﻿               SEQUENCE LISTING

<110> Max Planck Florida Institute for Neuroscience et al. 

<120> Light-gated signaling modulation

<130> Y2970 PCT

<150> US 62/299,214
<151> 2016-02-24

<150> EP 16169851.9
<151> 2016-05-17


<160> 108

<170> BiSSAP 1.3

<210> 1
<211> 1428
<212> DNA
<213> Artificial Sequence

<220> 
<223> CIBN – TEV-N – AsLOV2– TEVseq

<400> 1
atgaatggag ctataggagg tgaccttttg ctcaattttc ctgacatgtc ggtcctagag      60

cgccaaaggg ctcacctcaa gtacctcaat cccacctttg attctcctct cgccggcttc     120

tttgccgatt cttcaatgat taccggcggc gagatggaca gctatctttc gactgccggt     180

ttgaatcttc cgatgatgta cggtgagacg acggtggaag gtgattcaag actctcaatt     240

tcgccggaaa cgacgcttgg gactggaaat ttcaaggcag cgaagtttga tacagagact     300

aaggattgta atgaggcggc gaagaagatg acgatgaaca gagatgacct agtagaagaa     360

ggagaagaag agaagtcgaa aataacagag caaaacaatg ggagcacaaa aagcatcaag     420

aagatgaaac acaaagccaa gaaagaagag aacaatttct ctaatgattc atctaaagtg     480

acgaaggaat tggagaaaac ggattatatt catgcatgcg gtggcggtgg ctctggaggt     540

ggtgggtccg gaggaggcgg ccgctccggt ggatccatgc ttcaacttcc tcctcttgaa     600

cgtcttactc tcgagatggg cgagagcctg ttcaagggac ctagggacta caaccctatc     660

agtagcacaa tttgtcacct gaccaacgag agtgatggcc acacaacaag cctgtacggc     720

atcgggttcg gaccctttat catcaccaac aagcacctgt tcaggcggaa taatggcact     780

ctgctggtgc agagcctgca cggggtgttc aaagtgaaga acacaaccac tctgcagcag     840

cacctgatcg atgggcggga tatgatcatc attaggatgc ccaaggactt cccccctttt     900

cctcagaaac tgaagttccg agagccccag agagaggaga gaatctgtct ggtgaccaca     960

aactttcagg agctcggtag tggtagtggg gagtttctgg caaccacact ggaacggatc    1020

gagaaaaatt tcgtgattac tgatccgaga ctgcctgaca acccaatcat ttttgcgagc    1080

gattccttcc tgcagctgac agaatattct cgggaagaga tcctggggcg caattgccgt    1140

tttctgcagg gacccgagac agaccgtgcc actgttcgga aaatcagaga tgctattgac    1200

aaccagactg aagtgaccgt tcagctgatc aattatacca agagcggcaa gaagttctgg    1260

aacgtgttcc acctgcagcc gatgcgcgat tataagggcg acgtccagta cttcattggc    1320

gtgcagctgg atggcaccga acgtcttcat ggcgccgctg agcgtgaggc ggtctgcctg    1380

atcaaaaaga cagcctttca gattgctgag aacctgtact tccagggc                 1428


<210> 2
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> CIBN – TEV-N – AsLOV2– TEVseq

<400> 2
Met Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met 
1               5                   10                  15      
Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr 
            20                  25                  30          
Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr 
        35                  40                  45              
Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro 
    50                  55                  60                  
Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile 
65                  70                  75                  80  
Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Ala Ala Lys Phe 
                85                  90                  95      
Asp Thr Glu Thr Lys Asp Cys Asn Glu Ala Ala Lys Lys Met Thr Met 
            100                 105                 110         
Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile 
        115                 120                 125             
Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His 
    130                 135                 140                 
Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val 
145                 150                 155                 160 
Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Ala Cys Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Ser Gly Gly Ser 
            180                 185                 190         
Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Glu Met Gly Glu 
        195                 200                 205             
Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
    210                 215                 220                 
Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
225                 230                 235                 240 
Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
                245                 250                 255     
Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
            260                 265                 270         
Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
        275                 280                 285             
Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
    290                 295                 300                 
Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
305                 310                 315                 320 
Asn Phe Gln Glu Leu Gly Ser Gly Ser Gly Glu Phe Leu Ala Thr Thr 
                325                 330                 335     
Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp Pro Arg Leu Pro 
            340                 345                 350         
Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu Gln Leu Thr Glu 
        355                 360                 365             
Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg Phe Leu Gln Gly 
    370                 375                 380                 
Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg Asp Ala Ile Asp 
385                 390                 395                 400 
Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr Thr Lys Ser Gly 
                405                 410                 415     
Lys Lys Phe Trp Asn Val Phe His Leu Gln Pro Met Arg Asp Tyr Lys 
            420                 425                 430         
Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp Gly Thr Glu Arg 
        435                 440                 445             
Leu His Gly Ala Ala Glu Arg Glu Ala Val Cys Leu Ile Lys Lys Thr 
    450                 455                 460                 
Ala Phe Gln Ile Ala Glu Asn Leu Tyr Phe Gln Gly 
465                 470                 475     

<210> 3
<211> 948
<212> DNA
<213> Artificial Sequence

<220> 
<223> V2tail – TEV-N – AsLOV2(BLITz-1)– TEVseq

<400> 3
ggacgcaccc cacccagcct gggtccccaa gatgagtcct gcaccaccgc cagctcctcc      60

ctggccaagg acacttcatc gcttcaactt cctcctcttg aacgtcttac tctcggtggc     120

tctggaggtc tcgagatggg cgagagcctg ttcaagggac ctagggacta caaccctatc     180

agtagcacaa tttgtcacct gaccaacgag agtgatggcc acacaacaag cctgtacggc     240

atcgggttcg gaccctttat catcaccaac aagcacctgt tcaggcggaa taatggcact     300

ctgctggtgc agagcctgca cggggtgttc aaagtgaaga acacaaccac tctgcagcag     360

cacctgatcg atgggcggga tatgatcatc attaggatgc ccaaggactt cccccctttt     420

cctcagaaac tgaagttccg agagccccag agagaggaga gaatctgtct ggtgaccaca     480

aactttcagg agctcggtag tggtagtggg gagtttctgg caaccacact ggaacggatc     540

gagaaaaatt tcgtgattac tgatccgaga ctgcctgaca acccaatcat ttttgcgagc     600

gattccttcc tgcagctgac agaatattct cgggaagaga tcctggggcg caattgccgt     660

tttctgcagg gacccgagac agaccgtgcc actgttcgga aaatcagaga tgctattgac     720

aaccagactg aagtgaccgt tcagctgatc aattatacca agagcggcaa gaagttctgg     780

aacgtgttcc acctgcagcc gatgcgcgat tataagggcg acgtccagta cttcattggc     840

gtgcagctgg atggcaccga acgtcttcat ggcgccgctg agcgtgaggc ggtctgcctg     900

atcaaaaaga cagcctttca gattgctgag aacctgtact tccagggc                  948


<210> 4
<211> 316
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2tail – TEV-N – AsLOV2(BLITz-1)– TEVseq

<400> 4
Gly Arg Thr Pro Pro Ser Leu Gly Pro Gln Asp Glu Ser Cys Thr Thr 
1               5                   10                  15      
Ala Ser Ser Ser Leu Ala Lys Asp Thr Ser Ser Leu Gln Leu Pro Pro 
            20                  25                  30          
Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly Leu Glu Met Gly Glu 
        35                  40                  45              
Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
    50                  55                  60                  
Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
65                  70                  75                  80  
Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
                85                  90                  95      
Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
            100                 105                 110         
Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
        115                 120                 125             
Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
    130                 135                 140                 
Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
145                 150                 155                 160 
Asn Phe Gln Glu Leu Gly Ser Gly Ser Gly Glu Phe Leu Ala Thr Thr 
                165                 170                 175     
Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp Pro Arg Leu Pro 
            180                 185                 190         
Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu Gln Leu Thr Glu 
        195                 200                 205             
Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg Phe Leu Gln Gly 
    210                 215                 220                 
Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg Asp Ala Ile Asp 
225                 230                 235                 240 
Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr Thr Lys Ser Gly 
                245                 250                 255     
Lys Lys Phe Trp Asn Val Phe His Leu Gln Pro Met Arg Asp Tyr Lys 
            260                 265                 270         
Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp Gly Thr Glu Arg 
        275                 280                 285             
Leu His Gly Ala Ala Glu Arg Glu Ala Val Cys Leu Ile Lys Lys Thr 
    290                 295                 300                 
Ala Phe Gln Ile Ala Glu Asn Leu Tyr Phe Gln Gly 
305                 310                 315     

<210> 5
<211> 1110
<212> DNA
<213> Artificial Sequence

<220> 
<223> V2tail – CIBN – AsLOV2(BLITz-6) – TEVseq

<400> 5
ggacgcaccc cacccagcct gggtccccaa gatgagtcct gcaccaccgc cagctcctcc      60

ctggccaagg acacttcatc gcttcaactt cctcctcttg aacgtcttac tctcggtggc     120

tctggaggtc tcgagggaat gaatggagct ataggaggtg accttttgct caattttcct     180

gacatgtcgg tcctagagcg ccaaagggct cacctcaagt acctcaatcc cacctttgat     240

tctcctctcg ccggcttctt tgccgattct tcaatgatta ccggcggcga gatggacagc     300

tatctttcga ctgccggttt gaatcttccg atgatgtacg gtgagacgac ggtggaaggt     360

gattcaagac tctcaatttc gccggaaacg acgcttggga ctggaaattt caaggcagcg     420

aagtttgata cagagactaa ggattgtaat gaggcggcga agaagatgac gatgaacaga     480

gatgacctag tagaagaagg agaagaagag aagtcgaaaa taacagagca aaacaatggg     540

agcacaaaaa gcatcaagaa gatgaaacac aaagccaaga aagaagagaa caatttctct     600

aatgattcat ctaaagtgac gaaggaattg gagaaaacgg attatattca tgcatgcggt     660

agtggtagtg gggagtttct ggcaaccaca ctggaacgga tcgagaaaaa tttcgtgatt     720

actgatccga gactgcctga caacccaatc atttttgcga gcgattcctt cctgcagctg     780

acagaatatt ctcgggaaga gatcctgggg cgcaattgcc gttttctgca gggacccgag     840

acagaccgtg ccactgttcg gaaaatcaga gatgctattg acaaccagac tgaagtgacc     900

gttcagctga tcaattatac caagagcggc aagaagttct ggaacgtgtt ccacctgcag     960

ccgatgcgcg attataaggg cgacgtccag tacttcattg gcgtgcagct ggatggcacc    1020

gaacgtcttc atggcgccgc tgagcgtgag gcggtctgcc tgatcaaaaa gacagccttt    1080

cagattgctg agaacctgta cttccagggc                                     1110


<210> 6
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2tail – CIBN – AsLOV2(BLITz-6) – TEVseq

<400> 6
Gly Arg Thr Pro Pro Ser Leu Gly Pro Gln Asp Glu Ser Cys Thr Thr 
1               5                   10                  15      
Ala Ser Ser Ser Leu Ala Lys Asp Thr Ser Ser Leu Gln Leu Pro Pro 
            20                  25                  30          
Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly Leu Glu Gly Met Asn 
        35                  40                  45              
Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met Ser Val 
    50                  55                  60                  
Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr Phe Asp 
65                  70                  75                  80  
Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr Gly Gly 
                85                  90                  95      
Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro Met Met 
            100                 105                 110         
Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile Ser Pro 
        115                 120                 125             
Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Ala Ala Lys Phe Asp Thr 
    130                 135                 140                 
Glu Thr Lys Asp Cys Asn Glu Ala Ala Lys Lys Met Thr Met Asn Arg 
145                 150                 155                 160 
Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile Thr Glu 
                165                 170                 175     
Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His Lys Ala 
            180                 185                 190         
Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val Thr Lys 
        195                 200                 205             
Glu Leu Glu Lys Thr Asp Tyr Ile His Ala Cys Gly Ser Gly Ser Gly 
    210                 215                 220                 
Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile 
225                 230                 235                 240 
Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser 
                245                 250                 255     
Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         
Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys 
        275                 280                 285             
Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile 
    290                 295                 300                 
Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe His Leu Gln 
305                 310                 315                 320 
Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln 
                325                 330                 335     
Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg Glu Ala Val 
            340                 345                 350         
Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile Glu Asn Leu Tyr Phe Gln 
        355                 360                 365             
Gly 
    

<210> 7
<211> 801
<212> DNA
<213> Artificial Sequence

<220> 
<223> Backbone Sequence A

<400> 7
aagctttcat ttaggtgaca ctatagaata caagctactt gttctatgga gacagacaca      60

ctcctgctat gggtactgct gctctgggtt ccaggttcca ctggtgacga acaaaaactc     120

atctcagaag aggatctgaa tgctgtgggc caggacacgc aggaggtcat cgtggtgcca     180

cactccttgc cctttaaggt ggtggtgatc tcagccatcc tggccctggt ggtgctcacc     240

atcatctccc ttatcatcct catcatgctt tggcagaaga agccacgtgg tggctctgga     300

ggtctcgagg gagcatgcgg tggcggtggc tctggaggtg gtgggtccgg aggaggcggc     360

cgctccggtg gatccatgct tcaacttcct cctcttgaac gtcttactct cgagatgggc     420

gagagcctgt tcaagggacc tagggactac aaccctatca gtagcacaat ttgtcacctg     480

accaacgaga gtgatggcca cacaacaagc ctgtacggca tcgggttcgg accctttatc     540

atcaccaaca agcacctgtt caggcggaat aatggcactc tgctggtgca gagcctgcac     600

ggggtgttca aagtgaagaa cacaaccact ctgcagcagc acctgatcga tgggcgggat     660

atgatcatca ttaggatgcc caaggacttc cccccttttc ctcagaaact gaagttccga     720

gagccccaga gagaggagag aatctgtctg gtgaccacaa actttcagga gctcggtagt     780

ggtagtgggt ctagagctag c                                               801


<210> 8
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> CaM – TEV-N – AsLOV2(BLITz-6)– TEVseq

<400> 8
atgccggacc aactgactga agagcagatc gcagaattta aagaggcttt ctccctattt      60

gacaaggacg gggatgggac aataacaacc aaggagctgg ggacggtgat gcggtctctg     120

gggcagaacc ccacagaagc agagctgcaa gacatgatca atgaagtaga tgccgacggt     180

gacggcacaa tcgacttccc tgagttcctg acaatgatgg caagaaaaat gaaatacagg     240

gacacggaag aagaaattag agaagcgttc ggtgtgtttg ataaggatgg caatggctac     300

atcagtgcag cagagcttcg ccacgtgatg acaaaccttg gagagaagtt aacagatgaa     360

gaggttgatg aaatgatcag ggaagcagac atcgatgggg atggtcaggt aaactacgaa     420

gagtttgtac aaatgatgac agcgaaggca tgcggtggcg gtggctctgg aggtggtggg     480

tccggaggag gcggccgcat gggcgagagc ctgttcaagg gacctaggga ctacaaccct     540

atcagtagca caatttgtca cctgaccaac gagagtgatg gccacacaac aagcctgtac     600

ggcatcgggt tcggaccctt tatcatcacc aacaagcacc tgttcaggcg gaataatggc     660

actctgctgg tgcagagcct gcacggggtg ttcaaagtga agaacacaac cactctgcag     720

cagcacctga tcgatgggcg ggatatgatc atcattagga tgcccaagga cttcccccct     780

tttcctcaga aactgaagtt ccgagagccc cagagagagg agagaatctg tctggtgacc     840

acaaactttc aggagctcgg tagtggtagt ggggagtttc tggcaaccac actggaacgg     900

atcgagaaaa atttcgtgat tactgatccg agactgcctg acaacccaat catttttgcg     960

agcgattcct tcctgcagct gacagaatat tctcgggaag agatcctggg gcgcaattgc    1020

cgttttctgc agggacccga gacagaccgt gccactgttc ggaaaatcag agatgctatt    1080

gacaaccaga ctgaagtgac cgttcagctg atcaattata ccaagagcgg caagaagttc    1140

tggaacgtgt tccacctgca gccgatgcgc gattataagg gcgacgtcca gtacttcatt    1200

ggcgtgcagc tggatggcac cgaacgtctt catggcgccg ctgagcgtga ggcggtctgc    1260

ctgatcaaaa agacagcctt tcagattgag aacctgtact tccagggc                 1308


<210> 9
<211> 436
<212> PRT
<213> Artificial Sequence

<220> 
<223> CaM – TEV-N – AsLOV2(BLITz-6)– TEVseq

<400> 9
Met Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      
Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          
Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              
Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile 
    50                  55                  60                  
Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr Arg 
65                  70                  75                  80  
Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys Asp 
                85                  90                  95      
Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         
Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             
Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 
Met Met Thr Ala Lys Ala Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Gly Gly Gly Gly Arg Met Gly Glu Ser Leu Phe Lys Gly Pro Arg 
                165                 170                 175     
Asp Tyr Asn Pro Ile Ser Ser Thr Ile Cys His Leu Thr Asn Glu Ser 
            180                 185                 190         
Asp Gly His Thr Thr Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile 
        195                 200                 205             
Ile Thr Asn Lys His Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu Val 
    210                 215                 220                 
Gln Ser Leu His Gly Val Phe Lys Val Lys Asn Thr Thr Thr Leu Gln 
225                 230                 235                 240 
Gln His Leu Ile Asp Gly Arg Asp Met Ile Ile Ile Arg Met Pro Lys 
                245                 250                 255     
Asp Phe Pro Pro Phe Pro Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg 
            260                 265                 270         
Glu Glu Arg Ile Cys Leu Val Thr Thr Asn Phe Gln Glu Leu Gly Ser 
        275                 280                 285             
Gly Ser Gly Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn 
    290                 295                 300                 
Phe Val Ile Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala 
305                 310                 315                 320 
Ser Asp Ser Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu 
                325                 330                 335     
Gly Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr 
            340                 345                 350         
Val Arg Lys Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val 
        355                 360                 365             
Gln Leu Ile Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe 
    370                 375                 380                 
His Leu Gln Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile 
385                 390                 395                 400 
Gly Val Gln Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg 
                405                 410                 415     
Glu Ala Val Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile Glu Asn Leu 
            420                 425                 430         
Tyr Phe Gln Gly 
        435     

<210> 10
<211> 1002
<212> DNA
<213> Artificial Sequence

<220> 
<223> TetR-VP16

<400> 10
tctagattag ataaaagtaa agtgattaac agcgcattag agctgcttaa tgaggtcgga      60

atcgaaggtt taacaacccg taaactcgcc cagaagctag gtgtagagca gcctacattg     120

tattggcatg taaaaaataa gcgggctttg ctcgacgcct tagccattga gatgttagat     180

aggcaccata ctcacttttg ccctttagaa ggggaaagct ggcaagattt tttacgtaat     240

aacgctaaaa gttttagatg tgctttacta agtcatcgcg atggagcaaa agtacattta     300

ggtacacggc ctacagaaaa acagtatgaa actctcgaaa atcaattagc ctttttatgc     360

caacaaggtt tttcactaga gaatgcatta tatgcactca gcgctgtggg gcattttact     420

ttaggttgcg tattggaaga tcaagagcat caagtcgcta aagaagaaag ggaaacacct     480

actactgata gtatgccgcc attattacga caagctatcg aattatttga tcaccaaggt     540

gcagagccag ccttcttatt cggccttgaa ttgatcatat gcggattaga aaaacaactt     600

aaatgtgaaa gtgggtccgc gtacagccgc gcgcgtacga aaaacaatta cgggtctacc     660

atcgagggcc tgctcgatct cccggacgac gacgcccccg aagaggcggg gctggcggct     720

ccgcgcctgt cctttctccc cgcgggacac acgcgcagac tgtcgacggc ccccccgacc     780

gatgtcagcc tgggggacga gctccactta gacggcgagg acgtggcgat ggcgcatgcc     840

gacgcgctag acgatttcga tctggacatg ttgggggacg gggattcccc gggtccggga     900

tttacccccc acgactccgc cccctacggc gctctggata tggccgactt cgagtttgag     960

cagatgttta ccgatgccct tggaattgac gagtacggtg gg                       1002


<210> 11
<211> 334
<212> PRT
<213> Artificial Sequence

<220> 
<223> TetR-VP16

<400> 11
Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu 
1               5                   10                  15      
Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys 
            20                  25                  30          
Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg 
        35                  40                  45              
Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr 
    50                  55                  60                  
His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn 
65                  70                  75                  80  
Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala 
                85                  90                  95      
Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu 
            100                 105                 110         
Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn 
        115                 120                 125             
Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val 
    130                 135                 140                 
Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro 
145                 150                 155                 160 
Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe 
                165                 170                 175     
Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile 
            180                 185                 190         
Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala Tyr 
        195                 200                 205             
Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu 
    210                 215                 220                 
Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala 
225                 230                 235                 240 
Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr 
                245                 250                 255     
Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly 
            260                 265                 270         
Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu 
        275                 280                 285             
Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His 
    290                 295                 300                 
Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu 
305                 310                 315                 320 
Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                325                 330                 

<210> 12
<211> 4101
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cas9

<400> 12
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga c                                               4101


<210> 13
<211> 1367
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cas9

<400> 13
Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      
Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          
Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              
Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  
Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  
Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      
Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         
Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             
Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 
Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 
Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     
Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         
Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             
Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 
Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 
Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     
Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         
Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             
Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 
Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 
Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     
Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         
Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             
Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 
Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 
Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     
Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         
Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             
Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 
Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 
Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     
Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         
Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             
Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 
Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 
Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     
Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         
Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             
Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 
Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 
Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     
Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         
Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             
Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 
Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 
Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     
Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         
His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             
Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 
Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 
Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     
Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         
Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             
Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 
Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 
Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     
Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         
Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             
His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 
Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 
Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     
Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         
Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val 
        995                 1000                1005            
Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser 
    1010                1015                1020                
Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn 
1025                1030                1035                1040
Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile 
                1045                1050                1055    
Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val 
            1060                1065                1070        
Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met 
        1075                1080                1085            
Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe 
    1090                1095                1100                
Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala 
1105                1110                1115                1120
Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro 
                1125                1130                1135    
Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys 
            1140                1145                1150        
Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met 
        1155                1160                1165            
Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys 
    1170                1175                1180                
Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr 
1185                1190                1195                1200
Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 
                1205                1210                1215    
Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 
            1220                1225                1230        
Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 
        1235                1240                1245            
Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 
    1250                1255                1260                
Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile 
1265                1270                1275                1280
Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 
                1285                1290                1295    
Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe 
            1300                1305                1310        
Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr 
        1315                1320                1325            
Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala 
    1330                1335                1340                
Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 
1345                1350                1355                1360
Leu Ser Gln Leu Gly Gly Asp 
                1365        

<210> 14
<211> 1032
<212> DNA
<213> Artificial Sequence

<220> 
<223> CRE recombinase

<400> 14
atggccaatt tactgaccgt acaccaaaat ttgcctgcat taccggtcga tgcaacgagt      60

gatgaggttc gcaagaacct gatggacatg ttcagggatc gccaggcgtt ttctgagcat     120

acctggaaaa tgcttctgtc cgtttgccgg tcgtgggcgg catggtgcaa gttgaataac     180

cggaaatggt ttcccgcaga acctgaagat gttcgcgatt atcttctata tcttcaggcg     240

cgcggtctgg cagtaaaaac tatccagcaa catttgggcc agctaaacat gcttcatcgt     300

cggtccgggc tgccacgacc aagtgacagc aatgctgttt cactggttat gcggcggatc     360

cgaaaagaaa acgttgatgc cggtgaacgt gcaaaacagg ctctagcgtt cgaacgcact     420

gatttcgacc aggttcgttc actcatggaa aatagcgatc gctgccagga tatacgtaat     480

ctggcatttc tggggattgc ttataacacc ctgttacgta tagccgaaat tgccaggatc     540

agggttaaag atatctcacg tactgacggt gggagaatgt taatccatat tggcagaacg     600

aaaacgctgg ttagcaccgc aggtgtagag aaggcactta gcctgggggt aactaaactg     660

gtcgagcgat ggatttccgt ctctggtgta gctgatgatc cgaataacta cctgttttgc     720

cgggtcagaa aaaatggtgt tgccgcgcca tctgccacca gccagctatc aactcgcgcc     780

ctggaaggga tttttgaagc aactcatcga ttgatttacg gcgctaagga tgactctggt     840

cagagatacc tggcctggtc tggacacagt gcccgtgtcg gagccgcgcg agatatggcc     900

cgcgctggag tttcaatacc ggagatcatg caagctggtg gctggaccaa tgtaaatatt     960

gtcatgaact atatccgtaa cctggatagt gaaacagggg caatggtgcg cctgctggaa    1020

gatggcgatt aa                                                        1032


<210> 15
<211> 343
<212> PRT
<213> Artificial Sequence

<220> 
<223> CRE recombinase

<400> 15
Met Ala Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      
Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          
Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              
Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  
Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  
Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      
Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         
Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             
Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 
Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 
Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     
Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         
Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             
Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 
Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 
Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     
Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         
Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             
His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 
Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 
Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     
Arg Leu Leu Glu Asp Gly Asp 
            340             

<210> 16
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> CIBN – TEV-N – AsLOV2 – TEVseq – TetR-VP16(tTA)

<400> 16
atgaatggag ctataggagg tgaccttttg ctcaattttc ctgacatgtc ggtcctagag      60

cgccaaaggg ctcacctcaa gtacctcaat cccacctttg attctcctct cgccggcttc     120

tttgccgatt cttcaatgat taccggcggc gagatggaca gctatctttc gactgccggt     180

ttgaatcttc cgatgatgta cggtgagacg acggtggaag gtgattcaag actctcaatt     240

tcgccggaaa cgacgcttgg gactggaaat ttcaaggcag cgaagtttga tacagagact     300

aaggattgta atgaggcggc gaagaagatg acgatgaaca gagatgacct agtagaagaa     360

ggagaagaag agaagtcgaa aataacagag caaaacaatg ggagcacaaa aagcatcaag     420

aagatgaaac acaaagccaa gaaagaagag aacaatttct ctaatgattc atctaaagtg     480

acgaaggaat tggagaaaac ggattatatt catgcatgcg gtggcggtgg ctctggaggt     540

ggtgggtccg gaggaggcgg ccgctccggt ggatccatgc ttcaacttcc tcctcttgaa     600

cgtcttactc tcgagatggg cgagagcctg ttcaagggac ctagggacta caaccctatc     660

agtagcacaa tttgtcacct gaccaacgag agtgatggcc acacaacaag cctgtacggc     720

atcgggttcg gaccctttat catcaccaac aagcacctgt tcaggcggaa taatggcact     780

ctgctggtgc agagcctgca cggggtgttc aaagtgaaga acacaaccac tctgcagcag     840

cacctgatcg atgggcggga tatgatcatc attaggatgc ccaaggactt cccccctttt     900

cctcagaaac tgaagttccg agagccccag agagaggaga gaatctgtct ggtgaccaca     960

aactttcagg agctcggtag tggtagtggg gagtttctgg caaccacact ggaacggatc    1020

gagaaaaatt tcgtgattac tgatccgaga ctgcctgaca acccaatcat ttttgcgagc    1080

gattccttcc tgcagctgac agaatattct cgggaagaga tcctggggcg caattgccgt    1140

tttctgcagg gacccgagac agaccgtgcc actgttcgga aaatcagaga tgctattgac    1200

aaccagactg aagtgaccgt tcagctgatc aattatacca agagcggcaa gaagttctgg    1260

aacgtgttcc acctgcagcc gatgcgcgat tataagggcg acgtccagta cttcattggc    1320

gtgcagctgg atggcaccga acgtcttcat ggcgccgctg agcgtgaggc ggtctgcctg    1380

atcaaaaaga cagcctttca gattgctgag aacctgtact tccagggctc tagattagat    1440

aaaagtaaag tgattaacag cgcattagag ctgcttaatg aggtcggaat cgaaggttta    1500

acaacccgta aactcgccca gaagctaggt gtagagcagc ctacattgta ttggcatgta    1560

aaaaataagc gggctttgct cgacgcctta gccattgaga tgttagatag gcaccatact    1620

cacttttgcc ctttagaagg ggaaagctgg caagattttt tacgtaataa cgctaaaagt    1680

tttagatgtg ctttactaag tcatcgcgat ggagcaaaag tacatttagg tacacggcct    1740

acagaaaaac agtatgaaac tctcgaaaat caattagcct ttttatgcca acaaggtttt    1800

tcactagaga atgcattata tgcactcagc gctgtggggc attttacttt aggttgcgta    1860

ttggaagatc aagagcatca agtcgctaaa gaagaaaggg aaacacctac tactgatagt    1920

atgccgccat tattacgaca agctatcgaa ttatttgatc accaaggtgc agagccagcc    1980

ttcttattcg gccttgaatt gatcatatgc ggattagaaa aacaacttaa atgtgaaagt    2040

gggtccgcgt acagccgcgc gcgtacgaaa aacaattacg ggtctaccat cgagggcctg    2100

ctcgatctcc cggacgacga cgcccccgaa gaggcggggc tggcggctcc gcgcctgtcc    2160

tttctccccg cgggacacac gcgcagactg tcgacggccc ccccgaccga tgtcagcctg    2220

ggggacgagc tccacttaga cggcgaggac gtggcgatgg cgcatgccga cgcgctagac    2280

gatttcgatc tggacatgtt gggggacggg gattccccgg gtccgggatt taccccccac    2340

gactccgccc cctacggcgc tctggatatg gccgacttcg agtttgagca gatgtttacc    2400

gatgcccttg gaattgacga gtacggtggg tag                                 2433


<210> 17
<211> 810
<212> PRT
<213> Artificial Sequence

<220> 
<223> CIBN – TEV-N – AsLOV2 – TEVseq – TetR-VP16(tTA)

<400> 17
Met Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met 
1               5                   10                  15      
Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr 
            20                  25                  30          
Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr 
        35                  40                  45              
Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro 
    50                  55                  60                  
Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile 
65                  70                  75                  80  
Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Ala Ala Lys Phe 
                85                  90                  95      
Asp Thr Glu Thr Lys Asp Cys Asn Glu Ala Ala Lys Lys Met Thr Met 
            100                 105                 110         
Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile 
        115                 120                 125             
Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His 
    130                 135                 140                 
Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val 
145                 150                 155                 160 
Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Ala Cys Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Ser Gly Gly Ser 
            180                 185                 190         
Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Glu Met Gly Glu 
        195                 200                 205             
Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
    210                 215                 220                 
Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
225                 230                 235                 240 
Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
                245                 250                 255     
Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
            260                 265                 270         
Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
        275                 280                 285             
Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
    290                 295                 300                 
Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
305                 310                 315                 320 
Asn Phe Gln Glu Leu Gly Ser Gly Ser Gly Glu Phe Leu Ala Thr Thr 
                325                 330                 335     
Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp Pro Arg Leu Pro 
            340                 345                 350         
Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu Gln Leu Thr Glu 
        355                 360                 365             
Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg Phe Leu Gln Gly 
    370                 375                 380                 
Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg Asp Ala Ile Asp 
385                 390                 395                 400 
Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr Thr Lys Ser Gly 
                405                 410                 415     
Lys Lys Phe Trp Asn Val Phe His Leu Gln Pro Met Arg Asp Tyr Lys 
            420                 425                 430         
Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp Gly Thr Glu Arg 
        435                 440                 445             
Leu His Gly Ala Ala Glu Arg Glu Ala Val Cys Leu Ile Lys Lys Thr 
    450                 455                 460                 
Ala Phe Gln Ile Ala Glu Asn Leu Tyr Phe Gln Gly Ser Arg Leu Asp 
465                 470                 475                 480 
Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly 
                485                 490                 495     
Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu 
            500                 505                 510         
Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp 
        515                 520                 525             
Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro 
    530                 535                 540                 
Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser 
545                 550                 555                 560 
Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu 
                565                 570                 575     
Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu 
            580                 585                 590         
Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala 
        595                 600                 605             
Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln 
    610                 615                 620                 
Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser 
625                 630                 635                 640 
Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly 
                645                 650                 655     
Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu 
            660                 665                 670         
Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala Tyr Ser Arg Ala Arg 
        675                 680                 685             
Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro 
    690                 695                 700                 
Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala Pro Arg Leu Ser 
705                 710                 715                 720 
Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr Ala Pro Pro Thr 
                725                 730                 735     
Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala 
            740                 745                 750         
Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        755                 760                 765             
Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro 
    770                 775                 780                 
Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr 
785                 790                 795                 800 
Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                805                 810 

<210> 18
<211> 1953
<212> DNA
<213> Artificial Sequence

<220> 
<223> V2tail – TEV-N – AsLOV2 –TEVseq – TetR-VP16(tTA)

<400> 18
ggacgcaccc cacccagcct gggtccccaa gatgagtcct gcaccaccgc cagctcctcc      60

ctggccaagg acacttcatc gcttcaactt cctcctcttg aacgtcttac tctcggtggc     120

tctggaggtc tcgagatggg cgagagcctg ttcaagggac ctagggacta caaccctatc     180

agtagcacaa tttgtcacct gaccaacgag agtgatggcc acacaacaag cctgtacggc     240

atcgggttcg gaccctttat catcaccaac aagcacctgt tcaggcggaa taatggcact     300

ctgctggtgc agagcctgca cggggtgttc aaagtgaaga acacaaccac tctgcagcag     360

cacctgatcg atgggcggga tatgatcatc attaggatgc ccaaggactt cccccctttt     420

cctcagaaac tgaagttccg agagccccag agagaggaga gaatctgtct ggtgaccaca     480

aactttcagg agctcggtag tggtagtggg gagtttctgg caaccacact ggaacggatc     540

gagaaaaatt tcgtgattac tgatccgaga ctgcctgaca acccaatcat ttttgcgagc     600

gattccttcc tgcagctgac agaatattct cgggaagaga tcctggggcg caattgccgt     660

tttctgcagg gacccgagac agaccgtgcc actgttcgga aaatcagaga tgctattgac     720

aaccagactg aagtgaccgt tcagctgatc aattatacca agagcggcaa gaagttctgg     780

aacgtgttcc acctgcagcc gatgcgcgat tataagggcg acgtccagta cttcattggc     840

gtgcagctgg atggcaccga acgtcttcat ggcgccgctg agcgtgaggc ggtctgcctg     900

atcaaaaaga cagcctttca gattgctgag aacctgtact tccagggctc tagattagat     960

aaaagtaaag tgattaacag cgcattagag ctgcttaatg aggtcggaat cgaaggttta    1020

acaacccgta aactcgccca gaagctaggt gtagagcagc ctacattgta ttggcatgta    1080

aaaaataagc gggctttgct cgacgcctta gccattgaga tgttagatag gcaccatact    1140

cacttttgcc ctttagaagg ggaaagctgg caagattttt tacgtaataa cgctaaaagt    1200

tttagatgtg ctttactaag tcatcgcgat ggagcaaaag tacatttagg tacacggcct    1260

acagaaaaac agtatgaaac tctcgaaaat caattagcct ttttatgcca acaaggtttt    1320

tcactagaga atgcattata tgcactcagc gctgtggggc attttacttt aggttgcgta    1380

ttggaagatc aagagcatca agtcgctaaa gaagaaaggg aaacacctac tactgatagt    1440

atgccgccat tattacgaca agctatcgaa ttatttgatc accaaggtgc agagccagcc    1500

ttcttattcg gccttgaatt gatcatatgc ggattagaaa aacaacttaa atgtgaaagt    1560

gggtccgcgt acagccgcgc gcgtacgaaa aacaattacg ggtctaccat cgagggcctg    1620

ctcgatctcc cggacgacga cgcccccgaa gaggcggggc tggcggctcc gcgcctgtcc    1680

tttctccccg cgggacacac gcgcagactg tcgacggccc ccccgaccga tgtcagcctg    1740

ggggacgagc tccacttaga cggcgaggac gtggcgatgg cgcatgccga cgcgctagac    1800

gatttcgatc tggacatgtt gggggacggg gattccccgg gtccgggatt taccccccac    1860

gactccgccc cctacggcgc tctggatatg gccgacttcg agtttgagca gatgtttacc    1920

gatgcccttg gaattgacga gtacggtggg tag                                 1953


<210> 19
<211> 650
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2tail – TEV-N – AsLOV2 –TEVseq – TetR-VP16(tTA)

<400> 19
Gly Arg Thr Pro Pro Ser Leu Gly Pro Gln Asp Glu Ser Cys Thr Thr 
1               5                   10                  15      
Ala Ser Ser Ser Leu Ala Lys Asp Thr Ser Ser Leu Gln Leu Pro Pro 
            20                  25                  30          
Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly Leu Glu Met Gly Glu 
        35                  40                  45              
Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
    50                  55                  60                  
Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
65                  70                  75                  80  
Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
                85                  90                  95      
Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
            100                 105                 110         
Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
        115                 120                 125             
Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
    130                 135                 140                 
Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
145                 150                 155                 160 
Asn Phe Gln Glu Leu Gly Ser Gly Ser Gly Glu Phe Leu Ala Thr Thr 
                165                 170                 175     
Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp Pro Arg Leu Pro 
            180                 185                 190         
Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu Gln Leu Thr Glu 
        195                 200                 205             
Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg Phe Leu Gln Gly 
    210                 215                 220                 
Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg Asp Ala Ile Asp 
225                 230                 235                 240 
Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr Thr Lys Ser Gly 
                245                 250                 255     
Lys Lys Phe Trp Asn Val Phe His Leu Gln Pro Met Arg Asp Tyr Lys 
            260                 265                 270         
Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp Gly Thr Glu Arg 
        275                 280                 285             
Leu His Gly Ala Ala Glu Arg Glu Ala Val Cys Leu Ile Lys Lys Thr 
    290                 295                 300                 
Ala Phe Gln Ile Ala Glu Asn Leu Tyr Phe Gln Gly Ser Arg Leu Asp 
305                 310                 315                 320 
Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly 
                325                 330                 335     
Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu 
            340                 345                 350         
Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp 
        355                 360                 365             
Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro 
    370                 375                 380                 
Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser 
385                 390                 395                 400 
Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu 
                405                 410                 415     
Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu 
            420                 425                 430         
Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala 
        435                 440                 445             
Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln 
    450                 455                 460                 
Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser 
465                 470                 475                 480 
Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly 
                485                 490                 495     
Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu 
            500                 505                 510         
Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala Tyr Ser Arg Ala Arg 
        515                 520                 525             
Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro 
    530                 535                 540                 
Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala Pro Arg Leu Ser 
545                 550                 555                 560 
Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr Ala Pro Pro Thr 
                565                 570                 575     
Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala 
            580                 585                 590         
Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        595                 600                 605             
Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro 
    610                 615                 620                 
Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr 
625                 630                 635                 640 
Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                645                 650 

<210> 20
<211> 2112
<212> DNA
<213> Artificial Sequence

<220> 
<223> V2tail – CIBN – AsLOV2 – TEVseq – TetR-VP16(tTA)

<400> 20
ggacgcaccc cacccagcct gggtccccaa gatgagtcct gcaccaccgc cagctcctcc      60

ctggccaagg acacttcatc gcttcaactt cctcctcttg aacgtcttac tctcggtggc     120

tctggaggtc tcgagatgaa tggagctata ggaggtgacc ttttgctcaa ttttcctgac     180

atgtcggtcc tagagcgcca aagggctcac ctcaagtacc tcaatcccac ctttgattct     240

cctctcgccg gcttctttgc cgattcttca atgattaccg gcggcgagat ggacagctat     300

ctttcgactg ccggtttgaa tcttccgatg atgtacggtg agacgacggt ggaaggtgat     360

tcaagactct caatttcgcc ggaaacgacg cttgggactg gaaatttcaa ggcagcgaag     420

tttgatacag agactaagga ttgtaatgag gcggcgaaga agatgacgat gaacagagat     480

gacctagtag aagaaggaga agaagagaag tcgaaaataa cagagcaaaa caatgggagc     540

acaaaaagca tcaagaagat gaaacacaaa gccaagaaag aagagaacaa tttctctaat     600

gattcatcta aagtgacgaa ggaattggag aaaacggatt atattcatga gctcggtagt     660

ggtagtgggg agtttctggc aaccacactg gaacggatcg agaaaaattt cgtgattact     720

gatccgagac tgcctgacaa cccaatcatt tttgcgagcg attccttcct gcagctgaca     780

gaatattctc gggaagagat cctggggcgc aattgccgtt ttctgcaggg acccgagaca     840

gaccgtgcca ctgttcggaa aatcagagat gctattgaca accagactga agtgaccgtt     900

cagctgatca attataccaa gagcggcaag aagttctgga acgtgttcca cctgcagccg     960

atgcgcgatt ataagggcga cgtccagtac ttcattggcg tgcagctgga tggcaccgaa    1020

cgtcttcatg gcgccgctga gcgtgaggcg gtctgcctga tcaaaaagac agcctttcag    1080

attgctgaga acctgtactt ccagggctct agattagata aaagtaaagt gattaacagc    1140

gcattagagc tgcttaatga ggtcggaatc gaaggtttaa caacccgtaa actcgcccag    1200

aagctaggtg tagagcagcc tacattgtat tggcatgtaa aaaataagcg ggctttgctc    1260

gacgccttag ccattgagat gttagatagg caccatactc acttttgccc tttagaaggg    1320

gaaagctggc aagatttttt acgtaataac gctaaaagtt ttagatgtgc tttactaagt    1380

catcgcgatg gagcaaaagt acatttaggt acacggccta cagaaaaaca gtatgaaact    1440

ctcgaaaatc aattagcctt tttatgccaa caaggttttt cactagagaa tgcattatat    1500

gcactcagcg ctgtggggca ttttacttta ggttgcgtat tggaagatca agagcatcaa    1560

gtcgctaaag aagaaaggga aacacctact actgatagta tgccgccatt attacgacaa    1620

gctatcgaat tatttgatca ccaaggtgca gagccagcct tcttattcgg ccttgaattg    1680

atcatatgcg gattagaaaa acaacttaaa tgtgaaagtg ggtccgcgta cagccgcgcg    1740

cgtacgaaaa acaattacgg gtctaccatc gagggcctgc tcgatctccc ggacgacgac    1800

gcccccgaag aggcggggct ggcggctccg cgcctgtcct ttctccccgc gggacacacg    1860

cgcagactgt cgacggcccc cccgaccgat gtcagcctgg gggacgagct ccacttagac    1920

ggcgaggacg tggcgatggc gcatgccgac gcgctagacg atttcgatct ggacatgttg    1980

ggggacgggg attccccggg tccgggattt accccccacg actccgcccc ctacggcgct    2040

ctggatatgg ccgacttcga gtttgagcag atgtttaccg atgcccttgg aattgacgag    2100

tacggtgggt ag                                                        2112


<210> 21
<211> 703
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2tail – CIBN – AsLOV2 – TEVseq – TetR-VP16(tTA)

<400> 21
Gly Arg Thr Pro Pro Ser Leu Gly Pro Gln Asp Glu Ser Cys Thr Thr 
1               5                   10                  15      
Ala Ser Ser Ser Leu Ala Lys Asp Thr Ser Ser Leu Gln Leu Pro Pro 
            20                  25                  30          
Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly Leu Glu Met Asn Gly 
        35                  40                  45              
Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met Ser Val Leu 
    50                  55                  60                  
Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr Phe Asp Ser 
65                  70                  75                  80  
Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr Gly Gly Glu 
                85                  90                  95      
Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro Met Met Tyr 
            100                 105                 110         
Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile Ser Pro Glu 
        115                 120                 125             
Thr Thr Leu Gly Thr Gly Asn Phe Lys Ala Ala Lys Phe Asp Thr Glu 
    130                 135                 140                 
Thr Lys Asp Cys Asn Glu Ala Ala Lys Lys Met Thr Met Asn Arg Asp 
145                 150                 155                 160 
Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile Thr Glu Gln 
                165                 170                 175     
Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His Lys Ala Lys 
            180                 185                 190         
Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val Thr Lys Glu 
        195                 200                 205             
Leu Glu Lys Thr Asp Tyr Ile His Glu Leu Gly Ser Gly Ser Gly Glu 
    210                 215                 220                 
Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr 
225                 230                 235                 240 
Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe 
                245                 250                 255     
Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys 
            260                 265                 270         
Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile 
        275                 280                 285             
Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn 
    290                 295                 300                 
Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe His Leu Gln Pro 
305                 310                 315                 320 
Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu 
                325                 330                 335     
Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg Glu Ala Val Cys 
            340                 345                 350         
Leu Ile Lys Lys Thr Ala Phe Gln Ile Ala Glu Asn Leu Tyr Phe Gln 
        355                 360                 365             
Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
    370                 375                 380                 
Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
385                 390                 395                 400 
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
                405                 410                 415     
Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
            420                 425                 430         
Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
        435                 440                 445             
Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
    450                 455                 460                 
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
465                 470                 475                 480 
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
                485                 490                 495     
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
            500                 505                 510         
Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
        515                 520                 525             
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
    530                 535                 540                 
Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
545                 550                 555                 560 
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala 
                565                 570                 575     
Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly 
            580                 585                 590         
Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala 
        595                 600                 605             
Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser 
    610                 615                 620                 
Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp 
625                 630                 635                 640 
Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp 
                645                 650                 655     
Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro 
            660                 665                 670         
His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe 
        675                 680                 685             
Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
    690                 695                 700             

<210> 22
<211> 2319
<212> DNA
<213> Artificial Sequence

<220> 
<223> CaM – TEV-N – AsLOV2 –TEVseq – TetR-VP16(tTA)

<400> 22
atgccggacc aactgactga agagcagatc gcagaattta aagaggcttt ctccctattt      60

gacaaggacg gggatgggac aataacaacc aaggagctgg ggacggtgat gcggtctctg     120

gggcagaacc ccacagaagc agagctgcaa gacatgatca atgaagtaga tgccgacggt     180

gacggcacaa tcgacttccc tgagttcctg acaatgatgg caagaaaaat gaaatacagg     240

gacacggaag aagaaattag agaagcgttc ggtgtgtttg ataaggatgg caatggctac     300

atcagtgcag cagagcttcg ccacgtgatg acaaaccttg gagagaagtt aacagatgaa     360

gaggttgatg aaatgatcag ggaagcagac atcgatgggg atggtcaggt aaactacgaa     420

gagtttgtac aaatgatgac agcgaagctt caacttcctc ctcttgaacg tcttactctc     480

ggtggctctg gaggtctcga gatgggcgag agcctgttca agggacctag ggactacaac     540

cctatcagta gcacaatttg tcacctgacc aacgagagtg atggccacac aacaagcctg     600

tacggcatcg ggttcggacc ctttatcatc accaacaagc acctgttcag gcggaataat     660

ggcactctgc tggtgcagag cctgcacggg gtgttcaaag tgaagaacac aaccactctg     720

cagcagcacc tgatcgatgg gcgggatatg atcatcatta ggatgcccaa ggacttcccc     780

ccttttcctc agaaactgaa gttccgagag ccccagagag aggagagaat ctgtctggtg     840

accacaaact ttcaggagct cggtagtggt agtggggagt ttctggcaac cacactggaa     900

cggatcgaga aaaatttcgt gattactgat ccgagactgc ctgacaaccc aatcattttt     960

gcgagcgatt ccttcctgca gctgacagaa tattctcggg aagagatcct ggggcgcaat    1020

tgccgttttc tgcagggacc cgagacagac cgtgccactg ttcggaaaat cagagatgct    1080

attgacaacc agactgaagt gaccgttcag ctgatcaatt ataccaagag cggcaagaag    1140

ttctggaacg tgttccacct gcagccgatg cgcgattata agggcgacgt ccagtacttc    1200

attggcgtgc agctggatgg caccgaacgt cttcatggcg ccgctgagcg tgaggcggtc    1260

tgcctgatca aaaagacagc ctttcagatt gctgagaacc tgtacttcca gggctctaga    1320

ttagataaaa gtaaagtgat taacagcgca ttagagctgc ttaatgaggt cggaatcgaa    1380

ggtttaacaa cccgtaaact cgcccagaag ctaggtgtag agcagcctac attgtattgg    1440

catgtaaaaa ataagcgggc tttgctcgac gccttagcca ttgagatgtt agataggcac    1500

catactcact tttgcccttt agaaggggaa agctggcaag attttttacg taataacgct    1560

aaaagtttta gatgtgcttt actaagtcat cgcgatggag caaaagtaca tttaggtaca    1620

cggcctacag aaaaacagta tgaaactctc gaaaatcaat tagccttttt atgccaacaa    1680

ggtttttcac tagagaatgc attatatgca ctcagcgctg tggggcattt tactttaggt    1740

tgcgtattgg aagatcaaga gcatcaagtc gctaaagaag aaagggaaac acctactact    1800

gatagtatgc cgccattatt acgacaagct atcgaattat ttgatcacca aggtgcagag    1860

ccagccttct tattcggcct tgaattgatc atatgcggat tagaaaaaca acttaaatgt    1920

gaaagtgggt ccgcgtacag ccgcgcgcgt acgaaaaaca attacgggtc taccatcgag    1980

ggcctgctcg atctcccgga cgacgacgcc cccgaagagg cggggctggc ggctccgcgc    2040

ctgtcctttc tccccgcggg acacacgcgc agactgtcga cggccccccc gaccgatgtc    2100

agcctggggg acgagctcca cttagacggc gaggacgtgg cgatggcgca tgccgacgcg    2160

ctagacgatt tcgatctgga catgttgggg gacggggatt ccccgggtcc gggatttacc    2220

ccccacgact ccgcccccta cggcgctctg gatatggccg acttcgagtt tgagcagatg    2280

tttaccgatg cccttggaat tgacgagtac ggtgggtag                           2319


<210> 23
<211> 772
<212> PRT
<213> Artificial Sequence

<220> 
<223> CaM – TEV-N – AsLOV2 –TEVseq – TetR-VP16(tTA)

<400> 23
Met Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      
Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          
Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              
Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile 
    50                  55                  60                  
Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr Arg 
65                  70                  75                  80  
Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys Asp 
                85                  90                  95      
Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         
Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             
Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 
Met Met Thr Ala Lys Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Leu Glu Met Gly Glu Ser Leu Phe Lys Gly Pro 
                165                 170                 175     
Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile Cys His Leu Thr Asn Glu 
            180                 185                 190         
Ser Asp Gly His Thr Thr Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe 
        195                 200                 205             
Ile Ile Thr Asn Lys His Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu 
    210                 215                 220                 
Val Gln Ser Leu His Gly Val Phe Lys Val Lys Asn Thr Thr Thr Leu 
225                 230                 235                 240 
Gln Gln His Leu Ile Asp Gly Arg Asp Met Ile Ile Ile Arg Met Pro 
                245                 250                 255     
Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu Lys Phe Arg Glu Pro Gln 
            260                 265                 270         
Arg Glu Glu Arg Ile Cys Leu Val Thr Thr Asn Phe Gln Glu Leu Gly 
        275                 280                 285             
Ser Gly Ser Gly Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys 
    290                 295                 300                 
Asn Phe Val Ile Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe 
305                 310                 315                 320 
Ala Ser Asp Ser Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile 
                325                 330                 335     
Leu Gly Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala 
            340                 345                 350         
Thr Val Arg Lys Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr 
        355                 360                 365             
Val Gln Leu Ile Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val 
    370                 375                 380                 
Phe His Leu Gln Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe 
385                 390                 395                 400 
Ile Gly Val Gln Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu 
                405                 410                 415     
Arg Glu Ala Val Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile Ala Glu 
            420                 425                 430         
Asn Leu Tyr Phe Gln Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn 
        435                 440                 445             
Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr 
    450                 455                 460                 
Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp 
465                 470                 475                 480 
His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met 
                485                 490                 495     
Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp 
            500                 505                 510         
Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu 
        515                 520                 525             
Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu 
    530                 535                 540                 
Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln 
545                 550                 555                 560 
Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His 
                565                 570                 575     
Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys 
            580                 585                 590         
Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg 
        595                 600                 605             
Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu 
    610                 615                 620                 
Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys 
625                 630                 635                 640 
Glu Ser Gly Ser Ala Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly 
                645                 650                 655     
Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu 
            660                 665                 670         
Glu Ala Gly Leu Ala Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His 
        675                 680                 685             
Thr Arg Arg Leu Ser Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp 
    690                 695                 700                 
Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala 
705                 710                 715                 720 
Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly 
                725                 730                 735     
Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met 
            740                 745                 750         
Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp 
        755                 760                 765             
Glu Tyr Gly Gly 
    770         

<210> 24
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> TEV-N

<400> 24
Met Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser 
1               5                   10                  15      
Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser 
            20                  25                  30          
Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu 
        35                  40                  45              
Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val 
    50                  55                  60                  
Phe Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly 
65                  70                  75                  80  
Arg Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro 
                85                  90                  95      
Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu 
            100                 105                 110         
Val Thr Thr Asn Phe Gln 
        115             

<210> 25
<211> 99
<212> PRT
<213> Artificial Sequence

<220> 
<223> TEV-C

<400> 25
Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro Ser Ser Asp 
1               5                   10                  15      
Gly Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly 
            20                  25                  30          
Ser Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser 
        35                  40                  45              
Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser Val Pro Lys 
    50                  55                  60                  
Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser 
65                  70                  75                  80  
Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly His Lys Val 
                85                  90                  95      
Phe Met Val 
            

<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> T7 tag

<400> 26
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      

<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Xpress tag

<400> 27
Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               

<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Myc tag

<400> 28
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  

<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> NES (Nuclear Export Sequence)

<400> 29
Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Glu 
1               5                   10          

<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgK leader sequence

<400> 30
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp 
            20      

<210> 31
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A sequence (for bicistronic system)

<400> 31
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      
Pro Gly Pro 
            

<210> 32
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker sequence

<400> 32
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Ser 
1               5                   10                  15      
Gly Gly Ser 
            

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker sequence

<400> 33
Gly Gly Ser Gly Gly Leu Glu Gly 
1               5               

<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker sequence

<400> 34
Gly Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser 
1               5                   10      

<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker sequence

<400> 35
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  

<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker sequence

<400> 36
Gly Ser Gly Ser Gly 
1               5   

<210> 37
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 37
aagctttttt gggcactggt cgtggttgct ggagtcctgt tttgttatgg cttgctagtg     60

acagtggctc tttgtgtt                                                   78


<210> 38
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 38
Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr 
1               5                   10                  15      
Gly Leu Leu Val Thr Val Ala Leu Cys Val 
            20                  25      

<210> 39
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD 8a transmembrane domain

<400> 39
atttacatct gggcaccctt ggccggaatc tgcgtggccc ttctgctgtc cttgatcatc     60

actctcatct gctac                                                      75


<210> 40
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD 8a transmembrane domain

<400> 40
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu 
1               5                   10                  15      
Ser Leu Ile Ile Thr Leu Ile Cys Tyr 
            20                  25  

<210> 41
<211> 267
<212> DNA
<213> Artificial Sequence

<220> 
<223> TM-domain (IgK leader sequence / Myc tag / PDGFR sequence)

<400> 41
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt     60

gacgaacaaa aactcatctc agaagaggat ctgaatgctg tgggccagga cacgcaggag    120

gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc    180

ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca    240

cgtggtggct ctggaggtct cgaggga                                        267


<210> 42
<211> 89
<212> PRT
<213> Artificial Sequence

<220> 
<223> TM-domain (IgK leader sequence / Myc tag / PDGFR sequence)

<400> 42
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
            20                  25                  30          
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        35                  40                  45              
Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    50                  55                  60                  
Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
65                  70                  75                  80  
Arg Gly Gly Ser Gly Gly Leu Glu Gly 
                85                  

<210> 43
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> linking sequence in SEQ ID NO: 1

<400> 43
Ala Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Arg Ser Gly Gly Ser Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr 
            20                  25                  30          
Leu Glu 
        

<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> linking sequence in SEQ ID NO: 3

<400> 44
Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly 
1               5                   10                  15      
Leu Glu 
        

<210> 45
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> linking sequence in SEQ ID NO: 5

<400> 45
Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Gly Ser Gly Gly 
1               5                   10                  15      
Leu Glu Gly 
            

<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> linking sequence in SEQ ID NO: 8

<400> 46
Ala Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Arg 
    

<210> 47
<211> 462
<212> DNA
<213> Artificial Sequence

<220> 
<223> Backbone Sequence B

<400> 47
aagcttgatt taggtgacac tatagaatac aagctacttg ttctttttgc aggatccatg      60

cttcaacttc ctcctcttga acgtcttact ctcgaggcca ccctgcagga gctcggtgga     120

ggcggccgct ccggtggcgg tggctctact aagagcatgt ccagcatggt gagcgatact     180

agctgtacct tcccatcatc tgacggaatc ttctggaagc actggattca gactaaggac     240

ggccagtgtg gcagcccact ggtgagcaca cgagacggat tcatcgtggg gattcacagc     300

gcctccaact ttacaaacac caataactat ttcacctcag tgccaaagaa ctttatggag     360

ctgctgacca accaggaggc ccagcagtgg gtgagcgggt ggcgcctgaa cgccgattcc     420

gtgctgtggg gcgggcacaa ggtgtttatg gtgtgagcta gc                        462


<210> 48
<211> 275
<212> DNA
<213> Artificial Sequence

<220> 
<223> Backbone Sequence C

<400> 48
aagcttgatt taggtgacac tatagaatac aagctacttg ttctttttgc aatgaagacg     60

atcatcgccc tgagctacat cttctgcctg gtattcgccg actacaagga cgatgatgac    120

gccagcatgg atccgaattc ggacgcaccc cacccagcct gggtccccaa gatgagtcct    180

gcaccaccgc cagctcctcc ctggccaagg acacttcatc gcttcaactt cctcctcttg    240

aacgtcttac tctcggtggc tctggaggtc tcgag                               275


<210> 49
<211> 138
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLITz-6: AsLOV2 (1-138 A.A.)

<400> 49
Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile 
1               5                   10                  15      
Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser 
            20                  25                  30          
Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn 
        35                  40                  45              
Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys 
    50                  55                  60                  
Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile 
65                  70                  75                  80  
Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe His Leu Gln 
                85                  90                  95      
Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln 
            100                 105                 110         
Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg Glu Ala Val 
        115                 120                 125             
Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile 
    130                 135             

<210> 50
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLITz-6: AsLOV2 (1-138 A.A.)

<400> 50
gagtttctgg caaccacact ggaacggatc gagaaaaatt tcgtgattac tgatccgaga      60

ctgcctgaca acccaatcat ttttgcgagc gattccttcc tgcagctgac agaatattct     120

cgggaagaga tcctggggcg caattgccgt tttctgcagg gacccgagac agaccgtgcc     180

actgttcgga aaatcagaga tgctattgac aaccagactg aagtgaccgt tcagctgatc     240

aattatacca agagcggcaa gaagttctgg aacgtgttcc acctgcagcc gatgcgcgat     300

tataagggcg acgtccagta cttcattggc gtgcagctgg atggcaccga acgtcttcat     360

ggcgccgctg agcgtgaggc ggtctgcctg atcaaaaaga cagcctttca gatt           414


<210> 51
<211> 139
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLITz-1: AsLOV2 (1-139 A.A.)

<400> 51
Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile 
1               5                   10                  15      
Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser 
            20                  25                  30          
Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn 
        35                  40                  45              
Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys 
    50                  55                  60                  
Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile 
65                  70                  75                  80  
Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe His Leu Gln 
                85                  90                  95      
Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln 
            100                 105                 110         
Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg Glu Ala Val 
        115                 120                 125             
Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile Ala 
    130                 135                 

<210> 52
<211> 417
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLITz-1: AsLOV2 (1-139 A.A.)

<400> 52
gagtttctgg caaccacact ggaacggatc gagaaaaatt tcgtgattac tgatccgaga      60

ctgcctgaca acccaatcat ttttgcgagc gattccttcc tgcagctgac agaatattct     120

cgggaagaga tcctggggcg caattgccgt tttctgcagg gacccgagac agaccgtgcc     180

actgttcgga aaatcagaga tgctattgac aaccagactg aagtgaccgt tcagctgatc     240

aattatacca agagcggcaa gaagttctgg aacgtgttcc acctgcagcc gatgcgcgat     300

tataagggcg acgtccagta cttcattggc gtgcagctgg atggcaccga acgtcttcat     360

ggcgccgctg agcgtgaggc ggtctgcctg atcaaaaaga cagcctttca gattgct        417


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TEV cleavage site

<400> 53
Glu Asn Leu Tyr Phe Gln Gly 
1               5           

<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TEV cleavage site

<400> 54
Glu Ala Leu Tyr Phe Gln Gly 
1               5           

<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> TEV cleavage site

<400> 55
gagaacctgt acttccaggg c                                              21


<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> TEV protease cleavage site EALYFQG

<400> 56
gaggccctgt acttccaggg c                                              21


<210> 57
<211> 1887
<212> DNA
<213> Artificial Sequence

<220> 
<223> CRY2PHR – TEV-C

<400> 57
cttcaacttc ctcctcttga acgtcttact ctcgaggcca ccatgaagat ggacaaaaag      60

actatagttt ggtttagaag agacctaagg attgaggata atcctgcatt agcagcagct     120

gctcacgaag gatctgtttt tcctgtcttc atttggtgtc ctgaagaaga aggacagttt     180

tatcctggaa gagcttcaag atggtggatg aaacaatcac ttgctcactt atctcaatcc     240

ttgaaggctc ttggatctga cctcacttta atcaaaaccc acaacacgat ttcagcgatc     300

ttggattgta tccgcgttac cggtgctaca aaagtcgtct ttaaccacct ctatgatcct     360

gtttcgttag ttcgggacca taccgtaaag gagaagctgg tggaacgtgg gatctctgtg     420

caaagctaca atggagatct attgtatgaa ccgtgggaga tatactgcga aaagggcaaa     480

ccttttacga gtttcaattc ttactggaag aaatgcttag atatgtcgat tgaatccgtt     540

atgcttcctc ctccttggcg gttgatgcca ataactgcag cggctgaagc gatttgggcg     600

tgttcgattg aagaactagg gctggagaat gaggccgaga aaccgagcaa tgcgttgtta     660

actagagctt ggtctccagg atggagcaat gctgataagt tactaaatga gttcatcgag     720

aagcagttga tagattatgc aaagaacagc aagaaagttg ttgggaattc tacttcacta     780

ctttctccgt atctccattt cggggaaata agcgtcagac acgttttcca gtgtgcccgg     840

atgaaacaaa ttatatgggc aagagataag aacagtgaag gagaagaaag tgcagatctt     900

tttcttaggg gaatcggttt aagagagtat tctcggtata tatgtttcaa cttcccgttt     960

actcacgagc aatcgttgtt gagtcatctt cggtttttcc cttgggatgc tgatgttgat    1020

aagttcaagg cctggagaca aggcaggacc ggttatccgt tggtggatgc cggaatgaga    1080

gagctttggg ctaccggatg gatgcataac agaataagag tgattgtttc aagctttgct    1140

gtgaagtttc ttctccttcc atggaaatgg ggaatgaagt atttctggga tacacttttg    1200

gatgctgatt tggaatgtga catccttggc tggcagtata tctctgggag tatccccgat    1260

ggccacgagc ttgatcgctt ggacaatccc gcgttacaag gcgccaaata tgacccagaa    1320

ggtgagtaca taaggcaatg gcttcccgag cttgcgagat tgccaactga atggatccat    1380

catccatggg acgctccttt aaccgtactc aaagcttctg gtgtggaact cggaacaaac    1440

tatgcgaaac ccattgtaga catcgacaca gctcgtgagc tactagctaa agctatttca    1500

agaacccgtg aagcacagat catgatcgga gcagcactgc aggagctcgg tggaggcggc    1560

cgctccggtg gcggtggctc tactaagagc atgtccagca tggtgagcga tactagctgt    1620

accttcccat catctgacgg aatcttctgg aagcactgga ttcagactaa ggacggccag    1680

tgtggcagcc cactggtgag cacacgagac ggattcatcg tggggattca cagcgcctcc    1740

aactttacaa acaccaataa ctatttcacc tcagtgccaa agaactttat ggagctgctg    1800

accaaccagg aggcccagca gtgggtgagc gggtggcgcc tgaacgccga ttccgtgctg    1860

tggggcgggc acaaggtgtt tatggtg                                        1887


<210> 58
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> CRY2PHR – TEV-C

<400> 58
Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Glu Ala Thr Met 
1               5                   10                  15      
Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
            20                  25                  30          
Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
        35                  40                  45              
Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
    50                  55                  60                  
Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
65                  70                  75                  80  
Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
                85                  90                  95      
Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
            100                 105                 110         
Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
        115                 120                 125             
Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
    130                 135                 140                 
Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
145                 150                 155                 160 
Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
                165                 170                 175     
Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
            180                 185                 190         
Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
        195                 200                 205             
Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
    210                 215                 220                 
Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
225                 230                 235                 240 
Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
                245                 250                 255     
Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
            260                 265                 270         
Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
        275                 280                 285             
Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
    290                 295                 300                 
Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
305                 310                 315                 320 
Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
                325                 330                 335     
Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
            340                 345                 350         
Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
        355                 360                 365             
Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
    370                 375                 380                 
Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
385                 390                 395                 400 
Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
                405                 410                 415     
Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
            420                 425                 430         
Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
        435                 440                 445             
Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
    450                 455                 460                 
Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
465                 470                 475                 480 
Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
                485                 490                 495     
Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala 
            500                 505                 510         
Ala Leu Gln Glu Leu Gly Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser 
        515                 520                 525             
Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro 
    530                 535                 540                 
Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly 
545                 550                 555                 560 
Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly 
                565                 570                 575     
Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser 
            580                 585                 590         
Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln 
        595                 600                 605             
Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly 
    610                 615                 620                 
His Lys Val Phe Met Val 
625                 630 

<210> 59
<211> 3093
<212> DNA
<213> Artificial Sequence

<220> 
<223> bArr2 – TEV-C – TdTomato

<400> 59
atgggtgaaa aacccgggac cagggtcttc aagaagtcga gccctaactg caagctcacc      60

gtgtacttgg gcaagcgtga ctttgtggat cacttggaca aagtggatcc tgtcgatggt     120

gtggtgcttg tggatcctga ctacttgaag gaccggaaag tgtttgtgac cctcacctgt     180

gccttccgct atggccgaga agacctggat gtactgggcc tgtctttccg caaagatctg     240

ttcatcgcca cctaccaggc cttccccccc atgcccaacc cacctcggcc ccccacccgc     300

ctacaggacc gactgctgaa gaagttgggc cagcacgccc accccttttt tttcacaata     360

ccccagaatt tgccttgctc cgtcacactg cagccaggac cggaggacac agggaaggcc     420

tgtggagtag actttgagat tcgagccttc tgtgccaaat ctatagaaga aaaaagccac     480

aaaaggaact ccgtgcggct tatcatcaga aaggtacagt ttgctcctga gacacccggc     540

ccccagccat cagctgaaac cacacgccac ttcctcatgt ctgaccggag gtccctgcac     600

ctagaggctt ccctggacaa agagctgtac taccatgggg aacccctcaa tgtcaacgtc     660

cacgtcacca acaattctgc caagaccgtc aagaagatca gagtgtctgt gagacagtat     720

gccgacattt gcctcttcag caccgcgcag tacaagtgtc ctgtggctca gcttgaacaa     780

gatgaccagg tgtctcccag ttccacattc tgcaaggtgt acaccataac cccgctgctc     840

agtgacaacc gagagaagcg tggccttgcc cttgatgggc aactcaagca cgaagacacc     900

aacctggctt ccagcaccat tgtgaaggag ggagccaaca aggaggtgct gggaatccta     960

gtatcctaca gggtcaaggt gaagctggtg gtgtctcgag gcggggatgt ctccgtggag    1020

ctacctttcg tcctaatgca ccccaagccc cacgaccaca tcacccttcc ccgaccccag    1080

tcagcccccc gggaaataga catccctgtg gataccaacc tcattgaatt cgataccaac    1140

tatgccacag acgacgacat cgtgtttgag gactttgcga ggcttcggct gaaggggatg    1200

aaggatgacg actgtgatga ccagttctgc ctgagctcac tcgaaggtgg cggtggctct    1260

ggaggtggtg ggtccggagg aggcggcatc gagatgtcca gcatggtgag cgatactagc    1320

tgtaccttcc catcatctga cggaatcttc tggaagcact ggattcagac taaggacggc    1380

cagtgtggca gcccactggt gagcacacga gacggattca tcgtggggat tcacagcgcc    1440

tccaacttta caaacaccaa taactatttc acctcagtgc caaagaactt tatggagctg    1500

ctgaccaacc aggaggccca gcagtgggtg agcgggtggc gcctgaacgc cgattccgtg    1560

ctgtggggcg ggcacaaggt gtttatggca tgcggaagcg gagctactaa cttcagcctg    1620

ctgaagcagg ctggagacgt ggaggagaac cctggacctg aattcatggt gagcaagggc    1680

gaggaggtca tcaaagagtt catgcgcttc aaggtgcgca tggagggctc catgaacggc    1740

cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc    1800

aagctgaagg tgaccaaggg cggccccctg cccttcgcct gggacatcct gtccccccag    1860

ttcatgtacg gctccaaggc gtacgtgaag caccccgccg acatccccga ttacaagaag    1920

ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggtctg    1980

gtgaccgtga cccaggactc ctccctgcag gacggcacgc tgatctacaa ggtgaagatg    2040

cgcggcacca acttcccccc cgacggcccc gtaatgcaga agaagaccat gggctgggag    2100

gcctccaccg agcgcctgta cccccgcgac ggcgtgctga agggcgagat ccaccaggcc    2160

ctgaagctga aggacggcgg ccgctacctg gtggagttca agaccatcta catggccaag    2220

aagcccgtgc aactgcccgg ctactactac gtggacacca agctggacat cacctcccac    2280

aacgaggact acaccatcgt ggaacagtac gagcgctccg agggccgcca ccacctgttc    2340

ctggggcatg gcaccggcag caccggcagc ggcagttccg gcaccgcctc ctccgaggac    2400

aacaacatgg ccgtcatcaa agagttcatg cgcttcaagg tgcgcatgga gggctccatg    2460

aacggccacg agttcgagat cgagggcgag ggcgagggcc gcccctacga gggcacccag    2520

accgccaagc tgaaggtgac caagggcggc cccctgccct tcgcctggga catcctgtcc    2580

ccccagttca tgtacggctc caaggcgtac gtgaagcacc ccgccgacat ccccgattac    2640

aagaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt cgaggacggc    2700

ggtctggtga ccgtgaccca ggactcctcc ctgcaggacg gcacgctgat ctacaaggtg    2760

aagatgcgcg gcaccaactt cccccccgac ggccccgtaa tgcagaagaa gaccatgggc    2820

tgggaggcct ccaccgagcg cctgtacccc cgcgacggcg tgctgaaggg cgagatccac    2880

caggccctga agctgaagga cggcggccgc tacctggtgg agttcaagac catctacatg    2940

gccaagaagc ccgtgcaact gcccggctac tactacgtgg acaccaagct ggacatcacc    3000

tcccacaacg aggactacac catcgtggaa cagtacgagc gctccgaggg ccgccaccac    3060

ctgttcctgt acggcatgga cgagctgtac aag                                 3093


<210> 60
<211> 1031
<212> PRT
<213> Artificial Sequence

<220> 
<223> bArr2 – TEV-C – TdTomato

<400> 60
Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                85                  90                  95      
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
            100                 105                 110         
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
145                 150                 155                 160 
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
        195                 200                 205             
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
    210                 215                 220                 
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
225                 230                 235                 240 
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                245                 250                 255     
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
            260                 265                 270         
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
        275                 280                 285             
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
    290                 295                 300                 
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
305                 310                 315                 320 
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                325                 330                 335     
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
            340                 345                 350         
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
        355                 360                 365             
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
    370                 375                 380                 
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
385                 390                 395                 400 
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys Leu Ser Ser Leu Glu Gly 
                405                 410                 415     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Glu Met 
            420                 425                 430         
Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro Ser Ser Asp Gly 
        435                 440                 445             
Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly Ser 
    450                 455                 460                 
Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser Ala 
465                 470                 475                 480 
Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser Val Pro Lys Asn 
                485                 490                 495     
Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser Gly 
            500                 505                 510         
Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly His Lys Val Phe 
        515                 520                 525             
Met Ala Cys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    530                 535                 540                 
Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Phe Met Val Ser Lys Gly 
545                 550                 555                 560 
Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys Val Arg Met Glu Gly 
                565                 570                 575     
Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg 
            580                 585                 590         
Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly 
        595                 600                 605             
Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 
    610                 615                 620                 
Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Lys Lys 
625                 630                 635                 640 
Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 
                645                 650                 655     
Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly 
            660                 665                 670         
Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr Asn Phe Pro Pro Asp 
        675                 680                 685             
Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu 
    690                 695                 700                 
Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu Ile His Gln Ala 
705                 710                 715                 720 
Leu Lys Leu Lys Asp Gly Gly Arg Tyr Leu Val Glu Phe Lys Thr Ile 
                725                 730                 735     
Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr Tyr Tyr Val Asp 
            740                 745                 750         
Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu 
        755                 760                 765             
Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu Phe Leu Gly His Gly 
    770                 775                 780                 
Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr Ala Ser Ser Glu Asp 
785                 790                 795                 800 
Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg Phe Lys Val Arg Met 
                805                 810                 815     
Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
            820                 825                 830         
Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
        835                 840                 845             
Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
    850                 855                 860                 
Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr 
865                 870                 875                 880 
Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 
                885                 890                 895     
Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser Ser Leu Gln 
            900                 905                 910         
Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr Asn Phe Pro 
        915                 920                 925             
Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 
    930                 935                 940                 
Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu Ile His 
945                 950                 955                 960 
Gln Ala Leu Lys Leu Lys Asp Gly Gly Arg Tyr Leu Val Glu Phe Lys 
                965                 970                 975     
Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr Tyr Tyr 
            980                 985                 990         
Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile 
        995                 1000                1005            
Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu Phe Leu Tyr 
    1010                1015                1020                
Gly Met Asp Glu Leu Tyr Lys 
1025                1030    

<210> 61
<211> 591
<212> DNA
<213> Artificial Sequence

<220> 
<223> TEV-C-M13

<400> 61
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctctt      60

caacttcctc ctcttgaacg tcttactctc ccatggaccg gtatgtccag catggtgagc     120

gatactagct gtaccttccc atcatctgac ggaatcttct ggaagcactg gattcagact     180

aaggacggcc agtgtggcag cccactggtg agcacacgag acggattcat cgtggggatt     240

cacagcgcct ccaactttac aaacaccaat aactatttca cctcagtgcc aaagaacttt     300

atggagctgc tgaccaacca ggaggcccag cagtgggtga gcgggtggcg cctgaacgcc     360

gattccgtgc tgtggggcgg gcacaaggtg tttatggcat gcggtggcgg tggctctgga     420

ggtggtgggt ccggaggagg cggccgcatg gcaagcatga ctggtggaca gcaaatgggt     480

cgggatctgt acgacgatga cgataaggat ctcgccacca tggtcgactc atcacgtcgt     540

aagtggaata agacaggtca cgcagtcaga gctataggtc ggctgagttc a              591


<210> 62
<211> 197
<212> PRT
<213> Artificial Sequence

<220> 
<223> TEV-C-M13

<400> 62
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      
Pro Gly Pro Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Pro Trp 
            20                  25                  30          
Thr Gly Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro Ser 
        35                  40                  45              
Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly Gln 
    50                  55                  60                  
Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly Ile 
65                  70                  75                  80  
His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser Val 
                85                  90                  95      
Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp 
            100                 105                 110         
Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly His 
        115                 120                 125             
Lys Val Phe Met Ala Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Arg Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
145                 150                 155                 160 
Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Leu Ala Thr Met Val Asp 
                165                 170                 175     
Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly His Ala Val Arg Ala Ile 
            180                 185                 190         
Gly Arg Leu Ser Ser 
        195         

<210> 63
<211> 1587
<212> DNA
<213> Artificial Sequence

<220> 
<223> β-arrestin2-TEV-C

<400> 63
atgggtgaaa aacccgggac cagggtcttc aagaagtcga gccctaactg caagctcacc      60

gtgtacttgg gcaagcgtga ctttgtggat cacttggaca aagtggatcc tgtcgatggt     120

gtggtgcttg tggatcctga ctacttgaag gaccggaaag tgtttgtgac cctcacctgt     180

gccttccgct atggccgaga agacctggat gtactgggcc tgtctttccg caaagatctg     240

ttcatcgcca cctaccaggc cttccccccc atgcccaacc cacctcggcc ccccacccgc     300

ctacaggacc gactgctgaa gaagttgggc cagcacgccc accccttttt tttcacaata     360

ccccagaatt tgccttgctc cgtcacactg cagccaggac cggaggacac agggaaggcc     420

tgtggagtag actttgagat tcgagccttc tgtgccaaat ctatagaaga aaaaagccac     480

aaaaggaact ccgtgcggct tatcatcaga aaggtacagt ttgctcctga gacacccggc     540

ccccagccat cagctgaaac cacacgccac ttcctcatgt ctgaccggag gtccctgcac     600

ctagaggctt ccctggacaa agagctgtac taccatgggg aacccctcaa tgtcaacgtc     660

cacgtcacca acaattctgc caagaccgtc aagaagatca gagtgtctgt gagacagtat     720

gccgacattt gcctcttcag caccgcgcag tacaagtgtc ctgtggctca gcttgaacaa     780

gatgaccagg tgtctcccag ttccacattc tgcaaggtgt acaccataac cccgctgctc     840

agtgacaacc gagagaagcg tggccttgcc cttgatgggc aactcaagca cgaagacacc     900

aacctggctt ccagcaccat tgtgaaggag ggagccaaca aggaggtgct gggaatccta     960

gtatcctaca gggtcaaggt gaagctggtg gtgtctcgag gcggggatgt ctccgtggag    1020

ctacctttcg tcctaatgca ccccaagccc cacgaccaca tcacccttcc ccgaccccag    1080

tcagcccccc gggaaataga catccctgtg gataccaacc tcattgaatt cgataccaac    1140

tatgccacag acgacgacat cgtgtttgag gactttgcga ggcttcggct gaaggggatg    1200

aaggatgacg actgtgatga ccagttctgc ctgagctcac tcgaaggtgg cggtggctct    1260

ggaggtggtg ggtccggagg aggcggcatc gagatgtcca gcatggtgag cgatactagc    1320

tgtaccttcc catcatctga cggaatcttc tggaagcact ggattcagac taaggacggc    1380

cagtgtggca gcccactggt gagcacacga gacggattca tcgtggggat tcacagcgcc    1440

tccaacttta caaacaccaa taactatttc acctcagtgc caaagaactt tatggagctg    1500

ctgaccaacc aggaggccca gcagtgggtg agcgggtggc gcctgaacgc cgattccgtg    1560

ctgtggggcg ggcacaaggt gtttatg                                        1587


<210> 64
<211> 529
<212> PRT
<213> Artificial Sequence

<220> 
<223> β-arrestin2-TEV-C

<400> 64
Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                85                  90                  95      
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
            100                 105                 110         
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
145                 150                 155                 160 
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
        195                 200                 205             
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
    210                 215                 220                 
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
225                 230                 235                 240 
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                245                 250                 255     
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
            260                 265                 270         
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
        275                 280                 285             
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
    290                 295                 300                 
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
305                 310                 315                 320 
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                325                 330                 335     
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
            340                 345                 350         
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
        355                 360                 365             
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
    370                 375                 380                 
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
385                 390                 395                 400 
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys Leu Ser Ser Leu Glu Gly 
                405                 410                 415     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Glu Met 
            420                 425                 430         
Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro Ser Ser Asp Gly 
        435                 440                 445             
Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly Ser 
    450                 455                 460                 
Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser Ala 
465                 470                 475                 480 
Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser Val Pro Lys Asn 
                485                 490                 495     
Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser Gly 
            500                 505                 510         
Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly His Lys Val Phe 
        515                 520                 525             
Met 
    

<210> 65
<211> 3165
<212> DNA
<213> Artificial Sequence

<220> 
<223> bArr2 – TEV-N – TdTomato

<400> 65
atgggtgaaa aacccgggac cagggtcttc aagaagtcga gccctaactg caagctcacc       60

gtgtacttgg gcaagcgtga ctttgtggat cacttggaca aagtggatcc tgtcgatggt      120

gtggtgcttg tggatcctga ctacttgaag gaccggaaag tgtttgtgac cctcacctgt      180

gccttccgct atggccgaga agacctggat gtactgggcc tgtctttccg caaagatctg      240

ttcatcgcca cctaccaggc cttccccccc atgcccaacc cacctcggcc ccccacccgc      300

ctacaggacc gactgctgaa gaagttgggc cagcatgccc accccttttt tttcacaata      360

ccccagaatt tgccttgctc cgtcacactg cagccaggac cggaggacac agggaaggcc      420

tgtggagtag actttgagat tcgagccttc tgtgccaaat ctatagaaga aaaaagccac      480

aaaaggaact ccgtgcggct tatcatcaga aaggtacagt ttgctcctga gacacccggc      540

ccccagccat cagctgaaac cacacgccac ttcctcatgt ctgaccggag gtccctgcac      600

ctagaggctt ccctggacaa agagctgtac taccatgggg aacccctcaa tgtcaacgtc      660

cacgtcacca acaattctgc caagaccgtc aagaagatca gagtgtctgt gagacagtat      720

gccgacattt gcctcttcag caccgcgcag tacaagtgtc ctgtggctca gcttgaacaa      780

gatgaccagg tgtctcccag ttccacattc tgcaaggtgt acaccataac cccgctgctc      840

agtgacaacc gagagaagcg tggccttgcc cttgatgggc aactcaagca cgaagacacc      900

aacctggctt ccagcaccat tgtgaaggag ggagccaaca aggaggtgct gggaatccta      960

gtatcctaca gggtcaaggt gaagctggtg gtgtctcgag gcggggatgt ctccgtggag     1020

ctacctttcg tcctaatgca ccccaagccc cacgaccaca tcacccttcc ccgaccccag     1080

tcagcccccc gggaaataga catccctgtg gataccaacc tcattgaatt cgataccaac     1140

tatgccacag acgacgacat cgtgtttgag gactttgcga ggcttcggct gaaggggatg     1200

aaggatgacg actgtgatga ccagttctgc ctgagctcac tcgaaggtgg cggtggctct     1260

ggaggtggtg ggtccggagg aggcggcatc gagggtatgg gcgagagcct gttcaaggga     1320

cctagggact acaaccctat cagtagcaca atttgtcacc tgaccaacga gagtgatggc     1380

cacacaacaa gcctgtacgg catcgggttc ggacccttta tcatcaccaa caagcacctg     1440

ttcaggcgga ataatggcac tctgctggtg cagagcctgc acggggtgtt caaagtgaag     1500

aacacaacca ctctgcagca gcacctgatc gatgggcggg atatgatcat cattaggatg     1560

cccaaggact tccccccttt tcctcagaaa ctgaagttcc gagagcccca gagagaggag     1620

agaatctgtc tggtgaccac aaactttcag gcatgcggaa gcggagctac taacttcagc     1680

ctgctgaagc aggctggaga cgtggaggag aaccctggac ctgaattcat ggtgagcaag     1740

ggcgaggagg tcatcaaaga gttcatgcgc ttcaaggtgc gcatggaggg ctccatgaac     1800

ggccacgagt tcgagatcga gggcgagggc gagggccgcc cctacgaggg cacccagacc     1860

gccaagctga aggtgaccaa gggcggcccc ctgcccttcg cctgggacat cctgtccccc     1920

cagttcatgt acggctccaa ggcgtacgtg aagcaccccg ccgacatccc cgattacaag     1980

aagctgtcct tccccgaggg cttcaagtgg gagcgcgtga tgaacttcga ggacggcggt     2040

ctggtgaccg tgacccagga ctcctccctg caggacggca cgctgatcta caaggtgaag     2100

atgcgcggca ccaacttccc ccccgacggc cccgtaatgc agaagaagac catgggctgg     2160

gaggcctcca ccgagcgcct gtacccccgc gacggcgtgc tgaagggcga gatccaccag     2220

gccctgaagc tgaaggacgg cggccgctac ctggtggagt tcaagaccat ctacatggcc     2280

aagaagcccg tgcaactgcc cggctactac tacgtggaca ccaagctgga catcacctcc     2340

cacaacgagg actacaccat cgtggaacag tacgagcgct ccgagggccg ccaccacctg     2400

ttcctggggc atggcaccgg cagcaccggc agcggcagtt ccggcaccgc ctcctccgag     2460

gacaacaaca tggccgtcat caaagagttc atgcgcttca aggtgcgcat ggagggctcc     2520

atgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc     2580

cagaccgcca agctgaaggt gaccaagggc ggccccctgc ccttcgcctg ggacatcctg     2640

tccccccagt tcatgtacgg ctccaaggcg tacgtgaagc accccgccga catccccgat     2700

tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac     2760

ggcggtctgg tgaccgtgac ccaggactcc tccctgcagg acggcacgct gatctacaag     2820

gtgaagatgc gcggcaccaa cttccccccc gacggccccg taatgcagaa gaagaccatg     2880

ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa gggcgagatc     2940

caccaggccc tgaagctgaa ggacggcggc cgctacctgg tggagttcaa gaccatctac     3000

atggccaaga agcccgtgca actgcccggc tactactacg tggacaccaa gctggacatc     3060

acctcccaca acgaggacta caccatcgtg gaacagtacg agcgctccga gggccgccac     3120

cacctgttcc tgtacggcat ggacgagctg tacaagtgtg gcggc                     3165


<210> 66
<211> 1055
<212> PRT
<213> Artificial Sequence

<220> 
<223> bArr2 – TEV-N – TdTomato

<400> 66
Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                85                  90                  95      
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
            100                 105                 110         
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
145                 150                 155                 160 
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
        195                 200                 205             
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
    210                 215                 220                 
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
225                 230                 235                 240 
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                245                 250                 255     
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
            260                 265                 270         
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
        275                 280                 285             
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
    290                 295                 300                 
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
305                 310                 315                 320 
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                325                 330                 335     
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
            340                 345                 350         
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
        355                 360                 365             
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
    370                 375                 380                 
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
385                 390                 395                 400 
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys Leu Ser Ser Leu Glu Gly 
                405                 410                 415     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Glu Gly 
            420                 425                 430         
Met Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser 
        435                 440                 445             
Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser 
    450                 455                 460                 
Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu 
465                 470                 475                 480 
Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val 
                485                 490                 495     
Phe Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly 
            500                 505                 510         
Arg Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro 
        515                 520                 525             
Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu 
    530                 535                 540                 
Val Thr Thr Asn Phe Gln Ala Cys Gly Ser Gly Ala Thr Asn Phe Ser 
545                 550                 555                 560 
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Phe 
                565                 570                 575     
Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
            580                 585                 590         
Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
        595                 600                 605             
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
    610                 615                 620                 
Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
625                 630                 635                 640 
Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
                645                 650                 655     
Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
            660                 665                 670         
Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
        675                 680                 685             
Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
    690                 695                 700                 
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
705                 710                 715                 720 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
                725                 730                 735     
Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly Arg Tyr Leu Val 
            740                 745                 750         
Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
        755                 760                 765             
Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
    770                 775                 780                 
Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
785                 790                 795                 800 
Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
                805                 810                 815     
Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
            820                 825                 830         
Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
        835                 840                 845             
Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
    850                 855                 860                 
Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
865                 870                 875                 880 
Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
                885                 890                 895     
Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
            900                 905                 910         
Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
        915                 920                 925             
Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
    930                 935                 940                 
Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
945                 950                 955                 960 
Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
                965                 970                 975     
Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly Arg Tyr 
            980                 985                 990         
Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
        995                 1000                1005            
Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
    1010                1015                1020                
Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
1025                1030                1035                1040
His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys Cys Gly Gly 
                1045                1050                1055

<210> 67
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> β-arrestin2-TEV-N

<400> 67
atgggtgaaa aacccgggac cagggtcttc aagaagtcga gccctaactg caagctcacc      60

gtgtacttgg gcaagcgtga ctttgtggat cacttggaca aagtggatcc tgtcgatggt     120

gtggtgcttg tggatcctga ctacttgaag gaccggaaag tgtttgtgac cctcacctgt     180

gccttccgct atggccgaga agacctggat gtactgggcc tgtctttccg caaagatctg     240

ttcatcgcca cctaccaggc cttccccccc atgcccaacc cacctcggcc ccccacccgc     300

ctacaggacc gactgctgaa gaagttgggc cagcatgccc accccttttt tttcacaata     360

ccccagaatt tgccttgctc cgtcacactg cagccaggac cggaggacac agggaaggcc     420

tgtggagtag actttgagat tcgagccttc tgtgccaaat ctatagaaga aaaaagccac     480

aaaaggaact ccgtgcggct tatcatcaga aaggtacagt ttgctcctga gacacccggc     540

ccccagccat cagctgaaac cacacgccac ttcctcatgt ctgaccggag gtccctgcac     600

ctagaggctt ccctggacaa agagctgtac taccatgggg aacccctcaa tgtcaacgtc     660

cacgtcacca acaattctgc caagaccgtc aagaagatca gagtgtctgt gagacagtat     720

gccgacattt gcctcttcag caccgcgcag tacaagtgtc ctgtggctca gcttgaacaa     780

gatgaccagg tgtctcccag ttccacattc tgcaaggtgt acaccataac cccgctgctc     840

agtgacaacc gagagaagcg tggccttgcc cttgatgggc aactcaagca cgaagacacc     900

aacctggctt ccagcaccat tgtgaaggag ggagccaaca aggaggtgct gggaatccta     960

gtatcctaca gggtcaaggt gaagctggtg gtgtctcgag gcggggatgt ctccgtggag    1020

ctacctttcg tcctaatgca ccccaagccc cacgaccaca tcacccttcc ccgaccccag    1080

tcagcccccc gggaaataga catccctgtg gataccaacc tcattgaatt cgataccaac    1140

tatgccacag acgacgacat cgtgtttgag gactttgcga ggcttcggct gaaggggatg    1200

aaggatgacg actgtgatga ccagttctgc ctgagctcac tcgaaggtgg cggtggctct    1260

ggaggtggtg ggtccggagg aggcggcatc gagggtatgg gcgagagcct gttcaaggga    1320

cctagggact acaaccctat cagtagcaca atttgtcacc tgaccaacga gagtgatggc    1380

cacacaacaa gcctgtacgg catcgggttc ggacccttta tcatcaccaa caagcacctg    1440

ttcaggcgga ataatggcac tctgctggtg cagagcctgc acggggtgtt caaagtgaag    1500

aacacaacca ctctgcagca gcacctgatc gatgggcggg atatgatcat cattaggatg    1560

cccaaggact tccccccttt tcctcagaaa ctgaagttcc gagagcccca gagagaggag    1620

agaatctgtc tggtgaccac aaactttcag                                     1650


<210> 68
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> β-arrestin2-TEV-N

<400> 68
Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                85                  90                  95      
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
            100                 105                 110         
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
145                 150                 155                 160 
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
        195                 200                 205             
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
    210                 215                 220                 
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
225                 230                 235                 240 
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                245                 250                 255     
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
            260                 265                 270         
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
        275                 280                 285             
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
    290                 295                 300                 
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
305                 310                 315                 320 
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                325                 330                 335     
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
            340                 345                 350         
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
        355                 360                 365             
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
    370                 375                 380                 
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
385                 390                 395                 400 
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys Leu Ser Ser Leu Glu Gly 
                405                 410                 415     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Glu Gly 
            420                 425                 430         
Met Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser 
        435                 440                 445             
Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser 
    450                 455                 460                 
Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu 
465                 470                 475                 480 
Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val 
                485                 490                 495     
Phe Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly 
            500                 505                 510         
Arg Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro 
        515                 520                 525             
Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu 
    530                 535                 540                 
Val Thr Thr Asn Phe Gln 
545                 550 

<210> 69
<211> 1887
<212> DNA
<213> Artificial Sequence

<220> 
<223> CRY2PHR – TEV-C

<400> 69
cttcaacttc ctcctcttga acgtcttact ctcgaggcca ccatgaagat ggacaaaaag      60

actatagttt ggtttagaag agacctaagg attgaggata atcctgcatt agcagcagct     120

gctcacgaag gatctgtttt tcctgtcttc atttggtgtc ctgaagaaga aggacagttt     180

tatcctggaa gagcttcaag atggtggatg aaacaatcac ttgctcactt atctcaatcc     240

ttgaaggctc ttggatctga cctcacttta atcaaaaccc acaacacgat ttcagcgatc     300

ttggattgta tccgcgttac cggtgctaca aaagtcgtct ttaaccacct ctatgatcct     360

gtttcgttag ttcgggacca taccgtaaag gagaagctgg tggaacgtgg gatctctgtg     420

caaagctaca atggagatct attgtatgaa ccgtgggaga tatactgcga aaagggcaaa     480

ccttttacga gtttcaattc ttactggaag aaatgcttag atatgtcgat tgaatccgtt     540

atgcttcctc ctccttggcg gttgatgcca ataactgcag cggctgaagc gatttgggcg     600

tgttcgattg aagaactagg gctggagaat gaggccgaga aaccgagcaa tgcgttgtta     660

actagagctt ggtctccagg atggagcaat gctgataagt tactaaatga gttcatcgag     720

aagcagttga tagattatgc aaagaacagc aagaaagttg ttgggaattc tacttcacta     780

ctttctccgt atctccattt cggggaaata agcgtcagac acgttttcca gtgtgcccgg     840

atgaaacaaa ttatatgggc aagagataag aacagtgaag gagaagaaag tgcagatctt     900

tttcttaggg gaatcggttt aagagagtat tctcggtata tatgtttcaa cttcccgttt     960

actcacgagc aatcgttgtt gagtcatctt cggtttttcc cttgggatgc tgatgttgat    1020

aagttcaagg cctggagaca aggcaggacc ggttatccgt tggtggatgc cggaatgaga    1080

gagctttggg ctaccggatg gatgcataac agaataagag tgattgtttc aagctttgct    1140

gtgaagtttc ttctccttcc atggaaatgg ggaatgaagt atttctggga tacacttttg    1200

gatgctgatt tggaatgtga catccttggc tggcagtata tctctgggag tatccccgat    1260

ggccacgagc ttgatcgctt ggacaatccc gcgttacaag gcgccaaata tgacccagaa    1320

ggtgagtaca taaggcaatg gcttcccgag cttgcgagat tgccaactga atggatccat    1380

catccatggg acgctccttt aaccgtactc aaagcttctg gtgtggaact cggaacaaac    1440

tatgcgaaac ccattgtaga catcgacaca gctcgtgagc tactagctaa agctatttca    1500

agaacccgtg aagcacagat catgatcgga gcagcactgc aggagctcgg tggaggcggc    1560

cgctccggtg gcggtggctc tactaagagc atgtccagca tggtgagcga tactagctgt    1620

accttcccat catctgacgg aatcttctgg aagcactgga ttcagactaa ggacggccag    1680

tgtggcagcc cactggtgag cacacgagac ggattcatcg tggggattca cagcgcctcc    1740

aactttacaa acaccaataa ctatttcacc tcagtgccaa agaactttat ggagctgctg    1800

accaaccagg aggcccagca gtgggtgagc gggtggcgcc tgaacgccga ttccgtgctg    1860

tggggcgggc acaaggtgtt tatggtg                                        1887


<210> 70
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> CRY2PHR – TEV-C

<400> 70
Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Glu Ala Thr Met 
1               5                   10                  15      
Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
            20                  25                  30          
Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
        35                  40                  45              
Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
    50                  55                  60                  
Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
65                  70                  75                  80  
Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
                85                  90                  95      
Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
            100                 105                 110         
Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
        115                 120                 125             
Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
    130                 135                 140                 
Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
145                 150                 155                 160 
Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
                165                 170                 175     
Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
            180                 185                 190         
Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
        195                 200                 205             
Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
    210                 215                 220                 
Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
225                 230                 235                 240 
Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
                245                 250                 255     
Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
            260                 265                 270         
Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
        275                 280                 285             
Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
    290                 295                 300                 
Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
305                 310                 315                 320 
Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
                325                 330                 335     
Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
            340                 345                 350         
Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
        355                 360                 365             
Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
    370                 375                 380                 
Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
385                 390                 395                 400 
Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
                405                 410                 415     
Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
            420                 425                 430         
Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
        435                 440                 445             
Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
    450                 455                 460                 
Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
465                 470                 475                 480 
Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
                485                 490                 495     
Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala 
            500                 505                 510         
Ala Leu Gln Glu Leu Gly Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser 
        515                 520                 525             
Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro 
    530                 535                 540                 
Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly 
545                 550                 555                 560 
Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly 
                565                 570                 575     
Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser 
            580                 585                 590         
Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln 
        595                 600                 605             
Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly 
    610                 615                 620                 
His Lys Val Phe Met Val 
625                 630 

<210> 71
<211> 1332
<212> DNA
<213> Artificial Sequence

<220> 
<223> DRD2 (Dopamine receptor D2)

<400> 71
atggatccac tgaacctgtc ctggtacgat gacgatctgg agaggcagaa ctggagccgg      60

cccttcaatg ggtcagaagg gaaggcagac aggccccact acaactacta tgccatgctg     120

ctcaccctcc tcatctttat catcgtcttt ggcaatgtgc tggtgtgcat ggctgtatcc     180

cgagagaagg ctttgcagac caccaccaac tacttgatag tcagccttgc tgtggctgat     240

cttctggtgg ccacactggt aatgccgtgg gttgtctacc tggaggtggt gggtgagtgg     300

aaattcagca ggattcactg tgacatcttt gtcactctgg atgtcatgat gtgcacagca     360

agcatcctga acctgtgtgc catcagcatt gacaggtaca cagctgtggc aatgcccatg     420

ctgtataaca cacgctacag ctccaagcgc cgagttactg tcatgattgc cattgtctgg     480

gtcctgtcct tcaccatctc ctgcccactg ctcttcggac tcaacaatac agaccagaat     540

gagtgtatca ttgccaaccc tgcctttgtg gtctactcct ccattgtctc attctacgtg     600

cccttcatcg tcactctgct ggtctatatc aaaatctaca tcgtcctccg gaagcgccgg     660

aagcgggtca acaccaagcg cagcagtcga gctttcagag ccaacctgaa gacaccactc     720

aagggcaact gtacccaccc tgaggacatg aaactctgca ccgttatcat gaagtctaat     780

gggagtttcc cagtgaacag gcggagaatg gatgctgccc gccgagctca ggagctggaa     840

atggagatgc tgtcaagcac cagtccccca gagaggaccc ggtatagccc catccctccc     900

agtcaccacc agctcactct ccctgatcca tcccaccacg gcctacatag caaccctgac     960

agtcctgcca aaccagagaa gaatgggcac gccaagattg tcaatcccag gattgccaag    1020

ttctttgaga tccagaccat gcccaatggc aaaacccgga cctcccttaa gacgatgagc    1080

cgcagaaagc tctcccagca gaaggagaag aaagccactc agatgcttgc cattgttctc    1140

ggtgtgttca tcatctgctg gctgcccttc ttcatcacgc acatcctgaa tatacactgt    1200

gattgcaaca tcccaccagt cctctacagc gccttcacat ggctgggcta tgtcaacagt    1260

gccgtcaacc ccatcatcta caccaccttc aacatcgagt tccgcaaggc cttcatgaag    1320

atcttgcact gc                                                        1332


<210> 72
<211> 444
<212> PRT
<213> Artificial Sequence

<220> 
<223> DRD2 (Dopamine receptor D2)

<400> 72
Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      
Asn Trp Ser Arg Pro Phe Asn Gly Ser Glu Gly Lys Ala Asp Arg Pro 
            20                  25                  30          
His Tyr Asn Tyr Tyr Ala Met Leu Leu Thr Leu Leu Ile Phe Ile Ile 
        35                  40                  45              
Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  
Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  
Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      
Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         
Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             
Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 
Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ala Ile Val Trp 
145                 150                 155                 160 
Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     
Thr Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         
Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             
Tyr Ile Lys Ile Tyr Ile Val Leu Arg Lys Arg Arg Lys Arg Val Asn 
    210                 215                 220                 
Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala Asn Leu Lys Thr Pro Leu 
225                 230                 235                 240 
Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     
Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Met Asp Ala 
            260                 265                 270         
Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             
Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 
Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Asn Pro Asp 
305                 310                 315                 320 
Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Ile Val Asn Pro 
                325                 330                 335     
Arg Ile Ala Lys Phe Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr 
            340                 345                 350         
Arg Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys 
        355                 360                 365             
Glu Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile 
    370                 375                 380                 
Ile Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys 
385                 390                 395                 400 
Asp Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly 
                405                 410                 415     
Tyr Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile 
            420                 425                 430         
Glu Phe Arg Lys Ala Phe Met Lys Ile Leu His Cys 
        435                 440                 

<210> 73
<211> 1431
<212> DNA
<213> Artificial Sequence

<220> 
<223> TdTomato

<400> 73
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag      60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac     180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc     240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc     360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag     420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc     480

gagatccacc aggccctgaa gctgaaggac ggcggccgct acctggtgga gttcaagacc     540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg     600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc     660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ttccggcacc     720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc     780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc     840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc     900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc     960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg    1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg    1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag    1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg    1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccgctacct ggtggagttc    1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc    1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc    1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaagta g             1431


<210> 74
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> TdTomato

<400> 74
Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         
Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly Arg Tyr Leu Val 
                165                 170                 175     
Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         
Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 
Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 
Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     
Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         
Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             
Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 
Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 
Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     
Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         
Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             
Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 
Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 
Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly Arg Tyr 
                405                 410                 415     
Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         
Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             
Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 
His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475     

<210> 75
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer XhoI-CIBN-FW

<400> 75
attctcgagg gtggaatgaa tggagctata ggaggtg                              37


<210> 76
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer CIBN-SphI-RV

<400> 76
tttgcatgca tgaatataat ccgttttctc                                     30


<210> 77
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer SacI-AsLOV2 FW

<400> 77
aaagagctcg gtagtggtag tggggagttt ctggc                                35


<210> 78
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-1-TEV-XbaI-RV

<400> 78
ttttctagag ccctggaagt acaggttctc agcaatctga aaggctgtct ttttgatcag     60

gc                                                                    62


<210> 79
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-2-TEV-XbaI-RV

<400> 79
ttttctagag ccctggaagt acaggttctc aaaggctgtc tttttgatca ggcagaccgc     60


<210> 80
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-3-TEV-XbaI-RV

<400> 80
atctagagcc ctggaagtac aaattttcgt cgttcgctgc                           40


<210> 81
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer XbaI-tTA-FW

<400> 81
atgtctagat tagataaaag taaagtgatt aacagc                               36


<210> 82
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer tTA-NheI-RV

<400> 82
tttgctagcc tacccaccgt actcgtcaat tccaag                               36


<210> 83
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-4-FW

<400> 83
cctttcagat tgctgaggct gagaacctgt acttccag                             38


<210> 84
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-4-RV

<400> 84
caggttctca gcctcagcaa tctgaaaggc tgtctttttg                           40


<210> 85
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-5-FW

<400> 85
cagattgctg aggccctgta cttccagggc tctagattag                           40


<210> 86
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-5-RV

<400> 86
gaagtacagg gcctcagcaa tctgaaaggc tgtctttttg                           40


<210> 87
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-6-FW

<400> 87
gcctttcaga ttgagaacct gtacttccag ggctctag                             38


<210> 88
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-6-RV

<400> 88
caggttctca atctgaaagg ctgtcttttt gatcaggc                             38


<210> 89
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer XhoI-CRY2PHR-FW

<400> 89
aaactcgagg ccaccatgaa gatggacaaa aagac                                35


<210> 90
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer CRY2PHR-PstI-RV

<400> 90
tttgctagct gctgctccga tcatgatctg                                     30


<210> 91
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer SphI-AsLOV2-FW

<400> 91
aaagcatgcg gtagtggtag tggggag                                        27


<210> 92
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer tTA-NheI-RV

<400> 92
tttgctagcc tacccaccgt actcgtcaat tccaag                               36


<210> 93
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BamHI-DRD2-FW

<400> 93
tttaagctta tggatccact gaacctgtcc tgg                                  33


<210> 94
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer DRD2-EcoRI-RV

<400> 94
tttgaattcg cagtgcaaga tcttcatgaa ggcc                                 34


<210> 95
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer EcoRI-TdTomato-FW

<400> 95
cctgaattca tggtgagcaa gggcgag                                        27


<210> 96
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer TdTomato-XbaI-RV

<400> 96
ctatctagac tacttgtaca gctcgtcc                                       28


<210> 97
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer SacI-LK-TEV-N-FW

<400> 97
aaagagctca ctcgaaggtg gcggtggctc tggaggtgg                            39


<210> 98
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer TEV-N-SphI RV

<400> 98
tttgcatgcc tgaaagtttg tggtcaccag ac                                   32


<210> 99
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer Hind3-β- Arr2-FW

<400> 99
tttaagctta tgggtgaaaa acccgggacc aggg                                 34


<210> 100
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer β-Arr2-SacI-RV

<400> 100
aaagagctca ggcagaactg gtcatcacag tcgtc                                35


<210> 101
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer XhoI-TEV-N FW

<400> 101
aaactcgagg gtatgggcga gagcctgttc aaggg                                35


<210> 102
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer BLITz-1-TEV-XbaI-RV

<400> 102
ttttctagag ccctggaagt acaggttctc agcaatctga aaggctgtct ttttgatcag     60

gc                                                                    62


<210> 103
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer SacI-TEV-C-FW

<400> 103
aaagagctca ggtggcggtg gctctggagg tggtggg                              37


<210> 104
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer TEV-C-SphI-RV

<400> 104
tttgcatgca ccccggcgcc tcctgcgatt catc                                 34


<210> 105
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer EcoRI-EGFP-FW

<400> 105
cctgaattca tggtgagcaa gggcgagg                                       28


<210> 106
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer EGFP-NheI-RV

<400> 106
taagctagcc tacttgtaca gctcgtccat gccg                                 34


<210> 107
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> TEV-N

<400> 107
atgggcgaga gcctgttcaa gggacctagg gactacaacc ctatcagtag cacaatttgt      60

cacctgacca acgagagtga tggccacaca acaagcctgt acggcatcgg gttcggaccc     120

tttatcatca ccaacaagca cctgttcagg cggaataatg gcactctgct ggtgcagagc     180

ctgcacgggg tgttcaaagt gaagaacaca accactctgc agcagcacct gatcgatggg     240

cgggatatga tcatcattag gatgcccaag gacttccccc cttttcctca gaaactgaag     300

ttccgagagc cccagagaga ggagagaatc tgtctggtga ccacaaactt tcag           354


<210> 108
<211> 294
<212> DNA
<213> Artificial Sequence

<220> 
<223> TEV-C

<400> 108
atgtccagca tggtgagcga tactagctgt accttcccat catctgacgg aatcttctgg     60

aagcactgga ttcagactaa ggacggccag tgtggcagcc cactggtgag cacacgagac    120

ggattcatcg tggggattca cagcgcctcc aactttacaa acaccaataa ctatttcacc    180

tcagtgccaa agaactttat ggagctgctg accaaccagg aggcccagca gtgggtgagc    240

gggtggcgcc tgaacgccga ttccgtgctg tggggcgggc acaaggtgtt tatg          294


