                         SEQUENCE LISTING

<110>  Inserm
 
<120>  POLYPEPTIDES FOR PREPARING DRUG CONJUGATES CAPABLE OF PROMOTING 
       APOPTOSIS IN A CELL EXPRESSING AN OREXIN RECEPTOR

<130>  BIO15429 ROBERT / MC

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  2
<211>  33
<212>  PRT
<213>  Gorilla

<400>  2

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  3
<211>  33
<212>  PRT
<213>  Orangutan

<400>  3

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  4
<211>  33
<212>  PRT
<213>  Chimpanzee

<400>  4

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  5
<211>  33
<212>  PRT
<213>  Gibbon

<400>  5

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  6
<211>  33
<212>  PRT
<213>  Green monkey

<400>  6

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  7
<211>  33
<212>  PRT
<213>  Macaque

<400>  7

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  8
<211>  33
<212>  PRT
<213>  Baboon

<400>  8

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  9
<211>  33
<212>  PRT
<213>  Cow

<400>  9

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  10
<211>  33
<212>  PRT
<213>  Rabbit

<400>  10

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  11
<211>  33
<212>  PRT
<213>  Pig

<400>  11

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  12
<211>  33
<212>  PRT
<213>  Dog

<400>  12

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  13
<211>  33
<212>  PRT
<213>  Bat

<400>  13

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  14
<211>  33
<212>  PRT
<213>  Yak

<400>  14

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  15
<211>  33
<212>  PRT
<213>  Horse

<400>  15

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  16
<211>  33
<212>  PRT
<213>  Squirrel

<400>  16

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  17
<211>  33
<212>  PRT
<213>  Tupai

<400>  17

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  18
<211>  33
<212>  PRT
<213>  Rat

<400>  18

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  19
<211>  33
<212>  PRT
<213>  Mouse

<400>  19

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  20
<211>  33
<212>  PRT
<213>  Otolemur

<400>  20

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  21
<211>  33
<212>  PRT
<213>  Guinea Pig

<400>  21

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  22
<211>  33
<212>  PRT
<213>  Polecat

<400>  22

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  23
<211>  33
<212>  PRT
<213>  Marmoset

<400>  23

Arg Leu Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Pro Cys Arg Arg 
1               5                   10                  15      


Tyr Glu Leu Leu His Arg Gly Gly Asn His Ala Gly Gly Leu Leu Val 
            20                  25                  30          


Leu 
    


<210>  24
<211>  33
<212>  PRT
<213>  Elephant

<400>  24

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  25
<211>  33
<212>  PRT
<213>  Oppossum

<400>  25

Gln Pro Met Pro Asn Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  26
<211>  33
<212>  PRT
<213>  Tasmanian devil

<400>  26

Gln Pro Met Pro Asn Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  27
<211>  33
<212>  PRT
<213>  Chinese hamster

<400>  27

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  28
<211>  33
<212>  PRT
<213>  Sheep

<400>  28

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  29
<211>  33
<212>  PRT
<213>  Chicken

<400>  29

Gln Ser Leu Pro Glu Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  30
<211>  33
<212>  PRT
<213>  Alligator

<400>  30

Gln Gly Val Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  31
<211>  33
<212>  PRT
<213>  Penguin

<400>  31

Gln Ser Leu Pro Glu Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  32
<211>  33
<212>  PRT
<213>  Amazon

<400>  32

Gln Ser Leu Pro Glu Cys Cys Arg Gln Lys Thr Cys Ser Cys His Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  33
<211>  33
<212>  PRT
<213>  Vulture

<400>  33

Gln Ser Leu Pro Glu Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  34
<211>  33
<212>  PRT
<213>  Flycatcher

<400>  34

Gln Asn Leu Pro His Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Val 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  35
<211>  33
<212>  PRT
<213>  Coelacanth

<400>  35

Gln Ser Val Pro Glu Cys Cys His Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asn Leu Leu His Gly Asn Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  36
<211>  33
<212>  PRT
<213>  Hummingbird

<400>  36

Gln Ser Leu Pro Glu Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Val 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  37
<211>  33
<212>  PRT
<213>  Manakin

<400>  37

Gln Ser Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Val 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  38
<211>  33
<212>  PRT
<213>  zebra finch

<400>  38

His Ser Leu Pro His Cys Cys Arg Gln Lys Thr Cys Pro Cys Arg Val 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  39
<211>  33
<212>  PRT
<213>  Grey

<400>  39

Gln Asn Leu Pro Glu Cys Cys Gln Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  40
<211>  33
<212>  PRT
<213>  Chinese softshell

<400>  40

Gln Ser Met Pro Val Cys Cys Arg Gln Lys Thr Cys Pro Cys Arg Val 
1               5                   10                  15      


Tyr Asp Val Leu His Gly Leu Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  41
<211>  33
<212>  PRT
<213>  Cobra

<400>  41

Arg Ala Val Pro Asp Cys Cys Arg Gln Lys Ser Cys Ser Cys Arg Ile 
1               5                   10                  15      


Phe Asp Leu Leu His Gly Met Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Ile 
    


<210>  42
<211>  33
<212>  PRT
<213>  Anole

<400>  42

Gln Ala Val Pro Asp Cys Cys Arg Gln Lys Ser Cys Pro Cys Asn Ile 
1               5                   10                  15      


Phe Asp Leu Leu His Gly Thr Gly Asn His Ala Asn Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  43
<211>  34
<212>  PRT
<213>  Ray

<400>  43

Ser Pro Arg Val Pro Lys Cys Cys Cys Gln Gln Thr Cys Ser Cys Lys 
1               5                   10                  15      


Val Ile Asp Leu Leu Arg Gly Thr Gly Asn His Ala Ala Gly Ile Leu 
            20                  25                  30          


Thr Leu 
        


<210>  44
<211>  36
<212>  PRT
<213>  Arowana

<400>  44

Ser Gln Val Arg His Cys Cys Arg Asp Gly Gly Asp Gly Thr Cys Pro 
1               5                   10                  15      


Cys Arg Leu Tyr Asp Val Leu Arg Gly Arg Gly Asp His Ala Ala Gly 
            20                  25                  30          


Ile Leu Thr Leu 
        35      


<210>  45
<211>  33
<212>  PRT
<213>  Xenopus

<400>  45

His Gly Ala Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Ile 
1               5                   10                  15      


Tyr Asp Ile Leu Arg Gly Thr Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  46
<211>  49
<212>  PRT
<213>  Zebra Fisch

<400>  46

Glu Gly Val Ala Ser Cys Cys Ala Arg Ala Pro Gly Ser Cys Lys Leu 
1               5                   10                  15      


Tyr Glu Met Leu Cys Arg Ala Gly Arg Arg Asn Asp Ser Ser Val Ala 
            20                  25                  30          


Arg His Leu Val His Leu Asn Asn Asp Ala Ala Val Gly Ile Leu Thr 
        35                  40                  45              


Leu 
    


<210>  47
<211>  49
<212>  PRT
<213>  Cod

<400>  47

Ser Val Ser Ala Ser Cys Cys Ser Arg Glu Pro Pro Arg Ala Cys Arg 
1               5                   10                  15      


Leu Tyr Val Leu Leu Leu Cys Gly Pro Val Gly Gly Ala Gly Arg Ala 
            20                  25                  30          


Leu Gly Gly Met His Leu Gly Glu Asp Ala Ser Ala Gly Ile Leu Thr 
        35                  40                  45              


Leu 
    


<210>  48
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  49
<211>  28
<212>  PRT
<213>  Gorilla

<400>  49

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  50
<211>  28
<212>  PRT
<213>  Orangutan

<400>  50

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  51
<211>  28
<212>  PRT
<213>  Chimpanzee

<400>  51

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  52
<211>  28
<212>  PRT
<213>  Gibbon

<400>  52

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  53
<211>  28
<212>  PRT
<213>  Green monkey

<400>  53

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  54
<211>  28
<212>  PRT
<213>  Macaque

<400>  54

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  55
<211>  28
<212>  PRT
<213>  Baboon

<400>  55

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  56
<211>  28
<212>  PRT
<213>  Cow

<400>  56

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  57
<211>  28
<212>  PRT
<213>  Rabbit

<400>  57

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  58
<211>  28
<212>  PRT
<213>  Pig

<400>  58

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  59
<211>  28
<212>  PRT
<213>  Dog

<400>  59

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  60
<211>  27
<212>  PRT
<213>  Bat

<400>  60

Arg Pro Gly Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln Ala 
1               5                   10                  15      


Asn Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25          


<210>  61
<211>  28
<212>  PRT
<213>  Yak

<400>  61

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  62
<211>  28
<212>  PRT
<213>  Horse

<400>  62

Arg Pro Gly Pro Pro Gly Leu His Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  63
<211>  28
<212>  PRT
<213>  Squirrel

<400>  63

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  64
<211>  28
<212>  PRT
<213>  Tupai

<400>  64

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  65
<211>  28
<212>  PRT
<213>  Rat

<400>  65

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Asn Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  66
<211>  28
<212>  PRT
<213>  Mouse

<400>  66

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Asn Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  67
<211>  28
<212>  PRT
<213>  Otolemur

<400>  67

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  68
<211>  28
<212>  PRT
<213>  Guinea Pig

<400>  68

Arg Pro Arg Pro Ala Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Leu 
1               5                   10                  15      


Ala Gly Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  69
<211>  28
<212>  PRT
<213>  Polecat

<400>  69

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  70
<211>  28
<212>  PRT
<213>  Marmoset

<400>  70

Arg Ala Gly Pro Pro Asn Leu Gln Gly Gln Leu Gln His Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Lys His Ala Thr Gly Ile Leu Thr Leu 
            20                  25              


<210>  71
<211>  28
<212>  PRT
<213>  Elephant

<400>  71

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  72
<211>  28
<212>  PRT
<213>  Oppossum

<400>  72

Arg Ala Gly Leu Ser Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Val 
            20                  25              


<210>  73
<211>  28
<212>  PRT
<213>  Tasmanian devil

<400>  73

Arg Ala Gly Leu Ser Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Val 
            20                  25              


<210>  74
<211>  28
<212>  PRT
<213>  Chinese hamster

<400>  74

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  75
<211>  28
<212>  PRT
<213>  Sheep

<400>  75

Arg Pro Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  76
<211>  28
<212>  PRT
<213>  Chicken

<400>  76

Lys Ser Ile Pro Pro Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  77
<211>  28
<212>  PRT
<213>  Alligator

<400>  77

Lys Ser Gly Ser Gln Pro Phe Gln Ser Arg Leu Tyr Arg Leu Leu Gln 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  78
<211>  28
<212>  PRT
<213>  Penguin

<400>  78

Lys Ser Val Pro Pro Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Ser Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  79
<211>  28
<212>  PRT
<213>  Amazon

<400>  79

Lys Ser Val Pro Pro Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Ser Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  80
<211>  28
<212>  PRT
<213>  Vulture

<400>  80

Lys Ser Ile Pro Pro Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  81
<211>  28
<212>  PRT
<213>  Flycatcher

<400>  81

Lys Ser Val Pro Leu Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  82
<211>  29
<212>  PRT
<213>  Coelacanth

<400>  82

Lys Glu Ala Pro Pro His Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu 
1               5                   10                  15      


His Ser Pro Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25                  


<210>  83
<211>  28
<212>  PRT
<213>  Hummingbird

<400>  83

Lys Ser Ile Pro Ser Ala Phe Gln Ser Arg Leu Tyr His Leu Leu His 
1               5                   10                  15      


Ser Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  84
<211>  28
<212>  PRT
<213>  Manakin

<400>  84

Lys Ser Val Pro Leu Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  85
<211>  28
<212>  PRT
<213>  Zebra Finch

<400>  85

Lys Ser Val Pro Leu Thr Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  86
<211>  28
<212>  PRT
<213>  Grey

<400>  86

Lys Ser Val Leu Pro Ala Phe Gln Ser Arg Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Ser Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  87
<211>  28
<212>  PRT
<213>  Chinese softshell

<400>  87

Arg Ser Ser Ser Gln Ala Phe Gln Ser Gln Leu Tyr Arg Leu Leu His 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  88
<211>  30
<212>  PRT
<213>  Cobra

<400>  88

Ser Ser Ala Met Thr Thr Lys Gly Phe Gln Ser Arg Leu Tyr Arg Leu 
1               5                   10                  15      


Leu His Gly Ser Glu Asn Gln Ala Ala Gly Ile Leu Thr Met 
            20                  25                  30  


<210>  89
<211>  30
<212>  PRT
<213>  Anole

<400>  89

Gly Ser Ala Thr Ala Thr Lys Thr Phe Gln Ser Arg Leu Tyr Arg Leu 
1               5                   10                  15      


Phe His Ser Ser Asp Asn Gln Ala Ala Gly Ile Leu Thr Met 
            20                  25                  30  


<210>  90
<211>  28
<212>  PRT
<213>  Ray

<400>  90

Lys Thr Asn Ala Gln Pro Leu Gln Asn Arg Leu His His Leu Leu His 
1               5                   10                  15      


Gly Leu Glu Asn Gln Ala Thr Gly Ile Leu Thr Met 
            20                  25              


<210>  91
<211>  28
<212>  PRT
<213>  Arowana

<400>  91

Gln Lys Pro Glu Arg His Val Gln Ser Arg Leu Tyr Gln Leu Leu Gln 
1               5                   10                  15      


Gly Ser Arg Asp His Thr Ala Gly Ile Leu Thr Tyr 
            20                  25              


<210>  92
<211>  28
<212>  PRT
<213>  Xenopus

<400>  92

Ser Asp Phe Gln Thr Met Gln Ser Arg Leu Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Gly Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  93
<211>  28
<212>  PRT
<213>  Zebra Fisch

<400>  93

Lys Val Gly Glu Ser Arg Val His Asp Arg Leu Gln Gln Leu Leu His 
1               5                   10                  15      


Asn Ser Arg Asn Gln Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  94
<211>  29
<212>  PRT
<213>  Cod

<400>  94

Glu Ala Glu Glu Gln His Phe His Ser Arg Leu His Gln Leu Leu Arg 
1               5                   10                  15      


Gly Gly Ala Arg Asn Gln Ala Ala Gly Ile Leu Thr Met 
            20                  25                  


<210>  95
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr 
1               5                   10      


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met Gly Arg Arg 
1               5                   10                  15  


<210>  97
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  97

Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln Ala Ser Gly Asn His 
1               5                   10                  15      


Ala Ala Gly Ile Leu Thr 
            20          


<210>  98
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  98

Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln Ala Ser Gly Asn His 
1               5                   10                  15      


Ala Ala Gly Ile Leu Thr Gly Arg Arg 
            20                  25  


<210>  99
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  99

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met 
            20                  25              


<210>  100
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  100

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met Gly 
            20                  25                  


<210>  101
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  101

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met Gly Arg 
            20                  25                  30  


<210>  102
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  102

Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln 
1               5                   10                  15      


Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met Gly Arg Arg 
            20                  25                  30      


<210>  103
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr Leu 
1               5                   10          


<210>  104
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr Leu Gly 
1               5                   10              


<210>  105
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH cetuximab

<400>  105

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  106
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL cetuximab

<400>  106

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  107

Asn His Ala Ala Gly Ile Leu Thr Met Gly Arg Arg 
1               5                   10          


