                         SEQUENCE LISTING

<110>  OSE IMMUNOTHERAPEUTICS
 
<120>  Non-antagonistic antibodies directed against the alpha chain of 
       IL7 receptor extracellular domain and use thereof in cancer 
       treatment.

<130>  B11725A/AD/FS

<150>  62/301271
<151>  2016-02-29

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3

<400>  1
gctgtgcagc tggtcgaatc tggggggggg ctggtccagc ccggcgggtc tctgaaaatc       60

acttgcgccg ctagtgggtt cacctttaca aacgcagcca tgtactgggt ccgacaggct      120

cctggaaagg gcctggagtg ggtggcacgg atcagaacaa aggctaacaa ctacgcaact      180

tactatgccg actcagtgaa gggcaggttc accattagcc gcgacgatag caaatccaca      240

gtctacctgc agatggactc tgtgaagaca gaagatactg ccacctacta ttgtattgtg      300

gtcgtgctga ctactacacg ggattacttt gactattggg gacagggagt gctggtgaca      360

gtgagttca                                                              369


<210>  2
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_aa

<400>  2

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Ile Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Ser Val Lys Thr Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3

<400>  3
gacatcgtcc tgactcagtc cccctcttcc ctgccagtga cacctggaga gccagcatct       60

atcagttgcc gaagctccca gtcactgctg actgtcaagg gaattaccag cctgtactgg      120

ttcctgcaga agcccggcca gtcccctaaa ctgctgatct atcggatgtc taacagagac      180

agtggggtgc ccgataggtt ctcaggcagc gggtccgaaa ccgactttac actgaaaatt      240

tctcgcgtgg aggctgaaga tgtcggaacc tactattgcg cacagtttct ggaataccct      300

cacactttcg gggcaggcac taagctggag ctgaagcgt                             339


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3_aa

<400>  4

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Thr Val 
            20                  25                  30          


Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr Cys Ala Gln Phe 
                85                  90                  95      


Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  5
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4

<400>  5
gacatcgtgc tgacacagag tccctcctcc ctgccagtga cacctggaga gccagcatct       60

atcagttgcc gaagctccca ggacctgctg actgtcaagg gcattacctc actgtactgg      120

ttcctgcaga agcccgggca gagccctaaa ctgctgatct atcggatgtc taacagagac      180

agtggagtgc ccgataggtt ctcaggcagc gggtccggaa ccgactttac actgaaaatt      240

tctcgcgtgg aggctgaaga tgtcggcacc tactattgcg cacagtttct ggagtatccc      300

cacacctttg gagcaggcac taagctggag ctgaagcgt                             339


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4_aa

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asp Leu Leu Thr Val 
            20                  25                  30          


Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr Cys Ala Gln Phe 
                85                  90                  95      


Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  7
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3 (+signal peptide)

<400>  7
atgctggtcc tgcagtgggt cctggtcacc gctctgtttc agggggtcca ttgtgctgtg       60

cagctggtcg aatctggggg ggggctggtc cagcccggcg ggtctctgaa aatcacttgc      120

gccgctagtg ggttcacctt tacaaacgca gccatgtact gggtccgaca ggctcctgga      180

aagggcctgg agtgggtggc acggatcaga acaaaggcta acaactacgc aacttactat      240

gccgactcag tgaagggcag gttcaccatt agccgcgacg atagcaaatc cacagtctac      300

ctgcagatgg actctgtgaa gacagaagat actgccacct actattgtat tgtggtcgtg      360

ctgactacta cacgggatta ctttgactat tggggacagg gagtgctggt gacagtgagt      420

tca                                                                    423


<210>  8
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_aa (+signal peptide)

<400>  8

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Ile Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr 
        35                  40                  45              


Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asp Ser Val Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
    130                 135                 140     


<210>  9
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3 (+signal peptide)

<400>  9
atgaagtttc ctgctcagtt tctgggcctg attgtgctgt gtattcctgg cgctaccgga       60

gacatcgtcc tgactcagtc cccctcttcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca gtcactgctg actgtcaagg gaattaccag cctgtactgg      180

ttcctgcaga agcccggcca gtcccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggggtgc ccgataggtt ctcaggcagc gggtccgaaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggaacc tactattgcg cacagtttct ggaataccct      360

cacactttcg gggcaggcac taagctggag ctgaagcgt                             399


<210>  10
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3_aa (+signal peptide)

<400>  10

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  11
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4 (+signal peptide)

<400>  11
atgaagttcc ctgctcagtt cctggggctg attgtcctgt gcattcctgg ggcaaccggc       60

gacatcgtgc tgacacagag tccctcctcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca ggacctgctg actgtcaagg gcattacctc actgtactgg      180

ttcctgcaga agcccgggca gagccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggagtgc ccgataggtt ctcaggcagc gggtccggaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggcacc tactattgcg cacagtttct ggagtatccc      360

cacacctttg gagcaggcac taagctggag ctgaagcgt                             399


<210>  12
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4_aa (+signal peptide)

<400>  12

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asp 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR1

<400>  13
ttcaccttta caaacgcagc catgtac                                           27


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR1-aa

<400>  14

Phe Thr Phe Thr Asn Ala Ala Met Tyr 
1               5                   


<210>  15
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR2

<400>  15
cggatcagaa caaaggctaa caactacgca acttactatg ccgactcagt gaagggc          57


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR2-aa

<400>  16

Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  17
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR3

<400>  17
gtcgtgctga ctactacacg ggattacttt gactat                                 36


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VHvar3_CDR3-aa

<400>  18

Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  19
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3_CDR1

<400>  19
cgaagctccc agtcactgct gactgtcaag ggaattacca gcctgtac                    48


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3-CDR1_aa

<400>  20

Arg Ser Ser Gln Ser Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3/4_CDR2

<400>  21
cggatgtcta acagagacag t                                                 21


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3/4_CDR2aa

<400>  22

Arg Met Ser Asn Arg Asp Ser 
1               5           


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3/4_CDR3

<400>  23
gcacagtttc tggaataccc tcacact                                           27


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3 VLvar3/4_CDR3aa

<400>  24

Ala Gln Phe Leu Glu Tyr Pro His Thr 
1               5                   


<210>  25
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4_CDR1

<400>  25
cgaagctccc aggacctgct gactgtcaag ggcattacct cactgtac                    48


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3-VLvar4_CDR1_aa

<400>  26

Arg Ser Ser Gln Asp Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  27
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1m (E333A)

<400>  27
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgcgaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  28
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1m (E333A)_aa

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  29
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4m (S228P)

<400>  29
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctccgggtaa atga                                             984


<210>  30
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4m (S228P)_aa

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  31
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG2b

<400>  31
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaatg a                                                981


<210>  32
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2b_aa

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  33
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLkappa

<400>  33
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  34
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLkappa_aa

<400>  34

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  35
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLlambda

<400>  35
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcata g                                                321


<210>  36
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLlambda_aa

<400>  36

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  37
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanFc_IgG1(UniprotP01857)

<400>  37

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  38
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanFc_IgG4(UniprotP01861)

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  39
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD127 aa

<400>  39

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  40
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD127_21-239 aa

<400>  40

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
    210                 215                 


<210>  41
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG1m(E333A)

<400>  41
atgctggtcc tgcagtgggt cctggtcacc gctctgtttc agggggtcca ttgtgctgtg       60

cagctggtcg aatctggggg ggggctggtc cagcccggcg ggtctctgaa aatcacttgc      120

gccgctagtg ggttcacctt tacaaacgca gccatgtact gggtccgaca ggctcctgga      180

aagggcctgg agtgggtggc acggatcaga acaaaggcta acaactacgc aacttactat      240

gccgactcag tgaagggcag gttcaccatt agccgcgacg atagcaaatc cacagtctac      300

ctgcagatgg actctgtgaa gacagaagat actgccacct actattgtat tgtggtcgtg      360

ctgactacta cacgggatta ctttgactat tggggacagg gagtgctggt gacagtgagt      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcgc gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  42
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG1m(E333A)_aa

<400>  42

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Ile Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr 
        35                  40                  45              


Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asp Ser Val Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  43
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG4(S228P)

<400>  43
atgctggtcc tgcagtgggt cctggtcacc gctctgtttc agggggtcca ttgtgctgtg       60

cagctggtcg aatctggggg ggggctggtc cagcccggcg ggtctctgaa aatcacttgc      120

gccgctagtg ggttcacctt tacaaacgca gccatgtact gggtccgaca ggctcctgga      180

aagggcctgg agtgggtggc acggatcaga acaaaggcta acaactacgc aacttactat      240

gccgactcag tgaagggcag gttcaccatt agccgcgacg atagcaaatc cacagtctac      300

ctgcagatgg actctgtgaa gacagaagat actgccacct actattgtat tgtggtcgtg      360

ctgactacta cacgggatta ctttgactat tggggacagg gagtgctggt gacagtgagt      420

tcagctagca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  44
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG4(S228P)_aa

<400>  44

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Ile Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr 
        35                  40                  45              


Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asp Ser Val Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  45
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG2b

<400>  45
atgctggtcc tgcagtgggt cctggtcacc gctctgtttc agggggtcca ttgtgctgtg       60

cagctggtcg aatctggggg ggggctggtc cagcccggcg ggtctctgaa aatcacttgc      120

gccgctagtg ggttcacctt tacaaacgca gccatgtact gggtccgaca ggctcctgga      180

aagggcctgg agtgggtggc acggatcaga acaaaggcta acaactacgc aacttactat      240

gccgactcag tgaagggcag gttcaccatt agccgcgacg atagcaaatc cacagtctac      300

ctgcagatgg actctgtgaa gacagaagat actgccacct actattgtat tgtggtcgtg      360

ctgactacta cacgggatta ctttgactat tggggacagg gagtgctggt gacagtgagt      420

tcagctagca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccat gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atga                                            1404


<210>  46
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VH3_IgG2b_aa

<400>  46

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Ile Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr 
        35                  40                  45              


Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asp Ser Val Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  47
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VL4_CLkappa

<400>  47
atgaagttcc ctgctcagtt cctggggctg attgtcctgt gcattcctgg ggcaaccggc       60

gacatcgtgc tgacacagag tccctcctcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca ggacctgctg actgtcaagg gcattacctc actgtactgg      180

ttcctgcaga agcccgggca gagccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggagtgc ccgataggtt ctcaggcagc gggtccggaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggcacc tactattgcg cacagtttct ggagtatccc      360

cacacctttg gagcaggcac taagctggag ctgaagcgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      720


<210>  48
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VL4_CLkappa_aa

<400>  48

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asp 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  49
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VL3_Clkappa

<400>  49
atgaagtttc ctgctcagtt tctgggcctg attgtgctgt gtattcctgg cgctaccgga       60

gacatcgtcc tgactcagtc cccctcttcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca gtcactgctg actgtcaagg gaattaccag cctgtactgg      180

ttcctgcaga agcccggcca gtcccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggggtgc ccgataggtt ctcaggcagc gggtccgaaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggaacc tactattgcg cacagtttct ggaataccct      360

cacactttcg gggcaggcac taagctggag ctgaagcgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      720


<210>  50
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VL3_CLkappa_aa

<400>  50

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  51
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VL4_Cllambda

<400>  51
atgaagttcc ctgctcagtt cctggggctg attgtcctgt gcattcctgg ggcaaccggc       60

gacatcgtgc tgacacagag tccctcctcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca ggacctgctg actgtcaagg gcattacctc actgtactgg      180

ttcctgcaga agcccgggca gagccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggagtgc ccgataggtt ctcaggcagc gggtccggaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggcacc tactattgcg cacagtttct ggagtatccc      360

cacacctttg gagcaggcac taagctggag ctgaagcgtg gtcagcccaa ggctgccccc      420

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc      540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      600

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcatag      720


<210>  52
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VL4_CLlambda_aa

<400>  52

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asp 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 


<210>  53
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effi3_VL3_Cllambda

<400>  53
atgaagtttc ctgctcagtt tctgggcctg attgtgctgt gtattcctgg cgctaccgga       60

gacatcgtcc tgactcagtc cccctcttcc ctgccagtga cacctggaga gccagcatct      120

atcagttgcc gaagctccca gtcactgctg actgtcaagg gaattaccag cctgtactgg      180

ttcctgcaga agcccggcca gtcccctaaa ctgctgatct atcggatgtc taacagagac      240

agtggggtgc ccgataggtt ctcaggcagc gggtccgaaa ccgactttac actgaaaatt      300

tctcgcgtgg aggctgaaga tgtcggaacc tactattgcg cacagtttct ggaataccct      360

cacactttcg gggcaggcac taagctggag ctgaagcgtg gtcagcccaa ggctgccccc      420

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc      540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      600

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcatag      720


<210>  54
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effi3_VL3_CLlambda_aa

<400>  54

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Met Ser Asn Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 


<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD127 peptide

<400>  55

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu 
            20                  25          


<210>  56
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MD707-3 VH

<400>  56

Ala Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Val Lys Thr Asp Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120             


<210>  57
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MD707-3 VL

<400>  57

Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Thr Val 
            20                  25                  30          


Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Arg Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Phe 
                85                  90                  95      


Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT1

<400>  58

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT2

<400>  59

Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT3

<400>  60

Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT4

<400>  61

Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT5

<400>  62

Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT6

<400>  63

Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT7

<400>  64

Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT8

<400>  65

Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT9

<400>  66

His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT10

<400>  67

Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn Leu Glu Phe 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT11

<400>  68

Asp Pro Asp Val Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT12

<400>  69

Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT13

<400>  70

Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT14

<400>  71

Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT15

<400>  72

Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT16

<400>  73

Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT17

<400>  74

Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT18

<400>  75

Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT19

<400>  76

Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT20

<400>  77

Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT21

<400>  78

Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT22

<400>  79

Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT23

<400>  80

Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT24

<400>  81

Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT25

<400>  82

Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT26

<400>  83

Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT27

<400>  84

Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT28

<400>  85

Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT29

<400>  86

Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT30

<400>  87

Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT31

<400>  88

Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT32

<400>  89

Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT33

<400>  90

Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT34

<400>  91

Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT35

<400>  92

Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT36

<400>  93

Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT37

<400>  94

His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT38

<400>  95

Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT39

<400>  96

Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT40

<400>  97

Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT41

<400>  98

Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT42

<400>  99

Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT43

<400>  100

Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT44

<400>  101

Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT45

<400>  102

Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT46

<400>  103

Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT47

<400>  104

Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT48

<400>  105

Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT49

<400>  106

Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT50

<400>  107

Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT51

<400>  108

Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPT52

<400>  109

Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
1               5                   10                  15  


