                         SEQUENCE LISTING

<110>  Apitope International NV
 
<120>  PEPTIDES

<130>  P106244PCT

<150>  GB 1603582.6
<151>  2016-03-01

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  1

Met Leu Thr Phe Leu His Glu Pro Ala Val Leu Phe Asn Leu Lys 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  2

Val Asn Pro Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  3

Pro His Ile Phe Ser Ile Ser Asp Asn Ala Tyr Gln Tyr Met Leu 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  4

Lys Arg Val Ile Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  5

Tyr His Ile Phe Tyr Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  6

Lys Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  7

Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser Tyr Ala 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  8

Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  9

Glu Ala Thr Leu Gln His Glu Ala Thr Ala Ala Ala Leu Arg Lys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope peptide

<400>  10

Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln 
1               5                   10                  15  


<210>  11
<211>  1939
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Asp Ala Gln Met Ala Asp Phe Gly Ala Ala Ala Gln Tyr Leu 
1               5                   10                  15      


Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp 
            20                  25                  30          


Ile Arg Thr Glu Cys Phe Val Pro Asp Asp Lys Glu Glu Phe Val Lys 
        35                  40                  45              


Ala Lys Ile Leu Ser Arg Glu Gly Gly Lys Val Ile Ala Glu Thr Glu 
    50                  55                  60                  


Asn Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Leu Gln Gln Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu 
                85                  90                  95      


His Glu Pro Ala Val Leu Phe Asn Leu Lys Glu Arg Tyr Ala Ala Trp 
            100                 105                 110         


Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr 
        115                 120                 125             


Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Ala Ala Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn 
145                 150                 155                 160 


Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile 
            180                 185                 190         


Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp Arg Gly Lys Lys Asp 
        195                 200                 205             


Asn Ala Asn Ala Asn Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala 
    210                 215                 220                 


Asn Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp 
225                 230                 235                 240 


Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr 
                245                 250                 255     


Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser 
            260                 265                 270         


Arg Val Ile Phe Gln Leu Lys Ala Glu Arg Asn Tyr His Ile Phe Tyr 
        275                 280                 285             


Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Val 
    290                 295                 300                 


Thr Asn Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu Val Ser 
305                 310                 315                 320 


Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Met Ala Thr Asp Ser Ala 
                325                 330                 335     


Phe Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Ala Gly Val Tyr Lys 
            340                 345                 350         


Leu Thr Gly Ala Ile Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys 
        355                 360                 365             


Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Asp Ala Asp Lys 
    370                 375                 380                 


Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu 
385                 390                 395                 400 


Cys His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln 
                405                 410                 415     


Ser Val Gln Gln Val Tyr Tyr Ser Ile Gly Ala Leu Ala Lys Ala Val 
            420                 425                 430         


Tyr Glu Lys Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu 
        435                 440                 445             


Glu Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala 
    450                 455                 460                 


Gly Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn 
465                 470                 475                 480 


Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val 
                485                 490                 495     


Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile 
            500                 505                 510         


Asp Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro 
        515                 520                 525             


Met Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala 
    530                 535                 540                 


Thr Asp Met Thr Phe Lys Ala Lys Leu Tyr Asp Asn His Leu Gly Lys 
545                 550                 555                 560 


Ser Asn Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Gln Glu Ala 
                565                 570                 575     


His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn Ile Leu 
            580                 585                 590         


Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Ala 
        595                 600                 605             


Leu Tyr Gln Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser 
    610                 615                 620                 


Tyr Ala Thr Ala Asp Thr Gly Asp Ser Gly Lys Ser Lys Gly Gly Lys 
625                 630                 635                 640 


Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn 
                645                 650                 655     


Leu Asn Lys Leu Met Thr Asn Leu Arg Thr Thr His Pro His Phe Val 
            660                 665                 670         


Arg Cys Ile Ile Pro Asn Glu Arg Lys Ala Pro Gly Val Met Asp Asn 
        675                 680                 685             


Pro Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile 
    690                 695                 700                 


Arg Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe 
705                 710                 715                 720 


Arg Gln Arg Tyr Arg Ile Leu Asn Pro Val Ala Ile Pro Glu Gly Gln 
                725                 730                 735     


Phe Ile Asp Ser Arg Lys Gly Thr Glu Lys Leu Leu Ser Ser Leu Asp 
            740                 745                 750         


Ile Asp His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys 
        755                 760                 765             


Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser 
    770                 775                 780                 


Arg Ile Ile Thr Arg Met Gln Ala Gln Ala Arg Gly Gln Leu Met Arg 
785                 790                 795                 800 


Ile Glu Phe Lys Lys Ile Val Glu Arg Arg Asp Ala Leu Leu Val Ile 
                805                 810                 815     


Gln Trp Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met 
            820                 825                 830         


Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu 
        835                 840                 845             


Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gly Arg Ile Lys Glu Thr 
    850                 855                 860                 


Leu Glu Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val 
865                 870                 875                 880 


Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu 
                885                 890                 895     


Gln Asp Asn Leu Asn Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys 
            900                 905                 910         


Asn Lys Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu 
        915                 920                 925             


Glu Asp Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys 
    930                 935                 940                 


Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu 
945                 950                 955                 960 


Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys 
                965                 970                 975     


Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala 
            980                 985                 990         


Lys Leu Thr Lys Glu Lys Lys Ala  Leu Gln Glu Ala His  Gln Gln Ala 
        995                 1000                 1005             


Leu Asp  Asp Leu Gln Val Glu  Glu Asp Lys Val Asn  Ser Leu Ser 
    1010                 1015                 1020             


Lys Ser  Lys Val Lys Leu Glu  Gln Gln Val Asp Asp  Leu Glu Gly 
    1025                 1030                 1035             


Ser Leu  Glu Gln Glu Lys Lys  Val Arg Met Asp Leu  Glu Arg Ala 
    1040                 1045                 1050             


Lys Arg  Lys Leu Glu Gly Asp  Leu Lys Leu Thr Gln  Glu Ser Ile 
    1055                 1060                 1065             


Met Asp  Leu Glu Asn Asp Lys  Leu Gln Leu Glu Glu  Lys Leu Lys 
    1070                 1075                 1080             


Lys Lys  Glu Phe Asp Ile Asn  Gln Gln Asn Ser Lys  Ile Glu Asp 
    1085                 1090                 1095             


Glu Gln  Val Leu Ala Leu Gln  Leu Gln Lys Lys Leu  Lys Glu Asn 
    1100                 1105                 1110             


Gln Ala  Arg Ile Glu Glu Leu  Glu Glu Glu Leu Glu  Ala Glu Arg 
    1115                 1120                 1125             


Thr Ala  Arg Ala Lys Val Glu  Lys Leu Arg Ser Asp  Leu Ser Arg 
    1130                 1135                 1140             


Glu Leu  Glu Glu Ile Ser Glu  Arg Leu Glu Glu Ala  Gly Gly Ala 
    1145                 1150                 1155             


Thr Ser  Val Gln Ile Glu Met  Asn Lys Lys Arg Glu  Ala Glu Phe 
    1160                 1165                 1170             


Gln Lys  Met Arg Arg Asp Leu  Glu Glu Ala Thr Leu  Gln His Glu 
    1175                 1180                 1185             


Ala Thr  Ala Ala Ala Leu Arg  Lys Lys His Ala Asp  Ser Val Ala 
    1190                 1195                 1200             


Glu Leu  Gly Glu Gln Ile Asp  Asn Leu Gln Arg Val  Lys Gln Lys 
    1205                 1210                 1215             


Leu Glu  Lys Glu Lys Ser Glu  Phe Lys Leu Glu Leu  Asp Asp Val 
    1220                 1225                 1230             


Thr Ser  Asn Met Glu Gln Ile  Ile Lys Ala Lys Ala  Asn Leu Glu 
    1235                 1240                 1245             


Lys Val  Ser Arg Thr Leu Glu  Asp Gln Ala Asn Glu  Tyr Arg Val 
    1250                 1255                 1260             


Lys Leu  Glu Glu Ala Gln Arg  Ser Leu Asn Asp Phe  Thr Thr Gln 
    1265                 1270                 1275             


Arg Ala  Lys Leu Gln Thr Glu  Asn Gly Glu Leu Ala  Arg Gln Leu 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ala Leu Ile  Ser Gln Leu Thr Arg  Gly Lys Leu 
    1295                 1300                 1305             


Ser Tyr  Thr Gln Gln Met Glu  Asp Leu Lys Arg Gln  Leu Glu Glu 
    1310                 1315                 1320             


Glu Gly  Lys Ala Lys Asn Ala  Leu Ala His Ala Leu  Gln Ser Ala 
    1325                 1330                 1335             


Arg His  Asp Cys Asp Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Thr 
    1340                 1345                 1350             


Glu Ala  Lys Ala Glu Leu Gln  Arg Val Leu Ser Lys  Ala Asn Ser 
    1355                 1360                 1365             


Glu Val  Ala Gln Trp Arg Thr  Lys Tyr Glu Thr Asp  Ala Ile Gln 
    1370                 1375                 1380             


Arg Thr  Glu Glu Leu Glu Glu  Ala Lys Lys Lys Leu  Ala Gln Arg 
    1385                 1390                 1395             


Leu Gln  Asp Ala Glu Glu Ala  Val Glu Ala Val Asn  Ala Lys Cys 
    1400                 1405                 1410             


Ser Ser  Leu Glu Lys Thr Lys  His Arg Leu Gln Asn  Glu Ile Glu 
    1415                 1420                 1425             


Asp Leu  Met Val Asp Val Glu  Arg Ser Asn Ala Ala  Ala Ala Ala 
    1430                 1435                 1440             


Leu Asp  Lys Lys Gln Arg Asn  Phe Asp Lys Ile Leu  Ala Glu Trp 
    1445                 1450                 1455             


Lys Gln  Lys Tyr Glu Glu Ser  Gln Ser Glu Leu Glu  Ser Ser Gln 
    1460                 1465                 1470             


Lys Glu  Ala Arg Ser Leu Ser  Thr Glu Leu Phe Lys  Leu Lys Asn 
    1475                 1480                 1485             


Ala Tyr  Glu Glu Ser Leu Glu  His Leu Glu Thr Phe  Lys Arg Glu 
    1490                 1495                 1500             


Asn Lys  Asn Leu Gln Glu Glu  Ile Ser Asp Leu Thr  Glu Gln Leu 
    1505                 1510                 1515             


Gly Glu  Gly Gly Lys Asn Val  His Glu Leu Glu Lys  Val Arg Lys 
    1520                 1525                 1530             


Gln Leu  Glu Val Glu Lys Leu  Glu Leu Gln Ser Ala  Leu Glu Glu 
    1535                 1540                 1545             


Ala Glu  Ala Ser Leu Glu His  Glu Glu Gly Lys Ile  Leu Arg Ala 
    1550                 1555                 1560             


Gln Leu  Glu Phe Asn Gln Ile  Lys Ala Glu Ile Glu  Arg Lys Leu 
    1565                 1570                 1575             


Ala Glu  Lys Asp Glu Glu Met  Glu Gln Ala Lys Arg  Asn His Gln 
    1580                 1585                 1590             


Arg Val  Val Asp Ser Leu Gln  Thr Ser Leu Asp Ala  Glu Thr Arg 
    1595                 1600                 1605             


Ser Arg  Asn Glu Val Leu Arg  Val Lys Lys Lys Met  Glu Gly Asp 
    1610                 1615                 1620             


Leu Asn  Glu Met Glu Ile Gln  Leu Ser His Ala Asn  Arg Met Ala 
    1625                 1630                 1635             


Ala Glu  Ala Gln Lys Gln Val  Lys Ser Leu Gln Ser  Leu Leu Lys 
    1640                 1645                 1650             


Asp Thr  Gln Ile Gln Leu Asp  Asp Ala Val Arg Ala  Asn Asp Asp 
    1655                 1660                 1665             


Leu Lys  Glu Asn Ile Ala Ile  Val Glu Arg Arg Asn  Asn Leu Leu 
    1670                 1675                 1680             


Gln Ala  Glu Leu Glu Glu Leu  Arg Ala Val Val Glu  Gln Thr Glu 
    1685                 1690                 1695             


Arg Ser  Arg Lys Leu Ala Glu  Gln Glu Leu Ile Glu  Thr Ser Glu 
    1700                 1705                 1710             


Arg Val  Gln Leu Leu His Ser  Gln Asn Thr Ser Leu  Ile Asn Gln 
    1715                 1720                 1725             


Lys Lys  Lys Met Glu Ser Asp  Leu Thr Gln Leu Gln  Ser Glu Val 
    1730                 1735                 1740             


Glu Glu  Ala Val Gln Glu Cys  Arg Asn Ala Glu Glu  Lys Ala Lys 
    1745                 1750                 1755             


Lys Ala  Ile Thr Asp Ala Ala  Met Met Ala Glu Glu  Leu Lys Lys 
    1760                 1765                 1770             


Glu Gln  Asp Thr Ser Ala His  Leu Glu Arg Met Lys  Lys Asn Met 
    1775                 1780                 1785             


Glu Gln  Thr Ile Lys Asp Leu  Gln His Arg Leu Asp  Glu Ala Glu 
    1790                 1795                 1800             


Gln Ile  Ala Leu Lys Gly Gly  Lys Lys Gln Leu Gln  Lys Leu Glu 
    1805                 1810                 1815             


Ala Arg  Val Arg Glu Leu Glu  Gly Glu Leu Glu Ala  Glu Gln Lys 
    1820                 1825                 1830             


Arg Asn  Ala Glu Ser Val Lys  Gly Met Arg Lys Ser  Glu Arg Arg 
    1835                 1840                 1845             


Ile Lys  Glu Leu Thr Tyr Gln  Thr Glu Glu Asp Lys  Lys Asn Leu 
    1850                 1855                 1860             


Leu Arg  Leu Gln Asp Leu Val  Asp Lys Leu Gln Leu  Lys Val Lys 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Gln Ala Glu  Glu Ala Glu Glu Gln  Ala Asn Thr 
    1880                 1885                 1890             


Asn Leu  Ser Lys Phe Arg Lys  Val Gln His Glu Leu  Asp Glu Ala 
    1895                 1900                 1905             


Glu Glu  Arg Ala Asp Ile Ala  Glu Ser Gln Val Asn  Lys Leu Arg 
    1910                 1915                 1920             


Ala Lys  Ser Arg Asp Ile Gly  Ala Lys Gln Lys Met  His Asp Glu 
    1925                 1930                 1935             


Glu 
    


