                         SEQUENCE LISTING

<110>  University of Louisville Research Foundation, Inc.
       Ratajczak, Mariusz Z
       Ratajczak, Janina
       Kucia, Magdalena
       Miller, Donald
 
<120>  METHODS AND COMPOSITIONS FOR EX VIVO EXPANSION OF VERY SMALL 
       EMBRYONIC-LIKE STEM CELLS (VSELS)

<130>  1577/40 PCT

<150>  US 62/303,888
<151>  2016-03-04

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  4110
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (54)..(2297)

<400>  1
gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aag atg          56
                                                           Met            
                                                           1              

gcg gac gag gcg gcc ctc gcc ctt cag ccc ggc ggc tcc ccc tcg gcg        104
Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser Ala           
            5                   10                  15                    

gcg ggg gcc gac agg gag gcc gcg tcg tcc ccc gcc ggg gag ccg ctc        152
Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro Leu           
        20                  25                  30                        

cgc aag agg ccg cgg aga gat ggt ccc ggc ctc gag cgg agc ccg ggc        200
Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro Gly           
    35                  40                  45                            

gag ccc ggt ggg gcg gcc cca gag cgt gag gtg ccg gcg gcg gcc agg        248
Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala Arg           
50                  55                  60                  65            

ggc tgc ccg ggt gcg gcg gcg gcg gcg ctg tgg cgg gag gcg gag gca        296
Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu Ala           
                70                  75                  80                

gag gcg gcg gcg gca ggc ggg gag caa gag gcc cag gcg act gcg gcg        344
Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala Ala           
            85                  90                  95                    

gct ggg gaa gga gac aat ggg ccg ggc ctg cag ggc cca tct cgg gag        392
Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg Glu           
        100                 105                 110                       

cca ccg ctg gcc gac aac ttg tac gac gaa gac gac gac gac gag ggc        440
Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu Gly           
    115                 120                 125                           

gag gag gag gaa gag gcg gcg gcg gcg gcg att ggg tac cga gat aac        488
Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp Asn           
130                 135                 140                 145           

ctt ctg ttc ggt gat gaa att atc act aat ggt ttt cat tcc tgt gaa        536
Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys Glu           
                150                 155                 160               

agt gat gag gag gat aga gcc tca cat gca agc tct agt gac tgg act        584
Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp Thr           
            165                 170                 175                   

cca agg cca cgg ata ggt cca tat act ttt gtt cag caa cat ctt atg        632
Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met           
        180                 185                 190                       

att ggc aca gat cct cga aca att ctt aaa gat tta ttg ccg gaa aca        680
Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr           
    195                 200                 205                           

ata cct cca cct gag ttg gat gat atg aca ctg tgg cag att gtt att        728
Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile           
210                 215                 220                 225           

aat atc ctt tca gaa cca cca aaa agg aaa aaa aga aaa gat att aat        776
Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn           
                230                 235                 240               

aca att gaa gat gct gtg aaa tta ctg caa gag tgc aaa aaa att ata        824
Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile           
            245                 250                 255                   

gtt cta act gga gct ggg gtg tct gtt tca tgt gga ata cct gac ttc        872
Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe           
        260                 265                 270                       

agg tca agg gat ggt att tat gct cgc ctt gct gta gac ttc cca gat        920
Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp           
    275                 280                 285                           

ctt cca gat cct caa gcg atg ttt gat att gaa tat ttc aga aaa gat        968
Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp           
290                 295                 300                 305           

cca aga cca ttc ttc aag ttt gca aag gaa ata tat cct gga caa ttc       1016
Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe           
                310                 315                 320               

cag cca tct ctc tgt cac aaa ttc ata gcc ttg tca gat aag gaa gga       1064
Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly           
            325                 330                 335                   

aaa cta ctt cgc aac tat acc cag aac ata gac acg ctg gaa cag gtt       1112
Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val           
        340                 345                 350                       

gcg gga atc caa agg ata att cag tgt cat ggt tcc ttt gca aca gca       1160
Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala           
    355                 360                 365                           

tct tgc ctg att tgt aaa tac aaa gtt gac tgt gaa gct gta cga gga       1208
Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly           
370                 375                 380                 385           

gat att ttt aat cag gta gtt cct cga tgt cct agg tgc cca gct gat       1256
Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp           
                390                 395                 400               

gaa ccg ctt gct atc atg aaa cca gag att gtg ttt ttt ggt gaa aat       1304
Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn           
            405                 410                 415                   

tta cca gaa cag ttt cat aga gcc atg aag tat gac aaa gat gaa gtt       1352
Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val           
        420                 425                 430                       

gac ctc ctc att gtt att ggg tct tcc ctc aaa gta aga cca gta gca       1400
Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala           
    435                 440                 445                           

cta att cca agt tcc ata ccc cat gaa gtg cct cag ata tta att aat       1448
Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn           
450                 455                 460                 465           

aga gaa cct ttg cct cat ctg cat ttt gat gta gag ctt ctt gga gac       1496
Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly Asp           
                470                 475                 480               

tgt gat gtc ata att aat gaa ttg tgt cat agg tta ggt ggt gaa tat       1544
Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr           
            485                 490                 495                   

gcc aaa ctt tgc tgt aac cct gta aag ctt tca gaa att act gaa aaa       1592
Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys           
        500                 505                 510                       

cct cca cga aca caa aaa gaa ttg gct tat ttg tca gag ttg cca ccc       1640
Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro Pro           
    515                 520                 525                           

aca cct ctt cat gtt tca gaa gac tca agt tca cca gaa aga act tca       1688
Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser           
530                 535                 540                 545           

cca cca gat tct tca gtg att gtc aca ctt tta gac caa gca gct aag       1736
Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala Lys           
                550                 555                 560               

agt aat gat gat tta gat gtg tct gaa tca aaa ggt tgt atg gaa gaa       1784
Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu Glu           
            565                 570                 575                   

aaa cca cag gaa gta caa act tct agg aat gtt gaa agt att gct gaa       1832
Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala Glu           
        580                 585                 590                       

cag atg gaa aat ccg gat ttg aag aat gtt ggt tct agt act ggg gag       1880
Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly Glu           
    595                 600                 605                           

aaa aat gaa aga act tca gtg gct gga aca gtg aga aaa tgc tgg cct       1928
Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp Pro           
610                 615                 620                 625           

aat aga gtg gca aag gag cag att agt agg cgg ctt gat ggt aat cag       1976
Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn Gln           
                630                 635                 640               

tat ctg ttt ttg cca cca aat cgt tac att ttc cat ggc gct gag gta       2024
Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val           
            645                 650                 655                   

tat tca gac tct gaa gat gac gtc tta tcc tct agt tct tgt ggc agt       2072
Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly Ser           
        660                 665                 670                       

aac agt gat agt ggg aca tgc cag agt cca agt tta gaa gaa ccc atg       2120
Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro Met           
    675                 680                 685                           

gag gat gaa agt gaa att gaa gaa ttc tac aat ggc tta gaa gat gag       2168
Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp Glu           
690                 695                 700                 705           

cct gat gtt cca gag aga gct gga gga gct gga ttt ggg act gat gga       2216
Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp Gly           
                710                 715                 720               

gat gat caa gag gca att aat gaa gct ata tct gtg aaa cag gaa gta       2264
Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu Val           
            725                 730                 735                   

aca gac atg aac tat cca tca aac aaa tca tag tgtaataatt gtgcaggtac     2317
Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser                                   
        740                 745                                           

aggaattgtt ccaccagcat taggaacttt agcatgtcaa aatgaatgtt tacttgtgaa     2377

ctcgatagag caaggaaacc agaaaggtgt aatatttata ggttggtaaa atagattgtt     2437

tttcatggat aatttttaac ttcattattt ctgtacttgt acaaactcaa cactaacttt     2497

ttttttttta aaaaaaaaaa ggtactaagt atcttcaatc agctgttggt caagactaac     2557

tttcttttaa aggttcattt gtatgataaa ttcatatgtg tatatataat tttttttgtt     2617

ttgtctagtg agtttcaaca tttttaaagt tttcaaaaag ccatcggaat gttaaattaa     2677

tgtaaaggga acagctaatc tagaccaaag aatggtattt tcacttttct ttgtaacatt     2737

gaatggtttg aagtactcaa aatctgttac gctaaacttt tgattcttta acacaattat     2797

ttttaaacac tggcattttc caaaactgtg gcagctaact ttttaaaatc tcaaatgaca     2857

tgcagtgtga gtagaaggaa gtcaacaata tgtggggaga gcactcggtt gtctttactt     2917

ttaaaagtaa tacttggtgc taagaatttc aggattattg tatttacgtt caaatgaaga     2977

tggcttttgt acttcctgtg gacatgtagt aatgtctata ttggctcata aaactaacct     3037

gaaaaacaaa taaatgcttt ggaaatgttt cagttgcttt agaaacatta gtgcctgcct     3097

ggatcccctt agttttgaaa tatttgccat tgttgtttaa atacctatca ctgtggtaga     3157

gcttgcattg atcttttcca caagtattaa actgccaaaa tgtgaatatg caaagccttt     3217

ctgaatctat aataatggta cttctactgg ggagagtgta atattttgga ctgctgtttt     3277

ccattaatga ggagagcaac aggcccctga ttatacagtt ccaaagtaat aagatgttaa     3337

ttgtaattca gccagaaagt acatgtctcc cattgggagg atttggtgtt aaataccaaa     3397

ctgctagccc tagtattatg gagatgaaca tgatgatgta acttgtaata gcagaatagt     3457

taatgaatga aactagttct tataatttat ctttatttaa aagcttagcc tgccttaaaa     3517

ctagagatca actttctcag ctgcaaaagc ttctagtctt tcaagaagtt catactttat     3577

gaaattgcac agtaagcatt tatttttcag accatttttg aacatcactc ctaaattaat     3637

aaagtattcc tctgttgctt tagtatttat tacaataaaa agggtttgaa atatagctgt     3697

tctttatgca taaaacaccc agctaggacc attactgcca gagaaaaaaa tcgtattgaa     3757

tggccatttc cctacttata agatgtctca atctgaattt atttggctac actaaagaat     3817

gcagtatatt tagttttcca tttgcatgat gtttgtgtgc tatagatgat attttaaatt     3877

gaaaagtttg ttttaaatta tttttacagt gaagactgtt ttcagctctt tttatattgt     3937

acatagtctt ttatgtaatt tactggcata tgttttgtag actgtttaat gactggatat     3997

cttccttcaa cttttgaaat acaaaaccag tgttttttac ttgtacactg ttttaaagtc     4057

tattaaaatt gtcatttgac ttttttctgt taacttaaaa aaaaaaaaaa aaa            4110


<210>  2
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


<210>  3
<211>  3604
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (433)..(1791)

<400>  3
gcatctcctc ctccctctcc ccgggctcct actggcctga ggttgagggc ggctgggggc       60

tcggggcagg ctccgcggcg ttcccctccc caccccggcc ctccgttcag ccgcgctcct      120

ccggggctgc ggttcctact gcgcgagctg ccagtggatt cgctcttttc ctccgtccgt      180

ggcccgcctg ggcggccttg ttctttccgc agcagccaga taaccttctg ttcggtgatg      240

aaattatcac taatggtttt cattcctgtg aaagtgatga ggaggataga gcctcacatg      300

caagctctag tgactggact ccaaggccac ggataggtgt ctgtttcatg tggaatacct      360

gacttcaggt caagggatgg tatttatgct cgccttgctg tagacttccc agatcttcca      420

gatcctcaag cg atg ttt gat att gaa tat ttc aga aaa gat cca aga cca      471
              Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro         
              1               5                   10                      

ttc ttc aag ttt gca aag gaa ata tat cct gga caa ttc cag cca tct        519
Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser           
    15                  20                  25                            

ctc tgt cac aaa ttc ata gcc ttg tca gat aag gaa gga aaa cta ctt        567
Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu           
30                  35                  40                  45            

cgc aac tat acc cag aac ata gac acg ctg gaa cag gtt gcg gga atc        615
Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile           
                50                  55                  60                

caa agg ata att cag tgt cat ggt tcc ttt gca aca gca tct tgc ctg        663
Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu           
            65                  70                  75                    

att tgt aaa tac aaa gtt gac tgt gaa gct gta cga gga gat att ttt        711
Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe           
        80                  85                  90                        

aat cag gta gtt cct cga tgt cct agg tgc cca gct gat gaa ccg ctt        759
Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu           
    95                  100                 105                           

gct atc atg aaa cca gag att gtg ttt ttt ggt gaa aat tta cca gaa        807
Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu           
110                 115                 120                 125           

cag ttt cat aga gcc atg aag tat gac aaa gat gaa gtt gac ctc ctc        855
Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu           
                130                 135                 140               

att gtt att ggg tct tcc ctc aaa gta aga cca gta gca cta att cca        903
Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro           
            145                 150                 155                   

agt tcc ata ccc cat gaa gtg cct cag ata tta att aat aga gaa cct        951
Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro           
        160                 165                 170                       

ttg cct cat ctg cat ttt gat gta gag ctt ctt gga gac tgt gat gtc        999
Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val           
    175                 180                 185                           

ata att aat gaa ttg tgt cat agg tta ggt ggt gaa tat gcc aaa ctt       1047
Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu           
190                 195                 200                 205           

tgc tgt aac cct gta aag ctt tca gaa att act gaa aaa cct cca cga       1095
Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg           
                210                 215                 220               

aca caa aaa gaa ttg gct tat ttg tca gag ttg cca ccc aca cct ctt       1143
Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro Pro Thr Pro Leu           
            225                 230                 235                   

cat gtt tca gaa gac tca agt tca cca gaa aga act tca cca cca gat       1191
His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser Pro Pro Asp           
        240                 245                 250                       

tct tca gtg att gtc aca ctt tta gac caa gca gct aag agt aat gat       1239
Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala Lys Ser Asn Asp           
    255                 260                 265                           

gat tta gat gtg tct gaa tca aaa ggt tgt atg gaa gaa aaa cca cag       1287
Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu Glu Lys Pro Gln           
270                 275                 280                 285           

gaa gta caa act tct agg aat gtt gaa agt att gct gaa cag atg gaa       1335
Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala Glu Gln Met Glu           
                290                 295                 300               

aat ccg gat ttg aag aat gtt ggt tct agt act ggg gag aaa aat gaa       1383
Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly Glu Lys Asn Glu           
            305                 310                 315                   

aga act tca gtg gct gga aca gtg aga aaa tgc tgg cct aat aga gtg       1431
Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp Pro Asn Arg Val           
        320                 325                 330                       

gca aag gag cag att agt agg cgg ctt gat ggt aat cag tat ctg ttt       1479
Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn Gln Tyr Leu Phe           
    335                 340                 345                           

ttg cca cca aat cgt tac att ttc cat ggc gct gag gta tat tca gac       1527
Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val Tyr Ser Asp           
350                 355                 360                 365           

tct gaa gat gac gtc tta tcc tct agt tct tgt ggc agt aac agt gat       1575
Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp           
                370                 375                 380               

agt ggg aca tgc cag agt cca agt tta gaa gaa ccc atg gag gat gaa       1623
Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro Met Glu Asp Glu           
            385                 390                 395                   

agt gaa att gaa gaa ttc tac aat ggc tta gaa gat gag cct gat gtt       1671
Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp Glu Pro Asp Val           
        400                 405                 410                       

cca gag aga gct gga gga gct gga ttt ggg act gat gga gat gat caa       1719
Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp Gly Asp Asp Gln           
    415                 420                 425                           

gag gca att aat gaa gct ata tct gtg aaa cag gaa gta aca gac atg       1767
Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu Val Thr Asp Met           
430                 435                 440                 445           

aac tat cca tca aac aaa tca tag tgtaataatt gtgcaggtac aggaattgtt      1821
Asn Tyr Pro Ser Asn Lys Ser                                               
                450                                                       

ccaccagcat taggaacttt agcatgtcaa aatgaatgtt tacttgtgaa ctcgatagag     1881

caaggaaacc agaaaggtgt aatatttata ggttggtaaa atagattgtt tttcatggat     1941

aatttttaac ttcattattt ctgtacttgt acaaactcaa cactaacttt ttttttttta     2001

aaaaaaaaaa ggtactaagt atcttcaatc agctgttggt caagactaac tttcttttaa     2061

aggttcattt gtatgataaa ttcatatgtg tatatataat tttttttgtt ttgtctagtg     2121

agtttcaaca tttttaaagt tttcaaaaag ccatcggaat gttaaattaa tgtaaaggga     2181

acagctaatc tagaccaaag aatggtattt tcacttttct ttgtaacatt gaatggtttg     2241

aagtactcaa aatctgttac gctaaacttt tgattcttta acacaattat ttttaaacac     2301

tggcattttc caaaactgtg gcagctaact ttttaaaatc tcaaatgaca tgcagtgtga     2361

gtagaaggaa gtcaacaata tgtggggaga gcactcggtt gtctttactt ttaaaagtaa     2421

tacttggtgc taagaatttc aggattattg tatttacgtt caaatgaaga tggcttttgt     2481

acttcctgtg gacatgtagt aatgtctata ttggctcata aaactaacct gaaaaacaaa     2541

taaatgcttt ggaaatgttt cagttgcttt agaaacatta gtgcctgcct ggatcccctt     2601

agttttgaaa tatttgccat tgttgtttaa atacctatca ctgtggtaga gcttgcattg     2661

atcttttcca caagtattaa actgccaaaa tgtgaatatg caaagccttt ctgaatctat     2721

aataatggta cttctactgg ggagagtgta atattttgga ctgctgtttt ccattaatga     2781

ggagagcaac aggcccctga ttatacagtt ccaaagtaat aagatgttaa ttgtaattca     2841

gccagaaagt acatgtctcc cattgggagg atttggtgtt aaataccaaa ctgctagccc     2901

tagtattatg gagatgaaca tgatgatgta acttgtaata gcagaatagt taatgaatga     2961

aactagttct tataatttat ctttatttaa aagcttagcc tgccttaaaa ctagagatca     3021

actttctcag ctgcaaaagc ttctagtctt tcaagaagtt catactttat gaaattgcac     3081

agtaagcatt tatttttcag accatttttg aacatcactc ctaaattaat aaagtattcc     3141

tctgttgctt tagtatttat tacaataaaa agggtttgaa atatagctgt tctttatgca     3201

taaaacaccc agctaggacc attactgcca gagaaaaaaa tcgtattgaa tggccatttc     3261

cctacttata agatgtctca atctgaattt atttggctac actaaagaat gcagtatatt     3321

tagttttcca tttgcatgat gtttgtgtgc tatagatgat attttaaatt gaaaagtttg     3381

ttttaaatta tttttacagt gaagactgtt ttcagctctt tttatattgt acatagtctt     3441

ttatgtaatt tactggcata tgttttgtag actgtttaat gactggatat cttccttcaa     3501

cttttgaaat acaaaaccag tgttttttac ttgtacactg ttttaaagtc tattaaaatt     3561

gtcatttgac ttttttctgt taacttaaaa aaaaaaaaaa aaa                       3604


<210>  4
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe Lys 
1               5                   10                  15      


Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys His 
            20                  25                  30          


Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn Tyr 
        35                  40                  45              


Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg Ile 
    50                  55                  60                  


Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys Lys 
65                  70                  75                  80  


Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln Val 
                85                  90                  95      


Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile Met 
            100                 105                 110         


Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe His 
        115                 120                 125             


Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val Ile 
    130                 135                 140                 


Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser Ile 
145                 150                 155                 160 


Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro His 
                165                 170                 175     


Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile Asn 
            180                 185                 190         


Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys Asn 
        195                 200                 205             


Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Thr Gln Lys 
    210                 215                 220                 


Glu Leu Ala Tyr Leu Ser Glu Leu Pro Pro Thr Pro Leu His Val Ser 
225                 230                 235                 240 


Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser Pro Pro Asp Ser Ser Val 
                245                 250                 255     


Ile Val Thr Leu Leu Asp Gln Ala Ala Lys Ser Asn Asp Asp Leu Asp 
            260                 265                 270         


Val Ser Glu Ser Lys Gly Cys Met Glu Glu Lys Pro Gln Glu Val Gln 
        275                 280                 285             


Thr Ser Arg Asn Val Glu Ser Ile Ala Glu Gln Met Glu Asn Pro Asp 
    290                 295                 300                 


Leu Lys Asn Val Gly Ser Ser Thr Gly Glu Lys Asn Glu Arg Thr Ser 
305                 310                 315                 320 


Val Ala Gly Thr Val Arg Lys Cys Trp Pro Asn Arg Val Ala Lys Glu 
                325                 330                 335     


Gln Ile Ser Arg Arg Leu Asp Gly Asn Gln Tyr Leu Phe Leu Pro Pro 
            340                 345                 350         


Asn Arg Tyr Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp 
        355                 360                 365             


Asp Val Leu Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr 
    370                 375                 380                 


Cys Gln Ser Pro Ser Leu Glu Glu Pro Met Glu Asp Glu Ser Glu Ile 
385                 390                 395                 400 


Glu Glu Phe Tyr Asn Gly Leu Glu Asp Glu Pro Asp Val Pro Glu Arg 
                405                 410                 415     


Ala Gly Gly Ala Gly Phe Gly Thr Asp Gly Asp Asp Gln Glu Ala Ile 
            420                 425                 430         


Asn Glu Ala Ile Ser Val Lys Gln Glu Val Thr Asp Met Asn Tyr Pro 
        435                 440                 445             


Ser Asn Lys Ser 
    450         


<210>  5
<211>  3393
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (246)..(1580)

<400>  5
gtgtctgttt catgtggaat acctgacttc aggtcaaggg atggtattta tgctcgcctt       60

gctgtagact tcccagatct tccagatcct caagcgatgt ttgatattga atatttcaga      120

aaagatccaa gaccattctt caagtttgca aagaagaaac agcattgaag cattatttgg      180

ggggaaaaac acacacacaa aatccagcaa ctcagcattc atgagcaact ctatactata      240

ccagt atg tgc ctg tgc agt gga agg aaa aca att ttg gaa ata tat cct      290
      Met Cys Leu Cys Ser Gly Arg Lys Thr Ile Leu Glu Ile Tyr Pro         
      1               5                   10                  15          

gga caa ttc cag cca tct ctc tgt cac aaa ttc ata gcc ttg tca gat        338
Gly Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp           
                20                  25                  30                

aag gaa gga aaa cta ctt cgc aac tat acc cag aac ata gac acg ctg        386
Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu           
            35                  40                  45                    

gaa cag gtt gcg gga atc caa agg ata att cag tgt cat ggt tcc ttt        434
Glu Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe           
        50                  55                  60                        

gca aca gca tct tgc ctg att tgt aaa tac aaa gtt gac tgt gaa gct        482
Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala           
    65                  70                  75                            

gta cga gga gat att ttt aat cag gta gtt cct cga tgt cct agg tgc        530
Val Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys           
80                  85                  90                  95            

cca gct gat gaa ccg ctt gct atc atg aaa cca gag att gtg ttt ttt        578
Pro Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe           
                100                 105                 110               

ggt gaa aat tta cca gaa cag ttt cat aga gcc atg aag tat gac aaa        626
Gly Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys           
            115                 120                 125                   

gat gaa gtt gac ctc ctc att gtt att ggg tct tcc ctc aaa gta aga        674
Asp Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg           
        130                 135                 140                       

cca gta gca cta att cca agt tcc ata ccc cat gaa gtg cct cag ata        722
Pro Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile           
    145                 150                 155                           

tta att aat aga gaa cct ttg cct cat ctg cat ttt gat gta gag ctt        770
Leu Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu           
160                 165                 170                 175           

ctt gga gac tgt gat gtc ata att aat gaa ttg tgt cat agg tta ggt        818
Leu Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly           
                180                 185                 190               

ggt gaa tat gcc aaa ctt tgc tgt aac cct gta aag ctt tca gaa att        866
Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile           
            195                 200                 205                   

act gaa aaa cct cca cga aca caa aaa gaa ttg gct tat ttg tca gag        914
Thr Glu Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu           
        210                 215                 220                       

ttg cca ccc aca cct ctt cat gtt tca gaa gac tca agt tca cca gaa        962
Leu Pro Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu           
    225                 230                 235                           

aga act tca cca cca gat tct tca gtg att gtc aca ctt tta gac caa       1010
Arg Thr Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln           
240                 245                 250                 255           

gca gct aag agt aat gat gat tta gat gtg tct gaa tca aaa ggt tgt       1058
Ala Ala Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys           
                260                 265                 270               

atg gaa gaa aaa cca cag gaa gta caa act tct agg aat gtt gaa agt       1106
Met Glu Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser           
            275                 280                 285                   

att gct gaa cag atg gaa aat ccg gat ttg aag aat gtt ggt tct agt       1154
Ile Ala Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser           
        290                 295                 300                       

act ggg gag aaa aat gaa aga act tca gtg gct gga aca gtg aga aaa       1202
Thr Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys           
    305                 310                 315                           

tgc tgg cct aat aga gtg gca aag gag cag att agt agg cgg ctt gat       1250
Cys Trp Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp           
320                 325                 330                 335           

ggt aat cag tat ctg ttt ttg cca cca aat cgt tac att ttc cat ggc       1298
Gly Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly           
                340                 345                 350               

gct gag gta tat tca gac tct gaa gat gac gtc tta tcc tct agt tct       1346
Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser           
            355                 360                 365                   

tgt ggc agt aac agt gat agt ggg aca tgc cag agt cca agt tta gaa       1394
Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu           
        370                 375                 380                       

gaa ccc atg gag gat gaa agt gaa att gaa gaa ttc tac aat ggc tta       1442
Glu Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu           
    385                 390                 395                           

gaa gat gag cct gat gtt cca gag aga gct gga gga gct gga ttt ggg       1490
Glu Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly           
400                 405                 410                 415           

act gat gga gat gat caa gag gca att aat gaa gct ata tct gtg aaa       1538
Thr Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys           
                420                 425                 430               

cag gaa gta aca gac atg aac tat cca tca aac aaa tca tag               1580
Gln Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser                       
            435                 440                                       

tgtaataatt gtgcaggtac aggaattgtt ccaccagcat taggaacttt agcatgtcaa     1640

aatgaatgtt tacttgtgaa ctcgatagag caaggaaacc agaaaggtgt aatatttata     1700

ggttggtaaa atagattgtt tttcatggat aatttttaac ttcattattt ctgtacttgt     1760

acaaactcaa cactaacttt ttttttttta aaaaaaaaaa ggtactaagt atcttcaatc     1820

agctgttggt caagactaac tttcttttaa aggttcattt gtatgataaa ttcatatgtg     1880

tatatataat tttttttgtt ttgtctagtg agtttcaaca tttttaaagt tttcaaaaag     1940

ccatcggaat gttaaattaa tgtaaaggga acagctaatc tagaccaaag aatggtattt     2000

tcacttttct ttgtaacatt gaatggtttg aagtactcaa aatctgttac gctaaacttt     2060

tgattcttta acacaattat ttttaaacac tggcattttc caaaactgtg gcagctaact     2120

ttttaaaatc tcaaatgaca tgcagtgtga gtagaaggaa gtcaacaata tgtggggaga     2180

gcactcggtt gtctttactt ttaaaagtaa tacttggtgc taagaatttc aggattattg     2240

tatttacgtt caaatgaaga tggcttttgt acttcctgtg gacatgtagt aatgtctata     2300

ttggctcata aaactaacct gaaaaacaaa taaatgcttt ggaaatgttt cagttgcttt     2360

agaaacatta gtgcctgcct ggatcccctt agttttgaaa tatttgccat tgttgtttaa     2420

atacctatca ctgtggtaga gcttgcattg atcttttcca caagtattaa actgccaaaa     2480

tgtgaatatg caaagccttt ctgaatctat aataatggta cttctactgg ggagagtgta     2540

atattttgga ctgctgtttt ccattaatga ggagagcaac aggcccctga ttatacagtt     2600

ccaaagtaat aagatgttaa ttgtaattca gccagaaagt acatgtctcc cattgggagg     2660

atttggtgtt aaataccaaa ctgctagccc tagtattatg gagatgaaca tgatgatgta     2720

acttgtaata gcagaatagt taatgaatga aactagttct tataatttat ctttatttaa     2780

aagcttagcc tgccttaaaa ctagagatca actttctcag ctgcaaaagc ttctagtctt     2840

tcaagaagtt catactttat gaaattgcac agtaagcatt tatttttcag accatttttg     2900

aacatcactc ctaaattaat aaagtattcc tctgttgctt tagtatttat tacaataaaa     2960

agggtttgaa atatagctgt tctttatgca taaaacaccc agctaggacc attactgcca     3020

gagaaaaaaa tcgtattgaa tggccatttc cctacttata agatgtctca atctgaattt     3080

atttggctac actaaagaat gcagtatatt tagttttcca tttgcatgat gtttgtgtgc     3140

tatagatgat attttaaatt gaaaagtttg ttttaaatta tttttacagt gaagactgtt     3200

ttcagctctt tttatattgt acatagtctt ttatgtaatt tactggcata tgttttgtag     3260

actgtttaat gactggatat cttccttcaa cttttgaaat acaaaaccag tgttttttac     3320

ttgtacactg ttttaaagtc tattaaaatt gtcatttgac ttttttctgt taacttaaaa     3380

aaaaaaaaaa aaa                                                        3393


<210>  6
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Leu Cys Ser Gly Arg Lys Thr Ile Leu Glu Ile Tyr Pro Gly 
1               5                   10                  15      


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
            20                  25                  30          


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
        35                  40                  45              


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
    50                  55                  60                  


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
65                  70                  75                  80  


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
                85                  90                  95      


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
            100                 105                 110         


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
        115                 120                 125             


Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro 
    130                 135                 140                 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
145                 150                 155                 160 


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
                165                 170                 175     


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
            180                 185                 190         


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
        195                 200                 205             


Glu Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu 
    210                 215                 220                 


Pro Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg 
225                 230                 235                 240 


Thr Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala 
                245                 250                 255     


Ala Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met 
            260                 265                 270         


Glu Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile 
        275                 280                 285             


Ala Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr 
    290                 295                 300                 


Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys 
305                 310                 315                 320 


Trp Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly 
                325                 330                 335     


Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala 
            340                 345                 350         


Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys 
        355                 360                 365             


Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu 
    370                 375                 380                 


Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu 
385                 390                 395                 400 


Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr 
                405                 410                 415     


Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln 
            420                 425                 430         


Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
        435                 440                 


<210>  7
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  7
ggccagctgt gagtgtttct ttggcagtgt cttagctggt tgttgtgagc aatagtaagg       60

aagcaatcag caagtatact gccctagaag tgctgcacgt tgtggggccc                 110


<210>  8
<211>  102
<212>  DNA
<213>  Mus musculus

<400>  8
ccagctgtga gtaattcttt ggcagtgtct tagctggttg ttgtgagtat tagctaagga       60

agcaatcagc aagtatactg ccctagaagt gctgcacatt gt                         102


<210>  9
<211>  102
<212>  DNA
<213>  Rattus norvegicus

<400>  9
ccggctgtga gtaattcttt ggcagtgtct tagctggttg ttgtgagtat tagctaagga       60

agcaatcagc aagtatactg ccctagaagt gctgcacgtt gt                         102


<210>  10
<211>  66
<212>  DNA
<213>  Canis familiaris

<400>  10
tggcagtgtc ttagctggtt gttgtgagta atagtgaagg aagcaatcag caagtatact       60

gcccta                                                                  66


<210>  11
<211>  91
<212>  DNA
<213>  Homo sapiens

<400>  11
ctgtgtgtga tgagctggca gtgtattgtt agctggttga atatgtgaat ggcatcggct       60

aacatgcaac tgctgtctta ttgcatatac a                                      91


<210>  12
<211>  91
<212>  DNA
<213>  Mus musculus

<400>  12
ctgtgtgtga tggcttggca gtgtattgtt agctggttga gtatgtgagc ggcaccagct       60

aacatgcgac tgctctccta ttgcacacac a                                      91


<210>  13
<211>  91
<212>  DNA
<213>  Rattus norvegicus

<400>  13
ctgtgtgcga tgggttggca gtgtattgtt agctggttga gtatgtaaaa ggcaccagct       60

aacatgcaac tgctctccta ttgcacatac a                                      91


<210>  14
<211>  91
<212>  DNA
<213>  Canis familiaris

<400>  14
ccgtgtgtga tgggttggca gtgtattgtt agctggttga atatatgaat ggcatcagct       60

aacatgcaac tgctatctta ttgcatatac a                                      91


<210>  15
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  15
tgacctgaat caggtaggca gtgtattgtt agctggctgc ttgggtcaag tcagcagcca       60

caactaccct gccacttgct tctggataaa ttcttct                                97


<210>  16
<211>  80
<212>  DNA
<213>  Mus musculus

<400>  16
agactcgggt aggcagtgtt gttagctggc tgcgttgggt caggccagca gccacagcta       60

ccctgccact tccttctggc                                                   80


<210>  17
<211>  129
<212>  DNA
<213>  Canis familiaris

<400>  17
gccatgaaac gtagccgtga cctgagtcag gtaggcagtg tattgttagc tggctgcttt       60

gggtcaatct ggcagccacc actaccctgc cacttgcttc tggacaaatt cttctcatta      120

acaggctgc                                                              129


<210>  18
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  18
gctgggatgt gtcaggtagg cagtgtattg ctagcggctg ttaatgattt taacagttgc       60

tagttgcact cctctctgtt gcattcagaa gc                                     92


<210>  19
<211>  109
<212>  DNA
<213>  Mus musculus

<400>  19
aggatgaagt gtgggtgtgt caggcaggca gtgcattgct agctggctgt tagaacttta       60

tcccaacagt tgctagctgc actaccctct gctgcactca gaagcatgc                  109


<210>  20
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  20
ccgggcccct gtgagcatct taccggacag tgctggattt cccagcttga ctctaacact       60

gtctggtaac gatgttcaaa ggtgacccgc                                        90


<210>  21
<211>  90
<212>  DNA
<213>  Mus musculus

<400>  21
ctgggcctct gtgggcatct taccggacag tgctggattt cttggcttga ctctaacact       60

gtctggtaac gatgttcaaa ggtgacccac                                        90


<210>  22
<211>  89
<212>  DNA
<213>  Rattus norvegicus

<400>  22
ctgggcctct gtgggcatct taccggacag tgctggattt cttggcttga ctctaacact       60

gtctggtaac gatgttcaaa ggtgaccca                                         89


<210>  23
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  23
ccagctcggg cagccgtggc catcttactg ggcagcattg gatggagtca ggtctctaat       60

actgcctggt aatgatgacg gcggagccct gcacg                                  95


<210>  24
<211>  70
<212>  DNA
<213>  Mus musculus

<400>  24
gccgtggcca tcttactggg cagcattgga tagtgtctga tctctaatac tgcctggtaa       60

tgatgacggc                                                              70


<210>  25
<211>  95
<212>  DNA
<213>  Rattus norvegicus

<400>  25
ccaacttggg cagccgtggc catcttactg ggcagcattg gatagtgtct gatctctaat       60

actgcctggt aatgatgacg gcggagccct gcacg                                  95


<210>  26
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  26
ccctcgtctt acccagcagt gtttgggtgc ggttgggagt ctctaatact gccgggtaat       60

gatggagg                                                                68


<210>  27
<211>  69
<212>  DNA
<213>  Mus musculus

<400>  27
ccctcgtctt acccagcagt gtttgggtgc tggttgggag tctctaatac tgccgggtaa       60

tgatggagg                                                               69


<210>  28
<211>  69
<212>  DNA
<213>  Rattus norvegicus

<400>  28
ccctcgtctt acccagcagt gtttgggtgc tggttgggag tctctaatac tgccgggtaa       60

tgatggagg                                                               69


