                         SEQUENCE LISTING

<110>  Research Development Foundation
 
<120>  SORTASE-MODIFIED MOLECULES AND USES THEREOF

<130>  CLFR.P0445WO

<140>  Not Yet Assigned
<141>  2017-02-16

<150>  62/295,636
<151>  2016-02-16

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  1
atcatcgggg gacatgaggc caagccccac tcccgcccct acatggctta tcttatgatc       60

tgggatcaga agtctctgaa gaggtgcggt ggcttcctga tacaagacga cttcgtgctg      120

acagctgctc actgttgggg aagctccata aatgtcacct tgggggccca caatatcaaa      180

gaacaggagc cgacccagca gtttatccct gtgaaaagac ccatccccca tccagcctat      240

aatcctaaga acttctccaa cgacatcatg ctactgcagc tggagagaaa ggccaagcgg      300

accagagctg tgcagcccct caggctacct agcaacaagg cccaggtgaa gccagggcag      360

acatgcagtg tggccggctg ggggcagacg gcccccctgg gaaaacactc acacacacta      420

caagaggtga agatgacagt gcaggaagat cgaaagtgcg aatctgactt acgccattat      480

tacgacagta ccattgagtt gtgcgtgggg gacccagaga ttaaaaagac ttcctttaag      540

ggggactctg gaggccctct tgtgtgtaac aaggtggccc agggcattgt ctcctatgga      600

cgaaacaatg gcatgcctcc acgagcctgc accaaagtct caagctttgt acactggata      660

aagaaaacca tgaaacgcta cggtggcggt ggctccggtg gcggtggctc cctcccggaa      720

acgggtgga                                                              729


<210>  2
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Gln Asp Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Glu 
225                 230                 235                 240 


Thr Gly Gly 
            


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg Tyr 
225         


<210>  4
<211>  227
<212>  PRT
<213>  Pan troglodytes

<400>  4

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Thr Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Tyr Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Val Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Pan paniscus

<400>  5

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Thr Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Tyr Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Ala Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  6
<211>  227
<212>  PRT
<213>  Pongo abelii

<400>  6

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Gln 
    50                  55                  60                  


Thr Gln Gln Leu Ile Pro Val Lys Arg Ala Val Arg His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Lys 
                85                  90                  95      


Lys Ala Lys Arg Thr Thr Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Ala Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Thr Gly Lys Tyr Ser His Thr Leu Gln Glu Val Glu 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Lys Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Ala Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Val Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  7
<211>  227
<212>  PRT
<213>  Macaca nemestrina

<400>  7

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Met Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Arg 
    50                  55                  60                  


Thr Gln Gln Ile Ile Pro Val Lys Arg Ala Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Glu Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Thr Ala Val Gln Pro Leu Arg Leu Pro Arg Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Ala Cys Asp Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Thr Pro Asp Gly Lys Tyr Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Leu Thr Val Glu Glu Asp Gln Thr Cys Lys Ser Arg Leu Gly His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Val Glu Leu Cys Val Gly Asp Pro Glu Ile Gln Lys 
                165                 170                 175     


Ala Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Gln Arg Asn Gly Lys Pro Pro Arg 
        195                 200                 205             


Val Cys Thr Lys Val Ser Ser Phe Val Arg Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  8
<211>  227
<212>  PRT
<213>  Macaca mulatta

<400>  8

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Met Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Arg 
    50                  55                  60                  


Thr Gln Gln Ile Ile Pro Val Lys Arg Ala Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Thr Ala Val Lys Pro Leu Arg Leu Pro Arg Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Ala Cys Asp Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Thr Pro Asp Gly Lys Tyr Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Leu Thr Val Glu Glu Asp Gln Thr Cys Lys Ser Arg Leu Gly Arg Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Val Glu Leu Cys Val Gly Asp Pro Glu Ile Gln Lys 
                165                 170                 175     


Ala Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Gln Arg Asn Gly Lys Pro Pro Arg 
        195                 200                 205             


Val Cys Thr Lys Val Ser Ser Phe Val Arg Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  9
<211>  227
<212>  PRT
<213>  Macaca fascicularis

<400>  9

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Met Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Arg 
    50                  55                  60                  


Thr Gln Gln Ile Ile Pro Val Lys Arg Ala Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Thr Ala Val Lys Pro Leu Arg Leu Pro Arg Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Ala Cys Asp Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Thr Pro Asp Gly Lys Tyr Ala His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Leu Thr Val Glu Glu Asp Gln Thr Cys Lys Ser Arg Leu Gly Arg Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Val Glu Leu Cys Val Gly Asp Pro Glu Ile Gln Lys 
                165                 170                 175     


Ala Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Gln Arg Asn Gly Lys Pro Pro Arg 
        195                 200                 205             


Val Cys Thr Lys Val Ser Ser Phe Val Arg Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg His 
225         


<210>  10
<211>  226
<212>  PRT
<213>  Sus scrofa

<400>  10

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Gln Ile Gln Asp Gln Asp Asn Arg Ser Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Lys Gln Glu Glu 
    50                  55                  60                  


Thr Gln Gln Val Ile Pro Val Arg Lys Ala Ile Arg His Pro Asp Tyr 
65                  70                  75                  80  


Asn Glu Lys Arg Ile Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Leu Thr Lys Ala Val Lys Thr Leu Gly Leu Pro Gly Ala 
            100                 105                 110         


Lys Ala Arg Val Lys Pro Gly Gln Val Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Val Glu Arg Gly Ile Tyr Thr Asp Thr Leu Gln Glu Val Lys Leu 
    130                 135                 140                 


Thr Leu Gln Lys Asp Gln Glu Cys Asp Ser Tyr Leu Pro Asn Tyr Tyr 
145                 150                 155                 160 


Asn Gly Asn Thr Gln Leu Cys Val Gly Asp Pro Lys Lys Lys Gln Ala 
                165                 170                 175     


Thr Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Asn Val Ala 
            180                 185                 190         


Gln Gly Ile Val Ser Tyr Gly Lys Lys Asp Gly Thr Pro Pro Arg Ala 
        195                 200                 205             


Cys Thr Lys Val Ser Ser Phe Leu Pro Trp Ile Lys Lys Ile Met Lys 
    210                 215                 220                 


Ser Leu 
225     


<210>  11
<211>  226
<212>  PRT
<213>  Bos taurus

<400>  11

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Gln Tyr Trp Asn Gln Asp Val Gln Ser Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Val Arg Gln Asp Phe Val Leu Thr Ala Ala His Cys Asn Gly Ser 
        35                  40                  45              


Ser Ile Lys Val Thr Leu Gly Ala His Asn Ile Lys Gln Gln Glu Arg 
    50                  55                  60                  


Thr Gln Gln Val Ile Arg Val Arg Arg Ala Ile Ser His Pro Asp Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Lys Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Gln Thr Ser Ala Val Lys Pro Leu Ser Leu Pro Arg Ala 
            100                 105                 110         


Lys Ala Arg Val Lys Pro Gly Gln Thr Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Arg Asp Ser Thr Asp Thr Tyr Ala Asp Thr Leu Gln Glu Val Lys Leu 
    130                 135                 140                 


Ile Val Gln Glu Asp Gln Lys Cys Glu Ala Tyr Leu Arg Asn Phe Tyr 
145                 150                 155                 160 


Asn Arg Ala Ile Gln Leu Cys Val Gly Asp Pro Lys Thr Lys Lys Ala 
                165                 170                 175     


Ser Phe Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Asn Val Ala 
            180                 185                 190         


Gln Gly Ile Val Ser Tyr Gly Lys Arg Asp Gly Ser Thr Pro Arg Ala 
        195                 200                 205             


Phe Thr Lys Val Ser Ser Phe Leu Pro Trp Ile Lys Lys Thr Met Lys 
    210                 215                 220                 


Ser Leu 
225     


<210>  12
<211>  228
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Gln Ile Met Asp Glu Tyr Ser Gly Ser Lys Lys Cys Gly Gly 
            20                  25                  30          


Phe Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Ser Gly 
        35                  40                  45              


Ser Lys Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu 
    50                  55                  60                  


Lys Met Gln Gln Ile Ile Pro Val Val Lys Ile Ile Pro His Pro Ala 
65                  70                  75                  80  


Tyr Asn Ser Lys Thr Ile Ser Asn Asp Ile Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Ser Lys Ala Lys Arg Ser Ser Ala Val Lys Pro Leu Asn Leu Pro Arg 
            100                 105                 110         


Arg Asn Val Lys Val Lys Pro Gly Asp Val Cys Tyr Val Ala Gly Trp 
        115                 120                 125             


Gly Lys Leu Gly Pro Met Gly Lys Tyr Ser Asp Thr Leu Gln Glu Val 
    130                 135                 140                 


Glu Leu Thr Val Gln Glu Asp Gln Lys Cys Glu Ser Tyr Leu Lys Asn 
145                 150                 155                 160 


Tyr Phe Asp Lys Ala Asn Glu Ile Cys Ala Gly Asp Pro Lys Ile Lys 
                165                 170                 175     


Arg Ala Ser Phe Arg Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Lys 
            180                 185                 190         


Val Ala Ala Gly Ile Val Ser Tyr Gly Gln Asn Asp Gly Ser Thr Pro 
        195                 200                 205             


Arg Ala Phe Thr Lys Val Ser Thr Phe Leu Ser Trp Ile Lys Lys Thr 
    210                 215                 220                 


Met Lys Lys Ser 
225             


<210>  13
<211>  227
<212>  PRT
<213>  Mus musculus

<400>  13

Ile Ile Gly Gly His Glu Val Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Leu Leu Ser Ile Lys Asp Gln Gln Pro Glu Ala Ile Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Glu Gly Ser 
        35                  40                  45              


Ile Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Lys 
    50                  55                  60                  


Thr Gln Gln Val Ile Pro Met Val Lys Cys Ile Pro His Pro Asp Tyr 
65                  70                  75                  80  


Asn Pro Lys Thr Phe Ser Asn Asp Ile Met Leu Leu Lys Leu Lys Ser 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Arg Pro Leu Asn Leu Pro Arg Arg 
            100                 105                 110         


Asn Val Asn Val Lys Pro Gly Asp Val Cys Tyr Val Ala Gly Trp Gly 
        115                 120                 125             


Arg Met Ala Pro Met Gly Lys Tyr Ser Asn Thr Leu Gln Glu Val Glu 
    130                 135                 140                 


Leu Thr Val Gln Lys Asp Arg Glu Cys Glu Ser Tyr Phe Lys Asn Arg 
145                 150                 155                 160 


Tyr Asn Lys Thr Asn Gln Ile Cys Val Gly Asp Pro Lys Thr Lys Arg 
                165                 170                 175     


Ala Ser Phe Arg Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Lys Val 
            180                 185                 190         


Ala Ala Gly Ile Val Ser Tyr Gly Tyr Lys Asp Gly Ser Pro Pro Arg 
        195                 200                 205             


Ala Phe Thr Lys Val Ser Ser Phe Leu Ser Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Ser Ser 
225         


<210>  14
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  14

Ile Ile Gly Gly Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val 
1               5                   10                  15      


Leu Leu Ser Leu Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala 
            20                  25                  30          


Lys Asp Trp Val Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser 
        35                  40                  45              


Gln Val Ile Leu Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys 
    50                  55                  60                  


Gln Ile Met Leu Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Ala Thr Arg Glu Gly Asp Leu Lys Leu Leu Gln Leu Met Glu Lys Ala 
                85                  90                  95      


Lys Ile Asn Lys Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp 
            100                 105                 110         


Asp Val Lys Pro Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr 
        115                 120                 125             


His Asn Ser Ala Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr 
    130                 135                 140                 


Ile Ile Asp Arg Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn 
145                 150                 155                 160 


Pro Val Ile Gly Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly 
                165                 170                 175     


Arg Asp Ser Cys Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly 
            180                 185                 190         


Val Phe Arg Gly Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp 
        195                 200                 205             


Pro Arg Gly Pro Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn 
    210                 215                 220                 


Trp Ile Ile Met Thr Ile Lys Gly Ala Val 
225                 230                 


<210>  15
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  15

Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg Cys Gly Gly Ile 
            20                  25                  30          


Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His Cys Gln Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Arg 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Trp Thr Thr Ala Val Arg Pro Leu Arg Leu Pro Ser Ser 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Leu Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Tyr Val Ser Met Ser Thr Leu Ala Thr Thr Leu Gln Glu Val Leu Leu 
    130                 135                 140                 


Thr Val Gln Lys Asp Cys Gln Cys Glu Arg Leu Phe His Gly Asn Tyr 
145                 150                 155                 160 


Ser Arg Ala Thr Glu Ile Cys Val Gly Asp Pro Lys Lys Thr Gln Thr 
                165                 170                 175     


Gly Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Asp Val Ala 
            180                 185                 190         


Gln Gly Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr Pro Pro Gly Val 
        195                 200                 205             


Tyr Ile Lys Val Ser His Phe Leu Pro Trp Ile Lys Arg Thr Met Lys 
    210                 215                 220                 


Arg Leu 
225     


<210>  16
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Ile Gly Gly Lys Glu Val Ser Pro His Ser Arg Pro Phe Met Ala 
1               5                   10                  15      


Ser Ile Gln Tyr Gly Gly His His Val Cys Gly Gly Val Leu Ile Asp 
            20                  25                  30          


Pro Gln Trp Val Leu Thr Ala Ala His Cys Gln Tyr Arg Phe Thr Lys 
        35                  40                  45              


Gly Gln Ser Pro Thr Val Val Leu Gly Ala His Ser Leu Ser Lys Asn 
    50                  55                  60                  


Glu Ala Ser Lys Gln Thr Leu Glu Ile Lys Lys Phe Ile Pro Phe Ser 
65                  70                  75                  80  


Arg Val Thr Ser Asp Pro Gln Ser Asn Asp Ile Met Leu Val Lys Leu 
                85                  90                  95      


Gln Thr Ala Ala Lys Leu Asn Lys His Val Lys Met Leu His Ile Arg 
            100                 105                 110         


Ser Lys Thr Ser Leu Arg Ser Gly Thr Lys Cys Lys Val Thr Gly Trp 
        115                 120                 125             


Gly Ala Thr Asp Pro Asp Ser Leu Arg Pro Ser Asp Thr Leu Arg Glu 
    130                 135                 140                 


Val Thr Val Thr Val Leu Ser Arg Lys Leu Cys Asn Ser Gln Ser Tyr 
145                 150                 155                 160 


Tyr Asn Gly Asp Pro Phe Ile Thr Lys Asp Met Val Cys Ala Gly Asp 
                165                 170                 175     


Ala Lys Gly Gln Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


Ile Cys Lys Gly Val Phe His Ala Ile Val Ser Gly Gly His Glu Cys 
        195                 200                 205             


Gly Val Ala Thr Lys Pro Gly Ile Tyr Thr Leu Leu Thr Lys Lys Tyr 
    210                 215                 220                 


Gln Thr Trp Ile Lys Ser Asn Leu Val Pro Pro His Thr Asn 
225                 230                 235             


<210>  17
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Ile Gly Gly Arg Glu Val Ile Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Leu Gln Arg Asn Gly Ser His Leu Cys Gly Gly Val Leu Val His 
            20                  25                  30          


Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Ala Gln Arg Met Ala 
        35                  40                  45              


Gln Leu Arg Leu Val Leu Gly Leu His Thr Leu Asp Ser Pro Gly Leu 
    50                  55                  60                  


Thr Phe His Ile Lys Ala Ala Ile Gln His Pro Arg Tyr Lys Pro Val 
65                  70                  75                  80  


Pro Ala Leu Glu Asn Asp Leu Ala Leu Leu Gln Leu Asp Gly Lys Val 
                85                  90                  95      


Lys Pro Ser Arg Thr Ile Arg Pro Leu Ala Leu Pro Ser Lys Arg Gln 
            100                 105                 110         


Val Val Ala Ala Gly Thr Arg Cys Ser Met Ala Gly Trp Gly Leu Thr 
        115                 120                 125             


His Gln Gly Gly Arg Leu Ser Arg Val Leu Arg Glu Leu Asp Leu Gln 
    130                 135                 140                 


Val Leu Asp Thr Arg Met Cys Asn Asn Ser Arg Phe Trp Asn Gly Ser 
145                 150                 155                 160 


Leu Ser Pro Ser Met Val Cys Leu Ala Ala Asp Ser Lys Asp Gln Ala 
                165                 170                 175     


Pro Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Lys Gly Arg 
            180                 185                 190         


Val Leu Ala Arg Val Leu Ser Phe Ser Ser Arg Val Cys Thr Asp Ile 
        195                 200                 205             


Phe Lys Pro Pro Val Ala Thr Ala Val Ala Pro Tyr Val Ser Trp Ile 
    210                 215                 220                 


Arg Lys Val Thr Gly Arg Ser Ala 
225                 230         


<210>  18
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln Arg Arg Glu Asn 
    50                  55                  60                  


Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg His Pro Gln Tyr 
65                  70                  75                  80  


Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu Gln Leu Ser Arg 
                85                  90                  95      


Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala Leu Pro Arg Ala 
            100                 105                 110         


Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val Ala Gly Trp Gly 
        115                 120                 125             


Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg Glu Val Gln Leu 
    130                 135                 140                 


Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe Gly Ser Tyr Asp 
145                 150                 155                 160 


Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu Arg Lys Ala Ala 
                165                 170                 175     


Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn Asn Val Ala His 
            180                 185                 190         


Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro Pro Glu Val Phe 
        195                 200                 205             


Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr Thr Met Arg Ser 
    210                 215                 220                 


Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu 
225                 230                 235 


<210>  19
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser Lys Phe Cys Gly Gly 
            20                  25                  30          


Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala Ala His Cys Ala Gly 
        35                  40                  45              


Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn Ile Thr Glu Glu Glu 
    50                  55                  60                  


Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln Phe Arg His Pro Lys 
65                  70                  75                  80  


Tyr Asn Thr Ser Thr Leu His His Asp Ile Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr Leu Pro Phe Pro Ser 
            100                 105                 110         


Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys Arg Val Ala Gly Trp 
        115                 120                 125             


Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp Thr Leu Gln Glu Val 
    130                 135                 140                 


Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser His Phe Arg Asp Phe 
145                 150                 155                 160 


Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro Arg Lys Thr Lys Ser 
                165                 170                 175     


Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Ala Gly Val Ala 
            180                 185                 190         


Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala Lys Pro Pro Ala Val 
        195                 200                 205             


Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile Asn Gln Ile Leu Gln 
    210                 215                 220                 


Ala Asn 
225     


<210>  20
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  20

Ile Val Gly Gly His Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Leu Gln Met Arg Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr 
            20                  25                  30          


Leu Ile His Pro Ser Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp 
        35                  40                  45              


Ile Pro Gln Arg Leu Val Asn Val Val Leu Gly Ala His Asn Val Arg 
    50                  55                  60                  


Thr Gln Glu Pro Thr Gln Gln His Phe Ser Val Ala Gln Val Phe Leu 
65                  70                  75                  80  


Asn Asn Tyr Asp Ala Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln 
                85                  90                  95      


Leu Ser Ser Pro Ala Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu 
            100                 105                 110         


Pro Gln Gln Asp Gln Pro Val Pro His Gly Thr Gln Cys Leu Ala Met 
        115                 120                 125             


Gly Trp Gly Arg Val Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln 
    130                 135                 140                 


Glu Leu Asn Val Thr Val Val Thr Phe Phe Cys Arg Pro His Asn Ile 
145                 150                 155                 160 


Cys Thr Phe Val Pro Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Ile Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe 
            180                 185                 190         


Val Ile Trp Gly Cys Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg 
        195                 200                 205             


Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu 
    210                 215                 220                 


Ala Lys Gly Arg Pro 
225                 


<210>  21
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile Ile Gly Gly His Thr Cys Thr Arg Ser Ser Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Leu Ala Gly Pro Arg Arg Arg Phe Leu Cys Gly Gly Ala Leu 
            20                  25                  30          


Leu Ser Gly Gln Trp Val Ile Thr Ala Ala His Cys Gly Arg Pro Ile 
        35                  40                  45              


Leu Gln Val Ala Leu Gly Lys His Asn Leu Arg Arg Trp Glu Ala Thr 
    50                  55                  60                  


Gln Gln Val Leu Arg Val Val Arg Gln Val Thr His Pro Asn Tyr Asn 
65                  70                  75                  80  


Ser Arg Thr His Asp Asn Asp Leu Met Leu Leu Gln Leu Gln Gln Pro 
                85                  90                  95      


Ala Arg Ile Gly Arg Ala Val Arg Pro Ile Glu Val Thr Gln Ala Cys 
            100                 105                 110         


Ala Ser Pro Gly Thr Ser Cys Arg Val Ser Gly Trp Gly Thr Ile Ser 
        115                 120                 125             


Ser Pro Ile Ala Arg Tyr Pro Ala Ser Leu Gln Cys Val Asn Ile Asn 
    130                 135                 140                 


Ile Ser Pro Asp Glu Val Cys Gln Lys Ala Tyr Pro Arg Thr Ile Thr 
145                 150                 155                 160 


Pro Gly Met Val Cys Ala Gly Val Pro Gln Gly Gly Lys Asp Ser Cys 
                165                 170                 175     


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Arg Gly Gln Leu Gln Gly 
            180                 185                 190         


Leu Val Ser Trp Gly Met Glu Arg Cys Ala Leu Pro Gly Tyr Pro Gly 
        195                 200                 205             


Val Tyr Thr Asn Leu Cys Lys Tyr Arg Ser Trp Ile Glu Glu Thr Met 
    210                 215                 220                 


Arg Asp Lys 
225         


<210>  22
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 
            20                  25                  30          


Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 
        35                  40                  45              


Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 
    50                  55                  60                  


Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 
65                  70                  75                  80  


Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 
                85                  90                  95      


Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 
            100                 105                 110         


Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 
        115                 120                 125             


Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 
    130                 135                 140                 


Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 
145                 150                 155                 160 


Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 
                165                 170                 175     


Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 
            180                 185                 190         


Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 
        195                 200                 205             


Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 
    210                 215                 220                 


Ser Val Leu Ala 
225             


<210>  23
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Val Gly Gly Tyr Thr Cys Glu Glu Asn Ser Leu Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Ser His Phe Cys Gly Gly Ser Leu Ile Ser Glu 
            20                  25                  30          


Gln Trp Val Val Ser Ala Ala His Cys Tyr Lys Thr Arg Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Lys Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Ala Lys Ile Ile Arg His Pro Gln Tyr Asp Arg Lys Thr 
65                  70                  75                  80  


Leu Asn Asn Asp Ile Met Leu Ile Lys Leu Ser Ser Arg Ala Val Ile 
                85                  90                  95      


Asn Ala Arg Val Ser Thr Ile Ser Leu Pro Thr Ala Pro Pro Ala Thr 
            100                 105                 110         


Gly Thr Lys Cys Leu Ile Ser Gly Trp Gly Asn Thr Ala Ser Ser Gly 
        115                 120                 125             


Ala Asp Tyr Pro Asp Glu Leu Gln Cys Leu Asp Ala Pro Val Leu Ser 
    130                 135                 140                 


Gln Ala Lys Cys Glu Ala Ser Tyr Pro Gly Lys Ile Thr Ser Asn Met 
145                 150                 155                 160 


Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly Val Val Ser 
            180                 185                 190         


Trp Gly Asp Gly Cys Ala Gln Lys Asn Lys Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Tyr Asn Tyr Val Lys Trp Ile Lys Asn Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  24
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Val Gly Gly Tyr Asn Cys Glu Glu Asn Ser Val Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Tyr His Phe Cys Gly Gly Ser Leu Ile Asn Glu 
            20                  25                  30          


Gln Trp Val Val Ser Ala Gly His Cys Tyr Lys Ser Arg Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Glu Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Ala Lys Ile Ile Arg His Pro Gln Tyr Asp Arg Lys Thr 
65                  70                  75                  80  


Leu Asn Asn Asp Ile Met Leu Ile Lys Leu Ser Ser Arg Ala Val Ile 
                85                  90                  95      


Asn Ala Arg Val Ser Thr Ile Ser Leu Pro Thr Ala Pro Pro Ala Thr 
            100                 105                 110         


Gly Thr Lys Cys Leu Ile Ser Gly Trp Gly Asn Thr Ala Ser Ser Gly 
        115                 120                 125             


Ala Asp Tyr Pro Asp Glu Leu Gln Cys Leu Asp Ala Pro Val Leu Ser 
    130                 135                 140                 


Gln Ala Lys Cys Glu Ala Ser Tyr Pro Gly Lys Ile Thr Ser Asn Met 
145                 150                 155                 160 


Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly Val Val Ser 
            180                 185                 190         


Trp Gly Asp Gly Cys Ala Gln Lys Asn Lys Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Tyr Asn Tyr Val Lys Trp Ile Lys Asn Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  25
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  25

Ile Ile Gly Gly His Glu Val Thr Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Val Arg Phe Gly Gly Gln His His Cys Gly Gly Phe Leu Leu Arg 
            20                  25                  30          


Ala Arg Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp Leu 
        35                  40                  45              


Arg Thr Gly Leu Val Val Leu Gly Ala His Val Leu Ser Thr Ala Glu 
    50                  55                  60                  


Pro Thr Gln Gln Val Phe Gly Ile Asp Ala Leu Thr Thr His Pro Asp 
65                  70                  75                  80  


Tyr His Pro Met Thr His Ala Asn Asp Ile Cys Leu Leu Arg Leu Asn 
                85                  90                  95      


Gly Ser Ala Val Leu Gly Pro Ala Val Gly Leu Leu Arg Pro Pro Gly 
            100                 105                 110         


Arg Arg Ala Arg Pro Pro Thr Ala Gly Thr Arg Cys Arg Val Ala Gly 
        115                 120                 125             


Trp Gly Phe Val Ser Asp Phe Glu Glu Leu Pro Pro Gly Leu Met Glu 
    130                 135                 140                 


Ala Lys Val Arg Val Leu Asp Pro Asp Val Cys Asn Ser Ser Trp Lys 
145                 150                 155                 160 


Gly His Leu Thr Leu Thr Met Leu Cys Thr Arg Ser Gly Asp Ser His 
                165                 170                 175     


Arg Arg Gly Phe Cys Ser Ala Asp Ser Gly Gly Pro Leu Val Cys Arg 
            180                 185                 190         


Asn Arg Ala His Gly Leu Val Ser Phe Ser Gly Leu Trp Cys Gly Asp 
        195                 200                 205             


Pro Lys Thr Pro Asp Val Tyr Thr Gln Val Ser Ala Phe Val Ala Trp 
    210                 215                 220                 


Ile Trp Asp Val Val Arg Arg Ser Ser Pro Gln Pro Gly Pro Leu Pro 
225                 230                 235                 240 


Gly Thr Thr Arg Pro Pro Gly Glu Ala Ala 
                245                 250 


<210>  26
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Ile Gly Gly His Glu Val Thr Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Val Arg Phe Gly Gly Gln His His Cys Gly Gly Phe Leu Leu Arg 
            20                  25                  30          


Ala Arg Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp Leu 
        35                  40                  45              


Arg Thr Gly Leu Val Val Leu Gly Ala His Val Leu Ser Thr Ala Glu 
    50                  55                  60                  


Pro Thr Gln Gln Val Phe Gly Ile Asp Ala Leu Thr Thr His Pro Asp 
65                  70                  75                  80  


Tyr His Pro Met Thr His Ala Asn Asp Ile Cys Leu Leu Arg Leu Asn 
                85                  90                  95      


Gly Ser Ala Val Leu Gly Pro Ala Val Gly Leu Leu Arg Leu Pro Gly 
            100                 105                 110         


Arg Arg Ala Arg Pro Pro Thr Ala Gly Thr Arg Cys Arg Val Ala Gly 
        115                 120                 125             


Trp Gly Phe Val Ser Asp Phe Glu Glu Leu Pro Pro Gly Leu Met Glu 
    130                 135                 140                 


Ala Lys Val Arg Val Leu Asp Pro Asp Val Phe Asn Ser Ser Trp Lys 
145                 150                 155                 160 


Gly His Leu Thr Leu Thr Met Leu Cys Thr Arg Ser Gly Asp Ser His 
                165                 170                 175     


Arg Arg Gly Phe Cys Ser Ala Asp Ser Gly Gly Pro Leu Val Cys Arg 
            180                 185                 190         


Asn Arg Ala His Gly Leu Val Ser Phe Ser Gly Leu Trp Cys Gly Asp 
        195                 200                 205             


Pro Lys Thr Pro Asp Val Tyr Thr Gln Val Ser Ala Phe Val Ala Trp 
    210                 215                 220                 


Ile Trp Asp Val Val Arg Arg Ser Ser Pro Gln Pro Gly Pro Leu Pro 
225                 230                 235                 240 


Gly Thr Thr Arg Pro Pro Gly Glu Ala Ala 
                245                 250 


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  29
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Thr Gln Ile Glu Asn Leu Lys Glu Lys Gly 
1               5                   10  


<210>  32
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala 
            20                  25      


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Glu Gly Trp Tyr Gly Cys Gly 
            20                  25  


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Glu Ala Ala Ala Lys 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Gly Gly Gly Gly Ser 
1               5   


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Gln Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


