                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum Stiftung des ffentlichen 
       Rechts
 
<120>  MODULATORS OF CCR9 FOR TREATING TUMOR RESISTANCE TO IMMUNE 
       RESPONSES

<130>  D31465WO

<150>  US62295560
<151>  2016-02-16

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  2
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile 
    210                 215                 220                 


Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  3
<211>  2567
<212>  DNA
<213>  Homo sapiens

<400>  3
gcttcctttc tcgtgttgtt atcgggtagc tgcctgctca gaacccacaa agcctgcccc       60

tcatcccagg cagagagcaa cccagctctt tccccagaca ctgagagctg gtggtgcctg      120

ctgtcccagg gagagttgca tcgccctcca cagagcaggc ttgcatctga ctgacccacc      180

atgacaccca cagacttcac aagccctatt cctaacatgg ctgatgacta tggctctgaa      240

tccacatctt ccatggaaga ctacgttaac ttcaacttca ctgacttcta ctgtgagaaa      300

aacaatgtca ggcagtttgc gagccatttc ctcccaccct tgtactggct cgtgttcatc      360

gtgggtgcct tgggcaacag tcttgttatc cttgtctact ggtactgcac aagagtgaag      420

accatgaccg acatgttcct tttgaatttg gcaattgctg acctcctctt tcttgtcact      480

cttcccttct gggccattgc tgctgctgac cagtggaagt tccagacctt catgtgcaag      540

gtggtcaaca gcatgtacaa gatgaacttc tacagctgtg tgttgctgat catgtgcatc      600

agcgtggaca ggtacattgc cattgcccag gccatgagag cacatacttg gagggagaaa      660

aggcttttgt acagcaaaat ggtttgcttt accatctggg tattggcagc tgctctctgc      720

atcccagaaa tcttatacag ccaaatcaag gaggaatccg gcattgctat ctgcaccatg      780

gtttacccta gcgatgagag caccaaactg aagtcagctg tcttgaccct gaaggtcatt      840

ctggggttct tccttccctt cgtggtcatg gcttgctgct ataccatcat cattcacacc      900

ctgatacaag ccaagaagtc ttccaagcac aaagccctaa aagtgaccat cactgtcctg      960

accgtctttg tcttgtctca gtttccctac aactgcattt tgttggtgca gaccattgac     1020

gcctatgcca tgttcatctc caactgtgcc gtttccacca acattgacat ctgcttccag     1080

gtcacccaga ccatcgcctt cttccacagt tgcctgaacc ctgttctcta tgtttttgtg     1140

ggtgagagat tccgccggga tctcgtgaaa accctgaaga acttgggttg catcagccag     1200

gcccagtggg tttcatttac aaggagagag ggaagcttga agctgtcgtc tatgttgctg     1260

gagacaacct caggagcact ctccctctga ggggtcttct ctgaggtgca tggttctttt     1320

ggaagaaatg agaaatacag aaacagtttc cccactgatg ggaccagaga gagtgaaaga     1380

gaaaagaaaa ctcagaaagg gatgaatctg aactatatga ttacttgtag tcagaatttg     1440

ccaaagcaaa tatttcaaaa tcaactgact agtgcaggag gctgttgatt ggctcttgac     1500

tgtgatgccc gcaattctca aaggaggact aaggaccggc actgtggagc accctggctt     1560

tgccactcgc cggagcatca atgccgctgc ctctggagga gcccttggat tttctccatg     1620

cactgtgaac ttctgtggct tcagttctca tgctgcctct tccaaaaggg gacacagaag     1680

cactggctgc tgctacagac cgcaaaagca gaaagtttcg tgaaaatgtc catctttggg     1740

aaattttcta ccctgctctt gagcctgata acccatgcca ggtcttatag attcctgatc     1800

tagaaccttt ccaggcaatc tcagacctaa tttccttctg ttctccttgt tctgttctgg     1860

gccagtgaag gtccttgttc tgattttgaa acgatctgca ggtcttgcca gtgaacccct     1920

ggacaactga ccacacccac aaggcatcca aagtctgttg gcttccaatc catttctgtg     1980

tcctgctgga ggttttaacc tagacaagga ttccgcttat tccttggtat ggtgacagtg     2040

tctctccatg gcctgagcag ggagattata acagctgggt tcgcaggagc cagccttggc     2100

cctgttgtag gcttgttctg ttgagtggca cttgctttgg gtccaccgtc tgtctgctcc     2160

ctagaaaatg ggctggttct tttggccctc ttctttctga ggcccacttt attctgagga     2220

atacagtgag cagatatggg cagcagccag gtagggcaaa ggggtgaagc gcaggccttg     2280

ctggaaggct atttacttcc atgcttctcc ttttcttact ctatagtggc aacattttaa     2340

aagcttttaa cttagagatt aggctgaaaa aaataagtaa tggaattcac ctttgcatct     2400

tttgtgtctt tcttatcatg atttggcaaa atgcatcacc tttgaaaata tttcacatat     2460

tggaaaagtg ctttttaatg tgtatatgaa gcattaatta cttgtcactt tctttaccct     2520

gtctcaatat tttaagtgtg tgcaattaaa gatcaaatag atacatt                   2567


<210>  4
<211>  2518
<212>  DNA
<213>  Homo sapiens

<400>  4
gcttcctttc tcgtgttgtt atcgggtagc tgcctgctca gaacccacaa agcctgcccc       60

tcatcccagg cagagagcaa cccagctctt tccccagaca ctgagagctg gtggtgcctg      120

ctgtcccagg gagagttgca tcgccctcca caagccctat tcctaacatg gctgatgact      180

atggctctga atccacatct tccatggaag actacgttaa cttcaacttc actgacttct      240

actgtgagaa aaacaatgtc aggcagtttg cgagccattt cctcccaccc ttgtactggc      300

tcgtgttcat cgtgggtgcc ttgggcaaca gtcttgttat ccttgtctac tggtactgca      360

caagagtgaa gaccatgacc gacatgttcc ttttgaattt ggcaattgct gacctcctct      420

ttcttgtcac tcttcccttc tgggccattg ctgctgctga ccagtggaag ttccagacct      480

tcatgtgcaa ggtggtcaac agcatgtaca agatgaactt ctacagctgt gtgttgctga      540

tcatgtgcat cagcgtggac aggtacattg ccattgccca ggccatgaga gcacatactt      600

ggagggagaa aaggcttttg tacagcaaaa tggtttgctt taccatctgg gtattggcag      660

ctgctctctg catcccagaa atcttataca gccaaatcaa ggaggaatcc ggcattgcta      720

tctgcaccat ggtttaccct agcgatgaga gcaccaaact gaagtcagct gtcttgaccc      780

tgaaggtcat tctggggttc ttccttccct tcgtggtcat ggcttgctgc tataccatca      840

tcattcacac cctgatacaa gccaagaagt cttccaagca caaagcccta aaagtgacca      900

tcactgtcct gaccgtcttt gtcttgtctc agtttcccta caactgcatt ttgttggtgc      960

agaccattga cgcctatgcc atgttcatct ccaactgtgc cgtttccacc aacattgaca     1020

tctgcttcca ggtcacccag accatcgcct tcttccacag ttgcctgaac cctgttctct     1080

atgtttttgt gggtgagaga ttccgccggg atctcgtgaa aaccctgaag aacttgggtt     1140

gcatcagcca ggcccagtgg gtttcattta caaggagaga gggaagcttg aagctgtcgt     1200

ctatgttgct ggagacaacc tcaggagcac tctccctctg aggggtcttc tctgaggtgc     1260

atggttcttt tggaagaaat gagaaataca gaaacagttt ccccactgat gggaccagag     1320

agagtgaaag agaaaagaaa actcagaaag ggatgaatct gaactatatg attacttgta     1380

gtcagaattt gccaaagcaa atatttcaaa atcaactgac tagtgcagga ggctgttgat     1440

tggctcttga ctgtgatgcc cgcaattctc aaaggaggac taaggaccgg cactgtggag     1500

caccctggct ttgccactcg ccggagcatc aatgccgctg cctctggagg agcccttgga     1560

ttttctccat gcactgtgaa cttctgtggc ttcagttctc atgctgcctc ttccaaaagg     1620

ggacacagaa gcactggctg ctgctacaga ccgcaaaagc agaaagtttc gtgaaaatgt     1680

ccatctttgg gaaattttct accctgctct tgagcctgat aacccatgcc aggtcttata     1740

gattcctgat ctagaacctt tccaggcaat ctcagaccta atttccttct gttctccttg     1800

ttctgttctg ggccagtgaa ggtccttgtt ctgattttga aacgatctgc aggtcttgcc     1860

agtgaacccc tggacaactg accacaccca caaggcatcc aaagtctgtt ggcttccaat     1920

ccatttctgt gtcctgctgg aggttttaac ctagacaagg attccgctta ttccttggta     1980

tggtgacagt gtctctccat ggcctgagca gggagattat aacagctggg ttcgcaggag     2040

ccagccttgg ccctgttgta ggcttgttct gttgagtggc acttgctttg ggtccaccgt     2100

ctgtctgctc cctagaaaat gggctggttc ttttggccct cttctttctg aggcccactt     2160

tattctgagg aatacagtga gcagatatgg gcagcagcca ggtagggcaa aggggtgaag     2220

cgcaggcctt gctggaaggc tatttacttc catgcttctc cttttcttac tctatagtgg     2280

caacatttta aaagctttta acttagagat taggctgaaa aaaataagta atggaattca     2340

cctttgcatc ttttgtgtct ttcttatcat gatttggcaa aatgcatcac ctttgaaaat     2400

atttcacata ttggaaaagt gctttttaat gtgtatatga agcattaatt acttgtcact     2460

ttctttaccc tgtctcaata ttttaagtgt gtgcaattaa agatcaaata gatacatt       2518


<210>  5
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  CCR9-specific shRNA hairpin

<400>  5
accgggccag tggaggtctt tgttctgtta atattcatag cagaacaagg accttcactg       60

gctttt                                                                  66


