                         SEQUENCE LISTING

<110>  Cellmid Limited
 
<120>  Methods of treating bone diseases, disorders and/or injuries and 
       reagents therefor

<130>  175781

<150>  AU 2016900755
<151>  2016-03-01

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Lys Lys Asp Lys Val Lys Lys Gly Gly Pro Gly Ser Glu Cys Ala 
1               5                   10                  15      


Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser Ser Lys Asp Cys Gly Val 
            20                  25                  30          


Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln Thr Gln Arg Ile Arg Cys 
        35                  40                  45              


Arg Val Pro Cys Asn Trp Lys Lys Glu Phe Gly Ala Asp Cys Lys Tyr 
    50                  55                  60                  


Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly Gly Thr Gly Thr Lys Val 
65                  70                  75                  80  


Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr Asn Ala Gln Cys Gln Glu 
                85                  90                  95      


Thr Ile Arg Val Thr Lys Pro Cys Thr Pro Lys Thr Lys Ala Lys Ala 
            100                 105                 110         


Lys Ala Lys Lys Gly Lys Gly Lys Asp 
        115                 120     


<210>  2
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 Heavy chain variable region

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro His Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Asn Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly His Tyr Asp Glu Gly Tyr Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 Light chain variable region

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Phe Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VH CDR1

<400>  4

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VH CDR2

<400>  5

Ile Asn Pro His Asn Gly Gly Thr 
1               5               


<210>  6
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VH CDR3

<400>  6

Val Arg Gly Gly His Tyr Asp Glu Gly Tyr Phe Glu Tyr 
1               5                   10              


<210>  7
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VL CDR1

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala 
1               5                   


<210>  8
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VL CDR2

<400>  8

Gly Asn Ile His Asn Tyr 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP9 VL CDR3

<400>  9

Asn Ala Lys 
1           


<210>  10
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 Heavy chain variable region

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Ser Ser Phe Asp Trp Leu Ala Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  11
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 Light chain variable region

<400>  11

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VH CDR1

<400>  12

Gly Tyr Ser Phe Thr Gly Tyr Phe 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VH CDR2

<400>  13

Ile Asn Pro Tyr Asn Gly Asp Thr 
1               5               


<210>  14
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VH CDR3

<400>  14

Ala Arg Glu Ala Gly Gly Ser Ser Phe Asp Trp Leu Ala Tyr 
1               5                   10                  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VL CDR1

<400>  15

Glu Asn Val Val Thr Tyr 
1               5       


<210>  16
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VL CDR2

<400>  16

Gly Ala Ser 
1           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP10 VL CDR3

<400>  17

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  18
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 Heavy chain variable region

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Asn Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  19
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 Light chain variable region v1

<400>  19

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 Light chain variable region v2

<400>  20

Ser Ile Val Met Thr Gln Thr Pro Asn Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VH CDR1

<400>  21

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VH CDR2

<400>  22

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  23
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VH CDR3

<400>  23

Ala Arg Trp Ser Tyr Ser Asn Pro Tyr Phe Asp Tyr 
1               5                   10          


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VL CDR1

<400>  24

Glu Asn Val Val Thr Tyr 
1               5       


<210>  25
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VL CDR2

<400>  25

Gly Ala Ser 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IP13 VL CDR3

<400>  26

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VH CDR1

<400>  27

Asp Tyr Phe Leu His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VH CDR2

<400>  28

Arg Ile Asp Pro Glu Asp Ser Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VH CDR3

<400>  29

Asn Tyr Gly Gly Gly Gly Phe Ala Tyr 
1               5                   


<210>  30
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VL CDR1

<400>  30

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VL CDR2

<400>  31

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-1 VL CDR3

<400>  32

Gln Gln His Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VH CDR1

<400>  33

Ser Tyr Trp Met Asn 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VH CDR2

<400>  34

Met Ile His Pro Ser Asp Ser Glu Thr Ile Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VH CDR3

<400>  35

Trp Ser Ala Lys Arg Gly Asp Phe 
1               5               


<210>  36
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VL CDR1

<400>  36

Ser Tyr Trp Met Asn 
1               5   


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VL CDR2

<400>  37

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CSM-4 VL CDR3

<400>  38

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


