                         SEQUENCE LISTING

<110>  Dignity Health
 
<120>  Antibody Fusion Protein and Related Compositions

<130>  DH-007WO00

<150>  62/297,502
<151>  2016-02-19

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Trp Val Trp Thr Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  3
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr 
        35                  40                  45              


Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp 
65                  70                  75                  80  


Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe 
                85                  90                  95      


Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105     


<210>  4
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
        115                 120                 125             


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in laboratory

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  36
<212>  PRT
<213>  Leiurus quinquestriatus

<400>  6

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in laboratory

<400>  7

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Arg Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in laboratory

<400>  8

Gly Gly Gly Gly Ser 
1               5   


<210>  9
<211>  293
<212>  PRT
<213>  Recombinant

<400>  9

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser 
        35                  40                  45              


Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser 
    130                 135                 140                 


Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile Ser 
145                 150                 155                 160 


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
    210                 215                 220                 


Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala 
                245                 250                 255     


Arg Lys Cys Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr 
            260                 265                 270         


Gly Pro Gln Cys Leu Cys Arg Leu Glu Val Leu Phe Gln Gly Pro His 
        275                 280                 285             


His His His His His 
    290             


<210>  10
<211>  293
<212>  PRT
<213>  Recombinant

<400>  10

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser 
        35                  40                  45              


Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser 
    130                 135                 140                 


Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile Ser 
145                 150                 155                 160 


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
    210                 215                 220                 


Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala 
                245                 250                 255     


Arg Lys Cys Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Arg Cys Tyr 
            260                 265                 270         


Gly Pro Gln Cys Leu Cys Arg Leu Glu Val Leu Phe Gln Gly Pro His 
        275                 280                 285             


His His His His His 
    290             


<210>  11
<211>  336
<212>  PRT
<213>  Recombinant

<400>  11

Met Asp Trp Val Trp Thr Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Phe Gln Val Gln Ile 
145                 150                 155                 160 


Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Ile Ser Arg Gly Gln 
                165                 170                 175     


Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            180                 185                 190         


Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
        195                 200                 205             


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
    210                 215                 220                 


Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly 
225                 230                 235                 240 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp 
                245                 250                 255     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe 
            260                 265                 270         


Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Gly Gly Ser Met Cys 
        275                 280                 285             


Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys Asp Asp 
    290                 295                 300                 


Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln Cys Leu 
305                 310                 315                 320 


Cys Arg Leu Glu Val Leu Phe Gln Gly Pro His His His His His His 
                325                 330                 335     


<210>  12
<211>  336
<212>  PRT
<213>  Recombinant

<400>  12

Met Asp Trp Val Trp Thr Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Phe Gln Val Gln Ile 
145                 150                 155                 160 


Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Ile Ser Arg Gly Gln 
                165                 170                 175     


Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            180                 185                 190         


Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
        195                 200                 205             


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
    210                 215                 220                 


Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly 
225                 230                 235                 240 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp 
                245                 250                 255     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe 
            260                 265                 270         


Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Gly Gly Ser Met Cys 
        275                 280                 285             


Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys Asp Asp 
    290                 295                 300                 


Cys Cys Gly Gly Lys Gly Arg Gly Arg Cys Tyr Gly Pro Gln Cys Leu 
305                 310                 315                 320 


Cys Arg Leu Glu Val Leu Phe Gln Gly Pro His His His His His His 
                325                 330                 335     


<210>  13
<211>  882
<212>  DNA
<213>  Recombinant

<400>  13
atggaggttc agcttgttga gtctggtgga ggtttggtgc aacctggaaa gtccctcaag       60

ctctcctgtg aggcctctgg attcaccttc agcggttacg gcatgcactg ggtcaggcaa      120

gctccaggta ggggtctcga gagcgtggcc tacattacta gctccagtat taacatcaaa      180

tacgctgacg ctgtgaaggg taggttcacc gtgtccagag acaacgccaa gaacttgctc      240

ttccttcaga tgaacattct caagtctgag gacacagcca tgtactactg tgctagattc      300

gactgggaca aaaattactg gggccaagga acaatggtca ccgtttcctc aggaggagga      360

ggatcaggag gaggaggatc aggaggagga ggatcacaga tgacccagtc tccatcatca      420

ctccctgcct ccctcggaga cagagttact atcaactgtc aggccagcca ggacattagc      480

aattacttga actggtacca gcaaaagcca ggtaaggctc ctaagctcct catctactat      540

acaaacaagt tggccgatgg agtgccatca aggttcagcg gttctggttc tggaagagat      600

tcttctttca ctatctccag cctcgaatcc gaagatattg gatcttacta ctgtcaacag      660

tactacaact atccgtggac attcggacct ggtaccaagc tcgaaatcaa gaggggagga      720

ggaggatcaa tgtgtatgcc ttgctttaca acggatcatc agatggcaag gaagtgtgac      780

gactgttgtg gaggcaaggg aaggggaaag tgttacggcc cacaatgtct ctgtcgtctt      840

gaggttctct tccaaggacc tcaccatcac catcaccatt aa                         882


