                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR NEURALGENESIS

<130> 48317-518001WO

<140> PCT/US2017/017464
<141> 2017-02-10

<150> 62/294,112
<151> 2016-02-11

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 938
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
    850                 855                 860                 


Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
865                 870                 875                 880 


Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                885                 890                 895     


Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
            900                 905                 910         


Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
        915                 920                 925             


Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
    930                 935             


<210> 2
<211> 4400
<212> DNA
<213> Homo sapiens

<400> 2
gtcgccgcag cgtccggacc ggaaccagcg ccgtccgcgg agccgccgcc gccgccgccg       60

ggccctttcc aagccgggcg ctcggagctg tgcccggccc cgcttcagca ccgcggacag      120

cgccggccgc gtggggctga gccccgagcc cccgcgcacg cttcagcgcc ccttccctcg      180

gccgacgtcc cgggaccgcc gctccggggg agacgtggcg tccgcagccc gcggggccgg      240

gcgagcgcag gacggcccgg aagccccgcg ggggatgcgc cgagggcccc gcgttcgcgc      300

cgcgcagagc caggcccgcg gcccgagccc atgagcacca tgcgcctgct gacgctcgcc      360

ctgctgttct cctgctccgt cgcccgtgcc gcgtgcgacc ccaagatcgt caacattggc      420

gcggtgctga gcacgcggaa gcacgagcag atgttccgcg aggccgtgaa ccaggccaac      480

aagcggcacg gctcctggaa gattcagctc aatgccacct ccgtcacgca caagcccaac      540

gccatccaga tggctctgtc ggtgtgcgag gacctcatct ccagccaggt ctacgccatc      600

ctagttagcc atccacctac ccccaacgac cacttcactc ccacccctgt ctcctacaca      660

gccggcttct accgcatacc cgtgctgggg ctgaccaccc gcatgtccat ctactcggac      720

aagagcatcc acctgagctt cctgcgcacc gtgccgccct actcccacca gtccagcgtg      780

tggtttgaga tgatgcgtgt ctacagctgg aaccacatca tcctgctggt cagcgacgac      840

cacgagggcc gggcggctca gaaacgcctg gagacgctgc tggaggagcg tgagtccaag      900

gcagagaagg tgctgcagtt tgacccaggg accaagaacg tgacggccct gctgatggag      960

gcgaaagagc tggaggcccg ggtcatcatc ctttctgcca gcgaggacga tgctgccact     1020

gtataccgcg cagccgcgat gctgaacatg acgggctccg ggtacgtgtg gctggtcggc     1080

gagcgcgaga tctcggggaa cgccctgcgc tacgccccag acggcatcct cgggctgcag     1140

ctcatcaacg gcaagaacga gtcggcccac atcagcgacg ccgtgggcgt ggtggcccag     1200

gccgtgcacg agctcctcga gaaggagaac atcaccgacc cgccgcgggg ctgcgtgggc     1260

aacaccaaca tctggaagac cgggccgctc ttcaagagag tgctgatgtc ttccaagtat     1320

gcggatgggg tgactggtcg cgtggagttc aatgaggatg gggaccggaa gttcgccaac     1380

tacagcatca tgaacctgca gaaccgcaag ctggtgcaag tgggcatcta caatggcacc     1440

cacgtcatcc ctaatgacag gaagatcatc tggccaggcg gagagacaga gaagcctcga     1500

gggtaccaga tgtccaccag actgaagatt gtgacgatcc accaggagcc cttcgtgtac     1560

gtcaagccca cgctgagtga tgggacatgc aaggaggagt tcacagtcaa cggcgaccca     1620

gtcaagaagg tgatctgcac cgggcccaac gacacgtcgc cgggcagccc ccgccacacg     1680

gtgcctcagt gttgctacgg cttttgcatc gacctgctca tcaagctggc acggaccatg     1740

aacttcacct acgaggtgca cctggtggca gatggcaagt tcggcacaca ggagcgggtg     1800

aacaacagca acaagaagga gtggaatggg atgatgggcg agctgctcag cgggcaggca     1860

gacatgatcg tggcgccgct aaccataaac aacgagcgcg cgcagtacat cgagttttcc     1920

aagcccttca agtaccaggg cctgactatt ctggtcaaga aggagattcc ccggagcacg     1980

ctggactcgt tcatgcagcc gttccagagc acactgtggc tgctggtggg gctgtcggtg     2040

cacgtggtgg ccgtgatgct gtacctgctg gaccgcttca gccccttcgg ccggttcaag     2100

gtgaacagcg aggaggagga ggaggacgca ctgaccctgt cctcggccat gtggttctcc     2160

tggggcgtcc tgctcaactc cggcatcggg gaaggcgccc ccagaagctt ctcagcgcgc     2220

atcctgggca tggtgtgggc cggctttgcc atgatcatcg tggcctccta caccgccaac     2280

ctggcggcct tcctggtgct ggaccggccg gaggagcgca tcacgggcat caacgaccct     2340

cggctgagga acccctcgga caagtttatc tacgccacgg tgaagcagag ctccgtggat     2400

atctacttcc ggcgccaggt ggagctgagc accatgtacc ggcatatgga gaagcacaac     2460

tacgagagtg cggcggaggc catccaggcc gtgagagaca acaagctgca tgccttcatc     2520

tgggactcgg cggtgctgga gttcgaggcc tcgcagaagt gcgacctggt gacgactgga     2580

gagctgtttt tccgctcggg cttcggcata ggcatgcgca aagacagccc ctggaagcag     2640

aacgtctccc tgtccatcct caagtcccac gagaatggct tcatggaaga cctggacaag     2700

acgtgggttc ggtatcagga atgtgactcg cgcagcaacg cccctgcgac ccttactttt     2760

gagaacatgg ccggggtctt catgctggta gctgggggca tcgtggccgg gatcttcctg     2820

attttcatcg agattgccta caagcggcac aaggatgctc gccggaagca gatgcagctg     2880

gcctttgccg ccgttaacgt gtggcggaag aacctgcagg atagaaagag tggtagagca     2940

gagcctgacc ctaaaaagaa agccacattt agggctatca cctccaccct ggcttccagc     3000

ttcaagaggc gtaggtcctc caaagacacg agcaccgggg gtggacgcgg cgctttgcaa     3060

aaccaaaaag acacagtgct gccgcgacgc gctattgaga gggaggaggg ccagctgcag     3120

ctgtgttccc gtcataggga gagctgagac tccccgcccg ccctcctctg ccccctcccc     3180

cgcagacaga cagacagacg gacgggacag cggcccggcc cacgcagagc cccggagcac     3240

cacggggtcg ggggaggagc acccccagcc tcccccaggc tgcgcctgcc cgcccgccgg     3300

ttggccggct ggccggtcca ccccgtcccg gccccgcgcg tgcccccagc gtggggctaa     3360

cgggcgcctt gtctgtgtat ttctattttg cagcagtacc atcccactga tatcacgggc     3420

ccgctcaacc tctcagatcc ctcggtcagc accgtggtgt gaggcccccg gaggcgccca     3480

cctgcccagt tagcccggcc aaggacactg atgggtcctg ctgctcggga aggcctgagg     3540

gaagcccacc cgccccagag actgcccacc ctgggcctcc cgtccgtccg cccgcccacc     3600

ccgctgcctg gcgggcagcc cctgctggac caaggtgcgg accggagcgg ctgaggacgg     3660

ggcagagctg agtcggctgg gcagggccgc agggcgctcc ggcagaggca gggccctggg     3720

gtctctgagc agtggggagc gggggctaac tggccccagg cggaggggct tggagcagag     3780

acggcagccc catccttccc gcagcaccag cctgagccac agtggggccc atggccccag     3840

ctggctgggt cgcccctcct cgggcgcctg cgctcctctg cagcctgagc tccaccctcc     3900

cctcttcttg cggcaccgcc cacccacacc ccgtctgccc cttgacccca cacgccgggg     3960

ctggccctgc cctcccccac ggccgtccct gacttcccag ctggcagcgc ctcccgccgc     4020

ctcgggccgc ctcctccaga ctcgagaggg ctgagcccct cctctcctcg tccggcctgc     4080

agcccagaac gggcctcccc gggggtcccc ggacgctggc tcgggactgt cttcaaccct     4140

gccctgcacc ttgggcacgg gagagcgcca cccgcccgcc cccgccctcg ctccgggtgc     4200

gtgaccggcc cgccaccttg tacagaacca gcactcccag ggcccgagcg cgtgccttcc     4260

ccgtgcggcc cgtgcgcagc cgcgctctgc ccctccgtcc ccagggtgca ggcgcgcacc     4320

gcccaacccc cacctcccgg tgtatgcagt ggtgatgcct aaaggaatgt cacgcagttt     4380

tcaaaaaaaa aaaaaaaaaa                                                 4400


<210> 3
<211> 594
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210> 4
<211> 4007
<212> DNA
<213> Homo sapiens

<400> 4
agcgtgtggt agaggagaaa cgctgaaacc ggaccgaaac ctcgccctag gcttagcgat       60

ggctaaaaac cggctgggac aagagggagg caagcaacat tccgactcgc tgctttctgg      120

ctgtctggag tgcaaggtga ctgtggttct tctctggcca agtccgaggg agaacgtaaa      180

gatatgggcc tttttccccc tctcaccttg tctcaccaaa gtccctagtc cccggagcag      240

ttagcctctt tctttccagg gaattagcca gacacaacaa cgggaaccag acaccgaacc      300

agacatgccc gccccgtgcg ccctcccccc gctggcccac acgccggctg ctgagtgccc      360

aatggggctt gtagcggctc ggctggaaaa tcgctcactg agcgctcccc tgtgctccta      420

gcccagtccc ccacaccctt gcgtcttgta ctggccttgg acccccaccc cgaccccgac      480

cccgcctcgt ctcggcgctt cactccaggt cgcgccgatg caccgccaga ctcgagagcg      540

gcccagggct acgctccctg cgccccagta ccggagctag cgcgcacgtc tcctccgctg      600

cccccacccc tgcgcacccc taccaggcag gctcgctgcc tttcctccct cttgtctctc      660

cagagccgga tcttcaaggg gagcctccgt gcccccggct gctcagtccc tccggtgtgc      720

aggaccccgg aagtcctccc cgcacagctc tcgcttctct ttgcagcctg tttctgcgcc      780

ggaccagtcg aggactctgg acagtagagg ccccgggacg accgagctga tggcgtcttc      840

gaccccatct tcgtccgcaa cctcctcgaa cgcgggagcg gaccccaata ccactaacct      900

gcgccccaca acgtacgata cctggtgcgg cgtggcccat ggatgcacca gaaaactggg      960

gctcaagatc tgcggcttct tgcaaaggac caacagcctg gaagagaaga gtcgccttgt     1020

gagtgccttc aaggagaggc aatcctccaa gaacctgctt tcctgtgaaa acagcgaccg     1080

ggatgcccgc ttccggcgca cagagactga cttctctaat ctgtttgcta gagatctgct     1140

tccggctaag aacggtgagg agcaaaccgt gcaattcctc ctggaagtgg tggacatact     1200

cctcaactat gtccgcaaga catttgatcg ctccaccaag gtgctggact ttcatcaccc     1260

acaccagttg ctggaaggca tggagggctt caacttggag ctctctgacc accccgagtc     1320

cctggagcag atcctggttg actgcagaga caccttgaag tatggggttc gcacaggtca     1380

tcctcgattt ttcaaccagc tctccactgg attggatatt attggcctag ctggagaatg     1440

gctgacatca acggccaata ccaacatgtt tacatatgaa attgcaccag tgtttgtcct     1500

catggaacaa ataacactta agaagatgag agagatagtt ggatggtcaa gtaaagatgg     1560

tgatgggata ttttctcctg ggggcgccat atccaacatg tacagcatca tggctgctcg     1620

ctacaagtac ttcccggaag ttaagacaaa gggcatggcg gctgtgccta aactggtcct     1680

cttcacctca gaacagagtc actattccat aaagaaagct ggggctgcac ttggctttgg     1740

aactgacaat gtgattttga taaagtgcaa tgaaaggggg aaaataattc cagctgattt     1800

tgaggcaaaa attcttgaag ccaaacagaa gggatatgtt cccttttatg tcaatgcaac     1860

tgctggcacg actgtttatg gagcttttga tccgatacaa gagattgcag atatatgtga     1920

gaaatataac ctttggttgc atgtcgatgg atttaacttc tcacaattgg ccaataggat     1980

catctgcctt gctactgaac taatgactaa caaaggctgt gtcacgtggc atcccaacta     2040

ttcagtaaac atgcatcatg gctgcctggg gaggtgggct gctcatgtcc aggaagcacc     2100

accataaact caacggcata gaaagggcca actcagtcac ctggaaccct cacaagatga     2160

tgggcgtgct gttgcagtgc tctgccattc tcgtcaagga aaagggtata ctccaaggat     2220

gcaaccagat gtgtgcagga tacctcttcc agccagacaa gcagtatgat gtctcctacg     2280

acaccgggga caaggcaatt cagtgtggcc gccacgtgga tatcttcaag ttctggctga     2340

tgtggaaagc aaagggcaca gtgggatttg aaaaccagat caacaaatgc ctggaactgg     2400

ctgaatacct ctatgccaag attaaaaaca gagaagaatt tgagatggtt ttcaatggcg     2460

agcctgagca cacaaacgtc tgtttttggt atattccaca aagcctcagg ggtgtgccag     2520

acagccctca acgacgggaa aagctacaca aggtggctcc aaaaatcaaa gccctgatga     2580

tggagtcagg tacgaccatg gttggctacc agccccaagg ggacaaggcc aacttcttcc     2640

ggatggtcat ctccaaccca gccgctaccc agtctgacat tgacttcctc attgaggaga     2700

tagaaagact gggccaggat ctgtaatcat ccttcgcaga acatgagttt atgggaatgc     2760

cttttccctc tggcactcca gaacaaacct ctatatgttg ctgaaacaca caggccattt     2820

cattgaggga aaacataata tcttgaagaa tattgttaaa accttactta aagcttgttt     2880

gttctagtta gcaggaaata gtgttctttt taaaaagttg cacattagga acagagtata     2940

tatgtacagt tatacatacc tctctctata tatacatgta tagtgagtgt ggcttagtaa     3000

tagatcacgg catgtttccc gctccaagag aattcacttt accttcagca gttaccgagg     3060

agctaaacat gctgccaacc agcttgtcca acaactccag gaaaactgtt tttcaaaacg     3120

ccatgtccta ggggccaagg gaaatgctgt tggtgagaat cgacctcact gtcagcgttt     3180

ctccacctga agtgatgatg gatgagaaaa aacaccacca aatgacaagt cacaccctcc     3240

ccattagtat cctgttaggg gaaaatagta gcagagtcat tgttacaggt gtactatggc     3300

tgtattttta gagattaatt tgtgtagatt gtgtaaattc ctgttgtctg accttggtgg     3360

tgggaggggg agactatgtg tcatgatttc aatgattgtt taattgtagg tcaatgaaat     3420

atttgcttat ttatattcag agatgtacca tgttaaagag gcgtcttgta ttttcttccc     3480

atttgtaatg tatcttattt atatatgaag taagttctga aaactgttta tggtattttc     3540

gtgcatttgt gagccaaaga gaaaagatta aaattagtga gatttgtatt tatattagag     3600

tgcccttaaa ataatgattt aagcatttta ctgtctgtaa gagaattcta agattgtaca     3660

taaagtcata tatatggaaa tcctgttact taaatagcat ctgctcttct cttacgctct     3720

ctgtctggct gtacgtctgg tgttctcaat gcttttctag caactgttgg ataataacta     3780

gatctcctgt aattttgtag tagttgatga ccaatctctg ttactcgctt agctgaaacc     3840

taaggcaaca tttccgaaga ccttctgaag atctcagata aagtgaccag gctcacaact     3900

gtttttgaag aagggaaatt cacactgtgc gttttagagt atgcaagaag aatataaata     3960

aataaaaata ttctccatgg agaatttgaa caaaaaaaaa aaaaaaa                   4007


<210> 5
<211> 599
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210> 6
<211> 1981
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (68)..(68)
<223> a, c, t, g, unknown or other

<400> 6
gtagcttcac taaggtggga tggatagcag ggtctcaggc acaaccagta atggagagac       60

aaaaccantg tatcacaaga tggagtttgt gctgtcagtg gctggggaga tcattggctt      120

aggcaacgtc tggaggtttc cctatctctg ctacaaaaat gggggaggtg ccttcttcat      180

cccctacctc gtcttcctct ttacctgtgg cattcctgtc ttccttctgg agacagcact      240

aggccagtac actagccagg gaggcgtcac agcctggagg aagatctgcc ccatctttga      300

gggcattggc tatgcctccc agatgatcgt catcctcctc aacgtctact acatcattgt      360

gttggcctgg gccctgttct acctcttcag cagcttcacc atcgacctgc cctggggcgg      420

ctgctaccat gagtggaaca cagaacactg tatggagttc cagaagacca acggctccct      480

gaatggtacc tctgagaatg ccacctctcc tgtcatcgag ttctgggagc ggcgggtctt      540

gaagatctct gatgggatcc agcacctggg ggccctgcgc tgggagctgg ctctgtgcct      600

cctgctggcc tgggtcatct gctacttctg catctggaag ggggtgaagt ccacaggcaa      660

ggtggtgtac ttcacggcca catttcctta cctcatgctg gtggtcctgt taattcgagg      720

ggtgacgttg cctggggcag cccaaggaat tcagttttac ctgtacccaa acctcacgcg      780

tctgtgggat ccccaggtgt ggatggatgc aggcacccag atattcttct ccttcgccat      840

ctgtcttggg tgcctgacag ccctgggcag ctacaacaag taccacaaca actgctacag      900

cggcaccagc tttgtggccg gctttgccat cttctccatc ctgggcttca tgtctcagga      960

gcagggggtg cccatttctg aggtggccga gtcaggccct ggcctggctt tcatcgctta     1020

cccgcgggct gtggtgatgc tgcccttctc tcctctctgg gcctgctgtt tcttcttcat     1080

ggtcgttctc ctgggactgg atagccagtt tgtgtgtgta gaaagcctgg tgacagcgct     1140

ggtggacatg taccctcacg tgttccgcaa gaagaaccgg agggaagtcc tcatccttgg     1200

agtatctgtc gtctccttcc ctgtggggct gatcatgctc acagagggcg gaatgtacgt     1260

gttccagctc tttgactact atgcggccag tggcatgtgc ctcctgttcg tggccatctt     1320

cgagtccctc tgtgtggctt gggtttacgg agccaagcgc ttctacgaca acatcgaaga     1380

catgattggg tacaggccat ggcctcttat caaatactgt tggctcttcc tcacaccagc     1440

tgtgtgcaca gccacctttc tcttctccct gataaagtac actccgctga cctacaacaa     1500

gaagtacacg tacccgtggt ggggcgatgc cctgggctgg ctcctggctc tgtcctcctg     1560

gtctgcattc ctgcctggag cctctacaga ctcggaaccc tcaagggccc cttcagagag     1620

agaatccgtc agctcatgtg cccagccgag gacctgcccc agcggaaccc agcaggaccc     1680

tcggctcccg ccacccccag gacctcactg ctcagactca cagagctaga gtctcactgc     1740

tagggggcag gcccttggat ggtgcctgtg tgcctggcct tggggatggc tgtggaggga     1800

acgtggcaga agcagcccca tgtgttccct gcccccgacc tggagtggat aagacaagag     1860

gggtattttg gagtccacct gctgagctgg aggcctccca ctgcaacttt tcagctcagg     1920

ggttgttgaa cagatgtgaa aaggccagtg ccaagagtgt ccctcggaga cccttgaagg     1980

c                                                                     1981


<210> 7
<211> 528
<212> PRT
<213> Homo sapiens

<400> 7
Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210> 8
<211> 14877
<212> DNA
<213> Homo sapiens

<400> 8
gcgggggggc agtgtgtgct ccagcatgtg tgtgtgtgtg tgcatgtaca cgtgtgcacc       60

tgtatcgcct gtgtgtgtgc atgtgatgtg tacacgtgtc atgcatgcac gcacatgtgt      120

agtgtgtgct cgtgtgtggt gtgtgcctgt gtcatgtatg agcacacttg tatatgttgt      180

gtgtactgtg tcatatatga gtgtgtttgc ctgtgtagtg catgcacatc cgtgtgtgca      240

tctggtgtgt ccgtgggtca ttacgagtgc atcgtatgtg tatcgtgtac atgagtacac      300

ttgtatgtgt ggtgtgtaca ggtgccatgt aagtgtgctt gtacatatat gcatgcatgt      360

gtcatatgca tctgtgtgtg catgtgtgtg gtgcacacat gtgttatgtc tgagtgtgcc      420

tgtatgtgtg ctatgtacac gtcatgtgtg agtgtgcttg catgtgcagt gtgtggatgc      480

tgcttgtacc tgtggtgtgt acctgtgtca tgggtgctca cacgtgcatg gagtgttgtg      540

tgtgtgcttg tgtgccccat gtgtgcatgt gtgtgtgcct cacacagatg cctgcatttg      600

cctaggcact tgcaagagga caccatgctg gctctcaaag atcacagggc cacctgagcc      660

ctgtgcacac cacagccagg ccatggctag accctgcaga gccacagggc gatgcctgtc      720

agccagggga cccagaacac ctcctgggct cctccccagc acatggctgg gctcctccag      780

caggcctgga tttgggaagg gcccgtggtg ggcaaggctg gtgctgggga gcaggcctgg      840

tggcctcaga gactcgccct gtgggcggag cagcctcaca gccaggtcga agtcagcact      900

ctgaccctgc cccacgcggg gagtgggcac cagtcccagg gcacagacgt gctgggtgat      960

taatctgggt gattaagcct cgggctgaga ggctgttgag agagaacacg ctccattgtg     1020

gagctggctc agcattcctt acggccatgg tggcaggggc tgtaaccaca gggacggcgg     1080

aagtggtgga gggtggtggg gtatggaggg aagcccagag ggctccgtgc aggaaggtgg     1140

agcctggtgc aatggagggg acagcaaggg ctcctcagac ctctgcgggg cccccactcc     1200

cctggtcacc tgttttgtct ctgatctggc ctgggtcggc cctcactcct ggccccacct     1260

catagccccc cctggtgggg ctccgctcca gcccttctcc ttcccagggg ccagtatgct     1320

ggccccaggg gtctcttggg gcgtgacctc ggcctccaga gaaccctgtc ccagctctgc     1380

ccttccctct ggggtctctg tagatgggac gctggtcaca gcagcctgtc tgatttgttc     1440

cctgtggcct aggttcctga gccccacagt gccaggggat ggatgccacc ggatctttga     1500

aagaccagtg tcaggccggg cgcagtggct cacgcctgta atcccagcac tttgggaggc     1560

cgaggtgggc ggatcacgaa gtcaggagat cgagaccatc ctggctaaca cagtgaaacc     1620

ccgtctccac taaaaataca aaaagttagc tgggcgtggt ggtgggcgcc tgtagtccca     1680

gctacttggg aggctgaggc aggagaatgg cgtgaaccgg ggaggcggag cttgcagtga     1740

gccgagatcg cgccattgca ctccagcctg ggtgacagag cgagactcgg tctcaaaaaa     1800

aaagaaaaaa aggaaagacc agtgtcttgg gagttgggaa acctgggctg gagactcact     1860

gcatgacccc tgagaagttg cacctcagaa cctcagtcct cgcatctgca gaatgggtct     1920

gtgaacacct cagctgcccg aacgtggatg ccgcaggctg acccagcact gagctctacc     1980

aagaccaggg gccagccgtg tgctccctcc aggcctgtgc ccagcgtgga gaggcctcgt     2040

cccgtgggcg ctggagtgga gccttcctgg tgtttgtgga catctctgga gagggccaga     2100

ggcaggtggg tgacacgggg catggctcaa tcatgggtgg tccagactgg agaggtaccc     2160

tcgggctggg agcggggagg ctggccaggg tagacttttg gggcctccat ggataccctc     2220

accatctgga atcggagagg ggcacggcac aaaggagggc ggggccaggg ccaggactgg     2280

agtcgggggc acctctgtgc caacaggggc cttggatctg gggtacagca tggttccccg     2340

gccctgaagg ggctggcgtg tgggacaggc ttcccaggaa tggataggca gggatggatg     2400

ctgcctgatt ggggcgggag gctggaggca gggcaggtgc aggcacctga gggcagcact     2460

cacctccaca ggggtccagg ggcctcccca gcctcagcac ctggcctggg ctcctgcctc     2520

cagagagcct ggccccaagg aagagtctag taagcttagt tcccatcggg cttccatgaa     2580

agcacaactg gcccggcagg aaaccgaatt aaaaagcaat atttgtatca gtggaagaca     2640

tttgctgaaa ggttaaatcc acatccggca gtgtgggcca tgagcctccg gcgtggtgtt     2700

catcaggcat gtctctcctc ctggcctggg cacctgagca ctggggccgc cctgggcaga     2760

gctggggcgg ggtgctgggg ggcctggagc tgcctcaccg agggatcctc agcagccgac     2820

cctgggggag gcaaatgaga ctctttctgg ggaccttgag gggagctcgg gggagccatg     2880

cagagcttca ccaggcctgg acactgggca tggaggctgg gccacccaag ggccatcacc     2940

agggactcag gtgggtgggc ctcagccctg ggtgacagaa gctcacgggc cgcagggcga     3000

ggccagaggc tgagccttca ggctgaggtc ttggaggcaa atccctccaa cgcccttctg     3060

agcaggcacc cagacctact gtgggcagga cccacaggag gtggaggcct ttggggaaca     3120

ctgtggaggg gcatagcatc tccgagagag gacagggtct gcactgggtg ctgagagaca     3180

gcaggggccg agcggtaggc ttccctgccc ccagggatgt tccagaggag cgcaagggag     3240

gggcattaat atcgtggcaa gaaagggcag gcattgcaga gtgagcagcg acggaactgg     3300

gttttgtggg atgcatagga gttcacccgg ataagaggtg ggtgaggaat gacactgcaa     3360

accggggatc acggagcccc aaatccttct gggccaggaa gtgggaaggg ttggggggtc     3420

ttccctttgc tttgactgag cactcagcct gcctgcagag ggcagcgagg agccacggag     3480

gggtgtggga cagggatgcc atggctgaag cagttttagg aaaggtccca ggggctattg     3540

ttgaagagag aacggggagc ggggagtccc acagctgaca ggagcagagt gggccctgag     3600

agatgccagc tctggctgcc acagtgacca gccggggtag gccttcgaga agtcagggag     3660

cgtctagggc ttctggctcc tgctgggccc agggtgtcat cttgggctgc caacaccaga     3720

aagcccagca gatacaggaa gccccaagcc ctgtcggaaa cggttcttct ccaggaggga     3780

cagcggtggc agcgttcagc cgcaggccat gcactctggg gccacgtcct tccctctgta     3840

cagtccagca ttgtcaaggc aggctctggc catctctgct gaccccagag ggatggggag     3900

gcctcccctt ccaccagaag ggccagaagc caccctgggc aggggcatca ctctccctgg     3960

gtggggcagc ggctgggagc aggaggtgcc agtgggcgtg ggctggatgc gggtgcctgc     4020

ggggcggaca tggaacttgg gggaggctct aggctggggt tgtcctcaag ggagttctca     4080

ggtcacccca gggtcaccct caacccgggg cctggtgggg tagaggagaa actgcaaagg     4140

tctctccaag gggaaggcat cagggccctc agcactgagg gacgtgcgtg ctctttaaag     4200

aaggggccac aggaccccga gggaagccag gagctagcag tgggccatag aggggctgag     4260

tggggtgggt ggaagccgtc cctggccctg gtcgccctgg caaccctggt ggggactgtg     4320

atgcaggagg tggcagccat ttggaaacgc gtggcgtctc cttagagatg tcttcttcag     4380

cctcccaggg tcctccacac tggacaggtg ggccctcctg ggacattctg gaccccacgg     4440

ggcgagcttg ggaagccgct gcaagggcca cacctgcagg gcccgggggc tgtgggcaga     4500

tggcactcct aggaaccacg tctatgagac acacggcctg gaatcttctg gagaagcaaa     4560

caaattgcct cctgacatct gaggctggag gctggattcc ccgtcttggg gctttctggg     4620

tcggtctgcc acgaggttct ggtgttcatt aaaagtgtgc ccctgggctg ccagaaagcc     4680

cctccctgtg tgctctcttg agggctgtgg ggccaagggg accctggctg tctcagcccc     4740

ccgcagagca cgagcccctg gtccccgcaa gcccgcgggc tgaggatgat tcagacaggg     4800

ctggggagtg aaggcaatta gattccacgg acgagccctt tctcctgcgc ctccctcctt     4860

cctcacccac ccccgcctcc atcaggcaca gcaggcaggg gtgggggatg taaggagggg     4920

aaggtggggg acccagaggg ggctttgacg tcagctcagc ttataagagg ctgctgggcc     4980

agggctgtgg agacggagcc cggacctcca cactgagcca tgcccacccc cgacgccacc     5040

acgccacagg ccaagggctt ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag     5100

gccatcatgg taagagggca ggtaggtgcc cggcggccgc agtggaccgg agcccagggc     5160

tggtgccagc tgcctctgct actccccagc ctggctggca gccccaggct cagggtccat     5220

gcaaacccct gggacgcggc gtggatgtgg aggcctgggc acagcggcat cccctgtgcc     5280

tggtgtttga gtccctgttg ggggagggtg aggtgatgcc tgtccctgtg tgtgcccctc     5340

ttaggccgac ctctctcggg ggtcgtgtgg gtctctgtgt cttgtttcat cttgaatctt     5400

aacgatcgga atgtggaaac aaatccatcc aaaaaatcca agatggccag aggtccccgg     5460

ctgctgcacc cagcccccac cctactccca cctgcccctg cctccctctg ccccagctgc     5520

cctagtcagc accccaacca gcctgcctgc ttggggaggc agccccaagg cccttcccag     5580

gctctagcag cagctcatgg tggggggtcc tgggcaaata gggggcaaaa ttcaaagggt     5640

atctgggctc tggggtgatt cccattggcc tgttcctccc ttatttccct cattcattca     5700

ttcattcatt cattcattca ccatggagtc tgtgttccct gtgacctgca ctcggaagcc     5760

ctgtgtacag gggactgtgt gggccaggct ggataatcgg gagcttttca gcccacagga     5820

ggggtcttcg gtgcctcctt gggcactcag aaccttgggc tccctggcac atttaaaatg     5880

ggtttttatt tatggacctt gattgaaatg tggtgtgagt tgtagcagtg tcatttccag     5940

gtaccttctc agggacacag ggcgccctcc cccgtcctcc cccgccctcc cctaccctcc     6000

cccaccaggc tccccatcag gcatcccctc cccagggcgc cccggggccc agcctcacag     6060

gctctccgtg gcctggaact gcagccccag ctgcatccta cacccccacc ccaagggtaa     6120

gtaagagggg actctgggag gggcttctgc tgctcccctt catgttccac aaccctggaa     6180

gctcaggatg aagctgattc ttctcttaca aggggcccag agccttcttg ggagttcagc     6240

tccaagggat gagccccagg tgtctgccaa gtccccctct gtccaggcct gggacggctc     6300

tgggatcgag gggtcagagg cgctgagccc agggagagac acctgcgccc agagctatga     6360

caaagggtgg agggatgaca aggcagccag gagcgggcgc ctgcggggtg gcacagaggg     6420

gcagggcccg aggacaggtg tcctgatggg agtgtgagaa agggtcccct gtgcggcagc     6480

caggagggta ggggggttgt tcactggggc cctgtggggg cagctccttc ctgagctgcc     6540

gttccctccc cggcagccga tgccactgtc catcaagaca tcgccctctt cccatcacta     6600

atccagttag cgcctggcct ggggatgagt gacacagcgt ctctgtctgt ctgctcgcca     6660

cagagtgggg agcaggcgag caccttccca gcccccactc ctcccccacc accactgctt     6720

ctgactgggc tgcccccatc gggaagggcg tgcaatgccc gcaggcacct cggctagcat     6780

ctgccccagc aggcacacag taggcgctca aaaacgtgct ctcatcccct gcctctgtgt     6840

gccatcagcg ctgcccgact gtgggaccag ctgtgggtgg aggtccccgg gtctcagcag     6900

gtggaggagg catgggtgcc ccttgtcccc acagtccccg cggttcattg ggcgcaggca     6960

gagcctcatc gaggacgccc gcaaggagcg ggaggcggcg gtggcagcag cggccgctgc     7020

agtcccctcg gagcccgggg accccctgga ggctgtggcc tttgaggaga aggaggggaa     7080

ggccgtgcta aacctgctct tctccccgag ggccaccaag ccctcggcgc tgtcccgagc     7140

tgtgaaggtg tttgaggtga gctggtggcc ttcgtgtccc tggggcaagt tcacctgtgg     7200

gtggggctgt gtgggctgag ttcctgaccc ctctatagca gaggtgcagc tgcccaggcc     7260

cccgaggccg gcacaggatg cagcagggga gtctcaggcc tcagctcagc ccccatggca     7320

tctagccaca cccccgtgtt tttgagggat cctgagccca cccctagggc tgaggctacc     7380

aagccccact gtgcctcttg ccttgcccat cccctggatc cccctcaccc accatttccc     7440

acgtgggggg ctcccagcag ggcagcacaa gaggcagggg cagggcagtg tgccctctcc     7500

cacccaccca gcacagtggc tcaggtgacc actgattgca ttagtcactc cggccccact     7560

gtgccccggg aggcaggtga cccagctccc ggaagaagct cccaaatgac attaaagcca     7620

gactccccgc cccccagctc ccagagccag ttttgtggcc cgagggccac tgcgacccac     7680

cgcccttgtt gctaggcaac aggaggtggg ggtggagcgg acccttctgg ccagtgtcct     7740

ggacgctcag gggccagtga gactcagggc ccatcctaca aacctggatg aggccaccag     7800

ggttgggggc accttctgac cagtggctga ggagccggac tgtgtggcat ggccttggga     7860

cacacacacc gagccgccca gaaccaggtt aagcctcaag cggtgacaac tcctggttag     7920

gcacgtaaca caaaatccaa cttgccagtg gcaaaccctg gcctggtggc cgacagctga     7980

cctgagcctg gaagaacggg atctgtgtgc tgctagcaca aaagtcaagg gcagggcctg     8040

gccagccagc cagatgtgcc tcctccccgc ccaccccacc ctctctctcc atctctgtct     8100

ctttctcctt ctctctctct tcctgctttt gctccctaag acgtttgaag ccaaaatcca     8160

ccatctagag acccggcccg cccagaggcc gcgagctggg ggcccccacc tggagtactt     8220

cgtgcgcctc gaggtgcgcc gaggggacct ggccgccctg ctcagtggtg tgcgccaggt     8280

gtcagaggac gtgcgcagcc ccgcggggcc caagggtgag gcggttttct gtccttgagg     8340

gccaccaaat gaccttgaga ggctggggtg caggggctcc tgcaggggga ccctacagtg     8400

accacgtggt ggtggcctgg ttccctctct gcgggctcca ctccgcaccc cgttttgcta     8460

cacatccgtg tccgggcctg gggccactcc aggatccccc cgcagctctc acagccccgg     8520

ctgcctctgc cccccggaag tcttgtaggg gaggctgctt caaggtgggt gacacagccc     8580

cacggctccg agctcaccaa gatctcttcc tccatcaccc ataaagtccc ctggttccca     8640

agaaaagtgt cagagctgga caagtgtcat cacctggtca ccaagttcga ccctgacctg     8700

gacttggacc acccggtgag tggtgcgccc ctcactcagg cctcctgccc ctgatcacat     8760

cccctaccct tagcccaacc ctggacagga gtctgtcggc tccaggagcc tccgtggcct     8820

gtgcccccac cccagcacag cctcctgacc cgtgcatccc ctctgccctc agggcttctc     8880

ggaccaggtg taccgccagc gcaggaagct gattgctgag atcgccttcc agtacaggca     8940

gtgaggggcc cctgcgctcg ggacccagac tccgtcctgc aggctgacgc tggacctggg     9000

gggtgggagg gaaggacaaa ggggaggacc catcttgtca ccagcatcag tgcctcctgc     9060

caggcagctc tgctccaggg ctttccatgt ccccaaatcc cagtggggaa actgaggccc     9120

aggggggcta gagcaacctg ccgaggccac atagccggct cacggcacag tcagctgggg     9180

tgcaccctcc tgtccatcct ccaacccaaa ggcctcgctg cactaggcgg gtgtggacct     9240

gtgcccagtg aagctccctc cctccctcct gcccttctca ctccccgagg ggacctgctg     9300

accactggcc ccctccccag cggcgacccg attccccgtg tggagtacac cgccgaggag     9360

attgccacct ggtgagacct ccgtgcagct aggggctggg gaggagcccg ggggatgcct     9420

cctggaatcc tggcgtgtga gggccgcctc cagggacctt ggcacaacag gagagactaa     9480

ggccgggaag aagagggact tgcagggctc agaatgttgg gttgggagga agaggctacc     9540

catcctgtcg ggccatcccc agtgtgctga gggaccgccc ctcatggccc cctatcccct     9600

gggattccct aaagccacca gcaaaagccc ctcccggggg cctgggtctt caggggtccc     9660

caagaggcct gcgttggtag gggctcaggc aggcagaggc acccacagtt caggaggggg     9720

gtttcgggca ctggggtggg gcattagagg gccctgagcc tggctgcccg caggaaggag     9780

gtctacacca cgctgaaggg cctctacgcc acgcacgcct gcggggagca cctggaggcc     9840

tttgctttgc tggagcgctt cagcggctac cgggaagaca atatccccca gctggaggac     9900

gtctcccgct tcctgaaggg tgtgcccaga cgggaggggc gcagagccgg ggggccgggg     9960

atggtcagcc aagcgcccca ccccagcgcg gctccagccc gtcccggctc ggcagtgacc    10020

cgcgtggccc cttgcagagc gcacgggctt ccagctgcgg cctgtggccg gcctgctgtc    10080

cgcccgggac ttcctggcca gcctggcctt ccgcgtgttc cagtgcaccc agtatatccg    10140

ccacgcgtcc tcgcccatgc actcccctga gccgtgagtg cgcgccctgg ccgccagccc    10200

gagggtgggg ggtgcgacgg gcggcccctc agcccccttc tccctcctac gcgcagggac    10260

tgctgccacg agctgctggg gcacgtgccc atgctggccg accgcacctt cgcgcagttc    10320

tcgcaggtac gccgcggcct cggagggagc cggggtcacc caggggctgg cttggcgccg    10380

ggggcgggcg gggatcgatg tgcgggtggg tgaagtgtgc tgcctgctcc cgggccccgc    10440

caaggaggct cggcgccccg agggtcgcgc ggcatagggc ggggctggag cggagcctcc    10500

cacggcctgt gctgccacct gccggctacc tgggaacggc gcccacgggc ttaggaatgt    10560

ggtcaaggag ggctgcctgg aggaggaggc ccggtggagg tgcggatcct gggcggccag    10620

ggaaggtctc tgccgccagg gaagtgtccc agagacccct ggaggggctg ctgacacccc    10680

cggtgccccc acctcgagca tgacccaggg ctgcctctcc ccatccttca tcctccctgc    10740

tccacaggac attggcctgg cgtccctggg ggcctcggat gaggaaattg agaagctgtc    10800

cacggtgggt tgacccctcc ctgcagggcc tggggtgtgg gtttgggggt ctgaatccag    10860

gcctcaccct cttgccgtcc aggctgaggc ctctccttcc acccacgaat tgtgaccctc    10920

accctggcct gcctgcatcc tggcctggcc tccctggggg tggtatcctg gtcacgggtg    10980

accaggggct gcccggtggg cggcagctgt ctctgggctg atgctgcccg gcttccccgc    11040

agctgtactg gttcacggtg gagttcgggc tgtgtaagca gaacggggag gtgaaggcct    11100

atggtgccgg gctgctgtcc tcctacgggg agctcctggt gagagtctct ccttgctgca    11160

gcccccagca gaggggcagg gctgggggac ggtgcaggga ggggacaggc tcccagtggg    11220

aggaaactga ggcctggacc tccaggactc aggctctgtt tgggagaagg cttgtctctg    11280

cccagtcctc accccacatt atcccaggcc tccgaaggcc cggcggggga gatgggggtg    11340

actctaccca aggaacccac ccagcgtcag gccacggtgc cccagttccc tcggggacct    11400

gggtgcagtg gagtcagtga tgccattggc ctcctgccag cactgcctgt ctgaggagcc    11460

tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag ccctaccaag accagacgta    11520

ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc aaggacaagc tcaggtgggc    11580

taggctgcta gggcaagccc cccatggtgc ccccaaactg ggccagccag gccttccttc    11640

tggccttgag cagggctgga cctgtgagcc caggtcacag atgagaaaac cgacccctgg    11700

ttgcagcagc ccccacacag cagggacacc atccgtgaga aggaccccag cgtctgggga    11760

ggggcagacc tacaggactg ggggctgctg ggtggccggg tcaaggccag tcttggaggt    11820

gctgacagag cctgagcttt gtgaggacgt cctgtggaac ctgtcccggc cccctgccct    11880

gggatgggga gaagtcaggg ggatagacag agtcaaggtg ggggacaggg cgggagtggg    11940

gtccccaggg ctgggggcct ttggtgcagt gaccagagtg tcaggagagg ggagcaaagc    12000

cctctagcct catcctcata aaaggtctca tcattttccc tccagcctct tatgcactgg    12060

ggaaactgag gccaggggct atgtgtccag cggacagggg tgctgaattc cacccacagg    12120

cttagggata tggtcaagga aagcttcctg gaggaggccc agtggaggtt cagggaggga    12180

tggggtgccc ggcagtctct agtggaaaag gcgcctagcc tatctccccc atgaaccccc    12240

tcacccagcc ctggaagagg cctcagtgtc ccgcctgtga ccagttggct cagaaaagcc    12300

ctgggagctc tgagccactg tgaaggtgga aacgcggccc ctggcctccc ctctcctgga    12360

ggctgcagac tctgcccgcc agttgacgag ggctctgccg ctctcctccc caggagctat    12420

gcctcacgca tccagcgccc cttctccgtg aagttcgacc cgtacacgct ggccatcgac    12480

gtgctggaca gcccccaggc cgtgcggcgc tccctggagg gtgtccagga tgagctggac    12540

acccttgccc atgcgctgag tgccattggc taggtgcacg gcgtccctga gggcccttcc    12600

caacctcccc tggtcctgca ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg    12660

ggtgcccccc atgccctccc tgctgccagg ctcccactgc ccctgcacct gcttctcagc    12720

gcaacagctg tgtgtgcccg tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc    12780

tcccagggtc ctgggggctg ctgcactgcc ctccgccctt ccctgacact gtctgctgcc    12840

ccaatcaccg tcacaataaa agaaactgtg gtctctacac ctgcctggcc ccacatctgt    12900

gccacagaga cagaccctgg gatcctcaga ctcccacacc cccaccccag cctcactcag    12960

aggtttcgcc ctggcctcct tcctcctctg ggagatggct ggccgccctg gccaggcagc    13020

tggcccctcc gggcctggtt tccccgctca ccctgaggcc ccgcccagct ctgagcccca    13080

agcagctcca gaggctcggg caccctggcc gagctgcccc atctccgtgg ggtgccctcc    13140

caaggtgggg agccacgtga cagtgggagg gcctctctca ggcctggcag ggagcagggg    13200

tcacaaactg tgctggctgg gggtggtctc agaggtgggc ctgcaggcct aaccctccct    13260

gctgacaggg ctcccagccc ttgagagaaa cagggatgga ggaacagctg ccctgatgcc    13320

ctcacccacc cggagcaggc cctgcgaacc aaggggaacc tcagtgtggc ccccagcatg    13380

tgtgctgatg gggagggtct ggctgagctg gtgcccaggc agatggtctg ggcctgtctc    13440

cccagcgagg caggatgggg gctggatttc agactctgta agatgcccct ggcttactcg    13500

aggggcctgg acattgccct ccagagagag cacccaacac cctccaggct tgaccggcca    13560

gggtgtcccc ttcctacctt ggagagagca gccccagggc atcctgcagg gggtgctggg    13620

acaccagctg gccttcaagg tctctgcctc cctccagcca ccccactaca cgctgctggg    13680

atcctggatc tcagctcccc ggccgacaac actggcaaac tcctactcat ccacgaaggc    13740

cctcctgggc atggtggtcc ttcccagcct ggcagtctgt tcctcacaca ccttgttagt    13800

gcccagcccc tgaggttgca gctgggggtg tctctgaagg gctgtgagcc cccaggaagc    13860

cctggggaag tgcctgcctt gcctcccccc ggccctgcca gcgcctggct ctgccctcct    13920

acctgggctc cccccatcca gcctccctcc ctacacactc ctctcaagga ggcacccatg    13980

tcctctccag ctgccgggcc tcagagcact gtggcgtcct ggggcagcca ccgcatgtcc    14040

tgctgtggca tggctcaggg tggaaagggc ggaagggagg ggtcctgcag atagctggtg    14100

cccactacca aacccgctcg gggcaggaga gccaaaggct gggtgtgtgc agagcggccc    14160

cgagaggttc cgaggctgag gccagggtgg gacataggga tgcgaggggc cggggcacag    14220

gatactccaa cctgcctgcc cccatggtct catcctcctg cttctgggac ctcctgatcc    14280

tgcccctggt gctaagaggc aggtaggggc tgcaggcagc agggctcgga gcccatgccc    14340

cctcaccatg ggtcaggctg gacctccagg tgcctgttct ggggagctgg gagggccgga    14400

ggggtgtacc ccaggggctc agcccagatg acactatggg ggtgatggtg tcatgggacc    14460

tggccaggag aggggagatg ggctcccaga agaggagtgg gggctgagag ggtgcctggg    14520

gggccaggac ggagctgggc cagtgcacag cttcccacac ctgcccaccc ccagagtcct    14580

gccgccaccc ccagatcaca cggaagatga ggtccgagtg gcctgctgag gacttgctgc    14640

ttgtccccag gtccccaggt catgccctcc ttctgccacc ctggggagct gagggcctca    14700

gctggggctg ctgtcctaag gcagggtggg aactaggcag ccagcaggga ggggacccct    14760

ccctcactcc cactctccca cccccaccac cttggcccat ccatggcggc atcttgggcc    14820

atccgggact ggggacaggg gtcctgggga caggggtgtg gggacagggg tcctggg       14877


<210> 9
<211> 382
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Asp Gly Leu Lys Met Glu Glu Asn Phe Gln Ser Ala Ile Asp 
1               5                   10                  15      


Thr Ser Ala Ser Phe Ser Ser Leu Leu Gly Arg Ala Val Ser Pro Lys 
            20                  25                  30          


Ser Val Cys Glu Gly Cys Gln Arg Val Ile Leu Asp Arg Phe Leu Leu 
        35                  40                  45              


Arg Leu Asn Asp Ser Phe Trp His Glu Gln Cys Val Gln Cys Ala Ser 
    50                  55                  60                  


Cys Lys Glu Pro Leu Glu Thr Thr Cys Phe Tyr Arg Asp Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Lys Tyr Asp Tyr Glu Lys Leu Phe Ala Val Lys Cys Gly Gly 
                85                  90                  95      


Cys Phe Glu Ala Ile Ala Pro Asn Glu Phe Val Met Arg Ala Gln Lys 
            100                 105                 110         


Ser Val Tyr His Leu Ser Cys Phe Cys Cys Cys Val Cys Glu Arg Gln 
        115                 120                 125             


Leu Gln Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Glu Arg Glu Leu Leu Ser Leu Val Ser Pro 
145                 150                 155                 160 


Ala Ala Ser Asp Ser Gly Lys Ser Asp Asp Glu Glu Ser Leu Cys Lys 
                165                 170                 175     


Ser Ala His Gly Ala Gly Lys Gly Thr Ala Glu Glu Gly Lys Asp His 
            180                 185                 190         


Lys Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg Arg 
        195                 200                 205             


Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys Val 
    210                 215                 220                 


Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val Gln 
225                 230                 235                 240 


Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg Arg 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Asp Gln Gln Asn Thr Gln Arg Leu Ser Ser 
            260                 265                 270         


Ala Gln Thr Asn Gly Gly Gly Ser Ala Gly Met Glu Gly Ile Met Asn 
        275                 280                 285             


Pro Tyr Thr Ala Leu Pro Thr Pro Gln Gln Leu Leu Ala Ile Glu Gln 
    290                 295                 300                 


Ser Val Tyr Ser Ser Asp Pro Phe Arg Gln Gly Leu Thr Pro Pro Gln 
305                 310                 315                 320 


Met Pro Gly Asp His Met His Pro Tyr Gly Ala Glu Pro Leu Phe His 
                325                 330                 335     


Asp Leu Asp Ser Asp Asp Thr Ser Leu Ser Asn Leu Gly Asp Cys Phe 
            340                 345                 350         


Leu Ala Thr Ser Glu Ala Gly Pro Leu Gln Ser Arg Val Gly Asn Pro 
        355                 360                 365             


Ile Asp His Leu Tyr Ser Met Gln Asn Ser Tyr Phe Thr Ser 
    370                 375                 380         


<210> 10
<211> 5310
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (901)..(1000)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1301)..(1400)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1821)..(1920)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (2881)..(2980)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3461)..(3560)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4401)..(4500)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4801)..(4900)
<223> a, c, t, g, unknown or other

<400> 10
gtataggttg gggcggagtc ggattcggga tggaaaacct ggggcaaggg atgtaggtgg       60

gggtgagggg ggcaggagaa ggagaaacgc agttgggggg cggaggccta agtacataac      120

gtgttgactt caagtgaaat cagatcagcc agagcagttc gctgtgactg atctctcctc      180

ccaccctaca ttctcttggc tggaccctat cctcctggct gattctggtc gccctggaca      240

ctccctcagt tctttcccag gagtgcggtg gctgctggcg ccgagtccca gcgggcacgg      300

acgtcagacg catcgtttct tctcctctac aggtcctccc ggcccggccc gaacatgctg      360

gacggcctaa agatggagga gaacttccaa agcgcgatcg acacctcggc ctccttctcc      420

tcgctgctgg gtgagtgttc aggccgtgcg tcctgggcgc actctctttc cgcttggcgc      480

tgagctctgg agccccgctc tctgggacct ggtccgcgat agggaagcta gcgcccctct      540

tcatacacta aattgagccc catcactatc tgtccgtcag tgcttgtggg tcgtccctac      600

ccaaataaat ccaacaagcc gccccaggcc tcacgcactg ggcaccgaat tccccaaagc      660

cgcgaggggc gggcgagctt gttcgtaggc gtctgagtgg caagtgatta aaaataccca      720

gggctggatt tttaatctcg gagctgatcg acgtctcata aatgccgccc tcttctcgcg      780

gcctagaggc aatagcatcc gagacccgag gcctggagcg cccaagttcg aggaggcttc      840

tctcccccac caactccagc cccaatttca gccatgggca aggccgagag agacttttct      900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gggtcccggc caggtttggc     1020

atggtctacc tgcccgggct gctcacccgc caacgtctgt tgtggctaca ggcagagcgg     1080

tgagccccaa gtctgtctgc gagggctgtc agcgggtcat cttggacagg tttctgctgc     1140

ggctcaacga cagcttctgg catgagcagt gcgtgcagtg cgcctcctgc aaagagcccc     1200

tggagaccac ctgcttctac cgggacaaga agctgtactg caagtatgac tacgagaagt     1260

aagtggccgc acccccgcag cgctccccgc gcactggcat nnnnnnnnnn nnnnnnnnnn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn nnnnnnnnnn atcccagttc ttgaagttcc ttttgctgtt gacttcaggg     1440

gagacccagg accaagccag attttactca tggtgcatgt acttcctttc tccctgctgc     1500

caggctgttt gctgttaaat gtgggggctg cttcgaggcc atcgctccca atgagtttgt     1560

tatgcgggcc cagaagagtg tataccacct gagctgcttc tgctgctgtg tctgcgagcg     1620

acagcttcag aagggtgatg agtttgtcct gaaggagggg cagctgctct gcaaagggga     1680

ctatgagaag gagcgggagc tgctcagcct ggtgagccca gcagcctcag actcaggtga     1740

gtgccaggtg gtgggcaggg ctgcggtggg gtgggtagag tggagttggg tggctgtctg     1800

cattgtttct tccctagatg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1920

catacagctc caggaactgg ctttcaggga ctcacaacat tgtcttttgc ttctttcagg     1980

taaaagtgat gatgaagaaa gtctctgcaa gtcagcccat ggggcaggga aaggaactgc     2040

tgaggaaggc aaggaccata agcgccccaa acgtccgaga accatcttga caactcaaca     2100

gaggcgagca ttcaaggcct catttgaagt atcctccaag ccctgcagga aggtatagga     2160

gggagcaggg aggaaaagga gctgggcccc acttctctgt gtgcactcag acccctctgg     2220

gatctcagtg ggcattgggg gtcacagtgg tgaggaaggc tgttcagaca gagcctgcac     2280

aggcggctca agcctgttgg agactccaga gatcactaag ctgtggccag ggtgtgatag     2340

actctcctga agctttcatg catgcacacc aactccaaat ggcccctgtc acacctttca     2400

tttcatagag cacaatggga acagtaataa tgataggtgt ccattgtggt gtagacccag     2460

atgctgtaaa gcaaagagta taaaaacaca gtggcttgca gtactctttt ttgagtctgg     2520

ctttttccac ttggtgtggt ggtttgggga ttcattcatt cctatttcag cattccactg     2580

tataggtgtg ccatgattgg tttgtccatg cacctgttga tgggtgtttg gggttgtttc     2640

tagtttggga ctgtttcaaa taggactgct atggacattc atgtaaaaaa aaatacagtg     2700

gtttaatgag acaggagttt attctcttct gtcacagtcc agaggtgagc aaggcaaggc     2760

tggtgggtgg ctctgttatc catctcctgt gtccaagcga ctgctccagt tgtcaccatg     2820

tttccagtca ccaggtagag aaagaggaaa tggagggcaa gcgccctgct ttttaaggat     2880

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     2940

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn atgcatatgc atggcttata     3000

gctaaagcac aacaatagac taaagtctaa accacttgaa ggcctaattt ccagagcaag     3060

agaaatccag aaacacctct tgggaatgca catgtaaatt aataattatt attttgtttc     3120

tttacctggt gaaggacttt ctttctacct gaagggaagc aatgttctcg tgtttgtgtg     3180

tatgctcaac attaaaaact attcagctcc taaagcagat acagtctttt ggcctcctca     3240

agtattatat aggagatgtt ctacctccta ccctgagatg ccagtgtgtc tacatttctc     3300

gttcaatttt tccaaggtga gagagactct ggctgcagag acagggctga gtgtccgtgt     3360

cgtccaggtg tggttccaaa accagagagc gaaggtaacc tgcttcttac ttttatctgt     3420

ccccatgttg ctggtttcct gaaataatca cagtaggaca nnnnnnnnnn nnnnnnnnnn     3480

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     3540

nnnnnnnnnn nnnnnnnnnn agccctctcc cggggaaggt gtcacttcca ggccccccct     3600

tactttgtga acatgctgca ggccacctga cttctaatcc tatggtcctc tccttatcag     3660

atgaagaagc tggccaggcg acagcagcag cagcagcaag atcagcagaa cacccagagg     3720

ctgagctctg gtaagctggt gcctcctccc aggcagttct ggctggaatc caggctgttc     3780

ctaccagagg cctcccacta cccagctctt tggatgacat atctggactc agtgaagcct     3840

agaccacacc cactggagaa ataaggcctt caagggaaga ctgagccacg aggaacttgt     3900

gagagggttg agggctcctg agctgcaggc ttagaactgc tgattgggga tggcactgac     3960

cttatccaca gcgtccaggc ctggatccca ccacagcgtc agggactgct tgcagagtca     4020

cagatacgtt cagtttctca tcttgcttag ttctccttcc aggctaattg atttaataga     4080

agacacctcg gtgacttggc tctttccaaa ataacataaa gtagtaaaaa taatgatagt     4140

aaaataacaa tgccttcctt tgttgaacac tcttatagat tggtgttctc atacatgctg     4200

acttgacttt tacaacaccc attcctggag gcgagtggag aagttgttat tatccctatg     4260

tcacagatga gcaaacaaag gctctgcaag attgaatgtg gccctagatc ggtaagggca     4320

gggggctggg actagaactc taactgtgtt ccacaggcca tgggccttct catctctacc     4380

cagatgtgct tttgaaaaag nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4500

cacgttgaga atgacctggc ttcttctttg ttccacagct cagacaaacg gtggtgggag     4560

tgctgggatg gaaggaatca tgaaccccta cacggctctg cccaccccac agcagctcct     4620

ggccatcgag cagagtgtct acagctcaga tcccttccga cagggtctca ccccacccca     4680

gatgcctgga gaccacatgc acccttatgg taagagggac ttaagcccct cgggccctct     4740

cataacttgt gtgggtttct cattccctcc taaacacatc taggcagttc ccagatgctc     4800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aaatgagtca cttcttcaag     4920

accctcatgc cagtgtttca tctccatttc aggtgccgag ccccttttcc atgacctgga     4980

tagcgacgac acctccctca gtaacctggg tgattgtttc ctagcaacct cagaagctgg     5040

gcctctgcag tccagagtgg gaaaccccat tgaccatctg tactccatgc agaattctta     5100

cttcacatct tgagtcttcc cctagagttc tgtgactagg ctcccatatg gaacaaccat     5160

attctttgag gggtcactgg ctttaggaca gggaggccag ggaagaggtg ggttggggag     5220

ggagttttgt tggggatgct gttgtataat gatatggtgt agctcagcat ttccaaagac     5280

tgaatacatt atggattgca tagtttaatg                                      5310


<210> 11
<211> 655
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala 
    50                  55                  60                  


Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly 
            100                 105                 110         


Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro 
        115                 120                 125             


Gly Pro Leu Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro 
    130                 135                 140                 


Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp 
145                 150                 155                 160 


Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser 
                165                 170                 175     


Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys 
            180                 185                 190         


Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly 
        195                 200                 205             


Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile 
    210                 215                 220                 


Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn 
225                 230                 235                 240 


Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser 
                245                 250                 255     


Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys 
            260                 265                 270         


Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro 
        275                 280                 285             


Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn 
    290                 295                 300                 


Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn 
305                 310                 315                 320 


Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp 
                325                 330                 335     


Asp Leu Gly Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala 
            340                 345                 350         


Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro 
        355                 360                 365             


Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro 
    370                 375                 380                 


Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln 
385                 390                 395                 400 


Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser 
                405                 410                 415     


Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser 
            420                 425                 430         


Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser 
        435                 440                 445             


Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu 
    450                 455                 460                 


Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val 
465                 470                 475                 480 


Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val 
                485                 490                 495     


Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser 
            500                 505                 510         


His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala 
        515                 520                 525             


Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser 
    530                 535                 540                 


Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr 
545                 550                 555                 560 


Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly 
                565                 570                 575     


Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu 
            580                 585                 590         


Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu 
        595                 600                 605             


Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp 
    610                 615                 620                 


Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser 
625                 630                 635                 640 


Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650                 655 


<210> 12
<211> 5738
<212> DNA
<213> Homo sapiens

<400> 12
gcagccgcca cattcaacag gcagcagcgc agcgggcgcg ccgctgggga gagcaagcgg       60

cccgcggcgt ccgtccgtcc ttccgtccgc ggccctgtca gctggagcgc ggcgcaggct      120

ctgccccggc ccggcggctc tggccggccg tccagtccgt gcggcggacc ccgaggagcc      180

tcgatgtgga tggccccgcg aagttaagtt ctgggctcgc gcttccactc cgccgcgcct      240

tcctcccagt ttccgtccgc tcgccgcacc ggcttcgttc ccccaaatct cggaccgtcc      300

cttcgcgccc cctccccgtc cgcccccagt gctgcgttct ccccctcttg gctctcctgc      360

ggctggggga ggggcggggg tcaccatggc cgaggcgcct caggtggtgg agatcgaccc      420

ggacttcgag ccgctgcccc ggccgcgctc gtgcacctgg ccgctgccca ggccggagtt      480

tagccagtcc aactcggcca cctccagccc ggcgccgtcg ggcagcgcgg ctgccaaccc      540

cgacgccgcg gcgggcctgc cctcggcctc ggctgccgct gtcagcgccg acttcatgag      600

caacctgagc ttgctggagg agagcgagga cttcccgcag gcgcccggct ccgtggcggc      660

ggcggtggcg gcggcggccg ccgcggccgc caccgggggg ctgtgcgggg acttccaggg      720

cccggaggcg ggctgcctgc acccagcgcc accgcagccc ccgccgcccg ggccgctgtc      780

gcagcacccg ccggtgcccc ccgccgccgc tgggccgctc gcggggcagc cgcgcaagag      840

cagctcgtcc cgccgcaacg cgtggggcaa cctgtcctac gccgacctca tcaccaaggc      900

catcgagagc tcggcggaga agcggctcac gctgtcgcag atctacgagt ggatggtcaa      960

gagcgtgccc tacttcaagg ataagggtga cagcaacagc tcggcgggct ggaagaattc     1020

aattcgtcat aatctgtccc tacacagcaa gttcattcgt gtgcagaatg aaggaactgg     1080

aaaaagttct tggtggatgc tcaatccaga gggtggcaag agcgggaaat ctcctaggag     1140

aagagctgca tccatggaca acaacagtaa atttgctaag agccgaagcc gagctgccaa     1200

gaagaaagca tctctccagt ctggccagga gggtgctggg gacagccctg gatcacagtt     1260

ttccaaatgg cctgcaagcc ctggctctca cagcaatgat gactttgata actggagtac     1320

atttcgccct cgaactagct caaatgctag tactattagt gggagactct cacccattat     1380

gaccgaacag gatgatcttg gagaagggga tgtgcattct atggtgtacc cgccatctgc     1440

cgcaaagatg gcctctactt tacccagtct gtctgagata agcaatcccg aaaacatgga     1500

aaatcttttg gataatctca accttctctc atcaccaaca tcattaactg tttcgaccca     1560

gtcctcacct ggcaccatga tgcagcagac gccgtgctac tcgtttgcgc caccaaacac     1620

cagtttgaat tcacccagcc caaactacca aaaatataca tatggccaat ccagcatgag     1680

ccctttgccc cagatgccta tacaaacact tcaggacaat aagtcgagtt atggaggtat     1740

gagtcagtat aactgtgcgc ctggactctt gaaggagttg ctgacttctg actctcctcc     1800

ccataatgac attatgacac cagttgatcc tggggtagcc cagcccaaca gccgggttct     1860

gggccagaac gtcatgatgg gccctaattc ggtcatgtca acctatggca gccaggcatc     1920

tcataacaaa atgatgaatc ccagctccca tacccaccct ggacatgctc agcagacatc     1980

tgcagttaac gggcgtcccc tgccccacac ggtaagcacc atgccccaca cctcgggtat     2040

gaaccgcctg acccaagtga agacacctgt acaagtgcct ctgccccacc ccatgcagat     2100

gagtgccctg gggggctact cctccgtgag cagctgcaat ggctatggca gaatgggcct     2160

tctccaccag gagaagctcc caagtgactt ggatggcatg ttcattgagc gcttagactg     2220

tgacatggaa tccatcattc ggaatgacct catggatgga gatacattgg attttaactt     2280

tgacaatgtg ttgcccaacc aaagcttccc acacagtgtc aagacaacga cacatagctg     2340

ggtgtcaggc tgagggttag tgagcaggtt acacttaaaa gtacttcaga ttgtctgaca     2400

gcaggaactg agagaagcag tccaaagatg tctttcacca actccctttt agttttcttg     2460

gttaaaaaaa aaaacaaaaa aaaaaaccct ccttttttcc tttcgtcaga cttggcagca     2520

aagacatttt tcctgtacag gatgtttgcc caatgtgtgc aggttatgtg ctgctgtaga     2580

taaggactgt gccattggaa atttcattac aatgaagtgc caaactcact acaccatata     2640

attgcagaaa agattttcag atcctggtgt gctttcaagt tttgtatata agcagtagat     2700

acagattgta tttgtgtgtg tttttggttt ttctaaatat ccaattggtc caaggaaagt     2760

ttatactctt tttgtaatac tgtgatgggc ctcatgtctt gataagttaa acttttgttt     2820

gtactacctg ttttctgcgg aactgacgga tcacaaagaa ctgaatctcc attctgcatc     2880

tccattgaac agccttggac ctgttcacgt tgccacagaa ttcacatgag aaccaagtag     2940

cctgttatca atctgctaaa ttaatggact tgttaaactt ttggaaaaaa aaagattaaa     3000

tgccagcttt gtacaggtct tttctatttt tttttgttta ttttgttatt tgcaaatttg     3060

tacaaacatt taaatggttc taatttccag ataaatgatt tttgatgtta ttgttgggac     3120

ttaagaacat ttttggaata gatattgaac tgtaataatg ttttcttaaa actagagtct     3180

actttgttac atagtcagct tgtaaatttt gtggaaccac aggtatttgg ggcagcattc     3240

ataattttca ttttgtattc taactggatt agtactaatt ttatacatgc ttaactggtt     3300

tgtacacttt gggatgctac ttagtgatgt ttctgactaa tcttaaatca ttgtaattag     3360

tacttgcata ttcaacgttt caggccctgg ttgggcagga aagtgatgta tagttatgga     3420

cactttgcgt ttcttattta ggataactta atatgttttt atgtatgtat tttaaagaaa     3480

tttcatctgc ttctactgaa ctatgcgtac tgcatagcat caagtcttct ctagagacct     3540

ctgtagtcct gggaggcctc ataatgtttg tagatcagaa aagggagatc tgcatctaaa     3600

gcaatggtcc tttgtcaaac gagggatttt gatccacttc accattttga gttgagcttt     3660

agcaaaagtt tcccctcata attctttgct cttgtttcag tccaggtgga ggttggtttt     3720

gtagttctgc cttgaggaat tatgtcaaca ctcatacttc atctcattct cccttctgcc     3780

ctgcagatta gattacttag cacactgtgg aagtttaagt ggaaggaggg aatttaaaaa     3840

tgggacttga gtggtttgta gaatttgtgt tcataagttc agatgggtag caaatggaat     3900

agaacttact taaaaattgg ggagatttat ttgaaaacca gctgtaagtt gtgcattgag     3960

attatgttaa aagccttggc ttaagaattt gaaaatttct ttagcctgta gcaacctaaa     4020

ctgtaattcc tatcattatg ttttattact ttccaattac ctgtaactga cagaccaaat     4080

taattggctt tgtgtcctat ttagtccatc agtattttca agtcatgtgg aaagcccaaa     4140

gtcatcacaa tgaagagaac aggtgcacag cactgttcct cttgtgttct tgagaaggat     4200

ctaatttttc tgtatatagc ccacatcaca cttgctttgt cttgtatgtt aattgcatct     4260

tcattggctt ggtatttcct aaatgtttaa caagaacaca agtgttcctg ataagatttc     4320

ctacagtaag ccagctctat tgtaagcttc ccactgtgat gatcattttt ttgaagattc     4380

attgaacagc caccactcta tcatcctcat tttggggcag tccaagacat agctggtttt     4440

agaaacccaa gttcctctaa gcacagcctc ccgggtatgt aactgaactt ggtgccaaag     4500

tacttgtgta ctaatttcta ttactacgta ctgtcacttt cctcccgtgc cattactgca     4560

tcataataca aggaacctca gagcccccat ttgttcatta aagaggcaac tacagccaaa     4620

atcactgtta aaatcttact acttcatgga gtagctctta ggaaaatata tcttcctcct     4680

gagtctgggt aattatacct ctcccaagcc cccattgtgt gttgaaatcc tgtcatgaat     4740

ccttggtagc tctctgagaa cagtgaagtc cagggaaagg catctggtct gtctggaaag     4800

caaacattat gtggcctctg gtagtttttt tcctgtaaga atactgactt tctggagtaa     4860

tgagtatata tcagttattg tacatgattg ctttgtgaaa tgtgcaaatg atatcaccta     4920

tgcagccttg tttgatttat tttctctggt ttgtactgtt attaaaagca tattgtatta     4980

tagagctatt cagatatttt aaatataaag atgtattgtt tccgtaatat agacgtatgg     5040

aatatattta ggtaatagat gtattacttg gaaagttctg ctttgacaaa ctgacaaagt     5100

ctaaatgagc acatgtatcc cagtgagcag taaatcaatg gaacatccca agaagaggat     5160

aaggatgctt aaaatggaaa tcattctcca acgatataca aattggactt gttcaactgc     5220

tggatatatg ctaccaataa ccccagcccc aacttaaaat tcttacattc aagctcctaa     5280

gagttcttaa tttataacta attttaaaag agaagtttct tttctggttt tagtttggga     5340

ataatcattc attaaaaaaa atgtattgtg gtttatgcga acagaccaac ctggcattac     5400

agttggcctc tccttgaggt gggcacagcc tggcagtgtg gccaggggtg gccatgtaag     5460

tcccatcagg acgtagtcat gcctcctgca tttcgctacc cgagtttagt aacagtgcag     5520

attccacgtt cttgttccga tactctgaga agtgcctgat gttgatgtac ttacagacac     5580

aagaacaatc tttgctataa ttgtataaag ccataaatgt acataaatta tgtttaaatg     5640

gcttggtgtc tttcttttct aattatgcag aataagctct ttattaggaa ttttttgtga     5700

agctattaaa tacttgagtt aagtcttgtc agccacaa                             5738


<210> 13
<211> 457
<212> PRT
<213> Homo sapiens

<400> 13
Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         


Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     


Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         


Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             


Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         


<210> 14
<211> 2428
<212> DNA
<213> Homo sapiens

<400> 14
cccgcccact tccaactacc gcctccggcc tgcccaggga gagagaggga gtggagccca       60

gggagaggga gcgcgagaga gggagggagg aggggacggt gctttggctg actttttttt      120

aaaagagggt gggggtgggg ggtgattgct ggtcgtttgt tgtggctgtt aaattttaaa      180

ctgccatgca ctcggcttcc agtatgctgg gagcggtgaa gatggaaggg cacgagccgt      240

ccgactggag cagctactat gcagagcccg agggctactc ctccgtgagc aacatgaacg      300

ccggcctggg gatgaacggc atgaacacgt acatgagcat gtcggcggcc gccatgggca      360

gcggctcggg caacatgagc gcgggctcca tgaacatgtc gtcgtacgtg ggcgctggca      420

tgagcccgtc cctggcgggg atgtcccccg gcgcgggcgc catggcgggc atgggcggct      480

cggccggggc ggccggcgtg gcgggcatgg ggccgcactt gagtcccagc ctgagcccgc      540

tcggggggca ggcggccggg gccatgggcg gcctggcccc ctacgccaac atgaactcca      600

tgagccccat gtacgggcag gcgggcctga gccgcgcccg cgaccccaag acctacaggc      660

gcagctacac gcacgcaaag ccgccctact cgtacatctc gctcatcacc atggccatcc      720

agcagagccc caacaagatg ctgacgctga gcgagatcta ccagtggatc atggacctct      780

tccccttcta ccggcagaac cagcagcgct ggcagaactc catccgccac tcgctctcct      840

tcaacgactg tttcctgaag gtgccccgct cgcccgacaa gcccggcaag ggctccttct      900

ggaccctgca ccctgactcg ggcaacatgt tcgagaacgg ctgctacctg cgccgccaga      960

agcgcttcaa gtgcgagaag cagctggcgc tgaaggaggc cgcaggcgcc gccggcagcg     1020

gcaagaaggc ggccgccgga gcccaggcct cacaggctca actcggggag gccgccgggc     1080

cggcctccga gactccggcg ggcaccgagt cgcctcactc gagcgcctcc ccgtgccagg     1140

agcacaagcg agggggcctg ggagagctga aggggacgcc ggctgcggcg ctgagccccc     1200

cagagccggc gccctctccc gggcagcagc agcaggccgc ggcccacctg ctgggcccgc     1260

cccaccaccc gggcctgccg cctgaggccc acctgaagcc ggaacaccac tacgccttca     1320

accacccgtt ctccatcaac aacctcatgt cctcggagca gcagcaccac cacagccacc     1380

accaccacca accccacaaa atggacctca aggcctacga acaggtgatg cactaccccg     1440

gctacggttc ccccatgcct ggcagcttgg ccatgggccc ggtcacgaac aaaacgggcc     1500

tggacgcctc gcccctggcc gcagatacct cctactacca gggggtgtac tcccggccca     1560

ttatgaactc ctcttaagaa gacgacggct tcaggcccgg ctaactctgg caccccggat     1620

cgaggacaag tgagagagca agtgggggtc gagactttgg ggagacggtg ttgcagagac     1680

gcaagggaga agaaatccat aacaccccca ccccaacacc cccaagacag cagtcttctt     1740

cacccgctgc agccgttccg tcccaaacag agggccacac agatacccca cgttctatat     1800

aaggaggaaa acgggaaaga atataaagtt aaaaaaaagc ctccggtttc cactactgtg     1860

tagactcctg cttcttcaag cacctgcaga ttctgatttt tttgttgttg ttgttctcct     1920

ccattgctgt tgttgcaggg aagtcttact taaaaaaaaa aaaaaatttt gtgagtgact     1980

cggtgtaaaa ccatgtagtt ttaacagaac cagagggttg tactattgtt taaaaacagg     2040

aaaaaaaata atgtaagggt ctgttgtaaa tgaccaagaa aaagaaaaaa aaagcattcc     2100

caatcttgac acggtgaaat ccaggtctcg ggtccgatta atttatggtt tctgcgtgct     2160

ttatttatgg cttataaatg tgtattctgg ctgcaagggc cagagttcca caaatctata     2220

ttaaagtgtt atacccggtt ttatcccttg aatcttttct tccagatttt tcttttcttt     2280

acttggctta caaaatatac aggcttggaa attatttcaa gaaggaggga gggataccct     2340

gtctggttgc aggttgtatt ttattttggc ccagggagtg ttgctgtttt cccaacattt     2400

tattaataaa attttcagac ataaaaaa                                        2428


<210> 15
<211> 505
<212> PRT
<213> Homo sapiens

<400> 15
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile 
1               5                   10                  15      


Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro 
        35                  40                  45              


Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser 
    50                  55                  60                  


Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro 
65                  70                  75                  80  


Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser 
                85                  90                  95      


Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln 
            100                 105                 110         


Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr 
        115                 120                 125             


Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser 
    130                 135                 140                 


Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu 
145                 150                 155                 160 


His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser 
                165                 170                 175     


Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg 
            180                 185                 190         


Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg 
        195                 200                 205             


Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu 
    210                 215                 220                 


Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly 
225                 230                 235                 240 


Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe 
                245                 250                 255     


Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser 
            260                 265                 270         


Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser 
        275                 280                 285             


Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu 
    290                 295                 300                 


Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser 
305                 310                 315                 320 


Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly 
                325                 330                 335     


Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro 
            340                 345                 350         


Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala 
        355                 360                 365             


Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr 
    370                 375                 380                 


Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly 
385                 390                 395                 400 


Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro 
                405                 410                 415     


Lys Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser 
            420                 425                 430         


Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala 
        435                 440                 445             


Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp 
    450                 455                 460                 


Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu 
465                 470                 475                 480 


Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly 
                485                 490                 495     


Leu Asp Phe Asn Phe Glu Pro Asp Pro 
            500                 505 


<210> 16
<211> 3365
<212> DNA
<213> Homo sapiens

<400> 16
aaaaggggga gggaactgcg gctaaggaga cgttcggtga tgggagcgca atatatgagg       60

ggatacagtg cctcaggttt aaaagagcag gaagctgagt gagaggttgc agaaaaagtg      120

tcttcgctcg gcagaggtta caggtggcat ctcagaaaga gctttgaggc tacaggctgt      180

agtcgggaag gggatcggag aactgtgtga agggacagct tagggactag cgtcctggga      240

ctagggggaa gttcgcgact ttctgaagac tggcaggaat gtgcctcctg gccctcgatg      300

cttcccccct gaggggaggc atcgtgaggg actgtggcag gcttcactga acgctgagcc      360

ggggaggtcc aactccacgt atggatccgg ggaatgagaa ttcagccaca gaggctgccg      420

cgatcataga cctagatccc gacttcgaac cccagagccg tccccgctcc tgcacctggc      480

cccttccccg accagagatc gctaaccagc cgtccgagcc gcccgaggtg gagccagatc      540

tgggggaaaa ggtacacacg gaggggcgct cagagccgat cctgttgccc tctcggctcc      600

cagagccggc cgggggcccc cagcccggaa tcctgggggc tgtaacaggt cctcggaagg      660

gaggctcccg ccggaatgcc tggggaaatc agtcatatgc agaactcatc agccaggcca      720

ttgaaagcgc cccggagaag cgactgacac ttgcccagat ctacgagtgg atggtccgta      780

ctgtacccta cttcaaggac aagggtgaca gcaacagctc agcaggatgg aagaactcga      840

tccgccacaa cctgtccctg cacagcaagt tcatcaaggt tcacaacgag gccaccggca      900

aaagctcttg gtggatgctg aaccctgagg gaggcaagag cggcaaagcc ccccgccgcc      960

gggccgcctc catggatagc agcagcaagc tgctccgggg ccgcagtaaa gcccccaaga     1020

agaaaccatc tgtgctgcca gctccacccg aaggtgccac tccaacgagc cctgtcggcc     1080

actttgccaa gtggtcaggc agcccttgct ctcgaaaccg tgaagaagcc gatatgtgga     1140

ccaccttccg tccacgaagc agttcaaatg ccagcagtgt cagcacccgg ctgtccccct     1200

tgaggccaga gtctgaggtg ctggcggagg aaataccagc ttcagtcagc agttatgcag     1260

ggggtgtccc tcccaccctc aatgaaggtc tagagctgtt agatgggctc aatctcacct     1320

cttcccattc cctgctatct cggagtggtc tctctggctt ctctttgcag catcctgggg     1380

ttaccggccc cttacacacc tacagcagct cccttttcag cccagcagag gggcccctgt     1440

cagcaggaga agggtgcttc tccagctccc aggctctgga ggccctgctc acctctgata     1500

cgccaccacc ccctgctgac gtcctcatga cccaggtaga tcccattctg tcccaggctc     1560

cgactcttct gttgctgggg gggcttcctt cctccagtaa gctggccacg ggcgtcggcc     1620

tgtgtcccaa gcccctagag gctccaggcc ccagcagtct ggttcccacc ctttctatga     1680

tagcaccacc tccagtcatg gcaagtgccc ccatccccaa ggctctgggg actcctgtgc     1740

tcacaccccc tactgaagct gcaagccaag acagaatgcc tcaggatcta gatcttgata     1800

tgtatatgga gaacctggag tgtgacatgg ataacatcat cagtgacctc atggatgagg     1860

gcgagggact ggacttcaac tttgagccag atccctgagt catgcctgga agctttgtcc     1920

cctgcttcag atgtggagcc aggcgtgttc atatctactc tttacccttg agccctcccc     1980

aggaatttgg gaccctgctt tagagctagg gtggggtctg gtcacacaca ggtgttgaag     2040

aaattataaa gataaagctg ccccatctgg ggacgatatg gggagggaga tgggagggga     2100

aaggggagag ggtttttctc actgtgccaa ttagggggta aggccccctc tcaggagcca     2160

tcatcggctt tccccattcc tacccactta ggctttgtag caagatgagc aatgctgttg     2220

gaaatgtgaa gtcaccagtg gccttacccc tgcctttggg agcaggattt ttttgtagag     2280

agtcttatct gagctgagcc aggctagctg gagcctggga tttctatgca gtggcccctt     2340

aggccagtga tgtgcggtgg gtgggctgtt taggggatct ggaagggcca aggtctgagc     2400

actggagtgg ctcgccaggc caaatcaccc ttagaaggct gcagataaca gaaaggcttt     2460

ttataaactt ttaaagaaat ataaacacaa atatagagat tttttaacca tggcagggtg     2520

ctagtggtgg gcagaatgct tttttttctt tctgaaggct ttgtgatagt gacatgatac     2580

aaacactaca gacaataaat attaggagac acagggaagt ggggagaggt ggggagtaat     2640

agtaaacaca gggaagagct cccctacgga ccaggtatag agaaaggtct atgcagaaat     2700

aggttagagt ttccctaaca aaaaagctaa cccaggtccc ctcattcctt caacttgtgc     2760

ctgggagtgt gtggtgttag ggtgcagcca cactcttcta tgacccagca tgggttagtg     2820

ctatggtggg agagtacatt gaaggcctgg aattagcttg gggccaggga agggactggg     2880

aggggagaga agagaaggag ggaaggattt aggatggtaa agttaggtac agagacctcc     2940

ctgttcaagg cccctgacag ctgtccctgc ccttcttccc cttccctgac tgcaggggtt     3000

atgtggaagt gtgtgtggca gcaggcagcg gggaggggag gaacagggaa gggggagctg     3060

gggagcttgg ctgagggtct gggaaatgag cagggatggg gggggatgtg gatcaggttt     3120

actagcacct gccagggagg ccatctgggg ctccttctcc accccagccc ccaaagcagc     3180

ccttccccca gtgccctttg catcgtcccc tcccccaccc ctgctgtggg ttcccatcat     3240

ttcctgtgtc agcgcctggc ctacccagat tgtatcatgt gctagattgg agtggggaag     3300

tgtgtcaaat caataaatga ataaattcaa taaatgccta taaccagcaa aaaaaaaaaa     3360

aaaaa                                                                 3365


<210> 17
<211> 421
<212> PRT
<213> Homo sapiens

<400> 17
Met Asn Arg Gly Phe Ser Arg Lys Ser His Thr Phe Leu Pro Lys Ile 
1               5                   10                  15      


Phe Phe Arg Lys Met Ser Ser Ser Gly Ala Lys Asp Lys Pro Glu Leu 
            20                  25                  30          


Gln Phe Pro Phe Leu Gln Asp Glu Asp Thr Val Ala Thr Leu Leu Glu 
        35                  40                  45              


Cys Lys Thr Leu Phe Ile Leu Arg Gly Leu Pro Gly Ser Gly Lys Ser 
    50                  55                  60                  


Thr Leu Ala Arg Val Ile Val Asp Lys Tyr Arg Asp Gly Thr Lys Met 
65                  70                  75                  80  


Val Ser Ala Asp Ala Tyr Lys Ile Thr Pro Gly Ala Arg Gly Ala Phe 
                85                  90                  95      


Ser Glu Glu Tyr Lys Arg Leu Asp Glu Asp Leu Ala Ala Tyr Cys Arg 
            100                 105                 110         


Arg Arg Asp Ile Arg Ile Leu Val Leu Asp Asp Thr Asn His Glu Arg 
        115                 120                 125             


Glu Arg Leu Glu Gln Leu Phe Glu Met Ala Asp Gln Tyr Gln Tyr Gln 
    130                 135                 140                 


Val Val Leu Val Glu Pro Lys Thr Ala Trp Arg Leu Asp Cys Ala Gln 
145                 150                 155                 160 


Leu Lys Glu Lys Asn Gln Trp Gln Leu Ser Ala Asp Asp Leu Lys Lys 
                165                 170                 175     


Leu Lys Pro Gly Leu Glu Lys Asp Phe Leu Pro Leu Tyr Phe Gly Trp 
            180                 185                 190         


Phe Leu Thr Lys Lys Ser Ser Glu Thr Leu Arg Lys Ala Gly Gln Val 
        195                 200                 205             


Phe Leu Glu Glu Leu Gly Asn His Lys Ala Phe Lys Lys Glu Leu Arg 
    210                 215                 220                 


Gln Phe Val Pro Gly Asp Glu Pro Arg Glu Lys Met Asp Leu Val Thr 
225                 230                 235                 240 


Tyr Phe Gly Lys Arg Pro Pro Gly Val Leu His Cys Thr Thr Lys Phe 
                245                 250                 255     


Cys Asp Tyr Gly Lys Ala Pro Gly Ala Glu Glu Tyr Ala Gln Gln Asp 
            260                 265                 270         


Val Leu Lys Lys Ser Tyr Ser Lys Ala Phe Thr Leu Thr Ile Ser Ala 
        275                 280                 285             


Leu Phe Val Thr Pro Lys Thr Thr Gly Ala Arg Val Glu Leu Ser Glu 
    290                 295                 300                 


Gln Gln Leu Gln Leu Trp Pro Ser Asp Val Asp Lys Leu Ser Pro Thr 
305                 310                 315                 320 


Asp Asn Leu Pro Arg Gly Ser Arg Ala His Ile Thr Leu Gly Cys Ala 
                325                 330                 335     


Ala Asp Val Glu Ala Val Gln Thr Gly Leu Asp Leu Leu Glu Ile Leu 
            340                 345                 350         


Arg Gln Glu Lys Gly Gly Ser Arg Gly Glu Glu Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Gly Lys Leu Tyr Ser Leu Gly Asn Gly Arg Trp Met Leu Thr Leu 
    370                 375                 380                 


Ala Lys Asn Met Glu Val Arg Ala Ile Phe Thr Gly Tyr Tyr Gly Lys 
385                 390                 395                 400 


Gly Lys Pro Val Pro Thr Gln Gly Ser Arg Lys Gly Gly Ala Leu Gln 
                405                 410                 415     


Ser Cys Thr Ile Ile 
            420     


<210> 18
<211> 2598
<212> DNA
<213> Homo sapiens

<400> 18
ctccgcgcag gcgggcggcc ccggagcgct ggtgccggca gaggcggcga cggtggcgcc       60

cctcctcatc atgaggcttc tcccgaaaaa gccacacatt cctgcccaag atcttcttcc      120

gcaagatgtc atcctcaggg gccaaggaca agcctgagct gcagtttccc ttccttcagg      180

atgaggacac agtggccacg ctgctagagt gcaagacgct cttcatcttg cgcggcctgc      240

caggaagcgg caagtccacg ctggcacggg tcatcgtgga caagtaccgt gatggcacca      300

agatggtgtc ggctgacgct tacaagatca cccccggcgc tcgaggagcc ttctccgagg      360

agtacaagcg gctcgatgag gacctggctg cctactgccg ccgccgggac atcagaattc      420

ttgtgcttga tgacaccaac cacgaacggg aacggctgga gcagctcttt gaaatggccg      480

accagtacca gtaccaggtg gtgctggtgg agcccaagac ggcgtggcgg ctggactgtg      540

cccagctcaa ggagaagaac cagtggcagc tgtcggctga tgacctgaag aagctgaagc      600

ctgggctgga gaaggacttc ctgccgctct acttcggctg gttcctgacc aagaagagct      660

ctgagaccct ccgcaaagcc ggccaggtct tcctggaaga gctggggaac cacaaggcct      720

tcaagaagga gctgcgacaa ttcgtccctg gggatgagcc cagggagaag atggacttgg      780

tcacctactt tggaaagaga cccccaggcg tgctgcattg cacaaccaag ttttgtgact      840

acgggaaggc tcccggggca gaggagtacg ctcaacaaga tgtgttaaag aaatcttact      900

ccaaggcctt cacgctgacc atctctgccc tctttgtgac acccaagacg actggggccc      960

gggtggagtt aagcgagcag caactgcagt tgtggccgag tgatgtggac aagctgtcac     1020

ccactgacaa cctgccgcgg gggagccgcg cccacatcac cctcggctgt gcagctgacg     1080

tagaggccgt gcagacgggc cttgacctct tagagattct gcggcaggag aaggggggca     1140

gccgaggcga ggaggtgggc gagctaagcc ggggcaagct ctattccttg ggcaatgggc     1200

gctggatgct gaccctggcc aagaacatgg aggtcagggc catcttcacg gggtactacg     1260

ggaaaggcaa acctgtgccc acgcaaggta gccggaaggg gggcgccttg cagtcctgca     1320

ccatcatatg agtgttctca ccaccactta tgcccctaga agggaagggg agagggaaac     1380

gtgccctctg tttgatcctt gttttgtgac attttttttt tttttttttt tactcaaagt     1440

taacctacct gtaacttttt aaaaacttgt aaaataactg accctccctt cctgtccgcc     1500

ctcttcccct ctaatgctca cgctcccaac acaaggtggg cagggaggca ccattcagga     1560

acctggacca aagctgacga ggctgggcca agccagggat ggggccacag ccagaacccc     1620

gagccctact tccaggttct ggttagctca gccccagccc agcccagctg ctctgcccag     1680

agctgggtga gtggggagac acctcagagc cccgcaaaac ccactgaccg gaggcaaaag     1740

gcagtggggc tgggggtagt tttccatggt cacagagaac tagtggtggc tctgagaagg     1800

ggaggacctc tgggctttga ttccatctcc ttgtcttttt tctttgtttt tagagacagg     1860

gtcctgctat ttcccaagct ggagtgcagt ggtgcgatca tggctcactg cagcctcgaa     1920

ctcctgggct caagcaatcc tcctgagtga tcccatttct taatcagtgt agccccaaga     1980

aggctggggc tatttaccag ggtagaaaaa ggagcttacc tcccaccttt ggtcctaagt     2040

ccctgccccc tccccttcac accataacta ggtaacagtt tgataactag ggaagaaagc     2100

agaacagtta agcagccgcc acatccccgc tggctggggg cctcactcca ggaaggggct     2160

ggactggctg tcctttccag tggcctggct ccgctgtgtg gatggggaga tcggggccag     2220

aggcagaacc ctggtgagga agctccagtc ctgctctcta cccagcccat cttgcctcca     2280

tggtgcctct ggaggcctct gggcctcctc taacaggggc tggtgggcac caagagccaa     2340

tggagtagac ccctggctgg taagggccaa gtcccaccgg ttgcttctgg gaaggggttt     2400

ctaacactag tctgtgtgct gtggttcctg gggtgccctc cactgccctc tgttcagtaa     2460

cagggccttg ctaatcgggt tgtcactcaa caaaagtgct ttggatttaa gttactatcc     2520

tggctttgcc caacctcagc aacctgtaag actgataatg aaataaatca tgttaatcct     2580

agcaaaaaaa aaaaaaaa                                                   2598


<210> 19
<211> 304
<212> PRT
<213> Homo sapiens

<400> 19
Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210> 20
<211> 2139
<212> DNA
<213> Homo sapiens

<400> 20
gaaaacagtg cagccacctc cgagagcctg gatgtgatgg cgtcacagaa gagaccctcc       60

cagaggcacg gatccaagta cctggccaca gcaagtacca tggaccatgc caggcatggc      120

ttcctcccaa ggcacagaga cacgggcatc cttgactcca tcgggcgctt ctttggcggt      180

gacaggggtg cgccaaagcg gggctctggc aaggactcac accacccggc aagaactgct      240

cactatggct ccctgcccca gaagtcacac ggccggaccc aagatgaaaa ccccgtagtc      300

cacttcttca agaacattgt gacgcctcgc acaccacccc cgtcgcaggg aaaggggaga      360

ggactgtccc tgagcagatt tagctggggg gccgaaggcc agagaccagg atttggctac      420

ggaggcagag cgtccgacta taaatcggct cacaagggat tcaagggagt cgatgcccag      480

ggcacgcttt ccaaaatttt taagctggga ggaagagata gtcgctctgg atcacccatg      540

gctagacgct gaaaacccac ctggttccgg aatcctgtcc tcagcttctt aatataactg      600

ccttaaaact ttaatcccac ttgcccctgt tacctaatta gagcagatga cccctcccct      660

aatgcctgcg gagttgtgca cgtagtaggg tcaggccacg gcagcctacc ggcaatttcc      720

ggccaacagt taaatgagaa catgaaaaca gaaaacggtt aaaactgtcc ctttctgtgt      780

gaagatcacg ttccttcccc cgcaatgtgc ccccagacgc acgtgggtct tcagggggcc      840

aggtgcacag acgtccctcc acgttcaccc ctccaccctt ggactttctt ttcgccgtgg      900

ctcggcaccc ttgcgctttt gctggtcact gccatggagg cacacagctg cagagacaga      960

gaggacgtgg gcggcagaga ggactgttga catccaagct tcctttgttt ttttttcctg     1020

tccttctctc acctcctaaa gtagacttca tttttcctaa caggattaga cagtcaagga     1080

gtggcttact acatgtggga gctttttggt atgtgacatg cgggctgggc agctgttaga     1140

gtccaacgtg gggcagcaca gagagggggc cacctcccca ggccgtggct gcccacacac     1200

cccaattagc tgaattcgcg tgtggcagag ggaggaaaag gaggcaaacg tgggctgggc     1260

aatggcctca cataggaaac agggtcttcc tggagatttg gtgatggaga tgtcaagcag     1320

gtggcctctg gacgtcaccg ttgccctgca tggtggcccc agagcagcct ctatgaacaa     1380

cctcgtttcc aaaccacagc ccacagccgg agagtccagg aagacttgcg cactcagagc     1440

agaagggtag gagtcctcta gacagcctcg cagccgcgcc agtcgcccat agacactggc     1500

tgtgaccggg cgtgctggca gcggcagtgc acagtggcca gcactaaccc tccctgagaa     1560

gataaccggc tcattcactt cctcccagaa gacgcgtggt agcgagtagg cacaggcgtg     1620

cacctgctcc cgaattactc accgagacac acgggctgag cagacggccc ctgtgatgga     1680

gacaaagagc tcttctgacc atatccttct taacacccgc tggcatctcc tttcgcgcct     1740

ccctccctaa cctactgacc caccttttga ttttagcgca cctgtgattg ataggccttc     1800

caaagagtcc cacgctggca tcaccctccc cgaggacgga gatgaggagt agtcagcgtg     1860

atgccaaaac gcgtcttctt aatccaattc taattctgaa tgtttcgtgt gggcttaata     1920

ccatgtctat taatatatag cctcgatgat gagagagtta caaagaacaa aactccagac     1980

acaaacctcc aaatttttca gcagaagcac tctgcgtcgc tgagctgagg tcggctctgc     2040

gatccatacg tggccgcacc cacacagcac gtgctgtgac gatggctgaa cggaaagtgt     2100

acactgttcc tgaatattga aataaaacaa taaactttt                            2139


<210> 21
<211> 378
<212> PRT
<213> Homo sapiens

<400> 21
Met Asp Ser Val Arg Ser Gly Ala Phe Gly His Leu Phe Arg Pro Asp 
1               5                   10                  15      


Asn Phe Ile Phe Gly Gln Ser Gly Ala Gly Asn Asn Trp Ala Lys Gly 
            20                  25                  30          


His Tyr Thr Glu Gly Ala Glu Leu Val Asp Ser Val Leu Asp Val Val 
        35                  40                  45              


Arg Lys Glu Cys Glu Asn Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr 
    50                  55                  60                  


His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile 
65                  70                  75                  80  


Ser Lys Val Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Thr Phe Ser 
                85                  90                  95      


Val Val Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn 
            100                 105                 110         


Ala Thr Leu Ser Ile His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr 
        115                 120                 125             


Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys 
    130                 135                 140                 


Leu Ala Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr 
145                 150                 155                 160 


Met Ser Gly Val Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala 
                165                 170                 175     


Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His 
            180                 185                 190         


Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ala Arg Gly Ser Gln Gln 
        195                 200                 205             


Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala 
    210                 215                 220                 


Lys Asn Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr 
225                 230                 235                 240 


Val Ala Thr Val Phe Arg Gly Arg Met Ser Met Lys Glu Val Asp Glu 
                245                 250                 255     


Gln Met Leu Ala Ile Gln Ser Lys Asn Ser Ser Tyr Phe Val Glu Trp 
            260                 265                 270         


Ile Pro Asn Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly 
        275                 280                 285             


Leu Lys Met Ser Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu 
    290                 295                 300                 


Leu Phe Lys Arg Ile Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys 
305                 310                 315                 320 


Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe 
                325                 330                 335     


Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln 
            340                 345                 350         


Tyr Gln Asp Ala Thr Ala Glu Glu Glu Gly Glu Met Tyr Glu Asp Asp 
        355                 360                 365             


Glu Glu Glu Ser Glu Ala Gln Gly Pro Lys 
    370                 375             


<210> 22
<211> 1720
<212> DNA
<213> Homo sapiens

<400> 22
gcccggcccg cccgcgcccg tccgcagccg cccgccagac gcgcccagta tgagggagat       60

cgtgcacatc caggccggcc agtgcggcaa ccagatcggg gccaagttct gggaagtcat      120

cagtgatgag catggcatcg accccagcgg caactacgtg ggcgactcgg acttgcagct      180

ggagcggatc agcgtctact acaacgaggc ctcttctcac aagtacgtgc ctcgagccat      240

tctggtggac ctggaacccg gaaccatgga cagtgtccgc tcaggggcct ttggacatct      300

cttcaggcct gacaatttca tctttggtca gagtggggcc ggcaacaact gggccaaggg      360

tcactacacg gagggggcgg agctggtgga ttcggtcctg gatgtggtgc ggaaggagtg      420

tgaaaactgc gactgcctgc agggcttcca gctgacccac tcgctggggg gcggcacggg      480

ctccggcatg ggcacgttgc tcatcagcaa ggtgcgtgag gagtatcccg accgcatcat      540

gaacaccttc agcgtcgtgc cctcacccaa ggtgtcagac acggtggtgg agccctacaa      600

cgccacgctg tccatccacc agctggtgga gaacacggat gagacctact gcatcgacaa      660

cgaggcgctc tacgacatct gcttccgcac cctcaagctg gccacgccca cctacgggga      720

cctcaaccac ctggtatcgg ccaccatgag cggagtcacc acctccttgc gcttcccggg      780

ccagctcaac gctgacctgc gcaagctggc cgtcaacatg gtgcccttcc cgcgcctgca      840

cttcttcatg cccggcttcg cccccctcac agcccggggc agccagcagt accgggccct      900

gaccgtgccc gagctcaccc agcagatgtt cgatgccaag aacatgatgg ccgcctgcga      960

cccgcgccac ggccgctacc tgacggtggc caccgtgttc cggggccgca tgtccatgaa     1020

ggaggtggac gagcagatgc tggccatcca gagcaagaac agcagctact tcgtggagtg     1080

gatccccaac aacgtgaagg tggccgtgtg tgacatcccg ccccgcggcc tcaagatgtc     1140

ctccaccttc atcgggaaca gcacggccat ccaggagctg ttcaagcgca tctccgagca     1200

gttcacggcc atgttccggc gcaaggcctt cctgcactgg tacacgggcg agggcatgga     1260

cgagatggag ttcaccgagg ccgagagcaa catgaacgac ctggtgtccg agtaccagca     1320

gtaccaggac gccacggccg aggaagaggg cgagatgtac gaagacgacg aggaggagtc     1380

ggaggcccag ggccccaagt gaagctgctc gcagctggag tgagaggcag gtggcggccg     1440

gggccgaagc cagcagtgtc taaacccccg gagccatctt gctgccgaca ccctgctttc     1500

ccctcgccct agggctccct tgccgccctc ctgcagtatt tatggcctcg tcctccccac     1560

ctaggccacg tgtgagctgc tcctgtctct gtcttattgc agctccaggc ctgacgtttt     1620

acggttttgt tttttactgg tttgtgttta tattttcggg gatacttaat aaatctattg     1680

ctgtcagata cccttaaaaa aaaaaaaaaa aaaaaaaaaa                           1720


<210> 23
<211> 312
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Gln Pro Tyr Pro Pro Ala Gln Tyr Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Ala Glu Tyr Ala Pro Pro Pro Pro His Pro Thr Gln Asp 
            20                  25                  30          


Tyr Ser Gly Gln Thr Pro Val Pro Thr Glu His Gly Met Thr Leu Tyr 
        35                  40                  45              


Thr Pro Ala Gln Thr His Pro Glu Gln Pro Gly Ser Glu Ala Ser Thr 
    50                  55                  60                  


Gln Pro Ile Ala Gly Thr Gln Thr Val Pro Gln Thr Asp Glu Ala Ala 
65                  70                  75                  80  


Gln Thr Asp Ser Gln Pro Leu His Pro Ser Asp Pro Thr Glu Lys Gln 
                85                  90                  95      


Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp 
            100                 105                 110         


Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val 
        115                 120                 125             


Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr 
    130                 135                 140                 


Phe Glu Thr Ser Ser Asp Ala Asp Arg Ala Arg Glu Lys Leu Asn Gly 
145                 150                 155                 160 


Thr Ile Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg 
                165                 170                 175     


Val Met Thr Asn Lys Lys Thr Gly Asn Pro Tyr Thr Asn Gly Trp Lys 
            180                 185                 190         


Leu Asn Pro Val Val Gly Ala Val Tyr Gly Pro Glu Phe Tyr Ala Val 
        195                 200                 205             


Thr Gly Phe Pro Tyr Pro Thr Thr Gly Thr Ala Val Ala Tyr Arg Gly 
    210                 215                 220                 


Ala His Leu Arg Gly Arg Gly Arg Ala Val Tyr Asn Thr Phe Arg Ala 
225                 230                 235                 240 


Ala Pro Pro Pro Pro Pro Ile Pro Thr Tyr Gly Ala Val Val Tyr Gln 
                245                 250                 255     


Asp Gly Phe Tyr Gly Ala Glu Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg 
            260                 265                 270         


Tyr Ala Gln Pro Ala Ala Ala Ala Ala Ala Tyr Ser Asp Ser Tyr Gly 
        275                 280                 285             


Arg Val Tyr Ala Ala Ala Asp Pro Tyr His His Thr Ile Gly Pro Ala 
    290                 295                 300                 


Ala Thr Tyr Ser Ile Gly Thr Met 
305                 310         


<210> 24
<211> 3007
<212> DNA
<213> Homo sapiens

<400> 24
gatacagcag cagctggtgc tcctggccag gctgtgcgtg ctctctctgc ctctctctct       60

cggactctct gctctctctc tctgactctc tcctctctct ctgttggcct ggtgaaatgt      120

tcttggctgt aggcacacag agccttggac tcaaggctgt tggagtcgag gacaccttga      180

cttcggtcct ggaggttgaa attctgcctc tgagaagcta acagtcttcc tgtggtcgcc      240

actcctcccc agcagccccc tccttgccaa ggacggtcca gaaggagccc cactggggcc      300

tccccgctca gcaaagcaga cctcacctcc cactaccagc ttgaagtcac agcagccaga      360

ggaaattctg ccaccatttt cccaggtctg cagcccctcc agctgggaac ctgctcctgg      420

agccatccct ctgcaaacag agagcccaga gtgcctcggg gaaaattggc tgaataaaag      480

agcgatcagg acgccacggc tccgcctgaa gcgatggccc agccctaccc ccccgcccag      540

tacccccctc cgccacagaa cggcatccct gccgagtacg ccccgccccc accgcacccc      600

acgcaggact actccggcca gaccccggtc cccacagagc atggcatgac cctgtacaca      660

ccagcacaga cccaccccga gcagccaggc tccgaggcca gcacacagcc catcgccggg      720

acccagacag tgccgcagac agacgaggcg gcacagacgg acagccagcc gctccacccc      780

tccgacccta cagagaagca gcagcccaag cggctacacg tctccaacat ccccttccgg      840

ttcagggacc ccgacttgcg gcaaatgttc gggcaattcg gaaaaatttt agacgtggag      900

atcattttta acgagcgggg ctccaagggt tttgggtttg taacttttga aactagctca      960

gatgctgacc gagcccggga gaagctgaat gggacgatcg tagagggacg gaaaattgag     1020

gtcaataatg ccacggcccg agtgatgacc aacaagaaga cggggaaccc ctacaccaac     1080

ggctggaagc taaatccagt ggtcggcgca gtctacgggc ctgaattcta tgcagtgacg     1140

gggttcccct accccaccac cggcacagcc gttgcctacc ggggcgcaca tcttcggggc     1200

cggggccggg ccgtgtataa tacatttcgg gctgcgccac ccccaccccc catcccgact     1260

tacggagcgg tcgtgtatca ggatggattt tatggtgctg agatttatgg aggctacgca     1320

gcctacagat acgctcagcc cgctgcagcg gcggcagcct acagcgacag ttacggcaga     1380

gtctacgcag ctgccgaccc gtaccatcac accatcgggc ccgcggcgac ctacagcatt     1440

ggaaccatgt gaaaccttcc accgtttcct tctcggacca tgaagggcaa aaacaaaaaa     1500

acaaaaaaaa tcacaaaaca aaaaaaacaa aaaaagatgt taagatccaa gcaacaaaaa     1560

aaaaaccaac caaaccaaga ggcatccaac caagtccaag tcccgcgtcc tggccacacg     1620

cccgcaccga gggagcacgc cggcaggggc gccgaggagc ggccccagga caggacggcc     1680

ccaccgcgtc ctggctggca gcacagtggg aacacgcccc tccgtctcag gcagtggggg     1740

agttggaggg gaaggggcct cccttgtggg acccgtgggg ggctctgttt tccatccagt     1800

cttcctttcc cagcccccaa ctcccaagac agacagtgtg gagcccagcg gcggcggagc     1860

aggcccgggc ctgagcaggc aggcgctgct agcaagactt gatctttgtg gccagctgtg     1920

ccagggggcc ggcggggctg aggggtgcgg gcagctttca tcccaggggc tccactgggc     1980

cccgtcaccc tcctgtcgcg tcccctgcgt cccacctccc tcctgcccgg cagtcccgcc     2040

cgtgccccca gcctggcgag gaagccgtcc aacagtagcc ccggggccag ctcccaacag     2100

aaagggctga cgtggctcca ggactcaggg gcgctccatg ggaggacgaa ggaagcccag     2160

ccagccagga gccactcctc acacctccaa gtgtggccaa gtgggccctg aggccaagga     2220

cttacttgct cttcctggcc atctctccct ttctggagga ggcccggggc ctgtgtacac     2280

caaggctgac ctcgtgctgc ctgctgggac ccagccctcc ctgccgctcc cctgtgagcc     2340

cagtccaccg tgggcgccca gggccaggga cgggccagcg cccggctgca tcgcgaggtt     2400

gggagtcaca gtggctgtgg gcctggacgg gcacagccag agcaggggcc catgggaagg     2460

gcaagggatg gggaagcctg ggccggcccc ttccctgctc ccaaggcagg tgtccaggtg     2520

gcgggagcag caccaaggac agccaggctt acccggtggg aggagcagga gcagagcagg     2580

tggcagggag gaacccctgg cgaggcaggg agcactgaag tagggaagca gcaaaaaata     2640

caggctccca acgtggctcc actgtctcat gaagtgtcaa aaatttaaaa atacacctca     2700

ctttctattc agcatcagct attgaaatgg aattctcctt ttctattccc gttgtacata     2760

gccccacgcc ctgcctccgg ctttgtcctc tgtacagagc cccctgtccc ctctgctgtt     2820

ccggaccctt ttcttgcagc agctcaaccc cccgactcac tcagatcccc aggactgcag     2880

ccgagccccg ggcttccttt cttaccattc tgtatgcttc caaggtgtga ccattcaaac     2940

taacagtatt attaagatta ttaataaaga tttctttctt caaaccagga aaaaaaaaaa     3000

aaaaaaa                                                               3007


<210> 25
<211> 564
<212> PRT
<213> Homo sapiens

<400> 25
Met Ser Ser His Gly Asn Ser Leu Phe Leu Arg Glu Ser Gly Gln Arg 
1               5                   10                  15      


Leu Gly Arg Val Gly Trp Leu Gln Arg Leu Gln Glu Ser Leu Gln Gln 
            20                  25                  30          


Arg Ala Leu Arg Thr Arg Leu Arg Leu Gln Thr Met Thr Leu Glu His 
        35                  40                  45              


Val Leu Arg Phe Leu Arg Arg Asn Ala Phe Ile Leu Leu Thr Val Ser 
    50                  55                  60                  


Ala Val Val Ile Gly Val Ser Leu Ala Phe Ala Leu Arg Pro Tyr Gln 
65                  70                  75                  80  


Leu Thr Tyr Arg Gln Ile Lys Tyr Phe Ser Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Met Arg Met Leu Gln Met Leu Val Leu Pro Leu Ile Val Ser Ser Leu 
            100                 105                 110         


Val Thr Gly Met Ala Ser Leu Asp Asn Lys Ala Thr Gly Arg Met Gly 
        115                 120                 125             


Met Arg Ala Ala Val Tyr Tyr Met Val Thr Thr Ile Ile Ala Val Phe 
    130                 135                 140                 


Ile Gly Ile Leu Met Val Thr Ile Ile His Pro Gly Lys Gly Ser Lys 
145                 150                 155                 160 


Glu Gly Leu His Arg Glu Gly Arg Ile Glu Thr Ile Pro Thr Ala Asp 
                165                 170                 175     


Ala Phe Met Asp Leu Ile Arg Asn Met Phe Pro Pro Asn Leu Val Glu 
            180                 185                 190         


Ala Cys Phe Lys Gln Phe Lys Thr Gln Tyr Ser Thr Arg Val Val Thr 
        195                 200                 205             


Arg Thr Met Val Arg Thr Glu Asn Gly Ser Glu Pro Gly Ala Ser Met 
    210                 215                 220                 


Pro Pro Pro Phe Ser Val Glu Asn Gly Thr Ser Phe Leu Glu Asn Val 
225                 230                 235                 240 


Thr Arg Ala Leu Gly Thr Leu Gln Glu Met Leu Ser Phe Glu Glu Thr 
                245                 250                 255     


Val Pro Val Pro Gly Ser Ala Asn Gly Ile Asn Ala Leu Gly Leu Val 
            260                 265                 270         


Val Phe Ser Val Ala Phe Gly Leu Val Ile Gly Gly Met Lys His Lys 
        275                 280                 285             


Gly Arg Val Leu Arg Asp Phe Phe Asp Ser Leu Asn Glu Ala Ile Met 
    290                 295                 300                 


Arg Leu Val Gly Ile Ile Ile Trp Tyr Ala Pro Val Gly Ile Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Gly Lys Ile Leu Glu Met Glu Asp Met Ala Val Leu Gly 
                325                 330                 335     


Gly Gln Leu Gly Met Tyr Thr Leu Thr Val Ile Val Gly Leu Phe Leu 
            340                 345                 350         


His Ala Gly Ile Val Leu Pro Leu Ile Tyr Phe Leu Val Thr His Arg 
        355                 360                 365             


Asn Pro Phe Pro Phe Ile Gly Gly Met Leu Gln Ala Leu Ile Thr Ala 
    370                 375                 380                 


Met Gly Thr Ser Ser Ser Ser Ala Thr Leu Pro Ile Thr Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Glu Gly Leu Gly Val Asp Arg Arg Ile Thr Arg Phe Val Leu 
                405                 410                 415     


Pro Val Gly Ala Thr Val Asn Met Asp Gly Thr Ala Leu Tyr Glu Ala 
            420                 425                 430         


Leu Ala Ala Ile Phe Ile Ala Gln Val Asn Asn Tyr Glu Leu Asn Leu 
        435                 440                 445             


Gly Gln Ile Thr Thr Ile Ser Ile Thr Ala Thr Ala Ala Ser Val Gly 
    450                 455                 460                 


Ala Ala Gly Ile Pro Gln Ala Gly Leu Val Thr Met Val Ile Val Leu 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Thr Glu Asp Ile Thr Leu Ile Ile Ala Val 
                485                 490                 495     


Asp Trp Phe Leu Asp Arg Leu Arg Thr Met Thr Asn Val Leu Gly Asp 
            500                 505                 510         


Ser Ile Gly Ala Ala Val Ile Glu His Leu Ser Gln Arg Glu Leu Glu 
        515                 520                 525             


Leu Gln Glu Ala Glu Leu Thr Leu Pro Ser Leu Gly Lys Pro Tyr Lys 
    530                 535                 540                 


Ser Leu Met Ala Gln Glu Lys Gly Ala Ser Arg Gly Arg Gly Gly Asn 
545                 550                 555                 560 


Glu Ser Ala Met 
                


<210> 26
<211> 2990
<212> DNA
<213> Homo sapiens

<400> 26
ggcatagcgc gtcccggctc cgcgccggtg cctccacggt ccggtccccg cgccggtgct       60

gcacagtccc tggcgggtcc ccgcggcccc ggccgggcgc ttcgccgggc tccggctcct      120

gcatccgggc gcagcgcgca ggccgaggcg cgggcaggcc gcccccgccg ctccggacgc      180

cgggatgtaa gaggctccga aaagcagccc acgcatctca tcagatctaa gtgtctagag      240

gtcgggagaa ccaagtggga aagacccacc ctcacccctc accttgtaga aactgggaac      300

actagaaggg acattttctg agcaggaaac ccaagagaca gggttttacg ctgtcaccca      360

agttggagtg cagtggtacg atcatagctc attgcagcct caaactcctg ggttcaagcg      420

atcctcctgc tttagcctct tgagtagcta ggactacagg cacaggccac cgtgcctggc      480

taatttttaa tttttaaaaa agagacaggg tctggctatg ttgcccaggc tggccatgaa      540

ctcctgggct caagcggttc tccagccttc acctcccaaa gtgttgggat tgcaggcatg      600

agccactgcg tctggcccac agatgctaag tgctgtctgc tcttctccag gggtcagcaa      660

attttttcag caaatggccc aagagtaaat attttgagct ttgtggcccg tacaatctct      720

gtcccaacaa ctcaactcag gcattgtagc ttgaaagcag ctgtagacaa taggtaatcc      780

atgagtgtgg ctgtgtgcca ataaaacttt atttacaaaa acaagcagta ggctgaattt      840

gactagcaga ccatagtttg tcaataccgt attatgtctt gtaaggaaga gaaaggaacc      900

agacaaaact ctagcctcgg gagttttcct gactgttcag atcttagctg aatgatctcc      960

cttggtatct acaggcaact tcctgctgtg gcttagggac tggaaacata atatcccaga     1020

gggattccct gtgtagtctg tggttcactc tttgggattt tttttttttt tttcacagca     1080

aggagaagca gcattgtggt ttcaggagat gggtccattt ggagcaggat cctaagtggg     1140

gcttggcatt gggaatttgg attagctcta gaggacgcag gatctggaaa atcagggcag     1200

atttcccatc ccttggatat ggtggggagt tgaggagggc aaggaagatc ccagaaaagc     1260

cagtggcagc aaaacacaaa ggccagggac ctacgtactg gtaaaactga gacctccaag     1320

aaacctgcag ctcgacctgg ttgaattcag atagaccatg agcagccatg gcaacagcct     1380

gttccttcgg gagagcggcc agcggctggg ccgggtgggc tggctgcagc ggctgcagga     1440

aagcctgcag cagagagcac tgcgcacgcg cctgcgcctg cagaccatga ccctcgagca     1500

cgtgctgcgc ttcctgcgcc gaaacgcctt cattctgctg acggtcagcg ccgtggtcat     1560

tggggtcagc ctggcctttg ccctgcgccc atatcagctc acctaccgcc agatcaagta     1620

cttctctttt cctggagagc ttctgatgag gatgctgcag atgctggtgt tacctctcat     1680

tgtctccagc ctggtcacag gtatggcatc cctggacaac aaggccacgg ggcggatggg     1740

gatgcgggca gctgtgtact acatggtgac caccatcatc gcggtcttca tcggcatcct     1800

catggtcacc atcatccatc ccgggaaggg ctccaaggag gggctgcacc gggagggccg     1860

gatcgagacc atccccacag ctgatgcctt catggacctg atcagaaata tgtttccacc     1920

aaaccttgtg gaggcctgct tcaaacagtt caagacgcag tacagcacga gggtggtaac     1980

caggaccatg gtgaggacag agaacgggtc tgagccgggt gcctccatgc ctcctccatt     2040

ctcagtggag aacggaacca gcttcctgga aaatgtcact cgggccttgg gtaccctgca     2100

ggagatgctg agctttgagg agactgtacc cgtgcctggc tccgccaatg gcatcaacgc     2160

cctgggcctc gtggtcttct ctgtggcctt tgggctggtc attggtggca tgaaacacaa     2220

gggcagagtc ctcagggact tcttcgacag cctcaatgag gctattatga ggctggtggg     2280

catcattatc tggtgagtcc tggtctgtgc ccacgggaag gtggagccag agctgggaag     2340

tcaggctgtg gggaagctgc cgaagggctt gctggggacc tttggtcatt catttacgta     2400

ttgggtgatt cacttaccca ctcaccaact cattcattca tgtctttctg ggatgatttc     2460

atcactagtt cacttccttg ttcatctgtt cattcattca ttcttctatg cattggttag     2520

ttcatggaat atctcactct ttcattcatt catgtccttc tgcaatgatt cattcactgc     2580

tttgttcatc tgttcattca ctcattcttc tatgcattga tgaaatcact cattcagtga     2640

tttattcatc tatactcatg cttcaatgca ttgatttact catttcctca tgcatttatt     2700

cattcatcta tgcattggtt aaatcactgg ccaactcact aactcattca ttcattcaca     2760

cttttctgca atgatttgtt cacttgttca ctcccttgct tatctgttca ttcactcatt     2820

cttcaataca ttgaccaagc cattcactga catttattca gctacattta ttctttcatg     2880

cattggtctg gatttatttg gtcattcatt tatttatttt gcaaaattaa tgtattttta     2940

attgacaaat aaaaactgta tatattttca tgtgcaaaaa aaaaaaaaaa                2990


<210> 27
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu 
            180                 185                 190         


Pro Ala Ala Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp 
        195                 200                 205             


Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe 
    210                 215                 220                 


Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
225                 230                 235                 240 


Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser 
                245                 250                 255     


Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala 
            260                 265                 270         


Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp 
        275                 280                 285             


Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
    290                 295                 300                 


Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg 
305                 310                 315                 320 


Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser 
                325                 330                 335     


Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys 
            340                 345                 350         


Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser 
        355                 360                 365             


Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr 
    370                 375                 380                 


Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys 
385                 390                 395                 400 


Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu 
                405                 410                 415     


Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr 
            420                 425                 430         


Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro 
        435                 440                 445             


Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys 
    450                 455                 460                 


Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe 
465                 470                 475                 480 


Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys 
                485                 490                 495     


Ile Glu Glu Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr 
            500                 505                 510         


Lys Thr Ser Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp 
        515                 520                 525             


Tyr Val Thr Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala 
    530                 535                 540                 


Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu 
545                 550                 555                 560 


Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys 
                565                 570                 575     


Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro 
            580                 585                 590         


Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser 
        595                 600                 605             


Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val 
    610                 615                 620                 


Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu 
625                 630                 635                 640 


Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro 
                645                 650                 655     


Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly 
            660                 665                 670         


Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln 
        675                 680                 685             


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
    690                 695                 700                 


Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu 
705                 710                 715                 720 


Met Ala Lys Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu 
                725                 730                 735     


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
            740                 745                 750         


Ile Pro Asp Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys 
        755                 760                 765             


Glu Ser Leu Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu 
785                 790                 795                 800 


Glu Ser Phe Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro 
                805                 810                 815     


Asp Glu Val Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met 
            820                 825                 830         


Glu Glu Leu Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser 
        835                 840                 845             


Lys Glu Ala Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro 
    850                 855                 860                 


Ile Glu Ile Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp 
865                 870                 875                 880 


Ser Phe Ser Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His 
                885                 890                 895     


Lys Ser Glu Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys 
            900                 905                 910         


Thr Glu Leu Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val 
        915                 920                 925             


Glu Glu Lys Ile Ser Phe Ser Asp Asp Phe Ser Lys Asn Gly Ser Ala 
    930                 935                 940                 


Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val Ser Ala Leu Ala Thr 
945                 950                 955                 960 


Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys Val Leu Val Lys Glu 
                965                 970                 975     


Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp Arg Ser Pro 
            980                 985                 990         


Ser Ala Ile Phe Ser Ala Glu Leu  Ser Lys Thr Ser Val  Val Asp Leu 
        995                 1000                 1005             


Leu Tyr  Trp Arg Asp Ile Lys  Lys Thr Gly Val Val  Phe Gly Ala 
    1010                 1015                 1020             


Ser Leu  Phe Leu Leu Leu Ser  Leu Thr Val Phe Ser  Ile Val Ser 
    1025                 1030                 1035             


Val Thr  Ala Tyr Ile Ala Leu  Ala Leu Leu Ser Val  Thr Ile Ser 
    1040                 1045                 1050             


Phe Arg  Ile Tyr Lys Gly Val  Ile Gln Ala Ile Gln  Lys Ser Asp 
    1055                 1060                 1065             


Glu Gly  His Pro Phe Arg Ala  Tyr Leu Glu Ser Glu  Val Ala Ile 
    1070                 1075                 1080             


Ser Glu  Glu Leu Val Gln Lys  Tyr Ser Asn Ser Ala  Leu Gly His 
    1085                 1090                 1095             


Val Asn  Cys Thr Ile Lys Glu  Leu Arg Arg Leu Phe  Leu Val Asp 
    1100                 1105                 1110             


Asp Leu  Val Asp Ser Leu Lys  Phe Ala Val Leu Met  Trp Val Phe 
    1115                 1120                 1125             


Thr Tyr  Val Gly Ala Leu Phe  Asn Gly Leu Thr Leu  Leu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Ile Ser Leu Phe Ser  Val Pro Val Ile Tyr  Glu Arg His 
    1145                 1150                 1155             


Gln Ala  Gln Ile Asp His Tyr  Leu Gly Leu Ala Asn  Lys Asn Val 
    1160                 1165                 1170             


Lys Asp  Ala Met Ala Lys Ile  Gln Ala Lys Ile Pro  Gly Leu Lys 
    1175                 1180                 1185             


Arg Lys  Ala Glu 
    1190         


<210> 28
<211> 4871
<212> DNA
<213> Homo sapiens

<400> 28
agtccctgcc ctcccctggg gagggtgagt cacgccaaac tgggcggaga gtccgctggc       60

ctcactccta gctcatctgg gcggcggcgg caagtgggga cagggcgggt ggcgcatcac      120

cggcgcggag gcaggaggag cagtctcatt gttccgggag ccgtcaccac agtaggtccc      180

tcggctcagt cggcccagcc cctctcagtc ctccccaacc cccacaaccg cccgcggctc      240

tgagacgcgg ccccggcggc ggcggcagca gctgcagcat catctccacc ctccagccat      300

ggaagacctg gaccagtctc ctctggtctc gtcctcggac agcccacccc ggccgcagcc      360

cgcgttcaag taccagttcg tgagggagcc cgaggacgag gaggaagaag aggaggagga      420

agaggaggac gaggacgaag acctggagga gctggaggtg ctggagagga agcccgccgc      480

cgggctgtcc gcggccccag tgcccaccgc ccctgccgcc ggcgcgcccc tgatggactt      540

cggaaatgac ttcgtgccgc cggcgccccg gggacccctg ccggccgctc cccccgtcgc      600

cccggagcgg cagccgtctt gggacccgag cccggtgtcg tcgaccgtgc ccgcgccatc      660

cccgctgtct gctgccgcag tctcgccctc caagctccct gaggacgacg agcctccggc      720

ccggcctccc cctcctcccc cggccagcgt gagcccccag gcagagcccg tgtggacccc      780

gccagccccg gctcccgccg cgcccccctc caccccggcc gcgcccaagc gcaggggctc      840

ctcgggctca gtggatgaga ccctttttgc tcttcctgct gcatctgagc ctgtgatacg      900

ctcctctgca gaaaatatgg acttgaagga gcagccaggt aacactattt cggctggtca      960

agaggatttc ccatctgtcc tgcttgaaac tgctgcttct cttccttctc tgtctcctct     1020

ctcagccgct tctttcaaag aacatgaata ccttggtaat ttgtcaacag tattacccac     1080

tgaaggaaca cttcaagaaa atgtcagtga agcttctaaa gaggtctcag agaaggcaaa     1140

aactctactc atagatagag atttaacaga gttttcagaa ttagaatact cagaaatggg     1200

atcatcgttc agtgtctctc caaaagcaga atctgccgta atagtagcaa atcctaggga     1260

agaaataatc gtgaaaaata aagatgaaga agagaagtta gttagtaata acatccttca     1320

taatcaacaa gagttaccta cagctcttac taaattggtt aaagaggatg aagttgtgtc     1380

ttcagaaaaa gcaaaagaca gttttaatga aaagagagtt gcagtggaag ctcctatgag     1440

ggaggaatat gcagacttca aaccatttga gcgagtatgg gaagtgaaag atagtaagga     1500

agatagtgat atgttggctg ctggaggtaa aatcgagagc aacttggaaa gtaaagtgga     1560

taaaaaatgt tttgcagata gccttgagca aactaatcac gaaaaagata gtgagagtag     1620

taatgatgat acttctttcc ccagtacgcc agaaggtata aaggatcgtt caggagcata     1680

tatcacatgt gctcccttta acccagcagc aactgagagc attgcaacaa acatttttcc     1740

tttgttagga gatcctactt cagaaaataa gaccgatgaa aaaaaaatag aagaaaagaa     1800

ggcccaaata gtaacagaga agaatactag caccaaaaca tcaaaccctt ttcttgtagc     1860

agcacaggat tctgagacag attatgtcac aacagataat ttaacaaagg tgactgagga     1920

agtcgtggca aacatgcctg aaggcctgac tccagattta gtacaggaag catgtgaaag     1980

tgaattgaat gaagttactg gtacaaagat tgcttatgaa acaaaaatgg acttggttca     2040

aacatcagaa gttatgcaag agtcactcta tcctgcagca cagctttgcc catcatttga     2100

agagtcagaa gctactcctt caccagtttt gcctgacatt gttatggaag caccattgaa     2160

ttctgcagtt cctagtgctg gtgcttccgt gatacagccc agctcatcac cattagaagc     2220

ttcttcagtt aattatgaaa gcataaaaca tgagcctgaa aaccccccac catatgaaga     2280

ggccatgagt gtatcactaa aaaaagtatc aggaataaag gaagaaatta aagagcctga     2340

aaatattaat gcagctcttc aagaaacaga agctccttat atatctattg catgtgattt     2400

aattaaagaa acaaagcttt ctgctgaacc agctccggat ttctctgatt attcagaaat     2460

ggcaaaagtt gaacagccag tgcctgatca ttctgagcta gttgaagatt cctcacctga     2520

ttctgaacca gttgacttat ttagtgatga ttcaatacct gacgttccac aaaaacaaga     2580

tgaaactgtg atgcttgtga aagaaagtct cactgagact tcatttgagt caatgataga     2640

atatgaaaat aaggaaaaac tcagtgcttt gccacctgag ggaggaaagc catatttgga     2700

atcttttaag ctcagtttag ataacacaaa agataccctg ttacctgatg aagtttcaac     2760

attgagcaaa aaggagaaaa ttcctttgca gatggaggag ctcagtactg cagtttattc     2820

aaatgatgac ttatttattt ctaaggaagc acagataaga gaaactgaaa cgttttcaga     2880

ttcatctcca attgaaatta tagatgagtt ccctacattg atcagttcta aaactgattc     2940

attttctaaa ttagccaggg aatatactga cctagaagta tcccacaaaa gtgaaattgc     3000

taatgccccg gatggagctg ggtcattgcc ttgcacagaa ttgccccatg acctttcttt     3060

gaagaacata caacccaaag ttgaagagaa aatcagtttc tcagatgact tttctaaaaa     3120

tgggtctgct acatcaaagg tgctcttatt gcctccagat gtttctgctt tggccactca     3180

agcagagata gagagcatag ttaaacccaa agttcttgtg aaagaagctg agaaaaaact     3240

tccttccgat acagaaaaag aggacagatc accatctgct atattttcag cagagctgag     3300

taaaacttca gttgttgacc tcctgtactg gagagacatt aagaagactg gagtggtgtt     3360

tggtgccagc ctattcctgc tgctttcatt gacagtattc agcattgtga gcgtaacagc     3420

ctacattgcc ttggccctgc tctctgtgac catcagcttt aggatataca agggtgtgat     3480

ccaagctatc cagaaatcag atgaaggcca cccattcagg gcatatctgg aatctgaagt     3540

tgctatatct gaggagttgg ttcagaagta cagtaattct gctcttggtc atgtgaactg     3600

cacgataaag gaactcaggc gcctcttctt agttgatgat ttagttgatt ctctgaagtt     3660

tgcagtgttg atgtgggtat ttacctatgt tggtgccttg tttaatggtc tgacactact     3720

gattttggct ctcatttcac tcttcagtgt tcctgttatt tatgaacggc atcaggcaca     3780

gatagatcat tatctaggac ttgcaaataa gaatgttaaa gatgctatgg ctaaaatcca     3840

agcaaaaatc cctggattga agcgcaaagc tgaatgaaaa cgcccaaaat aattagtagg     3900

agttcatctt taaaggggat attcatttga ttatacgggg gagggtcagg gaagaacgaa     3960

ccttgacgtt gcagtgcagt ttcacagatc gttgttagat ctttattttt agccatgcac     4020

tgttgtgagg aaaaattacc tgtcttgact gccatgtgtt catcatctta agtattgtaa     4080

gctgctatgt atggatttaa accgtaatca tatctttttc ctatctatct gaggcactgg     4140

tggaataaaa aacctgtata ttttactttg ttgcagatag tcttgccgca tcttggcaag     4200

ttgcagagat ggtggagcta gaaaaaaaaa aaaaaaagcc cttttcagtt tgtgcactgt     4260

gtatggtccg tgtagattga tgcagatttt ctgaaatgaa atgtttgttt agacgagatc     4320

ataccggtaa agcaggaatg acaaagcttg cttttctggt atgttctagg tgtattgtga     4380

cttttactgt tatattaatt gccaatataa gtaaatatag attatatatg tatagtgttt     4440

cacaaagctt agacctttac cttccagcca ccccacagtg cttgatattt cagagtcagt     4500

cattggttat acatgtgtag ttccaaagca cataagctag aagaagaaat atttctagga     4560

gcactaccat ctgttttcaa catgaaatgc cacacacata gaactccaac atcaatttca     4620

ttgcacagac tgactgtagt taattttgtc acagaatcta tggactgaat ctaatgcttc     4680

caaaaatgtt gtttgtttgc aaatatcaaa cattgttatg caagaaatta ttaattacaa     4740

aatgaagatt tataccattg tggtttaagc tgtactgaac taaatctgtg gaatgcattg     4800

tgaactgtaa aagcaaagta tcaataaagc ttatagactt aaaaaaaaaa aaaaaaaaaa     4860

aaaaaaaaaa a                                                          4871


<210> 29
<211> 271
<212> PRT
<213> Homo sapiens

<400> 29
Met Tyr Tyr Ala Val Ser Gln Ala Arg Val Asn Ala Val Pro Gly Thr 
1               5                   10                  15      


Met Leu Arg Pro Gln Arg Pro Gly Asp Leu Gln Leu Gly Ala Ser Leu 
            20                  25                  30          


Tyr Glu Leu Val Gly Tyr Arg Gln Pro Pro Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Thr Ser Ser Thr Ser Ser Thr Ser Ser Ser Ser Thr Thr Ala Pro Leu 
    50                  55                  60                  


Leu Pro Lys Ala Ala Arg Glu Lys Pro Glu Ala Pro Ala Glu Pro Pro 
65                  70                  75                  80  


Gly Pro Gly Pro Gly Ser Gly Ala His Pro Gly Gly Ser Ala Arg Pro 
                85                  90                  95      


Asp Ala Lys Glu Glu Gln Gln Gln Gln Leu Arg Arg Lys Ile Asn Ser 
            100                 105                 110         


Arg Glu Arg Lys Arg Met Gln Asp Leu Asn Leu Ala Met Asp Ala Leu 
        115                 120                 125             


Arg Glu Val Ile Leu Pro Tyr Ser Ala Ala His Cys Gln Gly Ala Pro 
    130                 135                 140                 


Gly Arg Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr 
145                 150                 155                 160 


Ile Leu Leu Leu Gly Ser Ser Leu Gln Glu Leu Arg Arg Ala Leu Gly 
                165                 170                 175     


Glu Gly Ala Gly Pro Ala Ala Pro Arg Leu Leu Leu Ala Gly Leu Pro 
            180                 185                 190         


Leu Leu Ala Ala Ala Pro Gly Ser Val Leu Leu Ala Pro Gly Ala Val 
        195                 200                 205             


Gly Pro Pro Asp Ala Leu Arg Pro Ala Lys Tyr Leu Ser Leu Ala Leu 
    210                 215                 220                 


Asp Glu Pro Pro Cys Gly Gln Phe Ala Leu Pro Gly Gly Gly Ala Gly 
225                 230                 235                 240 


Gly Pro Gly Leu Cys Thr Cys Ala Val Cys Lys Phe Pro His Leu Val 
                245                 250                 255     


Pro Ala Ser Leu Gly Leu Ala Ala Val Gln Ala Gln Phe Ser Lys 
            260                 265                 270     


<210> 30
<211> 2298
<212> DNA
<213> Homo sapiens

<400> 30
gttctagatc gtttccccgc gcgcaggtcc gcggggaggg gcggcctgcc gaccggccca       60

ccccagggcg ttcctgaagg gcgtcctcgg ccgcccccac cgcctcccag atgtactatg      120

cggtttccca ggcgcgcgtg aacgcggtcc ccgggaccat gctgcggcca cagcggcccg      180

gagacttgca gctcggggcc tccctctacg agctggtggg ctacaggcag ccgccctcct      240

cctcctcctc ctccacctcc tccacctcct ccacttcctc ctcctccacg acggcccccc      300

tcctccccaa ggctgcgcgc gagaagccgg aggcgccggc cgagcctcca ggccccgggc      360

ccgggtcagg cgcgcacccg ggcggcagcg cccggccgga cgccaaggag gagcagcagc      420

agcagctgcg gcgcaagatc aacagccgcg agcggaagcg catgcaggac ctgaacctgg      480

ccatggacgc cctgcgcgag gtcatcctgc cctactcagc ggcgcactgc cagggcgcgc      540

ccggccgcaa gctctccaag atagccacgc tgctgctcgc ccgcaactac atcctactgc      600

tgggcagctc gctgcaggag ctgcgccgcg cgctgggcga gggcgccggg cccgccgcgc      660

cgcgcctgct gctggccggg ctgcccctgc tcgccgccgc gcccggctcc gtgctgctgg      720

cgcccggcgc cgtaggaccc cccgacgcgc tgcgccccgc caagtacctg tcgctggcgc      780

tggacgagcc gccgtgcggc cagttcgctc tccccggcgg cggcgcaggc ggccccggcc      840

tctgcacctg cgccgtgtgc aagttcccgc acctggtccc ggccagcctg ggcctggccg      900

ccgtgcaggc gcaattctcc aagtgagggc gggtctgggc ctggggcgcg acctcggccc      960

ggcctccctt cgctcagctt ctccgcgccc ctgctccctg cgtctgggag agcgaggccg     1020

agcaaggaaa gcatttcgaa ccttccagtc cagaggaagg gactgtcggg cacccccttc     1080

cccgccccca cccctgggac gttaaagtga ccagagcgga tgttcgatgg cgcctcgggg     1140

cagtttgggg ttctgggtcg gttccagcgg ctttaggcag aaagtgctcg ctctcaccca     1200

gcacatctct ctccttgtcc ctggagttgc gcgcttcgcg gggccgatgt agaacttagg     1260

gcgccttgcc gtggttggcg cgccccgggt gcagcgagag gccatccccg agcgctacct     1320

ccccggagcg gagcacgcgg gctcccagta ctaggggctg cgctcgagca gtggcggggg     1380

cggaggggtg gttcttttcc ttctcctccg ccagaggcca cgggcgccct tgttcccgcc     1440

ggccaggtcc tatcaaagga ggctgccgga actcaagagg cagaaaaaga ccagttaggc     1500

ggtgcagacg gtctgggacg tggcagacgg acggaccctc ggcggacagg tggtcggcgt     1560

cggggtgcgg tgggtagggg cgaggacaac gcagggtgcg ctgggttggg acgtgggtcc     1620

acttttgtag accagctgtt tggagagctg tatttaagac tcgcgtatcc agtgttttgt     1680

cgcagagagt tttcactctt aaatcctggg ggtttcttag aaagcaactt agaactcgag     1740

attcaccttt cgtttccctt tccccaaaag tagcgtaacc aacatttaag cttgcttaaa     1800

aacgaaaacc aaccgccttg catccagtgt tcccgattta ctaaaatagg taaccaggcg     1860

tctcacagtc gccgtcctgt caagagcgct aatgaacgtt ctcattaaca cgcaggagta     1920

ccgggagccc tgaaccgccc gctgctcggc ggatcccagc tgcggtggcg acggcgggaa     1980

ggcgctttcc gctgttcctc agcgggccgg gcccttgacc agcgcggccc gcaggtcttc     2040

cttctcgccg tcttgcagtt gaagagctac atacgtagtc agtttcgatt tgttacagac     2100

gttaacaaat tcctttaccc aaggttatgc tatgaccttt ccgcagttta ctttgatttt     2160

ctatgtttaa ggttttggtt gttggtagta gccgaattta actggcactt tattttactt     2220

ctaaccttgt ttcctgacgg tgtacagaat caacaaaata aaacatttaa agtctgattt     2280

tttaaaaaaa aaaaaaaa                                                   2298


<210> 31
<211> 323
<212> PRT
<213> Homo sapiens

<400> 31
Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Leu Gln Gln Leu Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210> 32
<211> 3275
<212> DNA
<213> Homo sapiens

<400> 32
gggtgcttat tatagatcga cgcgacacca gcgcccggtg ccaggttctc ccctgaggct       60

tttcggagcg agctcctcaa atcgcatcca gagtaagtgt ccccgcccca cagcagccgc      120

agcctagatc ccagggacag actctcctca actcggctgt gacccagaat gctccgatac      180

agggggtctg gatccctact ctgcgggcca tttctccaga gcgactttgc tcttctgtcc      240

tccccacact caccgctgca tctccctcac caaaagcgag aagtcggagc gacaacagct      300

ctttctgccc aagccccagt cagctggtga gctccccgtg gtctccagat gcagcacatg      360

gactctgggc cccgcgccgg ctctgggtgc atgtgcgtgt gcgtgtgttt gctgcgtggt      420

gtcgatggag ataaggtgga tccgtttgag gaaccaaatc attagttctc tatttagatc      480

tccattctcc ccaaagaaag gccctcactt cccactcgtt tattccagcc cgggggctca      540

gttttcccac acctaactga aagcccgaag cctctagaat gccacccgca ccccgagggt      600

caccaacgct ccctgaaata acctgttgca tgagagcaga ggggagatag agagagctta      660

attataggta cccgcgtgca gctaaaagga gggccagaga tagtagcgag ggggacgagg      720

agccacgggc cacctgtgcc gggaccccgc gctgtggtac tgcggtgcag gcgggagcag      780

cttttctgtc tctcactgac tcactctctc tctctctccc tctctctctc tctcattctc      840

tctcttttct cctcctctcc tggaagtttt cgggtccgag ggaaggagga ccctgcgaaa      900

gctgcgacga ctatcttccc ctggggccat ggactcggac gccagcctgg tgtccagccg      960

cccgtcgtcg ccagagcccg atgacctttt tctgccggcc cggagtaagg gcagcagcgg     1020

cagcgccttc actgggggca ccgtgtcctc gtccaccccg agtgactgcc cgccggagct     1080

gagcgccgag ctgcgcggcg ctatgggctc tgcgggcgcg catcctgtgg acaagctagg     1140

aggcagtggc ttcaagtcat cctcgtccag cacctcgtcg tctacgtcgt cggcggctgc     1200

gtcgtccacc aagaaggaca agaagcaaat gacagagccg gagctgcagc agctgcgtct     1260

caagatcaac agccgcgagc gcaagcgcat gcacgacctc aacatcgcca tggatggcct     1320

ccgcgaggtc atgccgtacg cacacggccc ttcggtgcgc aagctttcca agatcgccac     1380

gctgctgctg gcgcgcaact acatcctcat gctcaccaac tcgctggagg agatgaagcg     1440

actggtgagc gagatctacg ggggccacca cgctggcttc cacccgtcgg cctgcggcgg     1500

cctggcgcac tccgcgcccc tgcccgccgc caccgcgcac ccggcagcag cagcgcacgc     1560

cgcacatcac cccgcggtgc accaccccat cctgccgccc gccgccgcag cggctgctgc     1620

cgccgctgca gccgcggctg tgtccagcgc ctctctgccc ggatccgggc tgccgtcggt     1680

cggctccatc cgtccaccgc acggcctact caagtctccg tctgctgccg cggccgcccc     1740

gctggggggc gggggcggcg gcagtggggc gagcgggggc ttccagcact ggggcggcat     1800

gccctgcccc tgcagcatgt gccaggtgcc gccgccgcac caccacgtgt cggctatggg     1860

cgccggcagc ctgccgcgcc tcacctccga cgccaagtga gcctactggc gccggcgcgt     1920

tctggcgaca ggggagccag gggccgcggg gaagcgagga ctggcctgcg ctgggctcgg     1980

gagctctgtc gcgaggaggg gcgcaggacc atggactggg ggtggggcat ggtggggatt     2040

tcagcatctg cgaacccaag caatgggggc gcccacagag cagtggggag tgaggggatg     2100

ttctctccgg gacctgatcg agcgctgtct ggctttaacc tgagctggtc cagtagacat     2160

cgttttatga aaaggtaccg ctgtgtgcat tcctcactag aactcatccg acccccgacc     2220

cccacctccg ggaaaagatt ctaaaaactt ctttccctga gagcgtggcc tgacttgcag     2280

actcggcttg ggcagcactt cgggggggga gggggtgtta tgggaggggg acacattggg     2340

gccttgctcg tcttcctcct ttcttggcgg gtgggagact ccgggtagcc gcactgcaga     2400

agcaacagcc cgaccgcgcc ctccagggtc gtccctggcc caaggccagg ggccacaagt     2460

tagttggaag ccggcgttcg gtatcagaag cgctgatggt catatccaat ctcaatatct     2520

gggtcaatcc acaccctctt agaactgtgg ccgttcctcc ctgtctctcg ttgatttggg     2580

agaatatggt tttctaataa atctgtggat gttccttctt caacagtatg agcaagttta     2640

tagacattca gagtagaacc acttgtggat tggaataacc caaaactgcc gatttcaggg     2700

gcgggtgcat tgtagttatt attttaaaat agaaactacc ccaccgactc atctttcctt     2760

ctctaagcac aaagtgattt ggttattttg gtacctgaga acgtaacaga attaaaaggc     2820

agttgctgtg gaaacagttt gggttatttg ggggttctgt tggcttttta aaattttctt     2880

ttttggatgt gtaaatttat caatgatgag gtaagtgcgc aatgctaagc tgtttgctca     2940

cgtgactgcc agccccatcg gagtctaagc cggctttcct ctattttggt ttatttttgc     3000

cacgtttaac acaaatggta aactcctcca cgtgcttcct gcgttccgtg caagccgcct     3060

cggcgctgcc tgcgttgcaa actgggcttt gtagcgtctg ccgtgtaaca cccttcctct     3120

gatcgcaccg cccctcgcag agagtgtatc atctgtttta tttttgtaaa aacaaagtgc     3180

taaataatat ttattacttg tttggttgca aaaacggaat aaatgactga gtgttgagat     3240

tttaaataaa atttaaagca aaaaaaaaaa aaaaa                                3275


<210> 33
<211> 432
<212> PRT
<213> Homo sapiens

<400> 33
Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210> 34
<211> 1488
<212> DNA
<213> Homo sapiens

<400> 34
gcaggatgga gaggagacgc atcacctccg ctgctcgccg ctcctacgtc tcctcagggg       60

agatgatggt ggggggcctg gctcctggcc gccgtctggg tcctggcacc cgcctctccc      120

tggctcgaat gccccctcca ctcccgaccc gagtggattt ctccctggct ggggcactca      180

atgctggctt caaggagacc cgggccagtg agcgggcaga gatgatggag ctcaatgacc      240

gctttgccag ctacatcgag aaggttcgct tcctggaaca gcaaaacaag gcgctggctg      300

ctgagctgaa ccagctgcgg gccaaggagc ccaccaagct ggcagacgtc taccaggctg      360

agctgcgaga gctgcggctg cggctcgatc aactcaccgc caacagcgcc cggctggagg      420

ttgagaggga caatctggca caggacctgg ccactgtgag gcagaagctc caggatggaa      480

ccaacctgag gctggaagcc gagaacaacc tggctgccta tagacaggaa gcagatgaag      540

ccaccctggc ccgtctggat ctggagagga agattgagtc gctggaggag gagatccggt      600

tcttgaggaa gatccacgag gaggaggttc gggaactcca ggagcagctg gcccgacagc      660

aggtccatgt ggagcttgac gtggccaagc cagacctcac cgcagccctg aaagagatcc      720

gcacgcagta tgaggcaatg gcgtccagca acatgcatga agccgaagag tggtaccgct      780

ccaagtttgc agacctgaca gacgctgctg cccgcaacgc ggagctgctc cgccaggcca      840

agcacgaagc caacgactac cggcgccagt tgcagtcctt gacctgcgac ctggagtctc      900

tgcgcggcac gaacgagtcc ctggagaggc agatgcgcga gcaggaggag cggcacgtgc      960

gggaggcggc cagttatcag gaggcgctgg cgcggctgga ggaagagggg cagagcctca     1020

aggacgagat ggcccgccac ttgcaggagt accaggacct gctcaatgtc aagctggccc     1080

tggacatcga gatcgccacc tacaggaagc tgctagaggg cgaggagaac cggatcacca     1140

ttcccgtgca gaccttctcc aacctgcaga ttcgagaaac cagcctggac accaagtctg     1200

tgtcagaagg ccacctcaag aggaacatcg tggtgaagac cgtggagatg cgggatggag     1260

aggtcattaa ggagtccaag caggagcaca aggatgtgat gtgaggcagg acccacctgg     1320

tggcctctgc cccgtctcat gaggggcccg agcagaagca ggatagttgc tccgcctctg     1380

ctggcacatt tccccagacc tgagctcccc accaccccag ctgctcccct ccctcctctg     1440

tccctaggtc agcttgctgc cctaggctcc gtcagtatca ggcctgcc                  1488


<210> 35
<211> 92
<212> PRT
<213> Homo sapiens

<400> 35
Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210> 36
<211> 1135
<212> DNA
<213> Homo sapiens

<400> 36
gggcagaggg aataagaggc tgcctctgcc caccagtcct gccgcccagg acccgcagca       60

gagacgacgc ctgcagcaag gagaccagga aggggtgaga caaggaagag gatgtctgag      120

ctggagaagg ccatggtggc cctcatcgac gttttccacc aatattctgg aagggaggga      180

gacaagcaca agctgaagaa atccgaactg aaggagctca tcaacaatga gctttcccat      240

ttcttagagg aaatcaaaga gcaggaggtt gtggacaaag tcatggaaac actggacaat      300

gatggagacg gcgaatgtga cttccaggaa ttcatggcct ttgttgccat ggttactact      360

gcctgccacg agttctttga acatgagtga gattagaaag cagccaaacc tttcctgtaa      420

cagagacggt catgcaagaa agcagacagc aagggcttgc agcctagtag gagctgagct      480

ttccagccgt gttgtagcta attaggaagc ttgatttgct ttgtgattga aaaattgaaa      540

acctctttcc aaaggctgtt ttaacggcct gcatcattct ttctgctata ttaggcctgt      600

gtgtaagctg actggcccca gggactcttg ttaacagtaa cttaggagtc aggtctcagt      660

gataaagcgt gcaccgtgca gcccgccatg gccgtgtaga ccctaacccg gagggaaccc      720

tgactacaga aattaccccg gggcaccctt aaaacttcca ctacctttaa aaaacaaagc      780

cttatccagc attatttgaa aacactgctg ttctttaaat gcgttcctca tccatgcaga      840

taacagctgg ttggccggtg tggccctgca agggcgtggt ggcttcggcc tgcttcccgg      900

gatgcgcctg atcaccaggt gaacgctcag cgctggcagc gctcctggaa aaagcaactc      960

catcagaact cgcaatccga gccagctctg ggggctccag cgtggcctcc gtgacccatg     1020

cgattcaagt cgcggctgca ggatccttgc ctccaacgtg cctccagcac atgcggcttc     1080

cgagggcact accgggggct ctgagccacc gcgagggcct gcgttcaata aaaag          1135


<210> 37
<211> 466
<212> PRT
<213> Homo sapiens

<400> 37
Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210> 38
<211> 2882
<212> DNA
<213> Homo sapiens

<400> 38
gtccggccag ggtggttggt ggtaaggatt caggctccgt cctaacgagg ccgtggcctg       60

aggctcaggg ccccccgccc ctccctccca gcccaccagc gtcacctccc agccccgagc      120

tggaccgcac accttgggac acggttttcc acttcctaag gacgagcccc agactggagg      180

agaggtccga ggaggtgggc gttggactct ttgcgaggac cccggcggct ggcccggggg      240

aggcggccga ggcggcggcg gcggcggccg ggggcgacat ggcggaggag caggacctat      300

cggaggtgga gctgagcccc gtgggctcgg aggagccccg ctgcctgtcc ccggggagcg      360

cgccctcgct agggcccgac ggcggcggcg gcggatcggg cctgcgagcc agcccggggc      420

caggcgagct gggcaaggtc aagaaggagc agcaggacgg cgaggcggac gatgacaagt      480

tccccgtgtg catccgcgag gccgtcagcc aggtgctcag cggctacgac tggacgctgg      540

tgcccatgcc cgtgcgcgtc aacggcgcca gcaaaagcaa gccgcacgtc aagcggccca      600

tgaacgcctt catggtgtgg gctcaggcag cgcgcaggaa gctcgcggac cagtacccgc      660

acctgcacaa cgctgagctc agcaagacgc tgggcaagct ctggaggctg ctgaacgaaa      720

gtgacaagcg ccccttcatc gaggaggctg agcggctccg tatgcagcac aagaaagacc      780

acccggacta caagtaccag cccaggcggc ggaagaacgg gaaggccgcc cagggcgagg      840

cggagtgccc cggtggggag gccgagcaag gtgggaccgc cgccatccag gcccactaca      900

agagcgccca cttggaccac cggcacccag gagagggctc ccccatgtca gatgggaacc      960

ccgagcaccc ctcaggccag agccatggcc cacccacccc tccaaccacc ccgaagacag     1020

agctgcagtc gggcaaggca gacccgaagc gggacgggcg ctccatgggg gagggcggga     1080

agcctcacat cgacttcggc aacgtggaca ttggtgagat cagccacgag gtaatgtcca     1140

acatggagac ctttgatgtg gctgagttgg accagtacct gccgcccaat gggcacccag     1200

gccatgtgag cagctactca gcagccggct atgggctggg cagtgccctg gccgtggcca     1260

gtggacactc cgcctggatc tccaagccac caggcgtggc tctgcccacg gtctcaccac     1320

ctggtgtgga tgccaaagcc caggtgaaga cagagaccgc ggggccccag gggcccccac     1380

actacaccga ccagccatcc acctcacaga tcgcctacac ctccctcagc ctgccccact     1440

atggctcagc cttcccctcc atctcccgcc cccagtttga ctactctgac catcagccct     1500

caggacccta ttatggccac tcgggccagg cctctggcct ctactcggcc ttctcctata     1560

tggggccctc gcagcggccc ctctacacgg ccatctctga ccccagcccc tcagggcccc     1620

agtcccacag ccccacacac tgggagcagc cagtatatac gacactgtcc cggccctaaa     1680

gggggccctg tcgccaccac cccccgccca gcccctgccc ccagcctgtg tgccctgttc     1740

cttgcccacc tcaggcctgg tggtggcagt ggaggaggct gaggaggctg aagaggctga     1800

caggtcgggg ggctttctgt ctggctcact gccctgatga cccacccgcc ccatccaggc     1860

tccagcagca aagccccagg agaacaggct ggacagagga gaaggaggtt gactgttgca     1920

cccacactga aagatgaggg gctgcacctt cccccaggaa tgaccctcta tcccaggacc     1980

tgagaagggc ctgctcaccc tcctcgggga ggggaagcac cagggttggt ggcatcggag     2040

gccttaccac tcctatgact cctgttttct ctctcacaga tagtgagggt ctgacatgcc     2100

catgccacct atgccacagt gcctaagggc taggccaccc agagactgtg cccggagctg     2160

gccgtgtctc ccactcaggg gctgagagta gctttgagga gcctcattgg ggagtggggg     2220

gttcgaggga cttagtggag ttctcatccc ttcaatgccc cctccctttc tgaaggcagg     2280

aaggagttgg cacagaggcc ccctgatcca attctgtgcc aataacctca ttctttgtct     2340

gagaaacagc ccccagtcct cctccactac aacctccatg accttgagac gcatcccagg     2400

aggtgacgag gcaggggctc caggaaagga atcagagaca attcacagag cctccctccc     2460

tgggctcctt gccagctccc tcttccctta ctaggctcta tggcccctgc tcagtcagcc     2520

ccactccctg ggcttcccag agagtgacag ctgctcaggc cctaaccctt ggctccagga     2580

gacacagggc ccagcaccca ggttgctgtc ggcaggctga agacactaga atcctgacct     2640

gtacattctg cccttgcctc ttaccccttg cctcccagtg gtatttgaat aaagtatgta     2700

gctatatctg cccctatttt cctgttctgc agccccccaa atccacatgt aactcattac     2760

tgtctcctgt tatttatctc agtagtcccc tctcctagcc actctagccc ctattaactc     2820

tgcattaagc attccacata ataaaattaa aggttccggt taaaaaaaaa aaaaaaaaaa     2880

aa                                                                    2882


<210> 39
<211> 705
<212> PRT
<213> Homo sapiens

<400> 39
Met Asn Tyr Leu Arg Arg Arg Leu Ser Asp Ser Asn Phe Met Ala Asn 
1               5                   10                  15      


Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Gln Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Gly Ala His Ser Pro Gly Ala Thr Pro Gly Pro Gly Thr 
        35                  40                  45              


Ala Thr Ala Glu Arg Ser Ser Gly Val Ala Pro Ala Ala Ser Pro Ala 
    50                  55                  60                  


Ala Pro Ser Pro Gly Ser Ser Gly Gly Gly Gly Phe Phe Ser Ser Leu 
65                  70                  75                  80  


Ser Asn Ala Val Lys Gln Thr Thr Ala Ala Ala Ala Ala Thr Phe Ser 
                85                  90                  95      


Glu Gln Val Gly Gly Gly Ser Gly Gly Ala Gly Arg Gly Gly Ala Ala 
            100                 105                 110         


Ser Arg Val Leu Leu Val Ile Asp Glu Pro His Thr Asp Trp Ala Lys 
        115                 120                 125             


Tyr Phe Lys Gly Lys Lys Ile His Gly Gly Ile Asp Ile Lys Val Glu 
    130                 135                 140                 


Gln Ala Glu Phe Ser Asp Leu Asn Leu Val Ala His Ala Asn Gly Gly 
145                 150                 155                 160 


Phe Ser Val Asp Met Glu Val Leu Arg Asn Gly Val Lys Val Val Arg 
                165                 170                 175     


Ser Leu Lys Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Ser Met 
            180                 185                 190         


Ala Arg Asn Gly Asp Tyr Arg Ser Leu Val Ile Gly Leu Gln Tyr Ala 
        195                 200                 205             


Gly Ile Pro Ser Val Asn Ser Leu His Ser Val Tyr Asn Phe Cys Asp 
    210                 215                 220                 


Lys Pro Trp Val Phe Ala Gln Met Val Arg Leu His Lys Lys Leu Gly 
225                 230                 235                 240 


Thr Glu Glu Phe Pro Leu Ile Asp Gln Thr Phe Tyr Pro Asn His Lys 
                245                 250                 255     


Glu Met Leu Ser Ser Thr Thr Tyr Pro Val Val Val Lys Met Gly His 
            260                 265                 270         


Ala His Ser Gly Met Gly Lys Val Lys Val Asp Asn Gln His Asp Phe 
        275                 280                 285             


Gln Asp Ile Ala Ser Val Val Ala Leu Thr Lys Thr Tyr Ala Thr Ala 
    290                 295                 300                 


Glu Pro Phe Ile Asp Ala Lys Tyr Asp Val Arg Val Gln Lys Ile Gly 
305                 310                 315                 320 


Gln Asn Tyr Lys Ala Tyr Met Arg Thr Ser Val Ser Gly Asn Trp Lys 
                325                 330                 335     


Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
            340                 345                 350         


Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Ile Phe Gly Gly Leu Asp 
        355                 360                 365             


Ile Cys Ala Val Glu Ala Leu His Gly Lys Asp Gly Arg Asp His Ile 
    370                 375                 380                 


Ile Glu Val Val Gly Ser Ser Met Pro Leu Ile Gly Asp His Gln Asp 
385                 390                 395                 400 


Glu Asp Lys Gln Leu Ile Val Glu Leu Val Val Asn Lys Met Ala Gln 
                405                 410                 415     


Ala Leu Pro Arg Gln Arg Gln Arg Asp Ala Ser Pro Gly Arg Gly Ser 
            420                 425                 430         


His Gly Gln Thr Pro Ser Pro Gly Ala Leu Pro Leu Gly Arg Gln Thr 
        435                 440                 445             


Ser Gln Gln Pro Ala Gly Pro Pro Ala Gln Gln Arg Pro Pro Pro Gln 
    450                 455                 460                 


Gly Gly Pro Pro Gln Pro Gly Pro Gly Pro Gln Arg Gln Gly Pro Pro 
465                 470                 475                 480 


Leu Gln Gln Arg Pro Pro Pro Gln Gly Gln Gln His Leu Ser Gly Leu 
                485                 490                 495     


Gly Pro Pro Ala Gly Ser Pro Leu Pro Gln Arg Leu Pro Ser Pro Thr 
            500                 505                 510         


Ser Ala Pro Gln Gln Pro Ala Ser Gln Ala Ala Pro Pro Thr Gln Gly 
        515                 520                 525             


Gln Gly Arg Gln Ser Arg Pro Val Ala Gly Gly Pro Gly Ala Pro Pro 
    530                 535                 540                 


Ala Ala Arg Pro Pro Ala Ser Pro Ser Pro Gln Arg Gln Ala Gly Pro 
545                 550                 555                 560 


Pro Gln Ala Thr Arg Gln Thr Ser Val Ser Gly Pro Ala Pro Pro Lys 
                565                 570                 575     


Ala Ser Gly Ala Pro Pro Gly Gly Gln Gln Arg Gln Gly Pro Pro Gln 
            580                 585                 590         


Lys Pro Pro Gly Pro Ala Gly Pro Thr Arg Gln Ala Ser Gln Ala Gly 
        595                 600                 605             


Pro Val Pro Arg Thr Gly Pro Pro Thr Thr Gln Gln Pro Arg Pro Ser 
    610                 615                 620                 


Gly Pro Gly Pro Ala Gly Ala Pro Lys Pro Gln Leu Ala Gln Lys Pro 
625                 630                 635                 640 


Ser Gln Asp Val Pro Pro Pro Ala Thr Ala Ala Ala Gly Gly Pro Pro 
                645                 650                 655     


His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr Asn Ala Phe Asn Leu 
            660                 665                 670         


Pro Glu Pro Ala Pro Pro Arg Pro Ser Leu Ser Gln Asp Glu Val Lys 
        675                 680                 685             


Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe Ala Ser Leu Phe Ser 
    690                 695                 700                 


Asp 
705 


<210> 40
<211> 2470
<212> DNA
<213> Homo sapiens

<400> 40
ctcgagagag aaggagagga cattcctggc agaagttaca acacatgcaa aggtacagag       60

gttgccccct tcctacccct ctccttagag gtgggttaga gatgtatcct ttttacagat      120

gaggaaacca aatctcagaa agattaagtc actttcccaa gtgtatggtg gaggccccac      180

ttgaacccag gcactgtgtc tccagacccc acactattac tgccttgttt aaaccagcca      240

actgatttaa tgaataaagg atgaacaaat gaataagtgg atgagtcacc tgaaaattct      300

gcaggcaaag agactccata tctacttact tcttgcctat cttctgccac ctctcctagt      360

ccaccatcac tgctcactat ggtcaaggtc ctacccaatc tggcccctgc taccacaacc      420

cccttcagct tgttccagcc acattggcac tggatgtttc ctcttcctgg cacattctta      480

aaaaaatgtg ttgatcataa agtgaacatg accctttggg aattaactgg agttcttgta      540

ttccctcatc tgtaaaatag acattatatt atccacccca ctggattgtt gtgagggtgg      600

gatgaaatga tgcatgtaaa cacgcttagc ttaagagttg ggtacaatca gtgaacaaat      660

gattatgaat tagtgctttt attgtagtca gaatcataaa gatttgacag gttcccatat      720

cccacctctg cttggactac ctcatttgct catatgcaaa gattatttgg tacctactgt      780

gtgtgcacca tgggatgggc ctgcctctgt ggaaagttct tgggtgcagg gggagacagc      840

catgggcact gatgacatca ggtagttatc gtgagttttg gcggtgtcca gagcaaaggg      900

atggtggcgt atataccaag tgtgttctgg tgtgggggtg gacacgcacc agggctaggg      960

ctgcagagaa tgtctgtgtt gcagatctag gtttctccat gatcatcggt gggaatgtgt     1020

tttgtctgca agtgtatgct catatgagtt tccctgggtc tctgtgtgtc agtgtgttac     1080

ctgtgtgtgt gggggtatgg gtgtatgcat gcatgtatgt aacatgccca tgtgtgttac     1140

tctggacttg tatgtctgta tgtataccta gattggcgtg tgttctgtct gtacatgccc     1200

tcgtatgttt cctcactttt gtgtgtgttt atatgtgtgt catttcttgt gtgccctcca     1260

ggcccccctt gccaccttgg gcaagggtgt gtacaccacc caagtgtcca cctccgcttg     1320

tctgatgctg tctgtgacgc ccccgctctc tgcctagctg agcctgtgtg gatgtgggag     1380

actaatctcc ccgcgggcac tgcgtgtgac ctcacccccc tctgtgaggg ggttatttct     1440

ctactttcgt gtctctgagt gtgcttccag tgcccccctc cccccaaaaa atgccttctg     1500

agttgaatat caacactaca aaccgagtat ctgcagactg cagagggccc tgcgtatgag     1560

tgcaagtggg ttttaggacc aggatgaggc ggggtggggg tgcctacctg acgaccgacc     1620

ccgacccact ggacaagcac ccaaccccca ttccccaaat tgcgcatccc ctatcagaga     1680

gggggagggg aaacaggatg cggcgaggcg cgtcgcgact gccagcttca gcaccgcgga     1740

cagtgccttc gcccccgcct ggcggcgcgc gccaccgccg cctcagcact gaaggcgcgc     1800

tgacgtcact cgccggtccc ccgcaaactc cccttcccgg ccaccttggt cgcgtccgcg     1860

ccgccgccgg cccagccgga ccgcaccacg cgaggcgcga gatagggggg cacgggcgcg     1920

accatctgcg ctgcggcgcc ggcgactcag cgctgcctca gtctgcggtg ggcagcggag     1980

gagtcgtgtc gtgcctgaga gcgcagctgt gctcctgggc accgcgcagt ccgcccccgc     2040

ggctcctggc cagaccaccc ctaggacccc ctgccccaag tcgcagccat gaactacctg     2100

cggcgccgcc tgtcggacag caactttatg gccaatctgc caaatgggta catgacagac     2160

ctgcagcgtc cgcagccgcc cccaccgccg cccggtgccc acagccccgg agccacgccc     2220

ggtcccggga ccgccactgc cgagaggtcc tccggggtcg ccccagcggc ctctccggcc     2280

gcccctagcc ccgggtcctc ggggggcggt ggcttcttct cgtcgctgtc caacgcggtc     2340

aagcagacca cggcggcggc agctgccacc ttcagcgagc aggtgggcgg cggctctggg     2400

ggcgcaggcc gcgggggagc cgcctccagg gtgctgctgg tcatcgacga gccgcacacc     2460

gactggtaag                                                            2470


<210> 41
<211> 313
<212> PRT
<213> Homo sapiens

<400> 41
Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210> 42
<211> 2449
<212> DNA
<213> Homo sapiens

<400> 42
gccccctgca ttgctgatgc tgctgctggc ggacatggac gtggtgaatc agctggtggc       60

tgggggtcag ttccgggtgg tcaaggagcc cctcggcttt gtgaaggtgc tgcaatgggt      120

cttcgccatc ttcgcctttg ccacatgcgg cagctacagt ggggagctcc agctgagcgt      180

ggattgtgcc aacaagaccg agagtgacct cagcatcgag gtcgagttcg agtacccctt      240

caggctgcac caagtgtact ttgatgcacc cacctgccga gggggcacca ccaaggtctt      300

cttagttggg gactactcct cgtcagccga attctttgtc accgtggccg tgtttgcctt      360

cctctactcc atgggggctc tggccaccta catcttcctg cagaacaagt accgagagaa      420

taacaaaggg cccatgctgg actttctggc cacggctgtg ttcgccttca tgtggctagt      480

tagctcatcg gcatgggcca aggggctgtc agatgtgaag atggccacag acccagagaa      540

cattatcaag gagatgcctg tctgccgcca gacagggaac acatgcaagg agctgagaga      600

ccctgtgacc tcgggactca acacctcggt ggtgttcggc ttcctgaacc tggtgctctg      660

ggtcggcaac ctgtggttcg tgtttaagga gacaggctgg gccgccccgt tcctgcgcgc      720

gcctcccggc gcccccgaga aacaaccggc acccggggac gcctacggcg atgcaggcta      780

cgggcagggc cccggcgggt acgggcccca ggattcctac gggcctcagg gcggctacca      840

gcctgactat ggtcaaccag ccggcagcgg tggcagtggc tacgggcctc agggcgacta      900

tgggcagcaa ggctacggcc cgcagggtgc acccacctcc ttctccaatc agatgtagtc      960

tggtcagtga agcccaggag gacctggggg gggcaagagc tcaggagaag gcctgccccc     1020

cttcccaccc ctatacccta ggtctccacc cctcaagcca ggagaccctg tctttgctgt     1080

ttatatatat atatattata tataaatatc tatttatctg tctgagccct gccctcactc     1140

cactcccctc atccactagg tgcccagtct tgagtgggcc ccctctctta ccccgtccct     1200

ttccctgcat cccttggccc ctctctgttt accctccctg tcccctgagg ttaaggggat     1260

ctaaaaggag gacagggagg gaacagacct cggctgtgtg gggagggtgg gcgtgacttc     1320

agactctctc ctctctctcc ctccactcct cccaactctg gccttggttc ctccagcaat     1380

gcctgcctga acaaaggccg ttagggaaat ccaactccag ggttaaagaa aggcagagat     1440

tgggggggct tggggtagag aggacagttt aggacccaag gtggtcttgg agaggaggtg     1500

tggagtggag gggtcagcag gggggttggg ttccagacag agtggatctg gagtctgaag     1560

gagaggagtg cgctagagca ttctggggtg gggcttggaa gggcgctgag ggcagggttc     1620

tagaaggggc gaggctttaa gcgaggcaga atggtgggct ccagagtagg tgggtcttgg     1680

attggtacca gagcctatgg aaagggtgtg gcttggaaca tttgggagac tgagcttgat     1740

tctaaagggg acagatcttg agcaaggcaa gaagtgggat tcaggaatgg gccaagccag     1800

ggttccagac agggtggggc ttagaatggg gcttccatgg tggtttcaga aagggcagcc     1860

cctccccatg gtgcagtgaa gaaaatgttt tacaatggct gggtttgggc agtggagagg     1920

ggacttggat aggagcttcc agatgggttt tgttaggggt gggggagaat ggctctggct     1980

acgacttggg acggaagtgg cctgagaaga gtcgagtgat atggcttgta gggtgaggcg     2040

tgggatccag agagaagcac cccaccacac acacccttcc ccactcccgt gatgaaacag     2100

ctaggttaat aggaggacag aaccaacggg tctgtgggac tggcccaccc ctcttccccc     2160

ttcccctgcg ccctccctcc ctccacacct ccacccgtcc tggggtggtt ggaggcctgg     2220

tctggagccc ctatcctgca ccctctgcta tgtctgtgat gtcagtagtg cctgtgatcg     2280

tgtgttgcca ttttgtctgg ctgtggcccc tccttctccc ctccagaccc ctaccctttc     2340

ccaaaccctt cggtattgtt caaagaaccc ccctccccaa ggaagaacaa atatgattct     2400

cctctcccaa ataaactcct taaccaccta gtcaaaaaaa aaaaaaaaa                 2449


<210> 43
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 43
Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu 
            180                 185                 190         


Pro Ala Ala Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp 
        195                 200                 205             


Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe 
    210                 215                 220                 


Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
225                 230                 235                 240 


Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser 
                245                 250                 255     


Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala 
            260                 265                 270         


Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp 
        275                 280                 285             


Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
    290                 295                 300                 


Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg 
305                 310                 315                 320 


Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser 
                325                 330                 335     


Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys 
            340                 345                 350         


Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser 
        355                 360                 365             


Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr 
    370                 375                 380                 


Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys 
385                 390                 395                 400 


Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu 
                405                 410                 415     


Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr 
            420                 425                 430         


Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro 
        435                 440                 445             


Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys 
    450                 455                 460                 


Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe 
465                 470                 475                 480 


Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys 
                485                 490                 495     


Ile Glu Glu Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr 
            500                 505                 510         


Lys Thr Ser Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp 
        515                 520                 525             


Tyr Val Thr Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala 
    530                 535                 540                 


Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu 
545                 550                 555                 560 


Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys 
                565                 570                 575     


Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro 
            580                 585                 590         


Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser 
        595                 600                 605             


Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val 
    610                 615                 620                 


Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu 
625                 630                 635                 640 


Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro 
                645                 650                 655     


Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly 
            660                 665                 670         


Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln 
        675                 680                 685             


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
    690                 695                 700                 


Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu 
705                 710                 715                 720 


Met Ala Lys Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu 
                725                 730                 735     


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
            740                 745                 750         


Ile Pro Asp Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys 
        755                 760                 765             


Glu Ser Leu Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu 
785                 790                 795                 800 


Glu Ser Phe Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro 
                805                 810                 815     


Asp Glu Val Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met 
            820                 825                 830         


Glu Glu Leu Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser 
        835                 840                 845             


Lys Glu Ala Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro 
    850                 855                 860                 


Ile Glu Ile Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp 
865                 870                 875                 880 


Ser Phe Ser Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His 
                885                 890                 895     


Lys Ser Glu Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys 
            900                 905                 910         


Thr Glu Leu Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val 
        915                 920                 925             


Glu Glu Lys Ile Ser Phe Ser Asp Asp Phe Ser Lys Asn Gly Ser Ala 
    930                 935                 940                 


Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val Ser Ala Leu Ala Thr 
945                 950                 955                 960 


Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys Val Leu Val Lys Glu 
                965                 970                 975     


Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp Arg Ser Pro 
            980                 985                 990         


Ser Ala Ile Phe Ser Ala Glu Leu  Ser Lys Thr Ser Val  Val Asp Leu 
        995                 1000                 1005             


Leu Tyr  Trp Arg Asp Ile Lys  Lys Thr Gly Val Val  Phe Gly Ala 
    1010                 1015                 1020             


Ser Leu  Phe Leu Leu Leu Ser  Leu Thr Val Phe Ser  Ile Val Ser 
    1025                 1030                 1035             


Val Thr  Ala Tyr Ile Ala Leu  Ala Leu Leu Ser Val  Thr Ile Ser 
    1040                 1045                 1050             


Phe Arg  Ile Tyr Lys Gly Val  Ile Gln Ala Ile Gln  Lys Ser Asp 
    1055                 1060                 1065             


Glu Gly  His Pro Phe Arg Ala  Tyr Leu Glu Ser Glu  Val Ala Ile 
    1070                 1075                 1080             


Ser Glu  Glu Leu Val Gln Lys  Tyr Ser Asn Ser Ala  Leu Gly His 
    1085                 1090                 1095             


Val Asn  Cys Thr Ile Lys Glu  Leu Arg Arg Leu Phe  Leu Val Asp 
    1100                 1105                 1110             


Asp Leu  Val Asp Ser Leu Lys  Phe Ala Val Leu Met  Trp Val Phe 
    1115                 1120                 1125             


Thr Tyr  Val Gly Ala Leu Phe  Asn Gly Leu Thr Leu  Leu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Ile Ser Leu Phe Ser  Val Pro Val Ile Tyr  Glu Arg His 
    1145                 1150                 1155             


Gln Ala  Gln Ile Asp His Tyr  Leu Gly Leu Ala Asn  Lys Asn Val 
    1160                 1165                 1170             


Lys Asp  Ala Met Ala Lys Ile  Gln Ala Lys Ile Pro  Gly Leu Lys 
    1175                 1180                 1185             


Arg Lys  Ala Glu 
    1190         


<210> 44
<211> 4871
<212> DNA
<213> Homo sapiens

<400> 44
agtccctgcc ctcccctggg gagggtgagt cacgccaaac tgggcggaga gtccgctggc       60

ctcactccta gctcatctgg gcggcggcgg caagtgggga cagggcgggt ggcgcatcac      120

cggcgcggag gcaggaggag cagtctcatt gttccgggag ccgtcaccac agtaggtccc      180

tcggctcagt cggcccagcc cctctcagtc ctccccaacc cccacaaccg cccgcggctc      240

tgagacgcgg ccccggcggc ggcggcagca gctgcagcat catctccacc ctccagccat      300

ggaagacctg gaccagtctc ctctggtctc gtcctcggac agcccacccc ggccgcagcc      360

cgcgttcaag taccagttcg tgagggagcc cgaggacgag gaggaagaag aggaggagga      420

agaggaggac gaggacgaag acctggagga gctggaggtg ctggagagga agcccgccgc      480

cgggctgtcc gcggccccag tgcccaccgc ccctgccgcc ggcgcgcccc tgatggactt      540

cggaaatgac ttcgtgccgc cggcgccccg gggacccctg ccggccgctc cccccgtcgc      600

cccggagcgg cagccgtctt gggacccgag cccggtgtcg tcgaccgtgc ccgcgccatc      660

cccgctgtct gctgccgcag tctcgccctc caagctccct gaggacgacg agcctccggc      720

ccggcctccc cctcctcccc cggccagcgt gagcccccag gcagagcccg tgtggacccc      780

gccagccccg gctcccgccg cgcccccctc caccccggcc gcgcccaagc gcaggggctc      840

ctcgggctca gtggatgaga ccctttttgc tcttcctgct gcatctgagc ctgtgatacg      900

ctcctctgca gaaaatatgg acttgaagga gcagccaggt aacactattt cggctggtca      960

agaggatttc ccatctgtcc tgcttgaaac tgctgcttct cttccttctc tgtctcctct     1020

ctcagccgct tctttcaaag aacatgaata ccttggtaat ttgtcaacag tattacccac     1080

tgaaggaaca cttcaagaaa atgtcagtga agcttctaaa gaggtctcag agaaggcaaa     1140

aactctactc atagatagag atttaacaga gttttcagaa ttagaatact cagaaatggg     1200

atcatcgttc agtgtctctc caaaagcaga atctgccgta atagtagcaa atcctaggga     1260

agaaataatc gtgaaaaata aagatgaaga agagaagtta gttagtaata acatccttca     1320

taatcaacaa gagttaccta cagctcttac taaattggtt aaagaggatg aagttgtgtc     1380

ttcagaaaaa gcaaaagaca gttttaatga aaagagagtt gcagtggaag ctcctatgag     1440

ggaggaatat gcagacttca aaccatttga gcgagtatgg gaagtgaaag atagtaagga     1500

agatagtgat atgttggctg ctggaggtaa aatcgagagc aacttggaaa gtaaagtgga     1560

taaaaaatgt tttgcagata gccttgagca aactaatcac gaaaaagata gtgagagtag     1620

taatgatgat acttctttcc ccagtacgcc agaaggtata aaggatcgtt caggagcata     1680

tatcacatgt gctcccttta acccagcagc aactgagagc attgcaacaa acatttttcc     1740

tttgttagga gatcctactt cagaaaataa gaccgatgaa aaaaaaatag aagaaaagaa     1800

ggcccaaata gtaacagaga agaatactag caccaaaaca tcaaaccctt ttcttgtagc     1860

agcacaggat tctgagacag attatgtcac aacagataat ttaacaaagg tgactgagga     1920

agtcgtggca aacatgcctg aaggcctgac tccagattta gtacaggaag catgtgaaag     1980

tgaattgaat gaagttactg gtacaaagat tgcttatgaa acaaaaatgg acttggttca     2040

aacatcagaa gttatgcaag agtcactcta tcctgcagca cagctttgcc catcatttga     2100

agagtcagaa gctactcctt caccagtttt gcctgacatt gttatggaag caccattgaa     2160

ttctgcagtt cctagtgctg gtgcttccgt gatacagccc agctcatcac cattagaagc     2220

ttcttcagtt aattatgaaa gcataaaaca tgagcctgaa aaccccccac catatgaaga     2280

ggccatgagt gtatcactaa aaaaagtatc aggaataaag gaagaaatta aagagcctga     2340

aaatattaat gcagctcttc aagaaacaga agctccttat atatctattg catgtgattt     2400

aattaaagaa acaaagcttt ctgctgaacc agctccggat ttctctgatt attcagaaat     2460

ggcaaaagtt gaacagccag tgcctgatca ttctgagcta gttgaagatt cctcacctga     2520

ttctgaacca gttgacttat ttagtgatga ttcaatacct gacgttccac aaaaacaaga     2580

tgaaactgtg atgcttgtga aagaaagtct cactgagact tcatttgagt caatgataga     2640

atatgaaaat aaggaaaaac tcagtgcttt gccacctgag ggaggaaagc catatttgga     2700

atcttttaag ctcagtttag ataacacaaa agataccctg ttacctgatg aagtttcaac     2760

attgagcaaa aaggagaaaa ttcctttgca gatggaggag ctcagtactg cagtttattc     2820

aaatgatgac ttatttattt ctaaggaagc acagataaga gaaactgaaa cgttttcaga     2880

ttcatctcca attgaaatta tagatgagtt ccctacattg atcagttcta aaactgattc     2940

attttctaaa ttagccaggg aatatactga cctagaagta tcccacaaaa gtgaaattgc     3000

taatgccccg gatggagctg ggtcattgcc ttgcacagaa ttgccccatg acctttcttt     3060

gaagaacata caacccaaag ttgaagagaa aatcagtttc tcagatgact tttctaaaaa     3120

tgggtctgct acatcaaagg tgctcttatt gcctccagat gtttctgctt tggccactca     3180

agcagagata gagagcatag ttaaacccaa agttcttgtg aaagaagctg agaaaaaact     3240

tccttccgat acagaaaaag aggacagatc accatctgct atattttcag cagagctgag     3300

taaaacttca gttgttgacc tcctgtactg gagagacatt aagaagactg gagtggtgtt     3360

tggtgccagc ctattcctgc tgctttcatt gacagtattc agcattgtga gcgtaacagc     3420

ctacattgcc ttggccctgc tctctgtgac catcagcttt aggatataca agggtgtgat     3480

ccaagctatc cagaaatcag atgaaggcca cccattcagg gcatatctgg aatctgaagt     3540

tgctatatct gaggagttgg ttcagaagta cagtaattct gctcttggtc atgtgaactg     3600

cacgataaag gaactcaggc gcctcttctt agttgatgat ttagttgatt ctctgaagtt     3660

tgcagtgttg atgtgggtat ttacctatgt tggtgccttg tttaatggtc tgacactact     3720

gattttggct ctcatttcac tcttcagtgt tcctgttatt tatgaacggc atcaggcaca     3780

gatagatcat tatctaggac ttgcaaataa gaatgttaaa gatgctatgg ctaaaatcca     3840

agcaaaaatc cctggattga agcgcaaagc tgaatgaaaa cgcccaaaat aattagtagg     3900

agttcatctt taaaggggat attcatttga ttatacgggg gagggtcagg gaagaacgaa     3960

ccttgacgtt gcagtgcagt ttcacagatc gttgttagat ctttattttt agccatgcac     4020

tgttgtgagg aaaaattacc tgtcttgact gccatgtgtt catcatctta agtattgtaa     4080

gctgctatgt atggatttaa accgtaatca tatctttttc ctatctatct gaggcactgg     4140

tggaataaaa aacctgtata ttttactttg ttgcagatag tcttgccgca tcttggcaag     4200

ttgcagagat ggtggagcta gaaaaaaaaa aaaaaaagcc cttttcagtt tgtgcactgt     4260

gtatggtccg tgtagattga tgcagatttt ctgaaatgaa atgtttgttt agacgagatc     4320

ataccggtaa agcaggaatg acaaagcttg cttttctggt atgttctagg tgtattgtga     4380

cttttactgt tatattaatt gccaatataa gtaaatatag attatatatg tatagtgttt     4440

cacaaagctt agacctttac cttccagcca ccccacagtg cttgatattt cagagtcagt     4500

cattggttat acatgtgtag ttccaaagca cataagctag aagaagaaat atttctagga     4560

gcactaccat ctgttttcaa catgaaatgc cacacacata gaactccaac atcaatttca     4620

ttgcacagac tgactgtagt taattttgtc acagaatcta tggactgaat ctaatgcttc     4680

caaaaatgtt gtttgtttgc aaatatcaaa cattgttatg caagaaatta ttaattacaa     4740

aatgaagatt tataccattg tggtttaagc tgtactgaac taaatctgtg gaatgcattg     4800

tgaactgtaa aagcaaagta tcaataaagc ttatagactt aaaaaaaaaa aaaaaaaaaa     4860

aaaaaaaaaa a                                                          4871


<210> 45
<211> 432
<212> PRT
<213> Homo sapiens

<400> 45
Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210> 46
<211> 3097
<212> DNA
<213> Homo sapiens

<400> 46
atcgccagtc tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag       60

agcaggatgg agaggagacg catcacctcc gctgctcgcc gctcctacgt ctcctcaggg      120

gagatgatgg tggggggcct ggctcctggc cgccgtctgg gtcctggcac ccgcctctcc      180

ctggctcgaa tgccccctcc actcccgacc cgggtggatt tctccctggc tggggcactc      240

aatgctggct tcaaggagac ccgggccagt gagcgggcag agatgatgga gctcaatgac      300

cgctttgcca gctacatcga gaaggttcgc ttcctggaac agcaaaacaa ggcgctggct      360

gctgagctga accagctgcg ggccaaggag cccaccaagc tggcagacgt ctaccaggct      420

gagctgcgag agctgcggct gcggctcgat caactcaccg ccaacagcgc ccggctggag      480

gttgagaggg acaatctggc acaggacctg gccactgtga ggcagaagct ccaggatgaa      540

accaacctga ggctggaagc cgagaacaac ctggctgcct atagacagga agcagatgaa      600

gccaccctgg cccgtctgga tctggagagg aagattgagt cgctggagga ggagatccgg      660

ttcttgagga agatccacga ggaggaggtt cgggaactcc aggagcagct ggcccgacag      720

caggtccatg tggagcttga cgtggccaag ccagacctca ccgcagccct gaaagagatc      780

cgcacgcagt atgaggcaat ggcgtccagc aacatgcatg aagccgaaga gtggtaccgc      840

tccaagtttg cagacctgac agacgctgct gcccgcaacg cggagctgct ccgccaggcc      900

aagcacgaag ccaacgacta ccggcgccag ttgcagtcct tgacctgcga cctggagtct      960

ctgcgcggca cgaacgagtc cctggagagg cagatgcgcg agcaggagga gcggcacgtg     1020

cgggaggcgg ccagttatca ggaggcgctg gcgcggctgg aggaagaggg gcagagcctc     1080

aaggacgaga tggcccgcca cttgcaggag taccaggacc tgctcaatgt caagctggcc     1140

ctggacatcg agatcgccac ctacaggaag ctgctagagg gcgaggagaa ccggatcacc     1200

attcccgtgc agaccttctc caacctgcag attcgagaaa ccagcctgga caccaagtct     1260

gtgtcagaag gccacctcaa gaggaacatc gtggtgaaga ccgtggagat gcgggatgga     1320

gaggtcatta aggagtccaa gcaggagcac aaggatgtga tgtgaggcag gacccacctg     1380

gtggcctctg ccccgtctca tgaggggccc gagcagaagc aggatagttg ctccgcctct     1440

gctggcacat ttccccagac ctgagctccc caccacccca gctgctcccc tccctcctct     1500

gtccctaggt cagcttgctg ccctaggctc cgtcagtatc aggcctgcca gacggcaccc     1560

acccagcacc cagcaactcc aactaacaag aaactcaccc ccaaggggca gtctggaggg     1620

gcatggccag cagcttgcgt tagaatgagg aggaaggaga gaaggggagg agggcggggg     1680

gcacctacta catcgccctc cacatccctg attcctgttg ttatggaaac tgttgccaga     1740

gatggaggtt ctctcggagt atctgggaac tgtgcctttg agtttcctca ggctgctgga     1800

ggaaaactga gactcagaca ggaaagggaa ggccccacag acaaggtagc cctggccaga     1860

ggcttgtttt gtcttttggt ttttatgagg tgggatatcc ctatgctgcc taggctgacc     1920

ttgaactcct gggctcaagc agtctaccca cctcagcctc ctgtgtagct gggattatag     1980

attggagcca ccatgcccag ctcagagggt tgttctccta gactgaccct gatcagtcta     2040

agatgggtgg ggacgtcctg ccacctgggg cagtcacctg cccagatccc agaaggacct     2100

cctgagcgat gactcaagtg tctcagtcca cctgagctgc catccaggga tgccatctgt     2160

gggcacgctg tgggcaggtg ggagcttgat tctcagcact tgggggatct gttgtgtacg     2220

tggagaggga tgaggtgctg ggagggatag aggggggctg cctggccccc agctgtgggt     2280

acagagaggt caagcccagg aggactgccc cgtgcagact ggaggggacg ctggtagaga     2340

tggaggagga ggcaattggg atggcgctag gcatacaagt aggggttgtg ggtgaccagt     2400

tgcacttggc ctctggattg tgggaattaa ggaagtgact catcctcttg aagatgctga     2460

aacaggagag aaaggggatg tatccatggg ggcagggcat gactttgtcc catttctaaa     2520

ggcctcttcc ttgctgtgtc ataccaggcc gccccagcct ctgagcccct gggactgctg     2580

cttcttaacc ccagtaagcc actgccacac gtctgaccct ctccacccca tagtgaccgg     2640

ctgcttttcc ctaagccaag ggcctcttgc ggtcccttct tactcacaca caaaatgtac     2700

ccagtattct aggtagtgcc ctattttaca attgtaaaac tgaggcacga gcaaagtgaa     2760

gacactggct catattcctg cagcctggag gccgggtgct cagggctgac acgtccaccc     2820

cagtgcaccc actctgcttt gactgagcag actggtgagc agactggtgg gatctgtgcc     2880

cagagatggg actgggaggg cccacttcag ggttctcctc tcccctctaa ggccgaagaa     2940

gggtccttcc ctctccccaa gacttggtgt cctttccctc cactccttcc tgccacctgc     3000

tgctgctgct gctgctaatc ttcagggcac tgctgctgcc tttagtcgct gaggaaaaat     3060

aaagacaaat gctgcgccct tccccaaaaa aaaaaaa                              3097


<210> 47
<211> 92
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210> 48
<211> 1135
<212> DNA
<213> Homo sapiens

<400> 48
gggcagaggg aataagaggc tgcctctgcc caccagtcct gccgcccagg acccgcagca       60

gagacgacgc ctgcagcaag gagaccagga aggggtgaga caaggaagag gatgtctgag      120

ctggagaagg ccatggtggc cctcatcgac gttttccacc aatattctgg aagggaggga      180

gacaagcaca agctgaagaa atccgaactg aaggagctca tcaacaatga gctttcccat      240

ttcttagagg aaatcaaaga gcaggaggtt gtggacaaag tcatggaaac actggacaat      300

gatggagacg gcgaatgtga cttccaggaa ttcatggcct ttgttgccat ggttactact      360

gcctgccacg agttctttga acatgagtga gattagaaag cagccaaacc tttcctgtaa      420

cagagacggt catgcaagaa agcagacagc aagggcttgc agcctagtag gagctgagct      480

ttccagccgt gttgtagcta attaggaagc ttgatttgct ttgtgattga aaaattgaaa      540

acctctttcc aaaggctgtt ttaacggcct gcatcattct ttctgctata ttaggcctgt      600

gtgtaagctg actggcccca gggactcttg ttaacagtaa cttaggagtc aggtctcagt      660

gataaagcgt gcaccgtgca gcccgccatg gccgtgtaga ccctaacccg gagggaaccc      720

tgactacaga aattaccccg gggcaccctt aaaacttcca ctacctttaa aaaacaaagc      780

cttatccagc attatttgaa aacactgctg ttctttaaat gcgttcctca tccatgcaga      840

taacagctgg ttggccggtg tggccctgca agggcgtggt ggcttcggcc tgcttcccgg      900

gatgcgcctg atcaccaggt gaacgctcag cgctggcagc gctcctggaa aaagcaactc      960

catcagaact cgcaatccga gccagctctg ggggctccag cgtggcctcc gtgacccatg     1020

cgattcaagt cgcggctgca ggatccttgc ctccaacgtg cctccagcac atgcggcttc     1080

cgagggcact accgggggct ctgagccacc gcgagggcct gcgttcaata aaaag          1135


<210> 49
<211> 422
<212> PRT
<213> Homo sapiens

<400> 49
Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210> 50
<211> 1399
<212> DNA
<213> Homo sapiens

<400> 50
agggggaaga ctttaactag gggcgcgcag atgtgtgagg ccttttattg tgagagtgga       60

cagacatccg agatttcaga gccccatatt cgagccccgt ggaatcccgc ggcccccagc      120

cagagccagc atgcagaaca gtcacagcgg agtgaatcag ctcggtggtg tctttgtcaa      180

cgggcggcca ctgccggact ccacccggca gaagattgta gagctagctc acagcggggc      240

ccggccgtgc gacatttccc gaattctgca ggtgtccaac ggatgtgtga gtaaaattct      300

gggcaggtat tacgagactg gctccatcag acccagggca atcggtggta gtaaaccgag      360

agtagcgact ccagaagttg taagcaaaat agcccagtat aagcgggagt gcccgtccat      420

ctttgcttgg gaaatccgag acagattact gtccgagggg gtctgtacca acgataacat      480

accaagcgtg tcatcaataa acagagttct tcgcaacctg gctagcgaaa agcaacagat      540

gggcgcagac ggcatgtatg ataaactaag gatgttgaac gggcagaccg gaagctgggg      600

cacccgccct ggttggtatc cggggacttc ggtgccaggg caacctacgc aagatggctg      660

ccagcaacag gaaggagggg gagagaatac caactccatc agttccaacg gagaagattc      720

agatgaggct caaatgcgac ttcagctgaa gcggaagctg caaagaaata gaacatcctt      780

tacccaagag caaattgagg ccctggagaa agagtttgag agaacccatt atccagatgt      840

gtttgcccga gaaagactag cagccaaaat agatctacct gaagcaagaa tacaggtatg      900

gttttctaat cgaagggcca aatggagaag agaagaaaaa ctgaggaatc agagaagaca      960

ggccagcaac acacctagtc atattcctat cagcagtagt ttcagcacca gtgtctacca     1020

accaattcca caacccacca caccggtttc ctccttcaca tctggctcca tgttgggccg     1080

aacagacaca gccctcacaa acacctacag cgctctgccg cctatgccca gcttcaccat     1140

ggcaaataac ctgcctatgc aacccccagt ccccagccag acctcctcat actcctgcat     1200

gctgcccacc agcccttcgg tgaatgggcg gagttatgat acctacaccc ccccacatat     1260

gcagacacac atgaacagtc agccaatggg cacctcgggc accacttcaa caggactcat     1320

ttcccctggt gtgtcagttc cagttcaagt tcccggaagt gaacctgata tgtctcaata     1380

ctggccaaga ttacagtaa                                                  1399


<210> 51
<211> 1621
<212> PRT
<213> Homo sapiens

<400> 51
Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu 
            580                 585                 590         


Asn Lys Glu Leu Leu Lys Asp Val Glu Val Val Arg Pro Leu Glu Lys 
        595                 600                 605             


Glu Ala Val Gly Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr 
    610                 615                 620                 


Leu Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu 
625                 630                 635                 640 


Gly Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu 
                645                 650                 655     


Val Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys 
            660                 665                 670         


Glu Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala 
        675                 680                 685             


Leu Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu 
    690                 695                 700                 


Asp Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu 
705                 710                 715                 720 


Pro Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu 
                725                 730                 735     


Glu Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln 
            740                 745                 750         


Glu Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser 
        755                 760                 765             


Leu Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp 
    770                 775                 780                 


Leu Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu 
785                 790                 795                 800 


Asn Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu 
                805                 810                 815     


Ala Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala 
            820                 825                 830         


Gly Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro 
        835                 840                 845             


Leu Trp Thr Pro Glu Glu Ile Asn Gln Gly Ala Met Asn Pro Leu Glu 
    850                 855                 860                 


Lys Glu Ile Gln Glu Pro Leu Glu Ser Val Glu Val Asn Gln Glu Thr 
865                 870                 875                 880 


Phe Arg Leu Leu Glu Glu Glu Asn Gln Glu Ser Leu Arg Ser Leu Gly 
                885                 890                 895     


Ala Trp Asn Leu Glu Asn Leu Arg Ser Pro Glu Glu Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Glu Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Ile 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Ser Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Ala  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Pro Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Pro  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Leu Gly Lys Val Glu  Ser Glu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Gly Ser Gly Glu  Ile Pro Glu Gly Pro  Gln Glu Glu 
    1265                 1270                 1275             


Gly Glu  Glu Ser Arg Glu Glu  Ser Glu Glu Asp Glu  Leu Gly Glu 
    1280                 1285                 1290             


Thr Leu  Pro Asp Ser Thr Pro  Leu Gly Phe Tyr Leu  Arg Ser Pro 
    1295                 1300                 1305             


Thr Ser  Pro Arg Trp Asp Pro  Thr Gly Glu Gln Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gln Gly  Glu Thr Gly Lys Glu  Gly Trp Asp Pro Ala  Val Leu Ala 
    1325                 1330                 1335             


Ser Glu  Gly Leu Glu Ala Pro  Pro Ser Glu Lys Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Gly  Glu Glu Glu Cys Gly  Arg Asp Ser Asp Leu  Ser Glu Glu 
    1355                 1360                 1365             


Phe Glu  Asp Leu Gly Thr Glu  Ala Pro Phe Leu Pro  Gly Val Pro 
    1370                 1375                 1380             


Gly Glu  Val Ala Glu Pro Leu  Gly Gln Val Pro Gln  Leu Leu Leu 
    1385                 1390                 1395             


Asp Pro  Ala Ala Trp Asp Arg  Asp Gly Glu Ser Asp  Gly Phe Ala 
    1400                 1405                 1410             


Asp Glu  Glu Glu Ser Gly Glu  Glu Gly Glu Glu Asp  Gln Glu Glu 
    1415                 1420                 1425             


Gly Arg  Glu Pro Gly Ala Gly  Arg Trp Gly Pro Gly  Ser Ser Val 
    1430                 1435                 1440             


Gly Ser  Leu Gln Ala Leu Ser  Ser Ser Gln Arg Gly  Glu Phe Leu 
    1445                 1450                 1455             


Glu Ser  Asp Ser Val Ser Val  Ser Val Pro Trp Asp  Asp Ser Leu 
    1460                 1465                 1470             


Arg Gly  Ala Val Ala Gly Ala  Pro Lys Thr Ala Leu  Glu Thr Glu 
    1475                 1480                 1485             


Ser Gln  Asp Ser Ala Glu Pro  Ser Gly Ser Glu Glu  Glu Ser Asp 
    1490                 1495                 1500             


Pro Val  Ser Leu Glu Arg Glu  Asp Lys Val Pro Gly  Pro Leu Glu 
    1505                 1510                 1515             


Ile Pro  Ser Gly Met Glu Asp  Ala Gly Pro Gly Ala  Asp Ile Ile 
    1520                 1525                 1530             


Gly Val  Asn Gly Gln Gly Pro  Asn Leu Glu Gly Lys  Ser Gln His 
    1535                 1540                 1545             


Val Asn  Gly Gly Val Met Asn  Gly Leu Glu Gln Ser  Glu Glu Val 
    1550                 1555                 1560             


Gly Gln  Gly Met Pro Leu Val  Ser Glu Gly Asp Arg  Gly Ser Pro 
    1565                 1570                 1575             


Phe Gln  Glu Glu Glu Gly Ser  Ala Leu Lys Thr Ser  Trp Ala Gly 
    1580                 1585                 1590             


Ala Pro  Val His Leu Gly Gln  Gly Gln Phe Leu Lys  Phe Thr Gln 
    1595                 1600                 1605             


Arg Glu  Gly Asp Arg Glu Ser  Trp Ser Ser Gly Glu  Asp 
    1610                 1615                 1620     


<210> 52
<211> 5591
<212> DNA
<213> Homo sapiens

<400> 52
gctactccca ccccgccccg ccccgtcatt gtccccgtcg gtctcttttc tcttccgtcc       60

taaaagctct gcgagccgct cccttctccc ggtgccccgc gtctgtccat cctcagtggg      120

tcagacgagc aggatggagg gctgcatggg ggaggagtcg tttcagatgt gggagctcaa      180

tcggcgcctg gaggcctacc tggcccgggt caaggcgctg gaggagcaga atgagctgct      240

cagcgcggag ctcggggggc tccgggcaca atccgcggac acctcctggc gggcgcatgc      300

cgacgacgag ctggcggccc tgcgggccct cgttgaccaa cgctggcggg agaagcacgc      360

ggccgaggtg gcgcgcgaca acctggctga agagctggag ggcgtggcag gccgatgcca      420

gcagctgcgg ctggcccggg agcggacgac ggaggaggta gcccgcaacc ggcgcgccgt      480

cgaggcagag aaatgcgccc gggcctggct gagtagccag gtggcagagc tggagcgcga      540

gctagaggct ctacgcgtgg cgcacgagga ggagcgcgtc ggcctgaacg cgcaggctgc      600

ctgtgccccc cgctgccccg cgccgccccg cgggcctccc gcgccggccc cggaggtaga      660

ggagctggca aggcgactgg gcgaggcgtg gcgcggggca gtgcgcggct accaggagcg      720

cgtggcacac atggagacgt cgctgggcca ggcccgcgag cggctgggcc gggcggtgca      780

gggtgcccgc gagggccgcc tggagctgca gcagctccag gctgagcgcg gaggcctcct      840

ggagcgcagg gcagcgttgg aacagaggtt ggagggccgc tggcaggagc ggctgcgggc      900

tactgaaaag ttccagctgg ctgtggaggc cctggagcag gagaaacagg gcctacagag      960

ccagatcgct caggtcctgg aaggtcggca gcagctggcg cacctcaaga tgtccctcag     1020

cctggaggtg gccacgtaca ggaccctcct ggaggctgag aactcccggc tgcaaacacc     1080

tggcggtggc tccaagactt ccctcagctt tcaggacccc aagctggagc tgcaattccc     1140

taggacccca gagggccggc gtcttggatc tttgctccca gtcctgagcc caacttccct     1200

cccctcaccc ttgcctgcta cccttgagac acctgtgcca gcctttctta agaaccaaga     1260

attcctccag gcccgtaccc ctaccttggc cagcaccccc atccccccca cacctcaggc     1320

accctctcct gctgtagatg cagagatcag agcccaggat gctcctctct ctctgctcca     1380

gacacagggt gggaggaaac aggctccaga gcccctgcgg gctgaagcca gggtggccat     1440

tcctgccagc gtcctgcctg gaccagagga gcctgggggc cagcggcaag aggccagtac     1500

aggccagtcc ccagaggacc atgcctcctt ggcaccaccc ctcagccctg accactccag     1560

tttagaggct aaggatggag aatccggtgg gtctagagtg ttcagcatat gccgagggga     1620

aggtgaaggg caaatctggg ggttggtaga gaaagaaaca gccatagagg gcaaagtggt     1680

aagcagcttg cagcaggaaa tatgggaaga agaggatcta aacaggaagg aaatccagga     1740

ctcccaggtt cctttggaaa aagaaaccct gaagtctctg ggagaggaga ttcaagagtc     1800

actgaagact ctggaaaacc agagccatga gacactagaa agggagaatc aagaatgtcc     1860

gaggtcttta gaagaagact tagaaacact aaaaagtcta gaaaaggaaa ataaagagct     1920

attaaaggat gtggaggtag tgagacctct agaaaaagag gctgtaggcc aacttaagcc     1980

tacaggaaaa gaggacacac agacattgca atccctgcaa aaggagaatc aagaactaat     2040

gaaatctctt gaaggtaatc tagagacatt tttatttcca ggaacggaaa atcaagaatt     2100

agtaagttct ctgcaagaga acttagagtc attgacagct ctggaaaagg agaatcaaga     2160

gccactgaga tctccagaag taggggatga ggaggcactg agacctctga caaaggagaa     2220

tcaggaaccc ctgaggtctc ttgaagatga gaacaaagag gcctttagat ctctagaaaa     2280

agagaaccag gagccactga agactctaga agaagaggac cagagtattg tgagacctct     2340

agaaacagag aatcacaaat cactgaggtc tttagaagaa caggaccaag agacattgag     2400

aactcttgaa aaagagactc aacagcgacg gaggtctcta ggggaacagg atcagatgac     2460

attaagaccc ccagaaaaag tggatctaga accactgaag tctcttgacc aggagatagc     2520

tagacctctt gaaaatgaga atcaagagtt cttaaagtca ctcaaagaag agagcgtaga     2580

ggcagtaaaa tctttagaaa cagagatcct agaatcactg aagtctgcgg gacaagagaa     2640

cctggaaaca ctgaaatctc cagaaactca agcaccactg tggactccag aagaaataaa     2700

tcagggggca atgaatcctc tagaaaagga aattcaagaa ccactggagt ctgtggaagt     2760

gaaccaagag acattcagac tcctggaaga ggagaatcag gaatcattga gatctctggg     2820

agcatggaac ctggagaatt tgagatctcc agaggaggta gacaaggaaa gtcaaaggaa     2880

tctggaagag gaagagaacc tgggaaaggg agagtaccaa gagtcactga ggtctctgga     2940

ggaggaggga caggagctgc cgcagtctgc agatgtgcag aggtgggaag atacggtgga     3000

gaaggaccaa gaactggctc aggaaagccc tcctgggatg gctggagtgg aaaatgagga     3060

tgaggcagag ctgaatctga gggagcagga tggcttcact gggaaggagg aggtggtaga     3120

gcagggagag ctgaatgcca cagaggaggt ctggatccca ggcgaggggc acccagagag     3180

ccctgagccc aaagagcaga gaggcctggt tgagggagcc agtgtgaagg gaggggctga     3240

gggcctccag gaccctgaag ggcaatcaca acaggtgggg gccccaggcc tccaggctcc     3300

ccaggggctg ccagaggcga tagagcccct ggtggaagat gatgtggccc cagggggtga     3360

ccaagcctcc ccagaggtca tgttggggtc agagcctgcc atgggtgagt ctgctgcggg     3420

agctgagcca ggcccggggc agggggtggg agggctgggg gacccaggcc atctgaccag     3480

ggaagaggtg atggaaccac ccctggaaga ggagagtttg gaggcaaaga gggttcaggg     3540

cttggaaggg cctagaaagg acctagagga ggcaggtggt ctggggacag agttctccga     3600

gctgcctggg aagagcagag acccttggga gcctcccagg gagggtaggg aggagtcaga     3660

ggctgaggcc cccaggggag cagaggaggc gttccctgct gagaccctgg gccacactgg     3720

aagtgatgcc ccttcacctt ggcctctggg gtcagaggaa gctgaggagg atgtaccacc     3780

agtgctggtc tcccccagcc caacgtacac cccgatcctg gaagatgccc ctgggcctca     3840

gcctcaggct gaagggagtc aggaggctag ctggggggtg caggggaggg ctgaagccct     3900

ggggaaagta gagagcgagc aggaggagtt gggttctggg gagatccccg agggccccca     3960

ggaggaaggg gaggagagca gagaagagag cgaggaggat gagctcgggg agacccttcc     4020

agactccact cccctgggct tctacctcag gtcccccacc tcccccaggt gggaccccac     4080

tggagagcag aggccacccc ctcaagggga gactggaaag gagggctggg atcctgctgt     4140

cctggcttcc gagggccttg aggccccacc ctcagaaaag gaggaggggg aggagggaga     4200

agaggagtgt ggccgtgact ctgacctgtc agaagaattt gaggacctgg ggactgaggc     4260

accttttctt cctggggtcc ctggggaggt ggcagaacct ctgggccagg tgccccagct     4320

gctactggat cctgcagcct gggatcgaga tggggagtcc gatgggtttg cagatgagga     4380

agaaagtggg gaggagggag aggaggatca ggaggagggg agggagccag gggctgggcg     4440

gtgggggcca gggtcttctg ttggcagcct ccaggccctg agtagctccc agagagggga     4500

attcctggag tctgattctg tgagtgtcag tgtcccctgg gatgacagct tgaggggtgc     4560

agtggctggt gcccccaaga ctgccctgga aacggagtcc caggacagtg ctgagccttc     4620

tggctcagag gaagagtctg accctgtttc cttggagagg gaggacaaag tccctggccc     4680

tctagagatc cccagtggga tggaggatgc aggcccaggg gcagacatca ttggtgttaa     4740

tggccagggt cccaacttgg aggggaagtc acagcatgtg aatgggggag tgatgaacgg     4800

gctggagcag tctgaggaag tggggcaagg aatgccgcta gtctctgagg gagaccgagg     4860

gagccccttt caggaggagg aggggagtgc tctgaagacc tcttgggcag gggctcctgt     4920

tcacctgggc cagggtcagt tcctgaagtt cactcagagg gaaggagata gagagtcctg     4980

gtcctcaggg gaggactagg aaaagaccat ctgcccggca ctggggactt aggggtgcgg     5040

ggaggggaag gacgcctcca agcccgctcc ctgctcagga gcagcactct taacttacga     5100

tctcttgaca tatggtttct ggctgagagg cctggcccgc taaggtgaaa aggggtgtgg     5160

caaaggagcc tactccaaga atggaggctg taggaatata acctcccacc ctgcaaaggg     5220

aatctcttgc ctgctccatc tcataggcta agtcagctga atcccgatag tactaggtcc     5280

ccttccctcc gcatcccgtc agctggaaaa ggcctgtggc ccagaggctt ctccaaaggg     5340

agggtgacat gctggctttt gtgcccaagc tcaccagccc tgcgccacct cactgcagta     5400

gtgcaccatc tcactgcagt agcacgccct cctgggccgt ctggcctgtg gctaatggag     5460

gtgacggcac tcccatgtgc tgactccccc catccctgcc acgctgtggc cctgcctggc     5520

tagtccctgc ctgaataaag taatgcctcc gcttcaaaaa aaaaaaaaaa aaaaaaaaaa     5580

aaaaaaaaaa a                                                          5591


<210> 53
<211> 348
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Gln Pro Gly Ser Gly Cys Lys Ala Thr Thr Arg Cys Leu Glu 
1               5                   10                  15      


Gly Thr Ala Pro Pro Ala Met Ala Gln Ser Asp Ala Glu Ala Leu Ala 
            20                  25                  30          


Gly Ala Leu Asp Lys Asp Glu Gly Gln Ala Ser Pro Cys Thr Pro Ser 
        35                  40                  45              


Thr Pro Ser Val Cys Ser Pro Pro Ser Ala Ala Ser Ser Val Pro Ser 
    50                  55                  60                  


Ala Gly Lys Asn Ile Cys Ser Ser Cys Gly Leu Glu Ile Leu Asp Arg 
65                  70                  75                  80  


Tyr Leu Leu Lys Val Asn Asn Leu Ile Trp His Val Arg Cys Leu Glu 
                85                  90                  95      


Cys Ser Val Cys Arg Thr Ser Leu Arg Gln Gln Asn Ser Cys Tyr Ile 
            100                 105                 110         


Lys Asn Lys Glu Ile Phe Cys Lys Met Asp Tyr Phe Ser Arg Phe Gly 
        115                 120                 125             


Thr Lys Cys Ala Arg Cys Gly Arg Gln Ile Tyr Ala Ser Asp Trp Val 
    130                 135                 140                 


Arg Arg Ala Arg Gly Asn Ala Tyr His Leu Ala Cys Phe Ala Cys Phe 
145                 150                 155                 160 


Ser Cys Lys Arg Gln Leu Ser Thr Gly Glu Glu Phe Gly Leu Val Glu 
                165                 170                 175     


Glu Lys Val Leu Cys Arg Ile His Tyr Asp Thr Met Ile Glu Asn Leu 
            180                 185                 190         


Lys Arg Ala Ala Glu Asn Gly Asn Gly Leu Thr Leu Glu Gly Ala Val 
        195                 200                 205             


Pro Ser Glu Gln Asp Ser Gln Pro Lys Pro Ala Lys Arg Ala Arg Thr 
    210                 215                 220                 


Ser Phe Thr Ala Glu Gln Leu Gln Val Met Gln Ala Gln Phe Ala Gln 
225                 230                 235                 240 


Asp Asn Asn Pro Asp Ala Gln Thr Leu Gln Lys Leu Ala Asp Met Thr 
                245                 250                 255     


Gly Leu Ser Arg Arg Val Ile Gln Val Trp Phe Gln Asn Cys Arg Ala 
            260                 265                 270         


Arg His Lys Lys His Thr Pro Gln His Pro Val Pro Pro Ser Gly Ala 
        275                 280                 285             


Pro Pro Ser Arg Leu Pro Ser Ala Leu Ser Asp Asp Ile His Tyr Thr 
    290                 295                 300                 


Pro Phe Ser Ser Pro Glu Arg Ala Arg Met Val Thr Leu His Gly Tyr 
305                 310                 315                 320 


Ile Glu Ser His Pro Phe Ser Val Leu Thr Leu Pro Ala Leu Pro His 
                325                 330                 335     


Leu Pro Val Gly Ala Pro Gln Leu Pro Leu Ser Arg 
            340                 345             


<210> 54
<211> 2835
<212> DNA
<213> Homo sapiens

<400> 54
cccgccaccg accaggtgat ggcccagcca gggtccggct gcaaagcgac cacccgctgt       60

cttgaaggga ccgcgccgcc cgccatggct cagtctgacg ccgaggccct ggcaggagct      120

ctggacaagg acgagggtca ggcctcccca tgtacgccca gcacgccatc tgtctgctca      180

ccgccctctg ccgcctcctc cgtgccgtct gcaggcaaga acatctgctc cagctgcggc      240

ctcgagatcc tggaccgata tctgctcaag gtcaacaacc tcatctggca cgtgcggtgc      300

ctcgagtgct ccgtgtgtcg cacgtcgctg aggcagcaga acagctgcta catcaagaac      360

aaggagatct tctgcaagat ggactacttc agccgattcg ggaccaagtg tgcccggtgc      420

ggccgacaga tctacgccag cgactgggtg cggagagctc gcggcaacgc ctaccacctg      480

gcctgcttcg cctgcttctc gtgcaagcgc cagctgtcca ctggtgagga gttcggcctg      540

gtcgaggaga aggtgctctg ccgcatccac tacgacacca tgattgagaa cctcaagagg      600

gccgccgaga acgggaacgg cctcacgttg gagggggcag tgccctcgga acaggacagt      660

caacccaagc cggccaagcg cgcgcggacg tccttcaccg cggaacagct gcaggttatg      720

caggcgcagt tcgcgcagga caacaacccc gacgctcaga cgctgcagaa gctggcggac      780

atgacgggcc tcagccggag agtcatccag gtgtggtttc aaaactgccg ggcgcgtcat      840

aaaaagcaca cgccgcaaca cccagtgccg ccctcggggg cgcccccgtc ccgccttccc      900

tccgccctgt ccgacgacat ccactacacc ccgttcagca gccccgagcg ggcgcgcatg      960

gtcaccctgc acggctacat tgagagtcat cctttttcag tactaacgct gccggcactt     1020

ccgcatctgc ccgtgggcgc cccacagctg cccctcagcc gctgagatcc agtgtccaag     1080

ctgcggccag gagtccaccc acctccgcat ccacccccgt ccgccatcct gcccaccacc     1140

aggtcggttc ccgaggcctg gcctttccct ctcctgctga gaaccagaac ccaccaggag     1200

caccacagag tcctcctctt ggaaggcaga actccctgaa atctggaatc agggtggaaa     1260

cagcctgttt ttcccattta aacaggagtc ctcttcaact tcagctgatt acaataacaa     1320

aaggcggaat tgaattgtgc gatgccaacg gccttctcat ttacaggttt ttttccccca     1380

cattggcctt tatttactac ttccttggaa ccatctctga attctgaata gctgacaacc     1440

cccaatgtta tccactctgt tgcttttgtc tggaaaactc tacagtgttt gtgggatgtc     1500

cccaaaggta agctatgttc taattttatc atttccatct gtctggttat gtcaagttaa     1560

ttcagaaaga gaagagacag tgaccaaccc tgagaggcct aatagggcag agatggaggc     1620

ctgcccagac taggaggcag cggggataga cagggaatgg ggagaagaaa gacccccatt     1680

ggtttggaaa tcaaggagag ggcggtgaca tattggacca gaagaggcac tagccatttt     1740

aaggagagga aagagaaaac tctggggtca gggagagacc ctacccccac ctaattatcc     1800

agcatatatg taagaaacat agcagcgatg gtattcgatc tgtgccatga ctcttctgaa     1860

tgtttggaca ggttagagtt ggggacccct gttggccact tgttgacctc tcatagtggt     1920

gcttgggcca ggtcttctca atggaagggg aatcccttat aggggagagg gaacagagcc     1980

cagtgaaatg gcagtcagaa tgttaaccct ggatccatct ctaagtagag agagggtgcc     2040

cattgcctag gtgagtgtgc caagctcagg attccaactg gtgcctctga gcttcccaat     2100

caatacttcc tggagccagc cccacccacc cctgagaaca gaggtcagac acagctgcgt     2160

aacatccatc ctgctacaac tcttccaccc caaacaaaag ggctcaggct acacacgacc     2220

atgatttatg ttttcagggg atgcccattt gtcccaagct tatcctgtaa ttctagaatt     2280

acctggtgtc ctgatgcatt ttccactaga ggttgctaat cagcatgttt tagcccaagt     2340

ccaccttcct gctgtggtta acctgttatg ttgcttttgg aaggagactc taagacaggg     2400

aaagcaagtt catggtacat acgcagccat tgtctctgtt tttacccatg gcagacattg     2460

ctaatcaatg gcagctctat ttcactgagt ctggataagg tttcagagtt caaatgcttg     2520

acgttggcac ttaacatgaa agcctatagg tcattcttgc tctgggatct acaggcaggg     2580

taggcacagg tgcagcctaa gaagggaacc tgcttcctct cccttccaaa gacagtgaca     2640

gctgactgag ggcaaagagc aggcaccact cagaacgtgg tgagtacagc tcagctcagc     2700

actcagtcag tggtaacttg tgcccagccc tgtgctaggc gctgacatta acaggagcaa     2760

ccagggccca attcctggcc ttggagctca aatctttcct ttgatttttg ctcctgatca     2820

tcaaggcccc agtgg                                                      2835


<210> 55
<211> 356
<212> PRT
<213> Homo sapiens

<400> 55
Met Gln Ile Leu Ser Arg Cys Gln Gly Leu Met Ser Glu Glu Cys Gly 
1               5                   10                  15      


Arg Thr Thr Ala Leu Ala Ala Gly Arg Thr Arg Lys Gly Ala Gly Glu 
            20                  25                  30          


Glu Gly Leu Val Ser Pro Glu Gly Ala Gly Asp Glu Asp Ser Cys Ser 
        35                  40                  45              


Ser Ser Ala Pro Leu Ser Pro Ser Ser Ser Pro Arg Ser Met Ala Ser 
    50                  55                  60                  


Gly Ser Gly Cys Pro Pro Gly Lys Cys Val Cys Asn Ser Cys Gly Leu 
65                  70                  75                  80  


Glu Ile Val Asp Lys Tyr Leu Leu Lys Val Asn Asp Leu Cys Trp His 
                85                  90                  95      


Val Arg Cys Leu Ser Cys Ser Val Cys Arg Thr Ser Leu Gly Arg His 
            100                 105                 110         


Thr Ser Cys Tyr Ile Lys Asp Lys Asp Ile Phe Cys Lys Leu Asp Tyr 
        115                 120                 125             


Phe Arg Arg Tyr Gly Thr Arg Cys Ser Arg Cys Gly Arg His Ile His 
    130                 135                 140                 


Ser Thr Asp Trp Val Arg Arg Ala Lys Gly Asn Val Tyr His Leu Ala 
145                 150                 155                 160 


Cys Phe Ala Cys Phe Ser Cys Lys Arg Gln Leu Ser Thr Gly Glu Glu 
                165                 170                 175     


Phe Ala Leu Val Glu Glu Lys Val Leu Cys Arg Val His Tyr Asp Cys 
            180                 185                 190         


Met Leu Asp Asn Leu Lys Arg Glu Val Glu Asn Gly Asn Gly Ile Ser 
        195                 200                 205             


Val Glu Gly Ala Leu Leu Thr Glu Gln Asp Val Asn His Pro Lys Pro 
    210                 215                 220                 


Ala Lys Arg Ala Arg Thr Ser Phe Thr Ala Asp Gln Leu Gln Val Met 
225                 230                 235                 240 


Gln Ala Gln Phe Ala Gln Asp Asn Asn Pro Asp Ala Gln Thr Leu Gln 
                245                 250                 255     


Lys Leu Ala Glu Arg Thr Gly Leu Ser Arg Arg Val Ile Gln Val Trp 
            260                 265                 270         


Phe Gln Asn Cys Arg Ala Arg His Lys Lys His Val Ser Pro Asn His 
        275                 280                 285             


Ser Ser Ser Thr Pro Val Thr Ala Ala Pro Pro Ser Arg Leu Ser Pro 
    290                 295                 300                 


Pro Met Leu Glu Glu Met Ala Tyr Ser Ala Tyr Val Pro Gln Asp Gly 
305                 310                 315                 320 


Thr Met Leu Thr Ala Leu His Ser Tyr Met Asp Ala His Ser Pro Thr 
                325                 330                 335     


Thr Leu Gly Leu Gln Pro Leu Leu Pro His Ser Met Thr Gln Leu Pro 
            340                 345                 350         


Ile Ser His Thr 
        355     


<210> 56
<211> 2411
<212> DNA
<213> Homo sapiens

<400> 56
agcggcaaga ggctagcggc tggaccactt gtgctggagt ggtaaagaac tatcatgaat       60

ccatttactg aaagtgtcca tttctgaact caccctaaag aggacaaaca ccgcaaagta      120

gttaaaagtc aggcattcgc gtcggacgtc tgggtttgaa ttctgccctg gcttgactgg      180

aaacgcttcc cctatttctt ccgtagcgga ccgggagagc ttactggcgc tctgcgaacc      240

ggctggaaag aaacaccgag tcactcgtac agactcttgg tcgcagaact tggctttccg      300

ctattggtcc tccagaaccg cttgaaacaa ctggccccag ctggcgcatc agaccgcagt      360

gaggaatgcc gcggggcggg tggcgaaggc agggtctgcc cgccagtgga ttcccgggtg      420

tcccgcgtgg agcaggcttg cccagctggg aagcccatca aacctcagtc ttggcccaca      480

gtgggagaga gaccagtggg tcccagacgg aggccatcgc ccgcttttgg cgacctccac      540

tggcgtgaat aaaagcaccc ctctcttacc ctcagaaact gtgggtagca aggtataaaa      600

cggagtctgg gaccggtaag tcccaaggtg agcccgtata cagctctgcc atctctgagg      660

ggttatgcag attctgagca ggtgtcaggg gctcatgtca gaggagtgcg ggcggactac      720

agccctggcg gccgggagga ctcgcaaagg cgccggggaa gagggactgg tgagccccga      780

gggagcgggg gacgaggact cgtgctcctc ctcggccccg ctgtccccgt cgtcctcgcc      840

ccggtccatg gcctcgggct ccggctgccc tcctggcaag tgtgtgtgca acagttgcgg      900

cctggagatc gtggacaaat accttctcaa ggtgaatgac ctatgctggc atgtccggtg      960

tctctcctgc agtgtttgca gaacctccct aggaaggcac accagctgtt atattaaaga     1020

caaagacatt ttctgcaaac ttgattattt cagaaggtat ggaactcgct gctctcgatg     1080

tgggagacac atccattcta ctgactgggt ccggagagcc aaggggaatg tctatcactt     1140

ggcatgcttt gcctgctttt cctgcaaaag gcaactttcc acaggagagg agtttgcttt     1200

ggtggaagag aaagtcctct gcagagtaca ttatgactgc atgctggata atttaaaaag     1260

agaagtagaa aatgggaatg ggattagtgt ggaaggtgcc ctcctcacag agcaagatgt     1320

taaccatcca aaaccagcaa aaagagctcg gaccagcttt acagcagatc agcttcaggt     1380

tatgcaagca caatttgctc aggacaacaa cccagatgca cagacactcc agaaattggc     1440

agaaaggaca ggcttgagca gacgtgtgat acaggtgtgg tttcagaatt gtagagcacg     1500

ccacaagaaa cacgtcagtc ctaatcactc atcctccacc ccagtcacag cagccccacc     1560

ctccaggctg tctccaccca tgttagaaga aatggcttat tctgcctacg tgccccaaga     1620

tggaacgatg ttaactgcgc tgcatagtta tatggatgct cattcaccaa caactcttgg     1680

actccagccc ttgttacccc attcaatgac acaactgcca ataagtcata cctaattctt     1740

ttttcaggga tagacttgat taaggatata aatttgtcat ttattatgta taaaatacca     1800

ttgaaaagat attactgtta attttttatt taacacctaa agcatttcca acatcacttt     1860

gctgcccagg tatgtatcta tagttggcct gcaagacact tttattaatt cttcattttt     1920

tgtaaaactt atgtttacaa gaagaaaaca aatcaaaaca ttttttgtat tgtctggaaa     1980

tagttcactc tagtgtgtat ctgttaattt atttgtcatc aaaagagcac tttgcctaaa     2040

agaaaggact gacaagtgtg caaaatgttt acaatctttt gtgaaattgt agtttatcat     2100

tagtttgtat ctgtaagtta ttgtaataaa tattacctgt attttttgtt atatacaact     2160

ttatactttg aagcttgtat ctgtgaattt gcaactgaaa tttattttgc caatgttttc     2220

tgaatgaact gaataaagct tctgttgtag catgccatgc aaacacatta ttgtgtttgt     2280

ggttgatgaa ttatggctgt aaataacact atagtttaat aagcccacca ttctgagttt     2340

attaaacatt ttccattctt gtgaaaattt caaaaaaaaa aaaaaaaaaa aaagaaaaaa     2400

aaaaaaaaaa a                                                          2411


<210> 57
<211> 682
<212> PRT
<213> Homo sapiens

<400> 57
Met Gln Leu Glu His Cys Leu Ser Pro Ser Ile Met Leu Ser Lys Lys 
1               5                   10                  15      


Phe Leu Asn Val Ser Ser Ser Tyr Pro His Ser Gly Gly Ser Glu Leu 
            20                  25                  30          


Val Leu His Asp His Pro Ile Ile Ser Thr Thr Asp Asn Leu Glu Arg 
        35                  40                  45              


Ser Ser Pro Leu Lys Lys Ile Thr Arg Gly Met Thr Asn Gln Ser Asp 
    50                  55                  60                  


Thr Asp Asn Phe Pro Asp Ser Lys Asp Ser Pro Gly Asp Val Gln Arg 
65                  70                  75                  80  


Ser Lys Leu Ser Pro Val Leu Asp Gly Val Ser Glu Leu Arg His Ser 
                85                  90                  95      


Phe Asp Gly Ser Ala Ala Asp Arg Tyr Leu Leu Ser Gln Ser Ser Gln 
            100                 105                 110         


Pro Gln Ser Ala Ala Thr Ala Pro Ser Ala Met Phe Pro Tyr Pro Gly 
        115                 120                 125             


Gln His Gly Pro Ala His Pro Ala Phe Ser Ile Gly Ser Pro Ser Arg 
    130                 135                 140                 


Tyr Met Ala His His Pro Val Ile Thr Asn Gly Ala Tyr Asn Ser Leu 
145                 150                 155                 160 


Leu Ser Asn Ser Ser Pro Gln Gly Tyr Pro Thr Ala Gly Tyr Pro Tyr 
                165                 170                 175     


Pro Gln Gln Tyr Gly His Ser Tyr Gln Gly Ala Pro Phe Tyr Gln Phe 
            180                 185                 190         


Ser Ser Thr Gln Pro Gly Leu Val Pro Gly Lys Ala Gln Val Tyr Leu 
        195                 200                 205             


Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met 
    210                 215                 220                 


Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn 
225                 230                 235                 240 


Ile Ser Gly Leu Asp Pro Thr Ala His Tyr Asn Ile Phe Val Asp Val 
                245                 250                 255     


Ile Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val 
            260                 265                 270         


Pro Cys Gly Lys Ala Asp Thr Asn Val Gln Gly Asn Arg Val Tyr Met 
        275                 280                 285             


His Pro Asp Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Ile 
    290                 295                 300                 


Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn 
305                 310                 315                 320 


Asn Gly Gln Met Val Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg 
                325                 330                 335     


Leu His Val Val Glu Val Asn Glu Asp Gly Thr Glu Asp Thr Ser Gln 
            340                 345                 350         


Pro Gly Arg Val Gln Thr Phe Thr Phe Pro Glu Thr Gln Phe Ile Ala 
        355                 360                 365             


Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His 
    370                 375                 380                 


Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Thr Ile Tyr Thr 
385                 390                 395                 400 


Gly Cys Asp Met Asp Arg Leu Thr Pro Ser Pro Asn Asp Ser Pro Arg 
                405                 410                 415     


Ser Gln Ile Val Pro Gly Ala Arg Tyr Ala Met Ala Gly Ser Phe Leu 
            420                 425                 430         


Gln Asp Gln Phe Val Ser Asn Tyr Ala Lys Ala Arg Phe His Pro Gly 
        435                 440                 445             


Ala Gly Ala Gly Pro Gly Pro Gly Thr Asp Arg Ser Val Pro His Thr 
    450                 455                 460                 


Asn Gly Leu Leu Ser Pro Gln Gln Ala Glu Asp Pro Gly Ala Pro Ser 
465                 470                 475                 480 


Pro Gln Arg Trp Phe Val Thr Pro Ala Asn Asn Arg Leu Asp Phe Ala 
                485                 490                 495     


Ala Ser Ala Tyr Asp Thr Ala Thr Asp Phe Ala Gly Asn Ala Ala Thr 
            500                 505                 510         


Leu Leu Ser Tyr Ala Ala Ala Gly Val Lys Ala Leu Pro Leu Gln Ala 
        515                 520                 525             


Ala Gly Cys Thr Gly Arg Pro Leu Gly Tyr Tyr Ala Asp Pro Ser Gly 
    530                 535                 540                 


Trp Gly Ala Arg Ser Pro Pro Gln Tyr Cys Gly Thr Lys Ser Gly Ser 
545                 550                 555                 560 


Val Leu Pro Cys Trp Pro Asn Ser Ala Ala Ala Ala Ala Arg Met Ala 
                565                 570                 575     


Gly Ala Asn Pro Tyr Leu Gly Glu Glu Ala Glu Gly Leu Ala Ala Glu 
            580                 585                 590         


Arg Ser Pro Leu Pro Pro Gly Ala Ala Glu Asp Ala Lys Pro Lys Asp 
        595                 600                 605             


Leu Ser Asp Ser Ser Trp Ile Glu Thr Pro Ser Ser Ile Lys Ser Ile 
    610                 615                 620                 


Asp Ser Ser Asp Ser Gly Ile Tyr Glu Gln Ala Lys Arg Arg Arg Ile 
625                 630                 635                 640 


Ser Pro Ala Asp Thr Pro Val Ser Glu Ser Ser Ser Pro Leu Lys Ser 
                645                 650                 655     


Glu Val Leu Ala Gln Arg Asp Cys Glu Lys Asn Cys Ala Lys Asp Ile 
            660                 665                 670         


Ser Gly Tyr Tyr Gly Phe Tyr Ser His Ser 
        675                 680         


<210> 58
<211> 4006
<212> DNA
<213> Homo sapiens

<400> 58
gtcgctacca ggagccaggt gattatccta attaatgtct atctaattaa attactgtca       60

gcagctaacc aatggcagga gccgtttcat cggctgcaca agcagcaaga tcaaaagtga      120

gccttttctg attgctgcat agtgtcaatt ggccaatctc ttctcccagg gaaaaaaaaa      180

agtaaatcaa acctttgaga agcatttgct ggttgaagtg ctttctgtct agtgaggggg      240

tctgtggatt tctagtttat gataaatagg actttaaaaa ccagggacgg gagggcgagt      300

gttcaggttc tagagctatg cagctggagc actgcctttc tccttctatc atgctctcca      360

agaaatttct caatgtgagc agcagctacc cacattcagg cggatccgag cttgtcttgc      420

acgatcatcc cattatctcg accactgaca acctggagag aagttcacct ttgaaaaaaa      480

ttaccagggg gatgacgaat cagtcagata cagacaattt tcctgactcc aaggactcac      540

caggggacgt ccagagaagt aaactctctc ctgtcttgga cggggtctct gagcttcgtc      600

acagtttcga tggctctgct gcagatcgct acctcctctc tcagtccagc cagccacagt      660

ctgcggccac tgctcccagt gccatgttcc cgtaccccgg ccagcacgga ccggcgcacc      720

ccgccttctc catcggcagc cctagccgct acatggccca ccacccggtc atcaccaacg      780

gagcctacaa cagcctcctg tccaactcct cgccgcaggg ataccccacg gccggctacc      840

cctacccaca gcagtacggc cactcctacc aaggagctcc gttctaccag ttctcctcca      900

cccagccggg gctggtgccc ggcaaagcac aggtgtacct gtgcaacagg cccctttggc      960

tgaaatttca ccggcaccaa acggagatga tcatcaccaa acagggaagg cgcatgtttc     1020

cttttttaag ttttaacatt tctggtctcg atcccacggc tcattacaat atttttgtgg     1080

atgtgatttt ggcggatccc aatcactgga ggtttcaagg aggcaaatgg gttccttgcg     1140

gcaaagcgga caccaatgtg caaggaaatc gggtctatat gcatccggat tcccccaaca     1200

ctggggctca ctggatgcgc caagaaatct cttttggaaa attaaaactt acgaacaaca     1260

aaggagcttc aaataacaat gggcagatgg tggttttaca gtccttgcac aagtaccagc     1320

cccgcctgca tgtggtggaa gtgaacgagg acggcacgga ggacactagc cagcccggcc     1380

gcgtgcagac gttcactttc cctgagactc agttcatcgc cgtcaccgcc taccagaaca     1440

cggatattac acaactgaaa atagatcaca acccttttgc aaaaggattt cgggataatt     1500

atgacacgat ctacaccggc tgtgacatgg accgcctgac cccctcgccc aacgactcgc     1560

cgcgctcgca gatcgtgccc ggggcccgct acgccatggc cggctctttc ctgcaggacc     1620

agttcgtgag caactacgcc aaggcccgct tccacccggg cgcgggcgcg ggccccgggc     1680

cgggtacgga ccgcagcgtg ccgcacacca acgggctgct gtcgccgcag caggccgagg     1740

acccgggcgc gccctcgccg caacgctggt ttgtgacgcc ggccaacaac cggctggact     1800

tcgcggcctc ggcctatgac acggccacgg acttcgcggg caacgcggcc acgctgctct     1860

cttacgcggc ggcgggcgtg aaggcgctgc cgctgcaggc tgcaggctgc actggccgcc     1920

cgctcggcta ctacgccgac ccgtcgggct ggggcgcccg cagtcccccg cagtactgcg     1980

gcaccaagtc gggctcggtg ctgccctgct ggcccaacag cgccgcggcc gccgcgcgca     2040

tggccggcgc caatccctac ctgggcgagg aggccgaggg cctggccgcc gagcgctcgc     2100

cgctgccgcc cggcgccgcc gaggacgcca agcccaagga cctgtccgat tccagctgga     2160

tcgagacgcc ctcctcgatc aagtccatcg actccagcga ctcggggatt tacgagcagg     2220

ccaagcggag gcggatctcg ccggccgaca cgcccgtgtc cgagagttcg tccccgctca     2280

agagcgaggt gctggcccag cgggactgcg agaagaactg cgccaaggac attagcggct     2340

actatggctt ctactcgcac agctaggccg cccctgcccg cccggccccg ccgcggcccg     2400

gacccccagc cagcccctca cagctcttcc ccagctccgc ctccccacac tcctccttgc     2460

gcacccactc attttatttg accctcgatg gccgtctgca gcgaataagt gcaggtctcc     2520

gagcgtgatt ttaacctttt ttgcacagca gtctctgcaa ttagctcacc gaccttcaac     2580

tttgctgtaa accttttggt tttcctactt actcttcttc tgtggagtta tcctcctaca     2640

attcccctcc ccctcgtctt tctcttacct cctacttctc tttcttgtaa tgaaactctt     2700

cacctttagg agacctgggc agtcctgtca ggcagcagcg attccgaccc gccaagtctc     2760

ggcctccaca ttaaccatag gatgttgact ctagaacctg gacccaccca gcgcgtcctt     2820

tcttatcccc gagtggatgg atggatggat ggatggtagg gatgttaata attttagtgg     2880

aacaaagcct gtgaaatgat tgtacatagt gttaatttat tgtaacgaat ggctagtttt     2940

tattctcgtc aaggcacaaa accagttcat gcttaacctt tttttccttt cctttctttg     3000

cttttctttc tctcctctca tactttctct tctctctctt ttaattttct tgtgagataa     3060

tattctaaga ggctctagaa acatgaaata ctcagtagtg atgggtttcc cacttctcct     3120

caatccgttg catgaaataa ttactatgtg ccctaatgca cacaaatagc taaggagaat     3180

ccacccaaac acctttaaag gataggtgtc tgttcatagg caagtcgatt aagtggcatg     3240

atgcctgcaa agcaaagtca actggagttg tatgttcccc ccaccttcta aatagaatag     3300

ctcgacatca gcaatattat tttgccttat ttgtttttcc ccaaagtgcc aaatccatta     3360

ctggtctgtg caggtgccaa atatgctgac aaactgtttc tgaatatctt tcagtacccc     3420

ttcaccttta tatgctgtaa atctttgtaa tgaatactct attaatgata tagatgactg     3480

aattgttggt aactatagtg tagtctagtg aagatgaatt gtgtgagttg tatattttac     3540

tgcattttag ttttgaaaat gacttcccca ccacctagaa acagctgaaa tttgacttcc     3600

ttgggagaac actagcatta atgcaagtaa gactgatttt cccctaagtc ttgttatatt     3660

tgataaggag cattaatccc cctggaaata gattagtagg atttctaatg ttgtgtagca     3720

aacctatact tttttgtatt taaaaattaa tgtgaaatat gcatcataca caatattcaa     3780

tctagattcc agtccatggg gggatttttc ctaataggaa ttcagggtct aaacgtgtgt     3840

atattttggc tcttctgtaa atctaatgtt gtgattttta tatttgtttc gttttgtctg     3900

tgaactgaat aatttataca agaacacact ccattgagaa acgttttgtt ttttgctcgt     3960

ttgtatcgtc tgtgtataac aagtaaaata aacctggtaa aaacgc                    4006


<210> 59
<211> 542
<212> PRT
<213> Homo sapiens

<400> 59
Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
            420                 425                 430         


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
        435                 440                 445             


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
    450                 455                 460                 


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
465                 470                 475                 480 


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
                485                 490                 495     


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
            500                 505                 510         


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
        515                 520                 525             


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
    530                 535                 540         


<210> 60
<211> 1873
<212> DNA
<213> Homo sapiens

<400> 60
gatagtaact tgcagtttca gagcacatgc acactgtcag ggctagcctg cctgcttacg       60

cgcgctgcgg attgttgctc cgttgtacct gctggggaat tcacctcgtt actgcttgat      120

atcttccacc ccttacaaaa tcagaaaagt tgtgttttct aataccaaag aggaggtttg      180

gctttctgtg ggtgattccc agacactgaa gtgcaaagaa gagaccctcc tagaaaagta      240

aaatatgact aaaagcaatg gagaagagcc caagatgggg ggcaggatgg agagattcca      300

gcagggagtc cgtaaacgca cacttttggc caagaagaaa gtgcagaaca ttacaaagga      360

ggatgttaaa agttacctgt ttcggaatgc ttttgtgctg ctcacagtca ccgctgtcat      420

tgtgggtaca atccttggat ttaccctccg accatacaga atgagctacc gggaagtcaa      480

gtacttctcc tttcctgggg aacttctgat gaggatgtta cagatgctgg tcttaccact      540

tatcatctcc agtcttgtca caggaatggc ggcgctagat agtaaggcat cagggaagat      600

gggaatgcga gctgtagtct attatatgac taccaccatc attgctgtgg tgattggcat      660

aatcattgtc atcatcatcc atcctgggaa gggcacaaag gaaaacatgc acagagaagg      720

caaaattgta cgagtgacag ctgcagatgc cttcctggac ttgatcagga acatgttccc      780

tccaaatctg gtagaagcct gctttaaaca gtttaaaacc aactatgaga agagaagctt      840

taaagtgccc atccaggcca acgaaacgct tgtgggtgct gtgataaaca atgtgtctga      900

ggccatggag actcttaccc gaatcacaga ggagctggtc ccagttccag gatctgtgaa      960

tggagtcaat gccctgggtc tagttgtctt ctccatgtgc ttcggttttg tgattggaaa     1020

catgaaggaa caggggcagg ccctgagaga gttctttgat tctcttaacg aagccatcat     1080

gagactggta gcagtaataa tgtggtatgc ccccgtgggt attctcttcc tgattgctgg     1140

gaagattgtg gagatggaag acatgggtgt gattgggggg cagcttgcca tgtacaccgt     1200

gactgtcatt gttggcttac tcattcacgc agtcatcgtc ttgccactcc tctacttctt     1260

ggtaacacgg aaaaaccctt gggtttttat tggagggttg ctgcaagcac tcatcaccgc     1320

tctggggacc tcttcaagtt ctgccaccct acccatcacc ttcaagtgcc tggaagagaa     1380

caatggcgtg gacaagcgcg tcaccagatt cgtgctcccc gtaggagcca ccattaacat     1440

ggatgggact gccctctatg aggctttggc tgccattttc attgctcaag ttaacaactt     1500

tgaactgaac ttcggacaaa ttattacaat cagcatcaca gccacagctg ccagtattgg     1560

ggcagctgga attcctcagg cgggcctggt cactatggtc attgtgctga catctgtcgg     1620

cctgcccact gacgacatca cgctcatcat cgcggtggac tggttcctgg atcgcctccg     1680

gaccaccacc aacgtactgg gagactccct gggagctggg attgtggagc acttgtcacg     1740

acatgaactg aagaacagag atgttgaaat gggtaactca gtgattgaag agaatgaaat     1800

gaagaaacca tatcaactga ttgcacagga caatgaaact gagaaaccca tcgacagtga     1860

aaccaagatg tag                                                        1873


<210> 61
<211> 497
<212> PRT
<213> Homo sapiens

<400> 61
Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30          


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45              


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60                  


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80  


Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95      


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110         


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125             


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140                 


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160 


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175     


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190         


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205             


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220                 


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240 


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255     


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270         


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285             


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300                 


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320 


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335     


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350         


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365             


Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380                 


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400 


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415     


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430         


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445             


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460                 


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480 


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495     


Gly 
    


<210> 62
<211> 1629
<212> DNA
<213> Homo sapiens

<400> 62
acccagaggg ggctttgacg tcagctcagc ttataagagg ctgctgggcc agggctgtgg       60

agacggagcc cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg      120

ccaagggctt ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt      180

ccccgcggtt cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg      240

cggcggtggc agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg      300

tggcctttga ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca      360

ccaagccctc ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc      420

accatctaga gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact      480

tcgtgcgcct cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg      540

tgtcagagga cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt      600

cagagctgga caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc      660

acccgggctt ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct      720

tccagtacag gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca      780

cctggaagga ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc      840

acctggaggc ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc      900

agctggagga cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg      960

ccggcctgct gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca     1020

cccagtatat ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg     1080

agctgctggg gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca     1140

ttggcctggc gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtact     1200

ggttcacggt ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg     1260

ggctgctgtc ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg     1320

ccttcgaccc tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct     1380

acttcgtgtc tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca     1440

tccagcgccc cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca     1500

gcccccaggc cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc     1560

atgcgctgag tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc     1620

tggtcctgc                                                             1629


<210> 63
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 63
Met Met Ser Phe Gly Gly Ala Asp Ala Leu Leu Gly Ala Pro Phe Ala 
1               5                   10                  15      


Pro Leu His Gly Gly Gly Ser Leu His Tyr Ala Leu Ala Arg Lys Gly 
            20                  25                  30          


Gly Ala Gly Gly Thr Arg Ser Ala Ala Gly Ser Ser Ser Gly Phe His 
        35                  40                  45              


Ser Trp Thr Arg Thr Ser Val Ser Ser Val Ser Ala Ser Pro Ser Arg 
    50                  55                  60                  


Phe Arg Gly Ala Gly Ala Ala Ser Ser Thr Asp Ser Leu Asp Thr Leu 
65                  70                  75                  80  


Ser Asn Gly Pro Glu Gly Cys Met Val Ala Val Ala Thr Ser Arg Ser 
                85                  90                  95      


Glu Lys Glu Gln Leu Gln Ala Leu Asn Asp Arg Phe Ala Gly Tyr Ile 
            100                 105                 110         


Asp Lys Val Arg Gln Leu Glu Ala His Asn Arg Ser Leu Glu Gly Glu 
        115                 120                 125             


Ala Ala Ala Leu Arg Gln Gln Gln Ala Gly Arg Ser Ala Met Gly Glu 
    130                 135                 140                 


Leu Tyr Glu Arg Glu Val Arg Glu Met Arg Gly Ala Val Leu Arg Leu 
145                 150                 155                 160 


Gly Ala Ala Arg Gly Gln Leu Arg Leu Glu Gln Glu His Leu Leu Glu 
                165                 170                 175     


Asp Ile Ala His Val Arg Gln Arg Leu Asp Asp Glu Ala Arg Gln Arg 
            180                 185                 190         


Glu Glu Ala Glu Ala Ala Ala Arg Ala Leu Ala Arg Phe Ala Gln Glu 
        195                 200                 205             


Ala Glu Ala Ala Arg Val Asp Leu Gln Lys Lys Ala Gln Ala Leu Gln 
    210                 215                 220                 


Glu Glu Cys Gly Tyr Leu Arg Arg His His Gln Glu Glu Val Gly Glu 
225                 230                 235                 240 


Leu Leu Gly Gln Ile Gln Gly Ser Gly Ala Ala Gln Ala Gln Met Gln 
                245                 250                 255     


Ala Glu Thr Arg Asp Ala Leu Lys Cys Asp Val Thr Ser Ala Leu Arg 
            260                 265                 270         


Glu Ile Arg Ala Gln Leu Glu Gly His Ala Val Gln Ser Thr Leu Gln 
        275                 280                 285             


Ser Glu Glu Trp Phe Arg Val Arg Leu Asp Arg Leu Ser Glu Ala Ala 
    290                 295                 300                 


Lys Val Asn Thr Asp Ala Met Arg Ser Ala Gln Glu Glu Ile Thr Glu 
305                 310                 315                 320 


Tyr Arg Arg Gln Leu Gln Ala Arg Thr Thr Glu Leu Glu Ala Leu Lys 
                325                 330                 335     


Ser Thr Lys Asp Ser Leu Glu Arg Gln Arg Ser Glu Leu Glu Asp Arg 
            340                 345                 350         


His Gln Ala Asp Ile Ala Ser Tyr Gln Glu Ala Ile Gln Gln Leu Asp 
        355                 360                 365             


Ala Glu Leu Arg Asn Thr Lys Trp Glu Met Ala Ala Gln Leu Arg Glu 
    370                 375                 380                 


Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala 
385                 390                 395                 400 


Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Ile Gly Phe Gly 
                405                 410                 415     


Pro Ile Pro Phe Ser Leu Pro Glu Gly Leu Pro Lys Ile Pro Ser Val 
            420                 425                 430         


Ser Thr His Ile Lys Val Lys Ser Glu Glu Lys Ile Lys Val Val Glu 
        435                 440                 445             


Lys Ser Glu Lys Glu Thr Val Ile Val Glu Glu Gln Thr Glu Glu Thr 
    450                 455                 460                 


Gln Val Thr Glu Glu Val Thr Glu Glu Glu Glu Lys Glu Ala Lys Glu 
465                 470                 475                 480 


Glu Glu Gly Lys Glu Glu Glu Gly Gly Glu Glu Glu Glu Ala Glu Gly 
                485                 490                 495     


Gly Glu Glu Glu Thr Lys Ser Pro Pro Ala Glu Glu Ala Ala Ser Pro 
            500                 505                 510         


Glu Lys Glu Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Ala 
        515                 520                 525             


Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala Glu Val 
    530                 535                 540                 


Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser 
545                 550                 555                 560 


Pro Pro Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala 
                565                 570                 575     


Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala 
            580                 585                 590         


Lys Ser Pro Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val 
        595                 600                 605             


Lys Glu Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Val Lys Glu 
    610                 615                 620                 


Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Glu Lys Ala Lys Ser 
625                 630                 635                 640 


Pro Thr Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Glu 
                645                 650                 655     


Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala 
            660                 665                 670         


Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala Glu Ala 
        675                 680                 685             


Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser 
    690                 695                 700                 


Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu 
705                 710                 715                 720 


Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Thr Pro Glu Lys Ala 
                725                 730                 735     


Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser 
            740                 745                 750         


Pro Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Thr 
        755                 760                 765             


Pro Ala Lys Glu Glu Ala Arg Ser Pro Ala Asp Lys Phe Pro Glu Lys 
    770                 775                 780                 


Ala Lys Ser Pro Val Lys Glu Glu Val Lys Ser Pro Glu Lys Ala Lys 
785                 790                 795                 800 


Ser Pro Leu Lys Glu Asp Ala Lys Ala Pro Glu Lys Glu Ile Pro Lys 
                805                 810                 815     


Lys Glu Glu Val Lys Ser Pro Val Lys Glu Glu Glu Lys Pro Gln Glu 
            820                 825                 830         


Val Lys Val Lys Glu Pro Pro Lys Lys Ala Glu Glu Glu Lys Ala Pro 
        835                 840                 845             


Ala Thr Pro Lys Thr Glu Glu Lys Lys Asp Ser Lys Lys Glu Glu Ala 
    850                 855                 860                 


Pro Lys Lys Glu Ala Pro Lys Pro Lys Val Glu Glu Lys Lys Glu Pro 
865                 870                 875                 880 


Ala Val Glu Lys Pro Lys Glu Ser Lys Val Glu Ala Lys Lys Glu Glu 
                885                 890                 895     


Ala Glu Asp Lys Lys Lys Val Pro Thr Pro Glu Lys Glu Ala Pro Ala 
            900                 905                 910         


Lys Val Glu Val Lys Glu Asp Ala Lys Pro Lys Glu Lys Thr Glu Val 
        915                 920                 925             


Ala Lys Lys Glu Pro Asp Asp Ala Lys Ala Lys Glu Pro Ser Lys Pro 
    930                 935                 940                 


Ala Glu Lys Lys Glu Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu 
945                 950                 955                 960 


Lys Ala Lys Lys Pro Glu Glu Lys Pro Lys Thr Glu Ala Lys Ala Lys 
                965                 970                 975     


Glu Asp Asp Lys Thr Leu Ser Lys Glu Pro Ser Lys Pro Lys Ala Glu 
            980                 985                 990         


Lys Ala Glu Lys Ser Ser Ser Thr  Asp Gln Lys Asp Ser  Lys Pro Pro 
        995                 1000                 1005             


Glu Lys  Ala Thr Glu Asp Lys  Ala Ala Lys Gly Lys  
    1010                 1015                 1020 


<210> 64
<211> 3721
<212> DNA
<213> Homo sapiens

<400> 64
aaaagggccg gcgccctggt gctgccgcag tgcctcccgc cccgtcccgg cctcgcgcac       60

ctgctcaggc catgatgagc ttcggcggcg cggacgcgct gctgggcgcc ccgttcgcgc      120

cgctgcatgg cggcggcagc ctccactacg cgctagcccg aaagggtggc gcaggcggga      180

cgcgctccgc cgctggctcc tccagcggct tccactcgtg gacacggacg tccgtgagct      240

ccgtgtccgc ctcgcccagc cgcttccgtg gcgcaggcgc cgcctcaagc accgactcgc      300

tggacacgct gagcaacggg ccggagggct gcatggtggc ggtggccacc tcacgcagtg      360

agaaggagca gctgcaggcg ctgaacgacc gcttcgccgg gtacatcgac aaggtgcggc      420

agctggaggc gcacaaccgc agcctggagg gcgaggctgc ggcgctgcgg cagcagcagg      480

cgggccgctc cgctatgggc gagctgtacg agcgcgaggt ccgcgagatg cgcggcgcgg      540

tgctgcgcct gggcgcggcg cgcggtcagc tacgcctgga gcaggagcac ctgctcgagg      600

acatcgcgca cgtgcgccag cgcctagacg acgaggcccg gcagcgagag gaggccgagg      660

cggcggcccg cgcgctggcg cgcttcgcgc aggaggccga ggcggcgcgc gtggacctgc      720

agaagaaggc gcaggcgctg caggaggagt gcggctacct gcggcgccac caccaggaag      780

aggtgggcga gctgctcggc cagatccagg gctccggcgc cgcgcaggcg cagatgcagg      840

ccgagacgcg cgacgccctg aagtgcgacg tgacgtcggc gctgcgcgag attcgcgcgc      900

agcttgaagg ccacgcggtg cagagcacgc tgcagtccga ggagtggttc cgagtgaggc      960

tggaccgact gtcggaggca gccaaggtga acacagacgc tatgcgctca gcgcaggagg     1020

agataactga gtaccggcgt cagctgcagg ccaggaccac agagctggag gcactgaaaa     1080

gcaccaagga ctcactggag aggcagcgct ctgagctgga ggaccgtcat caggccgaca     1140

ttgcctccta ccaggaagcc attcagcagc tggacgctga gctgaggaac accaagtggg     1200

agatggccgc ccagctgcga gaataccagg acctgctcaa tgtcaagatg gctctggata     1260

tagagatagc cgcttacaga aaactcctgg aaggtgaaga gtgtcggatt ggctttggcc     1320

caattccttt ctcgcttcca gaaggactcc ccaaaattcc ctctgtgtcc actcacataa     1380

aggtgaaaag cgaagagaag atcaaagtgg tggagaagtc tgagaaagaa actgtgattg     1440

tggaggaaca gacagaggag acccaagtga ctgaagaagt gactgaagaa gaggagaaag     1500

aggccaaaga ggaggagggc aaggaggaag aagggggtga agaagaggag gcagaagggg     1560

gagaagaaga aacaaagtct cccccagcag aagaggctgc atccccagag aaggaagcca     1620

agtcaccagt aaaggaagag gcaaagtcac cggctgaggc caagtcccca gagaaggagg     1680

aagcaaaatc cccagccgaa gtcaagtccc ctgagaaggc caagtctcca gcaaaggaag     1740

aggcaaagtc accgcctgag gccaagtccc cagagaagga ggaagcaaaa tctccagctg     1800

aggtcaagtc ccccgagaag gccaagtccc cagcaaagga agaggcaaag tcaccggctg     1860

aggccaagtc tccagagaag gccaagtccc cagtgaagga agaagcaaag tcaccggctg     1920

aggccaagtc cccagtgaag gaagaagcaa aatctccagc tgaggtcaag tccccggaaa     1980

aggccaagtc tccaacgaag gaggaagcaa agtcccctga gaaggccaag tccccagaga     2040

aggaagaggc caagtcccct gagaaggcca agtccccagt gaaggcagaa gcaaagtccc     2100

ctgagaaggc caagtcccca gtgaaggcag aagcaaagtc ccctgagaag gccaagtccc     2160

cagtgaagga agaagcaaag tcccctgaga aggccaagtc cccagtgaag gaagaagcaa     2220

agtcccctga gaaggccaag tccccagtga aggaagaagc aaagaccccc gagaaggcca     2280

agtccccagt gaaggaagaa gctaagtccc cagagaaggc caagtcccca gagaaggcca     2340

agactcttga tgtgaagtct ccagaagcca agactccagc gaaggaggaa gcaaggtccc     2400

ctgcagacaa attccctgaa aaggccaaaa gccctgtcaa ggaggaggtc aagtccccag     2460

agaaggcgaa atctcccctg aaggaggatg ccaaggcccc tgagaaggag atcccaaaaa     2520

aggaagaggt gaagtcccca gtgaaggagg aggagaagcc ccaggaggtg aaagtcaaag     2580

agcccccaaa gaaggcagag gaagagaaag cccctgccac accaaaaaca gaggagaaga     2640

aggacagcaa gaaagaggag gcacccaaga aggaggctcc aaagcccaag gtggaggaga     2700

agaaggaacc tgctgtcgaa aagcccaaag aatccaaagt tgaagccaag aaggaagagg     2760

ctgaagataa gaaaaaagtc cccaccccag agaaggaggc tcctgccaag gtggaggtga     2820

aggaagacgc taaacccaaa gaaaagacag aggtagccaa gaaggaacca gatgatgcca     2880

aggccaagga acccagcaaa ccagcagaga agaaggaggc agcaccggag aaaaaagaca     2940

ccaaggagga gaaggccaag aagcctgagg agaaacccaa gacagaggcc aaagccaagg     3000

aagatgacaa gaccctctca aaagagccta gcaagcctaa ggcagaaaag gctgaaaaat     3060

cctccagcac agaccaaaaa gacagcaagc ctccagagaa ggccacagaa gacaaggccg     3120

ccaaggggaa gtaaggcagg gagaaaggaa catccggaac agccaaagaa actcagaaga     3180

gtcccggagc tcaaggatca gagtaacaca attttcactt tttctgtctt tatgtaagaa     3240

gaaactgctt agatgacggg gcctccttct tcaaacagga atttctgtta gcaatatgtt     3300

agcaagagag ggcactccca ggcccctgcc cccaggccct ccccaggcga tggacaatta     3360

tgatagctta tgtagctgaa tgtgatacat gccgaatgcc acacgtaaac acttgactat     3420

aaaaactgcc cccctccttt ccaaataagt gcatttattg cctctatgtg caactgacag     3480

atgaccgcaa taatgaatga gcagttagaa atacattatg cttgagatgt cttaacctat     3540

tcccaaatgc cttctgtttt ccaaaggagt ggtcaagccc ttgcccagag ctctctattc     3600

tggaagagcg gtccaggtgg ggccggggac tggccactga attatgccag ggcgcacttt     3660

ccactggagt tcactttcaa ttgcttctgt gcaataaaac caagtgctta taaaatgaaa     3720

a                                                                     3721


<210> 65
<211> 559
<212> PRT
<213> Homo sapiens

<400> 65
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser 
1               5                   10                  15      


Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys 
            20                  25                  30          


Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe 
        35                  40                  45              


Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
    50                  55                  60                  


Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
65                  70                  75                  80  


Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                85                  90                  95      


Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
            100                 105                 110         


Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu 
        115                 120                 125             


Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
    130                 135                 140                 


Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala 
145                 150                 155                 160 


Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asn Ser Thr Leu 
                165                 170                 175     


Ser Lys Ile Pro Ala Leu Gln Gly Ser Thr Lys Ser Pro Arg Tyr Ser 
            180                 185                 190         


Ser Ala Cys Pro Ser Thr Thr Lys Arg Ala Thr Phe Ser Asp Ser Leu 
        195                 200                 205             


Leu Ile Gln Pro Thr Ser Ala Gly Ser Thr Asp Arg Leu Pro Tyr Ser 
    210                 215                 220                 


Lys Ser Gly Asn Lys Asp Gly Val Thr Lys Ser Pro Glu Lys Arg Ser 
225                 230                 235                 240 


Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg Arg Gly Val Ser 
                245                 250                 255     


Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser Ser Ile Ser Ser 
            260                 265                 270         


Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg Arg Ala Gly Lys 
        275                 280                 285             


Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr Ala Ile Thr Pro 
    290                 295                 300                 


Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly Thr Pro Gly Thr 
305                 310                 315                 320 


Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr Pro Lys Ser Ala 
                325                 330                 335     


Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile Arg Thr Pro Pro 
            340                 345                 350         


Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile Asn Gln Pro Leu 
        355                 360                 365             


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Asp Asn Ile 
    370                 375                 380                 


Lys Tyr Gln Pro Lys Gly Gly Gln Val Arg Ile Leu Asn Lys Lys Ile 
385                 390                 395                 400 


Asp Phe Ser Lys Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys 
                405                 410                 415     


His Ser Ala Gly Gly Gly Asn Val Gln Ile Val Thr Lys Lys Ile Asp 
            420                 425                 430         


Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Lys Asn Ile Arg His 
        435                 440                 445             


Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser Val Lys Leu Asp Phe 
    450                 455                 460                 


Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Ala His His 
465                 470                 475                 480 


Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser Gln Lys Leu Asn Phe 
                485                 490                 495     


Arg Glu His Ala Lys Ala Arg Val Asp His Gly Ala Glu Ile Ile Thr 
            500                 505                 510         


Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro Arg Arg Leu Ser Asn 
        515                 520                 525             


Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu Ser Pro Gln Leu Ala 
    530                 535                 540                 


Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala Lys Gln Gly Leu 
545                 550                 555                 


<210> 66
<211> 2286
<212> DNA
<213> Homo sapiens

<400> 66
ggcgctcggg ctgcgcgggc tctgggcagc agcagcagca gcagcagcat cctctcttcc       60

tttacttccc ttccgcttct ttctcttcct tctccttctt tttccccccc ctccccttct      120

tcccctaacc cttctacccc tctccttttt ctccggaggg cgctaagtcc gtgagcggtg      180

gcagtcgcga ccgcgggtgc atccagtttc tgcgcccaga ttttattgat ctaatccaaa      240

gtatcttata acttctggct ggaattaaga ttcttcagct tgtctctaac cgaggaagca      300

ttgattggga gctactcatt cagaaaatta aaagaaagaa gccagaaaat attatcaacc      360

ctttgagaac acgacacaac gaactttata ttttaccact tccttgaata gttgcaggag      420

aaataacaag gcattgaaga atggcagatg aacggaaaga cgaagcaaag gcacctcact      480

ggacctcagc accgctaaca gaggcatctg cacactcaca tccacctgag attaaggatc      540

aaggcggagc aggggaagga cttgtccgaa gcgccaatgg attcccatac agggaggatg      600

aagagggtgc ctttggagag catgggtcac agggcaccta ttcaaatacc aaagagaatg      660

ggatcaacgg agagctgacc tcagctgaca gagaaacagc agaggaggtg tctgcaagga      720

tagttcaagt agtcactgct gaggctgtag cagtcctgaa aggtgaacaa gagaaagaag      780

ctcaacataa agaccagact gcagctctgc ctttagcagc tgaagaaaca gctaatctgc      840

ctccttctcc acccccatca cctgcctcag aacagactgt cacagtggag gaagcagcag      900

gtggggaatc agctctggct cccagtgtat ttaaacaggc aaaggacaaa gtctctaatt      960

ctaccttgtc aaagattcct gctttacagg gtagcacaaa gtccccaaga tacagctcag     1020

cctgccctag cacgactaaa agggctacat tttctgacag tttattaata cagcccacct     1080

cagcaggctc cacagaccgt ttgccatact caaaatcagg gaacaaggac ggagtaacca     1140

agagcccaga aaagcgctct tctctcccaa gaccttcctc cattctccct cctcggcgag     1200

gtgtgtcagg agacagagat gagaattcct tctctctcaa cagttctatc tcttcttcag     1260

cacggcggac caccaggtca gagccaattc gcagagcagg gaagagtggt acctcaacac     1320

ccactacccc tgggtctact gccatcactc ctggcacccc accaagttat tcttcacgca     1380

caccaggcac tcctggaacc cctagctatc ccaggacccc tcacacacca ggaaccccca     1440

agtctgccat cttggtgccg agtgagaaga aggtcgccat catacgtact cctccaaaat     1500

ctcctgcgac tcccaagcag cttcggctta ttaaccaacc actgccagac ctgaagaatg     1560

tcaaatccaa aatcggatca acagacaaca tcaaatacca gcctaaaggg gggcaggtta     1620

ggattttaaa caagaagatc gattttagca aagttcagtc cagatgtggt tccaaggata     1680

acatcaaaca ttcggctggg ggcggaaatg tacaaattgt taccaagaaa atagacctaa     1740

gccatgtgac atccaaatgt ggctctctga agaacatccg ccacaggcca ggtggcggac     1800

gtgtgaaaat tgagagtgta aaactagatt tcaaagaaaa ggcccaagct aaagttggtt     1860

ctcttgataa tgctcatcat gtacctggag gtggtaatgt caagattgac agccaaaagt     1920

tgaacttcag agagcatgct aaagcccgtg tggaccatgg ggctgagatc attacacagt     1980

ccccaggcag atccagcgtg gcatcacccc gacgactcag caatgtctcc tcgtctggaa     2040

gcatcaacct gctcgaatct cctcagcttg ccactttggc tgaggatgtc actgctgcac     2100

tcgctaagca gggcttgtga atatttctca tttagcattg aaataataat atttaggcat     2160

gagctcttgg caggagtggg ctctgagcag ttgttatatt cattctttat aaaccataaa     2220

ataaataatc tcatccccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2280

aaaaaa                                                                2286


<210> 67
<211> 360
<212> PRT
<213> Homo sapiens

<400> 67
Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15      


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30          


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45              


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60                  


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80  


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95      


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110         


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125             


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140                 


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160 


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175     


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190         


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205             


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220                 


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240 


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255     


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270         


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285             


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300                 


Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser 
305                 310                 315                 320 


Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly 
                325                 330                 335     


Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp 
            340                 345                 350         


Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360 


<210> 68
<211> 9135
<212> DNA
<213> Homo sapiens

<400> 68
ctggcaggaa tttcttgctt ggagctcaga caacaaaggc atagagagat tggttttctt       60

tctctcagca tctccaccca accagcagaa aaccggtctc tgaggttcca ccaaaatatg      120

gaacttgatt ttggacactt tgacgaaaga gataagacat ccaggaacat gcgaggctcc      180

cggatgaatg ggttgcctag ccccactcac agcgcccact gtagcttcta ccgaaccaga      240

accttgcagg cactgagtaa tgagaagaaa gccaagaagg tacgtttcta ccgcaatggg      300

gaccgctact tcaaggggat tgtgtacgct gtgtcctctg accgttttcg cagctttgac      360

gccttgctgg ctgacctgac gcgatctctg tctgacaaca tcaacctgcc tcagggagtg      420

cgttacattt acaccattga tggatccagg aagatcggaa gcatggatga actggaggaa      480

ggggaaagct atgtctgttc ctcagacaac ttctttaaaa aggtggagta caccaagaat      540

gtcaatccca actggtctgt caacgtaaaa acatctgcca atatgaaagc cccccagtcc      600

ttggctagca gcaacagtgc acaggccagg gagaacaagg actttgtgcg ccccaagctg      660

gttaccatca tccgcagtgg ggtgaagcct cggaaggctg tgcgtgtgct tctgaacaag      720

aagacagccc actcttttga gcaagtcctc actgatatca cagaagccat caaactggag      780

accggggttg tcaaaaaact ctacactctg gatggaaaac aggtaacttg tctccatgat      840

ttctttggtg atgatgatgt gtttattgcc tgtggtcctg aaaaatttcg ctatgctcag      900

gatgattttt ctctggatga aaatgaatgc cgagtcatga agggaaaccc atcagccaca      960

gctggcccaa aggcatcccc aacacctcag aagacttcag ccaagagccc tggtcctatg     1020

cgccgaagca agtctccagc tgactcagca aacggaacct ccagcagcca gctctctacc     1080

cccaagtcta agcagtctcc catctctacg cccaccagtc ctggcagcct ccggaagcac     1140

aaggacctgt acctgcctct gtccttggat gactcggact cgcttggtga ttccatgtaa     1200

aggaggggag agtgctcaga gtccagagta caaatccaag cctatcattg tagtagggta     1260

cttctgctca agtgtccaac agggctattg gtgctttcaa gtttttattt tgttgttgtt     1320

gttattttga aaaacacatt gtaatatgtt gggtttattt tcctgtgatt tctcctctgg     1380

gccactgatc cacagttacc aattatgaga gatagattga taaccatcct ttggggcagc     1440

attccaggga tgcaaaatgt gctagtccat gacctttcaa tggaaagctt aggtgcctgc     1500

gttatatttg ccctgtctaa ttttgcccat acagtcttcc ttctgtagag ggctgtttac     1560

atatacagca cttaaaatgt ttgtgtggga aaaaaaaaac tcattggcag atccaagaat     1620

gacaaacaca agtgcccctt ttctctggat ctcaagaatg gtggaggacc ctggaaggac     1680

agcaaggcag ctccccagcc tcactcttca ctcctgattg aggcccgggt ttgttgtcca     1740

gcaccaattc tggctgtcaa tggggagaaa taaaccaaca acttataatt gtgacaccag     1800

atgcttagga tcctggtgct gggttagcta agagaataga cagaattgga aaatactgca     1860

gacatttccg aagagtttat aaagcacagt gaattcctgg tcaatctctc cactgaggca     1920

atttggaatc aataagcaat tgataatagt ttggagtaag ggacttcata tacctgattc     1980

ctctagaagg ctgtctaaca taccacatga ttacatgaac tgtatggtat ccatctatct     2040

ctgttctatt gaatgccttg ttaacagcca acactgaaaa cactgtgaga atttgttttc     2100

aggtctgaca cctttcagtc tctttttata gcaagaaatc aatatccttt ttataaaaat     2160

tcatgtctgt atttcaggag caaactcttc aggctccttt tttataaact ggtgattttt     2220

cttttgtcta aaaaacacat gaagaaaatt taccaaaaaa aaaaaaaaaa gcagaagaat     2280

aatgtagttt agaaattatg ctgtcactgc caaacagtaa cctccaggag aaaacaagat     2340

gaatagcaga ggccaattca atagaatcag ttttttgata gctttttaac agttatgctt     2400

gcattaataa tttcaatgtg gaccagacat tctaattata ttttaaatga aatgttacag     2460

catattttaa gcaactcttt ttatctataa tcctaatatt tcatactgaa gacacagaaa     2520

tctttcactt gtctttaaca ttagaaagga tttctcttta ctaaggactg atcatttgaa     2580

atagttttca gtcttttgag atacaggttt ataacactgc tttttttttt ctgtaatcat     2640

agcccataat ggcaaagaca actaaattta agtgaaggtc atgcatgcca attctgtgtt     2700

tgcttttagc agatatgaag atttccttat ttctttgtaa ttgtgcagat attttgaaag     2760

gcacagcatt cgaagccaag ctgctgtttg gctactgaat ggcttgcagt tgttcctcca     2820

ctctaaatgg aatgagcttg ctgtgtgtgt gtgtggtggt ggtgggaggg ggtggtgcat     2880

gtgtgtgtgt gtgtgtgcat ctgcagctgc ttcaaaatta ggaaatacta caggacaccc     2940

ctgtaatgga ttggtggcaa ctgggtggca ctgctgatgt gcactgtgta ggggggaacc     3000

cagtggtggt ggggtagctc agatgcccct agacaagctt cagatgtctg tagctaccag     3060

aaacattttc ggttcaggaa aagtgagatg atggtagtac tggtttctgg tgaaattgaa     3120

gaaccccaaa tgatgaggat ctctttttgc cccctctcct ttttttgtag acccattcaa     3180

aaccattaat aagcccattt tactaagccc ctatttcttt ctagaagctc agggttttct     3240

tagtgcctcc cagaacattt tgtagttaat tgggaaaaag tgatacttgg attagggggt     3300

gtgggcataa agaatggtgg gaggcctgat tttaaacttc aggccagaac ccccaatgac     3360

tccacccata gtctcacttt aggtctcatt tagtccatca cctttatttt aagttgagga     3420

agtggaggct ggtaaagagc aggaccagag gaagaatcca gatttcctta tgcttgggcc     3480

tcacactagc tctctgagta tttccttgat tgcggtatat gtactactag aaaataccaa     3540

atggatatat tttctttagg ataacctttg aaccaacaat cttcaataac aatagtacat     3600

cttccatctt acttttaatc gagtataagg aaatgtttct ttatggccat tttggaggga     3660

gcaggggatg aggcttggca tagtccaaaa tttaagtctc caataattaa ttgcatttta     3720

aattggccca ctttcaaggc aatttttttt gtgtgtctgt aactgagctc ctccacccct     3780

gtcattcact tccaatttta cccaatccaa ttttagcact caagttccat tgtgttaatt     3840

tctgcacggt caacaaacat caagtcagca agcatttgcc accactccct atacttctcc     3900

ctccttctta cacacacaca cacacacaca cacacaatcc atctcttgct tgttcctacc     3960

tcctgatttt tcttccctac agaaatagaa atagggacaa agaaggggaa aatgtatata     4020

ttggggctgg gctgaacaac taacttcata agtagtatta actaggggta aattgagaga     4080

aaagctcctt ttctcttcac tgttttggaa aggatagcca ttagcatgac tgctttgtgt     4140

ccttatggac tttagtatta gcctagattg aattatagcg ttttctagct ggaaggaacc     4200

ttaagatcac atcatctact cctctactcc aaatttctca ttcttcaggc caggaaaccg     4260

agacacagag gtaaagtaat ttccccaagg tcacacagct ggctggggca ggattgggtt     4320

tacaacccac atctcctggc tcttattcca gggccttttc ccactaagta gtattgcctt     4380

ccattaggct cctgagagtt atttctcagg gtcatgttgc atcttggagc cacatgctgc     4440

tgccctgatc tcagtgggaa atccacccag caacctaata cagccccttt tccctgcatt     4500

cacctggttc ccatccacat gggttgcaga tgtccttgaa gagagtgagg cattgagggc     4560

caataggagc aatggggtcc ctggccttgt ccatctgatt caggagatca ctgctccatc     4620

gtgaggagcc ctctgaatag ccccccactg aatgcttgcc ttgcccaaat ggaatggagg     4680

aagattgatt ttctccatca gttcaccttg tgtcatctca taatggttgg tctttccagg     4740

ctgagggaaa tgtttcttgt ttccagagta gaaaaagaaa gagtggaaca atagctttgt     4800

tcatcctaac tttctgagat ggcttttcaa cattttaaaa aaactagtgt ggctaccatt     4860

cactggcaat gatttctttt agaatatggg agtaagatga gctagagaaa ataacctggt     4920

ctcactgtgg ttgccctcat ccacaatgtc cccaaagcca tcctgctctg atgaggacaa     4980

tttccaggta taagcaaggg gctttgtgac aaaaatgtac cctggctgat gttaaacatt     5040

ggctcctgtg tttgcaccaa aatagcaagc tgtgtgctct atacactctt cccatcgtct     5100

tgtgtacact gctcctgtgg ccttccacag cagaaaccag ggcaaaaggg tccaaacaca     5160

tggttttcct tgctgcaagg ctcttcctgg gaactaaggg ggtatttatt agttcagttc     5220

taagagacct ccttctgggc ttaccccact cctcaggtac ttctctctcc ttcctccttc     5280

tcctccacag tcacaagtaa ccaaggaacc tgaaagtgga tgtgtagcta tttgaagaag     5340

gcaaggaacc ctgagattct tctttgaatc ctctagtcca agtcttagac cagtgattgg     5400

tgcttacctt gaacaaaatt ttgtctgtgt tcctaatccc ttcaatactc tgggtacaat     5460

gctcccaatc accctgcaca tttgattcta aatggctttt attttttaaa aatccatatc     5520

cctaggacaa gagaacagga tgcctatatc cccaaaatga gctccaggac actgatggga     5580

atgatcccaa agatcacccc acctcagaaa cgtctgtgcc aagagacttc cccagataga     5640

aacactggga cagtggtttg aacgacttct tttatggttg tccagtttgc tatggaaata     5700

aaaggcattg attttttaaa aagatgattg gaacctgtct ttggccacat agggccactt     5760

ggatccattt ccaggcctta ctcatatatt gccttcactg aagggctttg gctttaagtc     5820

ccagactggt ctcccaagtg aaccataagt gttttggagc tcatctgggg tgaggcatga     5880

gaatgttgcc ccatctatcc cttcaggaaa aggtgccttc cctccctttc tcctaaagcc     5940

tggtccccag aaattgtttt tgtctccaaa agtctagtat ggtctttata cacccagact     6000

cttagtgttg cgtcctgcct tgtttccttg ttaaggatct atgcagacct cccgctttgg     6060

cttagctagc gtgacattgg ctatcatttg acaagactaa cttttttttt tttttttttt     6120

tgactgagtc tccctctgtc acctaggctg gagtgcagtg gcacaatctt ggctcgctgc     6180

aaccttcacc cttcacctcc caggtcgaag cgattctcct gcctcagtct cccgagtagc     6240

tgggattaca ggcgtgcgcc accaaatctg gctatttttt tattattatt atttttagta     6300

gagatggggt ttcaccatgt tggccagact ggtcttgaac tcttggcctc aaattatctg     6360

cccacctcgg cctcccaaag tgctgggatt acaggcatga gccaccatgc ccagctgaca     6420

agactaattt tttatccctt ggtttattgg cttcaacatc ttctggaatc agaggtgatt     6480

ttttcttacc ttggatgcct gagactaggg gagtatagaa ttccaattgg taattaaggc     6540

atctttctgc tcctgatcag aagggcaggt tagttgggag aggtcagatg gcacaacaga     6600

agtcaccttg taagtaaggc aaagacttga aggcattagc gtttctcatt actaggtcaa     6660

taacctgagg gaatcaatgg ctttttgccg ctctacctct tgtgtatctc tttgactttt     6720

ctttctctgt ctagtttcct ctgttctcag tttatattct atgttatcag tctctctttc     6780

cacagtacaa acatccatcc tttctcctgt gcaattctgt ctctccctct tattatcttt     6840

atttgtactt tttccttcct ccctgtctag gcattgggca tgtgcctctt cttagcctgt     6900

gattttgcct tgggactgat gataaattat ttccagattc aatcagccct ggtcctaccc     6960

cagtccaatc agaagtatgt tggtgggaat caacctgatc ctggcccttt cttcttctcc     7020

attttcattc gtaatccccc tcagcagatc tttacaagca gtttccttat agctcatgta     7080

tctttaggtc tttgccttcc aagcactgta cagaatactt tgtggttcct ttttagtctg     7140

acattttgtg gagcagtgaa gcgtgctcag agacataatc agctgaagag aaaaaatcca     7200

cccatggatt tatatcagct aaatactaat aattgatttt gtttgatgtg cccataattt     7260

ttaaagctgc aatataatat aatgagggac cacaggtaat ttctcctgtc atttgttttg     7320

gctggatggg ggtgggggag taattgctta aagttttacc attacacatt aaactctcta     7380

taataatctt gtttggggct tgctaactgt tgagctgttt taactaaact ggtaggcaat     7440

cggagttgat ttaaatgaaa agataattta acaaatctat actataaaaa gagacatttg     7500

cttaattgac atgtattttt tccttctgag tcacctaaac atttactctt gacaccaact     7560

gttcatgata ctgaatagac agtccatata agagaaatta gtggacctaa agaagccaga     7620

ttgtaggtgt taatttatta aacagagtgc aaagcccttg gaaatgtcac tgcttggcaa     7680

taccatatgg aatgccaaaa tttacaatga cttttcttta taagttatcc aaaagggatt     7740

tgaacaagta agaggttatg ccaaaatgtc tccaatgtat ggtcctgtaa tatattgcag     7800

cttgaagcca atgatccctt atgacttgta tacaactaat gcatgtttta ttgaattttg     7860

catttcccac gtgtggtaag ttctttaaaa tgtttttgat cacctttttg tgccattaaa     7920

cttgtacaga aaatgttttt atggccattt tcaaagggag aaagtttaaa atggaaacag     7980

cccacccttt ctgccctata gctgtagtta gaattgagta cctgtagcaa aacagctgta     8040

attggtggtt gtagtgttag aggtgttagc ttgctagtga ctagctttgg agagtaaatg     8100

catggtattg tacatcacat ttcttaactc gttttaacct ctgaaaagaa tatattcttc     8160

tttgtagtcc ttcttcccac ccccttgccc tctccctctc cctgctccca gttgtcttac     8220

agttgtaaat atctgatttg aggcccaata actcttgcca agtaaagtca gcaaacaaca     8280

aacaaaccaa aatgtgggga aaaggcattt ctcaaccatc tctcagcagt tattgatcat     8340

ttcttaagga acagcattgt gatcaaagac tcaactttac gtaaaaatca gtggtaaatt     8400

ggggttgtat ttggccattt gattacattt caggattgaa tagttttcag aatcacatgt     8460

aatccaaaga cagtaggtag tgatgtccct tatccctgca gctgttttaa gatagagacc     8520

tcagaagact ctgcttgacc gatgaccaat aattatttga aaaaaaaaga aaaaatgaga     8580

gaaataaaac agatatttaa gaactttagc cacctattta gaatagttat agccagaaaa     8640

aaaaacaagg gcatgagttc aaatgcatta ctatcagtgt cctaggcaat acctaaccta     8700

ctctgaaatt gtgattcaaa agcagtattt caagaggcat tctccttttt tggtttgctg     8760

accccacttg gactggtagg tttggtgagg cccccataaa ccagctggag cagacccttt     8820

tcatctcctg tgcctgtaac acccctcttc ccccaccccc tccgcaattc aatgagggct     8880

ttcttgggtc agaggacttc aaggttgtct agagaagttt gccatgtgtg taaggtgctg     8940

tgaactgtga gtgctgaaga ttcgcagcat tcaataccag gcagccaaag agctgctctt     9000

gcaattattt tggctctcaa gctctgttct tcatcgcatt ctcatttctg tgtacatttg     9060

caagatgtgt gtaatgtcat tttccaaaaa taaaatttga tttcaataaa aaaaaaaaaa     9120

aaaaaaaaaa aaaaa                                                      9135


<210> 69
<211> 456
<212> PRT
<213> Homo sapiens

<400> 69
Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210> 70
<211> 3440
<212> DNA
<213> Homo sapiens

<400> 70
agcggagcgg gcgagcaagg gagcgagcag gacaggagcc tgatcccaca gctgctgctc       60

cagcccgcga tgaggaaaag tccaggtctg tctgactgtc tttgggcctg gatcctcctt      120

ctgagcacac tgactggaag aagctatgga cagccgtcat tacaagatga acttaaagac      180

aataccactg tcttcaccag gattttggac agactcctag atggttatga caatcgcctg      240

agaccaggat tgggagagcg tgtaaccgaa gtgaagactg atatcttcgt caccagtttc      300

ggacccgttt cagaccatga tatggaatat acaatagatg tatttttccg tcaaagctgg      360

aaggatgaaa ggttaaaatt taaaggacct atgacagtcc tccggttaaa taacctaatg      420

gcaagtaaaa tctggactcc ggacacattt ttccacaatg gaaagaagtc agtggcccac      480

aacatgacca tgcccaacaa actcctgcgg atcacagagg atggcacctt gctgtacacc      540

atgaggctga cagtgagagc tgaatgtccg atgcatttgg aggacttccc tatggatgcc      600

catgcttgcc cactaaaatt tggaagttat gcttatacaa gagcagaagt tgtttatgaa      660

tggaccagag agccagcacg ctcagtggtt gtagcagaag atggatcacg tctaaaccag      720

tatgaccttc ttggacaaac agtagactct ggaattgtcc agtcaagtac aggagaatat      780

gttgttatga ccactcattt ccacttgaag agaaagattg gctactttgt tattcaaaca      840

tacctgccat gcataatgac agtgattctc tcacaagtct ccttctggct caacagagag      900

tctgtaccag caagaactgt ctttggagta acaactgtgc tcaccatgac aacattgagc      960

atcagtgcca gaaactccct ccctaaggtg gcttatgcaa cagctatgga ttggtttatt     1020

gccgtgtgct atgcctttgt gttctcagct ctgattgagt ttgccacagt aaactatttc     1080

actaagagag gttatgcatg ggatggcaaa agtgtggttc cagaaaagcc aaagaaagta     1140

aaggatcctc ttattaagaa aaacaacact tacgctccaa cagcaaccag ctacacccct     1200

aatttggcca ggggcgaccc gggcttagcc accattgcta aaagtgcaac catagaacct     1260

aaagaggtca agcccgaaac aaaaccacca gaacccaaga aaacctttaa cagtgtcagc     1320

aaaattgacc gactgtcaag aatagccttc ccgctgctat ttggaatctt taacttagtc     1380

tactgggcta cgtatttaaa cagagagcct cagctaaaag cccccacacc acatcaatag     1440

atcttttact cacattctgt tgttcagtcc tctgcactgg gaatttattt atgttctcaa     1500

cgcagtaatt cccatctgct ttattgcctc tgtcttaaag aatttgaaag tttccttatt     1560

ttcataattc atttaagaac aagagacccc tgtctggcag tctggagcaa agcagactat     1620

gcagcttgga gacaggattc tgacagagca agcgaaagag caaagtcatg tcagaaggag     1680

acagaatgag agagaaaaga gggggaagat ggttcaaaga tacaagaaaa agtagaaaaa     1740

aaaataacac ttaactaaaa cccctaggtc atttgtagat atatatttcc aaatattcta     1800

aaaaagatac tgtatatgtc aaaaatattt ttatgtgaag gtgtttcaaa gggtaaatta     1860

taaatgtttc atgaagaaaa aattttaaaa atctacgtct ttattacaca aactatggtg     1920

tgcttatgtt tttgttttgc tttttaaact gatgtatagc tttaacattt tgtttccaaa     1980

gctgaagatc cccattcttt ctctttgaaa aaaaaaaagg cctaatgcat tattttgtca     2040

taaaatgcta ttttaaaatt catggaactt tcatacgtaa aggtgcagtt gctcattgta     2100

gagcacattt agtccaatga agataaatgc tttaaatagt ttacttcact ttcatctgag     2160

cttttaccac tagactcaag gaagaataat tttaacagac atgtatactc catagaaact     2220

aaattaaaat agtttaaaaa tattcccttt ttcaccctat tttcagatag cacatgagcc     2280

caacactcac ttaattctca ttatgaagat gtttttagag gggcaaaaat attttgcaag     2340

ctctggaatt gttgaatgta ttcttttata taactacatt aaaagcttta gattgaaatt     2400

tatgactagc aaacaaaaat agaatatata aacgatatat gtaaatatac agcatgagat     2460

tgtacatttt ttactttttt aaaattgtgt tcttaaaata ttgtgtaaga atcactgcac     2520

ttagctgttg gaatgttgtt aaatgctatg gaaatacatt tagaacctgc atttaagaac     2580

agaacagcaa gtatgaacca catggaactt aaaacatatg ggtgtgaagt ccacttatgt     2640

agacaaaact tataatttcc aaactgttgt ctagtataca gtgatcagtt gctctctgtt     2700

caagtcattc cacacatttc cctattttag gctattataa tatagaaaga aaatgggaag     2760

cattagttgg agctagaaaa tgaactgtat attattgcta tatttgctaa taccaactat     2820

ttcaataagt gttgtaccat atgtagcatt aaatataaaa tacataaaag aatgtacaga     2880

aaatagcttt tattgagtaa tattacattt catttatact gtagcaatat atttgtaggt     2940

atactatgta agggctttaa ataaaagagg tccattaata cttccttata aaaattctag     3000

tctgtttcat tactgcccag atgttttaga gataaatatt tatgcagaag gtatttttga     3060

agtctccttt tgtctgatag agtttaacag atatttaaat ttagtgctca gaatccacaa     3120

gtcacggtct aaacacactt agaatactac agcataaatc tgttagcatt attgccaaat     3180

aagacagttg ggatccaaac ccaagtcttg agcaatgttt ttctcaaaaa gctgctatcc     3240

aatgatatag gaaaatacat tgtgttttcc taaacacact tttcttttta aatgtgcttc     3300

attgtttgat ttggtcctgc ctaaatttca caagctaggc caatgaaggc tgaatcaaag     3360

acatttcatc caccaatatc atgtgtagat attatgtata gaaaataaaa taaattatgg     3420

ctccaaaaaa aaaaaaaaaa                                                 3440


