                         SEQUENCE LISTING

<110>  Aromyx Corporation
 
<120>  Biosensor for Detecting Smell, Scent and Taste

<130>  ARX.0007

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAGTAG

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR Motiff

<400>  2

Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
1               5                   10  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR Motiff first Intracellular loop

<400>  3

Leu His Thr Pro Met Tyr 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR Motiff at beginning of TM3

<400>  4

Phe Ser Thr Cys Ser Ser His 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR Motiff in TM7

<400>  5

Pro Met Leu Asn Pro Phe 
1               5       


<210>  6
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Glu Asn Asn Gln Ser Ser Thr Leu Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Val Thr Gly Gln Gln Glu Gln Glu Asp Phe Phe Tyr Ile Leu Phe Leu 
            20                  25                  30          


Phe Ile Tyr Pro Ile Thr Leu Ile Gly Asn Leu Leu Ile Val Leu Ala 
        35                  40                  45              


Ile Cys Ser Asp Val Arg Leu His Asn Pro Met Tyr Phe Leu Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Ile Phe Phe Ser Ser Val Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn His Leu Leu Gly Ser Lys Ser Ile Ser Phe Gly Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 
            100                 105                 110         


Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Ser Cys Ile Trp Leu 
    130                 135                 140                 


Ile Ala Gly Ser Trp Val Ile Gly Asn Ala Asn Ala Leu Pro His Thr 
145                 150                 155                 160 


Leu Leu Thr Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn 
                165                 170                 175     


Phe Tyr Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


His Phe His Val Lys Met Met Tyr Leu Gly Val Gly Ile Phe Ser Val 
        195                 200                 205             


Pro Leu Leu Cys Ile Ile Val Ser Tyr Ile Arg Val Phe Ser Thr Val 
    210                 215                 220                 


Phe Gln Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly 
                245                 250                 255     


Thr Tyr Phe Arg Pro Leu Thr Asn Tyr Ser Leu Lys Asp Ala Val Ile 
            260                 265                 270         


Thr Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg Lys Leu Phe Asn 
    290                 295                 300                 


Lys Arg Ile Ser Ser 
305                 


<210>  7
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Trp Arg Asn His Ser Gly Arg Val Ser Glu Phe Val Leu Leu 
1               5                   10                  15      


Gly Phe Pro Ala Pro Ala Pro Leu Gln Val Leu Leu Phe Ala Leu Leu 
            20                  25                  30          


Leu Leu Ala Tyr Val Leu Val Leu Thr Glu Asn Thr Leu Ile Ile Met 
        35                  40                  45              


Ala Ile Arg Asn His Ser Thr Leu His Lys Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile Pro 
65                  70                  75                  80  


Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Asp His Gly Gln Leu 
                85                  90                  95      


Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly Leu 
            100                 105                 110         


Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr 
        115                 120                 125             


Met Ala Ile Cys Tyr Pro Leu His Tyr Pro Val Ile Val Ser Gly Arg 
    130                 135                 140                 


Leu Cys Val Gln Met Ala Ala Gly Ser Trp Ala Gly Gly Phe Gly Ile 
145                 150                 155                 160 


Ser Met Val Lys Val Phe Leu Ile Ser Gly Leu Ser Tyr Cys Gly Pro 
                165                 170                 175     


Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu 
            180                 185                 190         


Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Ile Leu Ala 
        195                 200                 205             


Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr Val 
    210                 215                 220                 


Ala Ile Thr Gly Ala Val Met His Ile Pro Ser Ala Ala Gly Arg Tyr 
225                 230                 235                 240 


Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile Phe 
                245                 250                 255     


Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser Ala 
            260                 265                 270         


Phe Asp Thr Asn Lys Leu Val Ser Val Leu Tyr Ala Val Ile Val Pro 
        275                 280                 285             


Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn Gln Glu Val Lys Arg 
    290                 295                 300                 


Ala Leu Cys Cys Thr Leu His Leu Tyr Gln His Gln Asp Pro Asp Pro 
305                 310                 315                 320 


Lys Lys Ala Ser Arg Asn Val 
                325         


<210>  8
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met Ile Lys Lys Asn Ala Ser Ser Glu Asp Phe Phe Ile Leu Leu 
1               5                   10                  15      


Gly Phe Ser Asn Trp Pro Gln Leu Glu Val Val Leu Phe Val Val Ile 
            20                  25                  30          


Leu Ile Phe Tyr Leu Met Thr Leu Thr Gly Asn Leu Phe Ile Ile Ile 
        35                  40                  45              


Leu Ser Tyr Val Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Ser Ile Pro 
65                  70                  75                  80  


Gln Leu Leu Val Asn Leu Arg Gly Pro Glu Lys Thr Ile Ser Tyr Ala 
                85                  90                  95      


Gly Cys Met Val Gln Leu Tyr Phe Val Leu Ala Leu Gly Ile Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys 
        115                 120                 125             


Arg Pro Leu His Tyr Thr Val Leu Met His Pro Arg Phe Cys His Leu 
    130                 135                 140                 


Leu Val Ala Ala Ser Trp Val Ile Gly Phe Thr Ile Ser Ala Leu His 
145                 150                 155                 160 


Ser Ser Phe Thr Phe Trp Val Pro Leu Cys Gly His Arg Leu Val Asp 
                165                 170                 175     


His Phe Phe Cys Glu Val Pro Ala Leu Leu Arg Leu Ser Cys Val Asp 
            180                 185                 190         


Thr His Ala Asn Glu Leu Thr Leu Met Val Met Ser Ser Ile Phe Val 
        195                 200                 205             


Leu Ile Pro Leu Ile Leu Ile Leu Thr Thr Tyr Gly Ala Ile Ala Arg 
    210                 215                 220                 


Ala Val Leu Ser Met Gln Ser Thr Thr Gly Leu Gln Lys Val Phe Arg 
225                 230                 235                 240 


Thr Cys Gly Ala His Leu Met Val Val Ser Leu Phe Phe Ile Pro Val 
                245                 250                 255     


Met Cys Met Tyr Leu Gln Pro Pro Ser Glu Asn Ser Pro Asp Gln Gly 
            260                 265                 270         


Lys Phe Ile Ala Leu Phe Tyr Thr Val Val Thr Pro Ser Leu Asn Pro 
        275                 280                 285             


Leu Ile Tyr Thr Leu Arg Asn Lys His Val Lys Gly Ala Ala Lys Arg 
    290                 295                 300                 


Leu Leu Gly Trp Glu Trp Gly Lys 
305                 310         


<210>  9
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Gln Ser Asn Tyr Ser Ser Leu His Gly Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asn His Pro Lys Met Glu Met Ile Leu Ser Gly Val Val Ala 
            20                  25                  30          


Ile Phe Tyr Leu Ile Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Ala 
        35                  40                  45              


Ser Leu Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Arg 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln 
65                  70                  75                  80  


Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Ile Ile Gln Leu Tyr Val Tyr Met Trp Leu Gly Ser Val Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys 
        115                 120                 125             


Pro Leu His Tyr Phe Val Val Met Asn Pro His Leu Cys Leu Lys Met 
    130                 135                 140                 


Ile Ile Met Ile Trp Ser Ile Ser Leu Ala Asn Ser Val Val Leu Cys 
145                 150                 155                 160 


Thr Leu Thr Leu Asn Leu Pro Thr Cys Gly Asn Asn Ile Leu Asp His 
                165                 170                 175     


Phe Leu Cys Glu Leu Pro Ala Leu Val Lys Ile Ala Cys Val Asp Thr 
            180                 185                 190         


Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Ile Ile Val Leu 
        195                 200                 205             


Thr Pro Leu Ile Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Lys Ala 
    210                 215                 220                 


Val Leu Arg Thr Lys Ser Lys Ala Ser Gln Arg Lys Ala Met Asn Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Thr Val Val Ser Met Phe Tyr Gly Thr Ile Ile 
                245                 250                 255     


Tyr Met Tyr Leu Gln Pro Gly Asn Arg Ala Ser Lys Asp Gln Gly Lys 
            260                 265                 270         


Phe Leu Thr Leu Phe Tyr Thr Val Ile Thr Pro Ser Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys Lys Leu 
    290                 295                 300                 


Met Arg Phe His His Lys Ser Thr Lys Ile Lys Arg Asn Cys Lys Ser 
305                 310                 315                 320 


<210>  10
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Thr Gly Asn Asp Thr Thr Val Val Glu Phe Thr Leu Leu Gly 
1               5                   10                  15      


Leu Ser Glu Asp Thr Thr Val Cys Ala Ile Leu Phe Leu Val Phe Leu 
            20                  25                  30          


Gly Ile Tyr Val Val Thr Leu Met Gly Asn Ile Ser Ile Ile Val Leu 
        35                  40                  45              


Ile Arg Arg Ser His His Leu His Thr Pro Met Tyr Ile Phe Leu Cys 
    50                  55                  60                  


His Leu Ala Phe Val Asp Ile Gly Tyr Ser Ser Ser Val Thr Pro Val 
65                  70                  75                  80  


Met Leu Met Ser Phe Leu Arg Lys Glu Thr Ser Leu Pro Val Ala Gly 
                85                  90                  95      


Cys Val Ala Gln Leu Cys Ser Val Val Thr Phe Gly Thr Ala Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 
        115                 120                 125             


Pro Leu Leu Tyr Ser Thr Cys Met Ser Pro Gly Val Cys Ile Ile Leu 
    130                 135                 140                 


Val Gly Met Ser Tyr Leu Gly Gly Cys Val Asn Ala Trp Thr Phe Ile 
145                 150                 155                 160 


Gly Cys Leu Leu Arg Leu Ser Phe Cys Gly Pro Asn Lys Val Asn His 
                165                 170                 175     


Phe Phe Cys Asp Tyr Ser Pro Leu Leu Lys Leu Ala Cys Ser His Asp 
            180                 185                 190         


Phe Thr Phe Glu Ile Ile Pro Ala Ile Ser Ser Gly Ser Ile Ile Val 
        195                 200                 205             


Ala Thr Val Cys Val Ile Ala Ile Ser Tyr Ile Tyr Ile Leu Ile Thr 
    210                 215                 220                 


Ile Leu Lys Met His Ser Thr Lys Gly Arg His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Thr Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Thr Ile Thr 
                245                 250                 255     


Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr Ser Thr Asp Gln Asn Lys 
            260                 265                 270         


Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu 
    290                 295                 300                 


Leu Arg Ile Lys Ile Phe Ser 
305                 310     


<210>  11
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N terminal sequence of rat RI7

<400>  11

Met Glu Arg Arg Asn His Ser Gly Arg Val Ser Glu Phe Val Leu Leu 
1               5                   10                  15      


Gly Phe Pro Ala Pro Ala Pro Leu Arg Val Leu Leu Phe Phe Leu Ser 
            20                  25                  30          


Leu Leu Ala Tyr Val Leu Val Leu Thr Glu Asn Met Leu Ile Ile Ile 
        35                  40                  45              


Ala Ile Arg Asn His Pro Thr Leu His Lys Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile Pro 
65                  70                  75                  80  


Lys Met Leu Ala Gly Phe Ile Gly Ser Lys Glu Asn His Gly Gln Leu 
                85                  90                  95      


Ile Ser Phe Glu 
            100 


<210>  12
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of human OR6A2 and OR1A1

<400>  12

Met Glu Trp Arg Asn His Ser Gly Arg Val Ser Glu Phe Val Leu Leu 
1               5                   10                  15      


Gly Phe Pro Ala Pro Ala Pro Leu Gln Val Leu Leu Phe Ala Leu Leu 
            20                  25                  30          


Leu Leu Ala Tyr Val Leu Val Leu Thr Glu Asn Thr Leu Ile Ile Met 
        35                  40                  45              


Ala Ile Arg Asn His Ser Thr His Asn Pro Met Tyr Phe Leu Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Ile Phe Phe Ser Ser Val Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn His Leu Leu Gly Ser Lys Ser Ile Ser Phe Gly Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 
            100                 105                 110         


Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Ser Cys Ile Trp Leu 
    130                 135                 140                 


Ile Ala Gly Ser Trp Val Ile Gly Asn Ala Asn Ala Leu Pro His Thr 
145                 150                 155                 160 


Leu Leu Thr Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn 
                165                 170                 175     


Phe Tyr Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


His Phe His Val Lys Met Met Tyr Leu Gly Val Gly Ile Phe Ser Val 
        195                 200                 205             


Pro Leu Leu Cys Ile Ile Val Ser Tyr Ile Arg Val Phe Ser Thr Val 
    210                 215                 220                 


Phe Gln Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly 
                245                 250                 255     


Thr Tyr Phe Arg Pro Leu Thr Asn Tyr Ser Leu Lys Asp Ala Val Ile 
            260                 265                 270         


Thr Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg Lys Leu Phe Asn 
    290                 295                 300                 


Lys Arg Ile Ser Ser 
305                 


<210>  13
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Cys Leu Gly Gly Asn Ser Lys Thr Thr Glu Asp Gln Gly Val 
1               5                   10                  15      


Asp Glu Lys Glu Arg Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu 
            20                  25                  30          


Gln Lys Glu Arg Leu Ala Tyr Lys Ala Thr His Arg Leu Leu Leu Leu 
        35                  40                  45              


Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile 
    50                  55                  60                  


Leu His Val Asn Gly Phe Asn Pro Glu Glu Lys Lys Gln Lys Ile Leu 
65                  70                  75                  80  


Asp Ile Arg Lys Asn Val Lys Asp Ala Ile Val Thr Ile Val Ser Ala 
                85                  90                  95      


Met Ser Thr Ile Ile Pro Pro Val Pro Leu Ala Asn Pro Glu Asn Gln 
            100                 105                 110         


Phe Arg Ser Asp Tyr Ile Lys Ser Ile Ala Pro Ile Thr Asp Phe Glu 
        115                 120                 125             


Tyr Ser Gln Glu Phe Phe Asp His Val Lys Lys Leu Trp Asp Asp Glu 
    130                 135                 140                 


Gly Val Lys Ala Cys Phe Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
145                 150                 155                 160 


Cys Ala Gln Tyr Phe Leu Glu Arg Ile Asp Ser Val Ser Leu Val Asp 
                165                 170                 175     


Tyr Thr Pro Thr Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
            180                 185                 190         


Gly Ile Phe Glu Thr Arg Phe Gln Val Asp Lys Val Asn Phe His Met 
        195                 200                 205             


Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
    210                 215                 220                 


Phe Asn Asp Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser Tyr 
225                 230                 235                 240 


Asn Met Val Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu Ser 
                245                 250                 255     


Leu Asp Leu Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
            260                 265                 270         


Ser Ile Ile Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys Val 
        275                 280                 285             


Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala Asn 
    290                 295                 300                 


Tyr Thr Val Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro Lys 
305                 310                 315                 320 


Val Thr Arg Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile Ser 
                325                 330                 335     


Thr Ala Thr Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr Cys 
            340                 345                 350         


Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp 
        355                 360                 365             


Ile Ile Gln Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
    370                 375                 380     


<210>  14
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn 
1               5                   10                  15      


Gln Ile Arg Asp Ala Arg Lys Ala Cys Gly Asp Ser Thr Leu Thr Gln 
            20                  25                  30          


Ile Thr Ala Gly Leu Asp Pro Val Gly Arg Ile Gln Met Arg Thr Arg 
        35                  40                  45              


Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Gly 
    50                  55                  60                  


Thr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile 
65                  70                  75                  80  


Ile Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu Arg 
                85                  90                  95      


Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Phe Val 
            100                 105                 110         


Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Ser Leu Lys Thr 
        115                 120                 125             


Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr Gly 
    130                 135                 140                 


Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Gln Ile Ile Thr Ser 
145                 150                 155                 160 


Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln 
                165                 170                 175     


Thr Val Gly Phe Ala Gly His Ser Gly Asp Val Met Ser Leu Ser Leu 
            180                 185                 190         


Ala Pro Asp Gly Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser Ile 
        195                 200                 205             


Lys Leu Trp Asp Val Arg Asp Ser Met Cys Arg Gln Thr Phe Ile Gly 
    210                 215                 220                 


His Glu Ser Asp Ile Asn Ala Val Ala Phe Phe Pro Asn Gly Tyr Ala 
225                 230                 235                 240 


Phe Thr Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg 
                245                 250                 255     


Ala Asp Gln Glu Leu Leu Met Tyr Ser His Asp Asn Ile Ile Cys Gly 
            260                 265                 270         


Ile Thr Ser Val Ala Phe Ser Arg Ser Gly Arg Leu Leu Leu Ala Gly 
        275                 280                 285             


Tyr Asp Asp Phe Asn Cys Asn Ile Trp Asp Ala Met Lys Gly Asp Arg 
    290                 295                 300                 


Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly Val 
305                 310                 315                 320 


Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu 
                325                 330                 335     


Lys Ile Trp Asn 
            340 


<210>  15
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Gly Ser Ser Ser Val Ala Ala Met Lys Lys Val Val Gln Gln 
1               5                   10                  15      


Leu Arg Leu Glu Ala Gly Leu Asn Arg Val Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Asp Leu Lys Gln Phe Cys Leu Gln Asn Ala Gln His Asp Pro Leu 
        35                  40                  45              


Leu Thr Gly Val Ser Ser Ser Thr Asn Pro Phe Arg Pro Gln Lys Val 
    50                  55                  60                  


Cys Ser Phe Leu 
65              


<210>  16
<211>  1144
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn  Lys Glu Asp Lys Ser  Glu Arg Glu 
        995                 1000                 1005             


Arg Trp  Gln His Leu Ala Asp  Leu Ala Asp Phe Ala  Leu Ala Met 
    1010                 1015                 1020             


Lys Asp  Thr Leu Thr Asn Ile  Asn Asn Gln Ser Phe  Asn Asn Phe 
    1025                 1030                 1035             


Met Leu  Arg Ile Gly Met Asn  Lys Gly Gly Val Leu  Ala Gly Val 
    1040                 1045                 1050             


Ile Gly  Ala Arg Lys Pro His  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1055                 1060                 1065             


Asn Val  Ala Ser Arg Met Glu  Ser Thr Gly Val Met  Gly Asn Ile 
    1070                 1075                 1080             


Gln Val  Val Glu Glu Thr Gln  Val Ile Leu Arg Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Arg Phe  Val Arg Arg Gly Pro  Ile Phe Val Lys Gly  Lys Gly Glu 
    1100                 1105                 1110             


Leu Leu  Thr Phe Phe Leu Lys  Gly Arg Asp Lys Leu  Ala Thr Phe 
    1115                 1120                 1125             


Pro Asn  Gly Pro Ser Val Thr  Leu Pro His Gln Val  Val Asp Asn 
    1130                 1135                 1140             


Ser 
    


<210>  17
<211>  1144
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn  Lys Glu Asp Lys Ser  Glu Arg Glu 
        995                 1000                 1005             


Arg Trp  Gln His Leu Ala Asp  Leu Ala Asp Phe Ala  Leu Ala Met 
    1010                 1015                 1020             


Lys Asp  Thr Leu Thr Asn Ile  Asn Asn Gln Ser Phe  Asn Asn Phe 
    1025                 1030                 1035             


Met Leu  Arg Ile Gly Met Asn  Lys Gly Gly Val Leu  Ala Gly Val 
    1040                 1045                 1050             


Ile Gly  Ala Arg Lys Pro His  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1055                 1060                 1065             


Asn Val  Ala Ser Arg Met Glu  Ser Thr Gly Val Met  Gly Asn Ile 
    1070                 1075                 1080             


Gln Val  Val Glu Glu Thr Gln  Val Ile Leu Arg Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Arg Phe  Val Arg Arg Gly Pro  Ile Phe Val Lys Gly  Lys Gly Glu 
    1100                 1105                 1110             


Leu Leu  Thr Phe Phe Leu Lys  Gly Arg Asp Lys Leu  Ala Thr Phe 
    1115                 1120                 1125             


Pro Asn  Gly Pro Ser Val Thr  Leu Pro His Gln Val  Val Asp Asn 
    1130                 1135                 1140             


Ser 
    


