                         SEQUENCE LISTING

<110>  Albert Einstein College of Medicine, Inc.
 
<120>  DENGUE VIRUS GLYCOPROTEIN E DIII VARIANTS AND USES THEREOF

<130>  96700/2436

<140>  PCT/US2017/17637
<141>  2017-02-13

<150>  US 62/295,634
<151>  2016-02-16

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Ser Thr Ser His 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Val Glu Ser Ser Gln Leu Ser Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  2
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  2

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Ser Ser Ser 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Tyr Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Val Glu Ser Ala Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  3
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  3

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Ala Ala Ala Ala 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Val Ala Pro Gly Gln Leu Glu Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  4

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Ala Ala Ala Asp 
            20                  25                  30          


Ala Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Glu Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Val Glu Ala Ala Glu Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  5
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  5

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Ala Ala Gln Ala 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Ala Ala Ala Gly Ala Leu Glu Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  6
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  6

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Ala Thr Ala Asp 
            20                  25                  30          


Ala Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Ala Glu Ala Ala Pro Leu Thr Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  7
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  7

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Ala Ala Pro 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Ala Glu Pro Gly Glu Leu Thr Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ser Tyr Ser Met 
1               5                   10                  15      


Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln Asp 
            20                  25                  30          


Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys 
        35                  40                  45              


Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly 
    50                  55                  60                  


Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val 
65                  70                  75                  80  


Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly 
                85                  90                  95      


Ala Glu Pro Ala Ala Leu Glu Leu Asn Trp Phe Lys Lys Gly Ser Ser 
            100                 105                 110         


Ile Gly Gln His His His His His His His His 
        115                 120             


<210>  9
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  9
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgcctcgacg tcgcacggta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgt tgagtctagt      300

cagctgagcc tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  10
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  10
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgagtcg tcgagcggta ccattgtgat ccgtgtgcag      120

tatgaaggct acggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgt tgagtctgct      300

cagctgaaac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  11
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  11
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgcagct gcagctggta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgt tgcaccaggt      300

caactggaac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  12
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  12
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgcagct gcagatgcta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcgaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgt tgaagcagct      300

gaactgaaac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  13
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  13
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgcagct caagctggta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgc tgcagcaggt      300

gcactggaac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  14
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  14
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgcaact gcagatgcta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgc tgaagcagct      300

ccactgacac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  15
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  15
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgaagct gcacctggta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgc tgaaccaggt      300

gaactgacac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  16
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  16
gactacaagg atgatgacga caaaggcagc ggcatgagct atagcatgtg caccggcaaa       60

tttaaaatcg tgaaagagat cgccgaaact caagatggta ccattgtgat ccgtgtgcag      120

tatgaaggcg atggtagccc gtgcaaaatc ccgttcgaga tcatggacct ggagaaacgc      180

catgtgctgg gtcgcctgat taccgtgaac ccgattgtga ccgagaaaga tagcccggtg      240

aacattgaag ccgaaccgcc gttcggcgat agctacatta tcattggtgc tgaaccagct      300

gcactggaac tgaactggtt caagaagggc agcagcattg gccagcatca tcatcatcat      360

catcatcatt aa                                                          372


<210>  17
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  17

Gly Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu 
1               5                   10                  15      


Val Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu 
            20                  25                  30          


Gly Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys 
        35                  40                  45              


Gly Val Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr 
    50                  55                  60                  


Asp Lys Glu Lys Pro Val Asn Ile Glu Thr Glu Pro Pro Phe Gly Glu 
65                  70                  75                  80  


Ser Tyr Ile Ile Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp 
                85                  90                  95      


Phe Lys Lys Gly Ser Ser Ile Gly Lys 
            100                 105 


<210>  18
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  18

Gly Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Ile Val Lys Glu 
1               5                   10                  15      


Ile Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu 
            20                  25                  30          


Gly Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu 
        35                  40                  45              


Lys Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr 
    50                  55                  60                  


Glu Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp 
65                  70                  75                  80  


Ser Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp 
                85                  90                  95      


Phe Lys Lys Gly Ser Ser Ile Gly Gln 
            100                 105 


<210>  19
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  19

Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe Val Leu Lys Lys Glu 
1               5                   10                  15      


Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys 
            20                  25                  30          


Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln 
        35                  40                  45              


Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr 
    50                  55                  60                  


Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu 
65                  70                  75                  80  


Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp 
                85                  90                  95      


Tyr Lys Lys Gly Ser Ser Ile Gly Lys 
            100                 105 


<210>  20
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue Virus Protein

<400>  20

Gly Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu 
1               5                   10                  15      


Met Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu 
            20                  25                  30          


Gly Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn 
        35                  40                  45              


Lys Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Phe Ala Glu 
    50                  55                  60                  


Asn Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp 
65                  70                  75                  80  


Ser Tyr Ile Val Ile Gly Val Gly Asp Ser Ala Leu Thr Leu His Trp 
                85                  90                  95      


Phe Arg Lys Gly Ser Ser Ile Gly Lys 
            100                 105 


