                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
 
<120>  Human neutralizing antibodies binding to influenza B 
       neuraminidase

<130>  0268 EP P00 PRI

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 HCDR1

<400>  1

Gly Phe Ser Phe Thr Thr Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 HCDR2

<400>  2

Ile Ser Asp Asp Ala Thr Lys Lys 
1               5               


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 HCDR3

<400>  3

Ala Lys Asp Gly Asp Pro Gly Tyr Asp Ser Arg Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 HCDR1

<400>  4

Gly Phe Ser Phe Ser Thr Tyr Gly 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 HCDR2

<400>  5

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 HCDR3

<400>  6

Gly Arg Asp Ser Gly Tyr Thr Thr Asn Trp Tyr Pro Gly Gly Tyr 
1               5                   10                  15  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 HCDR1

<400>  7

Gly Phe Thr Phe Asn Thr His Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 HCDR2

<400>  8

Ile Ser Tyr Asp Gly Asn Ile Lys 
1               5               


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 HCDR3

<400>  9

Ala Arg Asp Arg Gly Asp Tyr Asn Tyr Leu Pro Ser Asp Tyr 
1               5                   10                  


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 LCDR1

<400>  10

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 LCDR2

<400>  11

Tyr Asp Ser 
1           


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-011 LCDR3

<400>  12

Gln Val Trp Asp Ser Ser Ser Asp His Pro Val 
1               5                   10      


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 LCDR1

<400>  13

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 LCDR2

<400>  14

Arg Asn Asn 
1           


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-012 LCDR3

<400>  15

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 LCDR1

<400>  16

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 LCDR2

<400>  17

Ser Asn Asp 
1           


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-017 LCDR3

<400>  18

Ala Ala Trp Asp Asp Ser Leu Asn Ala Val Val 
1               5                   10      


<210>  19
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14011 Heavy chain variable region

<400>  19

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Val Ser Gly Phe Ser Phe Thr Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Asp Ala Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Ile 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Asp Pro Gly Tyr Asp Ser Arg Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14011 Light chain variable region

<400>  20

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  21
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14012 hevay chain variable region

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ser Gly Tyr Thr Thr Asn Trp Tyr Pro Gly Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14012 light chain variable region

<400>  22

Ser Tyr Val Pro Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  23
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14017 hevay chain variable region

<400>  23

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asp Tyr Asn Tyr Leu Pro Ser Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR14017 light chain variable region

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


