Gln Tyr Leu Ala Glu Met Lys Leu 
    850                 855                 860                 


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg 
865                 870                 875                 880 


Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu 
                885                 890                 895     


Asp Ser Tyr Val Lys Arg Ser Lys Gly Arg Ile Pro Val Lys Trp Met 
            900                 905                 910         


Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val 
        915                 920                 925             


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn 
    930                 935                 940                 


Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr 
945                 950                 955                 960 


Gly His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg 
                965                 970                 975     


Leu Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe 
            980                 985                 990         


Ala Asp Ile Ser Lys Asp Leu Glu  Lys Met Met Val Lys  Ser Arg Asp 
        995                 1000                 1005             


Tyr Leu  Asp Leu Ala Ala Ser  Thr Pro Ser Asp Ser  Leu Leu Tyr 
    1010                 1015                 1020             


Asp Asp  Gly Leu Ser Glu Glu  Glu Thr Pro Leu Val  Asp Cys Asn 
    1025                 1030                 1035             


Asn Ala  Pro Leu Pro Arg Ala  Leu Pro Ser Thr Trp  Ile Glu Asn 
    1040                 1045                 1050             


Lys Leu  Tyr Gly Arg Ile Ser  His Ala Phe Thr Arg  Phe 
    1055                 1060                 1065     


<210>  21
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gfral-Fc sequence

<400>  21

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu 
            20                  25                  30          


Gln Cys Leu Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met 
        35                  40                  45              


Glu Asp Ala Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg 
    50                  55                  60                  


Asn Ser Ser Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn 
65                  70                  75                  80  


Phe Gln Phe Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val 
                85                  90                  95      


Asn Lys Leu Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys 
            100                 105                 110         


Glu Asp Lys Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe 
        115                 120                 125             


Lys Gly Met Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp 
    130                 135                 140                 


Val Val Cys Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala 
145                 150                 155                 160 


Asn Gly Asn Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe 
                165                 170                 175     


Phe Tyr Gln Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys 
            180                 185                 190         


Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu 
        195                 200                 205             


His Ser Lys Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu 
    210                 215                 220                 


Ser Val Ile Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr 
225                 230                 235                 240 


Arg Thr Phe Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His 
                245                 250                 255     


Glu Asp Glu Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys 
            260                 265                 270         


Ser Gly Ser Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr 
        275                 280                 285             


Val Leu Gln Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu 
    290                 295                 300                 


Ser Leu Cys Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe 
305                 310                 315                 320 


Asn Tyr Pro Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg 
                325                 330                 335     


Lys His Ala Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn 
            340                 345                 350         


Gly Glu Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        355                 360                 365             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    370                 375                 380                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
385                 390                 395                 400 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                405                 410                 415     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            420                 425                 430         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        435                 440                 445             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    450                 455                 460                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
465                 470                 475                 480 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                485                 490                 495     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            500                 505                 510         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        515                 520                 525             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    530                 535                 540                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
545                 550                 555                 560 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                565                 570                 575     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585     


<210>  22
<211>  297
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD fragment

<400>  22

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys 
    290                 295         


<210>  23
<211>  237
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD fragment 

<400>  23

Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser 
1               5                   10                  15      


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
            20                  25                  30          


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
        35                  40                  45              


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
    50                  55                  60                  


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
65                  70                  75                  80  


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
                85                  90                  95      


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
            100                 105                 110         


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
        115                 120                 125             


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
    130                 135                 140                 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
145                 150                 155                 160 


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
                165                 170                 175     


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
            180                 185                 190         


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
        195                 200                 205             


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
    210                 215                 220                 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
225                 230                 235         


<210>  24
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA-hGDF15 protein sequence

<400>  24

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ala His Lys Ser Glu Val Ala His Arg 
            20                  25                  30          


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
        35                  40                  45              


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
    50                  55                  60                  


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
65                  70                  75                  80  


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
                85                  90                  95      


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
            100                 105                 110         


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
        115                 120                 125             


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
    130                 135                 140                 


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
145                 150                 155                 160 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
                165                 170                 175     


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
            180                 185                 190         


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
        195                 200                 205             


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
    210                 215                 220                 


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
225                 230                 235                 240 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
                245                 250                 255     


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
            260                 265                 270         


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
        275                 280                 285             


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
    290                 295                 300                 


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
305                 310                 315                 320 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
                325                 330                 335     


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
            340                 345                 350         


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
        355                 360                 365             


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
    370                 375                 380                 


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
385                 390                 395                 400 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
                405                 410                 415     


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
            420                 425                 430         


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
        435                 440                 445             


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
    450                 455                 460                 


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
465                 470                 475                 480 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
                485                 490                 495     


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
            500                 505                 510         


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
        515                 520                 525             


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
    530                 535                 540                 


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
545                 550                 555                 560 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
                565                 570                 575     


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
            580                 585                 590         


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Glu Gly Arg Ala Arg Asn 
    610                 615                 620                 


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
625                 630                 635                 640 


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
                645                 650                 655     


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
            660                 665                 670         


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
        675                 680                 685             


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
    690                 695                 700                 


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
705                 710                 715                 720 


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730             


<210>  25
<211>  308
<212>  PRT
<213>  Homo sapiens

<220>
<223>  precursor human GDF15 polypeptide 

<400>  25

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  26
<211>  1072
<212>  PRT
<213>  Homo sapiens

<220>
<223>  full-length precursor human RET protein 

<400>  26

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  27
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD

<400>  27

Lys Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys 
1               5                   10                  15      


Leu Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala 
            20                  25                  30          


Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His 
        35                  40                  45              


Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys 
    50                  55                  60                  


Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His 
65                  70                  75                  80  


Ser Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu 
                85                  90                  95      


Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly 
            100                 105                 110         


Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn 
        115                 120                 125             


Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe 
    130                 135                 140                 


Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly 
145                 150                 155                 160 


Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn 
                165                 170                 175     


Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg 
            180                 185                 190         


Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg 
        195                 200                 205             


Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala 
    210                 215                 220                 


Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr 
225                 230                 235                 240 


Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala 
                245                 250                 255     


Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr 
            260                 265                 270         


Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val 
        275                 280                 285             


Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln 
    290                 295                 300                 


Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn 
305                 310                 315                 320 


Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn 
                325                 330                 335     


Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu 
            340                 345                 350         


Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu 
        355                 360                 365             


His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr 
    370                 375                 380                 


Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly 
385                 390                 395                 400 


Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln 
                405                 410                 415     


Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val 
            420                 425                 430         


Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys 
        435                 440                 445             


Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala 
    450                 455                 460                 


Thr Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr 
465                 470                 475                 480 


Val Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys 
                485                 490                 495     


Ala Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly 
            500                 505                 510         


Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile 
        515                 520                 525             


Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp 
    530                 535                 540                 


Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln 
545                 550                 555                 560 


Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro 
                565                 570                 575     


Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu 
            580                 585                 590         


Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp 
        595                 600                 605             


Glu Leu Cys Arg 
    610         


<210>  28
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD

<400>  28

Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln 
1               5                   10                  15      


Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro 
            20                  25                  30          


Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr 
        35                  40                  45              


Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr 
    50                  55                  60                  


Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys 
                85                  90                  95      


Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro 
            100                 105                 110         


Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala 
        115                 120                 125             


Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro 
    130                 135                 140                 


Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe 
145                 150                 155                 160 


Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr 
                165                 170                 175     


Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser 
            180                 185                 190         


Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys 
        195                 200                 205             


Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu 
    210                 215                 220                 


Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser 
225                 230                 235                 240 


Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu 
                245                 250                 255     


Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp 
            260                 265                 270         


Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser 
        275                 280                 285             


Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu 
    290                 295                 300                 


His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg 
305                 310                 315                 320 


Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile 
                325                 330                 335     


Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp 
            340                 345                 350         


Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser 
        355                 360                 365             


Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val 
    370                 375                 380                 


Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu 
385                 390                 395                 400 


Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser 
                405                 410                 415     


Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp 
            420                 425                 430         


Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro 
        435                 440                 445             


Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr 
    450                 455                 460                 


Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr 
465                 470                 475                 480 


Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg 
                485                 490                 495     


Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg 
            500                 505                 510         


Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser 
        515                 520                 525             


Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val 
    530                 535                 540                 


Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly 
545                 550                 555                 560 


Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala 
                565                 570                 575     


Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys 
            580                 585                 590         


Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg 
        595                 600                 605         


<210>  29
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD fragment

<400>  29

Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln 
1               5                   10                  15      


Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro 
            20                  25                  30          


Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr 
        35                  40                  45              


Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr 
    50                  55                  60                  


Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys 
                85                  90                  95      


Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro 
            100                 105                 110         


Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala 
        115                 120                 125             


Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro 
    130                 135                 140                 


Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe 
145                 150                 155                 160 


Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr 
                165                 170                 175     


Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser 
            180                 185                 190         


Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys 
        195                 200                 205             


Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu 
    210                 215                 220                 


Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser 
225                 230                 235                 240 


Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu 
                245                 250                 255     


Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp 
            260                 265                 270         


Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser 
        275                 280                 285             


Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu 
    290                 295                 300                 


His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg 
305                 310                 315                 320 


Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile 
                325                 330                 335     


Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp 
            340                 345                 350         


Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser 
        355                 360                 365             


Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val 
    370                 375                 380                 


Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu 
385                 390                 395                 400 


Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser 
                405                 410                 415     


Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp 
            420                 425                 430         


Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro 
        435                 440                 445             


Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr 
    450                 455                 460                 


Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr 
465                 470                 475                 480 


Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg 
                485                 490                 495     


Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg 
            500                 505                 510         


Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser 
        515                 520                 525             


Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val 
    530                 535                 540                 


Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly 
545                 550                 555                 560 


Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala 
                565                 570                 575     


Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys 
            580                 585                 590         


Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg 
        595                 600                 605         


<210>  30
<211>  394
<212>  PRT
<213>  Pan troglodytes

<220>
<223>  Chimpanzee GFRAL protein

<400>  30

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Leu Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Pro Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  31
<211>  394
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  Cynomolgus GFRAL protein

<400>  31

Phe Val Val Val Val Ile Gln Ala Leu Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


His Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Leu Ser Gln Val Pro Gly Glu Leu 
385                 390                 


<210>  32
<211>  395
<212>  PRT
<213>  Ailuropoda melanoleuca

<220>
<223>  Giant Panda GFRAL protein 

<400>  32

Met Val Val Phe Ile Phe Leu Ala Val Ala Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Glu Thr Ile Asp Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ser 
        35                  40                  45              


Cys Asn Val Ser Glu Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Lys Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Asp Asn Leu Tyr Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Glu Gln Cys Ile Asn Glu Ser Gly Asn Val Lys Glu Asp Asn 
            100                 105                 110         


Gln Ser Lys Trp Asn Leu Thr Thr Leu Pro Tyr Gln Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Pro Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Arg Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Val Val Pro Pro Pro Thr Cys Leu Asp Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Ser Lys Cys Trp Gln His Val Thr Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Leu Cys Ile Ser Thr Leu Ser Gln Gln Asp Leu Ile Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Arg Arg Ser Cys Phe Asp Tyr 
305                 310                 315                 320 


Leu Thr Leu Ser Asn Val Lys Gly Met Ala Leu His Lys Arg Lys Pro 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Ile Arg Ile Pro Gly Gly Leu 
385                 390                 395 


<210>  33
<211>  395
<212>  PRT
<213>  Canis familiaris

<220>
<223>  Dog GFRAL protein 

<400>  33

Met Ile Val Phe Ile Phe Leu Ala Met Val Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Ile Asp Cys Thr His Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Ser Asp Ala Asp Gly Cys Lys His Ala Trp Arg Ile Met Glu Tyr Ser 
        35                  40                  45              


Cys Asn Val Ser Val Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Asn Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Asn Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Asp Asn Ile Tyr Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Glu Gln Cys Met Asn Glu Ser Asp Asn Met Lys Glu Asp Asn 
            100                 105                 110         


Gln Tyr Lys Trp Asn Leu Thr Thr Leu Pro Tyr His Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Thr Gln Leu Ala Ala Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Val Val Pro Pro Pro Ser Cys Leu Asp Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Ser Lys Cys Trp Gln His Met Ile Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Leu Cys Ile Ser Thr Leu Ser Gln Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Gln Cys Thr Cys Arg Thr Thr Thr Gln Asn Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Gly Arg Ser Cys Phe Asp Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Met Ala Leu His Glu Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Ile Gln Ile Pro Gly Gly Leu 
385                 390                 395 


<210>  34
<211>  395
<212>  PRT
<213>  Felis catus

<220>
<223>  Cat GFRAL protein 

<400>  34

Ser Val Leu Ile Val Ile Ser Ala Met Val Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Ile Asp Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Ser Asp Thr Asn Gly Cys Lys Leu Ala Trp Arg Lys Met Glu Asp Ser 
        35                  40                  45              


Cys Asn Val Ser Asp Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Asn Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Asn Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Gly Asn Leu His Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Glu Ser Asp Asn Met Lys Glu Asp Asn 
            100                 105                 110         


Gln Ser Lys Trp Asn Leu Thr Thr Leu Pro Tyr Asn Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Pro Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Ser Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Ile Val Pro Pro Pro Thr Cys Leu Asn Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Trp Lys Cys Trp Gln Gln Val Thr Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Phe Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Ile Leu Gly Thr Val Leu 
        275                 280                 285             


Gln Ala Gln Cys Thr Cys Arg Thr Ile Thr Gln Gly Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Arg Arg Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Ile Ala Leu His Lys Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Val Gln Ile Leu Glu Glu Leu 
385                 390                 395 


<210>  35
<211>  395
<212>  PRT
<213>  Sus scrofa

<220>
<223>  Pig GFRAL protein 

<400>  35

Ser Val Ile Ala Val Leu Gln Ala Val Gly Leu Tyr Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Thr Asp Cys Thr Tyr Leu Arg Glu Leu Cys Leu 
            20                  25                  30          


Asn Asp Thr Asp Gly Cys Lys Gln Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Val Ser Asp Pro Gly Asn Thr Cys Gln Met Lys Asp Ser Ser 
    50                  55                  60                  


Ser Cys Asn Gln Ser Ile Gln Ser Leu Ala Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Asp Cys Leu Cys Ser Asp Asp Leu Tyr Cys Thr Val Asn Asn Leu 
                85                  90                  95      


Ile Gly Lys Lys Cys Thr Asn Glu Ser Asp Asn Met Lys Glu Asp Gly 
            100                 105                 110         


Val Phe Lys Arg Asn Leu Thr Ala Pro Ser Tyr His Gly Ile Arg Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Arg Asp Thr Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Val Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Arg Val Pro Ala Pro Thr Cys Leu Asp Val 
    210                 215                 220                 


Ile Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Ile 
225                 230                 235                 240 


Phe Gln Ala Lys Cys Trp Gln His Val Thr Ala Lys Cys His Asp Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Thr Leu Asn Lys Gln Asp Phe Thr Cys Ser Arg 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Met Gly Thr Leu Gly Thr Ala Leu 
        275                 280                 285             


Gln Gly Gln Cys Thr Cys Arg Thr Thr Thr Gln Ser Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Gly Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Ile Ala Leu His Lys Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Ser Leu Ser Gly Cys Gln Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Phe Lys Leu Arg Asn Phe Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp Pro Ser Pro Ile Gln Ile Pro Gly Glu Pro 
385                 390                 395 


<210>  36
<211>  324
<212>  PRT
<213>  Bos taurus

<220>
<223>  Bovine GFRAL protein 

<400>  36

Pro Leu Ile Val Val Ile Gln Ala Val Gly Leu Cys Leu Asn Lys Ser 
1               5                   10                  15      


Ala Ser Gln Thr Thr Asp Cys Thr Tyr Leu Arg Glu Leu Cys Leu Ser 
            20                  25                  30          


Asp Ala Asp Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala Cys 
        35                  40                  45              


Asn Val Ser Gly Asn Thr Cys Gln Met Lys Asn Ser Ser Ser Cys Gly 
    50                  55                  60                  


Leu Ser Ile Gln Ser Leu Val Glu Ser Asn Leu Gln Phe Lys Asp Cys 
65                  70                  75                  80  


Leu Cys Phe Asp Asp Leu Tyr Cys Thr Phe Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Glu Ser Asp Asn Ile Lys Glu Asp Asn Lys Tyr Lys 
            100                 105                 110         


Trp Asn Leu Thr Thr Leu Ser Tyr His Gly Gly Arg Gly Val Gln Ser 
        115                 120                 125             


Cys Leu Glu Val Ala Glu Val Cys Ile Gly Asp Ala Leu Cys Asn Ala 
    130                 135                 140                 


Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asp Gly Lys Leu Cys 
145                 150                 155                 160 


Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Met 
                165                 170                 175     


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Pro Ala 
            180                 185                 190         


Asp Glu Pro Cys Gln Gln Ser Arg Glu Ala Leu His Ser Arg Pro Cys 
        195                 200                 205             


Ala Val Asn Arg Val Pro Thr Pro Thr Cys Leu Asp Val Ile His Ser 
    210                 215                 220                 


Cys Gln Asp Asp Glu Leu Cys Arg Arg Arg Tyr Arg Ile Phe Gln Ala 
225                 230                 235                 240 


Lys Cys Trp Gln His Val Met Arg Lys Cys His Glu Asp Glu Thr Cys 
                245                 250                 255     


Ile Gly Thr Leu Ser Lys Gln Asp Leu Ala Cys Ser Gly Ser Asp Asp 
            260                 265                 270         


Cys Lys Ala Ala Tyr Ile Gly Thr Leu Gly Thr Val Leu Gln Gly Gln 
        275                 280                 285             


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Thr 
    290                 295                 300                 


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Asn Lys Pro Thr 
305                 310                 315                 320 


Gln Asn Leu Lys 
                


<210>  37
<211>  393
<212>  PRT
<213>  Mus musculus

<220>
<223>  Mouse GFRAL protein

<400>  37

Met Leu Val Phe Ile Phe Leu Ala Val Thr Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu 
            20                  25                  30          


Ile Asp Ala Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr 
        35                  40                  45              


Cys Leu Thr Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu 
65                  70                  75                  80  


Cys Leu Cys Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp 
            100                 105                 110         


Lys Trp Asn Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met 
        115                 120                 125             


Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Glu Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu 
                245                 250                 255     


Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Glu Ser Cys Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln 
        275                 280                 285             


Val Pro Cys Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys 
    290                 295                 300                 


Met Ile Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys 
                325                 330                 335     


Glu Ile Thr Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Glu Leu Leu 
            340                 345                 350         


Tyr Val Val Val Cys Met Ala Val Thr Cys Gly Ile Leu Phe Leu Val 
        355                 360                 365             


Met Leu Lys Leu Arg Ile Gln Ser Glu Lys Arg Asp Pro Ser Ser Ile 
    370                 375                 380                 


Glu Ile Ala Gly Gly Val Ile Ile Gln 
385                 390             


<210>  38
<211>  394
<212>  PRT
<213>  Rattus norvegicus

<220>
<223>  Rat GFRAL protein

<400>  38

Met Leu Val Phe Ile Phe Leu Ala Val Arg Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala Tyr Phe Met Arg Gln Cys Leu 
            20                  25                  30          


Thr Asp Thr Asp Gly Cys Lys Gln Ser Trp Arg Ser Met Glu Asp Ala 
        35                  40                  45              


Cys Leu Val Ser Gly Asp Ser Cys Lys Ile Asn Asn Pro Leu Pro Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ser Leu Val Glu Lys His Phe Gln Phe Lys Gly 
65                  70                  75                  80  


Cys Leu Cys Thr Asp Asp Leu His Cys Thr Val Asn Lys Ile Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Ser Met Lys Lys Asp Asn Lys Tyr 
            100                 105                 110         


Lys Arg Asn Leu Thr Thr Pro Leu Tyr His Asp Thr Gly Phe Lys Gln 
        115                 120                 125             


Met Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Thr Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Val Val Pro Pro Pro Thr Cys Leu Ser Val 
    210                 215                 220                 


Ile His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr Tyr Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Thr Glu Cys Trp Pro His Val Ala Gly Lys Cys Arg Glu Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Ser Cys Arg Ala Ala Tyr Leu Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Pro Cys Ala Cys Arg Ser Ile Thr Gln Gly Glu Glu Pro Leu 
    290                 295                 300                 


Cys Met Ala Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Arg Lys His Ser 
                325                 330                 335     


Lys Glu Ile Thr Leu Thr Gly Phe Asn Ser Pro Phe Ser Gly Glu Leu 
            340                 345                 350         


Ile Tyr Val Val Val Cys Met Val Val Thr Ser Gly Ile Leu Ser Leu 
        355                 360                 365             


Val Met Leu Lys Leu Arg Ile Pro Ser Lys Lys Arg Asp Pro Ala Pro 
    370                 375                 380                 


Ile Glu Ile Ala Gly Ala Val Ile Ile Gln 
385                 390                 


<210>  39
<211>  388
<212>  PRT
<213>  Cricetulus griseus

<220>
<223>  Chinese Hamster GFRAL protein

<400>  39

Met Asp Val Leu Leu Asn His Ser Phe Thr Ser Phe Ile Glu Glu Ser 
1               5                   10                  15      


Thr Leu Pro Ser Asp Leu Val Pro Arg Ser Asn Val Thr Gln Gly Phe 
            20                  25                  30          


Leu Arg Glu Asp Thr Phe Leu Thr Ala Glu Arg Lys Asp Asp Cys Val 
        35                  40                  45              


Ala Ala Ala Glu Ala Cys Gln Glu Ser Val His Cys Ser Leu Leu His 
    50                  55                  60                  


Glu Asn Phe Lys Lys Ala Cys Gly Lys Gly Thr Ala Gln Cys His Thr 
65                  70                  75                  80  


Leu Ser Gly Gln Gln Phe Cys Val Ala Leu Arg Glu Ser Leu Arg Glu 
                85                  90                  95      


Thr Val Leu Trp Asp Cys Gln Cys Gly Phe Pro Leu Glu Gly Asp Cys 
            100                 105                 110         


Ile Arg Ile Trp Lys Gly Leu Phe Glu Asp Ile Cys Ile Glu Asp Thr 
        115                 120                 125             


Gln Ile Asn Gln Ile Ala Thr Phe Ser Gln Asp Asn Glu Asp Arg Leu 
    130                 135                 140                 


Lys Glu Asp Ile Ala Ser Asp Asn Leu Lys Lys Asp Asn Lys Phe Lys 
145                 150                 155                 160 


Trp Asp Leu Thr Thr Leu His His Ala Cys Ser Ala Asn Gly Asn Leu 
                165                 170                 175     


Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn 
            180                 185                 190         


Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln 
        195                 200                 205             


Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys Pro 
    210                 215                 220                 


Cys Ala Leu Asn Val Val Pro Pro Pro Thr Cys Leu Ser Val Ile His 
225                 230                 235                 240 


Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr Arg Tyr Gln Thr Phe Gln 
                245                 250                 255     


Ser Glu Cys Trp Phe His Val Met Gly Lys Cys His Glu Asp Glu Thr 
            260                 265                 270         


Cys Ile Gly Thr Leu Gly Lys Gln Asp Leu Ile Cys Ser Gly Ser Asp 
        275                 280                 285             


Ser Cys Arg Ala Ala Tyr Leu Gly Thr Phe Gly Thr Val Leu Gln Val 
    290                 295                 300                 


Pro Cys Ala Cys Arg Ser Ile Thr Gln Asp Glu Glu Pro Leu Cys Met 
305                 310                 315                 320 


Thr Phe Gln His Met Leu Gln Ser Lys Ser Cys Phe Asn Tyr Pro Thr 
                325                 330                 335     


Pro Asn Val Lys Asp Ile Ser Ser Tyr Lys Gly Lys His Ser Lys Glu 
            340                 345                 350         


Ile Thr Leu Thr Gly Phe Glu Ser Pro Phe Asn Gly Glu Leu Val Tyr 
        355                 360                 365             


Ala Val Leu Cys Met Val Val Thr Cys Gly Ile Leu Phe Leu Val Met 
    370                 375                 380                 


Leu Lys Leu Arg 
385             


<210>  40
<211>  319
<212>  PRT
<213>  Ornithorhynchus anatinus

<220>
<223>  Platypus GFRAL protein 

<400>  40

Met Lys His Tyr Phe Leu Phe Val Val Leu Met Leu Gly Phe Lys Cys 
1               5                   10                  15      


Glu Ser Ala Ser Leu Thr Thr Gly Cys Leu His Leu Arg Lys Gln Cys 
            20                  25                  30          


Val Ser Ala Met Asp Gly Cys Glu Ser Ala Trp Ala Val Ile Glu Asp 
        35                  40                  45              


Val Cys Asn Val Ser Gly His Asn Cys Thr Met Lys Glu Ser Leu Asn 
    50                  55                  60                  


Cys Asn Leu Ser Ile Gln Leu Leu Ala Asp Arg Tyr Pro Ala Phe Lys 
65                  70                  75                  80  


Asp Cys Leu Cys Ala Glu Asp Ile Ser Cys Ser Ala Thr Asn Phe Leu 
                85                  90                  95      


Gly Arg Lys Cys Ile Ile Lys Thr Glu Asn Glu His Lys Asp Lys Asn 
            100                 105                 110         


Ile Lys Ser Leu Trp Asn Ser Thr Ser Leu Leu Gln His Gly Phe Lys 
        115                 120                 125             


Gly Thr Arg Ser Cys Leu Glu Val Thr Val Ala Cys Val Gly Asp Thr 
    130                 135                 140                 


Val Cys Asn Lys Gln Leu Ala Arg Phe Leu Lys Asp Cys Ser Thr His 
145                 150                 155                 160 


Gly Ser Leu Cys Asn Met Asn Gln Cys Gln Ala Ala Ile Arg Phe Phe 
                165                 170                 175     


Tyr Gln Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp 
            180                 185                 190         


Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His 
        195                 200                 205             


Ser Lys Pro Cys Ala Val Asn Val Val Pro Thr Pro Ser Cys Leu Asn 
    210                 215                 220                 


Val Ile Arg Ser Cys Arg Asp Asp Glu Leu Cys Arg Gln Arg Phe Glu 
225                 230                 235                 240 


Thr Phe Gln Ser Lys Cys Trp Gln Asp Met Asp Lys Cys Ser Asp Asp 
                245                 250                 255     


Glu Thr Cys Ile Val Thr Leu Asn Lys Glu Asn Ile Thr Cys Ser Arg 
            260                 265                 270         


Asn Glu Glu Cys Arg Glu Ala Tyr Ile Gly Thr Leu Gly Thr Tyr Leu 
        275                 280                 285             


His Val Gln Cys Thr Cys Ser Thr Leu Ser Leu Thr Glu Glu Tyr Leu 
    290                 295                 300                 


Cys Lys Ile Phe His His Ile Leu His Ser Arg Ser Cys Phe Ser 
305                 310                 315                 


<210>  41
<211>  308
<212>  PRT
<213>  Macaca mulatta

<220>
<223>  Rhesus monkey GDF15 protein 

<400>  41

Met Pro Gly Gln Glu Leu Lys Thr Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Trp Pro Pro His Gly Gly Ala Met Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Asp Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Ile Gln Ala Pro Glu Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Val Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Ile His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Arg Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Val Lys Ser Ser Ser Ser 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Leu Arg Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp Arg Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val His Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Glu Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Met Asn Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  42
<211>  308
<212>  PRT
<213>  Hylobates sp.

<220>
<223>  Gibbon GDF15 protein 

<400>  42

Met Pro Arg Gln Glu Pro Arg Met Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Pro Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Lys Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Val Asn Gln Ser Trp Glu Asp Leu Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Arg Ser Arg Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  43
<211>  308
<212>  PRT
<213>  Pan troglodytes

<220>
<223>  Chimpanzee GDF15 protein 

<400>  43

Met Pro Arg Gln Glu Leu Arg Thr Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Ser Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ala Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ala Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Ser Arg Ala Ala Arg Gly Leu 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ser Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  44
<211>  308
<212>  PRT
<213>  Pongo sp.

<220>
<223>  Orangutan GDF15 protein

<400>  44

Met Pro Arg Gln Glu Leu Arg Thr Leu Asn Gly Phe Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Asp Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Leu Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Arg Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  45
<211>  308
<212>  PRT
<213>  Bos taurus

<220>
<223>  Cow GDF15 protein 

<400>  45

Met Pro Gly Gln Arg Pro Ala Ala Pro His Arg Ser Arg Met Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Phe Ser Trp Leu Arg Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Thr Gln Glu His Leu Gln Thr Phe Gln Gly Pro Ser Asn Val His Ser 
        35                  40                  45              


Ser Pro Asp Ile Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp 
    50                  55                  60                  


Leu Leu Thr Arg Leu Arg Ala Asn Gln Thr Trp Glu Asp Ser Asn Pro 
65                  70                  75                  80  


Asp Leu Ile Pro Pro Pro Gln Val Arg Ile Val Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Pro Gly Gly His Leu His Leu Arg Ile Pro Arg Val Asn Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Lys Ala Trp Ser Ser Trp Asp Val Thr Arg Pro Leu Arg 
    130                 135                 140                 


Arg Gln Leu Arg Leu Gly Gly Ser Arg Gly Pro Ser Ile Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Ala Arg Pro Asp Gln Leu Gln Glu Ala Leu Pro Ser Ala Pro 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Ser Ala Thr Arg Gly Arg Arg 
            180                 185                 190         


His Ala His Ala His Thr Arg Asp Gly Cys Pro Leu Gly Glu Gly Arg 
        195                 200                 205             


Cys Cys His Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Leu Ala Pro Arg Glu Leu Asp Val Arg Met Cys Ile 
225                 230                 235                 240 


Gly Ala Cys Pro Ser His Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  46
<211>  308
<212>  PRT
<213>  Sus scrofa

<220>
<223>  Pig GDF15 protein 

<400>  46

Met Pro Gly Gln Leu Pro Ser Pro Pro Arg Arg Ser Pro Thr Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Leu Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Leu Pro Gly Pro Ser Asp Val His Ser 
        35                  40                  45              


Ser Ser Asp Val Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp 
    50                  55                  60                  


Leu Leu Thr Arg Leu Arg Ala Asn Gln Thr Trp Glu Asp Ser Asn Pro 
65                  70                  75                  80  


Asn Leu Ile Pro Ala Pro Gln Val Arg Ile Val Thr Pro Lys Phe Arg 
                85                  90                  95      


Leu Gly Pro Gly Gly His Leu His Leu Arg Ile Pro Arg Val Asn Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Ala Arg Ser Ser Trp Asp Val Thr Arg Pro Leu Arg 
    130                 135                 140                 


Arg Gln Leu Ser Val Gly Gly Ser Arg Gly Ser Ala Ile His Leu Arg 
145                 150                 155                 160 


Leu Leu Gln Arg Pro Asp Gln Leu Leu Glu Ala Leu Pro Ala Gly Gln 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Ser Ser Thr Arg Gly Arg Arg 
            180                 185                 190         


Asn Thr His Ala His Thr Arg Asp Gly Cys Pro Leu Gly Thr Gly Arg 
        195                 200                 205             


Cys Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Leu Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val 
225                 230                 235                 240 


Gly Ala Cys Pro Ser His Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  47
<211>  307
<212>  PRT
<213>  Canis familiaris

<220>
<223>  Dog GDF15 protein 

<400>  47

Met Pro Gly Gln Gly Pro Ala Pro Ala His Cys Ser Pro Met Leu Val 
1               5                   10                  15      


Ile Leu Val Met Leu Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Phe Pro Gly Pro Ser Asp Pro His Ser 
        35                  40                  45              


Ser Thr Asp Val Ser Arg Ile Gln Glu Leu Arg Lys Arg Tyr Glu His 
    50                  55                  60                  


Leu Gln Thr Lys Leu Arg Leu Asn Gln Gly Trp Ala Asp Ser Asn Pro 
65                  70                  75                  80  


Asp Leu Val Pro Ala Thr Arg Val Arg Ile Leu Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Pro Arg Gly His Leu His Leu Arg Ile Ala Arg Ala Asp Leu 
            100                 105                 110         


Thr Ala Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Glu Pro Ser Ser Trp Asp Val Thr Arg Pro Leu Gln 
    130                 135                 140                 


Arg Gln Leu Ser Arg Val Gly Ser Arg Thr Pro Thr Leu Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Pro Arg Trp Asp Arg Ser Arg Ala Leu Pro Ser Ala Arg Pro 
                165                 170                 175     


Gln Leu Glu Leu His Trp Arg Pro Arg Ala Ala Arg Gly Arg Arg Asn 
            180                 185                 190         


Ala His Ala His Ala Arg Asp Gly Cys Pro Leu Gly Glu Gly Arg Cys 
        195                 200                 205             


Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Gln Asp Leu Gly Trp Ala 
    210                 215                 220                 


Asn Trp Val Val Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val Gly 
225                 230                 235                 240 


Ala Cys Pro Ser Gln Phe Arg Ser Ala Asn Thr His Ala Gln Met Gln 
                245                 250                 255     


Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys Cys 
            260                 265                 270         


Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser Asp 
        275                 280                 285             


Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp Cys 
    290                 295                 300                 


His Cys Val 
305         


<210>  48
<211>  308
<212>  PRT
<213>  Ailuropoda melanoleuca

<220>
<223>  Giant panda GDF15 protein 

<400>  48

Met Pro Gly Gln Gly Leu Thr Pro Pro Pro Gly Ser Pro Met Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Phe Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Phe Pro Gly Pro Ser Asp Thr His Ser 
        35                  40                  45              


Ser Thr Asp Val Ser Arg Ala Gln Glu Phe Arg Lys Arg Tyr Ala His 
    50                  55                  60                  


Leu Gln Thr Arg Leu Trp Leu Asn Gln Ser Arg Ala Asp Ser Asn Ser 
65                  70                  75                  80  


Asp Leu Ile Pro Ala Ala Gln Val Arg Ile Leu Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Ser Gly Gly His Leu His Leu Arg Ile Ala Arg Ala Asp Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Glu Pro Ser Ser Trp Asp Val Thr Arg Pro Leu Gln 
    130                 135                 140                 


Arg Gln Leu Ser Leu Gly Gly Ser Arg Ala Pro Val Leu Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Pro Gln Trp Asp Pro Leu Gly Ala Thr Leu Pro Ser Ala Arg 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Arg Ala Ala Arg Gly Arg Arg 
            180                 185                 190         


Asn Ala His Ala His Gly Gly Asp Gly Cys Pro Leu Gly Glu Gly Arg 
        195                 200                 205             


Cys Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Val Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val 
225                 230                 235                 240 


Gly Ala Cys Pro Ser Gln Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Glu Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  49
<211>  298
<212>  PRT
<213>  Mustela furo

<220>
<223>  Ferret GDF15 protein 

<400>  49

His Ser Ser Pro Met Leu Pro Val Leu Leu Met Phe Ser Trp Leu Pro 
1               5                   10                  15      


Ser Gly Gly Ala Leu Ser Leu Ala Gln Glu Arg Leu Pro Ala Phe Pro 
            20                  25                  30          


Gly Pro Ser Asp Ala His Ser Ser Met Asp Ile Ser Arg Ala Gln Glu 
        35                  40                  45              


Phe Arg Lys His Tyr Glu His Leu Gln Thr Arg Leu Arg Leu Asn Gln 
    50                  55                  60                  


Ser Trp Gly Asp Ser Asn Ser Asp Leu Asn Leu Thr Ala Pro Val Arg 
65                  70                  75                  80  


Ile Leu Thr Pro Lys Leu Arg Leu Gly Pro Gly Gly His Leu His Leu 
                85                  90                  95      


Arg Ile Ala Leu Ala Asp Leu Thr Glu Gly Leu Pro Ala Thr Ser Arg 
            100                 105                 110         


Leu His Gln Ala Leu Leu Arg Leu Ser Pro Met Glu Pro Ser Ser Trp 
        115                 120                 125             


Asp Val Thr Arg Pro Leu Gln Arg Gln Leu Ser Leu Gly Gly Ser Arg 
    130                 135                 140                 


Ala Ser Ala Leu His Leu Arg Leu Leu Pro Arg Leu Asn Arg Leu Arg 
145                 150                 155                 160 


Ala Thr Leu Pro Ser Ala Arg Pro Gln Leu Glu Leu His Trp Arg Pro 
                165                 170                 175     


Ser Ala Ala Arg Gly Arg Arg Asp Ala His Ala His Ala Gly Asp Gly 
            180                 185                 190         


Cys Pro Leu Gly Glu Gly Arg Cys Cys Arg Leu Gln Ser Leu Arg Ala 
        195                 200                 205             


Ser Leu Glu Asp Leu Gly Trp Ala Asn Trp Val Val Ala Pro Arg Glu 
    210                 215                 220                 


Leu Asp Val Arg Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ser 
225                 230                 235                 240 


Ala Asn Thr His Ala Gln Met Gln Ala Arg Leu His Gly Leu Asn Pro 
                245                 250                 255     


Asp Ala Ala Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Glu Pro Val 
            260                 265                 270         


Val Leu Leu His Gln Asp Ser Asp Gly Arg Val Ser Leu Thr Pro Phe 
        275                 280                 285             


Asp Asp Leu Val Ala Lys Asp Cys His Cys 
    290                 295             


<210>  50
<211>  303
<212>  PRT
<213>  Mus musculus

<220>
<223>  Mouse GDF15 protein

<400>  50

Met Ala Pro Pro Ala Leu Gln Ala Gln Pro Pro Gly Gly Ser Gln Leu 
1               5                   10                  15      


Arg Phe Leu Leu Phe Leu Leu Leu Leu Leu Leu Leu Leu Ser Trp Pro 
            20                  25                  30          


Ser Gln Gly Asp Ala Leu Ala Met Pro Glu Gln Arg Pro Ser Gly Pro 
        35                  40                  45              


Glu Ser Gln Leu Asn Ala Asp Glu Leu Arg Gly Arg Phe Gln Asp Leu 
    50                  55                  60                  


Leu Ser Arg Leu His Ala Asn Gln Ser Arg Glu Asp Ser Asn Ser Glu 
65                  70                  75                  80  


Pro Ser Pro Asp Pro Ala Val Arg Ile Leu Ser Pro Glu Val Arg Leu 
                85                  90                  95      


Gly Ser His Gly Gln Leu Leu Leu Arg Val Asn Arg Ala Ser Leu Ser 
            100                 105                 110         


Gln Gly Leu Pro Glu Ala Tyr Arg Val His Arg Ala Leu Leu Leu Leu 
        115                 120                 125             


Thr Pro Thr Ala Arg Pro Trp Asp Ile Thr Arg Pro Leu Lys Arg Ala 
    130                 135                 140                 


Leu Ser Leu Arg Gly Pro Arg Ala Pro Ala Leu Arg Leu Arg Leu Thr 
145                 150                 155                 160 


Pro Pro Pro Asp Leu Ala Met Leu Pro Ser Gly Gly Thr Gln Leu Glu 
                165                 170                 175     


Leu Arg Leu Arg Val Ala Ala Gly Arg Gly Arg Arg Ser Ala His Ala 
            180                 185                 190         


His Pro Arg Asp Ser Cys Pro Leu Gly Pro Gly Arg Cys Cys His Leu 
        195                 200                 205             


Glu Thr Val Gln Ala Thr Leu Glu Asp Leu Gly Trp Ser Asp Trp Val 
    210                 215                 220                 


Leu Ser Pro Arg Gln Leu Gln Leu Ser Met Cys Val Gly Glu Cys Pro 
225                 230                 235                 240 


His Leu Tyr Arg Ser Ala Asn Thr His Ala Gln Ile Lys Ala Arg Leu 
                245                 250                 255     


His Gly Leu Gln Pro Asp Lys Val Pro Ala Pro Cys Cys Val Pro Ser 
            260                 265                 270         


Ser Tyr Thr Pro Val Val Leu Met His Arg Thr Asp Ser Gly Val Ser 
        275                 280                 285             


Leu Gln Thr Tyr Asp Asp Leu Val Ala Arg Gly Cys His Cys Ala 
    290                 295                 300             


<210>  51
<211>  301
<212>  PRT
<213>  Cavia porcellus

<220>
<223>  Guinea pig GDF15 protein 

<400>  51

Met Pro Ala Leu Gly Phe Thr Leu Leu Leu Leu Ala Ala Val Ser Arg 
1               5                   10                  15      


Pro Pro Pro Gly Gly Ala Ser Gly Pro Ala Glu Lys Leu Pro Ala Glu 
            20                  25                  30          


Pro Asp Pro Asp Leu Asp Pro Asp Arg Asp Pro Asp Pro Ala Ala His 
        35                  40                  45              


Pro Ala Arg Glu Leu Arg Arg Arg Phe Glu Asp Leu Leu Ala Arg Leu 
    50                  55                  60                  


Arg Ala Asn Arg Ser Ala Asp Ala Leu Pro Ala Glu Arg Ser Pro Ala 
65                  70                  75                  80  


Pro Val Val His Thr Leu Thr Pro Asp Val Arg Arg Gly His Asp Gly 
                85                  90                  95      


Ser Leu His Leu Arg Ile Pro Arg Ala Ser Leu Pro Pro Gly Val Pro 
            100                 105                 110         


Arg Ala Ser Arg Val Gln His Ala Leu Leu Arg Leu Ser Pro Glu Thr 
        115                 120                 125             


Arg Glu Pro Trp Asp Val Thr Arg Pro Leu Gln Arg Gln Leu Arg Leu 
    130                 135                 140                 


Leu Asp Pro Arg Ala Pro Ala Leu Leu Leu His Leu Trp Pro Pro Ser 
145                 150                 155                 160 


Asp Arg Trp Arg Glu Leu Ser Ser Ala Pro Pro Arg Leu Glu Leu His 
                165                 170                 175     


Leu Arg Thr Arg Ser Ala Arg Gly Arg Arg Ser Thr Arg Met Arg Thr 
            180                 185                 190         


Arg Asp Asp Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        195                 200                 205             


Val Arg Ala Ser Leu Gln Asp Leu Gly Trp Thr Asp Trp Val Leu Ser 
    210                 215                 220                 


Pro Arg Glu Leu His Val Gly Ile Cys Met Gly Glu Cys Pro Ser Leu 
225                 230                 235                 240 


Tyr Arg Ser Ala Asn Thr His Ala Gln Val Lys Ala Arg Leu His Gly 
                245                 250                 255     


Leu Lys Pro Asp Ser Val Pro Ala Pro Cys Cys Val Pro Ser Ser Tyr 
            260                 265                 270         


Asp Leu Val Val Leu Met His Lys Thr Asp Gly Gly Ile Ala Leu His 
        275                 280                 285             


Thr Tyr Asp Asp Leu Ile Ala Lys Gly Cys His Cys Ala 
    290                 295                 300     


<210>  52
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1 - 20 times

<400>  52

Gly Ser Gly Gly Ser 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (1)..(1)
<223>  Repeat 1-20 times

<220>
<221>  REPEAT
<222>  (2)..(2)
<223>  Repeat 1-20 times

<220>
<221>  REPEAT
<222>  (3)..(3)
<223>  Repeat 1-20 times

<220>
<221>  REPEAT
<222>  (4)..(4)
<223>  Repeat 1-20 times

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  Repeat 1-20 times

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1-20 times

<400>  53

Gly Ser Gly Ser Gly 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (5)..(5)
<223>  Repeat 1 - 20 times

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1 - 20 times

<400>  54

Gly Ser Gly Gly Ser 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (4)..(4)
<223>  Repeat 1 - 20 times

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1 - 20 times

<400>  55

Gly Ser Gly Ser Gly 
1               5   


<210>  56
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (4)..(4)
<223>  Repeat 1 - 20 times

<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  Repeat 1 - 20 times

<400>  56

Gly Gly Gly Ser 
1               


<210>  57
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  57

Gly Gly Ser Gly 
1               


<210>  58
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  58

Gly Gly Ser Gly Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  59

Gly Ser Gly Ser Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  60

Gly Ser Gly Gly Gly 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  61

Gly Gly Gly Ser Gly 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  62

Gly Ser Ser Ser Gly 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1 - 50 times

<400>  63

Gly Ser Gly Gly Ser 
1               5   


<210>  64
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  Repeat 1 - 50 times

<400>  64

Gly Gly Gly Ser 
1               


<210>  65
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1 - 50 times

<400>  65

Gly Gly Gly Gly Ser 
1               5   


<210>  66
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  66

Gly Gly Gly Ser 
1               


<210>  67
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Flexible linker

<400>  67

Gly Gly Gly Gly Ser 
1               5   
