                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> METHOD FOR GENERATING CELL-PENETRATING STAPLED PEPTIDES THAT LACK
      NONSPECIFIC MEMBRANE-LYTIC PROPERTIES FOR THERAPEUTIC TARGETING

<130> 00530-0327WO1

<140> PCT/US2017/019108
<141> 2017-02-23

<150> 62/298,931
<151> 2016-02-23

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 2
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S-pentenyl alanine

<400> 2
Ala Trp Ile Ala Ala Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 3
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> S-pentenyl alanine

<400> 3
Ile Ala Ile Ala Gln Ala Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 4
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> S-pentenyl alanine

<400> 4
Ile Trp Ala Ala Gln Glu Ala Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 5
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> S-pentenyl alanine

<400> 5
Ile Trp Ile Ala Gln Glu Leu Ala Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 6
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<400> 6
Ile Trp Ile Ala Ala Glu Leu Arg Ala Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 7
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> S-pentenyl alanine

<400> 7
Ile Trp Ile Ala Gln Ala Leu Arg Arg Ala Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 8
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> S-pentenyl alanine

<400> 8
Ile Trp Ile Ala Gln Glu Ala Arg Arg Ile Ala Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 9
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> S-pentenyl alanine

<400> 9
Ile Trp Ile Ala Gln Glu Leu Ala Arg Ile Gly Ala Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 10
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 10
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> S-pentenyl alanine

<400> 11
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ala Gly Asp Glu Ala Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> S-pentenyl alanine

<400> 12
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Ala Asp Glu Phe Ala Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (12)..(12)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S-pentenyl alanine

<400> 13
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Ala Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 14
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> S-pentenyl alanine

<400> 14
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Ala Tyr Ala Arg Arg 
            20      


<210> 15
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> S-pentenyl alanine

<400> 15
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Ala Asn Ala 
1               5                   10                  15      


Tyr Ala Ala Arg Arg 
            20      


<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (15)..(15)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> S-pentenyl alanine

<400> 16
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Ala Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 17
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (16)..(16)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> S-pentenyl alanine

<400> 17
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Ala Arg 
            20      


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> S-pentenyl alanine

<400> 18
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Ala Tyr Ala Arg Ala 
            20      


<210> 19
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 19
Ile Trp Ile Ala Leu Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 20
Ile Trp Ile Ala Gln Leu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 21
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 21
Ile Trp Ile Ala Gln Glu Leu Leu Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 22
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 22
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Leu Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 23
Ile Leu Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 24
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 24
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Leu 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 25
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 25
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Leu Tyr Ala Arg Arg 
            20      


<210> 26
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 26
Ile Glu Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 27
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 27
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Glu Tyr Ala Arg Arg 
            20      


<210> 28
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 28
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Arg 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 29
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 29
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Arg Tyr Ala Arg Arg 
            20      


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 30
Ile Trp Ile Ala Gln Glu Leu Asp Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 31
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 31
Ile Trp Ile Ala Gln Glu Leu Arg Ala Glu Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 32
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 32
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Thr Arg Arg 
            20      


<210> 33
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 33
Ile Arg Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 34
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 34
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Glu 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 35
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Phe Asn Ala 
1               5                   10                  15      


Thr Tyr Ala Arg Arg 
            20      


<210> 36
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 36
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Glu Asp Ala Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 37
Ile Trp Ile Ala Gln Glu Leu Arg Ala Ile Gly Asp Ala Val Asn Ala 
1               5                   10                  15      


Tyr Tyr Ala Arg Arg 
            20      


<210> 38
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> R-octenyl alanine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> S-pentenyl alanine

<400> 38
Leu Thr Phe Ala Glu Tyr Trp Ala Asn Ala Ala Ser Ala Ala 
1               5                   10                    


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
1               5                   10                  15      


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> S-pentenyl alanine

<400> 40
Ala Phe Gly Ile Tyr Leu Thr Ala Ile Leu Lys Thr Glu Glu Gly Asn 
1               5                   10                  15      


<210> 41
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> S-pentenyl alanine

<400> 41
Phe Ala Gly Ile Tyr Leu Thr Asn Ala Leu Lys Thr Glu Glu Gly Asn 
1               5                   10                  15      


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> S-pentenyl alanine

<400> 42
Phe Phe Ala Ile Tyr Leu Thr Asn Ile Ala Lys Thr Glu Glu Gly Asn 
1               5                   10                  15      


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> S-pentenyl alanine

<400> 43
Phe Phe Gly Ala Tyr Leu Thr Asn Ile Leu Ala Thr Glu Glu Gly Asn 
1               5                   10                  15      


<210> 44
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> S-pentenyl alanine

<400> 44
Phe Phe Gly Ile Ala Leu Thr Asn Ile Leu Lys Ala Glu Glu Gly Asn 
1               5                   10                  15      


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (13)..(13)
<223> S-pentenyl alanine

<400> 45
Phe Phe Gly Ile Tyr Ala Thr Asn Ile Leu Lys Thr Ala Glu Gly Asn 
1               5                   10                  15      


<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (14)..(14)
<223> S-pentenyl alanine

<400> 46
Phe Phe Gly Ile Tyr Leu Ala Asn Ile Leu Lys Thr Glu Ala Gly Asn 
1               5                   10                  15      


<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (15)..(15)
<223> S-pentenyl alanine

<400> 47
Phe Phe Gly Ile Tyr Leu Thr Ala Ile Leu Lys Thr Glu Glu Ala Asn 
1               5                   10                  15      


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S-pentenyl alanine

<400> 48
Phe Phe Gly Ile Tyr Leu Thr Asn Ala Leu Lys Thr Glu Glu Gly Ala 
1               5                   10                  15      


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> R-octenyl alanine 

<220>
<221> MOD_RES
<222> (17)..(17)
<223> S-pentenyl alanine

<400> 49
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Ala Lys Thr Glu Glu Gly Asn 
1               5                   10                  15      


Ala 
    


<210> 50
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Glu, Leu or Arg

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Leu or Asp

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Leu, Glu or Arg

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Thr, Glu, Leu or Arg

<400> 50
Ile Xaa Ile Ala Leu Glu Leu Xaa Arg Glu Glu Leu Glu Val Asn Xaa 
1               5                   10                  15      


Xaa Tyr Thr Arg Arg 
            20      


<210> 51
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Leu, Glu or Arg

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Leu or Asp 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Leu, Glu or Arg

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Thr, Glu, Arg or Leu 

<400> 51
Ile Xaa Ile Ala Leu Leu Leu Xaa Arg Glu Glu Leu Glu Val Asn Xaa 
1               5                   10                  15      


Xaa Tyr Thr Arg Arg 
            20      


