                               SEQUENCE LISTING



<110> GENIA TECHNOLOGIES, INC.

 

<120> EXONUCLEASE DEFICIENT POLYMERASES



<130> P33452-WO



<140>

<141>



<150> 62/301,475

<151> 2016-02-29



<160> 14    



<170> PatentIn version 3.5



<210> 1

<211> 727

<212> PRT

<213> Clostridium phage phiCPV4



<400> 1

Met Asp Lys His Thr Gln Tyr Val Lys Glu His Ser Phe Asn Tyr Asp 

1               5                   10                  15      





Glu Tyr Lys Lys Ala Asn Phe Asp Lys Ile Glu Cys Leu Ile Phe Asp 

            20                  25                  30          





Thr Glu Ser Cys Thr Asn Tyr Glu Asn Asp Asn Thr Gly Ala Arg Val 

        35                  40                  45              





Tyr Gly Trp Gly Leu Gly Val Thr Arg Asn His Asn Met Ile Tyr Gly 

    50                  55                  60                  





Gln Asn Leu Asn Gln Phe Trp Glu Val Cys Gln Asn Ile Phe Asn Asp 

65                  70                  75                  80  





Trp Tyr His Asp Asn Lys His Thr Ile Lys Ile Thr Lys Thr Lys Lys 

                85                  90                  95      





Gly Phe Pro Lys Arg Lys Tyr Ile Lys Phe Pro Ile Ala Val His Asn 

            100                 105                 110         





Leu Gly Trp Asp Val Glu Phe Leu Lys Tyr Ser Leu Val Glu Asn Gly 

        115                 120                 125             





Phe Asn Tyr Asp Lys Gly Leu Leu Lys Thr Val Phe Ser Lys Gly Ala 

    130                 135                 140                 





Pro Tyr Gln Thr Val Thr Asp Val Glu Glu Pro Lys Thr Phe His Ile 

145                 150                 155                 160 





Val Gln Asn Asn Asn Ile Val Tyr Gly Cys Asn Val Tyr Met Asp Lys 

                165                 170                 175     





Phe Phe Glu Val Glu Asn Lys Asp Gly Ser Thr Thr Glu Ile Gly Leu 

            180                 185                 190         





Cys Leu Asp Phe Phe Asp Ser Tyr Lys Ile Ile Thr Cys Ala Glu Ser 

        195                 200                 205             





Gln Phe His Asn Tyr Val His Asp Val Asp Pro Met Phe Tyr Lys Met 

    210                 215                 220                 





Gly Glu Glu Tyr Asp Tyr Asp Thr Trp Arg Ser Pro Thr His Lys Gln 

225                 230                 235                 240 





Thr Thr Leu Glu Leu Arg Tyr Gln Tyr Asn Asp Ile Tyr Met Leu Arg 

                245                 250                 255     





Glu Val Ile Glu Gln Phe Tyr Ile Asp Gly Leu Cys Gly Gly Glu Leu 

            260                 265                 270         





Pro Leu Thr Gly Met Arg Thr Ala Ser Ser Ile Ala Phe Asn Val Leu 

        275                 280                 285             





Lys Lys Met Thr Phe Gly Glu Glu Lys Thr Glu Glu Gly Tyr Ile Asn 

    290                 295                 300                 





Tyr Phe Glu Leu Asp Lys Lys Thr Lys Phe Glu Phe Leu Arg Lys Arg 

305                 310                 315                 320 





Ile Glu Met Glu Ser Tyr Thr Gly Gly Tyr Thr His Ala Asn His Lys 

                325                 330                 335     





Ala Val Gly Lys Thr Ile Asn Lys Ile Gly Cys Ser Leu Asp Ile Asn 

            340                 345                 350         





Ser Ser Tyr Pro Ser Gln Met Ala Tyr Lys Val Phe Pro Tyr Gly Lys 

        355                 360                 365             





Pro Val Arg Lys Thr Trp Gly Arg Lys Pro Lys Thr Glu Lys Asn Glu 

    370                 375                 380                 





Val Tyr Leu Ile Glu Val Gly Phe Asp Phe Val Glu Pro Lys His Glu 

385                 390                 395                 400 





Glu Tyr Ala Leu Asp Ile Phe Lys Ile Gly Ala Val Asn Ser Lys Ala 

                405                 410                 415     





Leu Ser Pro Ile Thr Gly Ala Val Ser Gly Gln Glu Tyr Phe Cys Thr 

            420                 425                 430         





Asn Ile Lys Asp Gly Lys Ala Ile Pro Val Tyr Lys Glu Leu Lys Asp 

        435                 440                 445             





Thr Lys Leu Thr Thr Asn Tyr Asn Val Val Leu Thr Ser Val Glu Tyr 

    450                 455                 460                 





Glu Phe Trp Ile Lys His Phe Asn Phe Gly Val Phe Lys Lys Asp Glu 

465                 470                 475                 480 





Tyr Asp Cys Phe Glu Val Asp Asn Leu Glu Phe Thr Gly Leu Lys Ile 

                485                 490                 495     





Gly Ser Ile Leu Tyr Tyr Lys Ala Glu Lys Gly Lys Phe Lys Pro Tyr 

            500                 505                 510         





Val Asp His Phe Thr Lys Met Lys Val Glu Asn Lys Lys Leu Gly Asn 

        515                 520                 525             





Lys Pro Leu Thr Asn Gln Ala Lys Leu Ile Leu Asn Gly Ala Tyr Gly 

    530                 535                 540                 





Lys Phe Gly Thr Lys Gln Asn Lys Glu Glu Lys Asp Leu Ile Met Asp 

545                 550                 555                 560 





Lys Asn Gly Leu Leu Thr Phe Thr Gly Ser Val Thr Glu Tyr Glu Gly 

                565                 570                 575     





Lys Glu Phe Tyr Arg Pro Tyr Ala Ser Phe Val Thr Ala Tyr Gly Arg 

            580                 585                 590         





Leu Gln Leu Trp Asn Ala Ile Ile Tyr Ala Val Gly Val Glu Asn Phe 

        595                 600                 605             





Leu Tyr Cys Asp Thr Asp Ser Ile Tyr Cys Asn Arg Glu Val Asn Ser 

    610                 615                 620                 





Leu Ile Glu Asp Met Asn Ala Ile Gly Glu Thr Ile Asp Lys Thr Ile 

625                 630                 635                 640 





Leu Gly Lys Trp Asp Val Glu His Val Phe Asp Lys Phe Lys Val Leu 

                645                 650                 655     





Gly Gln Lys Lys Tyr Met Tyr His Asp Cys Lys Glu Asp Lys Thr Asp 

            660                 665                 670         





Leu Lys Cys Cys Gly Leu Pro Ser Asp Ala Arg Lys Ile Ile Ile Gly 

        675                 680                 685             





Gln Gly Phe Asp Glu Phe Tyr Leu Gly Lys Asn Val Glu Gly Lys Lys 

    690                 695                 700                 





Gln Arg Lys Lys Val Ile Gly Gly Cys Leu Leu Leu Asp Thr Leu Phe 

705                 710                 715                 720 





Thr Ile Lys Lys Ile Met Phe 

                725         





<210> 2

<211> 739

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 2

Met His His His His His His His His Ser Gly Gly Ser Asp Lys His 

1               5                   10                  15      





Thr Gln Tyr Val Lys Glu His Ser Phe Asn Tyr Asp Glu Tyr Lys Lys 

            20                  25                  30          





Ala Asn Phe Asp Lys Ile Glu Cys Leu Ile Phe Asp Thr Glu Ser Cys 

        35                  40                  45              





Thr Asn Tyr Glu Asn Asp Asn Thr Gly Ala Arg Val Tyr Gly Trp Gly 

    50                  55                  60                  





Leu Gly Val Thr Arg Asn His Asn Met Ile Tyr Gly Gln Asn Leu Asn 

65                  70                  75                  80  





Gln Phe Trp Glu Val Cys Gln Asn Ile Phe Asn Asp Trp Tyr His Asp 

                85                  90                  95      





Asn Lys His Thr Ile Lys Ile Thr Lys Thr Lys Lys Gly Phe Pro Lys 

            100                 105                 110         





Arg Lys Tyr Ile Lys Phe Pro Ile Ala Val His Asn Leu Gly Trp Asp 

        115                 120                 125             





Val Glu Phe Leu Lys Tyr Ser Leu Val Glu Asn Gly Phe Asn Tyr Asp 

    130                 135                 140                 





Lys Gly Leu Leu Lys Thr Val Phe Ser Lys Gly Ala Pro Tyr Gln Thr 

145                 150                 155                 160 





Val Thr Asp Val Glu Glu Pro Lys Thr Phe His Ile Val Gln Asn Asn 

                165                 170                 175     





Asn Ile Val Tyr Gly Cys Asn Val Tyr Met Asp Lys Phe Phe Glu Val 

            180                 185                 190         





Glu Asn Lys Asp Gly Ser Thr Thr Glu Ile Gly Leu Cys Leu Asp Phe 

        195                 200                 205             





Phe Asp Ser Tyr Lys Ile Ile Thr Cys Ala Glu Ser Gln Phe His Asn 

    210                 215                 220                 





Tyr Val His Asp Val Asp Pro Met Phe Tyr Lys Met Gly Glu Glu Tyr 

225                 230                 235                 240 





Asp Tyr Asp Thr Trp Arg Ser Pro Thr His Lys Gln Thr Thr Leu Glu 

                245                 250                 255     





Leu Arg Tyr Gln Tyr Asn Asp Ile Tyr Met Leu Arg Glu Val Ile Glu 

            260                 265                 270         





Gln Phe Tyr Ile Asp Gly Leu Cys Gly Gly Glu Leu Pro Leu Thr Gly 

        275                 280                 285             





Met Arg Thr Ala Ser Ser Ile Ala Phe Asn Val Leu Lys Lys Met Thr 

    290                 295                 300                 





Phe Gly Glu Glu Lys Thr Glu Glu Gly Tyr Ile Asn Tyr Phe Glu Leu 

305                 310                 315                 320 





Asp Lys Lys Thr Lys Phe Glu Phe Leu Arg Lys Arg Ile Glu Met Glu 

                325                 330                 335     





Ser Tyr Thr Gly Gly Tyr Thr His Ala Asn His Lys Ala Val Gly Lys 

            340                 345                 350         





Thr Ile Asn Lys Ile Gly Cys Ser Leu Asp Ile Asn Ser Ser Tyr Pro 

        355                 360                 365             





Ser Gln Met Ala Tyr Lys Val Phe Pro Tyr Gly Lys Pro Val Arg Lys 

    370                 375                 380                 





Thr Trp Gly Arg Lys Pro Lys Thr Glu Lys Asn Glu Val Tyr Leu Ile 

385                 390                 395                 400 





Glu Val Gly Phe Asp Phe Val Glu Pro Lys His Glu Glu Tyr Ala Leu 

                405                 410                 415     





Asp Ile Phe Lys Ile Gly Ala Val Asn Ser Lys Ala Leu Ser Pro Ile 

            420                 425                 430         





Thr Gly Ala Val Ser Gly Gln Glu Tyr Phe Cys Thr Asn Ile Lys Asp 

        435                 440                 445             





Gly Lys Ala Ile Pro Val Tyr Lys Glu Leu Lys Asp Thr Lys Leu Thr 

    450                 455                 460                 





Thr Asn Tyr Asn Val Val Leu Thr Ser Val Glu Tyr Glu Phe Trp Ile 

465                 470                 475                 480 





Lys His Phe Asn Phe Gly Val Phe Lys Lys Asp Glu Tyr Asp Cys Phe 

                485                 490                 495     





Glu Val Asp Asn Leu Glu Phe Thr Gly Leu Lys Ile Gly Ser Ile Leu 

            500                 505                 510         





Tyr Tyr Lys Ala Glu Lys Gly Lys Phe Lys Pro Tyr Val Asp His Phe 

        515                 520                 525             





Thr Lys Met Lys Val Glu Asn Lys Lys Leu Gly Asn Lys Pro Leu Thr 

    530                 535                 540                 





Asn Gln Ala Lys Leu Ile Leu Asn Gly Ala Tyr Gly Lys Phe Gly Thr 

545                 550                 555                 560 





Lys Gln Asn Lys Glu Glu Lys Asp Leu Ile Met Asp Lys Asn Gly Leu 

                565                 570                 575     





Leu Thr Phe Thr Gly Ser Val Thr Glu Tyr Glu Gly Lys Glu Phe Tyr 

            580                 585                 590         





Arg Pro Tyr Ala Ser Phe Val Thr Ala Tyr Gly Arg Leu Gln Leu Trp 

        595                 600                 605             





Asn Ala Ile Ile Tyr Ala Val Gly Val Glu Asn Phe Leu Tyr Cys Asp 

    610                 615                 620                 





Thr Asp Ser Ile Tyr Cys Asn Arg Glu Val Asn Ser Leu Ile Glu Asp 

625                 630                 635                 640 





Met Asn Ala Ile Gly Glu Thr Ile Asp Lys Thr Ile Leu Gly Lys Trp 

                645                 650                 655     





Asp Val Glu His Val Phe Asp Lys Phe Lys Val Leu Gly Gln Lys Lys 

            660                 665                 670         





Tyr Met Tyr His Asp Cys Lys Glu Asp Lys Thr Asp Leu Lys Cys Cys 

        675                 680                 685             





Gly Leu Pro Ser Asp Ala Arg Lys Ile Ile Ile Gly Gln Gly Phe Asp 

    690                 695                 700                 





Glu Phe Tyr Leu Gly Lys Asn Val Glu Gly Lys Lys Gln Arg Lys Lys 

705                 710                 715                 720 





Val Ile Gly Gly Cys Leu Leu Leu Asp Thr Leu Phe Thr Ile Lys Lys 

                725                 730                 735     





Ile Met Phe 

            





<210> 3

<211> 2220

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 3

atgcatcacc atcatcatca ccaccacagc ggcggttccg acaaacacac gcagtacgtc       60



aaagagcata gcttcaatta tgacgagtat aagaaagcga atttcgacaa gatcgagtgc      120



ctgatctttg acaccgagag ctgcacgaat tatgagaacg ataataccgg tgcacgtgtt      180



tacggttggg gtcttggcgt cacccgcaac cacaatatga tctacggcca aaatctgaat      240



cagttttggg aagtatgcca gaacattttc aatgattggt atcacgacaa caaacatacc      300



attaagatta ccaagaccaa gaaaggcttc ccgaaacgta agtacattaa gtttccgatt      360



gcagttcaca atttgggctg ggatgttgaa ttcctgaagt atagcctggt ggagaatggt      420



ttcaattacg acaagggtct gctgaaaact gtttttagca agggtgcgcc gtaccaaacc      480



gtgaccgatg ttgaggaacc gaaaacgttc catatcgtcc agaataacaa catcgtttat      540



ggttgtaacg tgtatatgga caaattcttt gaggtcgaga acaaagacgg ctctaccacc      600



gagattggcc tgtgcttgga tttcttcgat agctataaga tcatcacgtg tgctgagagc      660



cagttccaca attacgttca tgatgtggat ccaatgttct acaaaatggg tgaagagtat      720



gattacgata cttggcgtag cccgacgcac aagcagacca ccctggagct gcgctaccaa      780



tacaatgata tctatatgct gcgtgaagtc atcgaacagt tttacattga cggtttatgt      840



ggcggcgagc tgccgctgac cggcatgcgc accgcttcca gcattgcgtt caacgtgctg      900



aaaaagatga cctttggtga ggaaaagacg gaagagggct acatcaacta ttttgaattg      960



gacaagaaaa ccaaattcga gtttctgcgt aagcgcattg aaatggaatc gtacaccggt     1020



ggctatacgc acgcaaatca caaagccgtt ggtaagacta ttaacaagat cggttgctct     1080



ttggacatta acagctcata cccttcgcag atggcgtaca aggtctttcc gtatggcaaa     1140



ccggttcgta agacctgggg tcgtaaacca aagaccgaga agaacgaagt ttatctgatt     1200



gaagttggct ttgacttcgt ggagccgaaa cacgaagaat acgcgctgga tatctttaag     1260



attggtgcgg tgaactctaa agcgctgagc ccgatcaccg gcgctgtcag cggtcaagag     1320



tatttctgta cgaacattaa agacggcaaa gcaatcccgg tttacaaaga actgaaggac     1380



accaaattga ccactaacta caatgtcgtg ctgaccagcg tggagtacga gttctggatc     1440



aaacacttca attttggtgt gtttaagaaa gacgagtacg actgtttcga agttgacaat     1500



ctggagttta cgggtctgaa gattggttcc attctgtact acaaggcaga gaaaggcaag     1560



tttaaacctt acgtggatca cttcacgaaa atgaaagtgg agaacaagaa actgggtaat     1620



aagccgctga cgaatcaggc aaagctgatt ctgaacggtg cgtacggcaa attcggcacc     1680



aaacaaaaca aagaagagaa agatttgatc atggataaga acggtttgct gaccttcacg     1740



ggtagcgtca cggaatacga gggtaaagaa ttctatcgtc cgtatgcgag cttcgttact     1800



gcctatggtc gcctgcaact gtggaacgcg attatctacg cggttggtgt ggagaatttt     1860



ctgtactgcg acaccgacag catctattgt aaccgtgaag ttaacagcct cattgaggat     1920



atgaacgcca ttggtgaaac catcgataaa acgattctgg gtaaatggga cgtggagcat     1980



gtctttgata agtttaaggt cctgggccag aagaagtaca tgtatcatga ttgcaaagaa     2040



gataaaacgg acctgaagtg ttgcggtctg ccgagcgatg cccgtaagat tatcattggt     2100



caaggtttcg acgagtttta tctgggcaaa aatgtcgaag gtaagaagca acgcaaaaaa     2160



gtgatcggcg gttgcctgct gctggacacc ctgtttacga tcaagaaaat catgttctaa     2220





<210> 4

<211> 61

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      oligonucleotide"



<400> 4

agagtgatag tatgattatg tagatgtagg atttgatatg tgagtagccg aatgaaacct       60



t                                                                       61





<210> 5

<211> 24

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      oligonucleotide"



<400> 5

ttttcataat catactatca ctct                                              24





<210> 6

<211> 74

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      oligonucleotide"



<400> 6

agagtgatag tatgattatg tagatgtagg atttgatatg tgagtagccg aatgaaacct       60



ttggtttcat tcgg                                                         74





<210> 7

<211> 44

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      oligonucleotide"



<400> 7

ttttcatatc aaatcctaca tctacataat catactatca ctct                        44





<210> 8

<211> 727

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 8

Met Asp Lys His Thr Gln Tyr Val Lys Glu His Ser Phe Asn Tyr Asp 

1               5                   10                  15      





Glu Tyr Lys Lys Ala Asn Phe Asp Lys Ile Glu Cys Leu Ile Phe Asp 

            20                  25                  30          





Thr Glu Ser Cys Thr Asn Tyr Glu Asn Asp Asn Thr Gly Ala Arg Val 

        35                  40                  45              





Tyr Gly Trp Gly Leu Gly Val Thr Arg Asn His Asn Met Ile Tyr Gly 

    50                  55                  60                  





Gln Asn Leu Asn Gln Phe Trp Glu Val Cys Gln Asn Ile Phe Asn Asp 

65                  70                  75                  80  





Trp Tyr His Asp Asn Lys His Thr Ile Lys Ile Thr Lys Thr Lys Lys 

                85                  90                  95      





Gly Phe Pro Lys Arg Lys Tyr Ile Lys Phe Pro Ile Ala Val His Asn 

            100                 105                 110         





Leu Gly Trp Asp Val Glu Phe Leu Lys Tyr Ser Leu Val Glu Asn Gly 

        115                 120                 125             





Phe Asn Tyr Asp Lys Gly Leu Leu Lys Thr Val Phe Ser Lys Gly Ala 

    130                 135                 140                 





Pro Tyr Gln Thr Val Thr Asp Val Glu Glu Pro Lys Thr Phe His Ile 

145                 150                 155                 160 





Val Gln Asn Asn Asn Ile Val Tyr Gly Cys Asn Val Tyr Met Asp Lys 

                165                 170                 175     





Phe Phe Glu Val Glu Asn Lys Asp Gly Ser Thr Thr Glu Ile Gly Leu 

            180                 185                 190         





Cys Leu Asp Phe Phe Asp Ser Tyr Lys Ile Ile Thr Cys Ala Glu Ser 

        195                 200                 205             





Gln Phe His Asn Tyr Val His Asp Val Asp Pro Met Phe Tyr Lys Met 

    210                 215                 220                 





Gly Glu Glu Tyr Asp Tyr Asp Thr Trp Arg Ser Pro Thr His Lys Gln 

225                 230                 235                 240 





Thr Thr Leu Glu Leu Arg Tyr Gln Tyr Asn Asp Ile Tyr Met Leu Arg 

                245                 250                 255     





Glu Val Ile Glu Gln Phe Tyr Ile Asp Gly Leu Cys Gly Gly Glu Leu 

            260                 265                 270         





Pro Leu Thr Gly Met Arg Thr Ala Ser Ser Ile Ala Phe Asn Val Leu 

        275                 280                 285             





Lys Lys Met Thr Phe Gly Glu Glu Lys Thr Glu Glu Gly Tyr Ile Asn 

    290                 295                 300                 





Tyr Phe Glu Leu Asp Lys Lys Thr Lys Phe Glu Phe Leu Arg Lys Arg 

305                 310                 315                 320 





Ile Glu Met Glu Ser Tyr Thr Gly Gly Tyr Thr His Ala Asn His Lys 

                325                 330                 335     





Ala Val Gly Lys Thr Ile Asn Lys Ile Gly Cys Ser Leu Asp Ile Asn 

            340                 345                 350         





Ser Ala Tyr Pro Ser Gln Met Ala Tyr Lys Val Phe Pro Tyr Gly Lys 

        355                 360                 365             





Pro Val Arg Lys Thr Trp Gly Arg Lys Pro Lys Thr Glu Lys Asn Glu 

    370                 375                 380                 





Val Tyr Leu Ile Glu Val Gly Phe Asp Phe Val Glu Pro Lys His Glu 

385                 390                 395                 400 





Glu Tyr Ala Leu Asp Ile Phe Lys Ile Gly Ala Val Asn Ser Lys Ala 

                405                 410                 415     





Leu Ser Pro Ile Thr Gly Ala Val Ser Gly Gln Glu Tyr Phe Cys Thr 

            420                 425                 430         





Asn Ile Lys Asp Gly Lys Ala Ile Pro Val Tyr Lys Glu Leu Lys Asp 

        435                 440                 445             





Thr Lys Leu Thr Thr Asn Tyr Asn Val Val Leu Thr Ser Val Glu Tyr 

    450                 455                 460                 





Glu Phe Trp Ile Lys His Phe Asn Phe Gly Val Phe Lys Lys Asp Glu 

465                 470                 475                 480 





Tyr Asp Cys Phe Glu Val Asp Asn Leu Glu Phe Thr Gly Leu Lys Ile 

                485                 490                 495     





Gly Ser Ile Leu Tyr Tyr Lys Ala Glu Lys Gly Lys Phe Lys Pro Tyr 

            500                 505                 510         





Val Asp His Phe Met Lys Met Lys Val Glu Asn Lys Lys Leu Gly Asn 

        515                 520                 525             





Lys Pro Leu Thr Asn Gln Phe Lys Leu Ile Leu Asn Gly Ala Tyr Gly 

    530                 535                 540                 





Lys Phe Gly Thr Lys Gln Asn Lys Glu Glu Lys Asp Leu Ile Met Asp 

545                 550                 555                 560 





Lys Asn Gly Leu Leu Thr Phe Thr Gly Ser Val Thr Glu Tyr Glu Gly 

                565                 570                 575     





Lys Glu Phe Tyr Arg Pro Tyr Ala Ser Phe Val Thr Ala Tyr Gly Arg 

            580                 585                 590         





Leu Gln Leu Trp Asn Ala Ile Ile Tyr Ala Val Gly Val Glu Asn Phe 

        595                 600                 605             





Leu Tyr Cys Asp Thr Asp Ser Ile Tyr Cys Asn Arg Glu Val Asn Ser 

    610                 615                 620                 





Leu Ile Glu Asp Met Asn Ala Ile Gly Glu Thr Ile Asp Lys Thr Ile 

625                 630                 635                 640 





Leu Gly Lys Trp Asp Val Glu His Val Phe Asp Lys Phe Lys Val Leu 

                645                 650                 655     





Gly Gln Lys Lys Tyr Met Tyr His Asp Cys Lys Glu Asp Lys Thr Asp 

            660                 665                 670         





Leu Lys Cys Cys Gly Leu Pro Ser Asp Ala Arg Lys Ile Ile Ile Gly 

        675                 680                 685             





Gln Gly Phe Asp Glu Phe Tyr Leu Gly Lys Asn Val Glu Gly Lys Lys 

    690                 695                 700                 





Gln Arg Lys Lys Val Ile Gly Gly Cys Leu Leu Leu Asp Thr Leu Phe 

705                 710                 715                 720 





Thr Ile Lys Lys Ile Met Phe 

                725         





<210> 9

<211> 150

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 9

cgctcacact cgctctctct acgtcactca tctcactact gcactctact cgacactcta       60



ctacagctag ctctctctac gacgcacatc acgctactac actctgctct acactacact      120



ctctctacat cgctctacta cgctcatcta                                       150





<210> 10

<211> 18

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 10

gtgtgagcgt agatgagc                                                     18





<210> 11

<211> 727

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 11

Met Asp Lys His Thr Gln Tyr Val Lys Glu His Ser Phe Asn Tyr Asp 

1               5                   10                  15      





Glu Tyr Lys Lys Ala Asn Phe Asp Lys Ile Glu Cys Leu Ile Phe Ala 

            20                  25                  30          





Thr Glu Ser Cys Thr Asn Tyr Glu Asn Asp Asn Thr Gly Ala Arg Val 

        35                  40                  45              





Tyr Gly Trp Gly Leu Gly Val Thr Arg Asn His Asn Met Ile Tyr Gly 

    50                  55                  60                  





Gln Asn Leu Asn Gln Phe Trp Glu Val Cys Gln Asn Ile Phe Asn Asp 

65                  70                  75                  80  





Trp Tyr His Asp Asn Lys His Thr Ile Lys Ile Thr Lys Thr Lys Lys 

                85                  90                  95      





Gly Phe Pro Lys Arg Lys Tyr Ile Lys Phe Pro Ile Ala Val His Asn 

            100                 105                 110         





Leu Gly Trp Asp Val Glu Phe Leu Lys Tyr Ser Leu Val Glu Asn Gly 

        115                 120                 125             





Phe Asn Tyr Asp Lys Gly Leu Leu Lys Thr Val Phe Ser Lys Gly Ala 

    130                 135                 140                 





Pro Tyr Gln Thr Val Thr Asp Val Glu Glu Pro Lys Thr Phe His Ile 

145                 150                 155                 160 





Val Gln Asn Asn Asn Ile Val Tyr Gly Cys Asn Val Tyr Met Asp Lys 

                165                 170                 175     





Phe Phe Glu Val Glu Asn Lys Asp Gly Ser Thr Thr Glu Ile Gly Leu 

            180                 185                 190         





Cys Leu Asp Phe Phe Asp Ser Tyr Lys Ile Ile Thr Cys Ala Glu Ser 

        195                 200                 205             





Gln Phe His Asn Tyr Val His Asp Val Asp Pro Met Phe Tyr Lys Met 

    210                 215                 220                 





Gly Glu Glu Tyr Asp Tyr Asp Thr Trp Arg Ser Pro Thr His Lys Gln 

225                 230                 235                 240 





Thr Thr Leu Glu Leu Arg Tyr Gln Tyr Asn Asp Ile Tyr Met Leu Arg 

                245                 250                 255     





Glu Val Ile Glu Gln Phe Tyr Ile Asp Gly Leu Cys Gly Gly Glu Leu 

            260                 265                 270         





Pro Leu Thr Gly Met Arg Thr Ala Ser Ser Ile Ala Phe Asn Val Leu 

        275                 280                 285             





Lys Lys Met Thr Phe Gly Glu Glu Lys Thr Glu Glu Gly Tyr Ile Asn 

    290                 295                 300                 





Tyr Phe Glu Leu Asp Lys Lys Thr Lys Phe Glu Phe Leu Arg Lys Arg 

305                 310                 315                 320 





Ile Glu Met Glu Ser Tyr Thr Gly Gly Tyr Thr His Ala Asn His Lys 

                325                 330                 335     





Ala Val Gly Lys Thr Ile Asn Lys Ile Gly Cys Ser Leu Asp Ile Asn 

            340                 345                 350         





Ser Ala Tyr Pro Ser Gln Met Ala Tyr Lys Val Phe Pro Tyr Gly Lys 

        355                 360                 365             





Pro Val Arg Lys Thr Trp Gly Arg Lys Pro Lys Thr Glu Lys Asn Glu 

    370                 375                 380                 





Val Tyr Leu Ile Glu Val Gly Phe Asp Phe Val Glu Pro Lys His Glu 

385                 390                 395                 400 





Glu Tyr Ala Leu Asp Ile Phe Lys Ile Gly Ala Val Asn Ser Lys Ala 

                405                 410                 415     





Leu Ser Pro Ile Thr Gly Ala Val Ser Gly Gln Glu Tyr Phe Cys Thr 

            420                 425                 430         





Asn Ile Lys Asp Gly Lys Ala Ile Pro Val Tyr Lys Glu Leu Lys Asp 

        435                 440                 445             





Thr Lys Leu Thr Thr Asn Tyr Asn Val Val Leu Thr Ser Val Glu Tyr 

    450                 455                 460                 





Glu Phe Trp Ile Lys His Phe Asn Phe Gly Val Phe Lys Lys Asp Glu 

465                 470                 475                 480 





Tyr Asp Cys Phe Glu Val Asp Asn Leu Glu Phe Thr Gly Leu Lys Ile 

                485                 490                 495     





Gly Ser Ile Leu Tyr Tyr Lys Ala Glu Lys Gly Lys Phe Lys Pro Tyr 

            500                 505                 510         





Val Asp His Phe Met Lys Met Lys Val Glu Asn Lys Lys Leu Gly Asn 

        515                 520                 525             





Lys Pro Leu Thr Asn Gln Phe Lys Leu Ile Leu Asn Gly Ala Tyr Gly 

    530                 535                 540                 





Lys Phe Gly Thr Lys Gln Asn Lys Glu Glu Lys Asp Leu Ile Met Asp 

545                 550                 555                 560 





Lys Asn Gly Leu Leu Thr Phe Thr Gly Ser Val Thr Glu Tyr Glu Gly 

                565                 570                 575     





Lys Glu Phe Tyr Arg Pro Tyr Ala Ser Phe Val Thr Ala Tyr Gly Arg 

            580                 585                 590         





Leu Gln Leu Trp Asn Ala Ile Ile Tyr Ala Val Gly Val Glu Asn Phe 

        595                 600                 605             





Leu Tyr Cys Asp Thr Asp Ser Ile Tyr Cys Asn Arg Glu Val Asn Ser 

    610                 615                 620                 





Leu Ile Glu Asp Met Asn Ala Ile Gly Glu Thr Ile Asp Lys Thr Ile 

625                 630                 635                 640 





Leu Gly Lys Trp Asp Val Glu His Val Phe Asp Lys Phe Lys Val Leu 

                645                 650                 655     





Gly Gln Lys Lys Tyr Met Tyr His Asp Cys Lys Glu Asp Lys Thr Asp 

            660                 665                 670         





Leu Lys Cys Cys Gly Leu Pro Ser Asp Ala Arg Lys Ile Ile Ile Gly 

        675                 680                 685             





Gln Gly Phe Asp Glu Phe Tyr Leu Gly Lys Asn Val Glu Gly Lys Lys 

    690                 695                 700                 





Gln Arg Lys Lys Val Ile Gly Gly Cys Leu Leu Leu Asp Thr Leu Phe 

705                 710                 715                 720 





Thr Ile Lys Lys Ile Met Phe 

                725         





<210> 12

<211> 15

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"





<220>

<221> MISC_FEATURE

<222> (1)..(15)

<223> /note="This sequence may encompass 1-3 'Gly Gly Gly Gly Ser'

      repeating units"



<400> 12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

1               5                   10                  15  





<210> 13

<211> 5

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"



<400> 13

Arg Ser Lys Leu Gly 

1               5   





<210> 14

<211> 14

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      oligonucleotide"



<400> 14

ttggtttcat tcgg                                                         14





