                         SEQUENCE LISTING

<110>  Synaffix B.V.
 
<120>  Novel enymes for trimming of glycoproteins

<130>  P6063916PCT

<150>  EP16206867.0
<151>  2016-12-23

<150>  EP16154712.0
<151>  2016-02-08

<150>  EP16173599.8
<151>  2016-06-08

<150>  JP2016-155927
<151>  2016-08-08

<150>  EP16173595.6
<151>  2016-06-08

<150>  JP2016-155929
<151>  2016-08-08

<150>  EP16154739.3
<151>  2016-02-08

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  1258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS-EndoH

<400>  1

Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys 
1               5                   10                  15      


Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val 
            20                  25                  30          


Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu 
        35                  40                  45              


Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His 
    50                  55                  60                  


Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser 
65                  70                  75                  80  


Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys 
                85                  90                  95      


Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys 
        115                 120                 125             


Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly 
    130                 135                 140                 


Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr 
145                 150                 155                 160 


Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val 
                165                 170                 175     


Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser 
            180                 185                 190         


Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser 
        195                 200                 205             


Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val 
    210                 215                 220                 


Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys 
225                 230                 235                 240 


Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val 
                245                 250                 255     


Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser 
            260                 265                 270         


Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys 
        275                 280                 285             


Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu 
    290                 295                 300                 


Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp 
305                 310                 315                 320 


Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala 
                325                 330                 335     


Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly 
            340                 345                 350         


Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys 
        355                 360                 365             


Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe 
    370                 375                 380                 


His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys 
385                 390                 395                 400 


Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala 
                405                 410                 415     


Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu 
            420                 425                 430         


Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser 
        435                 440                 445             


Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile 
    450                 455                 460                 


Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn 
465                 470                 475                 480 


Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys 
                485                 490                 495     


Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp 
        515                 520                 525             


Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu 
    530                 535                 540                 


Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu 
545                 550                 555                 560 


Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val 
                565                 570                 575     


Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly 
            580                 585                 590         


His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala 
        595                 600                 605             


Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr 
    610                 615                 620                 


Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln 
625                 630                 635                 640 


Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr 
                645                 650                 655     


Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp 
            660                 665                 670         


Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu 
        675                 680                 685             


Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala 
    690                 695                 700                 


Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val 
705                 710                 715                 720 


Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val 
                725                 730                 735     


Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn 
            740                 745                 750         


Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys 
        755                 760                 765             


Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg 
    770                 775                 780                 


Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile 
785                 790                 795                 800 


Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn 
                805                 810                 815     


Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala 
            820                 825                 830         


Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr 
        835                 840                 845             


Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser 
    850                 855                 860                 


Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn 
865                 870                 875                 880 


Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln 
                885                 890                 895     


Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys 
            900                 905                 910         


Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr 
        915                 920                 925             


Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg 
    930                 935                 940                 


Gln Leu Leu Lys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly 
                965                 970                 975     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Val 
            980                 985                 990         


Lys Gln Gly Pro Thr Ser Val Ala  Tyr Val Glu Val Asn  Asn Asn Ser 
        995                 1000                 1005             


Met Leu  Asn Val Gly Lys Tyr  Thr Leu Ala Asp Gly  Gly Gly Asn 
    1010                 1015                 1020             


Ala Phe  Asp Val Ala Val Ile  Phe Ala Ala Asn Ile  Asn Tyr Asp 
    1025                 1030                 1035             


Thr Gly  Thr Lys Thr Ala Tyr  Leu His Phe Asn Glu  Asn Val Gln 
    1040                 1045                 1050             


Arg Val  Leu Asp Asn Ala Val  Thr Gln Ile Arg Pro  Leu Gln Gln 
    1055                 1060                 1065             


Gln Gly  Ile Lys Val Leu Leu  Ser Val Leu Gly Asn  His Gln Gly 
    1070                 1075                 1080             


Ala Gly  Phe Ala Asn Phe Pro  Ser Gln Gln Ala Ala  Ser Ala Phe 
    1085                 1090                 1095             


Ala Lys  Gln Leu Ser Asp Ala  Val Ala Lys Tyr Gly  Leu Asp Gly 
    1100                 1105                 1110             


Val Asp  Phe Asp Asp Glu Tyr  Ala Glu Tyr Gly Asn  Asn Gly Thr 
    1115                 1120                 1125             


Ala Gln  Pro Asn Asp Ser Ser  Phe Val His Leu Val  Thr Ala Leu 
    1130                 1135                 1140             


Arg Ala  Asn Met Pro Asp Lys  Ile Ile Ser Leu Tyr  Asn Ile Gly 
    1145                 1150                 1155             


Pro Ala  Ala Ser Arg Leu Ser  Tyr Gly Gly Val Asp  Val Ser Asp 
    1160                 1165                 1170             


Lys Phe  Asp Tyr Ala Trp Asn  Pro Tyr Tyr Gly Thr  Trp Gln Val 
    1175                 1180                 1185             


Pro Gly  Ile Ala Leu Pro Lys  Ala Gln Leu Ser Pro  Ala Ala Val 
    1190                 1195                 1200             


Glu Ile  Gly Arg Thr Ser Arg  Ser Thr Val Ala Asp  Leu Ala Arg 
    1205                 1210                 1215             


Arg Thr  Val Asp Glu Gly Tyr  Gly Val Tyr Leu Thr  Tyr Asn Leu 
    1220                 1225                 1230             


Asp Gly  Gly Asp Arg Thr Ala  Asp Val Ser Ala Phe  Thr Arg Glu 
    1235                 1240                 1245             


Leu Tyr  Gly Ser Glu Ala Val  Arg Thr Pro 
    1250                 1255             


<210>  2
<211>  1256
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS-EndoH

<400>  2

Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys 
1               5                   10                  15      


Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val 
            20                  25                  30          


Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu 
        35                  40                  45              


Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His 
    50                  55                  60                  


Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser 
65                  70                  75                  80  


Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys 
                85                  90                  95      


Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys 
        115                 120                 125             


Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly 
    130                 135                 140                 


Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr 
145                 150                 155                 160 


Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val 
                165                 170                 175     


Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser 
            180                 185                 190         


Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser 
        195                 200                 205             


Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val 
    210                 215                 220                 


Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys 
225                 230                 235                 240 


Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val 
                245                 250                 255     


Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser 
            260                 265                 270         


Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys 
        275                 280                 285             


Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu 
    290                 295                 300                 


Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp 
305                 310                 315                 320 


Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala 
                325                 330                 335     


Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly 
            340                 345                 350         


Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys 
        355                 360                 365             


Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe 
    370                 375                 380                 


His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys 
385                 390                 395                 400 


Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala 
                405                 410                 415     


Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu 
            420                 425                 430         


Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser 
        435                 440                 445             


Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile 
    450                 455                 460                 


Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn 
465                 470                 475                 480 


Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys 
                485                 490                 495     


Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp 
        515                 520                 525             


Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu 
    530                 535                 540                 


Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu 
545                 550                 555                 560 


Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val 
                565                 570                 575     


Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly 
            580                 585                 590         


His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala 
        595                 600                 605             


Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr 
    610                 615                 620                 


Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln 
625                 630                 635                 640 


Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr 
                645                 650                 655     


Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp 
            660                 665                 670         


Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu 
        675                 680                 685             


Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala 
    690                 695                 700                 


Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val 
705                 710                 715                 720 


Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val 
                725                 730                 735     


Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn 
            740                 745                 750         


Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys 
        755                 760                 765             


Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg 
    770                 775                 780                 


Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile 
785                 790                 795                 800 


Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn 
                805                 810                 815     


Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala 
            820                 825                 830         


Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr 
        835                 840                 845             


Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser 
    850                 855                 860                 


Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn 
865                 870                 875                 880 


Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln 
                885                 890                 895     


Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys 
            900                 905                 910         


Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr 
        915                 920                 925             


Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg 
    930                 935                 940                 


Gln Leu Leu Lys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser His His His His His His Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Val Lys Gln 
            980                 985                 990         


Gly Pro Thr Ser Val Ala Tyr Val  Glu Val Asn Asn Asn  Ser Met Leu 
        995                 1000                 1005             


Asn Val  Gly Lys Tyr Thr Leu  Ala Asp Gly Gly Gly  Asn Ala Phe 
    1010                 1015                 1020             


Asp Val  Ala Val Ile Phe Ala  Ala Asn Ile Asn Tyr  Asp Thr Gly 
    1025                 1030                 1035             


Thr Lys  Thr Ala Tyr Leu His  Phe Asn Glu Asn Val  Gln Arg Val 
    1040                 1045                 1050             


Leu Asp  Asn Ala Val Thr Gln  Ile Arg Pro Leu Gln  Gln Gln Gly 
    1055                 1060                 1065             


Ile Lys  Val Leu Leu Ser Val  Leu Gly Asn His Gln  Gly Ala Gly 
    1070                 1075                 1080             


Phe Ala  Asn Phe Pro Ser Gln  Gln Ala Ala Ser Ala  Phe Ala Lys 
    1085                 1090                 1095             


Gln Leu  Ser Asp Ala Val Ala  Lys Tyr Gly Leu Asp  Gly Val Asp 
    1100                 1105                 1110             


Phe Asp  Asp Glu Tyr Ala Glu  Tyr Gly Asn Asn Gly  Thr Ala Gln 
    1115                 1120                 1125             


Pro Asn  Asp Ser Ser Phe Val  His Leu Val Thr Ala  Leu Arg Ala 
    1130                 1135                 1140             


Asn Met  Pro Asp Lys Ile Ile  Ser Leu Tyr Asn Ile  Gly Pro Ala 
    1145                 1150                 1155             


Ala Ser  Arg Leu Ser Tyr Gly  Gly Val Asp Val Ser  Asp Lys Phe 
    1160                 1165                 1170             


Asp Tyr  Ala Trp Asn Pro Tyr  Tyr Gly Thr Trp Gln  Val Pro Gly 
    1175                 1180                 1185             


Ile Ala  Leu Pro Lys Ala Gln  Leu Ser Pro Ala Ala  Val Glu Ile 
    1190                 1195                 1200             


Gly Arg  Thr Ser Arg Ser Thr  Val Ala Asp Leu Ala  Arg Arg Thr 
    1205                 1210                 1215             


Val Asp  Glu Gly Tyr Gly Val  Tyr Leu Thr Tyr Asn  Leu Asp Gly 
    1220                 1225                 1230             


Gly Asp  Arg Thr Ala Asp Val  Ser Ala Phe Thr Arg  Glu Leu Tyr 
    1235                 1240                 1245             


Gly Ser  Glu Ala Val Arg Thr  Pro 
    1250                 1255     


<210>  3
<211>  410
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His-TnGalNAcT(33-421)

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  4
<211>  949
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS

<400>  4

Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys 
1               5                   10                  15      


Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val 
            20                  25                  30          


Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu 
        35                  40                  45              


Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His 
    50                  55                  60                  


Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser 
65                  70                  75                  80  


Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys 
                85                  90                  95      


Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys 
        115                 120                 125             


Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly 
    130                 135                 140                 


Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr 
145                 150                 155                 160 


Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val 
                165                 170                 175     


Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser 
            180                 185                 190         


Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser 
        195                 200                 205             


Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val 
    210                 215                 220                 


Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys 
225                 230                 235                 240 


Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val 
                245                 250                 255     


Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser 
            260                 265                 270         


Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys 
        275                 280                 285             


Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu 
    290                 295                 300                 


Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp 
305                 310                 315                 320 


Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala 
                325                 330                 335     


Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly 
            340                 345                 350         


Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys 
        355                 360                 365             


Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe 
    370                 375                 380                 


His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys 
385                 390                 395                 400 


Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala 
                405                 410                 415     


Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu 
            420                 425                 430         


Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser 
        435                 440                 445             


Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile 
    450                 455                 460                 


Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn 
465                 470                 475                 480 


Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys 
                485                 490                 495     


Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp 
        515                 520                 525             


Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu 
    530                 535                 540                 


Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu 
545                 550                 555                 560 


Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val 
                565                 570                 575     


Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly 
            580                 585                 590         


His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala 
        595                 600                 605             


Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr 
    610                 615                 620                 


Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln 
625                 630                 635                 640 


Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr 
                645                 650                 655     


Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp 
            660                 665                 670         


Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu 
        675                 680                 685             


Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala 
    690                 695                 700                 


Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val 
705                 710                 715                 720 


Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val 
                725                 730                 735     


Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn 
            740                 745                 750         


Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys 
        755                 760                 765             


Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg 
    770                 775                 780                 


Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile 
785                 790                 795                 800 


Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn 
                805                 810                 815     


Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala 
            820                 825                 830         


Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr 
        835                 840                 845             


Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser 
    850                 855                 860                 


Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn 
865                 870                 875                 880 


Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln 
                885                 890                 895     


Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys 
            900                 905                 910         


Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr 
        915                 920                 925             


Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg 
    930                 935                 940                 


Gln Leu Leu Lys Lys 
945                 


<210>  5
<211>  969
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS 2

<400>  5

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu 
            20                  25                  30          


Asn Ser Lys Lys Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu 
        35                  40                  45              


Ser Gln Lys Val Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys 
    50                  55                  60                  


Gln Ala Gln Glu Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met 
65                  70                  75                  80  


Lys Pro Leu His Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His 
                85                  90                  95      


Asp Lys Thr Ser Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly 
            100                 105                 110         


Glu Leu Pro Lys Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr 
        115                 120                 125             


Lys Asp Tyr Ser Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro 
    130                 135                 140                 


Lys Leu Asn Lys Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg 
145                 150                 155                 160 


Phe Leu Ala Gly Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys 
                165                 170                 175     


Tyr Pro Asn Thr Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val 
            180                 185                 190         


Asp Glu Tyr Val Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val 
        195                 200                 205             


Glu His Asp Ser Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly 
    210                 215                 220                 


Val Glu Arg Ser Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly 
225                 230                 235                 240 


Pro Lys Gly Val Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr 
                245                 250                 255     


Met Ala Asp Lys Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn 
            260                 265                 270         


Leu Leu Leu Val Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp 
        275                 280                 285             


Glu Pro Val Ser Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln 
    290                 295                 300                 


Gly Tyr Ser Lys Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser 
305                 310                 315                 320 


Phe Tyr Glu Glu Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn 
                325                 330                 335     


Ser Arg Lys Asp Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr 
            340                 345                 350         


Gly Thr Arg Ala Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly 
        355                 360                 365             


Val Lys Gly Gly Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala 
    370                 375                 380                 


His Gln Pro Lys Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr 
385                 390                 395                 400 


Asp Asn Ile Phe His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr 
                405                 410                 415     


Val Met Leu Lys Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe 
            420                 425                 430         


Pro Asp Lys Ala Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg 
        435                 440                 445             


Lys Gly Asp Leu Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro 
    450                 455                 460                 


Ala Ile Gln Ser Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln 
465                 470                 475                 480 


Leu Asp Leu Ile Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val 
                485                 490                 495     


Leu Pro Ala Asn Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu 
            500                 505                 510         


Glu Thr Tyr Lys Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro 
        515                 520                 525             


Val Ser Leu Lys Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu 
    530                 535                 540                 


Ser Gly Phe Asp Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu 
545                 550                 555                 560 


Thr Ser Leu Glu Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala 
                565                 570                 575     


Pro Gly Thr Glu Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile 
            580                 585                 590         


Ser Asn His Val Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln 
        595                 600                 605             


Lys Pro Thr Gly His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg 
    610                 615                 620                 


Leu Pro Val Ala Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe 
625                 630                 635                 640 


Gly Thr Val Thr Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr 
                645                 650                 655     


Lys Ala Tyr Gln Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser 
            660                 665                 670         


Asn Tyr His Tyr Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val 
        675                 680                 685             


Lys Val Thr Asp Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala 
    690                 695                 700                 


Thr Asp Lys Glu Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp 
705                 710                 715                 720 


Lys Thr Lys Ala Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys 
                725                 730                 735     


Thr Met Met Val Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser 
            740                 745                 750         


Ala Asp Pro Val Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser 
        755                 760                 765             


Glu Thr Asp Asn Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile 
    770                 775                 780                 


Phe Lys Leu Lys Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn 
785                 790                 795                 800 


Asp Ser Ala Arg Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala 
                805                 810                 815     


Ser Leu Gln Ile Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu 
            820                 825                 830         


Glu Asn Pro Asn Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp 
        835                 840                 845             


Thr Tyr Ser Ala Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu 
    850                 855                 860                 


Asn Asn Ile Thr Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly 
865                 870                 875                 880 


Asp Arg Tyr Ser Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr 
                885                 890                 895     


Pro Leu Pro Asn Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys 
            900                 905                 910         


Glu Leu Ser Gln Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu 
        915                 920                 925             


Leu Lys Ile Lys Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile 
    930                 935                 940                 


Phe Asp Val Thr Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys 
945                 950                 955                 960 


Ile Glu Lys Arg Gln Leu Leu Lys Lys 
                965                 


<210>  6
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoH

<400>  6

Ala Pro Ala Pro Val Lys Gln Gly Pro Thr Ser Val Ala Tyr Val Glu 
1               5                   10                  15      


Val Asn Asn Asn Ser Met Leu Asn Val Gly Lys Tyr Thr Leu Ala Asp 
            20                  25                  30          


Gly Gly Gly Asn Ala Phe Asp Val Ala Val Ile Phe Ala Ala Asn Ile 
        35                  40                  45              


Asn Tyr Asp Thr Gly Thr Lys Thr Ala Tyr Leu His Phe Asn Glu Asn 
    50                  55                  60                  


Val Gln Arg Val Leu Asp Asn Ala Val Thr Gln Ile Arg Pro Leu Gln 
65                  70                  75                  80  


Gln Gln Gly Ile Lys Val Leu Leu Ser Val Leu Gly Asn His Gln Gly 
                85                  90                  95      


Ala Gly Phe Ala Asn Phe Pro Ser Gln Gln Ala Ala Ser Ala Phe Ala 
            100                 105                 110         


Lys Gln Leu Ser Asp Ala Val Ala Lys Tyr Gly Leu Asp Gly Val Asp 
        115                 120                 125             


Phe Asp Asp Glu Tyr Ala Glu Tyr Gly Asn Asn Gly Thr Ala Gln Pro 
    130                 135                 140                 


Asn Asp Ser Ser Phe Val His Leu Val Thr Ala Leu Arg Ala Asn Met 
145                 150                 155                 160 


Pro Asp Lys Ile Ile Ser Leu Tyr Asn Ile Gly Pro Ala Ala Ser Arg 
                165                 170                 175     


Leu Ser Tyr Gly Gly Val Asp Val Ser Asp Lys Phe Asp Tyr Ala Trp 
            180                 185                 190         


Asn Pro Tyr Tyr Gly Thr Trp Gln Val Pro Gly Ile Ala Leu Pro Lys 
        195                 200                 205             


Ala Gln Leu Ser Pro Ala Ala Val Glu Ile Gly Arg Thr Ser Arg Ser 
    210                 215                 220                 


Thr Val Ala Asp Leu Ala Arg Arg Thr Val Asp Glu Gly Tyr Gly Val 
225                 230                 235                 240 


Tyr Leu Thr Tyr Asn Leu Asp Gly Gly Asp Arg Thr Ala Asp Val Ser 
                245                 250                 255     


Ala Phe Thr Arg Glu Leu Tyr Gly Ser Glu Ala Val Arg Thr Pro 
            260                 265                 270     


<210>  7
<211>  289
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF1

<400>  7

Ala Val Thr Gly Thr Thr Lys Ala Asn Ile Lys Leu Phe Ser Phe Thr 
1               5                   10                  15      


Glu Val Asn Asp Thr Asn Pro Leu Asn Asn Leu Asn Phe Thr Leu Lys 
            20                  25                  30          


Asn Ser Gly Lys Pro Leu Val Asp Met Val Val Leu Phe Ser Ala Asn 
        35                  40                  45              


Ile Asn Tyr Asp Ala Ala Asn Asp Lys Val Phe Val Ser Asn Asn Pro 
    50                  55                  60                  


Asn Val Gln His Leu Leu Thr Asn Arg Ala Lys Tyr Leu Lys Pro Leu 
65                  70                  75                  80  


Gln Asp Lys Gly Ile Lys Val Ile Leu Ser Ile Leu Gly Asn His Asp 
                85                  90                  95      


Arg Ser Gly Ile Ala Asn Leu Ser Thr Ala Arg Ala Lys Ala Phe Ala 
            100                 105                 110         


Gln Glu Leu Lys Asn Thr Cys Asp Leu Tyr Asn Leu Asp Gly Val Phe 
        115                 120                 125             


Phe Asp Asp Glu Tyr Ser Ala Tyr Gln Thr Pro Pro Pro Ser Gly Phe 
    130                 135                 140                 


Val Thr Pro Ser Asn Asn Ala Ala Ala Arg Leu Ala Tyr Glu Thr Lys 
145                 150                 155                 160 


Gln Ala Met Pro Asn Lys Leu Val Thr Val Tyr Val Tyr Ser Arg Thr 
                165                 170                 175     


Ser Ser Phe Pro Thr Ala Val Asp Gly Val Asn Ala Gly Ser Tyr Val 
            180                 185                 190         


Asp Tyr Ala Ile His Asp Tyr Gly Gly Ser Tyr Asp Leu Ala Thr Asn 
        195                 200                 205             


Tyr Pro Gly Leu Ala Lys Ser Gly Met Val Met Ser Ser Gln Glu Phe 
    210                 215                 220                 


Asn Gln Gly Arg Tyr Ala Thr Ala Gln Ala Leu Arg Asn Ile Val Thr 
225                 230                 235                 240 


Lys Gly Tyr Gly Gly His Met Ile Phe Ala Met Asp Pro Asn Arg Ser 
                245                 250                 255     


Asn Phe Thr Ser Gly Gln Leu Pro Ala Leu Lys Leu Ile Ala Lys Glu 
            260                 265                 270         


Leu Tyr Gly Asp Glu Leu Val Tyr Ser Asn Thr Pro Tyr Ser Lys Asp 
        275                 280                 285             


Trp 
    


<210>  8
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF2

<400>  8

Met Ala Val Asn Leu Ser Asn Leu Ile Ala Tyr Lys Asn Ser Asp His 
1               5                   10                  15      


Gln Ile Ser Ala Gly Tyr Tyr Arg Thr Trp Arg Asp Ser Ala Thr Ala 
            20                  25                  30          


Ser Gly Asn Leu Pro Ser Met Arg Trp Leu Pro Asp Ser Leu Asp Met 
        35                  40                  45              


Val Met Val Phe Pro Asp Tyr Thr Pro Pro Glu Asn Ala Tyr Trp Asn 
    50                  55                  60                  


Thr Leu Lys Thr Asn Tyr Val Pro Tyr Leu His Lys Arg Gly Thr Lys 
65                  70                  75                  80  


Val Ile Ile Thr Leu Gly Asp Leu Asn Ser Ala Thr Thr Thr Gly Gly 
                85                  90                  95      


Gln Asp Ser Ile Gly Tyr Ser Ser Trp Ala Lys Gly Ile Tyr Asp Lys 
            100                 105                 110         


Trp Val Gly Glu Tyr Asn Leu Asp Gly Ile Asp Ile Asp Ile Glu Ser 
        115                 120                 125             


Ser Pro Ser Gly Ala Thr Leu Thr Lys Phe Val Ala Ala Thr Lys Ala 
    130                 135                 140                 


Leu Ser Lys Tyr Phe Gly Pro Lys Ser Gly Thr Gly Lys Thr Phe Val 
145                 150                 155                 160 


Tyr Asp Thr Asn Gln Asn Pro Thr Asn Phe Phe Ile Gln Thr Ala Pro 
                165                 170                 175     


Arg Tyr Asn Tyr Val Phe Leu Gln Ala Tyr Gly Arg Ser Thr Thr Asn 
            180                 185                 190         


Leu Thr Thr Val Ser Gly Leu Tyr Ala Pro Tyr Ile Ser Met Lys Gln 
        195                 200                 205             


Phe Leu Pro Gly Phe Ser Phe Tyr Glu Glu Asn Gly Tyr Pro Gly Asn 
    210                 215                 220                 


Tyr Trp Asn Asp Val Arg Tyr Pro Gln Asn Gly Thr Gly Arg Ala Tyr 
225                 230                 235                 240 


Asp Tyr Ala Arg Trp Gln Pro Ala Thr Gly Lys Lys Gly Gly Val Phe 
                245                 250                 255     


Ser Tyr Ala Ile Glu Arg Asp Ala Pro Leu Thr Ser Ser Asn Asp Asn 
            260                 265                 270         


Thr Leu Arg Ala Pro Asn Phe Arg Val Thr Lys Asp Leu Ile Lys Ile 
        275                 280                 285             


Met Asn Pro 
    290     


<210>  9
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF3

<400>  9

Met Ala Thr Ala Leu Ala Gly Ser Asn Gly Val Cys Ile Ala Tyr Tyr 
1               5                   10                  15      


Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys Leu Lys Asp Ile Pro Asp 
            20                  25                  30          


Lys Val Asp Met Val Ile Leu Phe Gly Leu Lys Tyr Trp Ser Leu Gln 
        35                  40                  45              


Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly Met Met Gly Ser Phe Lys 
    50                  55                  60                  


Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg Ser Leu Gln Ser Arg Gly 
65                  70                  75                  80  


Ile Lys Val Leu Gln Asn Ile Asp Asp Asp Val Ser Trp Gln Ser Ser 
                85                  90                  95      


Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala Tyr Gly Asp Ala Ile Lys 
            100                 105                 110         


Ser Ile Val Ile Asp Lys Trp Lys Leu Asp Gly Ile Ser Leu Asp Ile 
        115                 120                 125             


Glu His Ser Gly Ala Lys Pro Asn Pro Ile Pro Thr Phe Pro Gly Tyr 
    130                 135                 140                 


Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser Gly Ser Met Ala Ala Thr 
145                 150                 155                 160 


Pro Ala Phe Leu Asn Val Ile Ser Glu Leu Thr Lys Tyr Phe Gly Thr 
                165                 170                 175     


Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile Ala Ser Gly Ile Asp Val 
            180                 185                 190         


Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe Arg Asn Asn Phe Asn Tyr 
        195                 200                 205             


Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val Ser Arg Thr Gln Leu Met 
    210                 215                 220                 


Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile Pro Ala Ser Lys Met Val 
225                 230                 235                 240 


Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn Gln Ala Asn Asp Val Glu 
                245                 250                 255     


Val Ala Lys Trp Thr Pro Thr Gln Gly Ala Lys Gly Gly Met Met Ile 
            260                 265                 270         


Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala Asn Ala Val Arg Asp Ala 
        275                 280                 285             


Val Lys Asn 
    290     


<210>  10
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EfEndo18A

<400>  10

Ala Ser Thr Val Thr Pro Lys Thr Val Met Tyr Val Glu Val Asn Asn 
1               5                   10                  15      


His Asp Phe Asn Asn Val Gly Lys Tyr Thr Leu Ala Gly Thr Asn Gln 
            20                  25                  30          


Pro Ala Phe Asp Met Gly Ile Ile Phe Ala Ala Asn Ile Asn Tyr Asp 
        35                  40                  45              


Thr Val Asn Lys Lys Pro Tyr Leu Tyr Leu Asn Glu Arg Val Gln Gln 
    50                  55                  60                  


Thr Leu Asn Glu Ala Glu Thr Gln Ile Arg Pro Val Gln Ala Arg Gly 
65                  70                  75                  80  


Thr Lys Val Leu Leu Ser Ile Leu Gly Asn His Glu Gly Ala Gly Phe 
                85                  90                  95      


Ala Asn Phe Pro Thr Tyr Glu Ser Ala Asp Ala Phe Ala Ala Gln Leu 
            100                 105                 110         


Glu Gln Val Val Asn Thr Tyr His Leu Asp Gly Ile Asp Phe Asp Asp 
        115                 120                 125             


Glu Tyr Ala Glu Tyr Gly Lys Asn Gly Thr Pro Gln Pro Asn Asn Ser 
    130                 135                 140                 


Ser Phe Ile Trp Leu Leu Gln Ala Leu Arg Asn Arg Leu Gly Asn Asp 
145                 150                 155                 160 


Lys Leu Ile Thr Phe Tyr Asn Ile Gly Pro Ala Ala Ala Asn Ser Ser 
                165                 170                 175     


Ala Asn Pro Gln Met Ser Ser Leu Ile Asp Tyr Ala Trp Asn Pro Tyr 
            180                 185                 190         


Tyr Ser Thr Trp Asn Pro Pro Gln Ile Ala Gly Met Pro Ala Ser Arg 
        195                 200                 205             


Leu Gly Ala Ser Ala Val Glu Val Gly Val Asn Gln Asn Leu Ala Ala 
    210                 215                 220                 


Gln Tyr Ala Lys Arg Thr Lys Ala Glu Gln Tyr Gly Ile Tyr Leu Met 
225                 230                 235                 240 


Tyr Asn Leu Pro Gly Lys Asp Ser Ser Ala Tyr Ile Ser Ala Ala Thr 
                245                 250                 255     


Gln Glu Leu Tyr Gly Arg Lys Thr Asn Tyr Ser Pro Thr Val Pro Thr 
            260                 265                 270         


Pro 
    


<210>  11
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
1               5                   10                  15      


His His His His His Glu Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser 
        35              


<210>  12
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
1               5                   10                  15      


His His His His His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  13
<211>  602
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF3-EfEndo18A

<400>  13

Met Ala Thr Ala Leu Ala Gly Ser Asn Gly Val Cys Ile Ala Tyr Tyr 
1               5                   10                  15      


Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys Leu Lys Asp Ile Pro Asp 
            20                  25                  30          


Lys Val Asp Met Val Ile Leu Phe Gly Leu Lys Tyr Trp Ser Leu Gln 
        35                  40                  45              


Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly Met Met Gly Ser Phe Lys 
    50                  55                  60                  


Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg Ser Leu Gln Ser Arg Gly 
65                  70                  75                  80  


Ile Lys Val Leu Gln Asn Ile Asp Asp Asp Val Ser Trp Gln Ser Ser 
                85                  90                  95      


Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala Tyr Gly Asp Ala Ile Lys 
            100                 105                 110         


Ser Ile Val Ile Asp Lys Trp Lys Leu Asp Gly Ile Ser Leu Asp Ile 
        115                 120                 125             


Glu His Ser Gly Ala Lys Pro Asn Pro Ile Pro Thr Phe Pro Gly Tyr 
    130                 135                 140                 


Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser Gly Ser Met Ala Ala Thr 
145                 150                 155                 160 


Pro Ala Phe Leu Asn Val Ile Ser Glu Leu Thr Lys Tyr Phe Gly Thr 
                165                 170                 175     


Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile Ala Ser Gly Ile Asp Val 
            180                 185                 190         


Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe Arg Asn Asn Phe Asn Tyr 
        195                 200                 205             


Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val Ser Arg Thr Gln Leu Met 
    210                 215                 220                 


Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile Pro Ala Ser Lys Met Val 
225                 230                 235                 240 


Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn Gln Ala Asn Asp Val Glu 
                245                 250                 255     


Val Ala Lys Trp Thr Pro Thr Gln Gly Ala Lys Gly Gly Met Met Ile 
            260                 265                 270         


Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala Asn Ala Val Arg Asp Ala 
        275                 280                 285             


Val Lys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Val Thr Pro Lys 
                325                 330                 335     


Thr Val Met Tyr Val Glu Val Asn Asn His Asp Phe Asn Asn Val Gly 
            340                 345                 350         


Lys Tyr Thr Leu Ala Gly Thr Asn Gln Pro Ala Phe Asp Met Gly Ile 
        355                 360                 365             


Ile Phe Ala Ala Asn Ile Asn Tyr Asp Thr Val Asn Lys Lys Pro Tyr 
    370                 375                 380                 


Leu Tyr Leu Asn Glu Arg Val Gln Gln Thr Leu Asn Glu Ala Glu Thr 
385                 390                 395                 400 


Gln Ile Arg Pro Val Gln Ala Arg Gly Thr Lys Val Leu Leu Ser Ile 
                405                 410                 415     


Leu Gly Asn His Glu Gly Ala Gly Phe Ala Asn Phe Pro Thr Tyr Glu 
            420                 425                 430         


Ser Ala Asp Ala Phe Ala Ala Gln Leu Glu Gln Val Val Asn Thr Tyr 
        435                 440                 445             


His Leu Asp Gly Ile Asp Phe Asp Asp Glu Tyr Ala Glu Tyr Gly Lys 
    450                 455                 460                 


Asn Gly Thr Pro Gln Pro Asn Asn Ser Ser Phe Ile Trp Leu Leu Gln 
465                 470                 475                 480 


Ala Leu Arg Asn Arg Leu Gly Asn Asp Lys Leu Ile Thr Phe Tyr Asn 
                485                 490                 495     


Ile Gly Pro Ala Ala Ala Asn Ser Ser Ala Asn Pro Gln Met Ser Ser 
            500                 505                 510         


Leu Ile Asp Tyr Ala Trp Asn Pro Tyr Tyr Ser Thr Trp Asn Pro Pro 
        515                 520                 525             


Gln Ile Ala Gly Met Pro Ala Ser Arg Leu Gly Ala Ser Ala Val Glu 
    530                 535                 540                 


Val Gly Val Asn Gln Asn Leu Ala Ala Gln Tyr Ala Lys Arg Thr Lys 
545                 550                 555                 560 


Ala Glu Gln Tyr Gly Ile Tyr Leu Met Tyr Asn Leu Pro Gly Lys Asp 
                565                 570                 575     


Ser Ser Ala Tyr Ile Ser Ala Ala Thr Gln Glu Leu Tyr Gly Arg Lys 
            580                 585                 590         


Thr Asn Tyr Ser Pro Thr Val Pro Thr Pro 
        595                 600         


<210>  14
<211>  602
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF2-EfEndo18A

<400>  14

Met Ala Val Asn Leu Ser Asn Leu Ile Ala Tyr Lys Asn Ser Asp His 
1               5                   10                  15      


Gln Ile Ser Ala Gly Tyr Tyr Arg Thr Trp Arg Asp Ser Ala Thr Ala 
            20                  25                  30          


Ser Gly Asn Leu Pro Ser Met Arg Trp Leu Pro Asp Ser Leu Asp Met 
        35                  40                  45              


Val Met Val Phe Pro Asp Tyr Thr Pro Pro Glu Asn Ala Tyr Trp Asn 
    50                  55                  60                  


Thr Leu Lys Thr Asn Tyr Val Pro Tyr Leu His Lys Arg Gly Thr Lys 
65                  70                  75                  80  


Val Ile Ile Thr Leu Gly Asp Leu Asn Ser Ala Thr Thr Thr Gly Gly 
                85                  90                  95      


Gln Asp Ser Ile Gly Tyr Ser Ser Trp Ala Lys Gly Ile Tyr Asp Lys 
            100                 105                 110         


Trp Val Gly Glu Tyr Asn Leu Asp Gly Ile Asp Ile Asp Ile Glu Ser 
        115                 120                 125             


Ser Pro Ser Gly Ala Thr Leu Thr Lys Phe Val Ala Ala Thr Lys Ala 
    130                 135                 140                 


Leu Ser Lys Tyr Phe Gly Pro Lys Ser Gly Thr Gly Lys Thr Phe Val 
145                 150                 155                 160 


Tyr Asp Thr Asn Gln Asn Pro Thr Asn Phe Phe Ile Gln Thr Ala Pro 
                165                 170                 175     


Arg Tyr Asn Tyr Val Phe Leu Gln Ala Tyr Gly Arg Ser Thr Thr Asn 
            180                 185                 190         


Leu Thr Thr Val Ser Gly Leu Tyr Ala Pro Tyr Ile Ser Met Lys Gln 
        195                 200                 205             


Phe Leu Pro Gly Phe Ser Phe Tyr Glu Glu Asn Gly Tyr Pro Gly Asn 
    210                 215                 220                 


Tyr Trp Asn Asp Val Arg Tyr Pro Gln Asn Gly Thr Gly Arg Ala Tyr 
225                 230                 235                 240 


Asp Tyr Ala Arg Trp Gln Pro Ala Thr Gly Lys Lys Gly Gly Val Phe 
                245                 250                 255     


Ser Tyr Ala Ile Glu Arg Asp Ala Pro Leu Thr Ser Ser Asn Asp Asn 
            260                 265                 270         


Thr Leu Arg Ala Pro Asn Phe Arg Val Thr Lys Asp Leu Ile Lys Ile 
        275                 280                 285             


Met Asn Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Val Thr Pro Lys 
                325                 330                 335     


Thr Val Met Tyr Val Glu Val Asn Asn His Asp Phe Asn Asn Val Gly 
            340                 345                 350         


Lys Tyr Thr Leu Ala Gly Thr Asn Gln Pro Ala Phe Asp Met Gly Ile 
        355                 360                 365             


Ile Phe Ala Ala Asn Ile Asn Tyr Asp Thr Val Asn Lys Lys Pro Tyr 
    370                 375                 380                 


Leu Tyr Leu Asn Glu Arg Val Gln Gln Thr Leu Asn Glu Ala Glu Thr 
385                 390                 395                 400 


Gln Ile Arg Pro Val Gln Ala Arg Gly Thr Lys Val Leu Leu Ser Ile 
                405                 410                 415     


Leu Gly Asn His Glu Gly Ala Gly Phe Ala Asn Phe Pro Thr Tyr Glu 
            420                 425                 430         


Ser Ala Asp Ala Phe Ala Ala Gln Leu Glu Gln Val Val Asn Thr Tyr 
        435                 440                 445             


His Leu Asp Gly Ile Asp Phe Asp Asp Glu Tyr Ala Glu Tyr Gly Lys 
    450                 455                 460                 


Asn Gly Thr Pro Gln Pro Asn Asn Ser Ser Phe Ile Trp Leu Leu Gln 
465                 470                 475                 480 


Ala Leu Arg Asn Arg Leu Gly Asn Asp Lys Leu Ile Thr Phe Tyr Asn 
                485                 490                 495     


Ile Gly Pro Ala Ala Ala Asn Ser Ser Ala Asn Pro Gln Met Ser Ser 
            500                 505                 510         


Leu Ile Asp Tyr Ala Trp Asn Pro Tyr Tyr Ser Thr Trp Asn Pro Pro 
        515                 520                 525             


Gln Ile Ala Gly Met Pro Ala Ser Arg Leu Gly Ala Ser Ala Val Glu 
    530                 535                 540                 


Val Gly Val Asn Gln Asn Leu Ala Ala Gln Tyr Ala Lys Arg Thr Lys 
545                 550                 555                 560 


Ala Glu Gln Tyr Gly Ile Tyr Leu Met Tyr Asn Leu Pro Gly Lys Asp 
                565                 570                 575     


Ser Ser Ala Tyr Ile Ser Ala Ala Thr Gln Glu Leu Tyr Gly Arg Lys 
            580                 585                 590         


Thr Asn Tyr Ser Pro Thr Val Pro Thr Pro 
        595                 600         


<210>  15
<211>  1260
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS-EfEndo18A

<400>  15

Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys 
1               5                   10                  15      


Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val 
            20                  25                  30          


Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu 
        35                  40                  45              


Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His 
    50                  55                  60                  


Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser 
65                  70                  75                  80  


Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys 
                85                  90                  95      


Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys 
        115                 120                 125             


Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly 
    130                 135                 140                 


Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr 
145                 150                 155                 160 


Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val 
                165                 170                 175     


Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser 
            180                 185                 190         


Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser 
        195                 200                 205             


Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val 
    210                 215                 220                 


Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys 
225                 230                 235                 240 


Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val 
                245                 250                 255     


Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser 
            260                 265                 270         


Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys 
        275                 280                 285             


Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu 
    290                 295                 300                 


Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp 
305                 310                 315                 320 


Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala 
                325                 330                 335     


Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly 
            340                 345                 350         


Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys 
        355                 360                 365             


Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe 
    370                 375                 380                 


His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys 
385                 390                 395                 400 


Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala 
                405                 410                 415     


Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu 
            420                 425                 430         


Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser 
        435                 440                 445             


Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile 
    450                 455                 460                 


Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn 
465                 470                 475                 480 


Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys 
                485                 490                 495     


Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp 
        515                 520                 525             


Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu 
    530                 535                 540                 


Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu 
545                 550                 555                 560 


Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val 
                565                 570                 575     


Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly 
            580                 585                 590         


His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala 
        595                 600                 605             


Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr 
    610                 615                 620                 


Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln 
625                 630                 635                 640 


Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr 
                645                 650                 655     


Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp 
            660                 665                 670         


Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu 
        675                 680                 685             


Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala 
    690                 695                 700                 


Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val 
705                 710                 715                 720 


Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val 
                725                 730                 735     


Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn 
            740                 745                 750         


Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys 
        755                 760                 765             


Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg 
    770                 775                 780                 


Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile 
785                 790                 795                 800 


Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn 
                805                 810                 815     


Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala 
            820                 825                 830         


Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr 
        835                 840                 845             


Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser 
    850                 855                 860                 


Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn 
865                 870                 875                 880 


Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln 
                885                 890                 895     


Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys 
            900                 905                 910         


Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr 
        915                 920                 925             


Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg 
    930                 935                 940                 


Gln Leu Leu Lys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly 
                965                 970                 975     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Val Thr 
            980                 985                 990         


Pro Lys Thr Val Met Tyr Val Glu  Val Asn Asn His Asp  Phe Asn Asn 
        995                 1000                 1005             


Val Gly  Lys Tyr Thr Leu Ala  Gly Thr Asn Gln Pro  Ala Phe Asp 
    1010                 1015                 1020             


Met Gly  Ile Ile Phe Ala Ala  Asn Ile Asn Tyr Asp  Thr Val Asn 
    1025                 1030                 1035             


Lys Lys  Pro Tyr Leu Tyr Leu  Asn Glu Arg Val Gln  Gln Thr Leu 
    1040                 1045                 1050             


Asn Glu  Ala Glu Thr Gln Ile  Arg Pro Val Gln Ala  Arg Gly Thr 
    1055                 1060                 1065             


Lys Val  Leu Leu Ser Ile Leu  Gly Asn His Glu Gly  Ala Gly Phe 
    1070                 1075                 1080             


Ala Asn  Phe Pro Thr Tyr Glu  Ser Ala Asp Ala Phe  Ala Ala Gln 
    1085                 1090                 1095             


Leu Glu  Gln Val Val Asn Thr  Tyr His Leu Asp Gly  Ile Asp Phe 
    1100                 1105                 1110             


Asp Asp  Glu Tyr Ala Glu Tyr  Gly Lys Asn Gly Thr  Pro Gln Pro 
    1115                 1120                 1125             


Asn Asn  Ser Ser Phe Ile Trp  Leu Leu Gln Ala Leu  Arg Asn Arg 
    1130                 1135                 1140             


Leu Gly  Asn Asp Lys Leu Ile  Thr Phe Tyr Asn Ile  Gly Pro Ala 
    1145                 1150                 1155             


Ala Ala  Asn Ser Ser Ala Asn  Pro Gln Met Ser Ser  Leu Ile Asp 
    1160                 1165                 1170             


Tyr Ala  Trp Asn Pro Tyr Tyr  Ser Thr Trp Asn Pro  Pro Gln Ile 
    1175                 1180                 1185             


Ala Gly  Met Pro Ala Ser Arg  Leu Gly Ala Ser Ala  Val Glu Val 
    1190                 1195                 1200             


Gly Val  Asn Gln Asn Leu Ala  Ala Gln Tyr Ala Lys  Arg Thr Lys 
    1205                 1210                 1215             


Ala Glu  Gln Tyr Gly Ile Tyr  Leu Met Tyr Asn Leu  Pro Gly Lys 
    1220                 1225                 1230             


Asp Ser  Ser Ala Tyr Ile Ser  Ala Ala Thr Gln Glu  Leu Tyr Gly 
    1235                 1240                 1245             


Arg Lys  Thr Asn Tyr Ser Pro  Thr Val Pro Thr Pro  
    1250                 1255                 1260 


<210>  16
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF3-EndoF1

<400>  16

Met Ala Thr Ala Leu Ala Gly Ser Asn Gly Val Cys Ile Ala Tyr Tyr 
1               5                   10                  15      


Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys Leu Lys Asp Ile Pro Asp 
            20                  25                  30          


Lys Val Asp Met Val Ile Leu Phe Gly Leu Lys Tyr Trp Ser Leu Gln 
        35                  40                  45              


Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly Met Met Gly Ser Phe Lys 
    50                  55                  60                  


Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg Ser Leu Gln Ser Arg Gly 
65                  70                  75                  80  


Ile Lys Val Leu Gln Asn Ile Asp Asp Asp Val Ser Trp Gln Ser Ser 
                85                  90                  95      


Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala Tyr Gly Asp Ala Ile Lys 
            100                 105                 110         


Ser Ile Val Ile Asp Lys Trp Lys Leu Asp Gly Ile Ser Leu Asp Ile 
        115                 120                 125             


Glu His Ser Gly Ala Lys Pro Asn Pro Ile Pro Thr Phe Pro Gly Tyr 
    130                 135                 140                 


Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser Gly Ser Met Ala Ala Thr 
145                 150                 155                 160 


Pro Ala Phe Leu Asn Val Ile Ser Glu Leu Thr Lys Tyr Phe Gly Thr 
                165                 170                 175     


Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile Ala Ser Gly Ile Asp Val 
            180                 185                 190         


Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe Arg Asn Asn Phe Asn Tyr 
        195                 200                 205             


Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val Ser Arg Thr Gln Leu Met 
    210                 215                 220                 


Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile Pro Ala Ser Lys Met Val 
225                 230                 235                 240 


Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn Gln Ala Asn Asp Val Glu 
                245                 250                 255     


Val Ala Lys Trp Thr Pro Thr Gln Gly Ala Lys Gly Gly Met Met Ile 
            260                 265                 270         


Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala Asn Ala Val Arg Asp Ala 
        275                 280                 285             


Val Lys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Thr Gly Thr Thr Lys 
                325                 330                 335     


Ala Asn Ile Lys Leu Phe Ser Phe Thr Glu Val Asn Asp Thr Asn Pro 
            340                 345                 350         


Leu Asn Asn Leu Asn Phe Thr Leu Lys Asn Ser Gly Lys Pro Leu Val 
        355                 360                 365             


Asp Met Val Val Leu Phe Ser Ala Asn Ile Asn Tyr Asp Ala Ala Asn 
    370                 375                 380                 


Asp Lys Val Phe Val Ser Asn Asn Pro Asn Val Gln His Leu Leu Thr 
385                 390                 395                 400 


Asn Arg Ala Lys Tyr Leu Lys Pro Leu Gln Asp Lys Gly Ile Lys Val 
                405                 410                 415     


Ile Leu Ser Ile Leu Gly Asn His Asp Arg Ser Gly Ile Ala Asn Leu 
            420                 425                 430         


Ser Thr Ala Arg Ala Lys Ala Phe Ala Gln Glu Leu Lys Asn Thr Cys 
        435                 440                 445             


Asp Leu Tyr Asn Leu Asp Gly Val Phe Phe Asp Asp Glu Tyr Ser Ala 
    450                 455                 460                 


Tyr Gln Thr Pro Pro Pro Ser Gly Phe Val Thr Pro Ser Asn Asn Ala 
465                 470                 475                 480 


Ala Ala Arg Leu Ala Tyr Glu Thr Lys Gln Ala Met Pro Asn Lys Leu 
                485                 490                 495     


Val Thr Val Tyr Val Tyr Ser Arg Thr Ser Ser Phe Pro Thr Ala Val 
            500                 505                 510         


Asp Gly Val Asn Ala Gly Ser Tyr Val Asp Tyr Ala Ile His Asp Tyr 
        515                 520                 525             


Gly Gly Ser Tyr Asp Leu Ala Thr Asn Tyr Pro Gly Leu Ala Lys Ser 
    530                 535                 540                 


Gly Met Val Met Ser Ser Gln Glu Phe Asn Gln Gly Arg Tyr Ala Thr 
545                 550                 555                 560 


Ala Gln Ala Leu Arg Asn Ile Val Thr Lys Gly Tyr Gly Gly His Met 
                565                 570                 575     


Ile Phe Ala Met Asp Pro Asn Arg Ser Asn Phe Thr Ser Gly Gln Leu 
            580                 585                 590         


Pro Ala Leu Lys Leu Ile Ala Lys Glu Leu Tyr Gly Asp Glu Leu Val 
        595                 600                 605             


Tyr Ser Asn Thr Pro Tyr Ser Lys Asp Trp 
    610                 615             


<210>  17
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF2-EndoF1

<400>  17

Met Ala Val Asn Leu Ser Asn Leu Ile Ala Tyr Lys Asn Ser Asp His 
1               5                   10                  15      


Gln Ile Ser Ala Gly Tyr Tyr Arg Thr Trp Arg Asp Ser Ala Thr Ala 
            20                  25                  30          


Ser Gly Asn Leu Pro Ser Met Arg Trp Leu Pro Asp Ser Leu Asp Met 
        35                  40                  45              


Val Met Val Phe Pro Asp Tyr Thr Pro Pro Glu Asn Ala Tyr Trp Asn 
    50                  55                  60                  


Thr Leu Lys Thr Asn Tyr Val Pro Tyr Leu His Lys Arg Gly Thr Lys 
65                  70                  75                  80  


Val Ile Ile Thr Leu Gly Asp Leu Asn Ser Ala Thr Thr Thr Gly Gly 
                85                  90                  95      


Gln Asp Ser Ile Gly Tyr Ser Ser Trp Ala Lys Gly Ile Tyr Asp Lys 
            100                 105                 110         


Trp Val Gly Glu Tyr Asn Leu Asp Gly Ile Asp Ile Asp Ile Glu Ser 
        115                 120                 125             


Ser Pro Ser Gly Ala Thr Leu Thr Lys Phe Val Ala Ala Thr Lys Ala 
    130                 135                 140                 


Leu Ser Lys Tyr Phe Gly Pro Lys Ser Gly Thr Gly Lys Thr Phe Val 
145                 150                 155                 160 


Tyr Asp Thr Asn Gln Asn Pro Thr Asn Phe Phe Ile Gln Thr Ala Pro 
                165                 170                 175     


Arg Tyr Asn Tyr Val Phe Leu Gln Ala Tyr Gly Arg Ser Thr Thr Asn 
            180                 185                 190         


Leu Thr Thr Val Ser Gly Leu Tyr Ala Pro Tyr Ile Ser Met Lys Gln 
        195                 200                 205             


Phe Leu Pro Gly Phe Ser Phe Tyr Glu Glu Asn Gly Tyr Pro Gly Asn 
    210                 215                 220                 


Tyr Trp Asn Asp Val Arg Tyr Pro Gln Asn Gly Thr Gly Arg Ala Tyr 
225                 230                 235                 240 


Asp Tyr Ala Arg Trp Gln Pro Ala Thr Gly Lys Lys Gly Gly Val Phe 
                245                 250                 255     


Ser Tyr Ala Ile Glu Arg Asp Ala Pro Leu Thr Ser Ser Asn Asp Asn 
            260                 265                 270         


Thr Leu Arg Ala Pro Asn Phe Arg Val Thr Lys Asp Leu Ile Lys Ile 
        275                 280                 285             


Met Asn Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Thr Gly Thr Thr Lys 
                325                 330                 335     


Ala Asn Ile Lys Leu Phe Ser Phe Thr Glu Val Asn Asp Thr Asn Pro 
            340                 345                 350         


Leu Asn Asn Leu Asn Phe Thr Leu Lys Asn Ser Gly Lys Pro Leu Val 
        355                 360                 365             


Asp Met Val Val Leu Phe Ser Ala Asn Ile Asn Tyr Asp Ala Ala Asn 
    370                 375                 380                 


Asp Lys Val Phe Val Ser Asn Asn Pro Asn Val Gln His Leu Leu Thr 
385                 390                 395                 400 


Asn Arg Ala Lys Tyr Leu Lys Pro Leu Gln Asp Lys Gly Ile Lys Val 
                405                 410                 415     


Ile Leu Ser Ile Leu Gly Asn His Asp Arg Ser Gly Ile Ala Asn Leu 
            420                 425                 430         


Ser Thr Ala Arg Ala Lys Ala Phe Ala Gln Glu Leu Lys Asn Thr Cys 
        435                 440                 445             


Asp Leu Tyr Asn Leu Asp Gly Val Phe Phe Asp Asp Glu Tyr Ser Ala 
    450                 455                 460                 


Tyr Gln Thr Pro Pro Pro Ser Gly Phe Val Thr Pro Ser Asn Asn Ala 
465                 470                 475                 480 


Ala Ala Arg Leu Ala Tyr Glu Thr Lys Gln Ala Met Pro Asn Lys Leu 
                485                 490                 495     


Val Thr Val Tyr Val Tyr Ser Arg Thr Ser Ser Phe Pro Thr Ala Val 
            500                 505                 510         


Asp Gly Val Asn Ala Gly Ser Tyr Val Asp Tyr Ala Ile His Asp Tyr 
        515                 520                 525             


Gly Gly Ser Tyr Asp Leu Ala Thr Asn Tyr Pro Gly Leu Ala Lys Ser 
    530                 535                 540                 


Gly Met Val Met Ser Ser Gln Glu Phe Asn Gln Gly Arg Tyr Ala Thr 
545                 550                 555                 560 


Ala Gln Ala Leu Arg Asn Ile Val Thr Lys Gly Tyr Gly Gly His Met 
                565                 570                 575     


Ile Phe Ala Met Asp Pro Asn Arg Ser Asn Phe Thr Ser Gly Gln Leu 
            580                 585                 590         


Pro Ala Leu Lys Leu Ile Ala Lys Glu Leu Tyr Gly Asp Glu Leu Val 
        595                 600                 605             


Tyr Ser Asn Thr Pro Tyr Ser Lys Asp Trp 
    610                 615             


<210>  18
<211>  1276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoS-EndoF1

<400>  18

Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys 
1               5                   10                  15      


Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val 
            20                  25                  30          


Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu 
        35                  40                  45              


Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His 
    50                  55                  60                  


Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser 
65                  70                  75                  80  


Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys 
                85                  90                  95      


Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys 
        115                 120                 125             


Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly 
    130                 135                 140                 


Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr 
145                 150                 155                 160 


Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val 
                165                 170                 175     


Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser 
            180                 185                 190         


Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser 
        195                 200                 205             


Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val 
    210                 215                 220                 


Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys 
225                 230                 235                 240 


Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val 
                245                 250                 255     


Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser 
            260                 265                 270         


Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys 
        275                 280                 285             


Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu 
    290                 295                 300                 


Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp 
305                 310                 315                 320 


Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala 
                325                 330                 335     


Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly 
            340                 345                 350         


Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys 
        355                 360                 365             


Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe 
    370                 375                 380                 


His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys 
385                 390                 395                 400 


Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala 
                405                 410                 415     


Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu 
            420                 425                 430         


Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser 
        435                 440                 445             


Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile 
    450                 455                 460                 


Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn 
465                 470                 475                 480 


Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys 
                485                 490                 495     


Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp 
        515                 520                 525             


Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu 
    530                 535                 540                 


Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu 
545                 550                 555                 560 


Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val 
                565                 570                 575     


Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly 
            580                 585                 590         


His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala 
        595                 600                 605             


Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr 
    610                 615                 620                 


Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln 
625                 630                 635                 640 


Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr 
                645                 650                 655     


Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp 
            660                 665                 670         


Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu 
        675                 680                 685             


Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala 
    690                 695                 700                 


Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val 
705                 710                 715                 720 


Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val 
                725                 730                 735     


Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn 
            740                 745                 750         


Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys 
        755                 760                 765             


Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg 
    770                 775                 780                 


Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile 
785                 790                 795                 800 


Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn 
                805                 810                 815     


Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala 
            820                 825                 830         


Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr 
        835                 840                 845             


Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser 
    850                 855                 860                 


Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn 
865                 870                 875                 880 


Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln 
                885                 890                 895     


Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys 
            900                 905                 910         


Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr 
        915                 920                 925             


Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg 
    930                 935                 940                 


Gln Leu Leu Lys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly 
                965                 970                 975     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Thr Gly Thr 
            980                 985                 990         


Thr Lys Ala Asn Ile Lys Leu Phe  Ser Phe Thr Glu Val  Asn Asp Thr 
        995                 1000                 1005             


Asn Pro  Leu Asn Asn Leu Asn  Phe Thr Leu Lys Asn  Ser Gly Lys 
    1010                 1015                 1020             


Pro Leu  Val Asp Met Val Val  Leu Phe Ser Ala Asn  Ile Asn Tyr 
    1025                 1030                 1035             


Asp Ala  Ala Asn Asp Lys Val  Phe Val Ser Asn Asn  Pro Asn Val 
    1040                 1045                 1050             


Gln His  Leu Leu Thr Asn Arg  Ala Lys Tyr Leu Lys  Pro Leu Gln 
    1055                 1060                 1065             


Asp Lys  Gly Ile Lys Val Ile  Leu Ser Ile Leu Gly  Asn His Asp 
    1070                 1075                 1080             


Arg Ser  Gly Ile Ala Asn Leu  Ser Thr Ala Arg Ala  Lys Ala Phe 
    1085                 1090                 1095             


Ala Gln  Glu Leu Lys Asn Thr  Cys Asp Leu Tyr Asn  Leu Asp Gly 
    1100                 1105                 1110             


Val Phe  Phe Asp Asp Glu Tyr  Ser Ala Tyr Gln Thr  Pro Pro Pro 
    1115                 1120                 1125             


Ser Gly  Phe Val Thr Pro Ser  Asn Asn Ala Ala Ala  Arg Leu Ala 
    1130                 1135                 1140             


Tyr Glu  Thr Lys Gln Ala Met  Pro Asn Lys Leu Val  Thr Val Tyr 
    1145                 1150                 1155             


Val Tyr  Ser Arg Thr Ser Ser  Phe Pro Thr Ala Val  Asp Gly Val 
    1160                 1165                 1170             


Asn Ala  Gly Ser Tyr Val Asp  Tyr Ala Ile His Asp  Tyr Gly Gly 
    1175                 1180                 1185             


Ser Tyr  Asp Leu Ala Thr Asn  Tyr Pro Gly Leu Ala  Lys Ser Gly 
    1190                 1195                 1200             


Met Val  Met Ser Ser Gln Glu  Phe Asn Gln Gly Arg  Tyr Ala Thr 
    1205                 1210                 1215             


Ala Gln  Ala Leu Arg Asn Ile  Val Thr Lys Gly Tyr  Gly Gly His 
    1220                 1225                 1230             


Met Ile  Phe Ala Met Asp Pro  Asn Arg Ser Asn Phe  Thr Ser Gly 
    1235                 1240                 1245             


Gln Leu  Pro Ala Leu Lys Leu  Ile Ala Lys Glu Leu  Tyr Gly Asp 
    1250                 1255                 1260             


Glu Leu  Val Tyr Ser Asn Thr  Pro Tyr Ser Lys Asp  Trp 
    1265                 1270                 1275     


<210>  19
<211>  600
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF3-EndoH

<400>  19

Met Ala Thr Ala Leu Ala Gly Ser Asn Gly Val Cys Ile Ala Tyr Tyr 
1               5                   10                  15      


Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys Leu Lys Asp Ile Pro Asp 
            20                  25                  30          


Lys Val Asp Met Val Ile Leu Phe Gly Leu Lys Tyr Trp Ser Leu Gln 
        35                  40                  45              


Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly Met Met Gly Ser Phe Lys 
    50                  55                  60                  


Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg Ser Leu Gln Ser Arg Gly 
65                  70                  75                  80  


Ile Lys Val Leu Gln Asn Ile Asp Asp Asp Val Ser Trp Gln Ser Ser 
                85                  90                  95      


Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala Tyr Gly Asp Ala Ile Lys 
            100                 105                 110         


Ser Ile Val Ile Asp Lys Trp Lys Leu Asp Gly Ile Ser Leu Asp Ile 
        115                 120                 125             


Glu His Ser Gly Ala Lys Pro Asn Pro Ile Pro Thr Phe Pro Gly Tyr 
    130                 135                 140                 


Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser Gly Ser Met Ala Ala Thr 
145                 150                 155                 160 


Pro Ala Phe Leu Asn Val Ile Ser Glu Leu Thr Lys Tyr Phe Gly Thr 
                165                 170                 175     


Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile Ala Ser Gly Ile Asp Val 
            180                 185                 190         


Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe Arg Asn Asn Phe Asn Tyr 
        195                 200                 205             


Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val Ser Arg Thr Gln Leu Met 
    210                 215                 220                 


Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile Pro Ala Ser Lys Met Val 
225                 230                 235                 240 


Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn Gln Ala Asn Asp Val Glu 
                245                 250                 255     


Val Ala Lys Trp Thr Pro Thr Gln Gly Ala Lys Gly Gly Met Met Ile 
            260                 265                 270         


Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala Asn Ala Val Arg Asp Ala 
        275                 280                 285             


Val Lys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Val Lys Gln 
                325                 330                 335     


Gly Pro Thr Ser Val Ala Tyr Val Glu Val Asn Asn Asn Ser Met Leu 
            340                 345                 350         


Asn Val Gly Lys Tyr Thr Leu Ala Asp Gly Gly Gly Asn Ala Phe Asp 
        355                 360                 365             


Val Ala Val Ile Phe Ala Ala Asn Ile Asn Tyr Asp Thr Gly Thr Lys 
    370                 375                 380                 


Thr Ala Tyr Leu His Phe Asn Glu Asn Val Gln Arg Val Leu Asp Asn 
385                 390                 395                 400 


Ala Val Thr Gln Ile Arg Pro Leu Gln Gln Gln Gly Ile Lys Val Leu 
                405                 410                 415     


Leu Ser Val Leu Gly Asn His Gln Gly Ala Gly Phe Ala Asn Phe Pro 
            420                 425                 430         


Ser Gln Gln Ala Ala Ser Ala Phe Ala Lys Gln Leu Ser Asp Ala Val 
        435                 440                 445             


Ala Lys Tyr Gly Leu Asp Gly Val Asp Phe Asp Asp Glu Tyr Ala Glu 
    450                 455                 460                 


Tyr Gly Asn Asn Gly Thr Ala Gln Pro Asn Asp Ser Ser Phe Val His 
465                 470                 475                 480 


Leu Val Thr Ala Leu Arg Ala Asn Met Pro Asp Lys Ile Ile Ser Leu 
                485                 490                 495     


Tyr Asn Ile Gly Pro Ala Ala Ser Arg Leu Ser Tyr Gly Gly Val Asp 
            500                 505                 510         


Val Ser Asp Lys Phe Asp Tyr Ala Trp Asn Pro Tyr Tyr Gly Thr Trp 
        515                 520                 525             


Gln Val Pro Gly Ile Ala Leu Pro Lys Ala Gln Leu Ser Pro Ala Ala 
    530                 535                 540                 


Val Glu Ile Gly Arg Thr Ser Arg Ser Thr Val Ala Asp Leu Ala Arg 
545                 550                 555                 560 


Arg Thr Val Asp Glu Gly Tyr Gly Val Tyr Leu Thr Tyr Asn Leu Asp 
                565                 570                 575     


Gly Gly Asp Arg Thr Ala Asp Val Ser Ala Phe Thr Arg Glu Leu Tyr 
            580                 585                 590         


Gly Ser Glu Ala Val Arg Thr Pro 
        595                 600 


<210>  20
<211>  600
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EndoF2-EndoH

<400>  20

Met Ala Val Asn Leu Ser Asn Leu Ile Ala Tyr Lys Asn Ser Asp His 
1               5                   10                  15      


Gln Ile Ser Ala Gly Tyr Tyr Arg Thr Trp Arg Asp Ser Ala Thr Ala 
            20                  25                  30          


Ser Gly Asn Leu Pro Ser Met Arg Trp Leu Pro Asp Ser Leu Asp Met 
        35                  40                  45              


Val Met Val Phe Pro Asp Tyr Thr Pro Pro Glu Asn Ala Tyr Trp Asn 
    50                  55                  60                  


Thr Leu Lys Thr Asn Tyr Val Pro Tyr Leu His Lys Arg Gly Thr Lys 
65                  70                  75                  80  


Val Ile Ile Thr Leu Gly Asp Leu Asn Ser Ala Thr Thr Thr Gly Gly 
                85                  90                  95      


Gln Asp Ser Ile Gly Tyr Ser Ser Trp Ala Lys Gly Ile Tyr Asp Lys 
            100                 105                 110         


Trp Val Gly Glu Tyr Asn Leu Asp Gly Ile Asp Ile Asp Ile Glu Ser 
        115                 120                 125             


Ser Pro Ser Gly Ala Thr Leu Thr Lys Phe Val Ala Ala Thr Lys Ala 
    130                 135                 140                 


Leu Ser Lys Tyr Phe Gly Pro Lys Ser Gly Thr Gly Lys Thr Phe Val 
145                 150                 155                 160 


Tyr Asp Thr Asn Gln Asn Pro Thr Asn Phe Phe Ile Gln Thr Ala Pro 
                165                 170                 175     


Arg Tyr Asn Tyr Val Phe Leu Gln Ala Tyr Gly Arg Ser Thr Thr Asn 
            180                 185                 190         


Leu Thr Thr Val Ser Gly Leu Tyr Ala Pro Tyr Ile Ser Met Lys Gln 
        195                 200                 205             


Phe Leu Pro Gly Phe Ser Phe Tyr Glu Glu Asn Gly Tyr Pro Gly Asn 
    210                 215                 220                 


Tyr Trp Asn Asp Val Arg Tyr Pro Gln Asn Gly Thr Gly Arg Ala Tyr 
225                 230                 235                 240 


Asp Tyr Ala Arg Trp Gln Pro Ala Thr Gly Lys Lys Gly Gly Val Phe 
                245                 250                 255     


Ser Tyr Ala Ile Glu Arg Asp Ala Pro Leu Thr Ser Ser Asn Asp Asn 
            260                 265                 270         


Thr Leu Arg Ala Pro Asn Phe Arg Val Thr Lys Asp Leu Ile Lys Ile 
        275                 280                 285             


Met Asn Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser His His His His His His Glu Phe Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Val Lys Gln 
                325                 330                 335     


Gly Pro Thr Ser Val Ala Tyr Val Glu Val Asn Asn Asn Ser Met Leu 
            340                 345                 350         


Asn Val Gly Lys Tyr Thr Leu Ala Asp Gly Gly Gly Asn Ala Phe Asp 
        355                 360                 365             


Val Ala Val Ile Phe Ala Ala Asn Ile Asn Tyr Asp Thr Gly Thr Lys 
    370                 375                 380                 


Thr Ala Tyr Leu His Phe Asn Glu Asn Val Gln Arg Val Leu Asp Asn 
385                 390                 395                 400 


Ala Val Thr Gln Ile Arg Pro Leu Gln Gln Gln Gly Ile Lys Val Leu 
                405                 410                 415     


Leu Ser Val Leu Gly Asn His Gln Gly Ala Gly Phe Ala Asn Phe Pro 
            420                 425                 430         


Ser Gln Gln Ala Ala Ser Ala Phe Ala Lys Gln Leu Ser Asp Ala Val 
        435                 440                 445             


Ala Lys Tyr Gly Leu Asp Gly Val Asp Phe Asp Asp Glu Tyr Ala Glu 
    450                 455                 460                 


Tyr Gly Asn Asn Gly Thr Ala Gln Pro Asn Asp Ser Ser Phe Val His 
465                 470                 475                 480 


Leu Val Thr Ala Leu Arg Ala Asn Met Pro Asp Lys Ile Ile Ser Leu 
                485                 490                 495     


Tyr Asn Ile Gly Pro Ala Ala Ser Arg Leu Ser Tyr Gly Gly Val Asp 
            500                 505                 510         


Val Ser Asp Lys Phe Asp Tyr Ala Trp Asn Pro Tyr Tyr Gly Thr Trp 
        515                 520                 525             


Gln Val Pro Gly Ile Ala Leu Pro Lys Ala Gln Leu Ser Pro Ala Ala 
    530                 535                 540                 


Val Glu Ile Gly Arg Thr Ser Arg Ser Thr Val Ala Asp Leu Ala Arg 
545                 550                 555                 560 


Arg Thr Val Asp Glu Gly Tyr Gly Val Tyr Leu Thr Tyr Asn Leu Asp 
                565                 570                 575     


Gly Gly Asp Arg Thr Ala Asp Val Ser Ala Phe Thr Arg Glu Leu Tyr 
            580                 585                 590         


Gly Ser Glu Ala Val Arg Thr Pro 
        595                 600 


<210>  21
<211>  1240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His6-EndoS-EndoH

<400>  21

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Ser Ile Asp Ser Leu His Tyr Leu Ser Glu 
            20                  25                  30          


Asn Ser Lys Lys Glu Phe Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu 
        35                  40                  45              


Ser Gln Lys Val Lys Glu Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys 
    50                  55                  60                  


Gln Ala Gln Glu Leu Ala Lys Met Lys Ile Pro Glu Lys Ile Pro Met 
65                  70                  75                  80  


Lys Pro Leu His Gly Pro Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His 
                85                  90                  95      


Asp Lys Thr Ser Asp Pro Thr Glu Lys Asp Lys Val Asn Ser Met Gly 
            100                 105                 110         


Glu Leu Pro Lys Glu Val Asp Leu Ala Phe Ile Phe His Asp Trp Thr 
        115                 120                 125             


Lys Asp Tyr Ser Leu Phe Trp Lys Glu Leu Ala Thr Lys His Val Pro 
    130                 135                 140                 


Lys Leu Asn Lys Gln Gly Thr Arg Val Ile Arg Thr Ile Pro Trp Arg 
145                 150                 155                 160 


Phe Leu Ala Gly Gly Asp Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys 
                165                 170                 175     


Tyr Pro Asn Thr Pro Glu Gly Asn Lys Ala Leu Ala Lys Ala Ile Val 
            180                 185                 190         


Asp Glu Tyr Val Tyr Lys Tyr Asn Leu Asp Gly Leu Asp Val Asp Val 
        195                 200                 205             


Glu His Asp Ser Ile Pro Lys Val Asp Lys Lys Glu Asp Thr Ala Gly 
    210                 215                 220                 


Val Glu Arg Ser Ile Gln Val Phe Glu Glu Ile Gly Lys Leu Ile Gly 
225                 230                 235                 240 


Pro Lys Gly Val Asp Lys Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr 
                245                 250                 255     


Met Ala Asp Lys Asn Pro Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn 
            260                 265                 270         


Leu Leu Leu Val Gln Val Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp 
        275                 280                 285             


Glu Pro Val Ser Asn Arg Pro Glu Lys Thr Met Glu Glu Arg Trp Gln 
    290                 295                 300                 


Gly Tyr Ser Lys Tyr Ile Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser 
305                 310                 315                 320 


Phe Tyr Glu Glu Asn Ala Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn 
                325                 330                 335     


Ser Arg Lys Asp Glu Asp Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr 
            340                 345                 350         


Gly Thr Arg Ala Glu Arg Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly 
        355                 360                 365             


Val Lys Gly Gly Ile Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala 
    370                 375                 380                 


His Gln Pro Lys Lys Tyr Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr 
385                 390                 395                 400 


Asp Asn Ile Phe His Ser Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr 
                405                 410                 415     


Val Met Leu Lys Asp Lys Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe 
            420                 425                 430         


Pro Asp Lys Ala Leu Arg Glu Ala Val Met Ala Gln Val Gly Thr Arg 
        435                 440                 445             


Lys Gly Asp Leu Glu Arg Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro 
    450                 455                 460                 


Ala Ile Gln Ser Leu Glu Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln 
465                 470                 475                 480 


Leu Asp Leu Ile Gly Leu Ser Arg Ile Thr Lys Leu Asp Arg Ser Val 
                485                 490                 495     


Leu Pro Ala Asn Met Lys Pro Gly Lys Asp Thr Leu Glu Thr Val Leu 
            500                 505                 510         


Glu Thr Tyr Lys Lys Asp Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro 
        515                 520                 525             


Val Ser Leu Lys Val Ser Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu 
    530                 535                 540                 


Ser Gly Phe Asp Arg Glu Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu 
545                 550                 555                 560 


Thr Ser Leu Glu Lys Val Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala 
                565                 570                 575     


Pro Gly Thr Glu Asn Arg Gln Ile Phe Asp Thr Met Leu Ser Thr Ile 
            580                 585                 590         


Ser Asn His Val Gly Ser Asn Glu Gln Thr Val Lys Phe Asp Lys Gln 
        595                 600                 605             


Lys Pro Thr Gly His Tyr Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg 
    610                 615                 620                 


Leu Pro Val Ala Asn Glu Lys Val Asp Leu Gln Ser Gln Leu Leu Phe 
625                 630                 635                 640 


Gly Thr Val Thr Asn Gln Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr 
                645                 650                 655     


Lys Ala Tyr Gln Asn His Lys Ile Ala Gly Arg Ser Phe Val Asp Ser 
            660                 665                 670         


Asn Tyr His Tyr Asn Asn Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val 
        675                 680                 685             


Lys Val Thr Asp Ser Thr Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala 
    690                 695                 700                 


Thr Asp Lys Glu Glu Thr Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp 
705                 710                 715                 720 


Lys Thr Lys Ala Val His Thr Ala Lys Val Ile Val Gly Asp Glu Lys 
                725                 730                 735     


Thr Met Met Val Asn Leu Ala Glu Gly Ala Thr Val Ile Gly Gly Ser 
            740                 745                 750         


Ala Asp Pro Val Asn Ala Arg Lys Val Phe Asp Gly Gln Leu Gly Ser 
        755                 760                 765             


Glu Thr Asp Asn Ile Ser Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile 
    770                 775                 780                 


Phe Lys Leu Lys Glu Asp Gly Leu Ile Lys His Trp Arg Phe Phe Asn 
785                 790                 795                 800 


Asp Ser Ala Arg Asn Pro Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala 
                805                 810                 815     


Ser Leu Gln Ile Phe Asn Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu 
            820                 825                 830         


Glu Asn Pro Asn Lys Phe Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp 
        835                 840                 845             


Thr Tyr Ser Ala Gln Gly Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu 
    850                 855                 860                 


Asn Asn Ile Thr Ser Lys Tyr Trp Arg Val Val Phe Asp Thr Lys Gly 
865                 870                 875                 880 


Asp Arg Tyr Ser Ser Pro Val Val Pro Glu Leu Gln Ile Leu Gly Tyr 
                885                 890                 895     


Pro Leu Pro Asn Ala Asp Thr Ile Met Lys Thr Val Thr Thr Ala Lys 
            900                 905                 910         


Glu Leu Ser Gln Gln Lys Asp Lys Phe Ser Gln Lys Met Leu Asp Glu 
        915                 920                 925             


Leu Lys Ile Lys Glu Met Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile 
    930                 935                 940                 


Phe Asp Val Thr Ala Ile Asn Ala Asn Ala Gly Val Leu Lys Asp Cys 
945                 950                 955                 960 


Ile Glu Lys Arg Gln Leu Leu Lys Lys Ala Pro Ala Pro Val Lys Gln 
                965                 970                 975     


Gly Pro Thr Ser Val Ala Tyr Val Glu Val Asn Asn Asn Ser Met Leu 
            980                 985                 990         


Asn Val Gly Lys Tyr Thr Leu Ala  Asp Gly Gly Gly Asn  Ala Phe Asp 
        995                 1000                 1005             


Val Ala  Val Ile Phe Ala Ala  Asn Ile Asn Tyr Asp  Thr Gly Thr 
    1010                 1015                 1020             


Lys Thr  Ala Tyr Leu His Phe  Asn Glu Asn Val Gln  Arg Val Leu 
    1025                 1030                 1035             


Asp Asn  Ala Val Thr Gln Ile  Arg Pro Leu Gln Gln  Gln Gly Ile 
    1040                 1045                 1050             


Lys Val  Leu Leu Ser Val Leu  Gly Asn His Gln Gly  Ala Gly Phe 
    1055                 1060                 1065             


Ala Asn  Phe Pro Ser Gln Gln  Ala Ala Ser Ala Phe  Ala Lys Gln 
    1070                 1075                 1080             


Leu Ser  Asp Ala Val Ala Lys  Tyr Gly Leu Asp Gly  Val Asp Phe 
    1085                 1090                 1095             


Asp Asp  Glu Tyr Ala Glu Tyr  Gly Asn Asn Gly Thr  Ala Gln Pro 
    1100                 1105                 1110             


Asn Asp  Ser Ser Phe Val His  Leu Val Thr Ala Leu  Arg Ala Asn 
    1115                 1120                 1125             


Met Pro  Asp Lys Ile Ile Ser  Leu Tyr Asn Ile Gly  Pro Ala Ala 
    1130                 1135                 1140             


Ser Arg  Leu Ser Tyr Gly Gly  Val Asp Val Ser Asp  Lys Phe Asp 
    1145                 1150                 1155             


Tyr Ala  Trp Asn Pro Tyr Tyr  Gly Thr Trp Gln Val  Pro Gly Ile 
    1160                 1165                 1170             


Ala Leu  Pro Lys Ala Gln Leu  Ser Pro Ala Ala Val  Glu Ile Gly 
    1175                 1180                 1185             


Arg Thr  Ser Arg Ser Thr Val  Ala Asp Leu Ala Arg  Arg Thr Val 
    1190                 1195                 1200             


Asp Glu  Gly Tyr Gly Val Tyr  Leu Thr Tyr Asn Leu  Asp Gly Gly 
    1205                 1210                 1215             


Asp Arg  Thr Ala Asp Val Ser  Ala Phe Thr Arg Glu  Leu Tyr Gly 
    1220                 1225                 1230             


Ser Glu  Ala Val Arg Thr Pro  
    1235                 1240 


<210>  22
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoF3-EfEndo18A

<400>  22
atggctacag cgctggctgg ttctaacggg gtctgcatcg cgtattacat caccgatggg       60

cgtaatccga cgttcaaatt gaaagacatc ccggataaag tagacatggt aattcttttt      120

ggtcttaagt attggtcatt gcaggataca accaaattgc cagggggtac tggtatgatg      180

ggttcgttta aatcctacaa ggacctggac acccagattc gtagtcttca aagccgtgga      240

atcaaagtgt tgcagaacat tgacgacgac gtctcatggc agtcctcgaa gccgggtggg      300

ttcgcttccg ccgctgctta cggggatgct attaagagta tcgtaattga taagtggaag      360

ctggacggga ttagcttgga tattgagcat tcgggggcta aacccaaccc tatcccaact      420

tttcctggat atgccgcgac aggatataat ggctggtatt caggatctat ggcagccacg      480

cctgcctttc ttaatgttat ctcagagctt actaaatact ttggtacaac ggcaccgaat      540

aataagcaac ttcagattgc ttcgggtatt gacgtatatg cctggaataa aatcatggag      600

aactttcgta ataacttcaa ctacatccaa ttacagtcat acggagctaa tgtctctcgt      660

actcaactta tgatgaatta cgcaacggga actaataaaa ttcccgcctc taaaatggtt      720

ttcggcgcct acgcagaggg tggcactaac caggcaaatg acgtggaggt cgccaagtgg      780

acacctacgc agggcgcaaa gggcggtatg atgatctata cttacaattc gaacgtgagc      840

tatgcaaatg cggttcgcga cgcagtgaaa aatggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgct tcaaccgtaa cccctaaaac ggttatgtac     1020

gtagaagtaa ataaccacga tttcaacaat gtcgggaaat acactcttgc cggtactaat     1080

cagccggcgt tcgatatggg tattattttt gccgccaaca tcaattatga caccgtcaat     1140

aagaaaccat acctgtactt gaacgagcgc gtacagcaaa cactgaatga agcggagacg     1200

cagatccgtc cggtccaggc acgtggaacg aaggttttgc tttccatctt gggtaatcac     1260

gaaggcgcag gatttgccaa ttttcctacg tatgagtcgg cggacgcttt cgccgcgcaa     1320

cttgagcagg ttgtcaatac gtaccattta gacgggattg atttcgatga tgagtacgcc     1380

gagtacggaa aaaacgggac ccctcagccg aacaactcat ccttcatctg gttactgcaa     1440

gctcttcgca accgtctggg aaatgataaa cttatcactt tctacaacat tggcccggca     1500

gccgctaaca gcagcgcaaa ccctcaaatg tcatctttga ttgactatgc ctggaatccc     1560

tattattcga catggaaccc cccacaaatt gcaggtatgc ctgcctcccg cctgggggct     1620

tctgcggttg aagtgggcgt taaccagaat cttgcagcac agtatgccaa gcgtactaag     1680

gctgagcagt atggaatcta tctgatgtac aatctgccag gaaaagattc tagcgcttat     1740

atctcagcag cgactcagga gctgtatggg cgcaagacga actatagccc cacggtcccg     1800

actccgtgat aa                                                         1812


<210>  23
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoF2-EfEndo18A

<400>  23
atggcggtaa accttagtaa tcttatcgct tataaaaata gtgaccatca gatcagtgcg       60

ggatattacc gtacatggcg tgacagcgcc acagccagtg gtaatcttcc tagtatgcgt      120

tggttgccag actcattgga catggtaatg gtattcccag actatactcc tccggaaaat      180

gcgtattgga acacactgaa gactaactac gtaccatacc tgcataagcg tggcacgaaa      240

gttattatca cattggggga ccttaactct gcaacgacca cgggagggca agattctatt      300

gggtattcat cgtgggccaa aggaatctat gataaatggg tgggcgagta taatcttgat      360

ggaatcgata ttgacatcga atcgtcaccg tccggtgcga ccttaacgaa gtttgttgcg      420

gcaacaaaag cgttgtcaaa gtattttgga ccaaagagtg ggacaggcaa gacctttgta      480

tacgatacca atcagaatcc gactaatttc tttatccaaa ctgccccacg ctacaactac      540

gtatttcttc aagcatacgg gcgctcgacc actaatctga cgacggtctc tggattatac      600

gccccctata tttcaatgaa acaatttctg cccggcttct ctttttacga agaaaacggt      660

tacccaggta attattggaa tgatgtgcgt tacccccaga acggtacagg ccgtgcctac      720

gactacgcgc gctggcagcc cgccacggga aaaaaaggag gggtgttcag ttatgccatc      780

gagcgcgacg cccctcttac atcgtcaaac gacaataccc tgcgtgcgcc taactttcgt      840

gtaacgaagg acttaatcaa aattatgaat cctggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgct tcaaccgtaa cccctaaaac ggttatgtac     1020

gtagaagtaa ataaccacga tttcaacaat gtcgggaaat acactcttgc cggtactaat     1080

cagccggcgt tcgatatggg tattattttt gccgccaaca tcaattatga caccgtcaat     1140

aagaaaccat acctgtactt gaacgagcgc gtacagcaaa cactgaatga agcggagacg     1200

cagatccgtc cggtccaggc acgtggaacg aaggttttgc tttccatctt gggtaatcac     1260

gaaggcgcag gatttgccaa ttttcctacg tatgagtcgg cggacgcttt cgccgcgcaa     1320

cttgagcagg ttgtcaatac gtaccattta gacgggattg atttcgatga tgagtacgcc     1380

gagtacggaa aaaacgggac ccctcagccg aacaactcat ccttcatctg gttactgcaa     1440

gctcttcgca accgtctggg aaatgataaa cttatcactt tctacaacat tggcccggca     1500

gccgctaaca gcagcgcaaa ccctcaaatg tcatctttga ttgactatgc ctggaatccc     1560

tattattcga catggaaccc cccacaaatt gcaggtatgc ctgcctcccg cctgggggct     1620

tctgcggttg aagtgggcgt taaccagaat cttgcagcac agtatgccaa gcgtactaag     1680

gctgagcagt atggaatcta tctgatgtac aatctgccag gaaaagattc tagcgcttat     1740

atctcagcag cgactcagga gctgtatggg cgcaagacga actatagccc cacggtcccg     1800

actccgtgat aa                                                         1812


<210>  24
<211>  3786
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoS-EfEndo18A

<400>  24
atgccgtcaa tcgattcgct gcattatctg agcgaaaact ctaaaaaaga atttaaagaa       60

gaactgagca aagcgggcca ggaatctcaa aaagttaaag aaatcctggc aaaagctcag      120

caagccgata aacaggcaca agaactggct aaaatgaaaa ttccggaaaa aatcccgatg      180

aaaccgctgc atggtccgct gtacggcggt tatttccgta cctggcacga taaaacgtca      240

gacccgaccg aaaaagacaa agtcaactcg atgggcgaac tgccgaaaga agtggatctg      300

gcttttattt tccatgattg gaccaaagac tactctctgt tttggaaaga actggcaacg      360

aaacacgttc cgaaactgaa caaacagggt acgcgtgtca ttcgtaccat tccgtggcgc      420

ttcctggctg gcggtgataa ttcaggcatc gcggaagaca cctcgaaata tccgaacacg      480

ccggaaggta ataaagcgct ggccaaagca atcgtcgatg aatacgtgta caaatacaat      540

ctggacggcc tggatgtgga cgttgaacat gattcaattc cgaaagtgga taaaaaagaa      600

gacaccgccg gcgtggaacg ttcgatccag gtttttgaag aaattggtaa actgatcggc      660

ccgaaaggtg ttgataaaag ccgtctgttc atcatggatt ctacctatat ggccgacaaa      720

aatccgctga ttgaacgcgg tgcaccgtac atcaacctgc tgctggtcca ggtgtatggc      780

agccaaggtg aaaaaggcgg ttgggaaccg gtgtctaacc gtccggaaaa aaccatggaa      840

gaacgctggc agggctactc aaaatatatt cgtccggaac aatacatgat cggcttttcg      900

ttctatgaag aaaacgcgca ggaaggtaat ctgtggtacg atattaatag tcgcaaagat      960

gaagacaaag ccaacggcat taataccgat atcacgggta cccgtgcgga acgctatgcc     1020

cgttggcagc cgaaaaccgg cggtgttaaa ggcggtattt ttagctacgc gatcgatcgt     1080

gacggtgtcg cccatcagcc gaaaaaatac gcaaaacaaa aagagttcaa agatgctacc     1140

gacaacatct tccacagcga ttacagtgtc tccaaagcgc tgaaaaccgt gatgctgaaa     1200

gataaatctt acgatctgat cgacgaaaaa gattttccgg acaaagcgct gcgcgaagcc     1260

gttatggcac aggtcggcac ccgcaaaggt gacctggaac gttttaatgg cacgctgcgc     1320

ctggataacc cggccattca gagcctggaa ggtctgaata aattcaaaaa actggcacaa     1380

ctggacctga ttggcctgag ccgtatcacc aaactggatc gctctgtgct gccggccaac     1440

atgaaaccgg gtaaagacac gctggaaacc gttctggaaa cctacaaaaa agataacaaa     1500

gaagaaccgg caacgatccc gccggtgtct ctgaaagttt ccggcctgac cggtctgaaa     1560

gaactggatc tgagcggctt tgaccgtgaa acgctggcag gtctggatgc ggccacgctg     1620

accagtctgg aaaaagttga tatttccggc aataaactgg acctggcgcc gggtaccgaa     1680

aaccgccaga tttttgatac gatgctgagt accatctcca accatgttgg cagcaatgaa     1740

cagaccgtca aattcgacaa acaaaaaccg acgggccact acccggatac gtatggtaaa     1800

accagcctgc gtctgccggt cgccaacgaa aaagtggatc tgcagtctca actgctgttt     1860

ggcacggtta ccaatcaggg taccctgatt aacagcgaag cagattacaa ggcttaccaa     1920

aaccataaaa tcgcgggtcg ctcatttgtg gattcgaact accactacaa caacttcaaa     1980

gttagttacg aaaactacac cgttaaagtc acggattcca ccctgggcac cacgaccgat     2040

aaaacgctgg ccaccgacaa agaagaaacc tacaaagtcg atttctttag cccggcagac     2100

aaaacgaaag cggtgcatac cgccaaagtg attgttggcg atgaaaaaac catgatggtg     2160

aacctggctg aaggtgcgac ggttatcggc ggttccgcag acccggttaa cgctcgcaaa     2220

gtctttgatg gccagctggg tagtgaaacc gataatattt ccctgggttg ggactcaaaa     2280

cagtcgatta tcttcaaact gaaagaagac ggcctgatca aacactggcg tttctttaac     2340

gatagtgccc gcaatccgga aacgaccaac aaaccgattc aggaagcatc cctgcaaatc     2400

ttcaacatca aagattacaa cctggacaat ctgctggaaa acccgaataa attcgatgac     2460

gaaaaatact ggatcacggt ggatacctat agcgcgcagg gcgaacgtgc tacggcgttt     2520

agtaacaccc tgaacaatat tacgtccaaa tactggcgtg tggttttcga taccaaaggt     2580

gaccgctata gctctccggt cgtgccggaa ctgcagattc tgggctatcc gctgccgaat     2640

gctgatacga tcatgaaaac cgtgacgacc gcgaaagaac tgtcacagca aaaagataaa     2700

ttctcgcaga aaatgctgga cgaactgaaa attaaagaaa tggctctgga aaccagcctg     2760

aacagtaaaa ttttcgatgt tacggcgatc aatgctaacg ctggtgtgct gaaagactgt     2820

attgaaaaac gccaactgct gaaaaaaggc ggcggcggct ctggcggcgg cggctctggc     2880

ggcggcggct ctcaccacca ccaccaccac gaattcggcg gcggcggctc tggcggcggc     2940

ggctctggcg gcggcggctc tgcttcaacc gtaaccccta aaacggttat gtacgtagaa     3000

gtaaataacc acgatttcaa caatgtcggg aaatacactc ttgccggtac taatcagccg     3060

gcgttcgata tgggtattat ttttgccgcc aacatcaatt atgacaccgt caataagaaa     3120

ccatacctgt acttgaacga gcgcgtacag caaacactga atgaagcgga gacgcagatc     3180

cgtccggtcc aggcacgtgg aacgaaggtt ttgctttcca tcttgggtaa tcacgaaggc     3240

gcaggatttg ccaattttcc tacgtatgag tcggcggacg ctttcgccgc gcaacttgag     3300

caggttgtca atacgtacca tttagacggg attgatttcg atgatgagta cgccgagtac     3360

ggaaaaaacg ggacccctca gccgaacaac tcatccttca tctggttact gcaagctctt     3420

cgcaaccgtc tgggaaatga taaacttatc actttctaca acattggccc ggcagccgct     3480

aacagcagcg caaaccctca aatgtcatct ttgattgact atgcctggaa tccctattat     3540

tcgacatgga accccccaca aattgcaggt atgcctgcct cccgcctggg ggcttctgcg     3600

gttgaagtgg gcgttaacca gaatcttgca gcacagtatg ccaagcgtac taaggctgag     3660

cagtatggaa tctatctgat gtacaatctg ccaggaaaag attctagcgc ttatatctca     3720

gcagcgactc aggagctgta tgggcgcaag acgaactata gccccacggt cccgactccg     3780

tgataa                                                                3786


<210>  25
<211>  1860
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoF3-EndoF1

<400>  25
atggctacag cgctggctgg ttctaacggg gtctgcatcg cgtattacat caccgatggg       60

cgtaatccga cgttcaaatt gaaagacatc ccggataaag tagacatggt aattcttttt      120

ggtcttaagt attggtcatt gcaggataca accaaattgc cagggggtac tggtatgatg      180

ggttcgttta aatcctacaa ggacctggac acccagattc gtagtcttca aagccgtgga      240

atcaaagtgt tgcagaacat tgacgacgac gtctcatggc agtcctcgaa gccgggtggg      300

ttcgcttccg ccgctgctta cggggatgct attaagagta tcgtaattga taagtggaag      360

ctggacggga ttagcttgga tattgagcat tcgggggcta aacccaaccc tatcccaact      420

tttcctggat atgccgcgac aggatataat ggctggtatt caggatctat ggcagccacg      480

cctgcctttc ttaatgttat ctcagagctt actaaatact ttggtacaac ggcaccgaat      540

aataagcaac ttcagattgc ttcgggtatt gacgtatatg cctggaataa aatcatggag      600

aactttcgta ataacttcaa ctacatccaa ttacagtcat acggagctaa tgtctctcgt      660

actcaactta tgatgaatta cgcaacggga actaataaaa ttcccgcctc taaaatggtt      720

ttcggcgcct acgcagaggg tggcactaac caggcaaatg acgtggaggt cgccaagtgg      780

acacctacgc agggcgcaaa gggcggtatg atgatctata cttacaattc gaacgtgagc      840

tatgcaaatg cggttcgcga cgcagtgaaa aatggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgcg gtaaccggga caacgaaggc taacatcaaa     1020

ctttttagtt ttacagaggt aaacgacact aatccgttga acaatctgaa ctttacctta     1080

aaaaactcgg gaaaaccctt agtagatatg gtagtgttat tttccgcgaa cattaactat     1140

gacgcggcca acgataaggt cttcgtatcg aataatccga acgtacagca tcttttgacc     1200

aatcgtgcga agtaccttaa gccgttacaa gacaagggga tcaaggtgat tttgtcaatc     1260

ttagggaacc atgatcgctc cgggatcgcc aatttgagta cggctcgtgc gaaggcattt     1320

gctcaggaac tgaagaatac ttgcgatttg tataatttag acggggtatt ctttgatgat     1380

gagtactctg cttaccaaac gccaccgccg agcggcttcg tgacacccag taataacgcc     1440

gcagctcgcc ttgcttatga aacaaagcag gctatgccaa acaagctggt cacggtgtac     1500

gtctattccc gcacttcgag ttttcccaca gcggtagacg gggtcaacgc cgggtcctac     1560

gtagactatg cgattcatga ctacggtggc tcatacgact tggctactaa ttatccgggg     1620

ttggctaagt ctgggatggt gatgtctagt caggagttta accagggccg ttacgcgact     1680

gcacaagcat tgcgcaacat tgtgaccaag ggctatggag gccacatgat ctttgccatg     1740

gaccccaatc gttctaattt cacgtcaggg caactgcccg cactgaagct gattgccaag     1800

gagctttacg gggatgagct tgtgtacagc aacactcctt acagtaagga ttggtgataa     1860


<210>  26
<211>  1860
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein EndoF2-EndoF1

<400>  26
atggcggtaa accttagtaa tcttatcgct tataaaaata gtgaccatca gatcagtgcg       60

ggatattacc gtacatggcg tgacagcgcc acagccagtg gtaatcttcc tagtatgcgt      120

tggttgccag actcattgga catggtaatg gtattcccag actatactcc tccggaaaat      180

gcgtattgga acacactgaa gactaactac gtaccatacc tgcataagcg tggcacgaaa      240

gttattatca cattggggga ccttaactct gcaacgacca cgggagggca agattctatt      300

gggtattcat cgtgggccaa aggaatctat gataaatggg tgggcgagta taatcttgat      360

ggaatcgata ttgacatcga atcgtcaccg tccggtgcga ccttaacgaa gtttgttgcg      420

gcaacaaaag cgttgtcaaa gtattttgga ccaaagagtg ggacaggcaa gacctttgta      480

tacgatacca atcagaatcc gactaatttc tttatccaaa ctgccccacg ctacaactac      540

gtatttcttc aagcatacgg gcgctcgacc actaatctga cgacggtctc tggattatac      600

gccccctata tttcaatgaa acaatttctg cccggcttct ctttttacga agaaaacggt      660

tacccaggta attattggaa tgatgtgcgt tacccccaga acggtacagg ccgtgcctac      720

gactacgcgc gctggcagcc cgccacggga aaaaaaggag gggtgttcag ttatgccatc      780

gagcgcgacg cccctcttac atcgtcaaac gacaataccc tgcgtgcgcc taactttcgt      840

gtaacgaagg acttaatcaa aattatgaat cctggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgcg gtaaccggga caacgaaggc taacatcaaa     1020

ctttttagtt ttacagaggt aaacgacact aatccgttga acaatctgaa ctttacctta     1080

aaaaactcgg gaaaaccctt agtagatatg gtagtgttat tttccgcgaa cattaactat     1140

gacgcggcca acgataaggt cttcgtatcg aataatccga acgtacagca tcttttgacc     1200

aatcgtgcga agtaccttaa gccgttacaa gacaagggga tcaaggtgat tttgtcaatc     1260

ttagggaacc atgatcgctc cgggatcgcc aatttgagta cggctcgtgc gaaggcattt     1320

gctcaggaac tgaagaatac ttgcgatttg tataatttag acggggtatt ctttgatgat     1380

gagtactctg cttaccaaac gccaccgccg agcggcttcg tgacacccag taataacgcc     1440

gcagctcgcc ttgcttatga aacaaagcag gctatgccaa acaagctggt cacggtgtac     1500

gtctattccc gcacttcgag ttttcccaca gcggtagacg gggtcaacgc cgggtcctac     1560

gtagactatg cgattcatga ctacggtggc tcatacgact tggctactaa ttatccgggg     1620

ttggctaagt ctgggatggt gatgtctagt caggagttta accagggccg ttacgcgact     1680

gcacaagcat tgcgcaacat tgtgaccaag ggctatggag gccacatgat ctttgccatg     1740

gaccccaatc gttctaattt cacgtcaggg caactgcccg cactgaagct gattgccaag     1800

gagctttacg gggatgagct tgtgtacagc aacactcctt acagtaagga ttggtgataa     1860


<210>  27
<211>  3834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoS-EndoF1

<400>  27
atgccgtcaa tcgattcgct gcattatctg agcgaaaact ctaaaaaaga atttaaagaa       60

gaactgagca aagcgggcca ggaatctcaa aaagttaaag aaatcctggc aaaagctcag      120

caagccgata aacaggcaca agaactggct aaaatgaaaa ttccggaaaa aatcccgatg      180

aaaccgctgc atggtccgct gtacggcggt tatttccgta cctggcacga taaaacgtca      240

gacccgaccg aaaaagacaa agtcaactcg atgggcgaac tgccgaaaga agtggatctg      300

gcttttattt tccatgattg gaccaaagac tactctctgt tttggaaaga actggcaacg      360

aaacacgttc cgaaactgaa caaacagggt acgcgtgtca ttcgtaccat tccgtggcgc      420

ttcctggctg gcggtgataa ttcaggcatc gcggaagaca cctcgaaata tccgaacacg      480

ccggaaggta ataaagcgct ggccaaagca atcgtcgatg aatacgtgta caaatacaat      540

ctggacggcc tggatgtgga cgttgaacat gattcaattc cgaaagtgga taaaaaagaa      600

gacaccgccg gcgtggaacg ttcgatccag gtttttgaag aaattggtaa actgatcggc      660

ccgaaaggtg ttgataaaag ccgtctgttc atcatggatt ctacctatat ggccgacaaa      720

aatccgctga ttgaacgcgg tgcaccgtac atcaacctgc tgctggtcca ggtgtatggc      780

agccaaggtg aaaaaggcgg ttgggaaccg gtgtctaacc gtccggaaaa aaccatggaa      840

gaacgctggc agggctactc aaaatatatt cgtccggaac aatacatgat cggcttttcg      900

ttctatgaag aaaacgcgca ggaaggtaat ctgtggtacg atattaatag tcgcaaagat      960

gaagacaaag ccaacggcat taataccgat atcacgggta cccgtgcgga acgctatgcc     1020

cgttggcagc cgaaaaccgg cggtgttaaa ggcggtattt ttagctacgc gatcgatcgt     1080

gacggtgtcg cccatcagcc gaaaaaatac gcaaaacaaa aagagttcaa agatgctacc     1140

gacaacatct tccacagcga ttacagtgtc tccaaagcgc tgaaaaccgt gatgctgaaa     1200

gataaatctt acgatctgat cgacgaaaaa gattttccgg acaaagcgct gcgcgaagcc     1260

gttatggcac aggtcggcac ccgcaaaggt gacctggaac gttttaatgg cacgctgcgc     1320

ctggataacc cggccattca gagcctggaa ggtctgaata aattcaaaaa actggcacaa     1380

ctggacctga ttggcctgag ccgtatcacc aaactggatc gctctgtgct gccggccaac     1440

atgaaaccgg gtaaagacac gctggaaacc gttctggaaa cctacaaaaa agataacaaa     1500

gaagaaccgg caacgatccc gccggtgtct ctgaaagttt ccggcctgac cggtctgaaa     1560

gaactggatc tgagcggctt tgaccgtgaa acgctggcag gtctggatgc ggccacgctg     1620

accagtctgg aaaaagttga tatttccggc aataaactgg acctggcgcc gggtaccgaa     1680

aaccgccaga tttttgatac gatgctgagt accatctcca accatgttgg cagcaatgaa     1740

cagaccgtca aattcgacaa acaaaaaccg acgggccact acccggatac gtatggtaaa     1800

accagcctgc gtctgccggt cgccaacgaa aaagtggatc tgcagtctca actgctgttt     1860

ggcacggtta ccaatcaggg taccctgatt aacagcgaag cagattacaa ggcttaccaa     1920

aaccataaaa tcgcgggtcg ctcatttgtg gattcgaact accactacaa caacttcaaa     1980

gttagttacg aaaactacac cgttaaagtc acggattcca ccctgggcac cacgaccgat     2040

aaaacgctgg ccaccgacaa agaagaaacc tacaaagtcg atttctttag cccggcagac     2100

aaaacgaaag cggtgcatac cgccaaagtg attgttggcg atgaaaaaac catgatggtg     2160

aacctggctg aaggtgcgac ggttatcggc ggttccgcag acccggttaa cgctcgcaaa     2220

gtctttgatg gccagctggg tagtgaaacc gataatattt ccctgggttg ggactcaaaa     2280

cagtcgatta tcttcaaact gaaagaagac ggcctgatca aacactggcg tttctttaac     2340

gatagtgccc gcaatccgga aacgaccaac aaaccgattc aggaagcatc cctgcaaatc     2400

ttcaacatca aagattacaa cctggacaat ctgctggaaa acccgaataa attcgatgac     2460

gaaaaatact ggatcacggt ggatacctat agcgcgcagg gcgaacgtgc tacggcgttt     2520

agtaacaccc tgaacaatat tacgtccaaa tactggcgtg tggttttcga taccaaaggt     2580

gaccgctata gctctccggt cgtgccggaa ctgcagattc tgggctatcc gctgccgaat     2640

gctgatacga tcatgaaaac cgtgacgacc gcgaaagaac tgtcacagca aaaagataaa     2700

ttctcgcaga aaatgctgga cgaactgaaa attaaagaaa tggctctgga aaccagcctg     2760

aacagtaaaa ttttcgatgt tacggcgatc aatgctaacg ctggtgtgct gaaagactgt     2820

attgaaaaac gccaactgct gaaaaaaggc ggcggcggct ctggcggcgg cggctctggc     2880

ggcggcggct ctcaccacca ccaccaccac gaattcggcg gcggcggctc tggcggcggc     2940

ggctctggcg gcggcggctc tgcggtaacc gggacaacga aggctaacat caaacttttt     3000

agttttacag aggtaaacga cactaatccg ttgaacaatc tgaactttac cttaaaaaac     3060

tcgggaaaac ccttagtaga tatggtagtg ttattttccg cgaacattaa ctatgacgcg     3120

gccaacgata aggtcttcgt atcgaataat ccgaacgtac agcatctttt gaccaatcgt     3180

gcgaagtacc ttaagccgtt acaagacaag gggatcaagg tgattttgtc aatcttaggg     3240

aaccatgatc gctccgggat cgccaatttg agtacggctc gtgcgaaggc atttgctcag     3300

gaactgaaga atacttgcga tttgtataat ttagacgggg tattctttga tgatgagtac     3360

tctgcttacc aaacgccacc gccgagcggc ttcgtgacac ccagtaataa cgccgcagct     3420

cgccttgctt atgaaacaaa gcaggctatg ccaaacaagc tggtcacggt gtacgtctat     3480

tcccgcactt cgagttttcc cacagcggta gacggggtca acgccgggtc ctacgtagac     3540

tatgcgattc atgactacgg tggctcatac gacttggcta ctaattatcc ggggttggct     3600

aagtctggga tggtgatgtc tagtcaggag tttaaccagg gccgttacgc gactgcacaa     3660

gcattgcgca acattgtgac caagggctat ggaggccaca tgatctttgc catggacccc     3720

aatcgttcta atttcacgtc agggcaactg cccgcactga agctgattgc caaggagctt     3780

tacggggatg agcttgtgta cagcaacact ccttacagta aggattggtg ataa           3834


<210>  28
<211>  1806
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoF3-EndoH

<400>  28
atggctacag cgctggctgg ttctaacggg gtctgcatcg cgtattacat caccgatggg       60

cgtaatccga cgttcaaatt gaaagacatc ccggataaag tagacatggt aattcttttt      120

ggtcttaagt attggtcatt gcaggataca accaaattgc cagggggtac tggtatgatg      180

ggttcgttta aatcctacaa ggacctggac acccagattc gtagtcttca aagccgtgga      240

atcaaagtgt tgcagaacat tgacgacgac gtctcatggc agtcctcgaa gccgggtggg      300

ttcgcttccg ccgctgctta cggggatgct attaagagta tcgtaattga taagtggaag      360

ctggacggga ttagcttgga tattgagcat tcgggggcta aacccaaccc tatcccaact      420

tttcctggat atgccgcgac aggatataat ggctggtatt caggatctat ggcagccacg      480

cctgcctttc ttaatgttat ctcagagctt actaaatact ttggtacaac ggcaccgaat      540

aataagcaac ttcagattgc ttcgggtatt gacgtatatg cctggaataa aatcatggag      600

aactttcgta ataacttcaa ctacatccaa ttacagtcat acggagctaa tgtctctcgt      660

actcaactta tgatgaatta cgcaacggga actaataaaa ttcccgcctc taaaatggtt      720

ttcggcgcct acgcagaggg tggcactaac caggcaaatg acgtggaggt cgccaagtgg      780

acacctacgc agggcgcaaa gggcggtatg atgatctata cttacaattc gaacgtgagc      840

tatgcaaatg cggttcgcga cgcagtgaaa aatggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgcc ccggccccgg tgaagcaggg gccgacctcg     1020

gtggcctacg tcgaggtgaa caacaacagc atgctcaacg tcggcaagta caccctggcg     1080

gacggaggcg gcaacgcctt cgacgtagcc gtgatcttcg cggcgaacat caactacgac     1140

accggcacga agacggccta cctgcacttc aacgagaacg tgcagcgcgt ccttgacaac     1200

gctgtcacgc agatacggcc gttgcagcaa cagggcatca aggtcctcct ctcggtgctc     1260

ggcaaccacc agggcgccgg gttcgcgaac ttcccctcac agcaggcggc ttcggcgttc     1320

gcgaagcagc tctcggacgc cgtggcgaag tacggcctcg acggcgtcga cttcgacgac     1380

gaatacgccg agtacggcaa caacggcacc gcgcagccca acgacagttc gttcgtgcac     1440

ctggtgacgg cactgcgcgc gaacatgccc gacaagatca tcagcctcta caacatcggc     1500

ccggccgcgt cccgcctgtc gtacggcggt gtcgacgtct ccgacaagtt cgactacgcc     1560

tggaatccct actacggcac ctggcaggtc cccggcatcg cactgcccaa ggcgcagctg     1620

tcgccggcgg ccgtcgagat cggccggacc tcacggagca ccgtcgccga cctcgcccgt     1680

cgcaccgtcg acgaggggta cggcgtctat ctgacgtaca acctcgacgg cggcgatcgc     1740

accgccgacg tctccgcgtt caccagggag ctgtacggca gcgaggcggt ccggacgccg     1800

tgataa                                                                1806


<210>  29
<211>  1806
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoF2-EndoH

<400>  29
atggcggtaa accttagtaa tcttatcgct tataaaaata gtgaccatca gatcagtgcg       60

ggatattacc gtacatggcg tgacagcgcc acagccagtg gtaatcttcc tagtatgcgt      120

tggttgccag actcattgga catggtaatg gtattcccag actatactcc tccggaaaat      180

gcgtattgga acacactgaa gactaactac gtaccatacc tgcataagcg tggcacgaaa      240

gttattatca cattggggga ccttaactct gcaacgacca cgggagggca agattctatt      300

gggtattcat cgtgggccaa aggaatctat gataaatggg tgggcgagta taatcttgat      360

ggaatcgata ttgacatcga atcgtcaccg tccggtgcga ccttaacgaa gtttgttgcg      420

gcaacaaaag cgttgtcaaa gtattttgga ccaaagagtg ggacaggcaa gacctttgta      480

tacgatacca atcagaatcc gactaatttc tttatccaaa ctgccccacg ctacaactac      540

gtatttcttc aagcatacgg gcgctcgacc actaatctga cgacggtctc tggattatac      600

gccccctata tttcaatgaa acaatttctg cccggcttct ctttttacga agaaaacggt      660

tacccaggta attattggaa tgatgtgcgt tacccccaga acggtacagg ccgtgcctac      720

gactacgcgc gctggcagcc cgccacggga aaaaaaggag gggtgttcag ttatgccatc      780

gagcgcgacg cccctcttac atcgtcaaac gacaataccc tgcgtgcgcc taactttcgt      840

gtaacgaagg acttaatcaa aattatgaat cctggcggcg gcggctctgg cggcggcggc      900

tctggcggcg gcggctctca ccaccaccac caccacgaat tcggcggcgg cggctctggc      960

ggcggcggct ctggcggcgg cggctctgcc ccggccccgg tgaagcaggg gccgacctcg     1020

gtggcctacg tcgaggtgaa caacaacagc atgctcaacg tcggcaagta caccctggcg     1080

gacggaggcg gcaacgcctt cgacgtagcc gtgatcttcg cggcgaacat caactacgac     1140

accggcacga agacggccta cctgcacttc aacgagaacg tgcagcgcgt ccttgacaac     1200

gctgtcacgc agatacggcc gttgcagcaa cagggcatca aggtcctcct ctcggtgctc     1260

ggcaaccacc agggcgccgg gttcgcgaac ttcccctcac agcaggcggc ttcggcgttc     1320

gcgaagcagc tctcggacgc cgtggcgaag tacggcctcg acggcgtcga cttcgacgac     1380

gaatacgccg agtacggcaa caacggcacc gcgcagccca acgacagttc gttcgtgcac     1440

ctggtgacgg cactgcgcgc gaacatgccc gacaagatca tcagcctcta caacatcggc     1500

ccggccgcgt cccgcctgtc gtacggcggt gtcgacgtct ccgacaagtt cgactacgcc     1560

tggaatccct actacggcac ctggcaggtc cccggcatcg cactgcccaa ggcgcagctg     1620

tcgccggcgg ccgtcgagat cggccggacc tcacggagca ccgtcgccga cctcgcccgt     1680

cgcaccgtcg acgaggggta cggcgtctat ctgacgtaca acctcgacgg cggcgatcgc     1740

accgccgacg tctccgcgtt caccagggag ctgtacggca gcgaggcggt ccggacgccg     1800

tgataa                                                                1806


<210>  30
<211>  3780
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein EndoS-EndoH (or EndoSH)

<400>  30
atgccgtcaa tcgattcgct gcattatctg agcgaaaact ctaaaaaaga atttaaagaa       60

gaactgagca aagcgggcca ggaatctcaa aaagttaaag aaatcctggc aaaagctcag      120

caagccgata aacaggcaca agaactggct aaaatgaaaa ttccggaaaa aatcccgatg      180

aaaccgctgc atggtccgct gtacggcggt tatttccgta cctggcacga taaaacgtca      240

gacccgaccg aaaaagacaa agtcaactcg atgggcgaac tgccgaaaga agtggatctg      300

gcttttattt tccatgattg gaccaaagac tactctctgt tttggaaaga actggcaacg      360

aaacacgttc cgaaactgaa caaacagggt acgcgtgtca ttcgtaccat tccgtggcgc      420

ttcctggctg gcggtgataa ttcaggcatc gcggaagaca cctcgaaata tccgaacacg      480

ccggaaggta ataaagcgct ggccaaagca atcgtcgatg aatacgtgta caaatacaat      540

ctggacggcc tggatgtgga cgttgaacat gattcaattc cgaaagtgga taaaaaagaa      600

gacaccgccg gcgtggaacg ttcgatccag gtttttgaag aaattggtaa actgatcggc      660

ccgaaaggtg ttgataaaag ccgtctgttc atcatggatt ctacctatat ggccgacaaa      720

aatccgctga ttgaacgcgg tgcaccgtac atcaacctgc tgctggtcca ggtgtatggc      780

agccaaggtg aaaaaggcgg ttgggaaccg gtgtctaacc gtccggaaaa aaccatggaa      840

gaacgctggc agggctactc aaaatatatt cgtccggaac aatacatgat cggcttttcg      900

ttctatgaag aaaacgcgca ggaaggtaat ctgtggtacg atattaatag tcgcaaagat      960

gaagacaaag ccaacggcat taataccgat atcacgggta cccgtgcgga acgctatgcc     1020

cgttggcagc cgaaaaccgg cggtgttaaa ggcggtattt ttagctacgc gatcgatcgt     1080

gacggtgtcg cccatcagcc gaaaaaatac gcaaaacaaa aagagttcaa agatgctacc     1140

gacaacatct tccacagcga ttacagtgtc tccaaagcgc tgaaaaccgt gatgctgaaa     1200

gataaatctt acgatctgat cgacgaaaaa gattttccgg acaaagcgct gcgcgaagcc     1260

gttatggcac aggtcggcac ccgcaaaggt gacctggaac gttttaatgg cacgctgcgc     1320

ctggataacc cggccattca gagcctggaa ggtctgaata aattcaaaaa actggcacaa     1380

ctggacctga ttggcctgag ccgtatcacc aaactggatc gctctgtgct gccggccaac     1440

atgaaaccgg gtaaagacac gctggaaacc gttctggaaa cctacaaaaa agataacaaa     1500

gaagaaccgg caacgatccc gccggtgtct ctgaaagttt ccggcctgac cggtctgaaa     1560

gaactggatc tgagcggctt tgaccgtgaa acgctggcag gtctggatgc ggccacgctg     1620

accagtctgg aaaaagttga tatttccggc aataaactgg acctggcgcc gggtaccgaa     1680

aaccgccaga tttttgatac gatgctgagt accatctcca accatgttgg cagcaatgaa     1740

cagaccgtca aattcgacaa acaaaaaccg acgggccact acccggatac gtatggtaaa     1800

accagcctgc gtctgccggt cgccaacgaa aaagtggatc tgcagtctca actgctgttt     1860

ggcacggtta ccaatcaggg taccctgatt aacagcgaag cagattacaa ggcttaccaa     1920

aaccataaaa tcgcgggtcg ctcatttgtg gattcgaact accactacaa caacttcaaa     1980

gttagttacg aaaactacac cgttaaagtc acggattcca ccctgggcac cacgaccgat     2040

aaaacgctgg ccaccgacaa agaagaaacc tacaaagtcg atttctttag cccggcagac     2100

aaaacgaaag cggtgcatac cgccaaagtg attgttggcg atgaaaaaac catgatggtg     2160

aacctggctg aaggtgcgac ggttatcggc ggttccgcag acccggttaa cgctcgcaaa     2220

gtctttgatg gccagctggg tagtgaaacc gataatattt ccctgggttg ggactcaaaa     2280

cagtcgatta tcttcaaact gaaagaagac ggcctgatca aacactggcg tttctttaac     2340

gatagtgccc gcaatccgga aacgaccaac aaaccgattc aggaagcatc cctgcaaatc     2400

ttcaacatca aagattacaa cctggacaat ctgctggaaa acccgaataa attcgatgac     2460

gaaaaatact ggatcacggt ggatacctat agcgcgcagg gcgaacgtgc tacggcgttt     2520

agtaacaccc tgaacaatat tacgtccaaa tactggcgtg tggttttcga taccaaaggt     2580

gaccgctata gctctccggt cgtgccggaa ctgcagattc tgggctatcc gctgccgaat     2640

gctgatacga tcatgaaaac cgtgacgacc gcgaaagaac tgtcacagca aaaagataaa     2700

ttctcgcaga aaatgctgga cgaactgaaa attaaagaaa tggctctgga aaccagcctg     2760

aacagtaaaa ttttcgatgt tacggcgatc aatgctaacg ctggtgtgct gaaagactgt     2820

attgaaaaac gccaactgct gaaaaaaggc ggcggcggct ctggcggcgg cggctctggc     2880

ggcggcggct ctcaccacca ccaccaccac gaattcggcg gcggcggctc tggcggcggc     2940

ggctctggcg gcggcggctc tgccccggcc ccggtgaagc aggggccgac ctcggtggcc     3000

tacgtcgagg tgaacaacaa cagcatgctc aacgtcggca agtacaccct ggcggacgga     3060

ggcggcaacg ccttcgacgt agccgtgatc ttcgcggcga acatcaacta cgacaccggc     3120

acgaagacgg cctacctgca cttcaacgag aacgtgcagc gcgtccttga caacgctgtc     3180

acgcagatac ggccgttgca gcaacagggc atcaaggtcc tcctctcggt gctcggcaac     3240

caccagggcg ccgggttcgc gaacttcccc tcacagcagg cggcttcggc gttcgcgaag     3300

cagctctcgg acgccgtggc gaagtacggc ctcgacggcg tcgacttcga cgacgaatac     3360

gccgagtacg gcaacaacgg caccgcgcag cccaacgaca gttcgttcgt gcacctggtg     3420

acggcactgc gcgcgaacat gcccgacaag atcatcagcc tctacaacat cggcccggcc     3480

gcgtcccgcc tgtcgtacgg cggtgtcgac gtctccgaca agttcgacta cgcctggaat     3540

ccctactacg gcacctggca ggtccccggc atcgcactgc ccaaggcgca gctgtcgccg     3600

gcggccgtcg agatcggccg gacctcacgg agcaccgtcg ccgacctcgc ccgtcgcacc     3660

gtcgacgagg ggtacggcgt ctatctgacg tacaacctcg acggcggcga tcgcaccgcc     3720

gacgtctccg cgttcaccag ggagctgtac ggcagcgagg cggtccggac gccgtgataa     3780


<210>  31
<211>  3726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding fusion protein His6-EndoS-EndoH 
       (EndoS-EndoH without GS-linker)

<400>  31
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgccgtcaa tcgattcgct gcattatctg agcgaaaact ctaaaaaaga atttaaagaa      120

gaactgagca aagcgggcca ggaatctcaa aaagttaaag aaatcctggc aaaagctcag      180

caagccgata aacaggcaca agaactggct aaaatgaaaa ttccggaaaa aatcccgatg      240

aaaccgctgc atggtccgct gtacggcggt tatttccgta cctggcacga taaaacgtca      300

gacccgaccg aaaaagacaa agtcaactcg atgggcgaac tgccgaaaga agtggatctg      360

gcttttattt tccatgattg gaccaaagac tactctctgt tttggaaaga actggcaacg      420

aaacacgttc cgaaactgaa caaacagggt acgcgtgtca ttcgtaccat tccgtggcgc      480

ttcctggctg gcggtgataa ttcaggcatc gcggaagaca cctcgaaata tccgaacacg      540

ccggaaggta ataaagcgct ggccaaagca atcgtcgatg aatacgtgta caaatacaat      600

ctggacggcc tggatgtgga cgttgaacat gattcaattc cgaaagtgga taaaaaagaa      660

gacaccgccg gcgtggaacg ttcgatccag gtttttgaag aaattggtaa actgatcggc      720

ccgaaaggtg ttgataaaag ccgtctgttc atcatggatt ctacctatat ggccgacaaa      780

aatccgctga ttgaacgcgg tgcaccgtac atcaacctgc tgctggtcca ggtgtatggc      840

agccaaggtg aaaaaggcgg ttgggaaccg gtgtctaacc gtccggaaaa aaccatggaa      900

gaacgctggc agggctactc aaaatatatt cgtccggaac aatacatgat cggcttttcg      960

ttctatgaag aaaacgcgca ggaaggtaat ctgtggtacg atattaatag tcgcaaagat     1020

gaagacaaag ccaacggcat taataccgat atcacgggta cccgtgcgga acgctatgcc     1080

cgttggcagc cgaaaaccgg cggtgttaaa ggcggtattt ttagctacgc gatcgatcgt     1140

gacggtgtcg cccatcagcc gaaaaaatac gcaaaacaaa aagagttcaa agatgctacc     1200

gacaacatct tccacagcga ttacagtgtc tccaaagcgc tgaaaaccgt gatgctgaaa     1260

gataaatctt acgatctgat cgacgaaaaa gattttccgg acaaagcgct gcgcgaagcc     1320

gttatggcac aggtcggcac ccgcaaaggt gacctggaac gttttaatgg cacgctgcgc     1380

ctggataacc cggccattca gagcctggaa ggtctgaata aattcaaaaa actggcacaa     1440

ctggacctga ttggcctgag ccgtatcacc aaactggatc gctctgtgct gccggccaac     1500

atgaaaccgg gtaaagacac gctggaaacc gttctggaaa cctacaaaaa agataacaaa     1560

gaagaaccgg caacgatccc gccggtgtct ctgaaagttt ccggcctgac cggtctgaaa     1620

gaactggatc tgagcggctt tgaccgtgaa acgctggcag gtctggatgc ggccacgctg     1680

accagtctgg aaaaagttga tatttccggc aataaactgg acctggcgcc gggtaccgaa     1740

aaccgccaga tttttgatac gatgctgagt accatctcca accatgttgg cagcaatgaa     1800

cagaccgtca aattcgacaa acaaaaaccg acgggccact acccggatac gtatggtaaa     1860

accagcctgc gtctgccggt cgccaacgaa aaagtggatc tgcagtctca actgctgttt     1920

ggcacggtta ccaatcaggg taccctgatt aacagcgaag cagattacaa ggcttaccaa     1980

aaccataaaa tcgcgggtcg ctcatttgtg gattcgaact accactacaa caacttcaaa     2040

gttagttacg aaaactacac cgttaaagtc acggattcca ccctgggcac cacgaccgat     2100

aaaacgctgg ccaccgacaa agaagaaacc tacaaagtcg atttctttag cccggcagac     2160

aaaacgaaag cggtgcatac cgccaaagtg attgttggcg atgaaaaaac catgatggtg     2220

aacctggctg aaggtgcgac ggttatcggc ggttccgcag acccggttaa cgctcgcaaa     2280

gtctttgatg gccagctggg tagtgaaacc gataatattt ccctgggttg ggactcaaaa     2340

cagtcgatta tcttcaaact gaaagaagac ggcctgatca aacactggcg tttctttaac     2400

gatagtgccc gcaatccgga aacgaccaac aaaccgattc aggaagcatc cctgcaaatc     2460

ttcaacatca aagattacaa cctggacaat ctgctggaaa acccgaataa attcgatgac     2520

gaaaaatact ggatcacggt ggatacctat agcgcgcagg gcgaacgtgc tacggcgttt     2580

agtaacaccc tgaacaatat tacgtccaaa tactggcgtg tggttttcga taccaaaggt     2640

gaccgctata gctctccggt cgtgccggaa ctgcagattc tgggctatcc gctgccgaat     2700

gctgatacga tcatgaaaac cgtgacgacc gcgaaagaac tgtcacagca aaaagataaa     2760

ttctcgcaga aaatgctgga cgaactgaaa attaaagaaa tggctctgga aaccagcctg     2820

aacagtaaaa ttttcgatgt tacggcgatc aatgctaacg ctggtgtgct gaaagactgt     2880

attgaaaaac gccaactgct gaaaaaagcc ccggccccgg tgaagcaggg gccgacctcg     2940

gtggcctacg tcgaggtgaa caacaacagc atgctcaacg tcggcaagta caccctggcg     3000

gacggaggcg gcaacgcctt cgacgtagcc gtgatcttcg cggcgaacat caactacgac     3060

accggcacga agacggccta cctgcacttc aacgagaacg tgcagcgcgt ccttgacaac     3120

gctgtcacgc agatacggcc gttgcagcaa cagggcatca aggtcctcct ctcggtgctc     3180

ggcaaccacc agggcgccgg gttcgcgaac ttcccctcac agcaggcggc ttcggcgttc     3240

gcgaagcagc tctcggacgc cgtggcgaag tacggcctcg acggcgtcga cttcgacgac     3300

gaatacgccg agtacggcaa caacggcacc gcgcagccca acgacagttc gttcgtgcac     3360

ctggtgacgg cactgcgcgc gaacatgccc gacaagatca tcagcctcta caacatcggc     3420

ccggccgcgt cccgcctgtc gtacggcggt gtcgacgtct ccgacaagtt cgactacgcc     3480

tggaatccct actacggcac ctggcaggtc cccggcatcg cactgcccaa ggcgcagctg     3540

tcgccggcgg ccgtcgagat cggccggacc tcacggagca ccgtcgccga cctcgcccgt     3600

cgcaccgtcg acgaggggta cggcgtctat ctgacgtaca acctcgacgg cggcgatcgc     3660

accgccgacg tctccgcgtt caccagggag ctgtacggca gcgaggcggt ccggacgccg     3720

tgataa                                                                3726


<210>  32
<211>  1248
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding His6-TnGalNAcT(33-421)


<220>
<221>  sig_peptide
<222>  (4)..(57)

<400>  32
atgaattttg gactgaggct gattttcctg gtgctgaccc tgaaaggcgt ccagtgtcat       60

caccatcacc atcactcccc gcttcgcaca tatctttaca ctccattata caatgccacc      120

cagcccacac tcagaaacgt cgagaggctg gcagctaact ggccaaagaa gatccctagt      180

aattatatag aagatagcga agagtatagc atcaagaata tttctttgag caaccacaca      240

actagagcat ctgtggtaca tcctccttcc tctatcaccg aaacggcaag caaactggat      300

aagaatatga ccatccaaga cggcgccttt gctatgatta gcccgacgcc cttgcttatc      360

accaaattga tggatagcat caaatcttat gttactaccg aggatggggt taagaaagcc      420

gaagccgtcg taactctccc cctctgtgat agcatgcctc ctgaccttgg tcctattact      480

cttaacaaaa ccgagctcga gctcgaatgg gttgagaaaa agttccctga ggtcgagtgg      540

ggtggacgtt atagtccccc caactgcaca gctaggcatc gcgtagcaat catagtcccg      600

taccgagaca gacagcaaca cctggcaatc ttcttaaatc acatgcaccc cttcctgatg      660

aaacagcaga tcgaatatgg catctttatc gtggagcagg aaggaaacaa ggactttaac      720

cgtgcgaaac ttatgaacgt cggctttgtt gaaagtcaaa aactcgttgc cgagggatgg      780

cagtgtttcg tttttcatga catagacctg ctcccactgg acactagaaa cctctatagc      840

tgcccgagac agccacgcca catgagcgct tccattgaca aacttcactt taagctgcct      900

tacgaagaca tcttcggtgg cgtgtcagcc atgactctgg aacagttcac ccgagtgaat      960

ggattttcaa ataaatactg gggatggggg ggagaggacg acgatatgag ttatcggctt     1020

aagaaaatca actaccatat tgcaagatat aaaatgtcca tcgcccgata cgccatgttg     1080

gaccacaaga agtcaacacc caatcctaag cggtaccaat tactctcaca gacctcaaag     1140

acattccaga aagacgggct gagcaccctg gaatatgagc tggtgcaagt cgttcaatat     1200

catctgtata ctcacatcct ggttaatatt gacgagaggt cctgataa                  1248


<210>  33
<211>  395
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His6-TnGalNAcT(33-421)

<400>  33

His His His His His His Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro 
1               5                   10                  15      


Leu Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala 
            20                  25                  30          


Ala Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu 
        35                  40                  45              


Glu Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala 
    50                  55                  60                  


Ser Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu 
65                  70                  75                  80  


Asp Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro 
                85                  90                  95      


Thr Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val 
            100                 105                 110         


Thr Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro 
        115                 120                 125             


Leu Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys 
    130                 135                 140                 


Thr Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu 
145                 150                 155                 160 


Trp Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val 
                165                 170                 175     


Ala Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe 
            180                 185                 190         


Leu Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly 
        195                 200                 205             


Ile Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys 
    210                 215                 220                 


Leu Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly 
225                 230                 235                 240 


Trp Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr 
                245                 250                 255     


Arg Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser 
            260                 265                 270         


Ile Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser 
    290                 295                 300                 


Asn Lys Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg 
305                 310                 315                 320 


Leu Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala 
                325                 330                 335     


Arg Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg 
            340                 345                 350         


Tyr Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu 
        355                 360                 365             


Ser Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr 
    370                 375                 380                 


Thr His Ile Leu Val Asn Ile Asp Glu Arg Ser 
385                 390                 395 


