                         SEQUENCE LISTING

<110>  ELI LILLY AND COMPANY
 
<120>  ANTI-CD11d ANTIBODIES AND USES THEREOF

<130>  P-20899

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LC


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at pos. 27 is Gln, Arg, or Glu

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa at pos. 53 is Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa at pos. 94 is Trp, Phe, or Gly

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Xaa Ser Ile Gly Thr Arg 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Xaa Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Ile Xaa Pro Thr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HC


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at pos. 30 is Thr, Tyr, or Gly

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa at pos. 55 is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa at pos. 101 is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa at pos. 101 is Tyr or His

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Xaa Gly Asp Thr Gly Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Xaa Xaa Tyr Gly Tyr Leu Asn Val Ala Met Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCVR


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at pos. 27 is Gln, Arg, or Glu

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa at pos. 53 is Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa at pos. 94 is Trp, Phe, or Gly

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Xaa Ser Ile Gly Thr Arg 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Xaa Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Ile Xaa Pro Thr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCVR


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at pos. 30 is Thr, Tyr, or Gly

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa at pos. 53 is Asn or Ser

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa at pos. 101 is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa at pos. 102 is Tyr or His

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Xaa Gly Asp Thr Gly Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Xaa Xaa Tyr Gly Tyr Leu Asn Val Ala Met Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR1


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at pos. 4 is Gln, Arg, or Glu

<400>  5

Arg Ala Ser Xaa Ser Ile Gly Thr Arg Ile His 
1               5                   10      


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at pos. 5 is Glu or Gly

<400>  6

Tyr Phe Ala Ser Xaa Ser Ile Ser 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at pos. 6 is Trp, Phe, or Gly

<400>  7

Gln Gln Ser Lys Ile Xaa Pro Thr Thr 
1               5                   


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR1


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at pos. 8 is Thr, Tyr, or Gly

<400>  8

Lys Ala Ser Gly Tyr Thr Phe Xaa Asp Tyr Asn Met His 
1               5                   10              


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR2


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at pos. 6 is Asn or Ser

<400>  9

Tyr Ile Tyr Pro Tyr Xaa Gly Asp Thr Gly Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at pos. 5 is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at pos. 6 is Tyr or His

<400>  10

Ala Arg Gly Leu Xaa Xaa Tyr Gly Tyr Leu Asn Val Ala Met Asp Ser 
1               5                   10                  15      


<210>  11
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence Encoding the Exemplified LC given by SEQ ID 
       NO: 1


<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  n at pos. 79 is c, a, or g

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  n at pos. 80 is a or g

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  n at pos. 81 is a or g

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  n at pos. 158 is a or g

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  n at pos. 280 is g or t

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  n at pos. 281 is g or t

<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  n at pos. 282 is g or t

<400>  11
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgca gggccagtnn nagcattggc acaagaatac actggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatttt gcttctgngt ctatctctgg agtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttacta ctgtcaacaa agtaaaatcn nnccaacgac gttcggcgga    300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gc                       642


<210>  12
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence Encoding the Exemplified HC given by SEQ ID 
       NO: 2


<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  n at pos. 88 is a, g, or t

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  n at pos. 89 is c, g, or a

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  n at pos. 90 is c, a, or t

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  n at pos. 163 is a or t

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  n at pos. 164 is a or c

<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  n at pos. 301 is a or g

<220>
<221>  misc_feature
<222>  (303)..(303)
<223>  n at pos. 303 is c or t

<220>
<221>  misc_feature
<222>  (304)..(304)
<223>  n at pos. 304 is t or c

<220>
<221>  misc_feature
<222>  (306)..(306)
<223>  n at pos. 306 is c or t

<400>  12
caggtgcagc tggtgcagtc tggtgctgaa gtgaagaagc ctggggcctc agtgaaggtg     60

tcctgcaagg catctggata cacattcnnn gactacaaca tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatat atttatcctt acnntggtga tactgggtac    180

aaccagaatt tcaagagcag agtcaccatg accagggaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggatta    300

ntnnantacg gctaccttaa cgttgctatg gactcctggg gccaagggac actagtcaca    360

gtctcctcag cctccaccaa gggcccatcg gtcttcccgc tagcgccctg ctccaggagc    420

acctccgaga gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta    540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc    600

acgaagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga    660

gttgagtcca aatatggtcc cccatgccca ccctgcccag cacctgaggc cgccggggga    720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct    780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg    840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac    900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag    960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc   1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag   1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc   1140

gccgtggagt gggaaagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg   1200

ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa gagcaggtgg   1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca   1320

cagaagagcc tctccctgtc tctgggt                                       1347


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified LCDR1


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is an acyclic, polar amino acid with a charged 
       entity

<400>  13

Arg Ala Ser Xaa Ser Ile Gly Thr Arg Ile His 
1               5                   10      


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified LCDR2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is an acyclic amino acid

<400>  14

Tyr Phe Ala Ser Xaa Ser Ile Ser 
1               5               


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified LCDR3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 may be a neutral hydrophobic amino acid

<400>  15

Gln Gln Ser Lys Ile Xaa Pro Thr Thr 
1               5                   


<210>  16
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified HCDR1


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 may be a neutral polar or nonpolar amino acid

<400>  16

Lys Ala Ser Gly Tyr Thr Phe Xaa Asp Tyr Asn Met His 
1               5                   10              


<210>  17
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified HCDR2


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 may be an acyclic, neutral, polar amino acid

<400>  17

Tyr Ile Tyr Pro Tyr Xaa Gly Asp Thr Gly Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplified HCDR3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 may be an acyclic, hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 may be a cyclic, aromatic amino acid

<400>  18

Ala Arg Gly Leu Xaa Xaa Tyr Gly Tyr Leu Asn Val Ala Met Asp Ser 
1               5                   10                  15      


