               SEQUENCE LISTING

<110> Sanofi Pasteur

<120> Meningitis vaccines comprising subtilinases

<130> PR74498

<160> 6

<170> BiSSAP 1.2

<210> 1
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<400> 1
Met Arg Thr Thr Pro Thr Phe Pro Thr Lys Thr Phe Lys Pro Thr Ala 
1               5                   10                  15      
Met Ala Leu Ala Val Ala Thr Thr Leu Ser Ala Cys Leu Gly Gly Gly 
            20                  25                  30          
Gly Gly Gly Thr Ser Ala Pro Asp Phe Asn Ala Gly Gly Thr Gly Ile 
        35                  40                  45              
Gly Ser Asn Ser Arg Ala Thr Thr Ala Lys Ser Ala Ala Val Ser Tyr 
    50                  55                  60                  
Ala Gly Ile Lys Asn Glu Met Cys Lys Asp Arg Ser Met Leu Cys Ala 
65                  70                  75                  80  
Gly Arg Asp Asp Val Ala Val Thr Asp Arg Asp Ala Lys Ile Asn Ala 
                85                  90                  95      
Pro Pro Pro Asn Leu His Thr Gly Asp Phe Pro Asn Pro Asn Asp Ala 
            100                 105                 110         
Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala Gly Tyr Thr 
        115                 120                 125             
Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu Ser Val Gly 
    130                 135                 140                 
Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His Gly Tyr Asn 
145                 150                 155                 160 
Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu Ala Pro Glu 
                165                 170                 175     
Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp Glu Ala Val 
            180                 185                 190         
Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val Lys Glu Ile 
        195                 200                 205             
Gly His Ile Asp Leu Val Ser His Ile Ile Gly Gly Arg Ser Val Asp 
    210                 215                 220                 
Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu His Ile Met 
225                 230                 235                 240 
Asn Thr Asn Asp Glu Thr Lys Asn Glu Met Met Val Ala Ala Ile Arg 
                245                 250                 255     
Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile Val Asn Asn 
            260                 265                 270         
Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu Phe Gln Ile 
        275                 280                 285             
Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp Tyr Ser Gly 
    290                 295                 300                 
Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln Ser Asp Tyr 
305                 310                 315                 320 
Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu Phe Ile Phe 
                325                 330                 335     
Ser Thr Gly Asn Asp Ala Gln Ala Gln Pro Asn Thr Tyr Ala Leu Leu 
            340                 345                 350         
Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr Val Ala Gly 
        355                 360                 365             
Val Asp Arg Ser Gly Glu Lys Phe Lys Arg Glu Met Tyr Gly Glu Pro 
    370                 375                 380                 
Gly Thr Glu Pro Leu Glu Tyr Gly Ser Asn His Cys Gly Ile Thr Ala 
385                 390                 395                 400 
Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg Phe Thr Arg 
                405                 410                 415     
Thr Asn Pro Ile Gln Ile Ala Gly Thr Ser Phe Ser Ala Pro Ile Val 
            420                 425                 430         
Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp Met Ser Asn 
        435                 440                 445             
Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp Ile Gly Ala 
    450                 455                 460                 
Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp Ala Gly Lys 
465                 470                 475                 480 
Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe Thr Ala Asp 
                485                 490                 495     
Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn Asp Ile Ser 
            500                 505                 510         
Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu Gln Leu His 
        515                 520                 525             
Gly Asn Asn Thr Tyr Thr Gly Lys Thr Ile Ile Glu Gly Gly Ser Leu 
    530                 535                 540                 
Val Leu Tyr Gly Asn Asn Lys Ser Asp Met Arg Val Glu Thr Lys Gly 
545                 550                 555                 560 
Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu Asn Ser Asp 
                565                 570                 575     
Gly Ile Val Tyr Leu Ala Asp Thr Asp Gln Ser Gly Ala Asn Glu Thr 
            580                 585                 590         
Val His Ile Lys Gly Ser Leu Gln Leu Asp Gly Lys Gly Thr Leu Tyr 
        595                 600                 605             
Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala Ile Ile Gly 
    610                 615                 620                 
Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly Tyr Leu Asn 
625                 630                 635                 640 
Ser Thr Gly Arg Arg Val Pro Phe Leu Ser Ala Ala Lys Ile Gly Gln 
                645                 650                 655     
Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly Leu Leu Ala 
            660                 665                 670         
Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly Asp Thr Leu 
        675                 680                 685             
Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala Ser Ala Ala 
    690                 695                 700                 
Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu Gln Gly Gly 
705                 710                 715                 720 
Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser Glu Ser Ser 
                725                 730                 735     
Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg Thr Asp Met 
            740                 745                 750         
Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala Ala Ala Val 
        755                 760                 765             
Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn Ser Leu Ala 
    770                 775                 780                 
Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp Met Gln Gly 
785                 790                 795                 800 
Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn Gly Thr Gly 
                805                 810                 815     
Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr Trp Glu Gln 
            820                 825                 830         
Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr Val Gly Ile 
        835                 840                 845             
Ala Ala Lys Thr Gly Glu Asn Thr Thr Ala Ala Ala Thr Leu Gly Met 
    850                 855                 860                 
Gly Arg Ser Thr Trp Ser Glu Asn Ser Ala Asn Ala Lys Thr Asp Ser 
865                 870                 875                 880 
Ile Ser Leu Phe Ala Gly Ile Arg His Asp Ala Gly Asp Ile Gly Tyr 
                885                 890                 895     
Leu Lys Gly Leu Phe Ser Tyr Gly Arg Tyr Lys Asn Ser Ile Ser Arg 
            900                 905                 910         
Ser Thr Gly Ala Asp Glu His Ala Glu Gly Ser Val Asn Gly Thr Leu 
        915                 920                 925             
Met Gln Leu Gly Ala Leu Gly Gly Val Asn Val Pro Phe Ala Ala Thr 
    930                 935                 940                 
Gly Asp Leu Thr Val Glu Gly Gly Leu Arg Tyr Asp Leu Leu Lys Gln 
945                 950                 955                 960 
Asp Ala Phe Ala Glu Lys Gly Ser Ala Leu Gly Trp Ser Gly Asn Ser 
                965                 970                 975     
Leu Thr Glu Gly Thr Leu Val Gly Leu Ala Gly Leu Lys Leu Ser Gln 
            980                 985                 990         
Pro Leu Ser Asp Lys Ala Val Leu Phe Ala Thr Ala Gly Val Glu Arg 
        995                 1000                1005            
Asp Leu Asn Gly Arg Asp Tyr Thr Val Thr Gly Gly Phe Thr Gly Ala 
    1010                1015                1020                
Thr Ala Ala Thr Gly Lys Thr Gly Ala Arg Asn Met Pro His Thr Arg 
1025                1030                1035                1040
Leu Val Ala Gly Leu Gly Ala Asp Val Glu Phe Gly Asn Gly Trp Asn 
                1045                1050                1055    
Gly Leu Ala Arg Tyr Ser Tyr Ala Gly Ser Lys Gln Tyr Gly Asn His 
            1060                1065                1070        
Ser Gly Arg Val Gly Val Gly Tyr Arg Phe 
        1075                1080        

<210> 2
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<220> 
<221> source
<222> 1..3249
<223> /mol_type="unassigned DNA"
      /organism="Neisseria meningitidis"

<400> 2
atgcgaacga ccccaacctt ccctacaaaa actttcaaac cgactgccat ggcgttagct       60

gttgcaacaa cactttctgc ctgcttaggc ggcggcggag gcggcacttc tgcgcccgac      120

ttcaatgcag gcggtaccgg tatcggcagc aacagcagag caacaacagc gaaatcagca      180

gcagtatctt acgccggtat caagaacgaa atgtgcaaag acagaagcat gctctgtgcc      240

ggtcgggatg acgttgcggt tacagacagg gatgccaaaa tcaatgcccc ccccccgaat      300

ctgcataccg gagactttcc aaacccaaat gacgcataca agaatttgat caacctcaaa      360

cctgcaattg aagcaggcta tacaggacgc ggggtagagg taggtatcgt cgacacaggc      420

gaatccgtcg gcagcatatc ctttcccgaa ctgtatggca gaaaagaaca cggctataac      480

gaaaattaca aaaactatac ggcgtatatg cggaaggaag cgcctgaaga cggaggcggt      540

aaagacattg aagcttcttt cgacgatgag gccgttatag agactgaagc aaagccgacg      600

gatatccgcc acgtaaaaga aatcggacac atcgatttgg tctcccatat tattggcggg      660

cgttccgtgg acggcagacc tgcaggcggt attgcgcccg atgcgacgct acacataatg      720

aatacgaatg atgaaaccaa gaacgaaatg atggttgcag ccatccgcaa tgcatgggtc      780

aagctgggcg aacgtggcgt gcgcatcgtc aataacagtt ttggaacaac atcgagggca      840

ggcactgccg accttttcca aatagccaat tcggaggagc agtaccgcca agcgttgctc      900

gactattccg gcggtgataa aacagacgag ggtatccgcc tgatgcaaca gagcgattac      960

ggcaacctgt cctaccacat ccgtaataaa aacatgcttt tcatcttttc gacaggcaat     1020

gacgcacaag ctcagcccaa cacatatgcc ctattgccat tttatgaaaa agacgctcaa     1080

aaaggcatta tcacagtcgc aggcgtagac cgcagtggag aaaagttcaa acgggaaatg     1140

tatggagaac cgggtacaga accgcttgag tatggctcca accattgcgg aattactgcc     1200

atgtggtgcc tgtcggcacc ctatgaagca agcgtccgtt tcacccgtac aaacccgatt     1260

caaattgccg gaacatcctt ttccgcaccc atcgtaaccg gcacggcggc tctgctgctg     1320

cagaaatacc cgtggatgag caacgacaac ctgcgtacca cgttgctgac gacggctcag     1380

gacatcggtg cagtcggcgt ggacagcaag ttcggctggg gactgctgga tgcgggtaag     1440

gccatgaacg gacccgcgtc ctttccgttc ggcgacttta ccgccgatac gaaaggtaca     1500

tccgatattg cctactcctt ccgtaacgac atttcaggca cgggcggcct gatcaaaaaa     1560

ggcggcagcc aactgcaact gcacggcaac aacacctata cgggcaaaac cattatcgaa     1620

ggcggttcgc tggtgttgta cggcaacaac aaatcggata tgcgcgtcga aaccaaaggt     1680

gcgctgattt ataacggggc ggcatccggc ggcagcctga acagcgacgg cattgtctat     1740

ctggcagata ccgaccaatc cggcgcaaac gaaaccgtac acatcaaagg cagtctgcag     1800

ctggacggca aaggtacgct gtacacacgt ttgggcaaac tgctgaaagt ggacggtacg     1860

gcgattatcg gcggcaagct gtacatgtcg gcacgcggca agggggcagg ctatctcaac     1920

agtaccggac gacgtgttcc cttcctgagt gccgccaaaa tcgggcagga ttattctttc     1980

ttcacaaaca tcgaaaccga cggcggcctg ctggcttccc tcgacagcgt cgaaaaaaca     2040

gcgggcagtg aaggcgacac gctgtcctat tatgtccgtc gcggcaatgc ggcacggact     2100

gcttcggcag cggcacattc cgcgcccgcc ggtctgaaac acgccgtaga acagggcggc     2160

agcaatctgg aaaacctgat ggtcgaactg gatgcctccg aatcatccgc aacacccgag     2220

acggttgaaa ctgcggcagc cgaccgcaca gatatgccgg gcatccgccc ctacggcgca     2280

actttccgcg cagcggcagc cgtacagcat gcgaatgccg ccgacggtgt acgcatcttc     2340

aacagtctcg ccgctaccgt ctatgccgac agtaccgccg cccatgccga tatgcaggga     2400

cgccgcctga aagccgtatc ggacgggttg gaccacaacg gcacgggtct gcgcgtcatc     2460

gcgcaaaccc aacaggacgg tggaacgtgg gaacagggcg gtgttgaagg caaaatgcgc     2520

ggcagtaccc aaaccgtcgg cattgccgcg aaaaccggcg aaaatacgac agcagccgcc     2580

acactgggca tgggacgcag cacatggagc gaaaacagtg caaatgcaaa aaccgacagc     2640

attagtctgt ttgcaggcat acggcacgat gcgggcgata tcggctatct caaaggcctg     2700

ttctcctacg gacgctacaa aaacagcatc agccgcagca ccggtgcgga cgaacatgcg     2760

gaaggcagcg tcaacggcac gctgatgcag ctgggcgcac tgggcggtgt caacgttccg     2820

tttgccgcaa cgggagattt gacggtcgaa ggcggtctgc gctacgacct gctcaaacag     2880

gatgcattcg ccgaaaaagg cagtgctttg ggctggagcg gcaacagcct cactgaaggc     2940

acgctggtcg gactcgcggg tctgaagctg tcgcaaccct tgagcgataa agccgtcctg     3000

tttgcaacgg cgggcgtgga acgcgacctg aacggacgcg actacacggt aacgggcggc     3060

tttaccggcg cgactgcagc aaccggcaag acgggggcac gcaatatgcc gcacacccgt     3120

ctggttgccg gcctgggcgc ggatgtcgaa ttcggcaacg gctggaacgg cttggcacgt     3180

tacagctacg ccggttccaa acagtacggc aaccacagcg gacgagtcgg cgtaggctac     3240

cggttctga                                                             3249


<210> 3
<211> 824
<212> PRT
<213> Neisseria meningitidis


<400> 3
Gly Gly Gly Gly Gly Gly Thr Ser Ala Pro Asp Phe Asn Ala Gly Gly 
1               5                   10                  15      
Thr Gly Ile Gly Ser Asn Ser Arg Ala Thr Thr Ala Lys Ser Ala Ala 
            20                  25                  30          
Val Ser Tyr Ala Gly Ile Lys Asn Glu Met Cys Lys Asp Arg Ser Met 
        35                  40                  45              
Leu Cys Ala Gly Arg Asp Asp Val Ala Val Thr Asp Arg Asp Ala Lys 
    50                  55                  60                  
Ile Asn Ala Pro Pro Pro Asn Leu His Thr Gly Asp Phe Pro Asn Pro 
65                  70                  75                  80  
Asn Asp Ala Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala 
                85                  90                  95      
Gly Tyr Thr Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu 
            100                 105                 110         
Ser Val Gly Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His 
        115                 120                 125             
Gly Tyr Asn Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu 
    130                 135                 140                 
Ala Pro Glu Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp 
145                 150                 155                 160 
Glu Ala Val Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val 
                165                 170                 175     
Lys Glu Ile Gly His Ile Asp Leu Val Ser His Ile Ile Gly Gly Arg 
            180                 185                 190         
Ser Val Asp Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu 
        195                 200                 205             
His Ile Met Asn Thr Asn Asp Glu Thr Lys Asn Glu Met Met Val Ala 
    210                 215                 220                 
Ala Ile Arg Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile 
225                 230                 235                 240 
Val Asn Asn Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu 
                245                 250                 255     
Phe Gln Ile Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp 
            260                 265                 270         
Tyr Ser Gly Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln 
        275                 280                 285             
Ser Asp Tyr Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu 
    290                 295                 300                 
Phe Ile Phe Ser Thr Gly Asn Asp Ala Gln Ala Gln Pro Asn Thr Tyr 
305                 310                 315                 320 
Ala Leu Leu Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr 
                325                 330                 335     
Val Ala Gly Val Asp Arg Ser Gly Glu Lys Phe Lys Arg Glu Met Tyr 
            340                 345                 350         
Gly Glu Pro Gly Thr Glu Pro Leu Glu Tyr Gly Ser Asn His Cys Gly 
        355                 360                 365             
Ile Thr Ala Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg 
    370                 375                 380                 
Phe Thr Arg Thr Asn Pro Ile Gln Ile Ala Gly Thr Ala Phe Ser Ala 
385                 390                 395                 400 
Pro Ile Val Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp 
                405                 410                 415     
Met Ser Asn Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp 
            420                 425                 430         
Ile Gly Ala Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp 
        435                 440                 445             
Ala Gly Lys Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe 
    450                 455                 460                 
Thr Ala Asp Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn 
465                 470                 475                 480 
Asp Ile Ser Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu 
                485                 490                 495     
Gln Leu His Gly Asn Asn Thr Tyr Thr Gly Lys Thr Ile Ile Glu Gly 
            500                 505                 510         
Gly Ser Leu Val Leu Tyr Gly Asn Asn Lys Ser Asp Met Arg Val Glu 
        515                 520                 525             
Thr Lys Gly Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu 
    530                 535                 540                 
Asn Ser Asp Gly Ile Val Tyr Leu Ala Asp Thr Asp Gln Ser Gly Ala 
545                 550                 555                 560 
Asn Glu Thr Val His Ile Lys Gly Ser Leu Gln Leu Asp Gly Lys Gly 
                565                 570                 575     
Thr Leu Tyr Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala 
            580                 585                 590         
Ile Ile Gly Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly 
        595                 600                 605             
Tyr Leu Asn Ser Thr Gly Arg Arg Val Pro Phe Leu Ser Ala Ala Lys 
    610                 615                 620                 
Ile Gly Gln Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly 
625                 630                 635                 640 
Leu Leu Ala Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly 
                645                 650                 655     
Asp Thr Leu Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala 
            660                 665                 670         
Ser Ala Ala Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu 
        675                 680                 685             
Gln Gly Gly Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser 
    690                 695                 700                 
Glu Ser Ser Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg 
705                 710                 715                 720 
Thr Asp Met Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala 
                725                 730                 735     
Ala Ala Val Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn 
            740                 745                 750         
Ser Leu Ala Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp 
        755                 760                 765             
Met Gln Gly Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn 
    770                 775                 780                 
Gly Thr Gly Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr 
785                 790                 795                 800 
Trp Glu Gln Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr 
                805                 810                 815     
Val Gly Ile Ala Ala Lys Thr Gly 
            820                 

<210> 4
<211> 824
<212> PRT
<213> Neisseria meningitidis


<400> 4
Gly Gly Gly Gly Gly Gly Thr Ser Ala Pro Asp Phe Asn Ala Gly Gly 
1               5                   10                  15      
Thr Gly Ile Gly Ser Asn Ser Arg Ala Thr Thr Ala Lys Ser Ala Ala 
            20                  25                  30          
Val Ser Tyr Ala Gly Ile Lys Asn Glu Met Cys Lys Asp Arg Ser Met 
        35                  40                  45              
Leu Cys Ala Gly Arg Asp Asp Val Ala Val Thr Asp Arg Asp Ala Lys 
    50                  55                  60                  
Ile Asn Ala Pro Pro Pro Asn Leu His Thr Gly Asp Phe Pro Asn Pro 
65                  70                  75                  80  
Asn Asp Ala Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala 
                85                  90                  95      
Gly Tyr Thr Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu 
            100                 105                 110         
Ser Val Gly Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His 
        115                 120                 125             
Gly Tyr Asn Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu 
    130                 135                 140                 
Ala Pro Glu Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp 
145                 150                 155                 160 
Glu Ala Val Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val 
                165                 170                 175     
Lys Glu Ile Gly His Ile Asp Leu Val Ser His Ile Ile Gly Gly Arg 
            180                 185                 190         
Ser Val Asp Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu 
        195                 200                 205             
His Ile Met Asn Thr Asn Asp Glu Thr Lys Asn Glu Met Met Val Ala 
    210                 215                 220                 
Ala Ile Arg Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile 
225                 230                 235                 240 
Val Asn Asn Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu 
                245                 250                 255     
Phe Gln Ile Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp 
            260                 265                 270         
Tyr Ser Gly Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln 
        275                 280                 285             
Ser Asp Tyr Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu 
    290                 295                 300                 
Phe Ile Phe Ser Thr Gly Asn Asp Ala Gln Ala Gln Pro Asn Thr Tyr 
305                 310                 315                 320 
Ala Leu Leu Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr 
                325                 330                 335     
Val Ala Gly Val Asp Arg Ser Gly Glu Lys Phe Lys Arg Glu Met Tyr 
            340                 345                 350         
Gly Glu Pro Gly Thr Glu Pro Leu Glu Tyr Gly Ser Asn His Cys Gly 
        355                 360                 365             
Ile Thr Ala Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg 
    370                 375                 380                 
Phe Thr Arg Thr Asn Pro Ile Gln Ile Ala Gly Thr Ser Phe Ser Ala 
385                 390                 395                 400 
Pro Ile Val Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp 
                405                 410                 415     
Met Ser Asn Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp 
            420                 425                 430         
Ile Gly Ala Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp 
        435                 440                 445             
Ala Gly Lys Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe 
    450                 455                 460                 
Thr Ala Asp Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn 
465                 470                 475                 480 
Asp Ile Ser Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu 
                485                 490                 495     
Gln Leu His Gly Asn Asn Thr Tyr Thr Gly Lys Thr Ile Ile Glu Gly 
            500                 505                 510         
Gly Ser Leu Val Leu Tyr Gly Asn Asn Lys Ser Asp Met Arg Val Glu 
        515                 520                 525             
Thr Lys Gly Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu 
    530                 535                 540                 
Asn Ser Asp Gly Ile Val Tyr Leu Ala Asp Thr Asp Gln Ser Gly Ala 
545                 550                 555                 560 
Asn Glu Thr Val His Ile Lys Gly Ser Leu Gln Leu Asp Gly Lys Gly 
                565                 570                 575     
Thr Leu Tyr Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala 
            580                 585                 590         
Ile Ile Gly Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly 
        595                 600                 605             
Tyr Leu Asn Ser Thr Gly Arg Arg Val Pro Phe Leu Ser Ala Ala Lys 
    610                 615                 620                 
Ile Gly Gln Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly 
625                 630                 635                 640 
Leu Leu Ala Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly 
                645                 650                 655     
Asp Thr Leu Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala 
            660                 665                 670         
Ser Ala Ala Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu 
        675                 680                 685             
Gln Gly Gly Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser 
    690                 695                 700                 
Glu Ser Ser Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg 
705                 710                 715                 720 
Thr Asp Met Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala 
                725                 730                 735     
Ala Ala Val Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn 
            740                 745                 750         
Ser Leu Ala Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp 
        755                 760                 765             
Met Gln Gly Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn 
    770                 775                 780                 
Gly Thr Gly Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr 
785                 790                 795                 800 
Trp Glu Gln Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr 
                805                 810                 815     
Val Gly Ile Ala Ala Lys Thr Gly 
            820                 

<210> 5
<211> 1053
<212> PRT
<213> Neisseria meningitidis


<400> 5
Gly Gly Gly Gly Gly Gly Thr Ser Ala Pro Asp Phe Asn Ala Gly Gly 
1               5                   10                  15      
Thr Gly Ile Gly Ser Asn Ser Arg Ala Thr Thr Ala Lys Ser Ala Ala 
            20                  25                  30          
Val Ser Tyr Ala Gly Ile Lys Asn Glu Met Cys Lys Asp Arg Ser Met 
        35                  40                  45              
Leu Cys Ala Gly Arg Asp Asp Val Ala Val Thr Asp Arg Asp Ala Lys 
    50                  55                  60                  
Ile Asn Ala Pro Pro Pro Asn Leu His Thr Gly Asp Phe Pro Asn Pro 
65                  70                  75                  80  
Asn Asp Ala Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala 
                85                  90                  95      
Gly Tyr Thr Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu 
            100                 105                 110         
Ser Val Gly Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His 
        115                 120                 125             
Gly Tyr Asn Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu 
    130                 135                 140                 
Ala Pro Glu Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp 
145                 150                 155                 160 
Glu Ala Val Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val 
                165                 170                 175     
Lys Glu Ile Gly His Ile Asp Leu Val Ser His Ile Ile Gly Gly Arg 
            180                 185                 190         
Ser Val Asp Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu 
        195                 200                 205             
His Ile Met Asn Thr Asn Asp Glu Thr Lys Asn Glu Met Met Val Ala 
    210                 215                 220                 
Ala Ile Arg Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile 
225                 230                 235                 240 
Val Asn Asn Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu 
                245                 250                 255     
Phe Gln Ile Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp 
            260                 265                 270         
Tyr Ser Gly Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln 
        275                 280                 285             
Ser Asp Tyr Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu 
    290                 295                 300                 
Phe Ile Phe Ser Thr Gly Asn Asp Ala Gln Ala Gln Pro Asn Thr Tyr 
305                 310                 315                 320 
Ala Leu Leu Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr 
                325                 330                 335     
Val Ala Gly Val Asp Arg Ser Gly Glu Lys Phe Lys Arg Glu Met Tyr 
            340                 345                 350         
Gly Glu Pro Gly Thr Glu Pro Leu Glu Tyr Gly Ser Asn His Cys Gly 
        355                 360                 365             
Ile Thr Ala Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg 
    370                 375                 380                 
Phe Thr Arg Thr Asn Pro Ile Gln Ile Ala Gly Thr Ala Phe Ser Ala 
385                 390                 395                 400 
Pro Ile Val Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp 
                405                 410                 415     
Met Ser Asn Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp 
            420                 425                 430         
Ile Gly Ala Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp 
        435                 440                 445             
Ala Gly Lys Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe 
    450                 455                 460                 
Thr Ala Asp Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn 
465                 470                 475                 480 
Asp Ile Ser Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu 
                485                 490                 495     
Gln Leu His Gly Asn Asn Thr Tyr Thr Gly Lys Thr Ile Ile Glu Gly 
            500                 505                 510         
Gly Ser Leu Val Leu Tyr Gly Asn Asn Lys Ser Asp Met Arg Val Glu 
        515                 520                 525             
Thr Lys Gly Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu 
    530                 535                 540                 
Asn Ser Asp Gly Ile Val Tyr Leu Ala Asp Thr Asp Gln Ser Gly Ala 
545                 550                 555                 560 
Asn Glu Thr Val His Ile Lys Gly Ser Leu Gln Leu Asp Gly Lys Gly 
                565                 570                 575     
Thr Leu Tyr Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala 
            580                 585                 590         
Ile Ile Gly Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly 
        595                 600                 605             
Tyr Leu Asn Ser Thr Gly Arg Arg Val Pro Phe Leu Ser Ala Ala Lys 
    610                 615                 620                 
Ile Gly Gln Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly 
625                 630                 635                 640 
Leu Leu Ala Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly 
                645                 650                 655     
Asp Thr Leu Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala 
            660                 665                 670         
Ser Ala Ala Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu 
        675                 680                 685             
Gln Gly Gly Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser 
    690                 695                 700                 
Glu Ser Ser Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg 
705                 710                 715                 720 
Thr Asp Met Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala 
                725                 730                 735     
Ala Ala Val Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn 
            740                 745                 750         
Ser Leu Ala Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp 
        755                 760                 765             
Met Gln Gly Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn 
    770                 775                 780                 
Gly Thr Gly Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr 
785                 790                 795                 800 
Trp Glu Gln Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr 
                805                 810                 815     
Val Gly Ile Ala Ala Lys Thr Gly Glu Asn Thr Thr Ala Ala Ala Thr 
            820                 825                 830         
Leu Gly Met Gly Arg Ser Thr Trp Ser Glu Asn Ser Ala Asn Ala Lys 
        835                 840                 845             
Thr Asp Ser Ile Ser Leu Phe Ala Gly Ile Arg His Asp Ala Gly Asp 
    850                 855                 860                 
Ile Gly Tyr Leu Lys Gly Leu Phe Ser Tyr Gly Arg Tyr Lys Asn Ser 
865                 870                 875                 880 
Ile Ser Arg Ser Thr Gly Ala Asp Glu His Ala Glu Gly Ser Val Asn 
                885                 890                 895     
Gly Thr Leu Met Gln Leu Gly Ala Leu Gly Gly Val Asn Val Pro Phe 
            900                 905                 910         
Ala Ala Thr Gly Asp Leu Thr Val Glu Gly Gly Leu Arg Tyr Asp Leu 
        915                 920                 925             
Leu Lys Gln Asp Ala Phe Ala Glu Lys Gly Ser Ala Leu Gly Trp Ser 
    930                 935                 940                 
Gly Asn Ser Leu Thr Glu Gly Thr Leu Val Gly Leu Ala Gly Leu Lys 
945                 950                 955                 960 
Leu Ser Gln Pro Leu Ser Asp Lys Ala Val Leu Phe Ala Thr Ala Gly 
                965                 970                 975     
Val Glu Arg Asp Leu Asn Gly Arg Asp Tyr Thr Val Thr Gly Gly Phe 
            980                 985                 990         
Thr Gly Ala Thr Ala Ala Thr Gly Lys Thr Gly Ala Arg Asn Met Pro 
        995                 1000                1005            
His Thr Arg Leu Val Ala Gly Leu Gly Ala Asp Val Glu Phe Gly Asn 
    1010                1015                1020                
Gly Trp Asn Gly Leu Ala Arg Tyr Ser Tyr Ala Gly Ser Lys Gln Tyr 
1025                1030                1035                1040
Gly Asn His Ser Gly Arg Val Gly Val Gly Tyr Arg Phe 
                1045                1050            

<210> 6
<211> 1053
<212> PRT
<213> Neisseria meningitidis


<400> 6
Gly Gly Gly Gly Gly Gly Thr Ser Ala Pro Asp Phe Asn Ala Gly Gly 
1               5                   10                  15      
Thr Gly Ile Gly Ser Asn Ser Arg Ala Thr Thr Ala Lys Ser Ala Ala 
            20                  25                  30          
Val Ser Tyr Ala Gly Ile Lys Asn Glu Met Cys Lys Asp Arg Ser Met 
        35                  40                  45              
Leu Cys Ala Gly Arg Asp Asp Val Ala Val Thr Asp Arg Asp Ala Lys 
    50                  55                  60                  
Ile Asn Ala Pro Pro Pro Asn Leu His Thr Gly Asp Phe Pro Asn Pro 
65                  70                  75                  80  
Asn Asp Ala Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala 
                85                  90                  95      
Gly Tyr Thr Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu 
            100                 105                 110         
Ser Val Gly Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His 
        115                 120                 125             
Gly Tyr Asn Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu 
    130                 135                 140                 
Ala Pro Glu Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp 
145                 150                 155                 160 
Glu Ala Val Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val 
                165                 170                 175     
Lys Glu Ile Gly His Ile Asp Leu Val Ser His Ile Ile Gly Gly Arg 
            180                 185                 190         
Ser Val Asp Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu 
        195                 200                 205             
His Ile Met Asn Thr Asn Asp Glu Thr Lys Asn Glu Met Met Val Ala 
    210                 215                 220                 
Ala Ile Arg Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile 
225                 230                 235                 240 
Val Asn Asn Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu 
                245                 250                 255     
Phe Gln Ile Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp 
            260                 265                 270         
Tyr Ser Gly Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln 
        275                 280                 285             
Ser Asp Tyr Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu 
    290                 295                 300                 
Phe Ile Phe Ser Thr Gly Asn Asp Ala Gln Ala Gln Pro Asn Thr Tyr 
305                 310                 315                 320 
Ala Leu Leu Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr 
                325                 330                 335     
Val Ala Gly Val Asp Arg Ser Gly Glu Lys Phe Lys Arg Glu Met Tyr 
            340                 345                 350         
Gly Glu Pro Gly Thr Glu Pro Leu Glu Tyr Gly Ser Asn His Cys Gly 
        355                 360                 365             
Ile Thr Ala Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg 
    370                 375                 380                 
Phe Thr Arg Thr Asn Pro Ile Gln Ile Ala Gly Thr Ser Phe Ser Ala 
385                 390                 395                 400 
Pro Ile Val Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp 
                405                 410                 415     
Met Ser Asn Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp 
            420                 425                 430         
Ile Gly Ala Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp 
        435                 440                 445             
Ala Gly Lys Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe 
    450                 455                 460                 
Thr Ala Asp Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn 
465                 470                 475                 480 
Asp Ile Ser Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu 
                485                 490                 495     
Gln Leu His Gly Asn Asn Thr Tyr Thr Gly Lys Thr Ile Ile Glu Gly 
            500                 505                 510         
Gly Ser Leu Val Leu Tyr Gly Asn Asn Lys Ser Asp Met Arg Val Glu 
        515                 520                 525             
Thr Lys Gly Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu 
    530                 535                 540                 
Asn Ser Asp Gly Ile Val Tyr Leu Ala Asp Thr Asp Gln Ser Gly Ala 
545                 550                 555                 560 
Asn Glu Thr Val His Ile Lys Gly Ser Leu Gln Leu Asp Gly Lys Gly 
                565                 570                 575     
Thr Leu Tyr Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala 
            580                 585                 590         
Ile Ile Gly Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly 
        595                 600                 605             
Tyr Leu Asn Ser Thr Gly Arg Arg Val Pro Phe Leu Ser Ala Ala Lys 
    610                 615                 620                 
Ile Gly Gln Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly 
625                 630                 635                 640 
Leu Leu Ala Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly 
                645                 650                 655     
Asp Thr Leu Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala 
            660                 665                 670         
Ser Ala Ala Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu 
        675                 680                 685             
Gln Gly Gly Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser 
    690                 695                 700                 
Glu Ser Ser Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg 
705                 710                 715                 720 
Thr Asp Met Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala 
                725                 730                 735     
Ala Ala Val Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn 
            740                 745                 750         
Ser Leu Ala Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp 
        755                 760                 765             
Met Gln Gly Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn 
    770                 775                 780                 
Gly Thr Gly Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr 
785                 790                 795                 800 
Trp Glu Gln Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr 
                805                 810                 815     
Val Gly Ile Ala Ala Lys Thr Gly Glu Asn Thr Thr Ala Ala Ala Thr 
            820                 825                 830         
Leu Gly Met Gly Arg Ser Thr Trp Ser Glu Asn Ser Ala Asn Ala Lys 
        835                 840                 845             
Thr Asp Ser Ile Ser Leu Phe Ala Gly Ile Arg His Asp Ala Gly Asp 
    850                 855                 860                 
Ile Gly Tyr Leu Lys Gly Leu Phe Ser Tyr Gly Arg Tyr Lys Asn Ser 
865                 870                 875                 880 
Ile Ser Arg Ser Thr Gly Ala Asp Glu His Ala Glu Gly Ser Val Asn 
                885                 890                 895     
Gly Thr Leu Met Gln Leu Gly Ala Leu Gly Gly Val Asn Val Pro Phe 
            900                 905                 910         
Ala Ala Thr Gly Asp Leu Thr Val Glu Gly Gly Leu Arg Tyr Asp Leu 
        915                 920                 925             
Leu Lys Gln Asp Ala Phe Ala Glu Lys Gly Ser Ala Leu Gly Trp Ser 
    930                 935                 940                 
Gly Asn Ser Leu Thr Glu Gly Thr Leu Val Gly Leu Ala Gly Leu Lys 
945                 950                 955                 960 
Leu Ser Gln Pro Leu Ser Asp Lys Ala Val Leu Phe Ala Thr Ala Gly 
                965                 970                 975     
Val Glu Arg Asp Leu Asn Gly Arg Asp Tyr Thr Val Thr Gly Gly Phe 
            980                 985                 990         
Thr Gly Ala Thr Ala Ala Thr Gly Lys Thr Gly Ala Arg Asn Met Pro 
        995                 1000                1005            
His Thr Arg Leu Val Ala Gly Leu Gly Ala Asp Val Glu Phe Gly Asn 
    1010                1015                1020                
Gly Trp Asn Gly Leu Ala Arg Tyr Ser Tyr Ala Gly Ser Lys Gln Tyr 
1025                1030                1035                1040
Gly Asn His Ser Gly Arg Val Gly Val Gly Tyr Arg Phe 
                1045                1050            

