﻿               SEQUENCE LISTING

<110> EyeServ GmbH, Tübingen, Germany

<120> Gene Therapy for the Treatment of a Retinal Degeneration Disease

<130> 1884P101WO

<160> 8

<170> BiSSAP 1.3

<210> 1
<211> 848
<212> DNA
<213> Artificial Sequence

<220> 
<223> hRHO promoter nucleotide sequence

<400> 1
gctagcagat cttccccacc tagccacctg gcaaactgct ccttctctca aaggcccaaa      60

catggcctcc cagactgcaa cccccaggca gtcaggccct gtctccacaa cctcacagcc     120

accctggacg gaatctgctt cttcccacat ttgagtcctc ctcagcccct gagctcctct     180

gggcagggct gtttctttcc atctttgtat tcccaggggc ctgcaaataa atgtttaatg     240

aacgaacaag agagtgaatt ccaattccat gcaacaagga ttgggctcct gggccctagg     300

ctatgtgtct ggcaccagaa acggaagctg caggttgcag cccctgccct catggagctc     360

ctcctgtcag aggagtgtgg ggactggatg actccagagg taacttgtgg gggaacgaac     420

aggtaagggg ctgtgtgacg agatgagaga ctgggagaat aaaccagaaa gtctctagct     480

gtccagagga catagcacag aggcccatgg tccctatttc aaacccaggc caccagactg     540

agctgggacc ttgggacaga caagtcatgc agaagttagg ggaccttctc ctcccttttc     600

ctggatcctg agtacctctc ctccctgacc tcaggcttcc tcctagtgtc accttggccc     660

ctcttagaag ccaattaggc cctcagtttc tgcagcgggg attaatatga ttatgaacac     720

ccccaatctc ccagatgctg attcagccag gagcttagga gggggaggtc actttataag     780

ggtctggggg ggtcagaacc cagagtcatc cgcctgaatt ctgcagatat ccatcacact     840

ggcggccg                                                              848


<210> 2
<211> 2581
<212> DNA
<213> Artificial Sequence

<220> 
<223> hPDE6A nucleotide sequence

<400> 2
atgggcgagg tgacagcaga ggaggtggag aagttcctgg actcgaatat tggctttgcc      60

aaacagtact acaacctcca ctaccgggcc aagctcatct ccgacctcct tggggccaag     120

gaggctgccg tggacttcag caactaccac tccccgagca gcatggagga gagcgaaatc     180

atctttgatc tcctgcggga ctttcaggag aatttacaga cagagaaatg catcttcaat     240

gtcatgaaga agctgtgctt cctcctgcag gcagaccgca tgagcctgtt catgtaccgg     300

acccgcaatg gcatcgcaga gctggccacc aggcttttca atgtccacaa ggatgctgtc     360

ctcgaggact gcctggtgat gcccgaccaa gagatcgtct tccctttgga catgggcatc     420

gtgggccatg tcgcacactc taagaaaatt gctaacgtcc ccaacacaga ggaggatgag     480

catttctgtg actttgtgga catcctcaca gagtacaaga ccaagaacat cttggcttcc     540

cccataatga atgggaagga tgtggtggcc ataatcatgg ctgtgaataa agtggatgga     600

tcccacttca ccaagagaga tgaagagatt cttctcaagt acctcaattt tgcaaatcta     660

atcatgaagg tgtaccacct gagttacctg cacaactgtg aaactcgacg tggccagata     720

ctgctgtggt ctgggagcaa agtctttgaa gaacttacgg acatcgaacg acagttccac     780

aaagccctgt acacagtccg tgctttcctc aactgtgaca gatactctgt gggtctctta     840

gacatgacca agcagaagga attttttgat gtgtggccgg ttctgatggg tgaagttcca     900

ccttactctg gtcccaggac tccggatgga agagaaatta acttttacaa ggtcattgac     960

tacatcctgc atggcaaaga ggacatcaaa gtcatcccga atccacctcc tgaccattgg    1020

gctttagtaa gcggtctccc agcttatgtt gcccagaatg gcctgatttg caacatcatg    1080

aatgcgcctg cggaggactt ttttgcattt cagaaagaac ctctggatga gtctggatgg    1140

atgattaaaa atgtgctttc aatgccgatt gtgaacaaga aggaagaaat tgttggagtg    1200

gccacatttt acaatcgtaa agatgggaag ccctttgatg aaatggatga gacgctcatg    1260

gagtctttga ctcaatttct gggctggtct gtcttaaatc ctgacaccta tgagtcaatg    1320

aataaacttg aaaataggaa ggatattttc caggacatag taaaatatca tgtgaagtgt    1380

gacaatgaag aaattcagaa aatcttgaaa accagagagg tgtatgggaa ggagccatgg    1440

gagtgtgagg aagaggagct ggctgagatc ctgcaagcgg agctgccaga tgcagataaa    1500

tacgaaatta ataaatttca cttcagtgac ttacccctaa cagaactgga gctggtaaaa    1560

tgtggaatac agatgtatta tgagctcaaa gtggtggata aatttcacat tccacaagag    1620

gccctggtgc ggttcatgta ctccctgagt aagggctacc gcaagatcac ctaccacaac    1680

tggcggcacg gcttcaacgt ggggcagacc atgttctccc tgctggtgac gggaaagctg    1740

aagcgctact tcacggacct agaggccttg gccatggtca ctgctgcttt ctgccatgac    1800

attgaccaca gaggcaccaa taacctctac cagatgaaat cccagaaccc actggccaag    1860

ctccatgggt cctctatctt ggaaagacac cacttggagt ttggcaaaac actgctcaga    1920

gacgagagcc tgaatatctt tcaaaacctc aatcgtcgac agcatgagca tgccatccac    1980

atgatggaca ttgcaatcat tgccacagac ctcgccctgt atttcaagaa gaggacgatg    2040

ttccaaaaga tcgtggatca gtctaagaca tatgagagtg aacaggagtg gacacagtac    2100

atgatgctgg agcagacacg gaaggaaatc gttatggcca tgatgatgac cgcctgtgat    2160

ctctcagcca tcaccaaacc ctgggaggtg cagagccagg tagctctgct ggtggctgct    2220

gaattctggg aacaaggtga cctggagcgc acggtgctgc aacagaatcc cattcccatg    2280

atggacagaa acaaagcaga tgaactccct aagcttcaag tcggcttcat tgactttgtt    2340

tgcaccttcg tctacaagga attctcccgt ttccacgagg agatcacccc aatgttggac    2400

gggatcacca acaatcgcaa ggagtggaag gcgcttgctg atgagtacga tgccaagatg    2460

aaggtgcagg aggagaagaa gcagaaacag cagtcggcca agtcagcagc cgcaggaaat    2520

cagccggggg gaaaccccag cccagggggt gcaactacat ccaagtcctg ctgcatccag    2580

t                                                                    2581


<210> 3
<211> 860
<212> PRT
<213> Artificial Sequence

<220> 
<223> hPDE6A amino acid sequence

<400> 3
Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      
Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          
Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              
Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  
Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  
Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      
Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         
Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             
Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 
Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 
His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     
Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         
Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             
Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 
Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 
Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     
Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         
Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             
Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 
Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 
Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     
Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         
Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             
Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 
Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 
Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     
Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         
Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             
Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 
Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 
Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     
Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         
Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             
Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 
Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 
Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     
Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         
Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             
Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 
Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 
Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     
His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         
Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             
Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 
Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 
Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     
Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         
Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             
Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 
Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 
Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     
Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         
Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             
Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 

<210> 4
<211> 543
<212> DNA
<213> Artificial Sequence

<220> 
<223> WPREm nucleotide sequence

<400> 4
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct      60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt     120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg     180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact     240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct     300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc agggctgctc     420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc     480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt     540

cga                                                                   543


<210> 5
<211> 208
<212> DNA
<213> Artificial Sequence

<220> 
<223> BGH pA nucleotide sequence

<400> 5
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc    120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt    180

gggaagacaa tagcaggcat gctgggga                                       208


<210> 6
<211> 130
<212> DNA
<213> Artificial Sequence

<220> 
<223> L-ITR nucleotide sequence

<400> 6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt     60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact    120

aggggttcct                                                           130


<210> 7
<211> 130
<212> DNA
<213> Artificial Sequence

<220> 
<223> R-ITR nucleotide sequence

<400> 7
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag                                                           130


<210> 8
<211> 5591
<212> DNA
<213> Artificial Sequence

<220> 
<223> pGL2.KanR vector backbone nucleotide sequence

<400> 8
tgggcctcag tgagcgagcg agcgcgcagc tgcattaatg aatcggccaa cgcgcgggga       60

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg      120

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag      180

aatcagggga taacgcagga aagaacatgt cgcgttgctg gcgtttttcc ataggctccg      240

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg      300

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac      360

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca      420

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt      480

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc      540

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag      600

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac      660

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt      720

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa      780

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg      840

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga ctgtggaatg      900

tgtgtcagtt aggcgacata ggtgatctat gtagaagcct agtggaacag gttagtttga      960

gtagctttag aatgtaaatt ctgggatcat agtgtagtaa tctctaatta acggtgacgg     1020

tttgtaagac aggtcttcgc aaaatcaagc ggcaggtgat ttcaacagat tcttgctgat     1080

ggtttaggcg tacaatgccc tgaagaataa gtaagagaat agcactcctc gtcgcctaga     1140

attacctacc ggcgtccacc ataccttcga ttatcgcgcc cactctccca ttagtcggca     1200

caggtggatg tgttgcgata gcccgctaag atattctaag gcgtaacgca gatgaatatt     1260

ctacagagtt gccataggcg ttgaacgctt cacggacgat aggaatgttg cgtatagagc     1320

gtgagtcatc gaagtggtgt atacactcgt acttaacatc tagcccggct ctatcagtac     1380

accagtgcct tgaatgacat actcatcatt aaactttctc aacagtcaaa cgaccaagtg     1440

catttccaag gagtgcgaag gagattcatt ctctcgccag cactgtaata ggcactaaaa     1500

gagtgaagat aagctagagt gccgtgctaa gacggtgtcg gaacaaagcg gtcttacggt     1560

cagtcgtatt tcctgtcgag tcccgtccag ttgagcgtat cactcccagt gtactagcaa     1620

gccgagaagg ctgtgcttgg agtcaatcgg atgtaggatg gtctccagac accgggccac     1680

cactcttcac gcctagaagc atagaacgtc gagcagacat caaagtctta gtaccggacg     1740

tgccgtttca ctgcgaatat tacctgaagc tgtaccgtta ttgcggagca aagtgacagt     1800

gctgctctta tcatatttgt attgacgaca gccgccttcg cggtttcctc agactctaga     1860

tcgaatacag gcttattgta ggcagaggca cgcccttgtt agtggctgcg gcaatatctt     1920

ccgatcccct tgtctaacca tgaatcaatt ctctcatttg aagaccctaa tatgtcatca     1980

ttagtgtttc aaatgccacc aaataccgcc tagaaatgtc tatgatgtgt gtccactaga     2040

agttgattca caaacgactg ctagaatcgc gtgatagggc atcttgaagt ttacattgtt     2100

gtatcgcaag gtactccgat cttaatggat gcgaagtggt acggatgcaa tcaagcgcgt     2160

gagagcggta cattagagcg ttcacctacg ctacgctaac gggcgattct gataagaatg     2220

cacattgcgt cgattcataa gatgtctcga ccgcatgcgc aacttgtgaa gtgtctacta     2280

tccctaagcg catatctcgc acagtaaccg aatatgtcgg catctgatgt taccgttgag     2340

ttagtgttca gctcacggaa cttattgtat gagtagagat ttgtaagagc tgttagttag     2400

ctcgctcagc taatagttgc ccacacaacg tcaaattaga gaacggtcgt aacattatcg     2460

gtggttctct aactactatc agtacccacg actcgactct gccgcagcta ggtatcgcct     2520

gaaagccagt cagcgttaag gagtgctctg accaggacaa caggcgtagt gagagttact     2580

tgttcgttgc tcttccgact cggacctgag ttcgccaacg acccacttga ggtctgagcc     2640

ggtgaagaga agtaagcatc tcgttcgcag cttgccagca ctttcagaac atgaccccta     2700

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat     2760

aaatgcttca ataatattga aaaaggaaga gtggccgcct cggcctaggc ttttgcaaag     2820

atcgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     2880

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     2940

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     3000

aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg gctatcgtgg     3060

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     3120

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     3180

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     3240

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     3300

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     3360

ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt gacccatggc     3420

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     3480

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     3540

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     3600

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagg taccatgatg     3660

cgtgcatggt agaatgactc ttgataacgg acttcgacta ggcaatatcc cttgtcaact     3720

tgtcgaggag aaaagtattg actgaagcgc tcccggcaca acggccaaag aagtctcagc     3780

aatgttctta tttccgaatg acatgcgtct ccttgcgggt aaatcgccga ccgcaaaact     3840

taggagccag gatacagata ggtctaactt aggttaaggg agtaaatcct gggatcgttc     3900

agttgtaacc atatacttac gctggggctt ctccggcgga tgttactgtc accaaccacg     3960

agatttgaag taaacgcatg attgagcaca tagccgcgct atccgacaat ctccaaattg     4020

ataacatacc gttccatgaa ggccagaatt acttaccggc cctttccatg cgtgcgccat     4080

accgcactct gcgcttatcc gtccgagggg agagtgtgcg atcctccgtt aagatattct     4140

cacgtatgac gtagctatgt attgtgcaga ggtagcgaag gcgttgaaca cttcacagat     4200

ggtggggatt cgggcaaagg gcgtgataac ttggggacta acataggcgt aaactacgat     4260

ggcaccaact caatcgcagc tcgtgcgccc tgaatcaacg tactcatctc aactgattct     4320

cggcaatcta cggagcgact tgattatcaa cacctgtcta gcagttctaa tcttctgcca     4380

acatcgtaca tagcctccaa gagattatca tacctatcgg cacagaagtg acacgacgcc     4440

gaagggtagc ggacttctgg tcaaccacaa ttccccaggg gacaggtcct gcggtgcgca     4500

tcactttgta agtgcaagca acccaagtga gcccagcctg gactgagctg gttcctgtgt     4560

caggtcgagg ctggggatga cagctcttgt aaacatagtg atcaagcgtg gcgtcgaacg     4620

gtcgagaaac tcatagtacc tcgggtagca acttactcag gttattgctt gaagctgtac     4680

tatttcagga gcgctgaagg tctcttcttc tgtagactga actcgcaagg gtcgtgaagt     4740

cggttccttc aatgcttaac aagaacaaag gcttactgtg cagactggaa cgcccatcta     4800

gcggctcgcg tcttgaatgc tcggtcccct ttgtcattgc ggatacaatc catttccctc     4860

attcaccagc ttgcgaagtc tacattgagt agacgaatgc gacctagaag aggtgcgctt     4920

cagaacttgt gaggagtggt tgatgctcta tactccattt ggtgtttcgt gcatcaccgc     4980

gataggctga caagaggtct tgaacattga atagcaaggc acttccggtc tcatagaaga     5040

gagcacggga taaggtacgc gcgtggtacg ggaggatcaa ggggctacac gatagaaagg     5100

cttctccctc actcgctagg aggcaaatgc agaacgctgg ttactactac gatacgtgaa     5160

acttgtccaa cggttgccca aagtgttaag tgtctatcac cctagtgccg tttcccggag     5220

aaaacgccag gttgaatccg catttgaagc tacgatggtg aagtctgggt cgagcgcgcc     5280

gcatgttgat tgcgtgagta ggctcgacca agaaccgcta gtagcgtcgc tgtagaaata     5340

gttctcgaca gaccgtcgag tttagaaaat ggtagcagca ttgttcgcat ctcaatcaag     5400

tatggattac ggtgtttaca ctgtcctgcg gctacccatc gcctgaaatc cagctcgtgt     5460

caagccattg cctctccggg acgccgcatg aagtaactac atataccttg cacgggttga     5520

ctgcggtccg ttcagactcg accaaggaca caatccagcg atcggtgcgg gcctcttcgc     5580

tattacgcca g                                                          5591


