                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       University of Rijeka Faculty of Medicine
 
<120>  ANTIBODIES SPECIFIC TO HUMAN POLIOVIRUS RECEPTOR (PVR)

<130>  Yissum/0137 PCT

<150>  US 62/301727
<151>  2016-03-01

<150>  US 62/364924
<151>  2016-07-21

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  390
<212>  DNA
<213>  Mus musculus

<400>  1
gaggtgaagc tgcaggagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgcag cctcaggatt cgattttagt agatactgga tgacttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attcatccag atagcagtaa gataaactat      180

acgccatctc aaaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgttc      240

ctgcaaatga gcaaagtgag atttgaggac acagcccttt atttctgtgc aagacctgat      300

ggtaactaca atgctctgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaacgacac ccccatctgt ctatgtcgac                                       390


<210>  2
<211>  130
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Pro Asp Ser Ser Lys Ile Asn Tyr Thr Pro Ser Gln 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Phe Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Asn Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Val Asp 
    130 


<210>  3
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  3
ggattcgatt ttagtagata ctgg                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Phe Asp Phe Ser Arg Tyr Trp 
1               5               


<210>  5
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  5
gaaattcatc cagatagcag taagataaac tatacgccat ctcaa                       45


<210>  6
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Ile His Pro Asp Ser Ser Lys Ile Asn Tyr Thr Pro Ser Gln 
1               5                   10                  15  


<210>  7
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  7
cctgatggta actacaatgc tctggactac tgg                                    33


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Pro Asp Gly Asn Tyr Asn Ala Leu Asp Tyr Trp 
1               5                   10      


<210>  9
<211>  374
<212>  DNA
<213>  Mus musculus

<400>  9
ctgcaaccgg tgtacattcc gacattgtga tgactcagtc tcacaaattc atgtccacat       60

cagtgggaga cagggtcagc atcacctgca aggccagtca ggatgtgggt actgctgtaa      120

cctggtatca acagaaacca ggacaatctc ctaaactact gatttactgg gcatccaccc      180

ggcacactgg agtccctgat cgcttcacag gcagtgaatc tgggacagat ttcactctca      240

ccattagtga tgtgcaatct gaagacttgg caaattattt ctgtcagcaa tatagcaggt      300

atccgtacac gttcggaggg gggaccaagc tggaaataaa acgggccgat gctgcaccaa      360

ctgtatccgt cgac                                                        374


<210>  10
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  10

Ala Thr Gly Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
1               5                   10                  15      


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
            20                  25                  30          


Gln Asp Val Gly Thr Ala Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ser Glu Asp Leu Ala Asn Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Ser Arg Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Val Asp 
        115                 120                 


<210>  11
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  11
aaggccagtc aggatgtggg tactgctgta acc                                    33


<210>  12
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Thr 
1               5                   10      


<210>  13
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  13
tgggcatcca cccggcacac t                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  15
cagcaatata gcaggtatcc gtacacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Tyr Ser Arg Tyr Pro Tyr Thr 
1               5                   


<210>  17
<211>  526
<212>  DNA
<213>  Mus musculus

<400>  17
gaattcgagg tgaagctgca ggagtctgga cctgagctgg tgaagcctgg ggcttcagtg       60

aagatttcct gcaagacttc tggatacact ttcactgaat acaccatgca ctgggtgagg      120

cagagccatg gagagagcct tgagtggatt ggaggtattg atcctaacaa tggtggtact      180

aactacaacc agaacttcaa gggcaaggcc acattgactg tagacaagtc ctccagcaca      240

gcctacatgg agctccgcag cctgacatct gaggattctg cggtctatta ctgtgcagga      300

gtgattcctc tggagtactg ggggcaagga acctcagtca ccgtctcctc agccaaaacg      360

acacccccat ctgtctatgt cgaccatatg ggagagctcc caacgcgttg gatgcatagc      420

ttgagtattc tatagtgtca cctaaatagc ttggcgtaat catggtcata gctgtttcct      480

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccg                     526


<210>  18
<211>  144
<212>  PRT
<213>  Mus musculus

<400>  18

Glu Phe Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Glu Tyr Thr Met His Trp Val Arg Gln Ser His Gly Glu Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Gly Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln 
    50                  55                  60                  


Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Val Ile Pro Leu Glu Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Val Asp 
        115                 120                 125             


His Met Gly Glu Leu Pro Thr Arg Trp Met His Ser Leu Ser Ile Leu 
    130                 135                 140                 


<210>  19
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  19
ggatacactt tcactgaata caccatgcac                                        30


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Tyr Thr Phe Thr Glu Tyr Thr Met His 
1               5                   10  


<210>  21
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  21
ggtattgatc ctaacaatgg tggtactaac tacaaccaga acttcaaggg c                51


<210>  22
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  22

Gly Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


<210>  23
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  23
gtgattcctc tggagtac                                                     18


<210>  24
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  24

Val Ile Pro Leu Glu Tyr 
1               5       


<210>  25
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  25
gatattgtga tgacacagtc tcaaaaattc atgtccacat cagtaggaga cagagtcagc       60

gtcacctgca aggccagtca gaatgtgtat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagggg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagactattt ctgtcagcaa tataacagct atcctctcgc gttcggctcg      300

gggaccaagc tggagctgaa a                                                321


<210>  26
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  26

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Tyr Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Arg Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Val Asp 
        115             


<210>  27
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  27
aaggccagtc agaatgtgta tactaatgta gcc                                    33


<210>  28
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  28

Lys Ala Ser Gln Asn Val Tyr Thr Asn Val Ala 
1               5                   10      


<210>  29
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  29
tcggcatcct accggtacag g                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Ala Ser Tyr Arg Tyr Arg 
1               5           


<210>  31
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  31
cagcaatata acagctatcc tctcgcg                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Gln Tyr Asn Ser Tyr Pro Leu Ala 
1               5                   


<210>  33
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  33
caactgcagc agtctggagc tgagctgatg aagcctgggg cctcagtgaa gatttcctgc       60

aaggctactg gctacacatt cagtaactac tggattgagt ggataaaaca gaggcctgga      120

catggccttg agtggattgg agagattttt cctggaagtg gtcgtattaa cttcaatgag      180

aagttcaagg gcaaggccac attcactgca gacacatcct ccgacacaac ctacatgcaa      240

ctcagcagcc tgacatctgc ggactctgcc gtctattact gtgcaagaac gaagatctat      300

ggtaactcct ttgactactg gggccaaggc accactctca cagtc                      345


<210>  34
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val 
1               5                   10                  15      


Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp Ile 
            20                  25                  30          


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
        35                  40                  45              


Ile Phe Pro Gly Ser Gly Arg Ile Asn Phe Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asp Thr Thr Tyr Met Gln 
65                  70                  75                  80  


Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Thr Lys Ile Tyr Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val 
        115 


<210>  35
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  35
ggctacacat tcagtaacta ctggattgag                                        30


<210>  36
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  36

Gly Tyr Thr Phe Ser Asn Tyr Trp Ile Glu 
1               5                   10  


<210>  37
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  37
gagatttttc ctggaagtgg tcgtattaac ttcaatgaga agttcaaggg c                51


<210>  38
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  38

Glu Ile Phe Pro Gly Ser Gly Arg Ile Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  39
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  39
acgaagatct atggtaactc ctttgactac                                        30


<210>  40
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  40

Thr Lys Ile Tyr Gly Asn Ser Phe Asp Tyr 
1               5                   10  


<210>  41
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  41
gacatcgtga tgactcagtc tcacaaattc atgtccacat cagtaggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgggt actgctgtgg tctggtatca acagaaacca      120

ggacaatctc ctaaattatt gatttactgg gcatccagtc ggcacaatgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca cgattagtaa tgtgcagtct      240

gaagacttgt cagattattt ctgtcagcaa tatagcaggt atccactcac attcggggct      300

gggaccaagc tggagctgaa acgt                                             324


<210>  42
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  42

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Asn Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  43
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  43
aaggccagtc aggatgtggg tactgctgtg gtc                                    33


<210>  44
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  44

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Val 
1               5                   10      


<210>  45
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  45
tgggcatcca gtcggcacaa t                                                 21


<210>  46
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  46

Trp Ala Ser Ser Arg His Asn 
1               5           


<210>  47
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  47
cagcaatata gcaggtatcc actcaca                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Gln Tyr Ser Arg Tyr Pro Leu Thr 
1               5                   


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated chain

<400>  49

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Ala Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated chain

<400>  50

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Arg Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated chain

<400>  51

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Asp Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  52
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated chain

<400>  52

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Glu Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  53
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated chain

<400>  53

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Pro Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  54
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated chain

<400>  54

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  55
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is an amino acid residue selected from: Ala, Arg, Asp, Glu, 
       Pro and Thr

<400>  55

Trp Ala Ser Ser Arg His Xaa 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  56

Trp Ala Ser Ser Arg His Ala 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  57

Trp Ala Ser Ser Arg His Arg 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  58

Trp Ala Ser Ser Arg His Asp 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  59

Trp Ala Ser Ser Arg His Glu 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  60

Trp Ala Ser Ser Arg His Pro 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated CDR

<400>  61

Trp Ala Ser Ser Arg His Thr 
1               5           


<210>  62
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  62
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcacgctgg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  63
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  63
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcacagagg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  64
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  64
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcacgatgg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  65
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  65
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcacgaggg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  66
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  66
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcaccctgg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  67
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated polynucleotide

<400>  67
gacatcatga tgacccagtc tcacaaattc atgtctacat ctgtaggaga cagagtcaac       60

atcacttgca aggcgagtca ggatgtgggt actgctgtgg tctggtatca gcagaaacca      120

gggcaatctc ctaagttgct gatctattgg gcatccagtc ggcacactgg ggtcccagat      180

aggttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagatttgt cagattattt ctgccaacag tatagcagat accctctcac attcggggct      300

gggaccaagc tggagctcaa a                                                321


<210>  68
<211>  356
<212>  DNA
<213>  Mus musculus

<400>  68
gaggtgaagc ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgcag cctcaggatt cgattttagt agatactgga tgacttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attcatccag atagcagtaa gataaactat      180

acgccatctc aaaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgttc      240

ctgcaaatga gcaaagtgag atttgaggac acagcccttt atttctgtgc aagacctgat      300

ggtaactaca atgctctgga ctactggggt caaggaacct cagtcaccgt ctcctc          356


<210>  69
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  69

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Pro Asp Ser Ser Lys Ile Asn Tyr Thr Pro Ser Gln 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Phe Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Asn Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  70
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtgggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtaa cctggtatca acagaaacca      120

ggacaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtgaatc tgggacagat ttcactctca ccattagtga tgtgcaatct      240

gaagacttgg caaattattt ctgtcagcaa tatagcaggt atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  71
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  71

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asn Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  72
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatt       60

tcctgcaaga cttctggata cactttcact gaatacacca tgcactgggt gaagcagagc      120

catggagaga gccttgagtg gattggaggt attgatccta acaatggtgg tactaactac      180

aaccagaact tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggat tctgcggtct attactgtgc aggagtgatt      300

cctctggagt actgggggca aggaacctca gtcaccgtct cctca                      345


<210>  73
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  73

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Val Ile Pro Leu Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  74
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  74
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagagtcagc       60

gtcacctgca aggccagtca gaatgtgtat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagggg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagactattt ctgtcagcaa tataacagct atcctctcgc gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  75
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  75

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Tyr Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Arg Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  76
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  76
caggttcagt tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagatt       60

tcctgcaagg ctactggcta cacattcagt aactactgga ttgagtggat aaaacagagg      120

cctggacatg gccttgagtg gattggagag atttttcctg gaagtggtcg tattaacttc      180

aatgagaagt tcaagggcaa ggccacattc actgcagaca catcctccga cacaacctac      240

atgcaactca gcagcctgac atctgcggac tctgccgtct attactgtgc aagaacgaag      300

atctatggta actcctttga ctactggggc caaggcacca ctctcacagt ctcccca         357


<210>  77
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  77

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Phe Pro Gly Ser Gly Arg Ile Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asp Thr Thr Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Lys Ile Tyr Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Pro 
        115                 


<210>  78
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  78
gacattatga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgggt actgctgtgg tctggtatca acagaaacca      120

ggacaatctc ctaaattatt gatttactgg gcatccagtc ggcacaatgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca cgattagtaa tgtgcagtct      240

gaagacttgt cagattattt ctgtcagcaa tatagcaggt atccactcac attcggggct      300

gggaccaagc tggagctgaa a                                                321


<210>  79
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  79

Asp Ile Met Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Asn Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Ser Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  80
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  80

Arg Tyr Trp Met Thr 
1               5   


<210>  81
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  81

Glu Ile His Pro Asp Ser Ser Lys Ile Asn Tyr Thr Pro Ser Gln Lys 
1               5                   10                  15      


Asp 
    


<210>  82
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  82

Pro Asp Gly Asn Tyr Asn Ala Leu Asp Tyr 
1               5                   10  


<210>  83
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  83

Glu Tyr Thr Met His 
1               5   


<210>  84
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  84

Ser Asn Tyr Trp Ile Glu 
1               5       


<210>  85
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  85

Lys Ala Ser Gln Asp Val Gly Thr Ala Val 
1               5                   10  


<210>  86
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  86

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
145                 150                 155                 160 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
225                 230                 235                 240 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


