                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals S.A.
 
<120>  Vaccine

<130>  VB66043

<140>  1603029.8
<141>  2016-02-22

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Pneumolysin protein from S. pneumoniae

<400>  1

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  2
<211>  471
<212>  PRT
<213>  Pneumolysin protein from S. pneumoniae

<400>  2

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  3
<211>  471
<212>  PRT
<213>  Pneumolysin protein from S. pneumoniae

<400>  3

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  4
<211>  471
<212>  PRT
<213>  Pneumolysin protein from S. pneumoniae

<400>  4

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  5
<211>  471
<212>  PRT
<213>  Pneumolysin protein from S. pneumoniae

<400>  5

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  6
<211>  364
<212>  PRT
<213>  Protein D from H. influenzae

<400>  6

Met Lys Leu Lys Thr Leu Ala Leu Ser Leu Leu Ala Ala Gly Val Leu 
1               5                   10                  15      


Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys 
            20                  25                  30          


Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro 
        35                  40                  45              


Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln Gln Ala Asp 
    50                  55                  60                  


Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val 
65                  70                  75                  80  


Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe 
                85                  90                  95      


Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr 
            100                 105                 110         


Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys 
        115                 120                 125             


Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys 
    130                 135                 140                 


Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln 
145                 150                 155                 160 


Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile 
                165                 170                 175     


Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu 
            180                 185                 190         


Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met 
        195                 200                 205             


Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr 
    210                 215                 220                 


Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile 
225                 230                 235                 240 


Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr 
                245                 250                 255     


Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala 
            260                 265                 270         


Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu 
        275                 280                 285             


Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu 
    290                 295                 300                 


Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Val His Pro Tyr Thr Val 
305                 310                 315                 320 


Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln Met Tyr 
                325                 330                 335     


Asp Ala Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe 
            340                 345                 350         


Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys 
        355                 360                 


<210>  7
<211>  348
<212>  PRT
<213>  Artificial

<220>
<223>  Tripeptide MDP from NS1 fused to N-terminal of protein D from H. 
       influenzae

<400>  7

Met Asp Pro Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys 
1               5                   10                  15      


Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro 
            20                  25                  30          


Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln Gln Ala Asp 
        35                  40                  45              


Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val 
    50                  55                  60                  


Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe 
65                  70                  75                  80  


Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr 
                85                  90                  95      


Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys 
            100                 105                 110         


Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys 
        115                 120                 125             


Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln 
    130                 135                 140                 


Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile 
145                 150                 155                 160 


Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu 
                165                 170                 175     


Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met 
            180                 185                 190         


Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr 
        195                 200                 205             


Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile 
    210                 215                 220                 


Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr 
225                 230                 235                 240 


Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala 
                245                 250                 255     


Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu 
            260                 265                 270         


Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu 
        275                 280                 285             


Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Val His Pro Tyr Thr Val 
    290                 295                 300                 


Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln Met Tyr 
305                 310                 315                 320 


Asp Ala Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe 
                325                 330                 335     


Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys 
            340                 345             


<210>  8
<211>  10
<212>  PRT
<213>  Fragment of protein D from H. influenzae

<400>  8

Ser Ser His Ser Ser Asn Met Ala Asn Thr 
1               5                   10  


