                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  PACKAGING CELL

<130>  P108339PCT

<150>  GB 1603374.8
<151>  2016-02-26

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  11581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sindbis plasmid (987SinRep) base pair sequence

<400>  1
ctgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga       60

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg      120

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat      180

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg      240

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata      300

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt      360

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat      420

ttaacgcgaa ttttaacaaa atattaacgc ttacaatttc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgaat tgtaatacga ctcactatag ggcgaattgg atccgaccgc      660

gaaggtcaat gccccgtaca ttcgcattcg agcacagcaa ctctccaaga gtcgacagta      720

catgtcctgg agaaaggagc ggtgacagta cactttagca ccgcgagtcc acaggcgaac      780

tttatcgtat cgctgtgtgg gctagtggat ccggagtctt atgcaatact cttgtagtct      840

tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca      900

tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt      960

ctgacatgga ttggacgaac cactgaattc cgcattgcag agatattgta tttaagtgcc     1020

tagctcgata ccgtcgagat tgacggcgta gtacacacta ttgaatcaaa cagccgacca     1080

attgcactac catcacaatg gagaagccag tagtaaacgt agacgtagac ccccagagtc     1140

cgtttgtcgt gcaactgcaa aaaagcttcc cgcaatttga ggtagtagca cagcaggtca     1200

ctccaaatga ccatgctaat gccagagcat tttcgcatct ggccagtaaa ctaatcgagc     1260

tggaggttcc taccacagcg acgatcttgg acataggcag cgcaccggct cgtagaatgt     1320

tttccgagca ccagtatcat tgtgtctgcc ccatgcgtag tccagaagac ccggaccgca     1380

tgatgaaata tgccagtaaa ctggcggaaa aagcgtgcaa gattacaaac aagaacttgc     1440

atgagaagat taaggatctc cggaccgtac ttgatacgcc ggatgctgaa acaccatcgc     1500

tctgctttca caacgatgtt acctgcaaca tgcgtgccga atattccgtc atgcaggacg     1560

tgtatatcaa cgctcccgga actatctatc atcaggctat gaaaggcgtg cggaccctgt     1620

actggattgg cttcgacacc acccagttca tgttctcggc tatggcaggt tcgtaccctg     1680

cgtacaacac caactgggcc gacgagaaag tccttgaagc gcgtaacatc ggactttgca     1740

gcacaaagct gagtgaaggt aggacaggaa aattgtcgat aatgaggaag aaggagttga     1800

agcccgggtc gcgggtttat ttctccgtag gatcgacact ttatccagaa cacagagcca     1860

gcttgcagag ctggcatctt ccatcggtgt tccacttgaa tggaaagcag tcgtacactt     1920

gccgctgtga tacagtggtg agttgcgaag gctacgtagt gaagaaaatc accatcagtc     1980

ccgggatcac gggagaaacc gtgggatacg cggttacaca caatagcgag ggcttcttgc     2040

tatgcaaagt tactgacaca gtaaaaggag aacgggtatc gttccctgtg tgcacgtaca     2100

tcccggccac catatgcgat cagatgactg gtataatggc cacggatata tcacctgacg     2160

atgcacaaaa acttctggtt gggctcaacc agcgaattgt cattaacggt aggactaaca     2220

ggaacaccaa caccatgcaa aattaccttc tgccgatcat agcacaaggg ttcagcaaat     2280

gggctaagga gcgcaaggat gatcttgata acgagaaaat gctgggtact agagaacgca     2340

agcttacgta tggctgcttg tgggcgtttc gcactaagaa agtacattcg ttttatcgcc     2400

cacctggaac gcagacctgc gtaaaagtcc cagcctcttt tagcgctttt cccatgtcgt     2460

ccgtatggac gacctctttg cccatgtcgc tgaggcagaa attgaaactg gcattgcaac     2520

caaagaagga ggaaaaactg ctgcaggtct cggaggaatt agtcatggag gccaaggctg     2580

cttttgagga tgctcaggag gaagccagag cggagaagct ccgagaagca cttccaccat     2640

tagtggcaga caaaggcatc gaggcagccg cagaagttgt ctgcgaagtg gaggggctcc     2700

aggcggacat cggagcagca ttagttgaaa ccccgcgcgg tcacgtaagg ataatacctc     2760

aagcaaatga ccgtatgatc ggacagtata tcgttgtctc gccaaactct gtgctgaaga     2820

atgccaaact cgcaccagcg cacccgctag cagatcaggt taagatcata acacactccg     2880

gaagatcagg aaggtacgcg gtcgaaccat acgacgctaa agtactgatg ccagcaggag     2940

gtgccgtacc atggccagaa ttcctagcac tgagtgagag cgccacgtta gtgtacaacg     3000

aaagagagtt tgtgaaccgc aaactatacc acattgccat gcatggcccc gccaagaata     3060

cagaagagga gcagtacaag gttacaaagg cagagcttgc agaaacagag tacgtgtttg     3120

acgtggacaa gaagcgttgc gttaagaagg aagaagcctc aggtctggtc ctctcgggag     3180

aactgaccaa ccctccctat catgagctag ctctggaggg actgaagacc cgacctgcgg     3240

tcccgtacaa ggtcgaaaca ataggagtga taggcacacc ggggtcgggc aagtcagcta     3300

ttatcaagtc aactgtcacg gcacgagatc ttgttaccag cggaaagaaa gaaaattgtc     3360

gcgaaattga ggccgacgtg ctaagactga ggggtatgca gattacgtcg aagacagtag     3420

attcggttat gctcaacgga tgccacaaag ccgtagaagt gctgtacgtt gacgaagcgt     3480

tcgcgtgcca cgcaggagca ctacttgcct tgattgctat cgtcaggccc cgcaagaagg     3540

tagtactatg cggagacccc atgcaatgcg gattcttcaa catgatgcaa ctaaaggtac     3600

atttcaatca ccctgaaaaa gacatatgca ccaagacatt ctacaagtat atctcccggc     3660

gttgcacaca gccagttaca gctattgtat cgacactgca ttacgatgga aagatgaaaa     3720

ccacgaaccc gtgcaagaag aacattgaaa tcgatattac aggggccaca aagccgaagc     3780

caggggatat catcctgaca tgtttccgcg ggtgggttaa gcaattgcaa atcgactatc     3840

ccggacatga agtaatgaca gccgcggcct cacaagggct aaccagaaaa ggagtgtatg     3900

ccgtccggca aaaagtcaat gaaaacccac tgtacgcgat cacatcagag catgtgaacg     3960

tgttgctcac ccgcactgag gacaggctag tgtggaaaac cttgcagggc gacccatgga     4020

ttaagcagct cactaacata cctaaaggaa actttcaggc tactatagag gactgggaag     4080

ctgaacacaa gggaataatt gctgcaataa acagccccac tccccgtgcc aatccgttca     4140

gctgcaagac caacgtttgc tgggcgaaag cattggaacc gatactagcc acggccggta     4200

tcgtacttac cggttgccag tggagcgaac tgttcccaca gtttgcggat gacaaaccac     4260

attcggccat ttacgcctta gacgtaattt gcattaagtt tttcggcatg gacttgacaa     4320

gcggactgtt ttctaaacag agcatcccac taacgtacca tcccgccgat tcagcgaggc     4380

cggtagctca ttgggacaac agcccaggaa cccgcaagta tgggtacgat cacgccattg     4440

ccgccgaact ctcccgtaga tttccggtgt tccagctagc tgggaagggc acacaacttg     4500

atttgcagac ggggagaacc agagttatct ctgcacagca taacctggtc ccggtgaacc     4560

gcaatcttcc tcacgcctta gtccccgagt acaaggagaa gcaacccggc ccggtcgaaa     4620

aattcttgaa ccagttcaaa caccactcag tacttgtggt atcagaggaa aaaattgaag     4680

ctccccgtaa gagaatcgaa tggatcgccc cgattggcat agccggtgca gataagaact     4740

acaacctggc tttcgggttt ccgccgcagg cacggtacga cctggtgttc atcaacattg     4800

gaactaaata cagaaaccac cactttcagc agtgcgaaga ccatgcggcg accttaaaaa     4860

ccctttcgcg ttcggccctg aattgcctta acccaggagg caccctcgtg gtgaagtcct     4920

atggctacgc cgaccgcaac agtgaggacg tagtcaccgc tcttgccaga aagtttgtca     4980

gggtgtctgc agcgagacca gattgtgtct caagcaatac agaaatgtac ctgattttcc     5040

gacaactaga caacagccgt acacggcaat tcaccccgca ccatctgaat tgcgtgattt     5100

cgtccgtgta tgagggtaca agagatggag ttggagccgc gccgtcatac cgcaccaaaa     5160

gggagaatat tgctgactgt caagaggaag cagttgtcaa cgcagccaat ccgctgggta     5220

gaccaggcga aggagtctgc cgtgccatct ataaacgttg gccgaccagt tttaccgatt     5280

cagccacgga gacaggcacc gcaagaatga ctgtgtgcct aggaaagaaa gtgatccacg     5340

cggtcggccc tgatttccgg aagcacccag aagcagaagc cttgaaattg ctacaaaacg     5400

cctaccatgc agtggcagac ttagtaaatg aacataacat caagtctgtc gccattccac     5460

tgctatctac aggcatttac gcagccggaa aagaccgcct tgaagtatca cttaactgct     5520

tgacaaccgc gctagacaga actgacgcgg acgtaaccat ctattgcctg gataagaagt     5580

ggaaggaaag aatcgacgcg gcactccaac ttaaggagtc tgtaacagag ctgaaggatg     5640

aagatatgga gatcgacgat gagttagtat ggattcatcc agacagttgc ttgaagggaa     5700

gaaagggatt cagtactaca aaaggaaaat tgtattcgta cttcgaaggc accaaattcc     5760

atcaagcagc aaaagacatg gcggagataa aggtcctgtt ccctaatgac caggaaagta     5820

atgaacaact gtgtgcctac atattgggtg agaccatgga agcaatccgc gaaaagtgcc     5880

cggtcgacca taacccgtcg tctagcccgc ccaaaacgtt gccgtgcctt tgcatgtatg     5940

ccatgacgcc agaaagggtc cacagactta gaagcaataa cgtcaaagaa gttacagtat     6000

gctcctccac cccccttcct aagcacaaaa ttaagaatgt tcagaaggtt cagtgcacga     6060

aagtagtcct gtttaatccg cacactcccg cattcgttcc cgcccgtaag tacatagaag     6120

tgccagaaca gcctaccgct cctcctgcac aggccgagga ggcccccgaa gttgtagcga     6180

caccgtcacc atctacagct gataacacct cgcttgatgt cacagacatc tcactggata     6240

tggatgacag tagcgaaggc tcactttttt cgagctttag cggatcggac aactctatta     6300

ctagtatgga cagttggtcg tcaggaccta gttcactaga gatagtagac cgaaggcagg     6360

tggtggtggc tgacgttcat gccgtccaag agcctgcccc tattccaccg ccaaggctaa     6420

agaagatggc ccgcctggca gcggcaagaa aagagcccac tccaccggca agcaatagct     6480

ctgagtccct ccacctctct tttggtgggg tatccatgtc cctcggatca attttcgacg     6540

gagagacggc ccgccaggca gcggtacaac ccctggcaac aggccccacg gatgtgccta     6600

tgtctttcgg atcgttttcc gacggagaga ttgatgagct gagccgcaga gtaactgagt     6660

ccgaacccgt cctgtttgga tcatttgaac cgggcgaagt gaactcaatt atatcgtccc     6720

gatcagccgt atcttttcct ctacgcaagc agagacgtag acgcaggagc aggaggactg     6780

aatactgact aaccggggta ggtgggtaca tattttcgac ggacacaggc cctgggcact     6840

tgcaaaagaa gtccgttctg cagaaccagc ttacagaacc gaccttggag cgcaatgtcc     6900

tggaaagaat tcatgccccg gtgctcgaca cgtcgaaaga ggaacaactc aaactcaggt     6960

accagatgat gcccaccgaa gccaacaaaa gtaggtacca gtctcgtaaa gtagaaaatc     7020

agaaagccat aaccactgag cgactactgt caggactacg actgtataac tctgccacag     7080

atcagccaga atgctataag atcacctatc cgaaaccatt gtactccagt agcgtaccgg     7140

cgaactactc cgatccacag ttcgctgtag ctgtctgtaa caactatctg catgagaact     7200

atccgacagt agcatcttat cagattactg acgagtacga tgcttacttg gatatggtag     7260

acgggacagt cgcctgcctg gatactgcaa ccttctgccc cgctaagctt agaagttacc     7320

cgaaaaaaca tgagtataga gccccgaata tccgcagtgc ggttccatca gcgatgcaga     7380

acacgctaca aaatgtgctc attgccgcaa ctaaaagaaa ttgcaacgtc acgcagatgc     7440

gtgaactgcc aacactggac tcagcgacat tcaatgtcga atgctttcga aaatatgcat     7500

gtaatgacga gtattgggag gagttcgctc ggaagccaat taggattacc actgagtttg     7560

tcaccgcata tgtagctaga ctgaaaggcc ctaaggccgc cgcactattt gcaaagacgt     7620

ataatttggt cccattgcaa gaagtgccta tggatagatt cgtcatggac atgaaaagag     7680

acgtgaaagt tacaccaggc acgaaacaca cagaagaaag accgaaagta caagtgatac     7740

aagccgcaga acccctggcg actgcttact tatgcgggat tcaccgggaa ttagtgcgta     7800

ggcttacggc cgtcttgctt ccaaacattc acacgctttt tgacatgtcg gcggaggatt     7860

ttgatgcaat catagcagaa cacttcaagc aaggcgaccc ggtactggag acggatatcg     7920

catcattcga caaaagccaa gacgacgcta tggcgttaac cggtctgatg atcttggagg     7980

acctgggtgt ggatcaacca ctactcgact tgatcgagtg cgcctttgga gaaatatcat     8040

ccacccatct acctacgggt actcgtttta aattcggggc gatgatgaaa tccggaatgt     8100

tcctcacact ttttgtcaac acagttttga atgtcgttat cgccagcaga gtactagaag     8160

agcggcttaa aacgtccaga tgtgcagcgt tcattggcga cgacaacatc atacatggag     8220

tagtatctga caaagaaatg gctgagaggt gcgccacctg gctcaacatg gaggttaaga     8280

tcatcgacgc agtcatcggt gagagaccac cttacttctg cggcggattt atcttgcaag     8340

attcggttac ttccacagcg tgccgcgtgg cggatcccct gaaaaggctg tttaagttgg     8400

gtaaaccgct cccagccgac gacgagcaag acgaagacag aagacgcgct ctgctagatg     8460

aaacaaaggc gtggtttaga gtaggtataa caggcacttt agcagtggcc gtgacgaccc     8520

ggtatgaggt agacaatatt acacctgtcc tactggcatt gagaactttt gcccagagca     8580

aaagagcatt ccaagccatc agaggggaaa taaagcatct ctacggtggt cctaaatagt     8640

cagcatagta catttcatct gactaatact acaacaccac cacctctaga ccgcgccgtt     8700

cgctaccatt accagttggt ctggtgtcaa aaataataat aaccgggcag gggggatcct     8760

agacgctacg ccccaatgat ccgaccagca aaactcgatg tacttccgag gaactgatgt     8820

gcataatgca ggaattcgat atcaagctag atctcacgtg agcatgcagg ccttgggccc     8880

aatgatccga ccagcaaaac tcgatgtact tccgaggaac tgatgtgcat aatgcatcag     8940

gctggtacat tagatccccg cttaccgcgg gcaatatagc aacactaaaa actcgatgta     9000

cttccgagga agcgcagtgc ataatgctgc gcagtgttgc cacataacca ctatattaac     9060

catttatcta gcggacgcca aaaactcaat gtatttctga ggaagcgtgg tgcataatgc     9120

cacgcagcgt ctgcataact tttattattt cttttattaa tcaacaaaat tttgttttta     9180

acatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaagggaat tcccaacttg     9240

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     9300

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     9360

gtctggatcc gtcgagacgc gtccaattcg ccctatagtg agtcgtatta cgcgcgcttg     9420

gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac     9480

aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc     9540

acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg     9600

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     9660

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     9720

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     9780

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     9840

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     9900

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     9960

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg    10020

ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg    10080

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt    10140

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg    10200

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac    10260

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga    10320

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt    10380

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt    10440

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga    10500

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc    10560

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct    10620

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata    10680

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca    10740

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga    10800

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga    10860

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg    10920

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga    10980

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt    11040

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct    11100

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca    11160

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat    11220

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga    11280

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc    11340

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg    11400

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc    11460

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt    11520

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca    11580

c                                                                    11581


<210>  2
<211>  2512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  987.SinRep amino acid sequence with P726S (non-cytotoxic) and 
       G153E (RdRp-temprature-regulated) mutations

<400>  2

Met Glu Lys Pro Val Val Asn Val Asp Val Asp Pro Gln Ser Pro Phe 
1               5                   10                  15      


Val Val Gln Leu Gln Lys Ser Phe Pro Gln Phe Glu Val Val Ala Gln 
            20                  25                  30          


Gln Val Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu 
        35                  40                  45              


Ala Ser Lys Leu Ile Glu Leu Glu Val Pro Thr Thr Ala Thr Ile Leu 
    50                  55                  60                  


Asp Ile Gly Ser Ala Pro Ala Arg Arg Met Phe Ser Glu His Gln Tyr 
65                  70                  75                  80  


His Cys Val Cys Pro Met Arg Ser Pro Glu Asp Pro Asp Arg Met Met 
                85                  90                  95      


Lys Tyr Ala Ser Lys Leu Ala Glu Lys Ala Cys Lys Ile Thr Asn Lys 
            100                 105                 110         


Asn Leu His Glu Lys Ile Lys Asp Leu Arg Thr Val Leu Asp Thr Pro 
        115                 120                 125             


Asp Ala Glu Thr Pro Ser Leu Cys Phe His Asn Asp Val Thr Cys Asn 
    130                 135                 140                 


Met Arg Ala Glu Tyr Ser Val Met Gln Asp Val Tyr Ile Asn Ala Pro 
145                 150                 155                 160 


Gly Thr Ile Tyr His Gln Ala Met Lys Gly Val Arg Thr Leu Tyr Trp 
                165                 170                 175     


Ile Gly Phe Asp Thr Thr Gln Phe Met Phe Ser Ala Met Ala Gly Ser 
            180                 185                 190         


Tyr Pro Ala Tyr Asn Thr Asn Trp Ala Asp Glu Lys Val Leu Glu Ala 
        195                 200                 205             


Arg Asn Ile Gly Leu Cys Ser Thr Lys Leu Ser Glu Gly Arg Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Met Arg Lys Lys Glu Leu Lys Pro Gly Ser Arg Val 
225                 230                 235                 240 


Tyr Phe Ser Val Gly Ser Thr Leu Tyr Pro Glu His Arg Ala Ser Leu 
                245                 250                 255     


Gln Ser Trp His Leu Pro Ser Val Phe His Leu Asn Gly Lys Gln Ser 
            260                 265                 270         


Tyr Thr Cys Arg Cys Asp Thr Val Val Ser Cys Glu Gly Tyr Val Val 
        275                 280                 285             


Lys Lys Ile Thr Ile Ser Pro Gly Ile Thr Gly Glu Thr Val Gly Tyr 
    290                 295                 300                 


Ala Val Thr His Asn Ser Glu Gly Phe Leu Leu Cys Lys Val Thr Asp 
305                 310                 315                 320 


Thr Val Lys Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Ile Pro 
                325                 330                 335     


Ala Thr Ile Cys Asp Gln Met Thr Gly Ile Met Ala Thr Asp Ile Ser 
            340                 345                 350         


Pro Asp Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val 
        355                 360                 365             


Ile Asn Gly Arg Thr Asn Arg Asn Thr Asn Thr Met Gln Asn Tyr Leu 
    370                 375                 380                 


Leu Pro Ile Ile Ala Gln Gly Phe Ser Lys Trp Ala Lys Glu Arg Lys 
385                 390                 395                 400 


Asp Asp Leu Asp Asn Glu Lys Met Leu Gly Thr Arg Glu Arg Lys Leu 
                405                 410                 415     


Thr Tyr Gly Cys Leu Trp Ala Phe Arg Thr Lys Lys Val His Ser Phe 
            420                 425                 430         


Tyr Arg Pro Pro Gly Thr Gln Thr Cys Val Lys Val Pro Ala Ser Phe 
        435                 440                 445             


Ser Ala Phe Pro Met Ser Ser Val Trp Thr Thr Ser Leu Pro Met Ser 
    450                 455                 460                 


Leu Arg Gln Lys Leu Lys Leu Ala Leu Gln Pro Lys Lys Glu Glu Lys 
465                 470                 475                 480 


Leu Leu Gln Val Ser Glu Glu Leu Val Met Glu Ala Lys Ala Ala Phe 
                485                 490                 495     


Glu Asp Ala Gln Glu Glu Ala Arg Ala Glu Lys Leu Arg Glu Ala Leu 
            500                 505                 510         


Pro Pro Leu Val Ala Asp Lys Gly Ile Glu Ala Ala Ala Glu Val Val 
        515                 520                 525             


Cys Glu Val Glu Gly Leu Gln Ala Asp Ile Gly Ala Ala Leu Val Glu 
    530                 535                 540                 


Thr Pro Arg Gly His Val Arg Ile Ile Pro Gln Ala Asn Asp Arg Met 
545                 550                 555                 560 


Ile Gly Gln Tyr Ile Val Val Ser Pro Asn Ser Val Leu Lys Asn Ala 
                565                 570                 575     


Lys Leu Ala Pro Ala His Pro Leu Ala Asp Gln Val Lys Ile Ile Thr 
            580                 585                 590         


His Ser Gly Arg Ser Gly Arg Tyr Ala Val Glu Pro Tyr Asp Ala Lys 
        595                 600                 605             


Val Leu Met Pro Ala Gly Gly Ala Val Pro Trp Pro Glu Phe Leu Ala 
    610                 615                 620                 


Leu Ser Glu Ser Ala Thr Leu Val Tyr Asn Glu Arg Glu Phe Val Asn 
625                 630                 635                 640 


Arg Lys Leu Tyr His Ile Ala Met His Gly Pro Ala Lys Asn Thr Glu 
                645                 650                 655     


Glu Glu Gln Tyr Lys Val Thr Lys Ala Glu Leu Ala Glu Thr Glu Tyr 
            660                 665                 670         


Val Phe Asp Val Asp Lys Lys Arg Cys Val Lys Lys Glu Glu Ala Ser 
        675                 680                 685             


Gly Leu Val Leu Ser Gly Glu Leu Thr Asn Pro Pro Tyr His Glu Leu 
    690                 695                 700                 


Ala Leu Glu Gly Leu Lys Thr Arg Pro Ala Val Pro Tyr Lys Val Glu 
705                 710                 715                 720 


Thr Ile Gly Val Ile Gly Thr Pro Gly Ser Gly Lys Ser Ala Ile Ile 
                725                 730                 735     


Lys Ser Thr Val Thr Ala Arg Asp Leu Val Thr Ser Gly Lys Lys Glu 
            740                 745                 750         


Asn Cys Arg Glu Ile Glu Ala Asp Val Leu Arg Leu Arg Gly Met Gln 
        755                 760                 765             


Ile Thr Ser Lys Thr Val Asp Ser Val Met Leu Asn Gly Cys His Lys 
    770                 775                 780                 


Ala Val Glu Val Leu Tyr Val Asp Glu Ala Phe Ala Cys His Ala Gly 
785                 790                 795                 800 


Ala Leu Leu Ala Leu Ile Ala Ile Val Arg Pro Arg Lys Lys Val Val 
                805                 810                 815     


Leu Cys Gly Asp Pro Met Gln Cys Gly Phe Phe Asn Met Met Gln Leu 
            820                 825                 830         


Lys Val His Phe Asn His Pro Glu Lys Asp Ile Cys Thr Lys Thr Phe 
        835                 840                 845             


Tyr Lys Tyr Ile Ser Arg Arg Cys Thr Gln Pro Val Thr Ala Ile Val 
    850                 855                 860                 


Ser Thr Leu His Tyr Asp Gly Lys Met Lys Thr Thr Asn Pro Cys Lys 
865                 870                 875                 880 


Lys Asn Ile Glu Ile Asp Ile Thr Gly Ala Thr Lys Pro Lys Pro Gly 
                885                 890                 895     


Asp Ile Ile Leu Thr Cys Phe Arg Gly Trp Val Lys Gln Leu Gln Ile 
            900                 905                 910         


Asp Tyr Pro Gly His Glu Val Met Thr Ala Ala Ala Ser Gln Gly Leu 
        915                 920                 925             


Thr Arg Lys Gly Val Tyr Ala Val Arg Gln Lys Val Asn Glu Asn Pro 
    930                 935                 940                 


Leu Tyr Ala Ile Thr Ser Glu His Val Asn Val Leu Leu Thr Arg Thr 
945                 950                 955                 960 


Glu Asp Arg Leu Val Trp Lys Thr Leu Gln Gly Asp Pro Trp Ile Lys 
                965                 970                 975     


Gln Leu Thr Asn Ile Pro Lys Gly Asn Phe Gln Ala Thr Ile Glu Asp 
            980                 985                 990         


Trp Glu Ala Glu His Lys Gly Ile  Ile Ala Ala Ile Asn  Ser Pro Thr 
        995                 1000                 1005             


Pro Arg  Ala Asn Pro Phe Ser  Cys Lys Thr Asn Val  Cys Trp Ala 
    1010                 1015                 1020             


Lys Ala  Leu Glu Pro Ile Leu  Ala Thr Ala Gly Ile  Val Leu Thr 
    1025                 1030                 1035             


Gly Cys  Gln Trp Ser Glu Leu  Phe Pro Gln Phe Ala  Asp Asp Lys 
    1040                 1045                 1050             


Pro His  Ser Ala Ile Tyr Ala  Leu Asp Val Ile Cys  Ile Lys Phe 
    1055                 1060                 1065             


Phe Gly  Met Asp Leu Thr Ser  Gly Leu Phe Ser Lys  Gln Ser Ile 
    1070                 1075                 1080             


Pro Leu  Thr Tyr His Pro Ala  Asp Ser Ala Arg Pro  Val Ala His 
    1085                 1090                 1095             


Trp Asp  Asn Ser Pro Gly Thr  Arg Lys Tyr Gly Tyr  Asp His Ala 
    1100                 1105                 1110             


Ile Ala  Ala Glu Leu Ser Arg  Arg Phe Pro Val Phe  Gln Leu Ala 
    1115                 1120                 1125             


Gly Lys  Gly Thr Gln Leu Asp  Leu Gln Thr Gly Arg  Thr Arg Val 
    1130                 1135                 1140             


Ile Ser  Ala Gln His Asn Leu  Val Pro Val Asn Arg  Asn Leu Pro 
    1145                 1150                 1155             


His Ala  Leu Val Pro Glu Tyr  Lys Glu Lys Gln Pro  Gly Pro Val 
    1160                 1165                 1170             


Glu Lys  Phe Leu Asn Gln Phe  Lys His His Ser Val  Leu Val Val 
    1175                 1180                 1185             


Ser Glu  Glu Lys Ile Glu Ala  Pro Arg Lys Arg Ile  Glu Trp Ile 
    1190                 1195                 1200             


Ala Pro  Ile Gly Ile Ala Gly  Ala Asp Lys Asn Tyr  Asn Leu Ala 
    1205                 1210                 1215             


Phe Gly  Phe Pro Pro Gln Ala  Arg Tyr Asp Leu Val  Phe Ile Asn 
    1220                 1225                 1230             


Ile Gly  Thr Lys Tyr Arg Asn  His His Phe Gln Gln  Cys Glu Asp 
    1235                 1240                 1245             


His Ala  Ala Thr Leu Lys Thr  Leu Ser Arg Ser Ala  Leu Asn Cys 
    1250                 1255                 1260             


Leu Asn  Ser Gly Gly Thr Leu  Val Val Lys Ser Tyr  Gly Tyr Ala 
    1265                 1270                 1275             


Asp Arg  Asn Ser Glu Asp Val  Val Thr Ala Leu Ala  Arg Lys Phe 
    1280                 1285                 1290             


Val Arg  Val Ser Ala Ala Arg  Pro Asp Cys Val Ser  Ser Asn Thr 
    1295                 1300                 1305             


Glu Met  Tyr Leu Ile Phe Arg  Gln Leu Asp Asn Ser  Arg Thr Arg 
    1310                 1315                 1320             


Gln Phe  Thr Pro His His Leu  Asn Cys Val Ile Ser  Ser Val Tyr 
    1325                 1330                 1335             


Glu Gly  Thr Arg Asp Gly Val  Gly Ala Ala Pro Ser  Tyr Arg Thr 
    1340                 1345                 1350             


Lys Arg  Glu Asn Ile Ala Asp  Cys Gln Glu Glu Ala  Val Val Asn 
    1355                 1360                 1365             


Ala Ala  Asn Pro Leu Gly Arg  Pro Gly Glu Gly Val  Cys Arg Ala 
    1370                 1375                 1380             


Ile Tyr  Lys Arg Trp Pro Thr  Ser Phe Thr Asp Ser  Ala Thr Glu 
    1385                 1390                 1395             


Thr Gly  Thr Ala Arg Met Thr  Val Cys Leu Gly Lys  Lys Val Ile 
    1400                 1405                 1410             


His Ala  Val Gly Pro Asp Phe  Arg Lys His Pro Glu  Ala Glu Ala 
    1415                 1420                 1425             


Leu Lys  Leu Leu Gln Asn Ala  Tyr His Ala Val Ala  Asp Leu Val 
    1430                 1435                 1440             


Asn Glu  His Asn Ile Lys Ser  Val Ala Ile Pro Leu  Leu Ser Thr 
    1445                 1450                 1455             


Gly Ile  Tyr Ala Ala Gly Lys  Asp Arg Leu Glu Val  Ser Leu Asn 
    1460                 1465                 1470             


Cys Leu  Thr Thr Ala Leu Asp  Arg Thr Asp Ala Asp  Val Thr Ile 
    1475                 1480                 1485             


Tyr Cys  Leu Asp Lys Lys Trp  Lys Glu Arg Ile Asp  Ala Ala Leu 
    1490                 1495                 1500             


Gln Leu  Lys Glu Ser Val Thr  Glu Leu Lys Asp Glu  Asp Met Glu 
    1505                 1510                 1515             


Ile Asp  Asp Glu Leu Val Trp  Ile His Pro Asp Ser  Cys Leu Lys 
    1520                 1525                 1530             


Gly Arg  Lys Gly Phe Ser Thr  Thr Lys Gly Lys Leu  Tyr Ser Tyr 
    1535                 1540                 1545             


Phe Glu  Gly Thr Lys Phe His  Gln Ala Ala Lys Asp  Met Ala Glu 
    1550                 1555                 1560             


Ile Lys  Val Leu Phe Pro Asn  Asp Gln Glu Ser Asn  Glu Gln Leu 
    1565                 1570                 1575             


Cys Ala  Tyr Ile Leu Gly Glu  Thr Met Glu Ala Ile  Arg Glu Lys 
    1580                 1585                 1590             


Cys Pro  Val Asp His Asn Pro  Ser Ser Ser Pro Pro  Lys Thr Leu 
    1595                 1600                 1605             


Pro Cys  Leu Cys Met Tyr Ala  Met Thr Pro Glu Arg  Val His Arg 
    1610                 1615                 1620             


Leu Arg  Ser Asn Asn Val Lys  Glu Val Thr Val Cys  Ser Ser Thr 
    1625                 1630                 1635             


Pro Leu  Pro Lys His Lys Ile  Lys Asn Val Gln Lys  Val Gln Cys 
    1640                 1645                 1650             


Thr Lys  Val Val Leu Phe Asn  Pro His Thr Pro Ala  Phe Val Pro 
    1655                 1660                 1665             


Ala Arg  Lys Tyr Ile Glu Val  Pro Glu Gln Pro Thr  Ala Pro Pro 
    1670                 1675                 1680             


Ala Gln  Ala Glu Glu Ala Pro  Glu Val Val Ala Thr  Pro Ser Pro 
    1685                 1690                 1695             


Ser Thr  Ala Asp Asn Thr Ser  Leu Asp Val Thr Asp  Ile Ser Leu 
    1700                 1705                 1710             


Asp Met  Asp Asp Ser Ser Glu  Gly Ser Leu Phe Ser  Ser Phe Ser 
    1715                 1720                 1725             


Gly Ser  Asp Asn Ser Ile Thr  Ser Met Asp Ser Trp  Ser Ser Gly 
    1730                 1735                 1740             


Pro Ser  Ser Leu Glu Ile Val  Asp Arg Arg Gln Val  Val Val Ala 
    1745                 1750                 1755             


Asp Val  His Ala Val Gln Glu  Pro Ala Pro Ile Pro  Pro Pro Arg 
    1760                 1765                 1770             


Leu Lys  Lys Met Ala Arg Leu  Ala Ala Ala Arg Lys  Glu Pro Thr 
    1775                 1780                 1785             


Pro Pro  Ala Ser Asn Ser Ser  Glu Ser Leu His Leu  Ser Phe Gly 
    1790                 1795                 1800             


Gly Val  Ser Met Ser Leu Gly  Ser Ile Phe Asp Gly  Glu Thr Ala 
    1805                 1810                 1815             


Arg Gln  Ala Ala Val Gln Pro  Leu Ala Thr Gly Pro  Thr Asp Val 
    1820                 1825                 1830             


Pro Met  Ser Phe Gly Ser Phe  Ser Asp Gly Glu Ile  Asp Glu Leu 
    1835                 1840                 1845             


Ser Arg  Arg Val Thr Glu Ser  Glu Pro Val Leu Phe  Gly Ser Phe 
    1850                 1855                 1860             


Glu Pro  Gly Glu Val Asn Ser  Ile Ile Ser Ser Arg  Ser Ala Val 
    1865                 1870                 1875             


Ser Phe  Pro Leu Arg Lys Gln  Arg Arg Arg Arg Arg  Ser Arg Arg 
    1880                 1885                 1890             


Thr Glu  Tyr Leu Thr Gly Val  Gly Gly Tyr Ile Phe  Ser Thr Asp 
    1895                 1900                 1905             


Thr Gly  Pro Gly His Leu Gln  Lys Lys Ser Val Leu  Gln Asn Gln 
    1910                 1915                 1920             


Leu Thr  Glu Pro Thr Leu Glu  Arg Asn Val Leu Glu  Arg Ile His 
    1925                 1930                 1935             


Ala Pro  Val Leu Asp Thr Ser  Lys Glu Glu Gln Leu  Lys Leu Arg 
    1940                 1945                 1950             


Tyr Gln  Met Met Pro Thr Glu  Ala Asn Lys Ser Arg  Tyr Gln Ser 
    1955                 1960                 1965             


Arg Lys  Val Glu Asn Gln Lys  Ala Ile Thr Thr Glu  Arg Leu Leu 
    1970                 1975                 1980             


Ser Gly  Leu Arg Leu Tyr Asn  Ser Ala Thr Asp Gln  Pro Glu Cys 
    1985                 1990                 1995             


Tyr Lys  Ile Thr Tyr Pro Lys  Pro Leu Tyr Ser Ser  Ser Val Pro 
    2000                 2005                 2010             


Ala Asn  Tyr Ser Asp Pro Gln  Phe Ala Val Ala Val  Cys Asn Asn 
    2015                 2020                 2025             


Tyr Leu  His Glu Asn Tyr Pro  Thr Val Ala Ser Tyr  Gln Ile Thr 
    2030                 2035                 2040             


Asp Glu  Tyr Asp Ala Tyr Leu  Asp Met Val Asp Glu  Thr Val Ala 
    2045                 2050                 2055             


Cys Leu  Asp Thr Ala Thr Phe  Cys Pro Ala Lys Leu  Arg Ser Tyr 
    2060                 2065                 2070             


Pro Lys  Lys His Glu Tyr Arg  Ala Pro Asn Ile Arg  Ser Ala Val 
    2075                 2080                 2085             


Pro Ser  Ala Met Gln Asn Thr  Leu Gln Asn Val Leu  Ile Ala Ala 
    2090                 2095                 2100             


Thr Lys  Arg Asn Cys Asn Val  Thr Gln Met Arg Glu  Leu Pro Thr 
    2105                 2110                 2115             


Leu Asp  Ser Ala Thr Phe Asn  Val Glu Cys Phe Arg  Lys Tyr Ala 
    2120                 2125                 2130             


Cys Asn  Asp Glu Tyr Trp Glu  Glu Phe Ala Arg Lys  Pro Ile Arg 
    2135                 2140                 2145             


Ile Thr  Thr Glu Phe Val Thr  Ala Tyr Val Ala Arg  Leu Lys Gly 
    2150                 2155                 2160             


Pro Lys  Ala Ala Ala Leu Phe  Ala Lys Thr Tyr Asn  Leu Val Pro 
    2165                 2170                 2175             


Leu Gln  Glu Val Pro Met Asp  Arg Phe Val Met Asp  Met Lys Arg 
    2180                 2185                 2190             


Asp Val  Lys Val Thr Pro Gly  Thr Lys His Thr Glu  Glu Arg Pro 
    2195                 2200                 2205             


Lys Val  Gln Val Ile Gln Ala  Ala Glu Pro Leu Ala  Thr Ala Tyr 
    2210                 2215                 2220             


Leu Cys  Gly Ile His Arg Glu  Leu Val Arg Arg Leu  Thr Ala Val 
    2225                 2230                 2235             


Leu Leu  Pro Asn Ile His Thr  Leu Phe Asp Met Ser  Ala Glu Asp 
    2240                 2245                 2250             


Phe Asp  Ala Ile Ile Ala Glu  His Phe Lys Gln Gly  Asp Pro Val 
    2255                 2260                 2265             


Leu Glu  Thr Asp Ile Ala Ser  Phe Asp Lys Ser Gln  Asp Asp Ala 
    2270                 2275                 2280             


Met Ala  Leu Thr Gly Leu Met  Ile Leu Glu Asp Leu  Gly Val Asp 
    2285                 2290                 2295             


Gln Pro  Leu Leu Asp Leu Ile  Glu Cys Ala Phe Gly  Glu Ile Ser 
    2300                 2305                 2310             


Ser Thr  His Leu Pro Thr Gly  Thr Arg Phe Lys Phe  Gly Ala Met 
    2315                 2320                 2325             


Met Lys  Ser Gly Met Phe Leu  Thr Leu Phe Val Asn  Thr Val Leu 
    2330                 2335                 2340             


Asn Val  Val Ile Ala Ser Arg  Val Leu Glu Glu Arg  Leu Lys Thr 
    2345                 2350                 2355             


Ser Arg  Cys Ala Ala Phe Ile  Gly Asp Asp Asn Ile  Ile His Gly 
    2360                 2365                 2370             


Val Val  Ser Asp Lys Glu Met  Ala Glu Arg Cys Ala  Thr Trp Leu 
    2375                 2380                 2385             


Asn Met  Glu Val Lys Ile Ile  Asp Ala Val Ile Gly  Glu Arg Pro 
    2390                 2395                 2400             


Pro Tyr  Phe Cys Gly Gly Phe  Ile Leu Gln Asp Ser  Val Thr Ser 
    2405                 2410                 2415             


Thr Ala  Cys Arg Val Ala Asp  Pro Leu Lys Arg Leu  Phe Lys Leu 
    2420                 2425                 2430             


Gly Lys  Pro Leu Pro Ala Asp  Asp Glu Gln Asp Glu  Asp Arg Arg 
    2435                 2440                 2445             


Arg Ala  Leu Leu Asp Glu Thr  Lys Ala Trp Phe Arg  Val Gly Ile 
    2450                 2455                 2460             


Thr Gly  Thr Leu Ala Val Ala  Val Thr Thr Arg Tyr  Glu Val Asp 
    2465                 2470                 2475             


Asn Ile  Thr Pro Val Leu Leu  Ala Leu Arg Thr Phe  Ala Gln Ser 
    2480                 2485                 2490             


Lys Arg  Ala Phe Gln Ala Ile  Arg Gly Glu Ile Lys  His Leu Tyr 
    2495                 2500                 2505             


Gly Gly  Pro Lys 
    2510         


<210>  3
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eGFP amino acid sequence

<400>  3

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  4
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV-G  (glycoprotein G of the Vesicular stomatitis virus (VSV)) 
       amino acid sequence

<400>  4

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  5
<211>  4307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gag.Pol DNA sequence

<400>  5
atgggagcac gggctagtgt tctttctgga ggtgagcttg acaggtggga gaagatcaga       60

ctgcgccccg gcggcaaaaa gaagtacaag ctgaagcaca tcgtgtgggc ctctcgcgaa      120

ttggagaggt ttgccgtgaa ccccgggctc ctggagacaa gcgaggggtg ccggcagatc      180

ctcggccaat tgcagcccag tttgcaaacc ggcagcgagg agttgcggag cctgtacaac      240

accgtggcca cattgtactg cgtccaccag cgcatcgaaa tcaaggatac aaaagaggcc      300

ctggataaaa tcgaagagga acagaataag agcaaaaaga aggcccaaca agccgccgct      360

gataccggcc attctaacca agtgtctcag aactatccca tcgtccaaaa tattcaaggc      420

cagatggtcc accaagctat cagcccccgg accctgaacg cctgggtgaa ggtggtggag      480

gaaaaagcct tttctcccga ggtcatccct atgttcagcg ccctgagcga gggcgctaca      540

ccccaggacc tgaatacaat gttgaatacc gtcggcggcc accaggccgc tatgcagatg      600

ctgaaggaaa caattaacga agaggccgcc gagtgggacc gggtccaccc cgtccaggct      660

ggccccatcg cacccgggca aatgcgggag ccgagaggct ccgatatcgc cggcaccacc      720

tccacattgc aagagcagat cggctggatg accaacaatc ccccaattcc cgtgggcgag      780

atctacaagc ggtggatcat tctcggcctg aacaagatcg tgcggatgta ctctcccaca      840

tctatcctcg atatccggca gggccccaaa gagcctttcc gggattacgt ggatagattt      900

tacaagacct tgcgggctga acaggccagc caagaagtga agaactggat gacggagaca      960

ctcctcgtgc agaacgccaa tcccgactgc aaaaccatcc tgaaggcctt gggcccagcc     1020

gccaccttgg aggagatgat gaccgcctgc caaggcgtgg gaggccctgg gcacaaagcc     1080

cgggtgctcg ccgaggccat gtctcaggtg accaacagcg ccacaatcat gatgcaacgg     1140

gggaacttcc gcaatcagcg gaaaatcgtg aaatgcttta actgtggcaa agaagggcac     1200

acagcccgca actgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcagctc aaggaggctc tcctggccac cggagcagac gacaccgtgc     1560

tggaggagat gtcactccct ggtcggtgga agcctaagat gattggtggt atagggggct     1620

tcattaaggt gcggcaatac gaccaaatct tgatcgagat ttgcggccac aaggccatcg     1680

gcaccgtgct ggtgggcccc acccccgtga atatcatcgg ccggaacctc ctcacccaaa     1740

tcggctgtac cctgaacttc cctatctctc ccatcgaaac cgtgcccgtg aagctgaaac     1800

ccggcatgga cgggcccaag gtgaagcagt ggcccctcac cgaggagaag atcaaggccc     1860

tggtggagat ctgcaccgaa atggagaaag agggcaagat cagcaagatc ggccccgaga     1920

acccctataa cacccccgtg ttcgctatca aaaagaagga ttccaccaag tggcggaagc     1980

tggtggactt tcgggagttg aacaaacgga cccaggattt ttgggaggtg cagctgggca     2040

tcccccaccc tgccggcctg aagaaaaaga agagcgtgac cgtgctcgac gtcggcgacg     2100

cctacttcag cgtgcctctg gacgaggatt ttcgcaaata caccgccttc acaatcccct     2160

ccatcaataa cgaaaccccc ggcatccggt accaatataa cgtcttgccc caaggctgga     2220

agggcagccc cgccatcttt cagtcctcta tgaccaagat tctggaaccc ttccggaagc     2280

agaaccccga tatcgtgatt taccagtata tggacgacct ctacgtgggc agcgatctgg     2340

agatcggcca acaccggacc aagatcgaag aactccggca gcacctcctc cgctggggct     2400

tgacaacccc cgataagaag caccaaaagg agcctccctt tttgtggatg ggctacgagt     2460

tgcaccccga caagtggacc gtgcaaccca tcgtcctccc cgagaaggat tcttggaccg     2520

tgaacgatat ccaaaaactg gtcggcaagc tcaactgggc ctcccaaatc tatcccggca     2580

tcaaggtgcg ccagctgtgc aagttgttgc ggggcacaaa ggcgttgacc gaggtgatcc     2640

ccttgaccga ggaggccgaa ttggagctcg ccgagaatcg ggaaatcttg aaggagcccg     2700

tgcacggcgt ctactacgat cccagcaagg atctgatcgc cgagatccaa aaacaaggcc     2760

aggggcagtg gacctaccag atctaccagg aacccttcaa gaacctcaag accggcaagt     2820

acgcccggat gagaggcgcc cataccaacg acgtgaagca gctgaccgaa gccgtccaga     2880

agatcacaac cgagtctatc gtgatctggg gcaaaacccc caagttcaag ctccctatcc     2940

agaaggaaac gtgggaaacc tggtggaccg aatactggca ggctacatgg attcccgaat     3000

gggagttcgt gaacacaccc cctctggtca agctgtggta tcaactggaa aaggagccta     3060

tcgtgggcgc cgagacattt tacgtggacg gcgctgccaa tcgcgaaacc aagctgggca     3120

aggccggcta cgtgaccaat cggggccgcc agaaggtggt gacattgacc gataccacca     3180

accagaaaac cgaactgcag gccatctact tggccctcca agacagcggc ctggaggtga     3240

atatcgtgac cgatagccag tacgccctgg gcattatcca ggcccagccc gaccagtccg     3300

agagcgaact ggtgaaccag atcatcgaac aactgatcaa gaaagagaaa gtgtacctcg     3360

cctgggtgcc cgcccataag gggatcggcg gcaacgagca ggtggacaag ctggtgtccg     3420

ccggcattcg caaggtgttg ttcctggacg gcatcgacaa agctcaggac gagcacgaaa     3480

agtaccattc caactggcgg gccatggcct ccgacttcaa tttgccaccc gtggtggcca     3540

aggagatcgt ggcttcttgc gacaagtgcc aattgaaggg cgaggctatg cacggccagg     3600

tggattgctc ccccggcatc tggcagttgg actgcaccca cctggagggc aaggtgattc     3660

tcgtggccgt gcacgtggct tccggctaca tcgaggctga ggtgatcccg gccgaaaccg     3720

gccaagagac tgcctacttc ttgctgaagc tggccggcag gtggcccgta aagaccatcc     3780

acaccgataa cgggtctaac tttacatccg ccaccgtgaa agctgcttgc tggtgggcag     3840

gcattaaaca agagttcggc atcccttata accctcagtc ccagggcgtg gtggagagca     3900

tgaacaagga gctgaaaaag atcatcggcc aagtgcggga ccaagccgag cacttgaaaa     3960

ccgccgtgca gatggccgtg tttattcata acttcaagcg gaagggcggc atcggcggct     4020

attccgccgg tgagcggatc gtggatatca tcgccaccga tatccagacc aaggagctgc     4080

agaagcagat caccaagatc cagaacttca gagtgtacta tcgcgattct cggaacccct     4140

tgtggaaggg gccagccaaa ttgttgtgga agggggaggg cgccgtggtg atccaggaca     4200

actccgatat caaggtggtc ccgcggagga aggccaaaat tatccgcgac tacggcaagc     4260

aaatggccgg cgacgactgc gtcgcctccc ggcaagacga ggactga                   4307


<210>  6
<211>  5332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence which encodes nsp1234 of a Sindbis virus

<400>  6
ctgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga       60

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg      120

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat      180

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg      240

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata      300

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt      360

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat      420

ttaacgcgaa ttttaacaaa atattaacgc ttacaatttc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgaat tgtaatacga ctcactatag ggcgaattgg atccgaccgc      660

gaaggtcaat gccccgtaca ttcgcattcg agcacagcaa ctctccaaga gtcgacagta      720

catgtcctgg agaaaggagc ggtgacagta cactttagca ccgcgagtcc acaggcgaac      780

tttatcgtat cgctgtgtgg gctagtggat ccggagtctt atgcaatact cttgtagtct      840

tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca      900

tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt      960

ctgacatgga ttggacgaac cactgaattc cgcattgcag agatattgta tttaagtgcc     1020

tagctcgata ccgtcgagat tgacggcgta gtacacacta ttgaatcaaa cagccgacca     1080

attgcactac catcacaatg gagaagccag tagtaaacgt agacgtagac ccccagagtc     1140

cgtttgtcgt gcaactgcaa aaaagcttcc cgcaatttga ggtagtagca cagcaggtca     1200

ctccaaatga ccatgctaat gccagagcat tttcgcatct ggccagtaaa ctaatcgagc     1260

tggaggttcc taccacagcg acgatcttgg acataggcag cgcaccggct cgtagaatgt     1320

tttccgagca ccagtatcat tgtgtctgcc ccatgcgtag tccagaagac ccggaccgca     1380

tgatgaaata tgccagtaaa ctggcggaaa aagcgtgcaa gattacaaac aagaacttgc     1440

atgagaagat taaggatctc cggaccgtac ttgatacgcc ggatgctgaa acaccatcgc     1500

tctgctttca caacgatgtt acctgcaaca tgcgtgccga atattccgtc atgcaggacg     1560

tgtatatcaa cgctcccgga actatctatc atcaggctat gaaaggcgtg cggaccctgt     1620

actggattgg cttcgacacc acccagttca tgttctcggc tatggcaggt tcgtaccctg     1680

cgtacaacac caactgggcc gacgagaaag tccttgaagc gcgtaacatc ggactttgca     1740

gcacaaagct gagtgaaggt aggacaggaa aattgtcgat aatgaggaag aaggagttga     1800

agcccgggtc gcgggtttat ttctccgtag gatcgacact ttatccagaa cacagagcca     1860

gcttgcagag ctggcatctt ccatcggtgt tccacttgaa tggaaagcag tcgtacactt     1920

gccgctgtga tacagtggtg agttgcgaag gctacgtagt gaagaaaatc accatcagtc     1980

ccgggatcac gggagaaacc gtgggatacg cggttacaca caatagcgag ggcttcttgc     2040

tatgcaaagt tactgacaca gtaaaaggag aacgggtatc gttccctgtg tgcacgtaca     2100

tcccggccac catatgcgat cagatgactg gtataatggc cacggatata tcacctgacg     2160

atgcacaaaa acttctggtt gggctcaacc agcgaattgt cattaacggt aggactaaca     2220

ggaacaccaa caccatgcaa aattaccttc tgccgatcat agcacaaggg ttcagcaaat     2280

gggctaagga gcgcaaggat gatcttgata acgagaaaat gctgggtact agagaacgca     2340

agcttacgta tggctgcttg tgggcgtttc gcactaagaa agtacattcg ttttatcgcc     2400

cacctggaac gcagacctgc gtaaaagtcc cagcctcttt tagcgctttt cccatgtcgt     2460

ccgtatggac gacctctttg cccatgtcgc tgaggcagaa attgaaactg gcattgcaac     2520

caaagaagga ggaaaaactg ctgcaggtct cggaggaatt agtcatggag gccaaggctg     2580

cttttgagga tgctcaggag gaagccagag cggagaagct ccgagaagca cttccaccat     2640

tagtggcaga caaaggcatc gaggcagccg cagaagttgt ctgcgaagtg gaggggctcc     2700

aggcggacat cggagcagca ttagttgaaa ccccgcgcgg tcacgtaagg ataatacctc     2760

aagcaaatga ccgtatgatc ggacagtata tcgttgtctc gccaaactct gtgctgaaga     2820

atgccaaact cgcaccagcg cacccgctag cagatcaggt taagatcata acacactccg     2880

gaagatcagg aaggtacgcg gtcgaaccat acgacgctaa agtactgatg ccagcaggag     2940

gtgccgtacc atggccagaa ttcctagcac tgagtgagag cgccacgtta gtgtacaacg     3000

aaagagagtt tgtgaaccgc aaactatacc acattgccat gcatggcccc gccaagaata     3060

cagaagagga gcagtacaag gttacaaagg cagagcttgc agaaacagag tacgtgtttg     3120

acgtggacaa gaagcgttgc gttaagaagg aagaagcctc aggtctggtc ctctcgggag     3180

aactgaccaa ccctccctat catgagctag ctctggaggg actgaagacc cgacctgcgg     3240

tcccgtacaa ggtcgaaaca ataggagtga taggcacacc ggggtcgggc aagtcagcta     3300

ttatcaagtc aactgtcacg gcacgagatc ttgttaccag cggaaagaaa gaaaattgtc     3360

gcgaaattga ggccgacgtg ctaagactga ggggtatgca gattacgtcg aagacagtag     3420

attcggttat gctcaacgga tgccacaaag ccgtagaagt gctgtacgtt gacgaagcgt     3480

tcgcgtgcca cgcaggagca ctacttgcct tgattgctat cgtcaggccc cgcaagaagg     3540

tagtactatg cggagacccc atgcaatgcg gattcttcaa catgatgcaa ctaaaggtac     3600

atttcaatca ccctgaaaaa gacatatgca ccaagacatt ctacaagtat atctcccggc     3660

gttgcacaca gccagttaca gctattgtat cgacactgca ttacgatgga aagatgaaaa     3720

ccacgaaccc gtgcaagaag aacattgaaa tcgatattac aggggccaca aagccgaagc     3780

caggggatat catcctgaca tgtttccgcg ggtgggttaa gcaattgcaa atcgactatc     3840

ccggacatga agtaatgaca gccgcggcct cacaagggct aaccagaaaa ggagtgtatg     3900

ccgtccggca aaaagtcaat gaaaacccac tgtacgcgat cacatcagag catgtgaacg     3960

tgttgctcac ccgcactgag gacaggctag tgtggaaaac cttgcagggc gacccatgga     4020

ttaagcagct cactaacata cctaaaggaa actttcaggc tactatagag gactgggaag     4080

ctgaacacaa gggaataatt gctgcaataa acagccccac tccccgtgcc aatccgttca     4140

gctgcaagac caacgtttgc tgggcgaaag cattggaacc gatactagcc acggccggta     4200

tcgtacttac cggttgccag tggagcgaac tgttcccaca gtttgcggat gacaaaccac     4260

attcggccat ttacgcctta gacgtaattt gcattaagtt tttcggcatg gacttgacaa     4320

gcggactgtt ttctaaacag agcatcccac taacgtacca tcccgccgat tcagcgaggc     4380

cggtagctca ttgggacaac agcccaggaa cccgcaagta tgggtacgat cacgccattg     4440

ccgccgaact ctcccgtaga tttccggtgt tccagctagc tgggaagggc acacaacttg     4500

atttgcagac ggggagaacc agagttatct ctgcacagca taacctggtc ccggtgaacc     4560

gcaatcttcc tcacgcctta gtccccgagt acaaggagaa gcaacccggc ccggtcgaaa     4620

aattcttgaa ccagttcaaa caccactcag tacttgtggt atcagaggaa aaaattgaag     4680

ctccccgtaa gagaatcgaa tggatcgccc cgattggcat agccggtgca gataagaact     4740

acaacctggc tttcgggttt ccgccgcagg cacggtacga cctggtgttc atcaacattg     4800

gaactaaata cagaaaccac cactttcagc agtgcgaaga ccatgcggcg accttaaaaa     4860

ccctttcgcg ttcggccctg aattgcctta acccaggagg caccctcgtg gtgaagtcct     4920

atggctacgc cgaccgcaac agtgaggacg tagtcaccgc tcttgccaga aagtttgtca     4980

gggtgtctgc agcgagacca gattgtgtct caagcaatac agaaatgtac ctgattttcc     5040

gacaactaga caacagccgt acacggcaat tcaccccgca ccatctgaat tgcgtgattt     5100

cgtccgtgta tgagggtaca agagatggag ttggagccgc gccgtcatac cgcaccaaaa     5160

gggagaatat tgctgactgt caagaggaag cagttgtcaa cgcagccaat ccgctgggta     5220

gaccaggcga aggagtctgc cgtgccatct ataaacgttg gccgaccagt tttaccgatt     5280

cagccacgga gacaggcacc gcaagaatga ctgtgtgcct aggaaagaaa gt             5332


<210>  7
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nsp1 polypeptide

<400>  7

Met Glu Lys Pro Val Val Asn Val Asp Val Asp Pro Gln Ser Pro Phe 
1               5                   10                  15      


Val Val Gln Leu Gln Lys Ser Phe Pro Gln Phe Glu Val Val Ala Gln 
            20                  25                  30          


Gln Val Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu 
        35                  40                  45              


Ala Ser Lys Leu Ile Glu Leu Glu Val Pro Thr Thr Ala Thr Ile Leu 
    50                  55                  60                  


Asp Ile Gly Ser Ala Pro Ala Arg Arg Met Phe Ser Glu His Gln Tyr 
65                  70                  75                  80  


His Cys Val Cys Pro Met Arg Ser Pro Glu Asp Pro Asp Arg Met Met 
                85                  90                  95      


Lys Tyr Ala Ser Lys Leu Ala Glu Lys Ala Cys Lys Ile Thr Asn Lys 
            100                 105                 110         


Asn Leu His Glu Lys Ile Lys Asp Leu Arg Thr Val Leu Asp Thr Pro 
        115                 120                 125             


Asp Ala Glu Thr Pro Ser Leu Cys Phe His Asn Asp Val Thr Cys Asn 
    130                 135                 140                 


Met Arg Ala Glu Tyr Ser Val Met Gln Asp Val Tyr Ile Asn Ala Pro 
145                 150                 155                 160 


Gly Thr Ile Tyr His Gln Ala Met Lys Gly Val Arg Thr Leu Tyr Trp 
                165                 170                 175     


Ile Gly Phe Asp Thr Thr Gln Phe Met Phe Ser Ala Met Ala Gly Ser 
            180                 185                 190         


Tyr Pro Ala Tyr Asn Thr Asn Trp Ala Asp Glu Lys Val Leu Glu Ala 
        195                 200                 205             


Arg Asn Ile Gly Leu Cys Ser Thr Lys Leu Ser Glu Gly Arg Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Met Arg Lys Lys Glu Leu Lys Pro Gly Ser Arg Val 
225                 230                 235                 240 


Tyr Phe Ser Val Gly Ser Thr Leu Tyr Pro Glu His Arg Ala Ser Leu 
                245                 250                 255     


Gln Ser Trp His Leu Pro Ser Val Phe His Leu Asn Gly Lys Gln Ser 
            260                 265                 270         


Tyr Thr Cys Arg Cys Asp Thr Val Val Ser Cys Glu Gly Tyr Val Val 
        275                 280                 285             


Lys Lys Ile Thr Ile Ser Pro Gly Ile Thr Gly Glu Thr Val Gly Tyr 
    290                 295                 300                 


Ala Val Thr His Asn Ser Glu Gly Phe Leu Leu Cys Lys Val Thr Asp 
305                 310                 315                 320 


Thr Val Lys Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Ile Pro 
                325                 330                 335     


Ala Thr Ile Cys Asp Gln Met Thr Gly Ile Met Ala Thr Asp Ile Ser 
            340                 345                 350         


Pro Asp Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val 
        355                 360                 365             


Ile Asn Gly Arg Thr Asn Arg Asn Thr Asn Thr Met Gln Asn Tyr Leu 
    370                 375                 380                 


Leu Pro Ile Ile Ala Gln Gly Phe Ser Lys Trp Ala Lys Glu Arg Lys 
385                 390                 395                 400 


Asp Asp Leu Asp Asn Glu Lys Met Leu Gly Thr Arg Glu Arg Lys Leu 
                405                 410                 415     


Thr Tyr Gly Cys Leu Trp Ala Phe Arg Thr Lys Lys Val His Ser Phe 
            420                 425                 430         


Tyr Arg Pro Pro Gly Thr Gln Thr Cys Val Lys Val Pro Ala Ser Phe 
        435                 440                 445             


Ser Ala Phe Pro Met Ser Ser Val Trp Thr Thr Ser Leu Pro Met Ser 
    450                 455                 460                 


Leu Arg Gln Lys Leu Lys Leu Ala Leu Gln Pro Lys Lys Glu Glu Lys 
465                 470                 475                 480 


Leu Leu Gln Val Ser Glu Glu Leu Val Met Glu Ala Lys Ala Ala Phe 
                485                 490                 495     


Glu Asp Ala Gln Glu Glu Ala Arg Ala Glu Lys Leu Arg Glu Ala Leu 
            500                 505                 510         


Pro Pro Leu Val Ala Asp Lys Gly Ile Glu Ala Ala Ala Glu Val Val 
        515                 520                 525             


Cys Glu Val Glu Gly Leu Gln Ala Asp Ile Gly Ala 
    530                 535                 540 


<210>  8
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nsp2 polypeptide

<400>  8

Ala Leu Val Glu Thr Pro Arg Gly His Val Arg Ile Ile Pro Gln Ala 
1               5                   10                  15      


Asn Asp Arg Met Ile Gly Gln Tyr Ile Val Val Ser Pro Asn Ser Val 
            20                  25                  30          


Leu Lys Asn Ala Lys Leu Ala Pro Ala His Pro Leu Ala Asp Gln Val 
        35                  40                  45              


Lys Ile Ile Thr His Ser Gly Arg Ser Gly Arg Tyr Ala Val Glu Pro 
    50                  55                  60                  


Tyr Asp Ala Lys Val Leu Met Pro Ala Gly Gly Ala Val Pro Trp Pro 
65                  70                  75                  80  


Glu Phe Leu Ala Leu Ser Glu Ser Ala Thr Leu Val Tyr Asn Glu Arg 
                85                  90                  95      


Glu Phe Val Asn Arg Lys Leu Tyr His Ile Ala Met His Gly Pro Ala 
            100                 105                 110         


Lys Asn Thr Glu Glu Glu Gln Tyr Lys Val Thr Lys Ala Glu Leu Ala 
        115                 120                 125             


Glu Thr Glu Tyr Val Phe Asp Val Asp Lys Lys Arg Cys Val Lys Lys 
    130                 135                 140                 


Glu Glu Ala Ser Gly Leu Val Leu Ser Gly Glu Leu Thr Asn Pro Pro 
145                 150                 155                 160 


Tyr His Glu Leu Ala Leu Glu Gly Leu Lys Thr Arg Pro Ala Val Pro 
                165                 170                 175     


Tyr Lys Val Glu Thr Ile Gly Val Ile Gly Thr Pro Gly Ser Gly Lys 
            180                 185                 190         


Ser Ala Ile Ile Lys Ser Thr Val Thr Ala Arg Asp Leu Val Thr Ser 
        195                 200                 205             


Gly Lys Lys Glu Asn Cys Arg Glu Ile Glu Ala Asp Val Leu Arg Leu 
    210                 215                 220                 


Arg Gly Met Gln Ile Thr Ser Lys Thr Val Asp Ser Val Met Leu Asn 
225                 230                 235                 240 


Gly Cys His Lys Ala Val Glu Val Leu Tyr Val Asp Glu Ala Phe Ala 
                245                 250                 255     


Cys His Ala Gly Ala Leu Leu Ala Leu Ile Ala Ile Val Arg Pro Arg 
            260                 265                 270         


Lys Lys Val Val Leu Cys Gly Asp Pro Met Gln Cys Gly Phe Phe Asn 
        275                 280                 285             


Met Met Gln Leu Lys Val His Phe Asn His Pro Glu Lys Asp Ile Cys 
    290                 295                 300                 


Thr Lys Thr Phe Tyr Lys Tyr Ile Ser Arg Arg Cys Thr Gln Pro Val 
305                 310                 315                 320 


Thr Ala Ile Val Ser Thr Leu His Tyr Asp Gly Lys Met Lys Thr Thr 
                325                 330                 335     


Asn Pro Cys Lys Lys Asn Ile Glu Ile Asp Ile Thr Gly Ala Thr Lys 
            340                 345                 350         


Pro Lys Pro Gly Asp Ile Ile Leu Thr Cys Phe Arg Gly Trp Val Lys 
        355                 360                 365             


Gln Leu Gln Ile Asp Tyr Pro Gly His Glu Val Met Thr Ala Ala Ala 
    370                 375                 380                 


Ser Gln Gly Leu Thr Arg Lys Gly Val Tyr Ala Val Arg Gln Lys Val 
385                 390                 395                 400 


Asn Glu Asn Pro Leu Tyr Ala Ile Thr Ser Glu His Val Asn Val Leu 
                405                 410                 415     


Leu Thr Arg Thr Glu Asp Arg Leu Val Trp Lys Thr Leu Gln Gly Asp 
            420                 425                 430         


Pro Trp Ile Lys Gln Leu Thr Asn Ile Pro Lys Gly Asn Phe Gln Ala 
        435                 440                 445             


Thr Ile Glu Asp Trp Glu Ala Glu His Lys Gly Ile Ile Ala Ala Ile 
    450                 455                 460                 


Asn Ser Pro Thr Pro Arg Ala Asn Pro Phe Ser Cys Lys Thr Asn Val 
465                 470                 475                 480 


Cys Trp Ala Lys Ala Leu Glu Pro Ile Leu Ala Thr Ala Gly Ile Val 
                485                 490                 495     


Leu Thr Gly Cys Gln Trp Ser Glu Leu Phe Pro Gln Phe Ala Asp Asp 
            500                 505                 510         


Lys Pro His Ser Ala Ile Tyr Ala Leu Asp Val Ile Cys Ile Lys Phe 
        515                 520                 525             


Phe Gly Met Asp Leu Thr Ser Gly Leu Phe Ser Lys Gln Ser Ile Pro 
    530                 535                 540                 


Leu Thr Tyr His Pro Ala Asp Ser Ala Arg Pro Val Ala His Trp Asp 
545                 550                 555                 560 


Asn Ser Pro Gly Thr Arg Lys Tyr Gly Tyr Asp His Ala Ile Ala Ala 
                565                 570                 575     


Glu Leu Ser Arg Arg Phe Pro Val Phe Gln Leu Ala Gly Lys Gly Thr 
            580                 585                 590         


Gln Leu Asp Leu Gln Thr Gly Arg Thr Arg Val Ile Ser Ala Gln His 
        595                 600                 605             


Asn Leu Val Pro Val Asn Arg Asn Leu Pro His Ala Leu Val Pro Glu 
    610                 615                 620                 


Tyr Lys Glu Lys Gln Pro Gly Pro Val Glu Lys Phe Leu Asn Gln Phe 
625                 630                 635                 640 


Lys His His Ser Val Leu Val Val Ser Glu Glu Lys Ile Glu Ala Pro 
                645                 650                 655     


Arg Lys Arg Ile Glu Trp Ile Ala Pro Ile Gly Ile Ala Gly Ala Asp 
            660                 665                 670         


Lys Asn Tyr Asn Leu Ala Phe Gly Phe Pro Pro Gln Ala Arg Tyr Asp 
        675                 680                 685             


Leu Val Phe Ile Asn Ile Gly Thr Lys Tyr Arg Asn His His Phe Gln 
    690                 695                 700                 


Gln Cys Glu Asp His Ala Ala Thr Leu Lys Thr Leu Ser Arg Ser Ala 
705                 710                 715                 720 


Leu Asn Cys Leu Asn Pro Gly Gly Thr Leu Val Val Lys Ser Tyr Gly 
                725                 730                 735     


Tyr Ala Asp Arg Asn Ser Glu Asp Val Val Thr Ala Leu Ala Arg Lys 
            740                 745                 750         


Phe Val Arg Val Ser Ala Ala Arg Pro Asp Cys Val Ser Ser Asn Thr 
        755                 760                 765             


Glu Met Tyr Leu Ile Phe Arg Gln Leu Asp Asn Ser Arg Thr Arg Gln 
    770                 775                 780                 


Phe Thr Pro His His Leu Asn Cys Val Ile Ser Ser Val Tyr Glu Gly 
785                 790                 795                 800 


Thr Arg Asp Gly Val Gly Ala 
                805         


<210>  9
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nsp3 polypeptide

<400>  9

Ala Pro Ser Tyr Arg Thr Lys Arg Glu Asn Ile Ala Asp Cys Gln Glu 
1               5                   10                  15      


Glu Ala Val Val Asn Ala Ala Asn Pro Leu Gly Arg Pro Gly Glu Gly 
            20                  25                  30          


Val Cys Arg Ala Ile Tyr Lys Arg Trp Pro Thr Ser Phe Thr Asp Ser 
        35                  40                  45              


Ala Thr Glu Thr Gly Thr Ala Arg Met Thr Val Cys Leu Gly Lys Lys 
    50                  55                  60                  


Val Ile His Ala Val Gly Pro Asp Phe Arg Lys His Pro Glu Ala Glu 
65                  70                  75                  80  


Ala Leu Lys Leu Leu Gln Asn Ala Tyr His Ala Val Ala Asp Leu Val 
                85                  90                  95      


Asn Glu His Asn Ile Lys Ser Val Ala Ile Pro Leu Leu Ser Thr Gly 
            100                 105                 110         


Ile Tyr Ala Ala Gly Lys Asp Arg Leu Glu Val Ser Leu Asn Cys Leu 
        115                 120                 125             


Thr Thr Ala Leu Asp Arg Thr Asp Ala Asp Val Thr Ile Tyr Cys Leu 
    130                 135                 140                 


Asp Lys Lys Trp Lys Glu Arg Ile Asp Ala Ala Leu Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Val Thr Glu Leu Lys Asp Glu Asp Met Glu Ile Asp Asp Glu Leu 
                165                 170                 175     


Val Trp Ile His Pro Asp Ser Cys Leu Lys Gly Arg Lys Gly Phe Ser 
            180                 185                 190         


Thr Thr Lys Gly Lys Leu Tyr Ser Tyr Phe Glu Gly Thr Lys Phe His 
        195                 200                 205             


Gln Ala Ala Lys Asp Met Ala Glu Ile Lys Val Leu Phe Pro Asn Asp 
    210                 215                 220                 


Gln Glu Ser Asn Glu Gln Leu Cys Ala Tyr Ile Leu Gly Glu Thr Met 
225                 230                 235                 240 


Glu Ala Ile Arg Glu Lys Cys Pro Val Asp His Asn Pro Ser Ser Ser 
                245                 250                 255     


Pro Pro Lys Thr Leu Pro Cys Leu Cys Met Tyr Ala Met Thr Pro Glu 
            260                 265                 270         


Arg Val His Arg Leu Arg Ser Asn Asn Val Lys Glu Val Thr Val Cys 
        275                 280                 285             


Ser Ser Thr Pro Leu Pro Lys His Lys Ile Lys Asn Val Gln Lys Val 
    290                 295                 300                 


Gln Cys Thr Lys Val Val Leu Phe Asn Pro His Thr Pro Ala Phe Val 
305                 310                 315                 320 


Pro Ala Arg Lys Tyr Ile Glu Val Pro Glu Gln Pro Thr Ala Pro Pro 
                325                 330                 335     


Ala Gln Ala Glu Glu Ala Pro Glu Val Val Ala Thr Pro Ser Pro Ser 
            340                 345                 350         


Thr Ala Asp Asn Thr Ser Leu Asp Val Thr Asp Ile Ser Leu Asp Met 
        355                 360                 365             


Asp Asp Ser Ser Glu Gly Ser Leu Phe Ser Ser Phe Ser Gly Ser Asp 
    370                 375                 380                 


Asn Ser Ile Thr Ser Met Asp Ser Trp Ser Ser Gly Pro Ser Ser Leu 
385                 390                 395                 400 


Glu Ile Val Asp Arg Arg Gln Val Val Val Ala Asp Val His Ala Val 
                405                 410                 415     


Gln Glu Pro Ala Pro Ile Pro Pro Pro Arg Leu Lys Lys Met Ala Arg 
            420                 425                 430         


Leu Ala Ala Ala Arg Lys Glu Pro Thr Pro Pro Ala Ser Asn Ser Ser 
        435                 440                 445             


Glu Ser Leu His Leu Ser Phe Gly Gly Val Ser Met Ser Leu Gly Ser 
    450                 455                 460                 


Ile Phe Asp Gly Glu Thr Ala Arg Gln Ala Ala Val Gln Pro Leu Ala 
465                 470                 475                 480 


Thr Gly Pro Thr Asp Val Pro Met Ser Phe Gly Ser Phe Ser Asp Gly 
                485                 490                 495     


Glu Ile Asp Glu Leu Ser Arg Arg Val Thr Glu Ser Glu Pro Val Leu 
            500                 505                 510         


Phe Gly Ser Phe Glu Pro Gly Glu Val Asn Ser Ile Ile Ser Ser Arg 
        515                 520                 525             


Ser Ala Val Ser Phe Pro Leu Arg Lys Gln Arg Arg Arg Arg Arg Ser 
    530                 535                 540                 


Arg Arg Thr Glu Tyr 
545                 


<210>  10
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nsp4 polypeptide

<400>  10

Leu Thr Gly Val Gly Gly Tyr Ile Phe Ser Thr Asp Thr Gly Pro Gly 
1               5                   10                  15      


His Leu Gln Lys Lys Ser Val Leu Gln Asn Gln Leu Thr Glu Pro Thr 
            20                  25                  30          


Leu Glu Arg Asn Val Leu Glu Arg Ile His Ala Pro Val Leu Asp Thr 
        35                  40                  45              


Ser Lys Glu Glu Gln Leu Lys Leu Arg Tyr Gln Met Met Pro Thr Glu 
    50                  55                  60                  


Ala Asn Lys Ser Arg Tyr Gln Ser Arg Lys Val Glu Asn Gln Lys Ala 
65                  70                  75                  80  


Ile Thr Thr Glu Arg Leu Leu Ser Gly Leu Arg Leu Tyr Asn Ser Ala 
                85                  90                  95      


Thr Asp Gln Pro Glu Cys Tyr Lys Ile Thr Tyr Pro Lys Pro Leu Tyr 
            100                 105                 110         


Ser Ser Ser Val Pro Ala Asn Tyr Ser Asp Pro Gln Phe Ala Val Ala 
        115                 120                 125             


Val Cys Asn Asn Tyr Leu His Glu Asn Tyr Pro Thr Val Ala Ser Tyr 
    130                 135                 140                 


Gln Ile Thr Asp Glu Tyr Asp Ala Tyr Leu Asp Met Val Asp Gly Thr 
145                 150                 155                 160 


Val Ala Cys Leu Asp Thr Ala Thr Phe Cys Pro Ala Lys Leu Arg Ser 
                165                 170                 175     


Tyr Pro Lys Lys His Glu Tyr Arg Ala Pro Asn Ile Arg Ser Ala Val 
            180                 185                 190         


Pro Ser Ala Met Gln Asn Thr Leu Gln Asn Val Leu Ile Ala Ala Thr 
        195                 200                 205             


Lys Arg Asn Cys Asn Val Thr Gln Met Arg Glu Leu Pro Thr Leu Asp 
    210                 215                 220                 


Ser Ala Thr Phe Asn Val Glu Cys Phe Arg Lys Tyr Ala Cys Asn Asp 
225                 230                 235                 240 


Glu Tyr Trp Glu Glu Phe Ala Arg Lys Pro Ile Arg Ile Thr Thr Glu 
                245                 250                 255     


Phe Val Thr Ala Tyr Val Ala Arg Leu Lys Gly Pro Lys Ala Ala Ala 
            260                 265                 270         


Leu Phe Ala Lys Thr Tyr Asn Leu Val Pro Leu Gln Glu Val Pro Met 
        275                 280                 285             


Asp Arg Phe Val Met Asp Met Lys Arg Asp Val Lys Val Thr Pro Gly 
    290                 295                 300                 


Thr Lys His Thr Glu Glu Arg Pro Lys Val Gln Val Ile Gln Ala Ala 
305                 310                 315                 320 


Glu Pro Leu Ala Thr Ala Tyr Leu Cys Gly Ile His Arg Glu Leu Val 
                325                 330                 335     


Arg Arg Leu Thr Ala Val Leu Leu Pro Asn Ile His Thr Leu Phe Asp 
            340                 345                 350         


Met Ser Ala Glu Asp Phe Asp Ala Ile Ile Ala Glu His Phe Lys Gln 
        355                 360                 365             


Gly Asp Pro Val Leu Glu Thr Asp Ile Ala Ser Phe Asp Lys Ser Gln 
    370                 375                 380                 


Asp Asp Ala Met Ala Leu Thr Gly Leu Met Ile Leu Glu Asp Leu Gly 
385                 390                 395                 400 


Val Asp Gln Pro Leu Leu Asp Leu Ile Glu Cys Ala Phe Gly Glu Ile 
                405                 410                 415     


Ser Ser Thr His Leu Pro Thr Gly Thr Arg Phe Lys Phe Gly Ala Met 
            420                 425                 430         


Met Lys Ser Gly Met Phe Leu Thr Leu Phe Val Asn Thr Val Leu Asn 
        435                 440                 445             


Val Val Ile Ala Ser Arg Val Leu Glu Glu Arg Leu Lys Thr Ser Arg 
    450                 455                 460                 


Cys Ala Ala Phe Ile Gly Asp Asp Asn Ile Ile His Gly Val Val Ser 
465                 470                 475                 480 


Asp Lys Glu Met Ala Glu Arg Cys Ala Thr Trp Leu Asn Met Glu Val 
                485                 490                 495     


Lys Ile Ile Asp Ala Val Ile Gly Glu Arg Pro Pro Tyr Phe Cys Gly 
            500                 505                 510         


Gly Phe Ile Leu Gln Asp Ser Val Thr Ser Thr Ala Cys Arg Val Ala 
        515                 520                 525             


Asp Pro Leu Lys Arg Leu Phe Lys Leu Gly Lys Pro Leu Pro Ala Asp 
    530                 535                 540                 


Asp Glu Gln Asp Glu Asp Arg Arg Arg Ala Leu Leu Asp Glu Thr Lys 
545                 550                 555                 560 


Ala Trp Phe Arg Val Gly Ile Thr Gly Thr Leu Ala Val Ala Val Thr 
                565                 570                 575     


Thr Arg Tyr Glu Val Asp Asn Ile Thr Pro Val Leu Leu Ala Leu Arg 
            580                 585                 590         


Thr Phe Ala Gln Ser Lys Arg Ala Phe Gln Ala Ile Arg Gly Glu Ile 
        595                 600                 605             


Lys His Leu Tyr Gly Gly Pro Lys 
    610                 615     


<210>  11
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  subgenomic promoter (PSG) sequence, Sindbis 3'CSE

<400>  11
cttgcagcat gatgctgact agcacacgaa gatgaccgct acgccccaat gatccgacca       60

gcaaaactcg atgtacttcc gaggaactga tgtgcataat gcatcaggct ggtacattag      120

atccccgctt accgcgggca atatagcaac actaaaaact cgatgtactt ccgaggaagc      180

gcagtgcata atgctgcgca gtgttgccac ataaccacta tattaaccat ttatctagcg      240

gacgccaaaa actcaatgta tttctgagga agcgtggtgc ataatgccac gcagcgtctg      300

cataactttt attatttctt ttattaatca acaaaatttt gtttttaaca tttc            354


<210>  12
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse-orientation promoter 5'UTR+5'CSE (rPSG)

<400>  12
attgacggcg tagtacacac tattgaatca aacagccgac caattgcact accatcacaa       60

tggagaagcc agtagtaaac gtagacgtag acccccagag tccgtttgtc gtgcaactgc      120

aaaaaagctt cccgcaattt gaggtagtag cacagcaggt cactccaaat gaccatgcta      180

atgccagagc attttcgcat ctggccagta aactaatcga gctggaggtt cctaccacag      240

cgacgatctt ggacataggc agcgcaccgg ctcgtagaat gttttccgag caccagtatc      300

attgtgtctg ccccatgcgt agtccagaag acccggaccg catgatgaaa tacgccagta      360

aactggcgga aaaagcgtgc aagattacaa acaagaactt gcatgagaag attaaggatc      420

tccgg                                                                  425


<210>  13
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  internal subgenomic promoter for RdRp (iPSG)

<400>  13
aagattcggt tacttccaca gcgtgccgcg tggcggatcc cctgaaaagg ctgtttaagt       60

tgggtaaacc gctcccagcc gacgacgagc aagacgaaga cagaagacgc gctctgctag      120

atgaaacaaa ggcgtggttt agagtaggta taacaggcac tttagcagtg gccgtgacga      180

cccggtatga ggtagacaat attacacctg tcctactggc attgagaact tttgcccaga      240

gcaaaagagc attccaagcc atcagagggg aaataaagca tctctacggt ggtcctaaat      300

agtcagcata gtacatttca tctgactaat actacaacac caccacc                    347


<210>  14
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  piggyBac (PB) transposon sequence, PiggyBAC 5' Terminal Repeat

<400>  14
cattctagat taaccctaga aagatagtct gcgtaaaatt gacgcatgca ttcttgaaat       60

attgctctct ctttctaaat agcgcgaatc cgtcgctgtg catttaggac atctcagtcg      120

ccgcttggag ctcccgtgag gcgtgcttgt caatgcggta agtgtcactg attttgaact      180

ataacgaccg cgtgagtcaa aatgacgcat gattatcttt tacgtgactt ttaagattta      240

actcatacga taattatatt gttatttcat gttctactta cgtgataact tattatatat      300

atattttctt gttatagata tcaactagaa tgctagcatg ggcccat                    347


<210>  15
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB transposon sequence, PiggyBAC 3' Terminal Repeat

<400>  15
agttttgtta ctttatagaa gaaattttga gtttttgttt ttttttaata aataaataaa       60

cataaataaa ttgtttgttg aatttattat tagtatgtaa gtgtaaatat aataaaactt      120

aatatctatt caaattaata aataaacctc gatatacaga ccgataaaac acatgcgtca      180

attttacgca tgattatctt taacgtacgt cacaatatga ttatctttct agggttaatc      240

tag                                                                    243


<210>  16
<211>  8951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transposable Sindbis amplifiable lentiviral transfer cassette 
       sequence

<400>  16
gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag ctggcgaaag       60

ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag tcacgacgtt      120

gtaaaacgac ggccagtgag cgcgcgtaat acgactcact atagggcgaa ttggggcgcg      180

ccattctaga ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa      240

tattgctctc tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc      300

gccgcttgga gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac      360

tataacgacc gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt      420

aactcatacg ataattatat tgttatttca tgttctactt acgtgataac ttattatata      480

tatattttct tgttatagat atcaactaga atgctagcgc ggccgcctcg agggatccgg      540

agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag caacatgcct      600

tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg tacgatcgtg      660

ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact gaattccgca      720

ttgcagagat attgtattta agtgcctagc tcgataccgt cgagattgac ggcgtagtac      780

acactattga atcaaacagc cgaccaattg cactaccatc acaatggaga agccagtagt      840

aaacgtagac gtagaccccc agagtccgtt tgtcgtgcaa ctgcaaaaaa gcttcccgca      900

atttgaggta gtagcacagc aggtcactcc aaatgaccat gctaatgcca gagcattttc      960

gcatctggcc agtaaactaa tcgagctgga ggttcctacc acagcgacga tcttggacat     1020

aggcagcgca ccggctcgta gaatgttttc cgagcaccag tatcattgtg tctgccccat     1080

gcgtagtcca gaagacccgg accgcatgat gaaatatgcc agtaaactgg cggaaaaagc     1140

gtgcaagatt acaaacaaga acttgcatga gaagattaag gatctccgga ccgtacttga     1200

tacgccggat gctgaaacac catcgctctg ctttcacaac gatgttacct gcaacatgcg     1260

tgccgaatat tccgtcatgc aggacgtgta tagagccgag ggccgagggt ccctcctgac     1320

atgcggagac gttgaggaaa atcctggacc aatgggaacc tcacttcttt gctggatggc     1380

actttgtctt cttggagccg atcacgcaga tgctgagcag aagctcatca gtgaagagga     1440

cttgtctgga gggggaggga gtccggctcc caggccgcca acacctgcgc caactatcgc     1500

ctcccagcca ttgtccttga ggccagaggc atgtcgcccc gcagcgggag gcgccgtcca     1560

tacccgcggt ttggacttcg catgtgatat ttatatttgg gctccactcg cgggtacatg     1620

cggagtcttg ttgctctctc ttgtgattac gctttactgc aaccaccgga acagaaggcg     1680

agtatgtaaa tgtccccggc ccgtagtata gtcagcatag tacatttcat ctgactaata     1740

ctacaacacc accacctcta gaaccggtaa ggcaagcttt attgaggctt aagcagtggg     1800

ttccctagtt agccagagag ctcccaggct cagatctggt ctaaccagag agacccagta     1860

caagcaaaaa gcagatcttg tcttcgttgg gagtgaatta gcccttccag tccccccttt     1920

tcttttaaaa agtggctaag atctacagct gccttgtaag tcattggtct taaaggtacc     1980

gagctcgaat tccaggcggg gaggcggccc aaagggagat ccgactcgtc tgagggcgaa     2040

ggcgaagacg cggaagaggc cgcagagccg gcagcaggcc gcgggaagga aggtccgctg     2100

gattgagggc cgaagggacg tagcagaagg acgtcccgcg cagaatccag gtggcaacac     2160

aggcgagcag ccaaggaaag gacgatgatt tccccgacaa caccacggaa ttgtcagtgc     2220

ccaacagccg agcccctgtc cagcagcggg caaggcaggc ggcgatgagt tccgccgtgg     2280

caatagggag ggggaaagcg aaagtcccgg aaaggagctg acaggtggtg gcaatgcccc     2340

aaccagtggg ggttgcgtca gcaaacacag tgcacaccac gccacgttgc ctgacaacgg     2400

gccacaactc ctcataaaga gacagcaacc aggatttata caaggaggag aaaatgaaag     2460

ccatacggga agcaatagca tgatacaaag gcattaaagc agcgtatcca catagcgtaa     2520

aaggagcaac atagttaaga ataccagtca atctttcaca aattttgtaa tccagaggtt     2580

gattgtcgag cccgggatct ctcgagacgc gttcaccggg gtggcagggc ctgcatgtgc     2640

agggcgtcgt aggtgtcctt ggtggcggtg ctcaggccct ggtacaggcc gtcgtggccc     2700

ttgccccggc gccgctcgcc cttcatgccg atctcgctgt aggcctcggc catcttgtcc     2760

ttctgcagct cgttgtacag gccctcctgg ggattcttcc ggcgaggctt gccgcccatc     2820

tcggggtccc gtccccgccg cttgtccagc acgtcgtact cctcccgccg tcccaggttc     2880

agctcgttgt acagctggtt ctggccctgc tggtaggctg gggcgtcggc gctccggctg     2940

aacttcaccc gcagctcgca gccgccttcc tcttcctcgg ggaaccggca gctgcagccg     3000

tcctcctcct gggtggtctg cacgggccgc atgaagggct gcttgaagat gtacagcagc     3060

ttcttccggc cccgtttgca atacagtgta atcaccaggg acagcagcag caccccgcat     3120

gtcccggcca ggggggccca gatatagatg tcgcaggcga agtccaggcc ccttgtgtgc     3180

acggctcctc cggcggcagg cctgcaggct tcaggccgca ggctcagggg ctggctggcg     3240

atggttgggg caggggtagg tggccgtggg gctggggtgg tggtgggatc cgaccgcttc     3300

agctccagct tggtgccggc gccgaaggtc agaggattga tgttccactg ctggcagtag     3360

taggtggcgg cgtcctcggc ctccatgttg ttgatggtca ggaagtagct ggtgccgctg     3420

ccgctgccgc tgaagcggtc gggcacgccg ctggccagct tgctggtgtc gtagatccac     3480

cgcttagggc tggtgccgct cttctgctgg taccagtgca tgtagctcac gctgctgctg     3540

gcgctgcagg tcatggtcac cttctcgcca gggctggcgc tcatgatggc agggctctgg     3600

gtcagcacga tctggctgcc gcctccgcca gagccacctc cgccagagcc gccaccgcca     3660

gagctcacgg tcagggtggt gccctggccc cagtagtcca ggtagtcgcc gtacagcagg     3720

ctccgggcgc agaagtacac ggcgctgtcc tcgctggtca ggctgctcag ctgcatgtag     3780

gcggtggtgc tgctcttgtc ggcggtcagg gtggccttgt ccttgaactt gccgctgtag     3840

ttggtgtcct cgtcgccggg gtagatccgg ccgatccact ccaggccctt gccaggccgc     3900

tgcttcaccc agttcatcca gctgctgctg aaggcgtagc cgctggcctt gcagctgatc     3960

ttcacgctgg ctccgggctt caccagctcg ggtccgctct gctgcagctg cacctgggcg     4020

tcggcgtggt cggctcccag caggcacagg gccatccagc acagcaggct ggtgcccatg     4080

gtggcgtcga ccctggggag agaggtcggt gattcggtca acgagggagc cgactgccga     4140

cgtgcgctcc ggaggcttgc agaatgcgga acaccgcgcg ggcaggaaca gggcccacac     4200

taccgcccca caccccgcct cccgcaccgc cccttcccgg ccgctgctct cggcgcgccc     4260

tgctgagcag ccgctattgg ccacagccca tcgcggtcgg cgcgctgcca ttgctccctg     4320

gcgctgtccg tctgcgaggg tactagtgag acgtgcggct tccgtttgtc acgtccggca     4380

cgccgcgaac cgcaaggaac cttcccgact taggggcgga gcaggaagcg tcgccggggg     4440

gcccacaagg gtagcggcga agatccgggt gacgctgcga acggacgtga agaatgtgcg     4500

agacccaggg tcggcgccgc tgcgtttccc ggaaccacgc ccagagcagc cgcgtccctg     4560

cgcaaaccca gggctgcctt ggaaaaggcg caaccccaac cccgtggcct gcaggggaat     4620

tcgataaaat tttgaatttt gtaatttgtt tttgtaattc tttagtttgt atgtctgttg     4680

ctattatgtc tactattctt tcccctgcac tgtacccccc aatcccccct tttcttttaa     4740

aagttaaccg ataccgtcga gatccgttca ctaatcgaat ggatctgtct ctgtctctct     4800

ctccaccttc ttcttctatt ccttcgggcc tgtcgggtcc cctcggggtt gggaggtggg     4860

tctgaaacga taatggtgaa tatccctgcc taactctatt cactatagaa agtacagcaa     4920

aaactattct taaacctacc aagcctccta ctatcattat gaataatttt atataccaca     4980

gccaatttgt tatgttaaac caattccaca aacttgccca tttatctaat tccaataatt     5040

cttgttcatt cttttcttgc tggttttgcg attcttcaat taaggagtgt attaagcttg     5100

tgtaattgtt aatttctctg tcccactcca tccaggtcgt gtgattccaa atctgttcca     5160

gagatttatt actccaacta gcattccaag gcacagcagt ggtgcaaatg agttttccag     5220

agcaacccca aatccccagg agctgttgat cctttaggta tctttccaca gccaggattc     5280

ttgcctggag ctgcttgatg ccccagactg tgagttgcaa cagatgctgt tgcgcctcaa     5340

tagccctcag caaattgttc tgctgctgca ctataccaga caataattgt ctggcctgta     5400

ccgtcagcgt cattgacgct gcgcccatag tgcttcctgc tgctcccaag aacccaagga     5460

acaaagctcc tattcccact gctctttttt ctctctgcac cactcttctc tttgccttgg     5520

tgggtgctac tcctaatggt tcaattttta ctactttata tttatataat tcacttctcc     5580

aattgtccct catatctcct cctccaggtc tgaagatcag cggccgcttg ctgtgcggtg     5640

gtcttacttt tgttttgctc ttcctctatc ttgtctaaag cttccttggt gtcttttatc     5700

tctatccttt gatgcacaca atagagggtt gctactgtat tatataatga tctaagttct     5760

tctgatcctg tctgaaggga tggttgtagc tgtcccagta tttgtctaca gccttctgat     5820

gtttctaaca ggccaggatt aactgcgaat cgttctagct ccctgcttgc ccatactata     5880

tgttttaatt tatatttttt ctttccccct ggccttaacc gaattttttc ccatcgcgat     5940

ctaattctcc cccgcttaat actgacgctc tcgcacccat ctctctcctt ctagcctccg     6000

ctagtcaaaa tttttggcgt actcaccagt cgccgcccct cgcctcttgc cgtgcgcgct     6060

tcagcaagcc gagtcctgcg tcgagagagc tcctctggtt tccctttcgc tttcaagtcc     6120

ctgttcgggc gccactgcta gagattttcc acactgacta aaagggtctg agggatctct     6180

agttaccaga gtcacacaac agacgggcac acactacttg aagcactcaa ggcaagcttt     6240

attgaggctt aagcagtggg ttccctagtt agccagagag ctcccaggct cagatctggt     6300

ctaaccagag agacccaccg gtcgctacgc cccaatgatc cgaccagcaa aactcgatgt     6360

acttccgagg aactgatgtg cataatgcag gaattcgata tcaagctaga tctcacgtga     6420

gcatgcaggc cttgggccca atgatccgac cagcaaaact cgatgtactt ccgaggaact     6480

gatgtgcata atgcatcagg ctggtacatt agatccccgc ttaccgcggg caatatagca     6540

acactaaaaa ctcgatgtac ttccgaggaa gcgcagtgca taatgctgcg cagtgttgcc     6600

acataaccac tatattaacc atttatctag cggacgccaa aaactcaatg tatttctgag     6660

gaagcgtggt gcataatgcc acgcagcgtc tgcataactt ttattatttc ttttattaat     6720

caacaaaatt ttgtttttaa catttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     6780

aaagggaatt cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     6840

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     6900

catcaatgta tcttatcatg tctggatccg tcgagacgcg tcctgcaggc ctgcattaga     6960

tccattcatg aatgaattca tgtcgacata ctagttaaaa gttttgttac tttatagaag     7020

aaattttgag tttttgtttt tttttaataa ataaataaac ataaataaat tgtttgttga     7080

atttattatt agtatgtaag tgtaaatata ataaaactta atatctattc aaattaataa     7140

ataaacctcg atatacagac cgataaaaca catgcgtcaa ttttacgcat gattatcttt     7200

aacgtacgtc acaatatgat tatctttcta gggttaatct agtatacgcg gcgacgacct     7260

gactgtttga caattaatca tcggcatagt atatcggcat agtataatac gactcactat     7320

aggagggcca ccatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg     7380

gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg     7440

ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc     7500

ctgaatgaac tgcaagacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct     7560

tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa     7620

gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg     7680

gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa     7740

gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat     7800

gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg     7860

agcatgcccg acggcgagga tctcgtcgtg acacatggcg atgcctgctt gccgaatatc     7920

atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac     7980

cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg     8040

gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc     8100

tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag     8160

cagtactaaa tgttaattaa ctagccatga ccaaaatccc ttaacgtgag ttttcgttcc     8220

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     8280

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     8340

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     8400

atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     8460

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     8520

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     8580

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     8640

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     8700

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     8760

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     8820

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     8880

tggccttttg ctggcctttt gctcacatgt tcttaattaa cagggcgcgt cccattcgcc     8940

attcaggctg c                                                          8951


