                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Anti-LAG-3 Antibodies

<130>  RIC/FP7253115

<150>  SG10201601719R
<151>  2016-03-04

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody A6 
       clone

<400>  1

Asp Val Val Met Thr Gln Ser Pro Leu Pro Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody 1G11
       clone

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Pro Ser Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody C2 
       clone

<400>  3

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody C12 
       clone

<400>  4

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Tyr Asn Tyr Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ala Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody F5 
       clone

<400>  5

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Arg 
                85                  90                  95      


Pro Gly Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105                 110 


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain sequence for Anti-LAG-3 antibody G8 
       clone

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Thr Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain sequence for Anti-LAG-3 antibody A6 
       clone

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Pro Phe Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain sequence for Anti-LAG-3 antibody 1G11
       clone

<400>  8

Gln Leu Gln Leu Gln Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Gly Trp Gly Ala Tyr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain sequence for Anti-LAG-3 antibody C2 
       and G8 clone

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Asp Ala Ala Asn Trp Gly Phe Leu Leu Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  10
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain sequence for Anti-LAG-3 antibody C12 
       clone

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Ala Asp Phe Trp Ser Gly Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain sequence for Anti-LAG-3 antibody F5 
       clone

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Trp Phe Gly Glu Leu Tyr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone LC-CDR1

<400>  12

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone LC-CDR2

<400>  13

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone LC-CDR3

<400>  14

Met Gln Ala Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11 clone LC-CDR1

<400>  15

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11, C2 and G8 clone LC-CDR2

<400>  16

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11 clone LC-CDR3

<400>  17

Gln Gln Tyr Gly Pro Ser Ile Thr 
1               5               


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 clone LC-CDR1

<400>  18

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 clone LC-CDR3

<400>  19

Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone LC-CDR1

<400>  20

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Tyr Asn Tyr Phe Asp 
1               5                   10                  15      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone LC-CDR2

<400>  21

Leu Gly Ser Asn Arg Ala Ala 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone LC-CDR3

<400>  22

Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone LC-CDR1

<400>  23

Arg Ala Ser Gln Ser Val Ser Ser Gly Tyr Leu Ala 
1               5                   10          


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone LC-CDR2

<400>  24

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone LC-CDR3

<400>  25

Gln Gln Tyr Gly Ser Ser Arg Pro Gly Leu Thr 
1               5                   10      


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 clone LC-CDR1

<400>  26

Thr Thr Ser Gln Ser Val Ser Ser Thr Ser Leu Asp 
1               5                   10          


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 clone LC-CDR3

<400>  27

Gln Gln Tyr Gly Ser Ser Leu Leu Thr 
1               5                   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone HC-CDR1

<400>  28

Ser Tyr Tyr Met His 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone HC-CDR2

<400>  29

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6 clone HC-CDR3

<400>  30

Pro Phe Gly Asp Phe Asp Tyr 
1               5           


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11 clone HC-CDR1

<400>  31

Ser Tyr Gly Met His 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11, C2 and G8 clones HC-CDR2

<400>  32

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G11 HC-CDR3

<400>  33

Leu Pro Gly Trp Gly Ala Tyr Ala Phe Asp Ile 
1               5                   10      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 and G8 clones HC-CDR1

<400>  34

Ser Tyr Ala Met His 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 and G8 clones HC-CDR3

<400>  35

Asp Pro Asp Ala Ala Asn Trp Gly Phe Leu Leu Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone HC-CDR1

<400>  36

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone HC-CDR2

<400>  37

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 clone HC-CDR3

<400>  38

Ala Leu Ala Asp Phe Trp Ser Gly Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone HC-CDR1

<400>  39

Glu Leu Ser Met His 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone HC-CDR2

<400>  40

Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 clone HC-CDR3

<400>  41

Thr Trp Phe Gly Glu Leu Tyr Tyr 
1               5               


<210>  42
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A6 clone nucleotide light chain variable domain

<400>  42
gatgttgtga tgactcagtc tccactcccc ctgcccgtca ctcctggaga gccggcctcc       60

atcacctgca ggtccagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaaccccc      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  43
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1G11 clone nucleotide light chain variable domain

<400>  43
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacg       60

ctctcctgca gggccagtca gagcgttagc agcagcttct tggcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggtc cctcaatcac tttcggcgga      300

gggaccaagg tagagatcaa a                                                321


<210>  44
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 clone nucleotide light chain variable domain

<400>  44
gaaattgtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc gatcaccttc      300

ggccaaggga cacgactgga gattaaa                                          327


<210>  45
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C12 clone nucleotide light chain variable domain

<400>  45
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtgatg gatacaacta tttcgattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

gccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

cccacttttg gccaggggac caagctggag atcaaa                                336


<210>  46
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F5 clone nucleotide light chain variable domain

<400>  46
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcggctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gatgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctggggca gacttcactc tcaccatcag cagactacag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtatggta gttcacgtcc agggctcact      300

ttcggcggag ggaccagggt ggagatcaaa                                       330


<210>  47
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G8 clone nucleotide light chain variable domain

<400>  47
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca cgaccagtca gagtgttagc agcacctcct tagactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcta gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacttct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  48
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A6 clone nucleotide heavy chain variable domain

<400>  48
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gatgccattc      300

ggagactttg actactgggg ccagggaacc ctggtcaccg tctcaagc                   348


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1G11 clone nucleotide heavy chain variable domain

<400>  49
cagctgcagc tgcaggagtc ggggggagac gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaggctaccg      300

ggctggggcg cttatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcaagc      360


<210>  50
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 and G8 clones nucleotide heavy chain variable domain

<400>  50
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatccc      300

gacgcggcta actggggatt cttgttgtac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcaagc                                                    378


<210>  51
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C12 clone nucleotide heavy chain variable domain

<400>  51
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagctctg      300

gccgattttt ggagtggtta ctactactac tactacatgg acgtctgggg caaagggacc      360

acggtcaccg tctcaagc                                                    378


<210>  52
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F5 clone nucleotode heavy chain variable domain

<400>  52
gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacagact      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aaccacatgg      300

ttcggggagt tatattactg gggccagggc accctggtca ccgtctcaag c               351


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is R or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is S, A or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is L or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is H or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is S, G or T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is N, F, Y, D or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is G or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Y, A or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is absent or N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is absent or Y

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is absent, Lor F

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is absent or D

<400>  53

Xaa Xaa Ser Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L, G or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is G or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is N or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S, T or A

<400>  54

Xaa Xaa Ser Xaa Arg Ala Xaa 
1               5           


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is M or Q

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is A, Y or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is L, G or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Q, P, S or H

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is T, S or W

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is P, I, R or L

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Y, T, P or L

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is absent, T, I or G

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is absent, T or L

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is absent or T

<400>  55

Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is S or E

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Y or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Y, G, A or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is M or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is H or S

<400>  56

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is I, G or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is I or F

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is N, S, I or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is P or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is S, D, I or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is G, F or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is G or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is S, N, T or E

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is T, K or A

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is S, Y, N or I

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Q or D

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is K or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is F or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Q or K

<400>  57

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Gly 
    


