                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Lavie, Arnon
       Nguyen, Hien Anh
 
<120>  L-Asparaginase Variants and Fusion Proteins With Reduced 
       L-Glutaminase Activity and Enhanced Stability

<130>  UIC0062WO

<150>  US 62/446,026
<151>  2017-01-13

<150>  US 62/347,376
<151>  2016-06-08

<150>  US 62/301,806
<151>  2016-03-01

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  1

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Glu Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  2
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  3
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Asn Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  4
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ile Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  5
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Gln Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  6
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ile Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Gln Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  7
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ile Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Asn Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  8
<211>  325
<212>  PRT
<213>  Erwinia carotovora

<400>  8

Met Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile Ala Gly 
1               5                   10                  15      


Ser Ala Ala Ala Asn Thr Gln Thr Thr Gly Tyr Lys Ala Gly Ala Leu 
            20                  25                  30          


Gly Val Glu Thr Leu Ile Gln Ala Val Pro Glu Leu Lys Thr Leu Ala 
        35                  40                  45              


Asn Ile Lys Gly Glu Gln Val Ala Ser Ile Gly Ser Glu Asn Met Thr 
    50                  55                  60                  


Ser Asp Val Leu Leu Thr Leu Ser Lys Arg Val Asn Glu Leu Leu Ala 
65                  70                  75                  80  


Arg Ser Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp Thr Leu 
                85                  90                  95      


Asp Glu Ser Pro Tyr Phe Leu Asn Leu Thr Val Lys Ser Asp Lys Pro 
            100                 105                 110         


Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser Ala Asp 
        115                 120                 125             


Gly Pro Met Asn Leu Tyr Gly Ala Val Lys Val Ala Ala Asp Lys Asn 
    130                 135                 140                 


Ser Arg Gly Arg Gly Val Leu Val Val Leu Asn Asp Arg Ile Gly Ser 
145                 150                 155                 160 


Ala Arg Phe Ile Ser Lys Thr Asn Ala Ser Thr Leu Asp Thr Phe Lys 
                165                 170                 175     


Ala Pro Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asp Lys Ile Tyr 
            180                 185                 190         


Tyr Gln Thr Arg Leu Asp Lys Val His Thr Thr Arg Ser Val Phe Asp 
        195                 200                 205             


Val Thr Asn Val Asp Lys Leu Pro Ala Val Asp Ile Ile Tyr Gly Tyr 
    210                 215                 220                 


Gln Asp Asp Pro Glu Tyr Met Tyr Asp Ala Ser Ile Lys His Gly Val 
225                 230                 235                 240 


Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val Ser Lys Arg 
                245                 250                 255     


Gly Asp Ala Gly Ile Arg Lys Ala Glu Ser Lys Gly Ile Val Val Val 
            260                 265                 270         


Arg Ser Ser Arg Thr Gly Ser Gly Ile Val Pro Pro Asp Ala Gly Gln 
        275                 280                 285             


Pro Gly Leu Val Ala Asp Ser Leu Ser Pro Ala Lys Ser Arg Ile Leu 
    290                 295                 300                 


Leu Met Leu Ala Leu Thr Lys Thr Thr Asn Pro Ala Val Ile Gln Asp 
305                 310                 315                 320 


Tyr Phe His Ala Tyr 
                325 


<210>  9
<211>  327
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Leu Pro Asn Ile Thr Ile Leu Ala Thr Gly Gly Thr Ile Ala Gly 
1               5                   10                  15      


Gly Gly Asp Ser Ala Thr Lys Ser Asn Tyr Thr Val Gly Lys Val Gly 
            20                  25                  30          


Val Glu Asn Leu Val Asn Ala Val Pro Gln Leu Lys Asp Ile Ala Asn 
        35                  40                  45              


Val Lys Gly Glu Gln Val Val Asn Ile Gly Ser Gln Asp Met Asn Asp 
    50                  55                  60                  


Asn Val Trp Leu Thr Leu Ala Lys Lys Ile Asn Thr Asp Cys Asp Lys 
65                  70                  75                  80  


Thr Asp Gly Phe Val Ile Thr His Gly Thr Asp Thr Met Glu Glu Thr 
                85                  90                  95      


Ala Tyr Phe Leu Asp Leu Thr Val Lys Cys Asp Lys Pro Val Val Met 
            100                 105                 110         


Val Gly Ala Met Arg Pro Ser Thr Ser Met Ser Ala Asp Gly Pro Phe 
        115                 120                 125             


Asn Leu Tyr Asn Ala Val Val Thr Ala Ala Asp Lys Ala Ser Ala Asn 
    130                 135                 140                 


Arg Gly Val Leu Val Val Met Asn Asp Thr Val Leu Asp Gly Arg Asp 
145                 150                 155                 160 


Val Thr Lys Thr Asn Thr Thr Asp Val Ala Thr Phe Lys Ser Val Asn 
                165                 170                 175     


Tyr Gly Pro Leu Gly Tyr Ile His Asn Gly Lys Ile Asp Tyr Gln Arg 
            180                 185                 190         


Thr Pro Ala Arg Lys His Thr Ser Asp Thr Pro Phe Asp Val Ser Lys 
        195                 200                 205             


Leu Asn Glu Leu Pro Lys Val Gly Ile Val Tyr Asn Tyr Ala Asn Ala 
    210                 215                 220                 


Ser Asp Leu Pro Ala Lys Ala Leu Val Asp Ala Gly Tyr Asp Gly Ile 
225                 230                 235                 240 


Val Ser Ala Gly Val Gly Asn Gly Asn Leu Tyr Lys Ser Val Phe Asp 
                245                 250                 255     


Thr Leu Ala Thr Ala Ala Lys Thr Gly Thr Ala Val Val Arg Ser Ser 
            260                 265                 270         


Arg Val Pro Thr Gly Ala Thr Thr Gln Asp Ala Glu Val Asp Asp Ala 
        275                 280                 285             


Lys Tyr Gly Phe Val Ala Ser Gly Thr Leu Asn Pro Gln Lys Ala Arg 
    290                 295                 300                 


Val Leu Leu Gln Leu Ala Leu Thr Gln Thr Lys Asp Pro Gln Gln Ile 
305                 310                 315                 320 


Gln Gln Ile Phe Asn Gln Tyr 
                325         


<210>  10
<211>  330
<212>  PRT
<213>  Helicobacter pylori

<400>  10

Met Ala Gln Asn Leu Pro Thr Ile Ala Leu Leu Ala Thr Gly Gly Thr 
1               5                   10                  15      


Ile Ala Gly Ser Gly Ala Ser Ala Ser Leu Gly Ser Tyr Lys Ser Gly 
            20                  25                  30          


Glu Leu Gly Ile Lys Glu Leu Leu Lys Ala Ile Pro Ser Leu Asn Arg 
        35                  40                  45              


Leu Ala Arg Ile Gln Gly Glu Gln Ile Ser Asn Ile Gly Ser Gln Asp 
    50                  55                  60                  


Met Asn Glu Glu Val Trp Phe Lys Leu Ala Lys Arg Ala Gln Glu Leu 
65                  70                  75                  80  


Leu Asp Asp Ser Arg Ile Gln Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Leu Glu Glu Ser Ala Tyr Phe Leu Asn Leu Val Leu Arg Ser Thr 
            100                 105                 110         


Lys Pro Val Val Leu Val Gly Ala Met Arg Asn Ala Ala Ser Leu Ser 
        115                 120                 125             


Ala Asp Gly Ala Leu Asn Leu Tyr Asn Ala Val Ser Val Ala Leu Asn 
    130                 135                 140                 


Glu Lys Ser Ala Asn Lys Gly Val Leu Val Val Met Asp Asp Asn Ile 
145                 150                 155                 160 


Phe Ser Ala Arg Glu Val Ile Lys Thr His Thr Thr His Thr Ser Thr 
                165                 170                 175     


Phe Lys Ala Leu Asn Ser Gly Ala Ile Gly Ser Val Tyr Tyr Gly Lys 
            180                 185                 190         


Thr Arg Tyr Tyr Met Gln Pro Leu Arg Lys His Thr Thr Glu Ser Glu 
        195                 200                 205             


Phe Ser Leu Ser Gln Leu Lys Thr Pro Leu Pro Lys Val Asp Ile Ile 
    210                 215                 220                 


Tyr Thr His Ala Gly Met Thr Pro Asp Leu Phe Gln Ala Ser Leu Asn 
225                 230                 235                 240 


Ser His Ala Lys Gly Val Val Ile Ala Gly Val Gly Asn Gly Asn Val 
                245                 250                 255     


Ser Ala Gly Phe Leu Lys Ala Met Gln Glu Ala Ser Gln Met Gly Val 
            260                 265                 270         


Val Ile Val Arg Ser Ser Arg Val Asn Ser Gly Glu Ile Thr Ser Gly 
        275                 280                 285             


Glu Ile Asp Asp Lys Ala Phe Ile Thr Ser Asp Asn Leu Asn Pro Gln 
    290                 295                 300                 


Lys Ala Arg Val Leu Leu Gln Leu Ala Leu Thr Lys Thr Asn Asn Lys 
305                 310                 315                 320 


Glu Lys Ile Gln Glu Met Phe Glu Glu Tyr 
                325                 330 


<210>  11
<211>  330
<212>  PRT
<213>  Wolinella succinogenes

<400>  11

Met Ala Lys Pro Gln Val Thr Ile Leu Ala Thr Gly Gly Thr Ile Ala 
1               5                   10                  15      


Gly Ser Gly Glu Ser Ser Val Lys Ser Ser Tyr Ser Ala Gly Ala Val 
            20                  25                  30          


Thr Val Asp Lys Leu Leu Ala Ala Val Pro Ala Ile Asn Asp Leu Ala 
        35                  40                  45              


Thr Ile Lys Gly Glu Gln Ile Ser Ser Ile Gly Ser Gln Glu Met Thr 
    50                  55                  60                  


Gly Lys Val Trp Leu Lys Leu Ala Lys Arg Val Asn Glu Leu Leu Ala 
65                  70                  75                  80  


Gln Lys Glu Thr Glu Ala Val Ile Ile Thr His Gly Thr Asp Thr Met 
                85                  90                  95      


Glu Glu Thr Ala Phe Phe Leu Asn Leu Thr Val Lys Ser Gln Lys Pro 
            100                 105                 110         


Val Val Leu Val Gly Ala Met Arg Ser Gly Ser Ser Met Ser Ala Asp 
        115                 120                 125             


Gly Pro Met Asn Leu Tyr Asn Ala Val Asn Val Ala Ile Asn Lys Ala 
    130                 135                 140                 


Ser Thr Asn Lys Gly Val Val Ile Val Met Asn Asp Glu Ile His Ala 
145                 150                 155                 160 


Ala Arg Glu Ala Thr Lys Leu Asn Thr Thr Ala Val Asn Ala Phe Ala 
                165                 170                 175     


Ser Pro Asn Thr Gly Lys Ile Gly Thr Val Tyr Tyr Gly Lys Val Glu 
            180                 185                 190         


Tyr Phe Thr Gln Ser Val Arg Pro His Thr Leu Ala Ser Glu Phe Asp 
        195                 200                 205             


Ile Ser Lys Ile Glu Glu Leu Pro Arg Val Asp Ile Leu Tyr Ala His 
    210                 215                 220                 


Pro Asp Asp Thr Asp Val Leu Val Asn Ala Ala Leu Gln Ala Gly Ala 
225                 230                 235                 240 


Lys Gly Ile Ile His Ala Gly Met Gly Asn Gly Asn Pro Phe Pro Leu 
                245                 250                 255     


Thr Gln Asn Ala Leu Glu Lys Ala Ala Lys Ser Gly Val Val Val Ala 
            260                 265                 270         


Arg Ser Ser Arg Val Gly Ser Gly Ser Thr Thr Gln Glu Ala Glu Val 
        275                 280                 285             


Asp Asp Lys Lys Leu Gly Phe Val Ala Thr Glu Ser Leu Asn Pro Gln 
    290                 295                 300                 


Lys Ala Arg Val Leu Leu Met Leu Ala Leu Thr Lys Thr Ser Asp Arg 
305                 310                 315                 320 


Glu Ala Ile Gln Lys Ile Phe Ser Thr Tyr 
                325                 330 


<210>  12
<211>  353
<212>  PRT
<213>  Cavia porcellus

<400>  12

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp 
    


<210>  13
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  13

Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210>  14
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  14

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  15

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15  


<210>  16
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly Leu 
        275                 280         


<210>  17
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly 
                165         


<210>  18
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Gly Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly 
            500             


<210>  19
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(15)
<223>  Residue may be present or absent

<400>  19

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  20
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(24)
<223>  Residue may be present or absent.

<400>  20

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  21
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  21

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  22
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Gly Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
        515                 520                 525             


Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
    530                 535                 540                 


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ile Gly 
545                 550                 555                 560 


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
                565                 570                 575     


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
            580                 585                 590         


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
        595                 600                 605             


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
    610                 615                 620                 


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
625                 630                 635                 640 


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
                645                 650                 655     


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
            660                 665                 670         


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
        675                 680                 685             


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
    690                 695                 700                 


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
705                 710                 715                 720 


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
                725                 730                 735     


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
            740                 745                 750         


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
        755                 760                 765             


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Gln Val Ser 
    770                 775                 780                 


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
785                 790                 795                 800 


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
                805                 810                 815     


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
            820                 825                 830         


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
        835                 840                 845             


Gln Glu Tyr Phe His Thr Tyr 
    850                 855 


<210>  23
<211>  967
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Gly Ser Ser His His His His His His Gly Thr Met Ser Asp Ser 
1               5                   10                  15      


Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro 
            20                  25                  30          


Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe 
        35                  40                  45              


Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe 
    50                  55                  60                  


Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp 
65                  70                  75                  80  


Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu 
                85                  90                  95      


Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Leu Glu 
            100                 105                 110         


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
        115                 120                 125             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    130                 135                 140                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
145                 150                 155                 160 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                165                 170                 175     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            180                 185                 190         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        195                 200                 205             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    210                 215                 220                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
225                 230                 235                 240 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                245                 250                 255     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            260                 265                 270         


Phe Gly Ala Phe Leu Val Gly Gly Arg Glu Arg Gly Pro Gln Arg Val 
        275                 280                 285             


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
    290                 295                 300                 


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
305                 310                 315                 320 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
                325                 330                 335     


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
            340                 345                 350         


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
        355                 360                 365             


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
    370                 375                 380                 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
385                 390                 395                 400 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
                405                 410                 415     


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
            420                 425                 430         


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 
        435                 440                 445             


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
    450                 455                 460                 


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
465                 470                 475                 480 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
                485                 490                 495     


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
            500                 505                 510         


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
        515                 520                 525             


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
    530                 535                 540                 


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
545                 550                 555                 560 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
                565                 570                 575     


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
            580                 585                 590         


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
        595                 600                 605             


Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
625                 630                 635                 640 


Met Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
                645                 650                 655     


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ile Gly 
            660                 665                 670         


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        675                 680                 685             


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Gln Asn 
    690                 695                 700                 


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
705                 710                 715                 720 


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                725                 730                 735     


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            740                 745                 750         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        755                 760                 765             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    770                 775                 780                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
785                 790                 795                 800 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                805                 810                 815     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            820                 825                 830         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        835                 840                 845             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    850                 855                 860                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
865                 870                 875                 880 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Gln Val Ser 
                885                 890                 895     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            900                 905                 910         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        915                 920                 925             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    930                 935                 940                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
945                 950                 955                 960 


Gln Glu Tyr Phe His Thr Tyr 
                965         


<210>  24
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
ggcggtggca gcggtggagg aggctctggt ggaggcggta gcggaggcgg agggtcg          57


<210>  25
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
cgaatgcatc tagatctcga gcgtgagcgt g                                      31


<210>  26
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
cacgctcacg ctcgagatct agatgcattc g                                      31


<210>  27
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gaacagattg gtggtctcga gggaggaatt ccatatggat aaactg                      46


<210>  28
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
cagtttatcc atatggaatt cctccctcga gaccaccaat ctgttc                      46


<210>  29
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
gcacgctata tcaccatgac gaacgcttcg acc                                    33


<210>  30
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
ggtcgaagcg ttcgtcatgg tgatatagcg tgc                                    33


<210>  31
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  31

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


