                         SEQUENCE LISTING

<110>  AUTOTELIC LLC
       TRIEU, Vuong
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCER

<130>  074271-000014WO00

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta2 antisense 
       oligonucleotide

<400>  1
cggcatgtct attttgta                                                     18


<210>  2
<211>  5882
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens transforming growth factor beta 2 (TGFB2), 
       transcript variant 2

<400>  2
gtgatgttat ctgctggcag cagaaggttc gctccgagcg gagctccaga agctcctgac       60

aagagaaaga cagattgaga tagagataga aagagaaaga gagaaagaga cagcagagcg      120

agagcgcaag tgaaagaggc aggggagggg gatggagaat attagcctga cggtctaggg      180

agtcatccag gaacaaactg aggggctgcc cggctgcaga caggaggaga cagagaggat      240

ctattttagg gtggcaagtg cctacctacc ctaagcgagc aattccacgt tggggagaag      300

ccagcagagg ttgggaaagg gtgggagtcc aagggagccc ctgcgcaacc ccctcaggaa      360

taaaactccc cagccagggt gtcgcaaggg ctgccgttgt gatccgcagg gggtgaacgc      420

aaccgcgacg gctgatcgtc tgtggctggg ttggcgtttg gagcaagaga aggaggagca      480

ggagaaggag ggagctggag gctggaagcg tttgcaagcg gcggcggcag caacgtggag      540

taaccaagcg ggtcagcgcg cgcccgccag ggtgtaggcc acggagcgca gctcccagag      600

caggatccgc gccgcctcag cagcctctgc ggcccctgcg gcacccgacc gagtaccgag      660

cgccctgcga agcgcaccct cctccccgcg gtgcgctggg ctcgccccca gcgcgcgcac      720

acgcacacac acacacacac acacacacgc acgcacacac gtgtgcgctt ctctgctccg      780

gagctgctgc tgctcctgct ctcagcgccg cagtggaagg caggaccgaa ccgctccttc      840

tttaaatata taaatttcag cccaggtcag cctcggcggc ccccctcacc gcgctcccgg      900

cgcccctccc gtcagttcgc cagctgccag ccccgggacc ttttcatctc ttcccttttg      960

gccggaggag ccgagttcag atccgccact ccgcacccga gactgacaca ctgaactcca     1020

cttcctcctc ttaaatttat ttctacttaa tagccactcg tctctttttt tccccatctc     1080

attgctccaa gaattttttt cttcttactc gccaaagtca gggttccctc tgcccgtccc     1140

gtattaatat ttccactttt ggaactactg gccttttctt tttaaaggaa ttcaagcagg     1200

atacgttttt ctgttgggca ttgactagat tgtttgcaaa agtttcgcat caaaaacaac     1260

aacaacaaaa aaccaaacaa ctctccttga tctatacttt gagaattgtt gatttctttt     1320

ttttattctg acttttaaaa acaacttttt tttccacttt tttaaaaaat gcactactgt     1380

gtgctgagcg cttttctgat cctgcatctg gtcacggtcg cgctcagcct gtctacctgc     1440

agcacactcg atatggacca gttcatgcgc aagaggatcg aggcgatccg cgggcagatc     1500

ctgagcaagc tgaagctcac cagtccccca gaagactatc ctgagcccga ggaagtcccc     1560

ccggaggtga tttccatcta caacagcacc agggacttgc tccaggagaa ggcgagccgg     1620

agggcggccg cctgcgagcg cgagaggagc gacgaagagt actacgccaa ggaggtttac     1680

aaaatagaca tgccgccctt cttcccctcc gaaaatgcca tcccgcccac tttctacaga     1740

ccctacttca gaattgttcg atttgacgtc tcagcaatgg agaagaatgc ttccaatttg     1800

gtgaaagcag agttcagagt ctttcgtttg cagaacccaa aagccagagt gcctgaacaa     1860

cggattgagc tatatcagat tctcaagtcc aaagatttaa catctccaac ccagcgctac     1920

atcgacagca aagttgtgaa aacaagagca gaaggcgaat ggctctcctt cgatgtaact     1980

gatgctgttc atgaatggct tcaccataaa gacaggaacc tgggatttaa aataagctta     2040

cactgtccct gctgcacttt tgtaccatct aataattaca tcatcccaaa taaaagtgaa     2100

gaactagaag caagatttgc aggtattgat ggcacctcca catataccag tggtgatcag     2160

aaaactataa agtccactag gaaaaaaaac agtgggaaga ccccacatct cctgctaatg     2220

ttattgccct cctacagact tgagtcacaa cagaccaacc ggcggaagaa gcgtgctttg     2280

gatgcggcct attgctttag aaatgtgcag gataattgct gcctacgtcc actttacatt     2340

gatttcaaga gggatctagg gtggaaatgg atacacgaac ccaaagggta caatgccaac     2400

ttctgtgctg gagcatgccc gtatttatgg agttcagaca ctcagcacag cagggtcctg     2460

agcttatata ataccataaa tccagaagca tctgcttctc cttgctgcgt gtcccaagat     2520

ttagaacctc taaccattct ctactacatt ggcaaaacac ccaagattga acagctttct     2580

aatatgattg taaagtcttg caaatgcagc taaaattctt ggaaaagtgg caagaccaaa     2640

atgacaatga tgatgataat gatgatgacg acgacaacga tgatgcttgt aacaagaaaa     2700

cataagagag ccttggttca tcagtgttaa aaaatttttg aaaaggcggt actagttcag     2760

acactttgga agtttgtgtt ctgtttgtta aaactggcat ctgacacaaa aaaagttgaa     2820

ggccttattc tacatttcac ctactttgta agtgagagag acaagaagca aatttttttt     2880

aaagaaaaaa ataaacactg gaagaattta ttagtgttaa ttatgtgaac aacgacaaca     2940

acaacaacaa caacaaacag gaaaatccca ttaagtggag ttgctgtacg taccgttcct     3000

atcccgcgcc tcacttgatt tttctgtatt gctatgcaat aggcaccctt cccattctta     3060

ctcttagagt taacagtgag ttatttattg tgtgttacta tataatgaac gtttcattgc     3120

ccttggaaaa taaaacaggt gtataaagtg gagaccaaat actttgccag aaactcatgg     3180

atggcttaag gaacttgaac tcaaacgagc cagaaaaaaa gaggtcatat taatgggatg     3240

aaaacccaag tgagttatta tatgaccgag aaagtctgca ttaagataaa gaccctgaaa     3300

acacatgtta tgtatcagct gcctaaggaa gcttcttgta aggtccaaaa actaaaaaga     3360

ctgttaataa aagaaacttt cagtcagaat aagtctgtaa gttttttttt ttctttttaa     3420

ttgtaaatgg ttctttgtca gtttagtaaa ccagtgaaat gttgaaatgt tttgacatgt     3480

actggtcaaa cttcagacct taaaatattg ctgtatagct atgctatagg ttttttcctt     3540

tgttttggta tatgtaacca tacctatatt attaaaatag atggatatag aagccagcat     3600

aattgaaaac acatctgcag atctcttttg caaactatta aatcaaaaca ttaactactt     3660

tatgtgtaat gtgtaaattt ttaccatatt ttttatattc tgtaataatg tcaactatga     3720

tttagattga cttaaatttg ggctcttttt aatgatcact cacaaatgta tgtttctttt     3780

agctggccag tacttttgag taaagcccct atagtttgac ttgcactaca aatgcatttt     3840

ttttttaata acatttgccc tacttgtgct ttgtgtttct ttcattatta tgacataagc     3900

tacctgggtc cacttgtctt ttcttttttt tgtttcacag aaaagatggg ttcgagttca     3960

gtggtcttca tcttccaagc atcattacta accaagtcag acgttaacaa atttttatgt     4020

taggaaaagg aggaatgtta tagatacata gaaaattgaa gtaaaatgtt ttcattttag     4080

caaggattta gggttctaac taaaactcag aatctttatt gagttaagaa aagtttctct     4140

accttggttt aatcaatatt tttgtaaaat cctattgtta ttacaaagag gacacttcat     4200

aggaaacatc tttttcttta gtcaggtttt taatattcag ggggaaattg aaagatatat     4260

attttagtcg atttttcaaa aggggaaaaa agtccaggtc agcataagtc attttgtgta     4320

tttcactgaa gttataaggt ttttataaat gttctttgaa ggggaaaagg cacaagccaa     4380

tttttcctat gatcaaaaaa ttctttcttt cctctgagtg agagttatct atatctgagg     4440

ctaaagttta ccttgcttta ataaataatt tgccacatca ttgcagaaga ggtatcctca     4500

tgctggggtt aatagaatat gtcagtttat cacttgtcgc ttatttagct ttaaaataaa     4560

aattaatagg caaagcaatg gaatatttgc agtttcacct aaagagcagc ataaggaggc     4620

gggaatccaa agtgaagttg tttgatatgg tctacttctt ttttggaatt tcctgaccat     4680

taattaaaga attggatttg caagtttgaa aactggaaaa gcaagagatg ggatgccata     4740

atagtaaaca gcccttgtgt tggatgtaac ccaatcccag atttgagtgt gtgttgatta     4800

tttttttgtc ttccactttt ctattatgtg taaatcactt ttatttctgc agacattttc     4860

ctctcagata ggatgacatt ttgttttgta ttattttgtc tttcctcatg aatgcactga     4920

taatatttta aatgctctat tttaagatct cttgaatctg tttttttttt ttttaatttg     4980

ggggttctgt aaggtcttta tttcccataa gtaaatattg ccatgggagg ggggtggagg     5040

tggcaaggaa ggggtgaagt gctagtatgc aagtgggcag caattatttt tgtgttaatc     5100

agcagtacaa tttgatcgtt ggcatggtta aaaaatggaa tataagatta gctgttttgt     5160

attttgatga ccaattacgc tgtattttaa cacgatgtat gtctgttttt gtggtgctct     5220

agtggtaaat aaattatttc gatgatatgt ggatgtcttt ttcctatcag taccatcatc     5280

gagtctagaa aacacctgtg atgcaataag actatctcaa gctggaaaag tcataccacc     5340

tttccgattg ccctctgtgc tttctccctt aaggacagtc acttcagaag tcatgcttta     5400

aagcacaaga gtcaggccat atccatcaag gatagaagaa atccctgtgc cgtcttttta     5460

ttcccttatt tattgctatt tggtaattgt ttgagattta gtttccatcc agcttgactg     5520

ccgaccagaa aaaatgcaga gagatgtttg caccatgctt tggctttctg gttctatgtt     5580

ctgccaacgc cagggccaaa agaactggtc tagacagtat cccctgtagc cccataactt     5640

ggatagttgc tgagccagcc agatataaca agagccacgt gctttctggg gttggttgtt     5700

tgggatcagc tacttgcctg tcagtttcac tggtaccact gcaccacaaa caaaaaaacc     5760

caccctattt cctccaattt ttttggctgc tacctacaag accagactcc tcaaacgagt     5820

tgccaatctc ttaataaata ggattaataa aaaaagtaat tgtgactcaa aaaaaaaaaa     5880

aa                                                                    5882


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  3
caaagtattt ggtctcc                                                      17


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  4
acctccttgg cgtagta                                                      17


<210>  5
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  5
acctccttgg cgtagta                                                      17


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  6
cctccttggc gtagta                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  7
cctccttggc gtagta                                                       16


<210>  8
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  8
ctccttggcg tagta                                                        15


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  9
ctccttggcg tagta                                                        15


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  10
ctccttggcg tagta                                                        15


<210>  11
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  11
tccttggcgt agta                                                         14


<210>  12
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  12
cagaagttgg cat                                                          13


<210>  13
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  13
cagaagttgg cat                                                          13


<210>  14
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  14
ctgcccgcgg at                                                           12


<210>  15
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  15
tctgcccgcg gat                                                          13


<210>  16
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  16
tcgcgctcgc aggc                                                         14


<210>  17
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  17
ggatctgccc gcgga                                                        15


<210>  18
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  18
ggatctgccc gcgga                                                        15


<210>  19
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  19
cgatcctctt gcgcat                                                       16


<210>  20
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  20
ggcgggatgg cat                                                          13


<210>  21
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  21
gaccagatgc agga                                                         14


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  22
cttgctcagg atctgcc                                                      17


<210>  23
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  23
tctgtaggag ggc                                                          13


<210>  24
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  24
ccttaagcca tccatga                                                      17


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  25
tctgaactag taccgcc                                                      17


<210>  26
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  26
tactattatg gcatccc                                                      17


<210>  27
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  27
agcgtaattg gtcatca                                                      17


<210>  28
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  28
gcgaccgtga ccagat                                                       16


<210>  29
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  29
aactagtacc gccttt                                                       16


<210>  30
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  30
gcgcgaccgt gacc                                                         14


<210>  31
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  31
accactagag cacc                                                         14


<210>  32
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  32
agcgcgaccg tga                                                          13


<210>  33
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  33
ggatcgcctc gat                                                          13


<210>  34
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  34
ctagtaccgc ctt                                                          13


<210>  35
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  35
ccgcggatcg cc                                                           12


<210>  36
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  36
gaccgtgacc agat                                                         14


<210>  37
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically constructed human TGF-beta antisense 
       oligonucleotide

<400>  37
gaccgtgacc agat                                                         14


