                         SEQUENCE LISTING

<110>  OXFORD NANOPORE TECHNOLOGIES LIMITED
 
<120>  MUTANT PORE

<130>  N407666WO

<140>  TBC
<141>  TBC

<150>  GB1603656.8
<151>  2016-03-02

<150>  GB1603657.6
<151>  2016-03-02

<150>  GB1603658.4
<151>  2016-03-02

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  786
<212>  DNA
<213>  Escherichia coli

<400>  1
tgtctgaccg caccgccgaa agaagcggca cgtccgaccc tgatgccgcg tgcacagtct       60

tataaagatc tgacccatct gccggctccg acgggcaaaa tttttgttag cgtctataac      120

atccaggacg aaaccggtca atttaaaccg tacccggcga gtaatttctc cacggccgtt      180

ccgcagagtg caaccgctat gctggtcacg gcactgaaag attcccgttg gttcattccg      240

ctggaacgcc agggcctgca aaacctgctg aatgaacgta aaattatccg cgcagctcag      300

gaaaacggta ccgtggccat taacaatcgt attccgctgc aaagcctgac cgccgcaaac      360

atcatggttg aaggctctat catcggttac gaatcaaacg tcaaatcggg cggtgtgggc      420

gcacgttatt ttggcattgg tgctgatacc cagtaccaac tggaccagat cgcagttaac      480

ctgcgcgtgg ttaatgtcag caccggcgaa attctgagct ctgtgaatac cagcaaaacg      540

atcctgtctt acgaagtgca ggctggtgtt tttcgtttca ttgattatca acgcctgctg      600

gaaggcgaag tcggttacac ctcaaacgaa ccggtgatgc tgtgtctgat gtcggcgatt      660

gaaacgggtg ttattttcct gatcaatgat ggcatcgacc gtggtctgtg ggatctgcag      720

aacaaagccg aacgtcaaaa tgacattctg gtgaaatacc gccacatgag tgttccgccg      780

gaatcc                                                                 786


<210>  2
<211>  262
<212>  PRT
<213>  Escherichia coli

<400>  2

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Arg Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Ala Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Ile Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Gln Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Val Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Asn Lys Ala Glu Arg Gln Asn Asp Ile Leu Val Lys Tyr Arg His Met 
                245                 250                 255     


Ser Val Pro Pro Glu Ser 
            260         


<210>  3
<211>  248
<212>  PRT
<213>  Citrobacter koseri

<400>  3

Met Pro Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Met Pro 
1               5                   10                  15      


Thr Gly Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly 
            20                  25                  30          


Gln Phe Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln 
        35                  40                  45              


Ser Ala Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe 
    50                  55                  60                  


Ile Pro Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys 
65                  70                  75                  80  


Ile Ile Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Ile Asn Asn Arg 
                85                  90                  95      


Ile Pro Leu Gln Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser 
            100                 105                 110         


Ile Ile Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg 
        115                 120                 125             


Tyr Phe Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala 
    130                 135                 140                 


Val Asn Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser 
145                 150                 155                 160 


Val Asn Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val 
                165                 170                 175     


Phe Arg Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr 
            180                 185                 190         


Thr Ser Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr 
        195                 200                 205             


Gly Val Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp 
    210                 215                 220                 


Leu Gln Asn Lys Ala Glu Arg Gln Asn Asp Ile Leu Val Lys Tyr Arg 
225                 230                 235                 240 


His Met Ser Val Pro Pro Glu Ser 
                245             


<210>  4
<211>  223
<212>  PRT
<213>  Salmonella enterica

<400>  4

Cys Leu Thr Ala Pro Pro Lys Gln Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Ala Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Met Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Gln Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly 
    210                 215                 220             


<210>  5
<211>  262
<212>  PRT
<213>  Citrobacter amalonaticus

<400>  5

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Ile Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Val Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Ile Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Gln Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Asn Lys Ala Asp Arg Gln Asn Asp Ile Leu Val Lys Tyr Arg His Met 
                245                 250                 255     


Ser Val Pro Pro Glu Ser 
            260         


<210>  6
<211>  262
<212>  PRT
<213>  Citrobacter rodentium

<400>  6

Cys Leu Thr Thr Pro Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Val Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Ile Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Pro Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Ala Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Asn Lys Ala Asp Arg Gln Asn Asp Ile Leu Val Lys Tyr Arg Gln Met 
                245                 250                 255     


Ser Val Pro Pro Glu Ser 
            260         


<210>  7
<211>  262
<212>  PRT
<213>  Enterobacter asburiae

<400>  7

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Arg Asp Leu Thr His Leu Pro Ala Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser His Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Asn Asn Asn Arg Met Pro 
            100                 105                 110         


Leu Gln Ser Leu Ala Ala Ala Asn Val Met Ile Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Met Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Asn Lys Ala Asp Ala Gln Asn Pro Val Leu Val Lys Tyr Arg Asp Met 
                245                 250                 255     


Ser Val Pro Pro Glu Ser 
            260         


<210>  8
<211>  1830
<212>  DNA
<213>  Bacteriophage phi-29

<400>  8
atgaaacaca tgccgcgtaa aatgtatagc tgcgcgtttg aaaccacgac caaagtggaa       60

gattgtcgcg tttgggccta tggctacatg aacatcgaag atcattctga atacaaaatc      120

ggtaacagtc tggatgaatt tatggcatgg gtgctgaaag ttcaggcgga tctgtacttc      180

cacaacctga aatttgatgg cgcattcatt atcaactggc tggaacgtaa tggctttaaa      240

tggagcgcgg atggtctgcc gaacacgtat aataccatta tctctcgtat gggccagtgg      300

tatatgattg atatctgcct gggctacaaa ggtaaacgca aaattcatac cgtgatctat      360

gatagcctga aaaaactgcc gtttccggtg aagaaaattg cgaaagattt caaactgacg      420

gttctgaaag gcgatattga ttatcacaaa gaacgtccgg ttggttacaa aatcaccccg      480

gaagaatacg catacatcaa aaacgatatc cagatcatcg cagaagcgct gctgattcag      540

tttaaacagg gcctggatcg catgaccgcg ggcagtgata gcctgaaagg tttcaaagat      600

atcatcacga ccaaaaaatt caaaaaagtg ttcccgacgc tgagcctggg tctggataaa      660

gaagttcgtt atgcctaccg cggcggtttt acctggctga acgatcgttt caaagaaaaa      720

gaaattggcg agggtatggt gtttgatgtt aatagtctgt atccggcaca gatgtacagc      780

cgcctgctgc cgtatggcga accgatcgtg ttcgagggta aatatgtttg ggatgaagat      840

tacccgctgc atattcagca catccgttgt gaatttgaac tgaaagaagg ctatattccg      900

accattcaga tcaaacgtag tcgcttctat aagggtaacg aatacctgaa aagctctggc      960

ggtgaaatcg cggatctgtg gctgagtaac gtggatctgg aactgatgaa agaacactac     1020

gatctgtaca acgttgaata catcagcggc ctgaaattta aagccacgac cggtctgttc     1080

aaagatttca tcgataaatg gacctacatc aaaacgacct ctgaaggcgc gattaaacag     1140

ctggccaaac tgatgctgaa cagcctgtat ggcaaattcg cctctaatcc ggatgtgacc     1200

ggtaaagttc cgtacctgaa agaaaatggc gcactgggtt ttcgcctggg cgaagaagaa     1260

acgaaagatc cggtgtatac cccgatgggt gttttcatta cggcctgggc acgttacacg     1320

accatcaccg cggcccaggc atgctatgat cgcattatct actgtgatac cgattctatt     1380

catctgacgg gcaccgaaat cccggatgtg attaaagata tcgttgatcc gaaaaaactg     1440

ggttattggg cccacgaaag tacgtttaaa cgtgcaaaat acctgcgcca gaaaacctac     1500

atccaggata tctacatgaa agaagtggat ggcaaactgg ttgaaggttc tccggatgat     1560

tacaccgata tcaaattcag tgtgaaatgc gccggcatga cggataaaat caaaaaagaa     1620

gtgaccttcg aaaacttcaa agttggtttc agccgcaaaa tgaaaccgaa accggtgcag     1680

gttccgggcg gtgtggttct ggtggatgat acgtttacca ttaaatctgg cggtagtgcg     1740

tggagccatc cgcagttcga aaaaggcggt ggctctggtg gcggttctgg cggtagtgcc     1800

tggagccacc cgcagtttga aaaataataa                                      1830


<210>  9
<211>  608
<212>  PRT
<213>  Bacteriophage phi-29

<400>  9

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Ala Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys Ser 
                565                 570                 575     


Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        595                 600                 605             


<210>  10
<211>  1390
<212>  DNA
<213>  Escherichia coli

<400>  10
atgatgaacg atggcaaaca gcagagcacc ttcctgtttc atgattatga aaccttcggt       60

acccatccgg ccctggatcg tccggcgcag tttgcggcca ttcgcaccga tagcgaattc      120

aatgtgattg gcgaaccgga agtgttttat tgcaaaccgg ccgatgatta tctgccgcag      180

ccgggtgcgg tgctgattac cggtattacc ccgcaggaag cgcgcgcgaa aggtgaaaac      240

gaagcggcgt ttgccgcgcg cattcatagc ctgtttaccg tgccgaaaac ctgcattctg      300

ggctataaca atgtgcgctt cgatgatgaa gttacccgta atatctttta tcgtaacttt      360

tatgatccgt atgcgtggag ctggcagcat gataacagcc gttgggatct gctggatgtg      420

atgcgcgcgt gctatgcgct gcgcccggaa ggcattaatt ggccggaaaa cgatgatggc      480

ctgccgagct ttcgtctgga acatctgacc aaagccaacg gcattgaaca tagcaatgcc      540

catgatgcga tggccgatgt ttatgcgacc attgcgatgg cgaaactggt taaaacccgt      600

cagccgcgcc tgtttgatta tctgtttacc caccgtaaca aacacaaact gatggcgctg      660

attgatgttc cgcagatgaa accgctggtg catgtgagcg gcatgtttgg cgcctggcgc      720

ggcaacacca gctgggtggc cccgctggcc tggcacccgg aaaatcgtaa cgccgtgatt      780

atggttgatc tggccggtga tattagcccg ctgctggaac tggatagcga taccctgcgt      840

gaacgcctgt ataccgccaa aaccgatctg ggcgataatg ccgccgtgcc ggtgaaactg      900

gttcacatta acaaatgccc ggtgctggcc caggcgaaca ccctgcgccc ggaagatgcg      960

gatcgtctgg gtattaatcg ccagcattgt ctggataatc tgaaaatcct gcgtgaaaac     1020

ccgcaggtgc gtgaaaaagt ggtggcgatc ttcgcggaag cggaaccgtt caccccgagc     1080

gataacgtgg atgcgcagct gtataacggc ttctttagcg atgccgatcg cgcggcgatg     1140

aaaatcgttc tggaaaccga accgcgcaat ctgccggcgc tggatattac ctttgttgat     1200

aaacgtattg aaaaactgct gtttaattat cgtgcgcgca attttccggg taccctggat     1260

tatgccgaac agcagcgttg gctggaacat cgtcgtcagg ttttcacccc ggaatttctg     1320

cagggttatg cggatgaact gcagatgctg gttcagcagt atgccgatga taaagaaaaa     1380

gtggcgctgc                                                            1390


<210>  11
<211>  485
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Met Asn Asp Gly Lys Gln Gln Ser Thr Phe Leu Phe His Asp Tyr 
1               5                   10                  15      


Glu Thr Phe Gly Thr His Pro Ala Leu Asp Arg Pro Ala Gln Phe Ala 
            20                  25                  30          


Ala Ile Arg Thr Asp Ser Glu Phe Asn Val Ile Gly Glu Pro Glu Val 
        35                  40                  45              


Phe Tyr Cys Lys Pro Ala Asp Asp Tyr Leu Pro Gln Pro Gly Ala Val 
    50                  55                  60                  


Leu Ile Thr Gly Ile Thr Pro Gln Glu Ala Arg Ala Lys Gly Glu Asn 
65                  70                  75                  80  


Glu Ala Ala Phe Ala Ala Arg Ile His Ser Leu Phe Thr Val Pro Lys 
                85                  90                  95      


Thr Cys Ile Leu Gly Tyr Asn Asn Val Arg Phe Asp Asp Glu Val Thr 
            100                 105                 110         


Arg Asn Ile Phe Tyr Arg Asn Phe Tyr Asp Pro Tyr Ala Trp Ser Trp 
        115                 120                 125             


Gln His Asp Asn Ser Arg Trp Asp Leu Leu Asp Val Met Arg Ala Cys 
    130                 135                 140                 


Tyr Ala Leu Arg Pro Glu Gly Ile Asn Trp Pro Glu Asn Asp Asp Gly 
145                 150                 155                 160 


Leu Pro Ser Phe Arg Leu Glu His Leu Thr Lys Ala Asn Gly Ile Glu 
                165                 170                 175     


His Ser Asn Ala His Asp Ala Met Ala Asp Val Tyr Ala Thr Ile Ala 
            180                 185                 190         


Met Ala Lys Leu Val Lys Thr Arg Gln Pro Arg Leu Phe Asp Tyr Leu 
        195                 200                 205             


Phe Thr His Arg Asn Lys His Lys Leu Met Ala Leu Ile Asp Val Pro 
    210                 215                 220                 


Gln Met Lys Pro Leu Val His Val Ser Gly Met Phe Gly Ala Trp Arg 
225                 230                 235                 240 


Gly Asn Thr Ser Trp Val Ala Pro Leu Ala Trp His Pro Glu Asn Arg 
                245                 250                 255     


Asn Ala Val Ile Met Val Asp Leu Ala Gly Asp Ile Ser Pro Leu Leu 
            260                 265                 270         


Glu Leu Asp Ser Asp Thr Leu Arg Glu Arg Leu Tyr Thr Ala Lys Thr 
        275                 280                 285             


Asp Leu Gly Asp Asn Ala Ala Val Pro Val Lys Leu Val His Ile Asn 
    290                 295                 300                 


Lys Cys Pro Val Leu Ala Gln Ala Asn Thr Leu Arg Pro Glu Asp Ala 
305                 310                 315                 320 


Asp Arg Leu Gly Ile Asn Arg Gln His Cys Leu Asp Asn Leu Lys Ile 
                325                 330                 335     


Leu Arg Glu Asn Pro Gln Val Arg Glu Lys Val Val Ala Ile Phe Ala 
            340                 345                 350         


Glu Ala Glu Pro Phe Thr Pro Ser Asp Asn Val Asp Ala Gln Leu Tyr 
        355                 360                 365             


Asn Gly Phe Phe Ser Asp Ala Asp Arg Ala Ala Met Lys Ile Val Leu 
    370                 375                 380                 


Glu Thr Glu Pro Arg Asn Leu Pro Ala Leu Asp Ile Thr Phe Val Asp 
385                 390                 395                 400 


Lys Arg Ile Glu Lys Leu Leu Phe Asn Tyr Arg Ala Arg Asn Phe Pro 
                405                 410                 415     


Gly Thr Leu Asp Tyr Ala Glu Gln Gln Arg Trp Leu Glu His Arg Arg 
            420                 425                 430         


Gln Val Phe Thr Pro Glu Phe Leu Gln Gly Tyr Ala Asp Glu Leu Gln 
        435                 440                 445             


Met Leu Val Gln Gln Tyr Ala Asp Asp Lys Glu Lys Val Ala Leu Leu 
    450                 455                 460                 


Lys Ala Leu Trp Gln Tyr Ala Glu Glu Ile Val Ser Gly Ser Gly His 
465                 470                 475                 480 


His His His His His 
                485 


<210>  12
<211>  804
<212>  DNA
<213>  Escherichia coli

<400>  12
atgaaatttg tctcttttaa tatcaacggc ctgcgcgcca gacctcacca gcttgaagcc       60

atcgtcgaaa agcaccaacc ggatgtgatt ggcctgcagg agacaaaagt tcatgacgat      120

atgtttccgc tcgaagaggt ggcgaagctc ggctacaacg tgttttatca cgggcagaaa      180

ggccattatg gcgtggcgct gctgaccaaa gagacgccga ttgccgtgcg tcgcggcttt      240

cccggtgacg acgaagaggc gcagcggcgg attattatgg cggaaatccc ctcactgctg      300

ggtaatgtca ccgtgatcaa cggttacttc ccgcagggtg aaagccgcga ccatccgata      360

aaattcccgg caaaagcgca gttttatcag aatctgcaaa actacctgga aaccgaactc      420

aaacgtgata atccggtact gattatgggc gatatgaata tcagccctac agatctggat      480

atcggcattg gcgaagaaaa ccgtaagcgc tggctgcgta ccggtaaatg ctctttcctg      540

ccggaagagc gcgaatggat ggacaggctg atgagctggg ggttggtcga taccttccgc      600

catgcgaatc cgcaaacagc agatcgtttc tcatggtttg attaccgctc aaaaggtttt      660

gacgataacc gtggtctgcg catcgacctg ctgctcgcca gccaaccgct ggcagaatgt      720

tgcgtagaaa ccggcatcga ctatgaaatc cgcagcatgg aaaaaccgtc cgatcacgcc      780

cccgtctggg cgaccttccg ccgc                                             804


<210>  13
<211>  268
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Lys Phe Val Ser Phe Asn Ile Asn Gly Leu Arg Ala Arg Pro His 
1               5                   10                  15      


Gln Leu Glu Ala Ile Val Glu Lys His Gln Pro Asp Val Ile Gly Leu 
            20                  25                  30          


Gln Glu Thr Lys Val His Asp Asp Met Phe Pro Leu Glu Glu Val Ala 
        35                  40                  45              


Lys Leu Gly Tyr Asn Val Phe Tyr His Gly Gln Lys Gly His Tyr Gly 
    50                  55                  60                  


Val Ala Leu Leu Thr Lys Glu Thr Pro Ile Ala Val Arg Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Asp Asp Glu Glu Ala Gln Arg Arg Ile Ile Met Ala Glu Ile 
                85                  90                  95      


Pro Ser Leu Leu Gly Asn Val Thr Val Ile Asn Gly Tyr Phe Pro Gln 
            100                 105                 110         


Gly Glu Ser Arg Asp His Pro Ile Lys Phe Pro Ala Lys Ala Gln Phe 
        115                 120                 125             


Tyr Gln Asn Leu Gln Asn Tyr Leu Glu Thr Glu Leu Lys Arg Asp Asn 
    130                 135                 140                 


Pro Val Leu Ile Met Gly Asp Met Asn Ile Ser Pro Thr Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ile Gly Glu Glu Asn Arg Lys Arg Trp Leu Arg Thr Gly Lys 
                165                 170                 175     


Cys Ser Phe Leu Pro Glu Glu Arg Glu Trp Met Asp Arg Leu Met Ser 
            180                 185                 190         


Trp Gly Leu Val Asp Thr Phe Arg His Ala Asn Pro Gln Thr Ala Asp 
        195                 200                 205             


Arg Phe Ser Trp Phe Asp Tyr Arg Ser Lys Gly Phe Asp Asp Asn Arg 
    210                 215                 220                 


Gly Leu Arg Ile Asp Leu Leu Leu Ala Ser Gln Pro Leu Ala Glu Cys 
225                 230                 235                 240 


Cys Val Glu Thr Gly Ile Asp Tyr Glu Ile Arg Ser Met Glu Lys Pro 
                245                 250                 255     


Ser Asp His Ala Pro Val Trp Ala Thr Phe Arg Arg 
            260                 265             


<210>  14
<211>  1275
<212>  DNA
<213>  Thermus thermophilus

<400>  14
atgtttcgtc gtaaagaaga tctggatccg ccgctggcac tgctgccgct gaaaggcctg       60

cgcgaagccg ccgcactgct ggaagaagcg ctgcgtcaag gtaaacgcat tcgtgttcac      120

ggcgactatg atgcggatgg cctgaccggc accgcgatcc tggttcgtgg tctggccgcc      180

ctgggtgcgg atgttcatcc gtttatcccg caccgcctgg aagaaggcta tggtgtcctg      240

atggaacgcg tcccggaaca tctggaagcc tcggacctgt ttctgaccgt tgactgcggc      300

attaccaacc atgcggaact gcgcgaactg ctggaaaatg gcgtggaagt cattgttacc      360

gatcatcata cgccgggcaa aacgccgccg ccgggtctgg tcgtgcatcc ggcgctgacg      420

ccggatctga aagaaaaacc gaccggcgca ggcgtggcgt ttctgctgct gtgggcactg      480

catgaacgcc tgggcctgcc gccgccgctg gaatacgcgg acctggcagc cgttggcacc      540

attgccgacg ttgccccgct gtggggttgg aatcgtgcac tggtgaaaga aggtctggca      600

cgcatcccgg cttcatcttg ggtgggcctg cgtctgctgg ctgaagccgt gggctatacc      660

ggcaaagcgg tcgaagtcgc tttccgcatc gcgccgcgca tcaatgcggc ttcccgcctg      720

ggcgaagcgg aaaaagccct gcgcctgctg ctgacggatg atgcggcaga agctcaggcg      780

ctggtcggcg aactgcaccg tctgaacgcc cgtcgtcaga ccctggaaga agcgatgctg      840

cgcaaactgc tgccgcaggc cgacccggaa gcgaaagcca tcgttctgct ggacccggaa      900

ggccatccgg gtgttatggg tattgtggcc tctcgcatcc tggaagcgac cctgcgcccg      960

gtctttctgg tggcccaggg caaaggcacc gtgcgttcgc tggctccgat ttccgccgtc     1020

gaagcactgc gcagcgcgga agatctgctg ctgcgttatg gtggtcataa agaagcggcg     1080

ggtttcgcaa tggatgaagc gctgtttccg gcgttcaaag cacgcgttga agcgtatgcc     1140

gcacgtttcc cggatccggt tcgtgaagtg gcactgctgg atctgctgcc ggaaccgggc     1200

ctgctgccgc aggtgttccg tgaactggca ctgctggaac cgtatggtga aggtaacccg     1260

gaaccgctgt tcctg                                                      1275


<210>  15
<211>  425
<212>  PRT
<213>  Thermus thermophilus

<400>  15

Met Phe Arg Arg Lys Glu Asp Leu Asp Pro Pro Leu Ala Leu Leu Pro 
1               5                   10                  15      


Leu Lys Gly Leu Arg Glu Ala Ala Ala Leu Leu Glu Glu Ala Leu Arg 
            20                  25                  30          


Gln Gly Lys Arg Ile Arg Val His Gly Asp Tyr Asp Ala Asp Gly Leu 
        35                  40                  45              


Thr Gly Thr Ala Ile Leu Val Arg Gly Leu Ala Ala Leu Gly Ala Asp 
    50                  55                  60                  


Val His Pro Phe Ile Pro His Arg Leu Glu Glu Gly Tyr Gly Val Leu 
65                  70                  75                  80  


Met Glu Arg Val Pro Glu His Leu Glu Ala Ser Asp Leu Phe Leu Thr 
                85                  90                  95      


Val Asp Cys Gly Ile Thr Asn His Ala Glu Leu Arg Glu Leu Leu Glu 
            100                 105                 110         


Asn Gly Val Glu Val Ile Val Thr Asp His His Thr Pro Gly Lys Thr 
        115                 120                 125             


Pro Pro Pro Gly Leu Val Val His Pro Ala Leu Thr Pro Asp Leu Lys 
    130                 135                 140                 


Glu Lys Pro Thr Gly Ala Gly Val Ala Phe Leu Leu Leu Trp Ala Leu 
145                 150                 155                 160 


His Glu Arg Leu Gly Leu Pro Pro Pro Leu Glu Tyr Ala Asp Leu Ala 
                165                 170                 175     


Ala Val Gly Thr Ile Ala Asp Val Ala Pro Leu Trp Gly Trp Asn Arg 
            180                 185                 190         


Ala Leu Val Lys Glu Gly Leu Ala Arg Ile Pro Ala Ser Ser Trp Val 
        195                 200                 205             


Gly Leu Arg Leu Leu Ala Glu Ala Val Gly Tyr Thr Gly Lys Ala Val 
    210                 215                 220                 


Glu Val Ala Phe Arg Ile Ala Pro Arg Ile Asn Ala Ala Ser Arg Leu 
225                 230                 235                 240 


Gly Glu Ala Glu Lys Ala Leu Arg Leu Leu Leu Thr Asp Asp Ala Ala 
                245                 250                 255     


Glu Ala Gln Ala Leu Val Gly Glu Leu His Arg Leu Asn Ala Arg Arg 
            260                 265                 270         


Gln Thr Leu Glu Glu Ala Met Leu Arg Lys Leu Leu Pro Gln Ala Asp 
        275                 280                 285             


Pro Glu Ala Lys Ala Ile Val Leu Leu Asp Pro Glu Gly His Pro Gly 
    290                 295                 300                 


Val Met Gly Ile Val Ala Ser Arg Ile Leu Glu Ala Thr Leu Arg Pro 
305                 310                 315                 320 


Val Phe Leu Val Ala Gln Gly Lys Gly Thr Val Arg Ser Leu Ala Pro 
                325                 330                 335     


Ile Ser Ala Val Glu Ala Leu Arg Ser Ala Glu Asp Leu Leu Leu Arg 
            340                 345                 350         


Tyr Gly Gly His Lys Glu Ala Ala Gly Phe Ala Met Asp Glu Ala Leu 
        355                 360                 365             


Phe Pro Ala Phe Lys Ala Arg Val Glu Ala Tyr Ala Ala Arg Phe Pro 
    370                 375                 380                 


Asp Pro Val Arg Glu Val Ala Leu Leu Asp Leu Leu Pro Glu Pro Gly 
385                 390                 395                 400 


Leu Leu Pro Gln Val Phe Arg Glu Leu Ala Leu Leu Glu Pro Tyr Gly 
                405                 410                 415     


Glu Gly Asn Pro Glu Pro Leu Phe Leu 
            420                 425 


<210>  16
<211>  738
<212>  DNA
<213>  Bacteriophage lambda

<400>  16
tccggaagcg gctctggtag tggttctggc atgacaccgg acattatcct gcagcgtacc       60

gggatcgatg tgagagctgt cgaacagggg gatgatgcgt ggcacaaatt acggctcggc      120

gtcatcaccg cttcagaagt tcacaacgtg atagcaaaac cccgctccgg aaagaagtgg      180

cctgacatga aaatgtccta cttccacacc ctgcttgctg aggtttgcac cggtgtggct      240

ccggaagtta acgctaaagc actggcctgg ggaaaacagt acgagaacga cgccagaacc      300

ctgtttgaat tcacttccgg cgtgaatgtt actgaatccc cgatcatcta tcgcgacgaa      360

agtatgcgta ccgcctgctc tcccgatggt ttatgcagtg acggcaacgg ccttgaactg      420

aaatgcccgt ttacctcccg ggatttcatg aagttccggc tcggtggttt cgaggccata      480

aagtcagctt acatggccca ggtgcagtac agcatgtggg tgacgcgaaa aaatgcctgg      540

tactttgcca actatgaccc gcgtatgaag cgtgaaggcc tgcattatgt cgtgattgag      600

cgggatgaaa agtacatggc gagttttgac gagatcgtgc cggagttcat cgaaaaaatg      660

gacgaggcac tggctgaaat tggttttgta tttggggagc aatggcgatc tggctctggt      720

tccggcagcg gttccgga                                                    738


<210>  17
<211>  226
<212>  PRT
<213>  Bacteriophage lambda

<400>  17

Met Thr Pro Asp Ile Ile Leu Gln Arg Thr Gly Ile Asp Val Arg Ala 
1               5                   10                  15      


Val Glu Gln Gly Asp Asp Ala Trp His Lys Leu Arg Leu Gly Val Ile 
            20                  25                  30          


Thr Ala Ser Glu Val His Asn Val Ile Ala Lys Pro Arg Ser Gly Lys 
        35                  40                  45              


Lys Trp Pro Asp Met Lys Met Ser Tyr Phe His Thr Leu Leu Ala Glu 
    50                  55                  60                  


Val Cys Thr Gly Val Ala Pro Glu Val Asn Ala Lys Ala Leu Ala Trp 
65                  70                  75                  80  


Gly Lys Gln Tyr Glu Asn Asp Ala Arg Thr Leu Phe Glu Phe Thr Ser 
                85                  90                  95      


Gly Val Asn Val Thr Glu Ser Pro Ile Ile Tyr Arg Asp Glu Ser Met 
            100                 105                 110         


Arg Thr Ala Cys Ser Pro Asp Gly Leu Cys Ser Asp Gly Asn Gly Leu 
        115                 120                 125             


Glu Leu Lys Cys Pro Phe Thr Ser Arg Asp Phe Met Lys Phe Arg Leu 
    130                 135                 140                 


Gly Gly Phe Glu Ala Ile Lys Ser Ala Tyr Met Ala Gln Val Gln Tyr 
145                 150                 155                 160 


Ser Met Trp Val Thr Arg Lys Asn Ala Trp Tyr Phe Ala Asn Tyr Asp 
                165                 170                 175     


Pro Arg Met Lys Arg Glu Gly Leu His Tyr Val Val Ile Glu Arg Asp 
            180                 185                 190         


Glu Lys Tyr Met Ala Ser Phe Asp Glu Ile Val Pro Glu Phe Ile Glu 
        195                 200                 205             


Lys Met Asp Glu Ala Leu Ala Glu Ile Gly Phe Val Phe Gly Glu Gln 
    210                 215                 220                 


Trp Arg 
225     


<210>  18
<211>  760
<212>  PRT
<213>  Methanococcoides burtonii

<400>  18

Met Met Ile Arg Glu Leu Asp Ile Pro Arg Asp Ile Ile Gly Phe Tyr 
1               5                   10                  15      


Glu Asp Ser Gly Ile Lys Glu Leu Tyr Pro Pro Gln Ala Glu Ala Ile 
            20                  25                  30          


Glu Met Gly Leu Leu Glu Lys Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Ile Lys Ala Ile 
    50                  55                  60                  


Arg Glu Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Glu Arg Phe Lys Glu Leu Ala Pro Phe Gly Ile Lys 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Leu Asp Ser Arg Ala Asp Trp Leu Gly 
            100                 105                 110         


Val Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Gly Thr Ser Trp Met Asp Glu Ile Thr Thr Val Val Val Asp 
    130                 135                 140                 


Glu Ile His Leu Leu Asp Ser Lys Asn Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Ile Thr Lys Leu Met Arg Leu Asn Pro Asp Val Gln Val Val Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Arg Glu Met Ala Asp Trp Leu Gly 
            180                 185                 190         


Ala Ala Leu Val Leu Ser Glu Trp Arg Pro Thr Asp Leu His Glu Gly 
        195                 200                 205             


Val Leu Phe Gly Asp Ala Ile Asn Phe Pro Gly Ser Gln Lys Lys Ile 
    210                 215                 220                 


Asp Arg Leu Glu Lys Asp Asp Ala Val Asn Leu Val Leu Asp Thr Ile 
225                 230                 235                 240 


Lys Ala Glu Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Ala Gly Phe Ala Lys Thr Ala Ser Ser Lys Val Ala Lys Ile Leu Asp 
            260                 265                 270         


Asn Asp Ile Met Ile Lys Leu Ala Gly Ile Ala Glu Glu Val Glu Ser 
        275                 280                 285             


Thr Gly Glu Thr Asp Thr Ala Ile Val Leu Ala Asn Cys Ile Arg Lys 
    290                 295                 300                 


Gly Val Ala Phe His His Ala Gly Leu Asn Ser Asn His Arg Lys Leu 
305                 310                 315                 320 


Val Glu Asn Gly Phe Arg Gln Asn Leu Ile Lys Val Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Arg Arg Phe Asp Ser Asn Phe Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro His Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ser Val Leu Leu Ala Lys Thr Tyr Asp Glu Phe 
385                 390                 395                 400 


Ala Gln Leu Met Glu Asn Tyr Val Glu Ala Asp Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Val Asn Gly Phe Ala Ser Thr Arg Gln Glu Leu Phe Asp Phe Phe 
        435                 440                 445             


Gly Ala Thr Phe Phe Ala Tyr Gln Gln Asp Lys Trp Met Leu Glu Glu 
    450                 455                 460                 


Val Ile Asn Asp Cys Leu Glu Phe Leu Ile Asp Lys Ala Met Val Ser 
465                 470                 475                 480 


Glu Thr Glu Asp Ile Glu Asp Ala Ser Lys Leu Phe Leu Arg Gly Thr 
                485                 490                 495     


Arg Leu Gly Ser Leu Val Ser Met Leu Tyr Ile Asp Pro Leu Ser Gly 
            500                 505                 510         


Ser Lys Ile Val Asp Gly Phe Lys Asp Ile Gly Lys Ser Thr Gly Gly 
        515                 520                 525             


Asn Met Gly Ser Leu Glu Asp Asp Lys Gly Asp Asp Ile Thr Val Thr 
    530                 535                 540                 


Asp Met Thr Leu Leu His Leu Val Cys Ser Thr Pro Asp Met Arg Gln 
545                 550                 555                 560 


Leu Tyr Leu Arg Asn Thr Asp Tyr Thr Ile Val Asn Glu Tyr Ile Val 
                565                 570                 575     


Ala His Ser Asp Glu Phe His Glu Ile Pro Asp Lys Leu Lys Glu Thr 
            580                 585                 590         


Asp Tyr Glu Trp Phe Met Gly Glu Val Lys Thr Ala Met Leu Leu Glu 
        595                 600                 605             


Glu Trp Val Thr Glu Val Ser Ala Glu Asp Ile Thr Arg His Phe Asn 
    610                 615                 620                 


Val Gly Glu Gly Asp Ile His Ala Leu Ala Asp Thr Ser Glu Trp Leu 
625                 630                 635                 640 


Met His Ala Ala Ala Lys Leu Ala Glu Leu Leu Gly Val Glu Tyr Ser 
                645                 650                 655     


Ser His Ala Tyr Ser Leu Glu Lys Arg Ile Arg Tyr Gly Ser Gly Leu 
            660                 665                 670         


Asp Leu Met Glu Leu Val Gly Ile Arg Gly Val Gly Arg Val Arg Ala 
        675                 680                 685             


Arg Lys Leu Tyr Asn Ala Gly Phe Val Ser Val Ala Lys Leu Lys Gly 
    690                 695                 700                 


Ala Asp Ile Ser Val Leu Ser Lys Leu Val Gly Pro Lys Val Ala Tyr 
705                 710                 715                 720 


Asn Ile Leu Ser Gly Ile Gly Val Arg Val Asn Asp Lys His Phe Asn 
                725                 730                 735     


Ser Ala Pro Ile Ser Ser Asn Thr Leu Asp Thr Leu Leu Asp Lys Asn 
            740                 745                 750         


Gln Lys Thr Phe Asn Asp Phe Gln 
        755                 760 


<210>  19
<211>  707
<212>  PRT
<213>  Cenarchaeum symbiosum

<400>  19

Met Arg Ile Ser Glu Leu Asp Ile Pro Arg Pro Ala Ile Glu Phe Leu 
1               5                   10                  15      


Glu Gly Glu Gly Tyr Lys Lys Leu Tyr Pro Pro Gln Ala Ala Ala Ala 
            20                  25                  30          


Lys Ala Gly Leu Thr Asp Gly Lys Ser Val Leu Val Ser Ala Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ala Ala Ile Ala Met Ile Ser His Leu 
    50                  55                  60                  


Ser Arg Asn Arg Gly Lys Ala Val Tyr Leu Ser Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ala Glu Lys Phe Ala Glu Phe Gly Lys Ile Gly Gly Ile Pro Leu 
                85                  90                  95      


Gly Arg Pro Val Arg Val Gly Val Ser Thr Gly Asp Phe Glu Lys Ala 
            100                 105                 110         


Gly Arg Ser Leu Gly Asn Asn Asp Ile Leu Val Leu Thr Asn Glu Arg 
        115                 120                 125             


Met Asp Ser Leu Ile Arg Arg Arg Pro Asp Trp Met Asp Glu Val Gly 
    130                 135                 140                 


Leu Val Ile Ala Asp Glu Ile His Leu Ile Gly Asp Arg Ser Arg Gly 
145                 150                 155                 160 


Pro Thr Leu Glu Met Val Leu Thr Lys Leu Arg Gly Leu Arg Ser Ser 
                165                 170                 175     


Pro Gln Val Val Ala Leu Ser Ala Thr Ile Ser Asn Ala Asp Glu Ile 
            180                 185                 190         


Ala Gly Trp Leu Asp Cys Thr Leu Val His Ser Thr Trp Arg Pro Val 
        195                 200                 205             


Pro Leu Ser Glu Gly Val Tyr Gln Asp Gly Glu Val Ala Met Gly Asp 
    210                 215                 220                 


Gly Ser Arg His Glu Val Ala Ala Thr Gly Gly Gly Pro Ala Val Asp 
225                 230                 235                 240 


Leu Ala Ala Glu Ser Val Ala Glu Gly Gly Gln Ser Leu Ile Phe Ala 
                245                 250                 255     


Asp Thr Arg Ala Arg Ser Ala Ser Leu Ala Ala Lys Ala Ser Ala Val 
            260                 265                 270         


Ile Pro Glu Ala Lys Gly Ala Asp Ala Ala Lys Leu Ala Ala Ala Ala 
        275                 280                 285             


Lys Lys Ile Ile Ser Ser Gly Gly Glu Thr Lys Leu Ala Lys Thr Leu 
    290                 295                 300                 


Ala Glu Leu Val Glu Lys Gly Ala Ala Phe His His Ala Gly Leu Asn 
305                 310                 315                 320 


Gln Asp Cys Arg Ser Val Val Glu Glu Glu Phe Arg Ser Gly Arg Ile 
                325                 330                 335     


Arg Leu Leu Ala Ser Thr Pro Thr Leu Ala Ala Gly Val Asn Leu Pro 
            340                 345                 350         


Ala Arg Arg Val Val Ile Ser Ser Val Met Arg Tyr Asn Ser Ser Ser 
        355                 360                 365             


Gly Met Ser Glu Pro Ile Ser Ile Leu Glu Tyr Lys Gln Leu Cys Gly 
    370                 375                 380                 


Arg Ala Gly Arg Pro Gln Tyr Asp Lys Ser Gly Glu Ala Ile Val Val 
385                 390                 395                 400 


Gly Gly Val Asn Ala Asp Glu Ile Phe Asp Arg Tyr Ile Gly Gly Glu 
                405                 410                 415     


Pro Glu Pro Ile Arg Ser Ala Met Val Asp Asp Arg Ala Leu Arg Ile 
            420                 425                 430         


His Val Leu Ser Leu Val Thr Thr Ser Pro Gly Ile Lys Glu Asp Asp 
        435                 440                 445             


Val Thr Glu Phe Phe Leu Gly Thr Leu Gly Gly Gln Gln Ser Gly Glu 
    450                 455                 460                 


Ser Thr Val Lys Phe Ser Val Ala Val Ala Leu Arg Phe Leu Gln Glu 
465                 470                 475                 480 


Glu Gly Met Leu Gly Arg Arg Gly Gly Arg Leu Ala Ala Thr Lys Met 
                485                 490                 495     


Gly Arg Leu Val Ser Arg Leu Tyr Met Asp Pro Met Thr Ala Val Thr 
            500                 505                 510         


Leu Arg Asp Ala Val Gly Glu Ala Ser Pro Gly Arg Met His Thr Leu 
        515                 520                 525             


Gly Phe Leu His Leu Val Ser Glu Cys Ser Glu Phe Met Pro Arg Phe 
    530                 535                 540                 


Ala Leu Arg Gln Lys Asp His Glu Val Ala Glu Met Met Leu Glu Ala 
545                 550                 555                 560 


Gly Arg Gly Glu Leu Leu Arg Pro Val Tyr Ser Tyr Glu Cys Gly Arg 
                565                 570                 575     


Gly Leu Leu Ala Leu His Arg Trp Ile Gly Glu Ser Pro Glu Ala Lys 
            580                 585                 590         


Leu Ala Glu Asp Leu Lys Phe Glu Ser Gly Asp Val His Arg Met Val 
        595                 600                 605             


Glu Ser Ser Gly Trp Leu Leu Arg Cys Ile Trp Glu Ile Ser Lys His 
    610                 615                 620                 


Gln Glu Arg Pro Asp Leu Leu Gly Glu Leu Asp Val Leu Arg Ser Arg 
625                 630                 635                 640 


Val Ala Tyr Gly Ile Lys Ala Glu Leu Val Pro Leu Val Ser Ile Lys 
                645                 650                 655     


Gly Ile Gly Arg Val Arg Ser Arg Arg Leu Phe Arg Gly Gly Ile Lys 
            660                 665                 670         


Gly Pro Gly Asp Leu Ala Ala Val Pro Val Glu Arg Leu Ser Arg Val 
        675                 680                 685             


Glu Gly Ile Gly Ala Thr Leu Ala Asn Asn Ile Lys Ser Gln Leu Arg 
    690                 695                 700                 


Lys Gly Gly 
705         


<210>  20
<211>  720
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  20

Met Lys Val Asp Glu Leu Pro Val Asp Glu Arg Leu Lys Ala Val Leu 
1               5                   10                  15      


Lys Glu Arg Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala Leu 
            20                  25                  30          


Lys Ser Gly Ala Leu Glu Gly Arg Asn Leu Val Leu Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Val Ser Glu Ile Val Met Val Asn Lys Leu 
    50                  55                  60                  


Ile Gln Glu Gly Gly Lys Ala Val Tyr Leu Val Pro Leu Lys Ala Leu 
65                  70                  75                  80  


Ala Glu Glu Lys Tyr Arg Glu Phe Lys Glu Trp Glu Lys Leu Gly Leu 
                85                  90                  95      


Lys Val Ala Ala Thr Thr Gly Asp Tyr Asp Ser Thr Asp Asp Trp Leu 
            100                 105                 110         


Gly Arg Tyr Asp Ile Ile Val Ala Thr Ala Glu Lys Phe Asp Ser Leu 
        115                 120                 125             


Leu Arg His Gly Ala Arg Trp Ile Asn Asp Val Lys Leu Val Val Ala 
    130                 135                 140                 


Asp Glu Val His Leu Ile Gly Ser Tyr Asp Arg Gly Ala Thr Leu Glu 
145                 150                 155                 160 


Met Ile Leu Thr His Met Leu Gly Arg Ala Gln Ile Leu Ala Leu Ser 
                165                 170                 175     


Ala Thr Val Gly Asn Ala Glu Glu Leu Ala Glu Trp Leu Asp Ala Ser 
            180                 185                 190         


Leu Val Val Ser Asp Trp Arg Pro Val Gln Leu Arg Arg Gly Val Phe 
        195                 200                 205             


His Leu Gly Thr Leu Ile Trp Glu Asp Gly Lys Val Glu Ser Tyr Pro 
    210                 215                 220                 


Glu Asn Trp Tyr Ser Leu Val Val Asp Ala Val Lys Arg Gly Lys Gly 
225                 230                 235                 240 


Ala Leu Val Phe Val Asn Thr Arg Arg Ser Ala Glu Lys Glu Ala Leu 
                245                 250                 255     


Ala Leu Ser Lys Leu Val Ser Ser His Leu Thr Lys Pro Glu Lys Arg 
            260                 265                 270         


Ala Leu Glu Ser Leu Ala Ser Gln Leu Glu Asp Asn Pro Thr Ser Glu 
        275                 280                 285             


Lys Leu Lys Arg Ala Leu Arg Gly Gly Val Ala Phe His His Ala Gly 
    290                 295                 300                 


Leu Ser Arg Val Glu Arg Thr Leu Ile Glu Asp Ala Phe Arg Glu Gly 
305                 310                 315                 320 


Leu Ile Lys Val Ile Thr Ala Thr Pro Thr Leu Ser Ala Gly Val Asn 
                325                 330                 335     


Leu Pro Ser Phe Arg Val Ile Ile Arg Asp Thr Lys Arg Tyr Ala Gly 
            340                 345                 350         


Phe Gly Trp Thr Asp Ile Pro Val Leu Glu Ile Gln Gln Met Met Gly 
        355                 360                 365             


Arg Ala Gly Arg Pro Arg Tyr Asp Lys Tyr Gly Glu Ala Ile Ile Val 
    370                 375                 380                 


Ala Arg Thr Asp Glu Pro Gly Lys Leu Met Glu Arg Tyr Ile Arg Gly 
385                 390                 395                 400 


Lys Pro Glu Lys Leu Phe Ser Met Leu Ala Asn Glu Gln Ala Phe Arg 
                405                 410                 415     


Ser Gln Val Leu Ala Leu Ile Thr Asn Phe Gly Ile Arg Ser Phe Pro 
            420                 425                 430         


Glu Leu Val Arg Phe Leu Glu Arg Thr Phe Tyr Ala His Gln Arg Lys 
        435                 440                 445             


Asp Leu Ser Ser Leu Glu Tyr Lys Ala Lys Glu Val Val Tyr Phe Leu 
    450                 455                 460                 


Ile Glu Asn Glu Phe Ile Asp Leu Asp Leu Glu Asp Arg Phe Ile Pro 
465                 470                 475                 480 


Leu Pro Phe Gly Lys Arg Thr Ser Gln Leu Tyr Ile Asp Pro Leu Thr 
                485                 490                 495     


Ala Lys Lys Phe Lys Asp Ala Phe Pro Ala Ile Glu Arg Asn Pro Asn 
            500                 505                 510         


Pro Phe Gly Ile Phe Gln Leu Ile Ala Ser Thr Pro Asp Met Ala Thr 
        515                 520                 525             


Leu Thr Ala Arg Arg Arg Glu Met Glu Asp Tyr Leu Asp Leu Ala Tyr 
    530                 535                 540                 


Glu Leu Glu Asp Lys Leu Tyr Ala Ser Ile Pro Tyr Tyr Glu Asp Ser 
545                 550                 555                 560 


Arg Phe Gln Gly Phe Leu Gly Gln Val Lys Thr Ala Lys Val Leu Leu 
                565                 570                 575     


Asp Trp Ile Asn Glu Val Pro Glu Ala Arg Ile Tyr Glu Thr Tyr Ser 
            580                 585                 590         


Ile Asp Pro Gly Asp Leu Tyr Arg Leu Leu Glu Leu Ala Asp Trp Leu 
        595                 600                 605             


Met Tyr Ser Leu Ile Glu Leu Tyr Lys Leu Phe Glu Pro Lys Glu Glu 
    610                 615                 620                 


Ile Leu Asn Tyr Leu Arg Asp Leu His Leu Arg Leu Arg His Gly Val 
625                 630                 635                 640 


Arg Glu Glu Leu Leu Glu Leu Val Arg Leu Pro Asn Ile Gly Arg Lys 
                645                 650                 655     


Arg Ala Arg Ala Leu Tyr Asn Ala Gly Phe Arg Ser Val Glu Ala Ile 
            660                 665                 670         


Ala Asn Ala Lys Pro Ala Glu Leu Leu Ala Val Glu Gly Ile Gly Ala 
        675                 680                 685             


Lys Ile Leu Asp Gly Ile Tyr Arg His Leu Gly Ile Glu Lys Arg Val 
    690                 695                 700                 


Thr Glu Glu Lys Pro Lys Arg Lys Gly Thr Leu Glu Asp Phe Leu Arg 
705                 710                 715                 720 


<210>  21
<211>  799
<212>  PRT
<213>  Methanospirillum hungatei

<400>  21

Met Glu Ile Ala Ser Leu Pro Leu Pro Asp Ser Phe Ile Arg Ala Cys 
1               5                   10                  15      


His Ala Lys Gly Ile Arg Ser Leu Tyr Pro Pro Gln Ala Glu Cys Ile 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Lys Asn Leu Leu Ile Ser Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Met Ala Met Trp Ser Arg Ile 
    50                  55                  60                  


Ala Ala Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Tyr Asp Glu Phe Ser Lys Lys Gly Val Ile Arg Val Gly 
                85                  90                  95      


Ile Ala Thr Gly Asp Leu Asp Arg Thr Asp Ala Tyr Leu Gly Glu Asn 
            100                 105                 110         


Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu Arg Asn 
        115                 120                 125             


Arg Thr Pro Trp Leu Ser Gln Ile Thr Cys Ile Val Leu Asp Glu Val 
    130                 135                 140                 


His Leu Ile Gly Ser Glu Asn Arg Gly Ala Thr Leu Glu Met Val Ile 
145                 150                 155                 160 


Thr Lys Leu Arg Tyr Thr Asn Pro Val Met Gln Ile Ile Gly Leu Ser 
                165                 170                 175     


Ala Thr Ile Gly Asn Pro Ala Gln Leu Ala Glu Trp Leu Asp Ala Thr 
            180                 185                 190         


Leu Ile Thr Ser Thr Trp Arg Pro Val Asp Leu Arg Gln Gly Val Tyr 
        195                 200                 205             


Tyr Asn Gly Lys Ile Arg Phe Ser Asp Ser Glu Arg Pro Ile Gln Gly 
    210                 215                 220                 


Lys Thr Lys His Asp Asp Leu Asn Leu Cys Leu Asp Thr Ile Glu Glu 
225                 230                 235                 240 


Gly Gly Gln Cys Leu Val Phe Val Ser Ser Arg Arg Asn Ala Glu Gly 
                245                 250                 255     


Phe Ala Lys Lys Ala Ala Gly Ala Leu Lys Ala Gly Ser Pro Asp Ser 
            260                 265                 270         


Lys Ala Leu Ala Gln Glu Leu Arg Arg Leu Arg Asp Arg Asp Glu Gly 
        275                 280                 285             


Asn Val Leu Ala Asp Cys Val Glu Arg Gly Ala Ala Phe His His Ala 
    290                 295                 300                 


Gly Leu Ile Arg Gln Glu Arg Thr Ile Ile Glu Glu Gly Phe Arg Asn 
305                 310                 315                 320 


Gly Tyr Ile Glu Val Ile Ala Ala Thr Pro Thr Leu Ala Ala Gly Leu 
                325                 330                 335     


Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Asp Tyr Asn Arg Phe Ala 
            340                 345                 350         


Ser Gly Leu Gly Met Val Pro Ile Pro Val Gly Glu Tyr His Gln Met 
        355                 360                 365             


Ala Gly Arg Ala Gly Arg Pro His Leu Asp Pro Tyr Gly Glu Ala Val 
    370                 375                 380                 


Leu Leu Ala Lys Asp Ala Pro Ser Val Glu Arg Leu Phe Glu Thr Phe 
385                 390                 395                 400 


Ile Asp Ala Glu Ala Glu Arg Val Asp Ser Gln Cys Val Asp Asp Ala 
                405                 410                 415     


Ser Leu Cys Ala His Ile Leu Ser Leu Ile Ala Thr Gly Phe Ala His 
            420                 425                 430         


Asp Gln Glu Ala Leu Ser Ser Phe Met Glu Arg Thr Phe Tyr Phe Phe 
        435                 440                 445             


Gln His Pro Lys Thr Arg Ser Leu Pro Arg Leu Val Ala Asp Ala Ile 
    450                 455                 460                 


Arg Phe Leu Thr Thr Ala Gly Met Val Glu Glu Arg Glu Asn Thr Leu 
465                 470                 475                 480 


Ser Ala Thr Arg Leu Gly Ser Leu Val Ser Arg Leu Tyr Leu Asn Pro 
                485                 490                 495     


Cys Thr Ala Arg Leu Ile Leu Asp Ser Leu Lys Ser Cys Lys Thr Pro 
            500                 505                 510         


Thr Leu Ile Gly Leu Leu His Val Ile Cys Val Ser Pro Asp Met Gln 
        515                 520                 525             


Arg Leu Tyr Leu Lys Ala Ala Asp Thr Gln Leu Leu Arg Thr Phe Leu 
    530                 535                 540                 


Phe Lys His Lys Asp Asp Leu Ile Leu Pro Leu Pro Phe Glu Gln Glu 
545                 550                 555                 560 


Glu Glu Glu Leu Trp Leu Ser Gly Leu Lys Thr Ala Leu Val Leu Thr 
                565                 570                 575     


Asp Trp Ala Asp Glu Phe Ser Glu Gly Met Ile Glu Glu Arg Tyr Gly 
            580                 585                 590         


Ile Gly Ala Gly Asp Leu Tyr Asn Ile Val Asp Ser Gly Lys Trp Leu 
        595                 600                 605             


Leu His Gly Thr Glu Arg Leu Val Ser Val Glu Met Pro Glu Met Ser 
    610                 615                 620                 


Gln Val Val Lys Thr Leu Ser Val Arg Val His His Gly Val Lys Ser 
625                 630                 635                 640 


Glu Leu Leu Pro Leu Val Ala Leu Arg Asn Ile Gly Arg Val Arg Ala 
                645                 650                 655     


Arg Thr Leu Tyr Asn Ala Gly Tyr Pro Asp Pro Glu Ala Val Ala Arg 
            660                 665                 670         


Ala Gly Leu Ser Thr Ile Ala Arg Ile Ile Gly Glu Gly Ile Ala Arg 
        675                 680                 685             


Gln Val Ile Asp Glu Ile Thr Gly Val Lys Arg Ser Gly Ile His Ser 
    690                 695                 700                 


Ser Asp Asp Asp Tyr Gln Gln Lys Thr Pro Glu Leu Leu Thr Asp Ile 
705                 710                 715                 720 


Pro Gly Ile Gly Lys Lys Met Ala Glu Lys Leu Gln Asn Ala Gly Ile 
                725                 730                 735     


Ile Thr Val Ser Asp Leu Leu Thr Ala Asp Glu Val Leu Leu Ser Asp 
            740                 745                 750         


Val Leu Gly Ala Ala Arg Ala Arg Lys Val Leu Ala Phe Leu Ser Asn 
        755                 760                 765             


Ser Glu Lys Glu Asn Ser Ser Ser Asp Lys Thr Glu Glu Ile Pro Asp 
    770                 775                 780                 


Thr Gln Lys Ile Arg Gly Gln Ser Ser Trp Glu Asp Phe Gly Cys 
785                 790                 795                 


<210>  22
<211>  1756
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Met Ser Ile Ala Gln Val Arg Ser Ala Gly Ser Ala Gly Asn Tyr 
1               5                   10                  15      


Tyr Thr Asp Lys Asp Asn Tyr Tyr Val Leu Gly Ser Met Gly Glu Arg 
            20                  25                  30          


Trp Ala Gly Lys Gly Ala Glu Gln Leu Gly Leu Gln Gly Ser Val Asp 
        35                  40                  45              


Lys Asp Val Phe Thr Arg Leu Leu Glu Gly Arg Leu Pro Asp Gly Ala 
    50                  55                  60                  


Asp Leu Ser Arg Met Gln Asp Gly Ser Asn Lys His Arg Pro Gly Tyr 
65                  70                  75                  80  


Asp Leu Thr Phe Ser Ala Pro Lys Ser Val Ser Met Met Ala Met Leu 
                85                  90                  95      


Gly Gly Asp Lys Arg Leu Ile Asp Ala His Asn Gln Ala Val Asp Phe 
            100                 105                 110         


Ala Val Arg Gln Val Glu Ala Leu Ala Ser Thr Arg Val Met Thr Asp 
        115                 120                 125             


Gly Gln Ser Glu Thr Val Leu Thr Gly Asn Leu Val Met Ala Leu Phe 
    130                 135                 140                 


Asn His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His Ala 
145                 150                 155                 160 


Val Val Ala Asn Val Thr Gln His Asn Gly Glu Trp Lys Thr Leu Ser 
                165                 170                 175     


Ser Asp Lys Val Gly Lys Thr Gly Phe Ile Glu Asn Val Tyr Ala Asn 
            180                 185                 190         


Gln Ile Ala Phe Gly Arg Leu Tyr Arg Glu Lys Leu Lys Glu Gln Val 
        195                 200                 205             


Glu Ala Leu Gly Tyr Glu Thr Glu Val Val Gly Lys His Gly Met Trp 
    210                 215                 220                 


Glu Met Pro Gly Val Pro Val Glu Ala Phe Ser Gly Arg Ser Gln Ala 
225                 230                 235                 240 


Ile Arg Glu Ala Val Gly Glu Asp Ala Ser Leu Lys Ser Arg Asp Val 
                245                 250                 255     


Ala Ala Leu Asp Thr Arg Lys Ser Lys Gln His Val Asp Pro Glu Ile 
            260                 265                 270         


Arg Met Ala Glu Trp Met Gln Thr Leu Lys Glu Thr Gly Phe Asp Ile 
        275                 280                 285             


Arg Ala Tyr Arg Asp Ala Ala Asp Gln Arg Thr Glu Ile Arg Thr Gln 
    290                 295                 300                 


Ala Pro Gly Pro Ala Ser Gln Asp Gly Pro Asp Val Gln Gln Ala Val 
305                 310                 315                 320 


Thr Gln Ala Ile Ala Gly Leu Ser Glu Arg Lys Val Gln Phe Thr Tyr 
                325                 330                 335     


Thr Asp Val Leu Ala Arg Thr Val Gly Ile Leu Pro Pro Glu Asn Gly 
            340                 345                 350         


Val Ile Glu Arg Ala Arg Ala Gly Ile Asp Glu Ala Ile Ser Arg Glu 
        355                 360                 365             


Gln Leu Ile Pro Leu Asp Arg Glu Lys Gly Leu Phe Thr Ser Gly Ile 
    370                 375                 380                 


His Val Leu Asp Glu Leu Ser Val Arg Ala Leu Ser Arg Asp Ile Met 
385                 390                 395                 400 


Lys Gln Asn Arg Val Thr Val His Pro Glu Lys Ser Val Pro Arg Thr 
                405                 410                 415     


Ala Gly Tyr Ser Asp Ala Val Ser Val Leu Ala Gln Asp Arg Pro Ser 
            420                 425                 430         


Leu Ala Ile Val Ser Gly Gln Gly Gly Ala Ala Gly Gln Arg Glu Arg 
        435                 440                 445             


Val Ala Glu Leu Val Met Met Ala Arg Glu Gln Gly Arg Glu Val Gln 
    450                 455                 460                 


Ile Ile Ala Ala Asp Arg Arg Ser Gln Met Asn Leu Lys Gln Asp Glu 
465                 470                 475                 480 


Arg Leu Ser Gly Glu Leu Ile Thr Gly Arg Arg Gln Leu Leu Glu Gly 
                485                 490                 495     


Met Ala Phe Thr Pro Gly Ser Thr Val Ile Val Asp Gln Gly Glu Lys 
            500                 505                 510         


Leu Ser Leu Lys Glu Thr Leu Thr Leu Leu Asp Gly Ala Ala Arg His 
        515                 520                 525             


Asn Val Gln Val Leu Ile Thr Asp Ser Gly Gln Arg Thr Gly Thr Gly 
    530                 535                 540                 


Ser Ala Leu Met Ala Met Lys Asp Ala Gly Val Asn Thr Tyr Arg Trp 
545                 550                 555                 560 


Gln Gly Gly Glu Gln Arg Pro Ala Thr Ile Ile Ser Glu Pro Asp Arg 
                565                 570                 575     


Asn Val Arg Tyr Ala Arg Leu Ala Gly Asp Phe Ala Ala Ser Val Lys 
            580                 585                 590         


Ala Gly Glu Glu Ser Val Ala Gln Val Ser Gly Val Arg Glu Gln Ala 
        595                 600                 605             


Ile Leu Thr Gln Ala Ile Arg Ser Glu Leu Lys Thr Gln Gly Val Leu 
    610                 615                 620                 


Gly His Pro Glu Val Thr Met Thr Ala Leu Ser Pro Val Trp Leu Asp 
625                 630                 635                 640 


Ser Arg Ser Arg Tyr Leu Arg Asp Met Tyr Arg Pro Gly Met Val Met 
                645                 650                 655     


Glu Gln Trp Asn Pro Glu Thr Arg Ser His Asp Arg Tyr Val Ile Asp 
            660                 665                 670         


Arg Val Thr Ala Gln Ser His Ser Leu Thr Leu Arg Asp Ala Gln Gly 
        675                 680                 685             


Glu Thr Gln Val Val Arg Ile Ser Ser Leu Asp Ser Ser Trp Ser Leu 
    690                 695                 700                 


Phe Arg Pro Glu Lys Met Pro Val Ala Asp Gly Glu Arg Leu Arg Val 
705                 710                 715                 720 


Thr Gly Lys Ile Pro Gly Leu Arg Val Ser Gly Gly Asp Arg Leu Gln 
                725                 730                 735     


Val Ala Ser Val Ser Glu Asp Ala Met Thr Val Val Val Pro Gly Arg 
            740                 745                 750         


Ala Glu Pro Ala Ser Leu Pro Val Ser Asp Ser Pro Phe Thr Ala Leu 
        755                 760                 765             


Lys Leu Glu Asn Gly Trp Val Glu Thr Pro Gly His Ser Val Ser Asp 
    770                 775                 780                 


Ser Ala Thr Val Phe Ala Ser Val Thr Gln Met Ala Met Asp Asn Ala 
785                 790                 795                 800 


Thr Leu Asn Gly Leu Ala Arg Ser Gly Arg Asp Val Arg Leu Tyr Ser 
                805                 810                 815     


Ser Leu Asp Glu Thr Arg Thr Ala Glu Lys Leu Ala Arg His Pro Ser 
            820                 825                 830         


Phe Thr Val Val Ser Glu Gln Ile Lys Ala Arg Ala Gly Glu Thr Leu 
        835                 840                 845             


Leu Glu Thr Ala Ile Ser Leu Gln Lys Ala Gly Leu His Thr Pro Ala 
    850                 855                 860                 


Gln Gln Ala Ile His Leu Ala Leu Pro Val Leu Glu Ser Lys Asn Leu 
865                 870                 875                 880 


Ala Phe Ser Met Val Asp Leu Leu Thr Glu Ala Lys Ser Phe Ala Ala 
                885                 890                 895     


Glu Gly Thr Gly Phe Thr Glu Leu Gly Gly Glu Ile Asn Ala Gln Ile 
            900                 905                 910         


Lys Arg Gly Asp Leu Leu Tyr Val Asp Val Ala Lys Gly Tyr Gly Thr 
        915                 920                 925             


Gly Leu Leu Val Ser Arg Ala Ser Tyr Glu Ala Glu Lys Ser Ile Leu 
    930                 935                 940                 


Arg His Ile Leu Glu Gly Lys Glu Ala Val Thr Pro Leu Met Glu Arg 
945                 950                 955                 960 


Val Pro Gly Glu Leu Met Glu Thr Leu Thr Ser Gly Gln Arg Ala Ala 
                965                 970                 975     


Thr Arg Met Ile Leu Glu Thr Ser Asp Arg Phe Thr Val Val Gln Gly 
            980                 985                 990         


Tyr Ala Gly Val Gly Lys Thr Thr  Gln Phe Arg Ala Val  Met Ser Ala 
        995                 1000                 1005             


Val Asn  Met Leu Pro Ala Ser  Glu Arg Pro Arg Val  Val Gly Leu 
    1010                 1015                 1020             


Gly Pro  Thr His Arg Ala Val  Gly Glu Met Arg Ser  Ala Gly Val 
    1025                 1030                 1035             


Asp Ala  Gln Thr Leu Ala Ser  Phe Leu His Asp Thr  Gln Leu Gln 
    1040                 1045                 1050             


Gln Arg  Ser Gly Glu Thr Pro  Asp Phe Ser Asn Thr  Leu Phe Leu 
    1055                 1060                 1065             


Leu Asp  Glu Ser Ser Met Val  Gly Asn Thr Glu Met  Ala Arg Ala 
    1070                 1075                 1080             


Tyr Ala  Leu Ile Ala Ala Gly  Gly Gly Arg Ala Val  Ala Ser Gly 
    1085                 1090                 1095             


Asp Thr  Asp Gln Leu Gln Ala  Ile Ala Pro Gly Gln  Ser Phe Arg 
    1100                 1105                 1110             


Leu Gln  Gln Thr Arg Ser Ala  Ala Asp Val Val Ile  Met Lys Glu 
    1115                 1120                 1125             


Ile Val  Arg Gln Thr Pro Glu  Leu Arg Glu Ala Val  Tyr Ser Leu 
    1130                 1135                 1140             


Ile Asn  Arg Asp Val Glu Arg  Ala Leu Ser Gly Leu  Glu Ser Val 
    1145                 1150                 1155             


Lys Pro  Ser Gln Val Pro Arg  Leu Glu Gly Ala Trp  Ala Pro Glu 
    1160                 1165                 1170             


His Ser  Val Thr Glu Phe Ser  His Ser Gln Glu Ala  Lys Leu Ala 
    1175                 1180                 1185             


Glu Ala  Gln Gln Lys Ala Met  Leu Lys Gly Glu Ala  Phe Pro Asp 
    1190                 1195                 1200             


Ile Pro  Met Thr Leu Tyr Glu  Ala Ile Val Arg Asp  Tyr Thr Gly 
    1205                 1210                 1215             


Arg Thr  Pro Glu Ala Arg Glu  Gln Thr Leu Ile Val  Thr His Leu 
    1220                 1225                 1230             


Asn Glu  Asp Arg Arg Val Leu  Asn Ser Met Ile His  Asp Ala Arg 
    1235                 1240                 1245             


Glu Lys  Ala Gly Glu Leu Gly  Lys Glu Gln Val Met  Val Pro Val 
    1250                 1255                 1260             


Leu Asn  Thr Ala Asn Ile Arg  Asp Gly Glu Leu Arg  Arg Leu Ser 
    1265                 1270                 1275             


Thr Trp  Glu Lys Asn Pro Asp  Ala Leu Ala Leu Val  Asp Asn Val 
    1280                 1285                 1290             


Tyr His  Arg Ile Ala Gly Ile  Ser Lys Asp Asp Gly  Leu Ile Thr 
    1295                 1300                 1305             


Leu Gln  Asp Ala Glu Gly Asn  Thr Arg Leu Ile Ser  Pro Arg Glu 
    1310                 1315                 1320             


Ala Val  Ala Glu Gly Val Thr  Leu Tyr Thr Pro Asp  Lys Ile Arg 
    1325                 1330                 1335             


Val Gly  Thr Gly Asp Arg Met  Arg Phe Thr Lys Ser  Asp Arg Glu 
    1340                 1345                 1350             


Arg Gly  Tyr Val Ala Asn Ser  Val Trp Thr Val Thr  Ala Val Ser 
    1355                 1360                 1365             


Gly Asp  Ser Val Thr Leu Ser  Asp Gly Gln Gln Thr  Arg Val Ile 
    1370                 1375                 1380             


Arg Pro  Gly Gln Glu Arg Ala  Glu Gln His Ile Asp  Leu Ala Tyr 
    1385                 1390                 1395             


Ala Ile  Thr Ala His Gly Ala  Gln Gly Ala Ser Glu  Thr Phe Ala 
    1400                 1405                 1410             


Ile Ala  Leu Glu Gly Thr Glu  Gly Asn Arg Lys Leu  Met Ala Gly 
    1415                 1420                 1425             


Phe Glu  Ser Ala Tyr Val Ala  Leu Ser Arg Met Lys  Gln His Val 
    1430                 1435                 1440             


Gln Val  Tyr Thr Asp Asn Arg  Gln Gly Trp Thr Asp  Ala Ile Asn 
    1445                 1450                 1455             


Asn Ala  Val Gln Lys Gly Thr  Ala His Asp Val Leu  Glu Pro Lys 
    1460                 1465                 1470             


Pro Asp  Arg Glu Val Met Asn  Ala Gln Arg Leu Phe  Ser Thr Ala 
    1475                 1480                 1485             


Arg Glu  Leu Arg Asp Val Ala  Ala Gly Arg Ala Val  Leu Arg Gln 
    1490                 1495                 1500             


Ala Gly  Leu Ala Gly Gly Asp  Ser Pro Ala Arg Phe  Ile Ala Pro 
    1505                 1510                 1515             


Gly Arg  Lys Tyr Pro Gln Pro  Tyr Val Ala Leu Pro  Ala Phe Asp 
    1520                 1525                 1530             


Arg Asn  Gly Lys Ser Ala Gly  Ile Trp Leu Asn Pro  Leu Thr Thr 
    1535                 1540                 1545             


Asp Asp  Gly Asn Gly Leu Arg  Gly Phe Ser Gly Glu  Gly Arg Val 
    1550                 1555                 1560             


Lys Gly  Ser Gly Asp Ala Gln  Phe Val Ala Leu Gln  Gly Ser Arg 
    1565                 1570                 1575             


Asn Gly  Glu Ser Leu Leu Ala  Asp Asn Met Gln Asp  Gly Val Arg 
    1580                 1585                 1590             


Ile Ala  Arg Asp Asn Pro Asp  Ser Gly Val Val Val  Arg Ile Ala 
    1595                 1600                 1605             


Gly Glu  Gly Arg Pro Trp Asn  Pro Gly Ala Ile Thr  Gly Gly Arg 
    1610                 1615                 1620             


Val Trp  Gly Asp Ile Pro Asp  Asn Ser Val Gln Pro  Gly Ala Gly 
    1625                 1630                 1635             


Asn Gly  Glu Pro Val Thr Ala  Glu Val Leu Ala Gln  Arg Gln Ala 
    1640                 1645                 1650             


Glu Glu  Ala Ile Arg Arg Glu  Thr Glu Arg Arg Ala  Asp Glu Ile 
    1655                 1660                 1665             


Val Arg  Lys Met Ala Glu Asn  Lys Pro Asp Leu Pro  Asp Gly Lys 
    1670                 1675                 1680             


Thr Glu  Leu Ala Val Arg Asp  Ile Ala Gly Gln Glu  Arg Asp Arg 
    1685                 1690                 1695             


Ser Ala  Ile Ser Glu Arg Glu  Thr Ala Leu Pro Glu  Ser Val Leu 
    1700                 1705                 1710             


Arg Glu  Ser Gln Arg Glu Arg  Glu Ala Val Arg Glu  Val Ala Arg 
    1715                 1720                 1725             


Glu Asn  Leu Leu Gln Glu Arg  Leu Gln Gln Met Glu  Arg Asp Met 
    1730                 1735                 1740             


Val Arg  Asp Leu Gln Lys Glu  Lys Thr Leu Gly Gly  Asp 
    1745                 1750                 1755     


<210>  23
<211>  726
<212>  PRT
<213>  Methanococcoides burtonii

<400>  23

Met Ser Asp Lys Pro Ala Phe Met Lys Tyr Phe Thr Gln Ser Ser Cys 
1               5                   10                  15      


Tyr Pro Asn Gln Gln Glu Ala Met Asp Arg Ile His Ser Ala Leu Met 
            20                  25                  30          


Gln Gln Gln Leu Val Leu Phe Glu Gly Ala Cys Gly Thr Gly Lys Thr 
        35                  40                  45              


Leu Ser Ala Leu Val Pro Ala Leu His Val Gly Lys Met Leu Gly Lys 
    50                  55                  60                  


Thr Val Ile Ile Ala Thr Asn Val His Gln Gln Met Val Gln Phe Ile 
65                  70                  75                  80  


Asn Glu Ala Arg Asp Ile Lys Lys Val Gln Asp Val Lys Val Ala Val 
                85                  90                  95      


Ile Lys Gly Lys Thr Ala Met Cys Pro Gln Glu Ala Asp Tyr Glu Glu 
            100                 105                 110         


Cys Ser Val Lys Arg Glu Asn Thr Phe Glu Leu Met Glu Thr Glu Arg 
        115                 120                 125             


Glu Ile Tyr Leu Lys Arg Gln Glu Leu Asn Ser Ala Arg Asp Ser Tyr 
    130                 135                 140                 


Lys Lys Ser His Asp Pro Ala Phe Val Thr Leu Arg Asp Glu Leu Ser 
145                 150                 155                 160 


Lys Glu Ile Asp Ala Val Glu Glu Lys Ala Arg Gly Leu Arg Asp Arg 
                165                 170                 175     


Ala Cys Asn Asp Leu Tyr Glu Val Leu Arg Ser Asp Ser Glu Lys Phe 
            180                 185                 190         


Arg Glu Trp Leu Tyr Lys Glu Val Arg Ser Pro Glu Glu Ile Asn Asp 
        195                 200                 205             


His Ala Ile Lys Asp Gly Met Cys Gly Tyr Glu Leu Val Lys Arg Glu 
    210                 215                 220                 


Leu Lys His Ala Asp Leu Leu Ile Cys Asn Tyr His His Val Leu Asn 
225                 230                 235                 240 


Pro Asp Ile Phe Ser Thr Val Leu Gly Trp Ile Glu Lys Glu Pro Gln 
                245                 250                 255     


Glu Thr Ile Val Ile Phe Asp Glu Ala His Asn Leu Glu Ser Ala Ala 
            260                 265                 270         


Arg Ser His Ser Ser Leu Ser Leu Thr Glu His Ser Ile Glu Lys Ala 
        275                 280                 285             


Ile Thr Glu Leu Glu Ala Asn Leu Asp Leu Leu Ala Asp Asp Asn Ile 
    290                 295                 300                 


His Asn Leu Phe Asn Ile Phe Leu Glu Val Ile Ser Asp Thr Tyr Asn 
305                 310                 315                 320 


Ser Arg Phe Lys Phe Gly Glu Arg Glu Arg Val Arg Lys Asn Trp Tyr 
                325                 330                 335     


Asp Ile Arg Ile Ser Asp Pro Tyr Glu Arg Asn Asp Ile Val Arg Gly 
            340                 345                 350         


Lys Phe Leu Arg Gln Ala Lys Gly Asp Phe Gly Glu Lys Asp Asp Ile 
        355                 360                 365             


Gln Ile Leu Leu Ser Glu Ala Ser Glu Leu Gly Ala Lys Leu Asp Glu 
    370                 375                 380                 


Thr Tyr Arg Asp Gln Tyr Lys Lys Gly Leu Ser Ser Val Met Lys Arg 
385                 390                 395                 400 


Ser His Ile Arg Tyr Val Ala Asp Phe Met Ser Ala Tyr Ile Glu Leu 
                405                 410                 415     


Ser His Asn Leu Asn Tyr Tyr Pro Ile Leu Asn Val Arg Arg Asp Met 
            420                 425                 430         


Asn Asp Glu Ile Tyr Gly Arg Val Glu Leu Phe Thr Cys Ile Pro Lys 
        435                 440                 445             


Asn Val Thr Glu Pro Leu Phe Asn Ser Leu Phe Ser Val Ile Leu Met 
    450                 455                 460                 


Ser Ala Thr Leu His Pro Phe Glu Met Val Lys Lys Thr Leu Gly Ile 
465                 470                 475                 480 


Thr Arg Asp Thr Cys Glu Met Ser Tyr Gly Thr Ser Phe Pro Glu Glu 
                485                 490                 495     


Lys Arg Leu Ser Ile Ala Val Ser Ile Pro Pro Leu Phe Ala Lys Asn 
            500                 505                 510         


Arg Asp Asp Arg His Val Thr Glu Leu Leu Glu Gln Val Leu Leu Asp 
        515                 520                 525             


Ser Ile Glu Asn Ser Lys Gly Asn Val Ile Leu Phe Phe Gln Ser Ala 
    530                 535                 540                 


Phe Glu Ala Lys Arg Tyr Tyr Ser Lys Ile Glu Pro Leu Val Asn Val 
545                 550                 555                 560 


Pro Val Phe Leu Asp Glu Val Gly Ile Ser Ser Gln Asp Val Arg Glu 
                565                 570                 575     


Glu Phe Phe Ser Ile Gly Glu Glu Asn Gly Lys Ala Val Leu Leu Ser 
            580                 585                 590         


Tyr Leu Trp Gly Thr Leu Ser Glu Gly Ile Asp Tyr Arg Asp Gly Arg 
        595                 600                 605             


Gly Arg Thr Val Ile Ile Ile Gly Val Gly Tyr Pro Ala Leu Asn Asp 
    610                 615                 620                 


Arg Met Asn Ala Val Glu Ser Ala Tyr Asp His Val Phe Gly Tyr Gly 
625                 630                 635                 640 


Ala Gly Trp Glu Phe Ala Ile Gln Val Pro Thr Ile Arg Lys Ile Arg 
                645                 650                 655     


Gln Ala Met Gly Arg Val Val Arg Ser Pro Thr Asp Tyr Gly Ala Arg 
            660                 665                 670         


Ile Leu Leu Asp Gly Arg Phe Leu Thr Asp Ser Lys Lys Arg Phe Gly 
        675                 680                 685             


Lys Phe Ser Val Phe Glu Val Phe Pro Pro Ala Glu Arg Ser Glu Phe 
    690                 695                 700                 


Val Asp Val Asp Pro Glu Lys Val Lys Tyr Ser Leu Met Asn Phe Phe 
705                 710                 715                 720 


Met Asp Asn Asp Glu Gln 
                725     


<210>  24
<211>  439
<212>  PRT
<213>  Dickeya dadantii

<400>  24

Met Thr Phe Asp Asp Leu Thr Glu Gly Gln Lys Asn Ala Phe Asn Ile 
1               5                   10                  15      


Val Met Lys Ala Ile Lys Glu Lys Lys His His Val Thr Ile Asn Gly 
            20                  25                  30          


Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Ile Ile Glu Ala 
        35                  40                  45              


Leu Ile Ser Thr Gly Glu Thr Gly Ile Ile Leu Ala Ala Pro Thr His 
    50                  55                  60                  


Ala Ala Lys Lys Ile Leu Ser Lys Leu Ser Gly Lys Glu Ala Ser Thr 
65                  70                  75                  80  


Ile His Ser Ile Leu Lys Ile Asn Pro Val Thr Tyr Glu Glu Asn Val 
                85                  90                  95      


Leu Phe Glu Gln Lys Glu Val Pro Asp Leu Ala Lys Cys Arg Val Leu 
            100                 105                 110         


Ile Cys Asp Glu Val Ser Met Tyr Asp Arg Lys Leu Phe Lys Ile Leu 
        115                 120                 125             


Leu Ser Thr Ile Pro Pro Trp Cys Thr Ile Ile Gly Ile Gly Asp Asn 
    130                 135                 140                 


Lys Gln Ile Arg Pro Val Asp Pro Gly Glu Asn Thr Ala Tyr Ile Ser 
145                 150                 155                 160 


Pro Phe Phe Thr His Lys Asp Phe Tyr Gln Cys Glu Leu Thr Glu Val 
                165                 170                 175     


Lys Arg Ser Asn Ala Pro Ile Ile Asp Val Ala Thr Asp Val Arg Asn 
            180                 185                 190         


Gly Lys Trp Ile Tyr Asp Lys Val Val Asp Gly His Gly Val Arg Gly 
        195                 200                 205             


Phe Thr Gly Asp Thr Ala Leu Arg Asp Phe Met Val Asn Tyr Phe Ser 
    210                 215                 220                 


Ile Val Lys Ser Leu Asp Asp Leu Phe Glu Asn Arg Val Met Ala Phe 
225                 230                 235                 240 


Thr Asn Lys Ser Val Asp Lys Leu Asn Ser Ile Ile Arg Lys Lys Ile 
                245                 250                 255     


Phe Glu Thr Asp Lys Asp Phe Ile Val Gly Glu Ile Ile Val Met Gln 
            260                 265                 270         


Glu Pro Leu Phe Lys Thr Tyr Lys Ile Asp Gly Lys Pro Val Ser Glu 
        275                 280                 285             


Ile Ile Phe Asn Asn Gly Gln Leu Val Arg Ile Ile Glu Ala Glu Tyr 
    290                 295                 300                 


Thr Ser Thr Phe Val Lys Ala Arg Gly Val Pro Gly Glu Tyr Leu Ile 
305                 310                 315                 320 


Arg His Trp Asp Leu Thr Val Glu Thr Tyr Gly Asp Asp Glu Tyr Tyr 
                325                 330                 335     


Arg Glu Lys Ile Lys Ile Ile Ser Ser Asp Glu Glu Leu Tyr Lys Phe 
            340                 345                 350         


Asn Leu Phe Leu Gly Lys Thr Ala Glu Thr Tyr Lys Asn Trp Asn Lys 
        355                 360                 365             


Gly Gly Lys Ala Pro Trp Ser Asp Phe Trp Asp Ala Lys Ser Gln Phe 
    370                 375                 380                 


Ser Lys Val Lys Ala Leu Pro Ala Ser Thr Phe His Lys Ala Gln Gly 
385                 390                 395                 400 


Met Ser Val Asp Arg Ala Phe Ile Tyr Thr Pro Cys Ile His Tyr Ala 
                405                 410                 415     


Asp Val Glu Leu Ala Gln Gln Leu Leu Tyr Val Gly Val Thr Arg Gly 
            420                 425                 430         


Arg Tyr Asp Val Phe Tyr Val 
        435                 


<210>  25
<211>  970
<212>  PRT
<213>  Unknown

<400>  25

Met Leu Ser Val Ala Asn Val Arg Ser Pro Ser Ala Ala Ala Ser Tyr 
1               5                   10                  15      


Phe Ala Ser Asp Asn Tyr Tyr Ala Ser Ala Asp Ala Asp Arg Ser Gly 
            20                  25                  30          


Gln Trp Ile Gly Asp Gly Ala Lys Arg Leu Gly Leu Glu Gly Lys Val 
        35                  40                  45              


Glu Ala Arg Ala Phe Asp Ala Leu Leu Arg Gly Glu Leu Pro Asp Gly 
    50                  55                  60                  


Ser Ser Val Gly Asn Pro Gly Gln Ala His Arg Pro Gly Thr Asp Leu 
65                  70                  75                  80  


Thr Phe Ser Val Pro Lys Ser Trp Ser Leu Leu Ala Leu Val Gly Lys 
                85                  90                  95      


Asp Glu Arg Ile Ile Ala Ala Tyr Arg Glu Ala Val Val Glu Ala Leu 
            100                 105                 110         


His Trp Ala Glu Lys Asn Ala Ala Glu Thr Arg Val Val Glu Lys Gly 
        115                 120                 125             


Met Val Val Thr Gln Ala Thr Gly Asn Leu Ala Ile Gly Leu Phe Gln 
    130                 135                 140                 


His Asp Thr Asn Arg Asn Gln Glu Pro Asn Leu His Phe His Ala Val 
145                 150                 155                 160 


Ile Ala Asn Val Thr Gln Gly Lys Asp Gly Lys Trp Arg Thr Leu Lys 
                165                 170                 175     


Asn Asp Arg Leu Trp Gln Leu Asn Thr Thr Leu Asn Ser Ile Ala Met 
            180                 185                 190         


Ala Arg Phe Arg Val Ala Val Glu Lys Leu Gly Tyr Glu Pro Gly Pro 
        195                 200                 205             


Val Leu Lys His Gly Asn Phe Glu Ala Arg Gly Ile Ser Arg Glu Gln 
    210                 215                 220                 


Val Met Ala Phe Ser Thr Arg Arg Lys Glu Val Leu Glu Ala Arg Arg 
225                 230                 235                 240 


Gly Pro Gly Leu Asp Ala Gly Arg Ile Ala Ala Leu Asp Thr Arg Ala 
                245                 250                 255     


Ser Lys Glu Gly Ile Glu Asp Arg Ala Thr Leu Ser Lys Gln Trp Ser 
            260                 265                 270         


Glu Ala Ala Gln Ser Ile Gly Leu Asp Leu Lys Pro Leu Val Asp Arg 
        275                 280                 285             


Ala Arg Thr Lys Ala Leu Gly Gln Gly Met Glu Ala Thr Arg Ile Gly 
    290                 295                 300                 


Ser Leu Val Glu Arg Gly Arg Ala Trp Leu Ser Arg Phe Ala Ala His 
305                 310                 315                 320 


Val Arg Gly Asp Pro Ala Asp Pro Leu Val Pro Pro Ser Val Leu Lys 
                325                 330                 335     


Gln Asp Arg Gln Thr Ile Ala Ala Ala Gln Ala Val Ala Ser Ala Val 
            340                 345                 350         


Arg His Leu Ser Gln Arg Glu Ala Ala Phe Glu Arg Thr Ala Leu Tyr 
        355                 360                 365             


Lys Ala Ala Leu Asp Phe Gly Leu Pro Thr Thr Ile Ala Asp Val Glu 
    370                 375                 380                 


Lys Arg Thr Arg Ala Leu Val Arg Ser Gly Asp Leu Ile Ala Gly Lys 
385                 390                 395                 400 


Gly Glu His Lys Gly Trp Leu Ala Ser Arg Asp Ala Val Val Thr Glu 
                405                 410                 415     


Gln Arg Ile Leu Ser Glu Val Ala Ala Gly Lys Gly Asp Ser Ser Pro 
            420                 425                 430         


Ala Ile Thr Pro Gln Lys Ala Ala Ala Ser Val Gln Ala Ala Ala Leu 
        435                 440                 445             


Thr Gly Gln Gly Phe Arg Leu Asn Glu Gly Gln Leu Ala Ala Ala Arg 
    450                 455                 460                 


Leu Ile Leu Ile Ser Lys Asp Arg Thr Ile Ala Val Gln Gly Ile Ala 
465                 470                 475                 480 


Gly Ala Gly Lys Ser Ser Val Leu Lys Pro Val Ala Glu Val Leu Arg 
                485                 490                 495     


Asp Glu Gly His Pro Val Ile Gly Leu Ala Ile Gln Asn Thr Leu Val 
            500                 505                 510         


Gln Met Leu Glu Arg Asp Thr Gly Ile Gly Ser Gln Thr Leu Ala Arg 
        515                 520                 525             


Phe Leu Gly Gly Trp Asn Lys Leu Leu Asp Asp Pro Gly Asn Val Ala 
    530                 535                 540                 


Leu Arg Ala Glu Ala Gln Ala Ser Leu Lys Asp His Val Leu Val Leu 
545                 550                 555                 560 


Asp Glu Ala Ser Met Val Ser Asn Glu Asp Lys Glu Lys Leu Val Arg 
                565                 570                 575     


Leu Ala Asn Leu Ala Gly Val His Arg Leu Val Leu Ile Gly Asp Arg 
            580                 585                 590         


Lys Gln Leu Gly Ala Val Asp Ala Gly Lys Pro Phe Ala Leu Leu Gln 
        595                 600                 605             


Arg Ala Gly Ile Ala Arg Ala Glu Met Ala Thr Asn Leu Arg Ala Arg 
    610                 615                 620                 


Asp Pro Val Val Arg Glu Ala Gln Ala Ala Ala Gln Ala Gly Asp Val 
625                 630                 635                 640 


Arg Lys Ala Leu Arg His Leu Lys Ser His Thr Val Glu Ala Arg Gly 
                645                 650                 655     


Asp Gly Ala Gln Val Ala Ala Glu Thr Trp Leu Ala Leu Asp Lys Glu 
            660                 665                 670         


Thr Arg Ala Arg Thr Ser Ile Tyr Ala Ser Gly Arg Ala Ile Arg Ser 
        675                 680                 685             


Ala Val Asn Ala Ala Val Gln Gln Gly Leu Leu Ala Ser Arg Glu Ile 
    690                 695                 700                 


Gly Pro Ala Lys Met Lys Leu Glu Val Leu Asp Arg Val Asn Thr Thr 
705                 710                 715                 720 


Arg Glu Glu Leu Arg His Leu Pro Ala Tyr Arg Ala Gly Arg Val Leu 
                725                 730                 735     


Glu Val Ser Arg Lys Gln Gln Ala Leu Gly Leu Phe Ile Gly Glu Tyr 
            740                 745                 750         


Arg Val Ile Gly Gln Asp Arg Lys Gly Lys Leu Val Glu Val Glu Asp 
        755                 760                 765             


Lys Arg Gly Lys Arg Phe Arg Phe Asp Pro Ala Arg Ile Arg Ala Gly 
    770                 775                 780                 


Lys Gly Asp Asp Asn Leu Thr Leu Leu Glu Pro Arg Lys Leu Glu Ile 
785                 790                 795                 800 


His Glu Gly Asp Arg Ile Arg Trp Thr Arg Asn Asp His Arg Arg Gly 
                805                 810                 815     


Leu Phe Asn Ala Asp Gln Ala Arg Val Val Glu Ile Ala Asn Gly Lys 
            820                 825                 830         


Val Thr Phe Glu Thr Ser Lys Gly Asp Leu Val Glu Leu Lys Lys Asp 
        835                 840                 845             


Asp Pro Met Leu Lys Arg Ile Asp Leu Ala Tyr Ala Leu Asn Val His 
    850                 855                 860                 


Met Ala Gln Gly Leu Thr Ser Asp Arg Gly Ile Ala Val Met Asp Ser 
865                 870                 875                 880 


Arg Glu Arg Asn Leu Ser Asn Gln Lys Thr Phe Leu Val Thr Val Thr 
                885                 890                 895     


Arg Leu Arg Asp His Leu Thr Leu Val Val Asp Ser Ala Asp Lys Leu 
            900                 905                 910         


Gly Ala Ala Val Ala Arg Asn Lys Gly Glu Lys Ala Ser Ala Ile Glu 
        915                 920                 925             


Val Thr Gly Ser Val Lys Pro Thr Ala Thr Lys Gly Ser Gly Val Asp 
    930                 935                 940                 


Gln Pro Lys Ser Val Glu Ala Asn Lys Ala Glu Lys Glu Leu Thr Arg 
945                 950                 955                 960 


Ser Lys Ser Lys Thr Leu Asp Phe Gly Ile 
                965                 970 


<210>  26
<211>  262
<212>  PRT
<213>  yokenella regensburgei

<400>  26

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Arg Asp Leu Thr His Leu Pro Leu Pro Ser Gly 
            20                  25                  30          


Lys Val Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Val Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Asp Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Gln Ser Leu Thr Ala Ala Asn Val Met Ile Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Val Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Tyr Leu Ile Asn Asp Gly Ile Glu Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Gln Lys Ala Asp Val Asp Asn Pro Ile Leu Ala Arg Tyr Arg Asn Met 
                245                 250                 255     


Ser Ala Pro Pro Glu Ser 
            260         


<210>  27
<211>  262
<212>  PRT
<213>  cronobacter pulveris

<400>  27

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Arg Asp Leu Thr Asn Leu Pro Asp Pro Lys Gly 
            20                  25                  30          


Lys Leu Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ser Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Glu Asn Asn Arg Met Pro 
            100                 105                 110         


Leu Gln Ser Leu Val Ala Ala Asn Val Met Ile Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Gly Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Ala 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile His Leu Ile Asn Asp Gly Ile Asn Arg Gly Leu Trp Glu Leu Lys 
225                 230                 235                 240 


Asn Lys Gly Asp Ala Lys Asn Thr Ile Leu Ala Lys Tyr Arg Ser Met 
                245                 250                 255     


Ala Val Pro Pro Glu Ser 
            260         


<210>  28
<211>  262
<212>  PRT
<213>  rahnella aquatilis

<400>  28

Cys Leu Thr Ala Ala Pro Lys Glu Ala Ala Arg Pro Thr Leu Leu Pro 
1               5                   10                  15      


Arg Ala Pro Ser Tyr Thr Asp Leu Thr His Leu Pro Ser Pro Gln Gly 
            20                  25                  30          


Arg Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Cys Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Ser Ala Leu Lys Asp Ser Lys Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Ser Val Ala Ile Asn Asn Gln Arg Pro 
            100                 105                 110         


Leu Ser Ser Leu Val Ala Ala Asn Ile Leu Ile Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Ser Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Ala Val Asp Val Asn Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Leu Gly Tyr Thr Thr 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Ser Gly Val 
    210                 215                 220                 


Ile Tyr Leu Val Asn Asp Gly Ile Glu Arg Asn Leu Trp Gln Leu Gln 
225                 230                 235                 240 


Asn Pro Ser Glu Ile Asn Ser Pro Ile Leu Gln Arg Tyr Lys Asn Asn 
                245                 250                 255     


Ile Val Pro Ala Glu Ser 
            260         


<210>  29
<211>  259
<212>  PRT
<213>  kluyvera ascobata

<400>  29

Cys Ile Thr Ser Pro Pro Lys Gln Ala Ala Lys Pro Thr Leu Leu Pro 
1               5                   10                  15      


Arg Ser Gln Ser Tyr Gln Asp Leu Thr His Leu Pro Glu Pro Gln Gly 
            20                  25                  30          


Arg Leu Phe Val Ser Val Tyr Asn Ile Ser Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ser Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Ser Ala Leu Lys Asp Ser Asn Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Val Asn Asn Arg Thr Gln 
            100                 105                 110         


Leu Pro Ser Leu Val Ala Ala Asn Ile Leu Ile Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Ala Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Ser Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Phe Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Tyr Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Val Gly Tyr Thr Val 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Tyr Leu Val Asn Asp Gly Ile Ser Arg Asn Leu Trp Gln Leu Lys 
225                 230                 235                 240 


Asn Ala Ser Asp Ile Asn Ser Pro Val Leu Glu Lys Tyr Lys Ser Ile 
                245                 250                 255     


Ile Val Pro 
            


<210>  30
<211>  259
<212>  PRT
<213>  hafnia alvei

<400>  30

Cys Leu Thr Ala Pro Pro Lys Gln Ala Ala Lys Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Gln Asp Leu Thr His Leu Pro Glu Pro Ala Gly 
            20                  25                  30          


Lys Leu Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Ser Ala Leu Lys Asp Ser Gly Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Ala Ala Val Asn Asn Gln His Gln 
            100                 105                 110         


Leu Ser Ser Leu Val Ala Ala Asn Val Leu Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Ala Gly Ala Arg Phe Phe 
    130                 135                 140                 


Gly Ile Gly Ala Ser Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asp Val Asn Thr Gly Gln Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Tyr Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ile Gly Tyr Thr Thr 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Val Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Tyr Leu Val Asn Asp Gly Ile Asn Arg Asn Leu Trp Thr Leu Lys 
225                 230                 235                 240 


Asn Pro Gln Asp Ala Lys Ser Ser Val Leu Glu Arg Tyr Lys Ser Thr 
                245                 250                 255     


Ile Val Pro 
            


<210>  31
<211>  255
<212>  PRT
<213>  Enterobacteriaceae bacterium

<400>  31

Cys Ile Thr Thr Pro Pro Gln Glu Ala Ala Lys Pro Thr Leu Leu Pro 
1               5                   10                  15      


Arg Asp Ala Thr Tyr Lys Asp Leu Val Ser Leu Pro Gln Pro Arg Gly 
            20                  25                  30          


Lys Ile Tyr Val Ala Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Gln Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ser Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Ser Ser Leu Lys Asp Ser Arg Trp Phe Val Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Asn Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Gln Asn Gly Thr Val Gly Asp Asn Asn Ala Ser Pro 
            100                 105                 110         


Leu Pro Ser Leu Tyr Ser Ala Asn Val Ile Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Ala Ser Asn Val Lys Thr Gly Gly Phe Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Gly Ser Thr Gln Tyr Gln Leu Asp Gln Val Ala Val Asn 
145                 150                 155                 160 


Leu Arg Ile Val Asn Val His Thr Gly Glu Val Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Ile Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Ala Gly Phe Thr Thr 
        195                 200                 205             


Asn Glu Pro Val Met Thr Cys Leu Met Ser Ala Ile Glu Glu Gly Val 
    210                 215                 220                 


Ile His Leu Ile Asn Asp Gly Ile Asn Lys Lys Leu Trp Ala Leu Ser 
225                 230                 235                 240 


Asn Ala Ala Asp Ile Asn Ser Glu Val Leu Thr Arg Tyr Arg Lys 
                245                 250                 255 


<210>  32
<211>  258
<212>  PRT
<213>  plesiomonas shigelloides

<400>  32

Ile Thr Glu Val Pro Lys Glu Ala Ala Lys Pro Thr Leu Met Pro Arg 
1               5                   10                  15      


Ala Ser Thr Tyr Lys Asp Leu Val Ala Leu Pro Lys Pro Asn Gly Lys 
            20                  25                  30          


Ile Ile Val Ser Val Tyr Ser Val Gln Asp Glu Thr Gly Gln Phe Lys 
        35                  40                  45              


Pro Leu Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Gly Asn 
    50                  55                  60                  


Ala Met Leu Thr Ser Ala Leu Lys Asp Ser Gly Trp Phe Val Pro Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile Arg 
                85                  90                  95      


Ala Ala Gln Glu Asn Gly Thr Val Ala Ala Asn Asn Gln Gln Pro Leu 
            100                 105                 110         


Pro Ser Leu Leu Ser Ala Asn Val Val Ile Glu Gly Ala Ile Ile Gly 
        115                 120                 125             


Tyr Asp Ser Asp Ile Lys Thr Gly Gly Ala Gly Ala Arg Tyr Phe Gly 
    130                 135                 140                 


Ile Gly Ala Asp Gly Lys Tyr Arg Val Asp Gln Val Ala Val Asn Leu 
145                 150                 155                 160 


Arg Ala Val Asp Val Arg Thr Gly Glu Val Leu Leu Ser Val Asn Thr 
                165                 170                 175     


Ser Lys Thr Ile Leu Ser Ser Glu Leu Ser Ala Gly Val Phe Arg Phe 
            180                 185                 190         


Ile Glu Tyr Gln Arg Leu Leu Glu Leu Glu Ala Gly Tyr Thr Thr Asn 
        195                 200                 205             


Glu Pro Val Met Met Cys Met Met Ser Ala Leu Glu Ala Gly Val Ala 
    210                 215                 220                 


His Leu Ile Val Glu Gly Ile Arg Gln Asn Leu Trp Ser Leu Gln Asn 
225                 230                 235                 240 


Pro Ser Asp Ile Asn Asn Pro Ile Ile Gln Arg Tyr Met Lys Glu Asp 
                245                 250                 255     


Val Pro 
        


<210>  33
<211>  248
<212>  PRT
<213>  Vibrio fischeri

<400>  33

Pro Glu Thr Ser Glu Ser Pro Thr Leu Met Gln Arg Gly Ala Asn Tyr 
1               5                   10                  15      


Ile Asp Leu Ile Ser Leu Pro Lys Pro Gln Gly Lys Ile Phe Val Ser 
            20                  25                  30          


Val Tyr Asp Phe Arg Asp Gln Thr Gly Gln Tyr Lys Pro Gln Pro Asn 
        35                  40                  45              


Ser Asn Phe Ser Thr Ala Val Pro Gln Gly Gly Thr Ala Leu Leu Thr 
    50                  55                  60                  


Met Ala Leu Leu Asp Ser Glu Trp Phe Tyr Pro Leu Glu Arg Gln Gly 
65                  70                  75                  80  


Leu Gln Asn Leu Leu Thr Glu Arg Lys Ile Ile Arg Ala Ala Gln Lys 
                85                  90                  95      


Lys Gln Glu Ser Ile Ser Asn His Gly Ser Thr Leu Pro Ser Leu Leu 
            100                 105                 110         


Ser Ala Asn Val Met Ile Glu Gly Gly Ile Val Ala Tyr Asp Ser Asn 
        115                 120                 125             


Ile Lys Thr Gly Gly Ala Gly Ala Arg Tyr Leu Gly Ile Gly Gly Ser 
    130                 135                 140                 


Gly Gln Tyr Arg Ala Asp Gln Val Thr Val Asn Ile Arg Ala Val Asp 
145                 150                 155                 160 


Val Arg Ser Gly Lys Ile Leu Thr Ser Val Thr Thr Ser Lys Thr Ile 
                165                 170                 175     


Leu Ser Tyr Glu Val Ser Ala Gly Ala Phe Arg Phe Val Asp Tyr Lys 
            180                 185                 190         


Glu Leu Leu Glu Val Glu Leu Gly Tyr Thr Asn Asn Glu Pro Val Asn 
        195                 200                 205             


Ile Ala Leu Met Ser Ala Ile Asp Ser Ala Val Ile His Leu Ile Val 
    210                 215                 220                 


Lys Gly Val Gln Gln Gly Leu Trp Arg Pro Ala Asn Leu Asp Thr Arg 
225                 230                 235                 240 


Asn Asn Pro Ile Phe Lys Lys Tyr 
                245             


<210>  34
<211>  248
<212>  PRT
<213>  Aliivibrio logei

<400>  34

Pro Asp Ala Ser Glu Ser Pro Thr Leu Met Gln Arg Gly Ala Thr Tyr 
1               5                   10                  15      


Leu Asp Leu Ile Ser Leu Pro Lys Pro Gln Gly Lys Ile Tyr Val Ser 
            20                  25                  30          


Val Tyr Asp Phe Arg Asp Gln Thr Gly Gln Tyr Lys Pro Gln Pro Asn 
        35                  40                  45              


Ser Asn Phe Ser Thr Ala Val Pro Gln Gly Gly Thr Ala Leu Leu Thr 
    50                  55                  60                  


Met Ala Leu Leu Asp Ser Glu Trp Phe Tyr Pro Leu Glu Arg Gln Gly 
65                  70                  75                  80  


Leu Gln Asn Leu Leu Thr Glu Arg Lys Ile Ile Arg Ala Ala Gln Lys 
                85                  90                  95      


Lys Gln Glu Ser Ile Ser Asn His Gly Ser Thr Leu Pro Ser Leu Leu 
            100                 105                 110         


Ser Ala Asn Val Met Ile Glu Gly Gly Ile Val Ala Tyr Asp Ser Asn 
        115                 120                 125             


Ile Lys Thr Gly Gly Ala Gly Ala Arg Tyr Leu Gly Ile Gly Gly Ser 
    130                 135                 140                 


Gly Gln Tyr Arg Ala Asp Gln Val Thr Val Asn Ile Arg Ala Val Asp 
145                 150                 155                 160 


Val Arg Ser Gly Lys Ile Leu Thr Ser Val Thr Thr Ser Lys Thr Ile 
                165                 170                 175     


Leu Ser Tyr Glu Leu Ser Ala Gly Ala Phe Arg Phe Val Asp Tyr Lys 
            180                 185                 190         


Glu Leu Leu Glu Val Glu Leu Gly Tyr Thr Asn Asn Glu Pro Val Asn 
        195                 200                 205             


Ile Ala Leu Met Ser Ala Ile Asp Ser Ala Val Ile His Leu Ile Val 
    210                 215                 220                 


Lys Gly Ile Glu Glu Gly Leu Trp Arg Pro Glu Asn Gln Asn Gly Lys 
225                 230                 235                 240 


Glu Asn Pro Ile Phe Arg Lys Tyr 
                245             


<210>  35
<211>  254
<212>  PRT
<213>  Photobacterium sp

<400>  35

Pro Glu Thr Ser Lys Glu Pro Thr Leu Met Ala Arg Gly Thr Ala Tyr 
1               5                   10                  15      


Gln Asp Leu Val Ser Leu Pro Leu Pro Lys Gly Lys Val Tyr Val Ser 
            20                  25                  30          


Val Tyr Asp Phe Arg Asp Gln Thr Gly Gln Tyr Lys Pro Gln Pro Asn 
        35                  40                  45              


Ser Asn Phe Ser Thr Ala Val Pro Gln Gly Gly Ala Ala Leu Leu Thr 
    50                  55                  60                  


Thr Ala Leu Leu Asp Ser Arg Trp Phe Met Pro Leu Glu Arg Glu Gly 
65                  70                  75                  80  


Leu Gln Asn Leu Leu Thr Glu Arg Lys Ile Ile Arg Ala Ala Gln Lys 
                85                  90                  95      


Lys Asp Glu Ile Pro Thr Asn His Gly Val His Leu Pro Ser Leu Ala 
            100                 105                 110         


Ser Ala Asn Ile Met Val Glu Gly Gly Ile Val Ala Tyr Asp Thr Asn 
        115                 120                 125             


Ile Gln Thr Gly Gly Ala Gly Ala Arg Tyr Leu Gly Val Gly Ala Ser 
    130                 135                 140                 


Gly Gln Tyr Arg Thr Asp Gln Val Thr Val Asn Ile Arg Ala Val Asp 
145                 150                 155                 160 


Val Arg Thr Gly Arg Ile Leu Leu Ser Val Thr Thr Ser Lys Thr Ile 
                165                 170                 175     


Leu Ser Lys Glu Leu Gln Thr Gly Val Phe Lys Phe Val Asp Tyr Lys 
            180                 185                 190         


Asp Leu Leu Glu Ala Glu Leu Gly Tyr Thr Thr Asn Glu Pro Val Asn 
        195                 200                 205             


Leu Ala Val Met Ser Ala Ile Asp Ala Ala Val Val His Val Ile Val 
    210                 215                 220                 


Asp Gly Ile Lys Thr Gly Leu Trp Glu Pro Leu Arg Gly Glu Asp Leu 
225                 230                 235                 240 


Gln His Pro Ile Ile Gln Glu Tyr Met Asn Arg Ser Lys Pro 
                245                 250                 


<210>  36
<211>  261
<212>  PRT
<213>  Aeromonas veronii

<400>  36

Cys Ala Thr His Ile Gly Ser Pro Val Ala Asp Glu Lys Ala Thr Leu 
1               5                   10                  15      


Met Pro Arg Ser Val Ser Tyr Lys Glu Leu Ile Ser Leu Pro Lys Pro 
            20                  25                  30          


Lys Gly Lys Ile Val Ala Ala Val Tyr Asp Phe Arg Asp Gln Thr Gly 
        35                  40                  45              


Gln Tyr Leu Pro Ala Pro Ala Ser Asn Phe Ser Thr Ala Val Thr Gln 
    50                  55                  60                  


Gly Gly Val Ala Met Leu Ser Thr Ala Leu Trp Asp Ser Gln Trp Phe 
65                  70                  75                  80  


Val Pro Leu Glu Arg Glu Gly Leu Gln Asn Leu Leu Thr Glu Arg Lys 
                85                  90                  95      


Ile Val Arg Ala Ala Gln Asn Lys Pro Asn Val Pro Gly Asn Asn Ala 
            100                 105                 110         


Asn Gln Leu Pro Ser Leu Val Ala Ala Asn Ile Leu Ile Glu Gly Gly 
        115                 120                 125             


Ile Val Ala Tyr Asp Ser Asn Val Arg Thr Gly Gly Ala Gly Ala Lys 
    130                 135                 140                 


Tyr Phe Gly Ile Gly Ala Ser Gly Glu Tyr Arg Val Asp Gln Val Thr 
145                 150                 155                 160 


Val Asn Leu Arg Ala Val Asp Ile Arg Ser Gly Arg Ile Leu Asn Ser 
                165                 170                 175     


Val Thr Thr Ser Lys Thr Val Met Ser Gln Gln Val Gln Ala Gly Val 
            180                 185                 190         


Phe Arg Phe Val Glu Tyr Lys Arg Leu Leu Glu Ala Glu Ala Gly Phe 
        195                 200                 205             


Ser Thr Asn Glu Pro Val Gln Met Cys Val Met Ser Ala Ile Glu Ser 
    210                 215                 220                 


Gly Val Ile Arg Leu Ile Ala Asn Gly Val Arg Asp Asn Leu Trp Gln 
225                 230                 235                 240 


Leu Ala Asp Gln Arg Asp Ile Asp Asn Pro Ile Leu Gln Glu Tyr Leu 
                245                 250                 255     


Gln Asp Asn Ala Pro 
            260     


<210>  37
<211>  239
<212>  PRT
<213>  Shewanella sp.

<400>  37

Ala Ser Ser Ser Leu Met Pro Lys Gly Glu Ser Tyr Tyr Asp Leu Ile 
1               5                   10                  15      


Asn Leu Pro Ala Pro Gln Gly Val Met Leu Ala Ala Val Tyr Asp Phe 
            20                  25                  30          


Arg Asp Gln Thr Gly Gln Tyr Lys Pro Ile Pro Ser Ser Asn Phe Ser 
        35                  40                  45              


Thr Ala Val Pro Gln Ser Gly Thr Ala Phe Leu Ala Gln Ala Leu Asn 
    50                  55                  60                  


Asp Ser Ser Trp Phe Ile Pro Val Glu Arg Glu Gly Leu Gln Asn Leu 
65                  70                  75                  80  


Leu Thr Glu Arg Lys Ile Val Arg Ala Gly Leu Lys Gly Asp Ala Asn 
                85                  90                  95      


Lys Leu Pro Gln Leu Asn Ser Ala Gln Ile Leu Met Glu Gly Gly Ile 
            100                 105                 110         


Val Ala Tyr Asp Thr Asn Val Arg Thr Gly Gly Ala Gly Ala Arg Tyr 
        115                 120                 125             


Leu Gly Ile Gly Ala Ala Thr Gln Phe Arg Val Asp Thr Val Thr Val 
    130                 135                 140                 


Asn Leu Arg Ala Val Asp Ile Arg Thr Gly Arg Leu Leu Ser Ser Val 
145                 150                 155                 160 


Thr Thr Thr Lys Ser Ile Leu Ser Lys Glu Ile Thr Ala Gly Val Phe 
                165                 170                 175     


Lys Phe Ile Asp Ala Gln Glu Leu Leu Glu Ser Glu Leu Gly Tyr Thr 
            180                 185                 190         


Ser Asn Glu Pro Val Ser Leu Cys Val Ala Ser Ala Ile Glu Ser Ala 
        195                 200                 205             


Val Val His Met Ile Ala Asp Gly Ile Trp Lys Gly Ala Trp Asn Leu 
    210                 215                 220                 


Ala Asp Gln Ala Ser Gly Leu Arg Ser Pro Val Leu Gln Lys Tyr 
225                 230                 235                 


<210>  38
<211>  233
<212>  PRT
<213>  Pseudomonas putida

<400>  38

Gln Asp Ser Glu Thr Pro Thr Leu Thr Pro Arg Ala Ser Thr Tyr Tyr 
1               5                   10                  15      


Asp Leu Ile Asn Met Pro Arg Pro Lys Gly Arg Leu Met Ala Val Val 
            20                  25                  30          


Tyr Gly Phe Arg Asp Gln Thr Gly Gln Tyr Lys Pro Thr Pro Ala Ser 
        35                  40                  45              


Ser Phe Ser Thr Ser Val Thr Gln Gly Ala Ala Ser Met Leu Met Asp 
    50                  55                  60                  


Ala Leu Ser Ala Ser Gly Trp Phe Val Val Leu Glu Arg Glu Gly Leu 
65                  70                  75                  80  


Gln Asn Leu Leu Thr Glu Arg Lys Ile Ile Arg Ala Ser Gln Lys Lys 
                85                  90                  95      


Pro Asp Val Ala Glu Asn Ile Met Gly Glu Leu Pro Pro Leu Gln Ala 
            100                 105                 110         


Ala Asn Leu Met Leu Glu Gly Gly Ile Ile Ala Tyr Asp Thr Asn Val 
        115                 120                 125             


Arg Ser Gly Gly Glu Gly Ala Arg Tyr Leu Gly Ile Asp Ile Ser Arg 
    130                 135                 140                 


Glu Tyr Arg Val Asp Gln Val Thr Val Asn Leu Arg Ala Val Asp Val 
145                 150                 155                 160 


Arg Thr Gly Gln Val Leu Ala Asn Val Met Thr Ser Lys Thr Ile Tyr 
                165                 170                 175     


Ser Val Gly Arg Ser Ala Gly Val Phe Lys Phe Ile Glu Phe Lys Lys 
            180                 185                 190         


Leu Leu Glu Ala Glu Val Gly Tyr Thr Thr Asn Glu Pro Ala Gln Leu 
        195                 200                 205             


Cys Val Leu Ser Ala Ile Glu Ser Ala Val Gly His Leu Leu Ala Gln 
    210                 215                 220                 


Gly Ile Glu Gln Arg Leu Trp Gln Val 
225                 230             


<210>  39
<211>  234
<212>  PRT
<213>  Shewanella violacea

<400>  39

Met Pro Lys Ser Asp Thr Tyr Tyr Asp Leu Ile Gly Leu Pro His Pro 
1               5                   10                  15      


Gln Gly Ser Met Leu Ala Ala Val Tyr Asp Phe Arg Asp Gln Thr Gly 
            20                  25                  30          


Gln Tyr Lys Ala Ile Pro Ser Ser Asn Phe Ser Thr Ala Val Pro Gln 
        35                  40                  45              


Ser Gly Thr Ala Phe Leu Ala Gln Ala Leu Asn Asp Ser Ser Trp Phe 
    50                  55                  60                  


Val Pro Val Glu Arg Glu Gly Leu Gln Asn Leu Leu Thr Glu Arg Lys 
65                  70                  75                  80  


Ile Val Arg Ala Gly Leu Lys Gly Glu Ala Asn Gln Leu Pro Gln Leu 
                85                  90                  95      


Ser Ser Ala Gln Ile Leu Met Glu Gly Gly Ile Val Ala Tyr Asp Thr 
            100                 105                 110         


Asn Ile Lys Thr Gly Gly Ala Gly Ala Arg Tyr Leu Gly Ile Gly Val 
        115                 120                 125             


Asn Ser Lys Phe Arg Val Asp Thr Val Thr Val Asn Leu Arg Ala Val 
    130                 135                 140                 


Asp Ile Arg Thr Gly Arg Leu Leu Ser Ser Val Thr Thr Thr Lys Ser 
145                 150                 155                 160 


Ile Leu Ser Lys Glu Val Ser Ala Gly Val Phe Lys Phe Ile Asp Ala 
                165                 170                 175     


Gln Asp Leu Leu Glu Ser Glu Leu Gly Tyr Thr Ser Asn Glu Pro Val 
            180                 185                 190         


Ser Leu Cys Val Ala Gln Ala Ile Glu Ser Ala Val Val His Met Ile 
        195                 200                 205             


Ala Asp Gly Ile Trp Lys Arg Ala Trp Asn Leu Ala Asp Thr Ala Ser 
    210                 215                 220                 


Gly Leu Asn Asn Pro Val Leu Gln Lys Tyr 
225                 230                 


<210>  40
<211>  245
<212>  PRT
<213>  Marinobacterium jannaschii

<400>  40

Leu Thr Arg Arg Met Ser Thr Tyr Gln Asp Leu Ile Asp Met Pro Ala 
1               5                   10                  15      


Pro Arg Gly Lys Ile Val Thr Ala Val Tyr Ser Phe Arg Asp Gln Ser 
            20                  25                  30          


Gly Gln Tyr Lys Pro Ala Pro Ser Ser Ser Phe Ser Thr Ala Val Thr 
        35                  40                  45              


Gln Gly Ala Ala Ala Met Leu Val Asn Val Leu Asn Asp Ser Gly Trp 
    50                  55                  60                  


Phe Ile Pro Leu Glu Arg Glu Gly Leu Gln Asn Ile Leu Thr Glu Arg 
65                  70                  75                  80  


Lys Ile Ile Arg Ala Ala Leu Lys Lys Asp Asn Val Pro Val Asn Asn 
                85                  90                  95      


Ser Ala Gly Leu Pro Ser Leu Leu Ala Ala Asn Ile Met Leu Glu Gly 
            100                 105                 110         


Gly Ile Val Gly Tyr Asp Ser Asn Ile His Thr Gly Gly Ala Gly Ala 
        115                 120                 125             


Arg Tyr Phe Gly Ile Gly Ala Ser Glu Lys Tyr Arg Val Asp Glu Val 
    130                 135                 140                 


Thr Val Asn Leu Arg Ala Ile Asp Ile Arg Thr Gly Arg Ile Leu His 
145                 150                 155                 160 


Ser Val Leu Thr Ser Lys Lys Ile Leu Ser Arg Glu Ile Arg Ser Asp 
                165                 170                 175     


Val Tyr Arg Phe Ile Glu Phe Lys His Leu Leu Glu Met Glu Ala Gly 
            180                 185                 190         


Ile Thr Thr Asn Asp Pro Ala Gln Leu Cys Val Leu Ser Ala Ile Glu 
        195                 200                 205             


Ser Ala Val Ala His Leu Ile Val Asp Gly Val Ile Lys Lys Ser Trp 
    210                 215                 220                 


Ser Leu Ala Asp Pro Asn Glu Leu Asn Ser Pro Val Ile Gln Ala Tyr 
225                 230                 235                 240 


Gln Gln Gln Arg Ile 
                245 


<210>  41
<211>  234
<212>  PRT
<213>  Chryseobacterium oranimense

<400>  41

Pro Ser Asp Pro Glu Arg Ser Thr Met Gly Glu Leu Thr Pro Ser Thr 
1               5                   10                  15      


Ala Glu Leu Arg Asn Leu Pro Leu Pro Asn Glu Lys Ile Val Ile Gly 
            20                  25                  30          


Val Tyr Lys Phe Arg Asp Gln Thr Gly Gln Tyr Lys Pro Ser Glu Asn 
        35                  40                  45              


Gly Asn Asn Trp Ser Thr Ala Val Pro Gln Gly Thr Thr Thr Ile Leu 
    50                  55                  60                  


Ile Lys Ala Leu Glu Asp Ser Arg Trp Phe Ile Pro Ile Glu Arg Glu 
65                  70                  75                  80  


Asn Ile Ala Asn Leu Leu Asn Glu Arg Gln Ile Ile Arg Ser Thr Arg 
                85                  90                  95      


Gln Glu Tyr Met Lys Asp Ala Asp Lys Asn Ser Gln Ser Leu Pro Pro 
            100                 105                 110         


Leu Leu Tyr Ala Gly Ile Leu Leu Glu Gly Gly Val Ile Ser Tyr Asp 
        115                 120                 125             


Ser Asn Thr Met Thr Gly Gly Phe Gly Ala Arg Tyr Phe Gly Ile Gly 
    130                 135                 140                 


Ala Ser Thr Gln Tyr Arg Gln Asp Arg Ile Thr Ile Tyr Leu Arg Ala 
145                 150                 155                 160 


Val Ser Thr Leu Asn Gly Glu Ile Leu Lys Thr Val Tyr Thr Ser Lys 
                165                 170                 175     


Thr Ile Leu Ser Thr Ser Val Asn Gly Ser Phe Phe Arg Tyr Ile Asp 
            180                 185                 190         


Thr Glu Arg Leu Leu Glu Ala Glu Val Gly Leu Thr Gln Asn Glu Pro 
        195                 200                 205             


Val Gln Leu Ala Val Thr Glu Ala Ile Glu Lys Ala Val Arg Ser Leu 
    210                 215                 220                 


Ile Ile Glu Gly Thr Arg Asp Lys Ile Trp 
225                 230                 


<210>  42
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example 2

<400>  42
tttttttttt tt                                                           12


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example 2

<400>  43
ggttgtttct gttggtgctg atattgc                                           27


<210>  44
<211>  3635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example 2

<400>  44
gccatcagat tgtgtttgtt agtcgctgcc atcagattgt gtttgttagt cgcttttttt       60

ttttggaatt ttttttttgg aatttttttt ttgcgctaac aacctcctgc cgttttgccc      120

gtgcatatcg gtcacgaaca aatctgatta ctaaacacag tagcctggat ttgttctatc      180

agtaatcgac cttattccta attaaataga gcaaatcccc ttattggggg taagacatga      240

agatgccaga aaaacatgac ctgttggccg ccattctcgc ggcaaaggaa caaggcatcg      300

gggcaatcct tgcgtttgca atggcgtacc ttcgcggcag atataatggc ggtgcgttta      360

caaaaacagt aatcgacgca acgatgtgcg ccattatcgc ctagttcatt cgtgaccttc      420

tcgacttcgc cggactaagt agcaatctcg cttatataac gagcgtgttt atcggctaca      480

tcggtactga ctcgattggt tcgcttatca aacgcttcgc tgctaaaaaa gccggagtag      540

aagatggtag aaatcaataa tcaacgtaag gcgttcctcg atatgctggc gtggtcggag      600

ggaactgata acggacgtca gaaaaccaga aatcatggtt atgacgtcat tgtaggcgga      660

gagctattta ctgattactc cgatcaccct cgcaaacttg tcacgctaaa cccaaaactc      720

aaatcaacag gcgccggacg ctaccagctt ctttcccgtt ggtgggatgc ctaccgcaag      780

cagcttggcc tgaaagactt ctctccgaaa agtcaggacg ctgtggcatt gcagcagatt      840

aaggagcgtg gcgctttacc tatgattgat cgtggtgata tccgtcaggc aatcgaccgt      900

tgcagcaata tctgggcttc actgccgggc gctggttatg gtcagttcga gcataaggct      960

gacagcctga ttgcaaaatt caaagaagcg ggcggaacgg tcagagagat tgatgtatga     1020

gcagagtcac cgcgattatc tccgctctgg ttatctgcat catcgtctgc ctgtcatggg     1080

ctgttaatca ttaccgtgat aacgccatta cctacaaagc ccagcgcgac aaaaatgcca     1140

gagaactgaa gctggcgaac gcggcaatta ctgacatgca gatgcgtcag cgtgatgttg     1200

ctgcgctcga tgcaaaatac acgaaggagt tagctgatgc taaagctgaa aatgatgctc     1260

tgcgtgatga tgttgccgct ggtcgtcgtc ggttgcacat caaagcagtc tgtcagtcag     1320

tgcgtgaagc caccaccgcc tccggcgtgg ataatgcagc ctccccccga ctggcagaca     1380

ccgctgaacg ggattatttc accctcagag agaggctgat cactatgcaa aaacaactgg     1440

aaggaaccca gaagtatatt aatgagcagt gcagatagag ttgcccatat cgatgggcaa     1500

ctcatgcaat tattgtgagc aatacacacg cgcttccagc ggagtataaa tgcctaaagt     1560

aataaaaccg agcaatccat ttacgaatgt ttgctgggtt tctgttttaa caacattttc     1620

tgcgccgcca caaattttgg ctgcatcgac agttttcttc tgcccaattc cagaaacgaa     1680

gaaatgatgg gtgatggttt cctttggtgc tactgctgcc ggtttgtttt gaacagtaaa     1740

cgtctgttga gcacatcctg taataagcag ggccagcgca gtagcgagta gcattttttt     1800

catggtgtta ttcccgatgc tttttgaagt tcgcagaatc gtatgtgtag aaaattaaac     1860

aaaccctaaa caatgagttg aaatttcata ttgttaatat ttattaatgt atgtcaggtg     1920

cgatgaatcg tcattgtatt cccggattaa ctatgtccac agccctgacg gggaacttct     1980

ctgcgggagt gtccgggaat aattaaaacg atgcacacag ggtttagcgc gtacacgtat     2040

tgcattatgc caacgccccg gtgctgacac ggaagaaacc ggacgttatg atttagcgtg     2100

gaaagatttg tgtagtgttc tgaatgctct cagtaaatag taatgaatta tcaaaggtat     2160

agtaatatct tttatgttca tggatatttg taacccatcg gaaaactcct gctttagcaa     2220

gattttccct gtattgctga aatgtgattt ctcttgattt caacctatca taggacgttt     2280

ctataagatg cgtgtttctt gagaatttaa catttacaac ctttttaagt ccttttatta     2340

acacggtgtt atcgttttct aacacgatgt gaatattatc tgtggctaga tagtaaatat     2400

aatgtgagac gttgtgacgt tttagttcag aataaaacaa ttcacagtct aaatcttttc     2460

gcacttgatc gaatatttct ttaaaaatgg caacctgagc cattggtaaa accttccatg     2520

tgatacgagg gcgcgtagtt tgcattatcg tttttatcgt ttcaatctgg tctgacctcc     2580

ttgtgttttg ttgatgattt atgtcaaata ttaggaatgt tttcacttaa tagtattggt     2640

tgcgtaacaa agtgcggtcc tgctggcatt ctggagggaa atacaaccga cagatgtatg     2700

taaggccaac gtgctcaaat cttcatacag aaagatttga agtaatattt taaccgctag     2760

atgaagagca agcgcatgga gcgacaaaat gaataaagaa caatctgctg atgatccctc     2820

cgtggatctg attcgtgtaa aaaatatgct taatagcacc atttctatga gttaccctga     2880

tgttgtaatt gcatgtatag aacataaggt gtctctggaa gcattcagag caattgaggc     2940

agcgttggtg aagcacgata ataatatgaa ggattattcc ctggtggttg actgatcacc     3000

ataactgcta atcattcaaa ctatttagtc tgtgacagag ccaacacgca gtctgtcact     3060

gtcaggaaag tggtaaaact gcaactcaat tactgcaatg ccctcgtaat taagtgaatt     3120

tacaatatcg tcctgttcgg agggaagaac gcgggatgtt cattcttcat cacttttaat     3180

tgatgtatat gctctctttt ctgacgttag tctccgacgg caggcttcaa tgacccaggc     3240

tgagaaattc ccggaccctt tttgctcaag agcgatgtta atttgttcaa tcatttggtt     3300

aggaaagcgg atgttgcggg ttgttgttct gcgggttctg ttcttcgttg acatgaggtt     3360

gccccgtatt cagtgtcgct gatttgtatt gtctgaagtt gtttttacgt taagttgatg     3420

cagatcaatt aatacgatac ctgcgtcata attgattatt tgacgtggtt tgatggcctc     3480

cacgcacgtt gtgatatgta gatgataatc attatcactt tacgggtcct ttccggtgaa     3540

aaaaaaggta ccaaaaaaaa catcgtcgtg agtagtgaac cgtaagccgt tctgtttatg     3600

tttcttggac actgattgac acggtttagt agaac                                3635


<210>  45
<211>  3636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example 2

<400>  45
tttttttttt tttttttttt ttttttttca agaaacataa acagaacgtg cttacggttc       60

actactcacg acgatgtttt ttttggtacc ttttttttca ccggaaagga cccgtaaagt      120

gataatgatt atcatctaca tatcacaacg tgcgtggagg ccatcaaacc acgtcaaata      180

atcaattatg acgcaggtat cgtattaatt gatctgcatc aacttaacgt aaaaacaact      240

tcagacaata caaatcagcg acactgaata cggggcaacc tcatgtcaac gaagaacaga      300

acccgcagaa caacaacccg caacatccgc tttcctaacc aaatgattga acaaattaac      360

atcgctcttg agcaaaaagg gtccgggaat ttctcagcct gggtcattga agcctgccgt      420

cggagactaa cgtcagaaaa gagagcatat acatcaatta aaagtgatga agaatgaaca      480

tcccgcgttc ttccctccga acaggacgat attgtaaatt cacttaatta cgagggcatt      540

gcagtaattg agttgcagtt ttaccacttt cctgacagtg acagactgcg tgttggctct      600

gtcacagact aaatagtttg aatgattagc agttatggtg atcagtcaac caccagggaa      660

taatccttca tattattatc gtgcttcacc aacgctgcct caattgctct gaatgcttcc      720

agagacacct tatgttctat acatgcaatt acaacatcag ggtaactcat agaaatggtg      780

ctattaagca tattttttac acgaatcaga tccacggagg gatcatcagc agattgttct      840

ttattcattt tgtcgctcca tgcgcttgct cttcatctag cggttaaaat attacttcaa      900

atctttctgt atgaagattt gagcacgttg gccttacata catctgtcgg ttgtatttcc      960

ctccagaatg ccagcaggac cgcactttgt tacgcaacca atactattaa gtgaaaacat     1020

tcctaatatt tgacataaat catcaacaaa acacaaggag gtcagaccag attgaaacga     1080

taaaaacgat aatgcaaact acgcgccctc gtatcacatg gaaggtttta ccaatggctc     1140

aggttgccat ttttaaagaa atattcgatc aagtgcgaaa agatttagac tgtgaattgt     1200

tttattctga actaaaacgt cacaacgtct cacattatat ttactatcta gccacagata     1260

atattcacat cgtgttagaa aacgataaca ccgtgttaat aaaaggactt aaaaaggttg     1320

taaatgttaa attctcaaga aacacgcatc ttatagaaac gtcctatgat aggttgaaat     1380

caagagaaat cacatttcag caatacaggg aaaatcttgc taaagcagga gttttccgat     1440

gggttacaaa tatccatgaa cataaaagat attactatac ctttgataat tcattactat     1500

ttactgagag cattcagaac actacacaaa tctttccacg ctaaatcata acgtccggtt     1560

tcttccgtgt cagcaccggg gcgttggcat aatgcaatac gtgtacgcgc taaaccctgt     1620

gtgcatcgtt ttaattattc ccggacactc ccgcagagaa gttccccgtc agggctgtgg     1680

acatagttaa tccgggaata caatgacgat tcatcgcacc tgacatacat taataaatat     1740

taacaatatg aaatttcaac tcattgttta gggtttgttt aattttctac acatacgatt     1800

ctgcgaactt caaaaagcat cgggaataac accatgaaaa aaatgctact cgctactgcg     1860

ctggccctgc ttattacagg atgtgctcaa cagacgttta ctgttcaaaa caaaccggca     1920

gcagtagcac caaaggaaac catcacccat catttcttcg tttctggaat tgggcagaag     1980

aaaactgtcg atgcagccaa aatttgtggc ggcgcagaaa atgttgttaa aacagaaacc     2040

cagcaaacat tcgtaaatgg attgctcggt tttattactt taggcattta tactccgctg     2100

gaagcgcgtg tgtattgctc acaataattg catgagttgc ccatcgatat gggcaactct     2160

atctgcactg ctcattaata tacttctggg ttccttccag ttgtttttgc atagtgatca     2220

gcctctctct gagggtgaaa taatcccgtt cagcggtgtc tgccagtcgg ggggaggctg     2280

cattatccac gccggaggcg gtggtggctt cacgcactga ctgacagact gctttgatgt     2340

gcaaccgacg acgaccagcg gcaacatcat cacgcagagc atcattttca gctttagcat     2400

cagctaactc cttcgtgtat tttgcatcga gcgcagcaac atcacgctga cgcatctgca     2460

tgtcagtaat tgccgcgttc gccagcttca gttctctggc atttttgtcg cgctgggctt     2520

tgtaggtaat ggcgttatca cggtaatgat taacagccca tgacaggcag acgatgatgc     2580

agataaccag agcggagata atcgcggtga ctctgctcat acatcaatct ctctgaccgt     2640

tccgcccgct tctttgaatt ttgcaatcag gctgtcagcc ttatgctcga actgaccata     2700

accagcgccc ggcagtgaag cccagatatt gctgcaacgg tcgattgcct gacggatatc     2760

accacgatca atcataggta aagcgccacg ctccttaatc tgctgcaatg ccacagcgtc     2820

ctgacttttc ggagagaagt ctttcaggcc aagctgcttg cggtaggcat cccaccaacg     2880

ggaaagaagc tggtagcgtc cggcgcctgt tgatttgagt tttgggttta gcgtgacaag     2940

tttgcgaggg tgatcggagt aatcagtaaa tagctctccg cctacaatga cgtcataacc     3000

atgatttctg gttttctgac gtccgttatc agttccctcc gaccacgcca gcatatcgag     3060

gaacgcctta cgttgattat tgatttctac catcttctac tccggctttt ttagcagcga     3120

agcgtttgat aagcgaacca atcgagtcag taccgatgta gccgataaac acgctcgtta     3180

tataagcgag attgctactt agtccggcga agtcgagaag gtcacgaatg aactaggcga     3240

taatggcgca catcgttgcg tcgattactg tttttgtaaa cgcaccgcca ttatatctgc     3300

cgcgaaggta cgccattgca aacgcaagga ttgccccgat gccttgttcc tttgccgcga     3360

gaatggcggc caacaggtca tgtttttctg gcatcttcat gtcttacccc caataagggg     3420

atttgctcta tttaattagg aataaggtcg attactgata gaacaaatcc aggctactgt     3480

gtttagtaat cagatttgtt cgtgaccgat atgcacgggc aaaacggcag gaggttgtta     3540

gcgcaaaaaa aaaattccaa aaaaaaaatt ccaaaaaaaa aaagcgacta acaaacacaa     3600

tctgatggca gcgactaaca aacacaatct gatggc                               3636


<210>  46
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example 2

<400>  46
gcaatatcag caccaacaga aacaacct                                          28


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  StrepII (C)

<400>  47

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pro

<400>  48

Met Gln Arg Leu Phe Leu Leu Val Ala Val Met Leu Leu Ser Gly 
1               5                   10                  15  


<210>  49
<211>  558
<212>  DNA
<213>  Mycobacterium smegmatis

<400>  49
atgggcctgg ataacgaact tagcctggtg gacggccaag atcgcacgct gacggtgcaa       60

caatgggata ccttcctgaa tggtgtgttt ccgctggatc gtaaccgcct gacccgtgaa      120

tggtttcatt ccggtcgcgc aaaatatatc gtcgcaggcc cgggtgctga cgaattcgaa      180

ggcacgctgg aactgggtta tcagattggc tttccgtggt cactgggcgt tggtatcaac      240

ttctcgtaca ccacgccgaa tattctgatc gatgacggtg atattaccgc accgccgttt      300

ggcctgaaca gcgtgattac gccgaacctg tttccgggtg ttagcatctc tgccgatctg      360

ggcaacggtc cgggcattca agaagtggca acctttagtg tggacgtttc cggcgctgaa      420

ggcggtgtcg cggtgtctaa tgcccacggt accgttacgg gcgcggccgg cggtgtcctg      480

ctgcgtccgt tcgcgcgcct gattgcgagc accggcgact ctgttacgac ctatggcgaa      540

ccgtggaata tgaactaa                                                    558


<210>  50
<211>  184
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  50

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Ala 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Ala Glu Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  51
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Thrombin Binding Aptamer

<400>  51
tttttttttt tttttttttt ggttggtgtg gttgg                                  35


<210>  52
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y Adaptor Top Strand


<220>
<221>  C3 Spacer
<222>  (1)..(30)
<223>  C3 Spacer phosphoramidite (Integrated DNA technologies: 5SpC3)

<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (64)..(67)
<223>  n is a, c, g, or t

<220>
<221>  18 Spacer
<222>  (80)..(83)
<223>  18-atom hexa-ethyleneglycol spacer (Integrated DNA technologies: 
       iSp18)

<400>  52
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ggcgtctgct tgggtgttta accttttttt       60

tttnnnnaat gtacttcgtt cagttacgta ttgct                                  95


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y Adaptor Blocker Strand

<400>  53
ttccgcagac gaacccacaa attgg                                             25


<210>  54
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y Adaptor Cholesterol Tether


<220>
<221>  5' Cholesterol tag
<222>  (1)..(1)

<400>  54
ttgaccgctc gcctc                                                        15


<210>  55
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y Adaptor Bottom Strand


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  5 Phos

<400>  55
aactggcgag cggagttttt acatgaagca agtcaatgca taacg                       45


<210>  56
<211>  3561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3.6kb target sequence

<400>  56
gccatcagat tgtgtttgtt agtcgctttt tttttttgga attttttttt tggaattttt       60

tttttgcgct aacaacctcc tgccgttttg cccgtgcata tcggtcacga acaaatctga      120

ttactaaaca cagtagcctg gatttgttct atcagtaatc gaccttattc ctaattaaat      180

agagcaaatc cccttattgg gggtaagaca tgaagatgcc agaaaaacat gacctgttgg      240

ccgccattct cgcggcaaag gaacaaggca tcggggcaat ccttgcgttt gcaatggcgt      300

accttcgcgg cagatataat ggcggtgcgt ttacaaaaac agtaatcgac gcaacgatgt      360

gcgccattat cgcctagttc attcgtgacc ttctcgactt cgccggacta agtagcaatc      420

tcgcttatat aacgagcgtg tttatcggct acatcggtac tgactcgatt ggttcgctta      480

tcaaacgctt cgctgctaaa aaagccggag tagaagatgg tagaaatcaa taatcaacgt      540

aaggcgttcc tcgatatgct ggcgtggtcg gagggaactg ataacggacg tcagaaaacc      600

agaaatcatg gttatgacgt cattgtaggc ggagagctat ttactgatta ctccgatcac      660

cctcgcaaac ttgtcacgct aaacccaaaa ctcaaatcaa caggcgccgg acgctaccag      720

cttctttccc gttggtggga tgcctaccgc aagcagcttg gcctgaaaga cttctctccg      780

aaaagtcagg acgctgtggc attgcagcag attaaggagc gtggcgcttt acctatgatt      840

gatcgtggtg atatccgtca ggcaatcgac cgttgcagca atatctgggc ttcactgccg      900

ggcgctggtt atggtcagtt cgagcataag gctgacagcc tgattgcaaa attcaaagaa      960

gcgggcggaa cggtcagaga gattgatgta tgagcagagt caccgcgatt atctccgctc     1020

tggttatctg catcatcgtc tgcctgtcat gggctgttaa tcattaccgt gataacgcca     1080

ttacctacaa agcccagcgc gacaaaaatg ccagagaact gaagctggcg aacgcggcaa     1140

ttactgacat gcagatgcgt cagcgtgatg ttgctgcgct cgatgcaaaa tacacgaagg     1200

agttagctga tgctaaagct gaaaatgatg ctctgcgtga tgatgttgcc gctggtcgtc     1260

gtcggttgca catcaaagca gtctgtcagt cagtgcgtga agccaccacc gcctccggcg     1320

tggataatgc agcctccccc cgactggcag acaccgctga acgggattat ttcaccctca     1380

gagagaggct gatcactatg caaaaacaac tggaaggaac ccagaagtat attaatgagc     1440

agtgcagata gagttgccca tatcgatggg caactcatgc aattattgtg agcaatacac     1500

acgcgcttcc agcggagtat aaatgcctaa agtaataaaa ccgagcaatc catttacgaa     1560

tgtttgctgg gtttctgttt taacaacatt ttctgcgccg ccacaaattt tggctgcatc     1620

gacagttttc ttctgcccaa ttccagaaac gaagaaatga tgggtgatgg tttcctttgg     1680

tgctactgct gccggtttgt tttgaacagt aaacgtctgt tgagcacatc ctgtaataag     1740

cagggccagc gcagtagcga gtagcatttt tttcatggtg ttattcccga tgctttttga     1800

agttcgcaga atcgtatgtg tagaaaatta aacaaaccct aaacaatgag ttgaaatttc     1860

atattgttaa tatttattaa tgtatgtcag gtgcgatgaa tcgtcattgt attcccggat     1920

taactatgtc cacagccctg acggggaact tctctgcggg agtgtccggg aataattaaa     1980

acgatgcaca cagggtttag cgcgtacacg tattgcatta tgccaacgcc ccggtgctga     2040

cacggaagaa accggacgtt atgatttagc gtggaaagat ttgtgtagtg ttctgaatgc     2100

tctcagtaaa tagtaatgaa ttatcaaagg tatagtaata tcttttatgt tcatggatat     2160

ttgtaaccca tcggaaaact cctgctttag caagattttc cctgtattgc tgaaatgtga     2220

tttctcttga tttcaaccta tcataggacg tttctataag atgcgtgttt cttgagaatt     2280

taacatttac aaccttttta agtcctttta ttaacacggt gttatcgttt tctaacacga     2340

tgtgaatatt atctgtggct agatagtaaa tataatgtga gacgttgtga cgttttagtt     2400

cagaataaaa caattcacag tctaaatctt ttcgcacttg atcgaatatt tctttaaaaa     2460

tggcaacctg agccattggt aaaaccttcc atgtgatacg agggcgcgta gtttgcatta     2520

tcgtttttat cgtttcaatc tggtctgacc tccttgtgtt ttgttgatga tttatgtcaa     2580

atattaggaa tgttttcact taatagtatt ggttgcgtaa caaagtgcgg tcctgctggc     2640

attctggagg gaaatacaac cgacagatgt atgtaaggcc aacgtgctca aatcttcata     2700

cagaaagatt tgaagtaata ttttaaccgc tagatgaaga gcaagcgcat ggagcgacaa     2760

aatgaataaa gaacaatctg ctgatgatcc ctccgtggat ctgattcgtg taaaaaatat     2820

gcttaatagc accatttcta tgagttaccc tgatgttgta attgcatgta tagaacataa     2880

ggtgtctctg gaagcattca gagcaattga ggcagcgttg gtgaagcacg ataataatat     2940

gaaggattat tccctggtgg ttgactgatc accataactg ctaatcattc aaactattta     3000

gtctgtgaca gagccaacac gcagtctgtc actgtcagga aagtggtaaa actgcaactc     3060

aattactgca atgccctcgt aattaagtga atttacaata tcgtcctgtt cggagggaag     3120

aacgcgggat gttcattctt catcactttt aattgatgta tatgctctct tttctgacgt     3180

tagtctccga cggcaggctt caatgaccca ggctgagaaa ttcccggacc ctttttgctc     3240

aagagcgatg ttaatttgtt caatcatttg gttaggaaag cggatgttgc gggttgttgt     3300

tctgcgggtt ctgttcttcg ttgacatgag gttgccccgt attcagtgtc gctgatttgt     3360

attgtctgaa gttgttttta cgttaagttg atgcagatca attaatacga tacctgcgtc     3420

ataattgatt atttgacgtg gtttgatggc ctccacgcac gttgtgatat gtagatgata     3480

atcattatca ctttacgggt cctttccggt gaaaaaaaag gtaccaaaaa aaacatcgtc     3540

gtgagtagtg aaccgtaagc a                                               3561


