                         SEQUENCE LISTING

<110>  REGENERON PHARMACEUTICALS, INC.
 
<120>  NON-HUMAN ANIMALS HAVING AN ENGINEERED ANGPTL8 GENE

<130>  34634PCT (10232WO01)

<150>  62/291,446
<151>  2016-02-04

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  878
<212>  DNA
<213>  Rattus norvegicus

<400>  1
atacccccga gactgtccac catggttgtg cctattctct gcctcctatg ggccatagca       60

acagcagtgc gacctgcccc agtggcccct ctcggtggtc cagagccggc ccaatatgaa      120

gagttgaccc tgctctttca cggggcccta cagctaggtc aggccctcaa tggtgtgtac      180

aaagccacgg aagctcgcct gacagaagct gggcgcaacc tgggcctttt tgaccaagca      240

ctggaatttc tgggaagaga ggtcaatcag ggccgggatg caacacggga gcttcgcacc      300

agcttgtcgg agattcaggc agaagaggac actttacacc ttcgagcaga agccacagcc      360

cgatcgctga gggaagtggc ccgggcccag catgctctgc ggaacagtgt acggagacta      420

caagtgcagc tgagaggtgc ctggctaggc caagcccacc aagaatttga gaatttaaag      480

gatcgagccg ataagcagaa ccacctcttg tgggctctca ctggccacgt gcagcgacag      540

cagcgtgaga tggcagagca gcaacagtgg ctgcggcaga tccagcagag actccacatg      600

gcagccctcc cagcctgaga ctacctggat gccactgagg accagttgtg ctgcagggaa      660

cactgaatgc gctccaccgg gcctatctat gagcagggcc gacagagctg gctgcccatc      720

agctagactt ggccggtgca ccccgcttcc tggcagagca gagacagaag caagcaggcg      780

ggatggaagg cagaagacag ccccgtggag aaggctggag aaggacatga gctcccttat      840

gccccacacc ccacaataaa aaagaggcaa tctataaa                              878


<210>  2
<211>  198
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Val Val Pro Ile Leu Cys Leu Leu Trp Ala Ile Ala Thr Ala Val 
1               5                   10                  15      


Arg Pro Ala Pro Val Ala Pro Leu Gly Gly Pro Glu Pro Ala Gln Tyr 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Ala Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Lys Ala Thr Glu Ala Arg Leu Thr Glu Ala Gly 
    50                  55                  60                  


Arg Asn Leu Gly Leu Phe Asp Gln Ala Leu Glu Phe Leu Gly Arg Glu 
65                  70                  75                  80  


Val Asn Gln Gly Arg Asp Ala Thr Arg Glu Leu Arg Thr Ser Leu Ser 
                85                  90                  95      


Glu Ile Gln Ala Glu Glu Asp Thr Leu His Leu Arg Ala Glu Ala Thr 
            100                 105                 110         


Ala Arg Ser Leu Arg Glu Val Ala Arg Ala Gln His Ala Leu Arg Asn 
        115                 120                 125             


Ser Val Arg Arg Leu Gln Val Gln Leu Arg Gly Ala Trp Leu Gly Gln 
    130                 135                 140                 


Ala His Gln Glu Phe Glu Asn Leu Lys Asp Arg Ala Asp Lys Gln Asn 
145                 150                 155                 160 


His Leu Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Gln Arg Glu 
                165                 170                 175     


Met Ala Glu Gln Gln Gln Trp Leu Arg Gln Ile Gln Gln Arg Leu His 
            180                 185                 190         


Met Ala Ala Leu Pro Ala 
        195             


<210>  3
<211>  887
<212>  DNA
<213>  Mus musculus

<400>  3
tgtcagccat ggctgtgctt gctctctgcc tcctgtggac cttagcatca gcagtgcgac       60

ccgctccagt ggcccctctg ggtggtccag agccagctca atatgaagag ctgaccctgc      120

tctttcacgg ggccctgcag ctaggccagg ccctcaatgg cgtgtacaga gccacagagg      180

ctcgcctgac agaagctggg cacagcctgg gcctctatga cagagcactg gaattcctgg      240

ggacagaagt caggcagggc caggatgcca cacaggagct tcgcaccagc ctgtcggaga      300

ttcaggtgga agaggacgct ttacaccttc gagctgaagc cacagcccga tcactggggg      360

aagtggcccg ggcccagcag gctctgcggg acactgtacg gagactacaa gtgcagctga      420

gaggcgcctg gctcggtcaa gcccaccaag aatttgagac cttaaaggct cgagctgata      480

agcagagcca cctcttatgg gctctcactg gccacgtgca gcgacagcag cgggagatgg      540

cagagcagca acagtggctg cgacagatcc agcagagact ccacacagca gccctcccag      600

cctgagacta cctggatgcc accgaggacc agttgtgctg caaggaacac tgaagcgctc      660

caccaggccc atgaacaggg ctgacagagc cggctgccca tcagctggac ctggccagtg      720

caccccgctt cctggcagag cggagacaga agcaagcagg cgggatggaa ggcagaagac      780

agagccctgt ggaggagggc tggaaaaaga cacgagcccc cttatgccca cacaccccac      840

aataaaagag aacagaggca atctaaaaaa aaaaaaaaaa aaaaaaa                    887


<210>  4
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Val Leu Ala Leu Cys Leu Leu Trp Thr Leu Ala Ser Ala Val 
1               5                   10                  15      


Arg Pro Ala Pro Val Ala Pro Leu Gly Gly Pro Glu Pro Ala Gln Tyr 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Ala Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Ala Thr Glu Ala Arg Leu Thr Glu Ala Gly 
    50                  55                  60                  


His Ser Leu Gly Leu Tyr Asp Arg Ala Leu Glu Phe Leu Gly Thr Glu 
65                  70                  75                  80  


Val Arg Gln Gly Gln Asp Ala Thr Gln Glu Leu Arg Thr Ser Leu Ser 
                85                  90                  95      


Glu Ile Gln Val Glu Glu Asp Ala Leu His Leu Arg Ala Glu Ala Thr 
            100                 105                 110         


Ala Arg Ser Leu Gly Glu Val Ala Arg Ala Gln Gln Ala Leu Arg Asp 
        115                 120                 125             


Thr Val Arg Arg Leu Gln Val Gln Leu Arg Gly Ala Trp Leu Gly Gln 
    130                 135                 140                 


Ala His Gln Glu Phe Glu Thr Leu Lys Ala Arg Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Leu Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Gln Arg Glu 
                165                 170                 175     


Met Ala Glu Gln Gln Gln Trp Leu Arg Gln Ile Gln Gln Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  5
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  5
ataccttaga ccctcagtca tgccagtgcc tgctctgtgc ctgctctggg ccctggcaat       60

ggtgacccgg cctgcctcag cggcccccat gggcggccca gaactggcac agcatgagga      120

gctgaccctg ctcttccatg ggaccctgca gctgggccag gccctcaacg gtgtgtacag      180

gaccacggag ggacggctga caaaggccag gaacagcctg ggtctctatg gccgcacaat      240

agaactcctg gggcaggagg tcagccgggg ccgggatgca gcccaggaac ttcgggcaag      300

cctgttggag actcagatgg aggaggatat tctgcagctg caggcagagg ccacagctga      360

ggtgctgggg gaggtggccc aggcacagaa ggtgctacgg gacagcgtgc agcggctaga      420

agtccagctg aggagcgcct ggctgggccc tgcctaccga gaatttgagg tcttaaaggc      480

tcacgctgac aagcagagcc acatcctatg ggccctcaca ggccacgtgc agcggcagag      540

gcgggagatg gtggcacagc agcatcggct gcgacagatc caggagagac tccacacagc      600

ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct gcaaggaaca      660

cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg ggatcagcca      720

gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg gacaaaggca      780

gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc atgcctacac      840

acccctcatt aaagcagagt cgtggcatct caaaaaaaaa aaaaaaaa                   888


<210>  6
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  7
<211>  877
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Engineered Angpt18 polynucleotide

<400>  7
tgtcagccat gccagtgcct gctctgtgcc tgctctgggc cctggcaatg gtgacccggc       60

ctgcctcagc ggcccccatg ggcggcccag aactggcaca gcatgaggag ctgaccctgc      120

tcttccatgg gaccctgcag ctgggccagg ccctcaacgg tgtgtacagg accacggagg      180

gacggctgac aaaggccagg aacagcctgg gtctctatgg ccgcacaata gaactcctgg      240

ggcaggaggt cagccggggc cgggatgcag cccaggaact tcgggcaagc ctgttggaga      300

ctcagatgga ggaggatatt ctgcagctgc aggcagaggc cacagctgag gtgctggggg      360

aggtggccca ggcacagaag gtgctacggg acagcgtgca gcggctagaa gtccagctga      420

ggagcgcctg gctgggccct gcctaccgag aatttgaggt cttaaaggct cacgctgaca      480

agcagagcca catcctatgg gccctcacag gccacgtgca gcggcagagg cgggagatgg      540

tggcacagca gcatcggctg cgacagatcc aggagagact ccacacagcg gcgctcccag      600

cctgaatctg cctggatgga actgaggacc aatcatgctg caaggaacac ttccacgccc      660

cgtgaggccc ctgtgcaggg aggagctgcc tgttcactgg gatcagccag ggcgccgggc      720

cccacttctg agcacagagc agagacagac gcaggcgggg acaaaggcag aggatgtagc      780

cccattgggg aggggtggag gaaggacatg taccctttca tgcctacaca cccctcatta      840

aagcagagtc gtggcatctc aaaaaaaaaa aaaaaaa                               877


<210>  8
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Engineered Angpt18 polypeptide

<400>  8

Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  9
<211>  2383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary synthetic DNA fragment for engineering a non-human 
       Angpt18 gene

<400>  9
ccagtgcctg ctctgtgcct gctctgggcc ctggcaatgg tgacccggcc tgcctcagcg       60

gcccccatgg gcggcccaga actggcacag catgaggagc tgaccctgct cttccatggg      120

accctgcagc tgggccaggc cctcaacggt gtgtacagga ccacggaggg acggctgaca      180

aaggccagga acagcctggg tctctatggc cgcacaatag aactcctggg gcaggaggtc      240

agccggggcc gggatgcagc ccaggaactt cgggcaagcc tgttggagac tcaggtgggc      300

accgtagctg cgacactgtg gggtggccag gagtccaaag aggagttcgt gtctagggta      360

accaaccatc ctggtttgcc caggactgaa gggattcctg ggatacaaga ttttcagcga      420

taaactcagg caagtcctta ggtacacaaa gatgagttgg acatcctact agtgacccac      480

tgtttattaa gcagatggag gaggatattc tgcagctgca ggcagaggcc acagctgagg      540

tgctggggga ggtggcccag gcacagaagg tgctacggga cagcgtgcag cggctagaag      600

tccagctgag gagcgcctgg ctgggccctg cctaccgaga atttgaggtc ttaaaggtaa      660

ggagctcccc caaccctagt gggctgagac cctgatttcc ggccagaact cgcttctgca      720

ccttgagtcc caaagacctc ccagatcagc ctcccagctc tgtggcctct accctgcatg      780

tccccagaca aaactcaagt ccttttgtgt gcctcagttt cccttttgtg tgcctcagtt      840

gcaaataagg gcaacacctg atatctcaca gtagggccag gtactcaatg caggtaaaat      900

attcagcatg gggcgggcac acagttggtg ctcaataaat tctttttttt tttttttttg      960

agacagagtc tcactgttgc ccaggctgga gtgcagtggt gtgatcttgg ctcactgcaa     1020

cctccacctc ctaggttcaa gtgattctcc tgcctcagcc tcctgagtag ctggaattac     1080

aggtgcacca gctaattttt gtatttttta gtagagatgg gatttcacca tgttggccag     1140

gctggtctcg aactcctgac ctcaagggat ctgcctgcct cggtttccca aagtgctggg     1200

attacaggtg tgagccacta cacctggcca ataaattctt actactagag aaactggtaa     1260

cattttgtga gcacccagta agtacccagc actgttctat gccctttaat aatccatatg     1320

atggccgggc atggtggctc atgcctgtaa tcccagcact ttgggtagct aaggtgggtg     1380

gaacacttaa ggtcaggagt tcgagaccac cctggccaac atggtgaaac cccgtctcta     1440

ctaaaaatac aaaaaattag ctgggcgtgg tggcacatgc ctgtagtccc agctactcag     1500

gaggcttagg taggagaatc gcttgaacct gggaggtgga ggttgcagtg agctgagatc     1560

gtgtcattgc actcagcctg ggtgacagag agagactcaa aaaaaaaaaa aaatccatag     1620

gatgttcatc acctccccat gaagtgagtc ctattttatc cccattttac agatggggaa     1680

actgaggcca aagagcattg ttgacttgct gggtcacaca gatacaatga ggggctgggg     1740

cagagggtca ggggatggga ggtgaggtgg ctgtcggctg aggtttccat tctgaccccc     1800

acaggctcac gctgacaagc agagccacat cctatgggcc ctcacaggcc acgtgcagcg     1860

gcagaggcgg gagatggtgg cacagcagca tcggctgcga cagatccagg agaggtgagc     1920

ctggcagggg tttggcaggc agggcagttg gatggggggc gcacagggca gctggaaagg     1980

ggccccctca cctgggctga gccacatctc cctccccaga ctccacacag cggcgctccc     2040

agcctgaatc tgcctggatg gaactgagga ccaatcatgc tgcaaggaac acttccacgc     2100

cccgtgaggc ccctgtgcag ggaggagctg cctgttcact gggatcagcc agggcgccgg     2160

gccccacttc tgagcacaga gcagagacag acgcaggcgg ggacaaaggc agaggatgta     2220

gccccattgg ggaggggtgg aggaaggaca tgtacccttt catgcctaca cacccctcat     2280

taaagcagag tcgtggcatc tcacccaggg tgtctgtgtg tgtccttggc ttagggagac     2340

cccacccagc atgatgtatg aatacctccc attcaagtgc cca                       2383


<210>  10
<211>  7473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary engineered Angptl8 allele including a selection 
       cassette

<400>  10
cacgaaactg tcagccatgc cagtgcctgc tctgtgcctg ctctgggccc tggcaatggt       60

gacccggcct gcctcagcgg cccccatggg cggcccagaa ctggcacagc atgaggagct      120

gaccctgctc ttccatggga ccctgcagct gggccaggcc ctcaacggtg tgtacaggac      180

cacggaggga cggctgacaa aggccaggaa cagcctgggt ctctatggcc gcacaataga      240

actcctgggg caggaggtca gccggggccg ggatgcagcc caggaacttc gggcaagcct      300

gttggagact caggtgggca ccgtagctgc gacactgtgg ggtggccagg agtccaaaga      360

ggagttcgtg tctagggtaa ccaaccatcc tggtttgccc aggactgaag ggattcctgg      420

gatacaagat tttcagcgat aaactcaggc aagtccttag gtacacaaag atgagttgga      480

catcctacta gtgacccact gtttattaag cagatggagg aggatattct gcagctgcag      540

gcagaggcca cagctgaggt gctgggggag gtggcccagg cacagaaggt gctacgggac      600

agcgtgcagc ggctagaagt ccagctgagg agcgcctggc tgggccctgc ctaccgagaa      660

tttgaggtct taaaggtaag gagctccccc aaccctagtg ggctgagacc ctgatttccg      720

gccagaactc gcttctgcac cttgagtccc aaagacctcc cagatcagcc tcccagctct      780

gtggcctcta ccctgcatgt ccccagacaa aactcaagtc cttttgtgtg cctcagtttc      840

ccttttgtgt gcctcagttg caaataaggg caacacctga tatctcacag tagggccagg      900

tactcaatgc aggtaaaata ttcagcatgg ggcgggcaca cagttggtgc tcaataaatt      960

cttttttttt ttttttttga gacagagtct cactgttgcc caggctggag tgcagtggtg     1020

tgatcttggc tcactgcaac ctccacctcc taggttcaag tgattctcct gcctcagcct     1080

cctgagtagc tggaattaca ggtgcaccag ctaatttttg tattttttag tagagatggg     1140

atttcaccat gttggccagg ctggtctcga actcctgacc tcaagggatc tgcctgcctc     1200

ggtttcccaa agtgctggga ttacaggtgt gagccactac acctggccaa taaattctta     1260

ctactagaga aactggtaac attttgtgag cacccagtaa gtacccagca ctgttctatg     1320

ccctttaata atccatatga tggccgggca tggtggctca tgcctgtaat cccagcactt     1380

tgggtagcta aggtgggtgg aacacttaag gtcaggagtt cgagaccacc ctggccaaca     1440

tggtgaaacc ccgtctctac taaaaataca aaaaattagc tgggcgtggt ggcacatgcc     1500

tgtagtccca gctactcagg aggcttaggt aggagaatcg cttgaacctg ggaggtggag     1560

gttgcagtga gctgagatcg tgtcattgca ctcagcctgg gtgacagaga gagactcaaa     1620

aaaaaaaaaa aatccatagg atgttcatca cctccccatg aagtgagtcc tattttatcc     1680

ccattttaca gatggggaaa ctgaggccaa agagcattgt tgacttgctg ggtcacacag     1740

atacaatgag gggctggggc agagggtcag gggatgggag gtgaggtggc tgtcggctga     1800

ggtttccatt ctgaccccca caggctcacg ctgacaagca gagccacatc ctatgggccc     1860

tcacaggcca cgtgcagcgg cagaggcggg agatggtggc acagcagcat cggctgcgac     1920

agatccagga gaggtgagcc tggcaggggt ttggcaggca gggcagttgg atggggggcg     1980

cacagggcag ctggaaaggg gccccctcac ctgggctgag ccacatctcc ctccccagac     2040

tccacacagc ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct     2100

gcaaggaaca cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg     2160

ggatcagcca gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg     2220

gacaaaggca gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc     2280

atgcctacac acccctcatt aaagcagagt cgtggcatct cacccagggt gtctgtgtgt     2340

gtccttggct tagggagacc ccacccagca tgatgtatga atacctccca ttcaagtgcc     2400

cactcgagat aacttcgtat aatgtatgct atacgaagtt atatgcatgg cctccgcgcc     2460

gggttttggc gcctcccgcg ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg     2520

aagggcgcag cgagcgtcct gatccttccg cccggacgct caggacagcg gcccgctgct     2580

cataagactc ggccttagaa ccccagtatc agcagaagga cattttagga cgggacttgg     2640

gtgactctag ggcactggtt ttctttccag agagcggaac aggcgaggaa aagtagtccc     2700

ttctcggcga ttctgcggag ggatctccgt ggggcggtga acgccgatga ttatataagg     2760

acgcgccggg tgtggcacag ctagttccgt cgcagccggg atttgggtcg cggttcttgt     2820

ttgtggatcg ctgtgatcgt cacttggtga gtagcgggct gctgggctgg ccggggcttt     2880

cgtggccgcc gggccgctcg gtgggacgga agcgtgtgga gagaccgcca agggctgtag     2940

tctgggtccg cgagcaaggt tgccctgaac tgggggttgg ggggagcgca gcaaaatggc     3000

ggctgttccc gagtcttgaa tggaagacgc ttgtgaggcg ggctgtgagg tcgttgaaac     3060

aaggtggggg gcatggtggg cggcaagaac ccaaggtctt gaggccttcg ctaatgcggg     3120

aaagctctta ttcgggtgag atgggctggg gcaccatctg gggaccctga cgtgaagttt     3180

gtcactgact ggagaactcg gtttgtcgtc tgttgcgggg gcggcagtta tggcggtgcc     3240

gttgggcagt gcacccgtac ctttgggagc gcgcgccctc gtcgtgtcgt gacgtcaccc     3300

gttctgttgg cttataatgc agggtggggc cacctgccgg taggtgtgcg gtaggctttt     3360

ctccgtcgca ggacgcaggg ttcgggccta gggtaggctc tcctgaatcg acaggcgccg     3420

gacctctggt gaggggaggg ataagtgagg cgtcagtttc tttggtcggt tttatgtacc     3480

tatcttctta agtagctgaa gctccggttt tgaactatgc gctcggggtt ggcgagtgtg     3540

ttttgtgaag ttttttaggc accttttgaa atgtaatcat ttgggtcaat atgtaatttt     3600

cagtgttaga ctagtaaatt gtccgctaaa ttctggccgt ttttggcttt tttgttagac     3660

gtgttgacaa ttaatcatcg gcatagtata tcggcatagt ataatacgac aaggtgagga     3720

actaaaccat gggatcggcc attgaacaag atggattgca cgcaggttct ccggccgctt     3780

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     3840

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     3900

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg     3960

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     4020

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     4080

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     4140

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     4200

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     4260

aggcgcgcat gcccgacggc gatgatctcg tcgtgaccca tggcgatgcc tgcttgccga     4320

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     4380

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     4440

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     4500

ccttctatcg ccttcttgac gagttcttct gaggggatcc gctgtaagtc tgcagaaatt     4560

gatgatctat taaacaataa agatgtccac taaaatggaa gtttttcctg tcatactttg     4620

ttaagaaggg tgagaacaga gtacctacat tttgaatgga aggattggag ctacgggggt     4680

gggggtgggg tgggattaga taaatgcctg ctctttactg aaggctcttt actattgctt     4740

tatgataatg tttcatagtt ggatatcata atttaaacaa gcaaaaccaa attaagggcc     4800

agctcattcc tcccactcat gatctataga tctatagatc tctcgtggga tcattgtttt     4860

tctcttgatt cccactttgt ggttctaagt actgtggttt ccaaatgtgt cagtttcata     4920

gcctgaagaa cgagatcagc agcctctgtt ccacatacac ttcattctca gtattgtttt     4980

gccaagttct aattccatca gacctcgacc tgcagcccct agcccgggcg ccagtagcag     5040

cacccacgtc caccttctgt ctagtaatgt ccaacacctc cctcagtcca aacactgctc     5100

tgcatccatg tggctcccat ttatacctga agcacttgat ggggcctcaa tgttttacta     5160

gagcccaccc ccctgcaact ctgagaccct ctggatttgt ctgtcagtgc ctcactgggg     5220

cgttggataa tttcttaaaa ggtcaagttc cctcagcagc attctctgag cagtctgaag     5280

atgtgtgctt ttcacagttc aaatccatgt ggctgtttca cccacctgcc tggccttggg     5340

ttatctatca ggacctagcc tagaagcagg tgtgtggcac ttaacaccta agctgagtga     5400

ctaactgaac actcaagtgg atgccatctt tgtcacttct tgactgtgac acaagcaact     5460

cctgatgcca aagccctgcc cacccctctc atgcccatat ttggacatgg tacaggtcct     5520

cactggccat ggtctgtgag gtcctggtcc tctttgactt cataattcct aggggccact     5580

agtatctata agaggaagag ggtgctggct cccaggccac agcccacaaa attccacctg     5640

ctcacaggtt ggctggctcg acccaggtgg tgtcccctgc tctgagccag ctcccggcca     5700

agccagcacc atgggtaccc ccaagaagaa gaggaaggtg cgtaccgatt taaattccaa     5760

tttactgacc gtacaccaaa atttgcctgc attaccggtc gatgcaacga gtgatgaggt     5820

tcgcaagaac ctgatggaca tgttcaggga tcgccaggcg ttttctgagc atacctggaa     5880

aatgcttctg tccgtttgcc ggtcgtgggc ggcatggtgc aagttgaata accggaaatg     5940

gtttcccgca gaacctgaag atgttcgcga ttatcttcta tatcttcagg cgcgcggtct     6000

ggcagtaaaa actatccagc aacatttggg ccagctaaac atgcttcatc gtcggtccgg     6060

gctgccacga ccaagtgaca gcaatgctgt ttcactggtt atgcggcgga tccgaaaaga     6120

aaacgttgat gccggtgaac gtgcaaaaca ggctctagcg ttcgaacgca ctgatttcga     6180

ccaggttcgt tcactcatgg aaaatagtga tcgctgccag gatatacgta atctggcatt     6240

tctggggatt gcttataaca ccctgttacg tatagccgaa attgccagga tcagggttaa     6300

agatatctca cgtactgacg gtgggagaat gttaatccat attggcagaa cgaaaacgct     6360

ggttagcacc gcaggtgtag agaaggcact tagcctgggg gtaactaaac tggtcgagcg     6420

atggatttcc gtctctggtg tagctgatga tccgaataac tacctgtttt gccgggtcag     6480

aaaaaatggt gttgccgcgc catctgccac cagccagcta tcaactcgcg ccctggaagg     6540

gatttttgaa gcaactcatc gattgattta cggcgctaag gtaaatataa aatttttaag     6600

tgtataatgt gttaaactac tgattctaat tgtttgtgta ttttaggatg actctggtca     6660

gagatacctg gcctggtctg gacacagtgc ccgtgtcgga gccgcgcgag atatggcccg     6720

cgctggagtt tcaataccgg agatcatgca agctggtggc tggaccaatg taaatattgt     6780

catgaactat atccgtaacc tggatagtga aacaggggca atggtgcgcc tgctggaaga     6840

tggcgattga tctagataag taatgatcat aatcagccat atcacatctg tagaggtttt     6900

acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat     6960

tgttgttgtt aaacctgccc tagttgcggc caattccagc tgagcgtgcc tccgcaccat     7020

taccagttgg tctggtgtca aaaataataa taaccgggca ggggggatct aagctctaga     7080

taagtaatga tcataatcag ccatatcaca tctgtagagg ttttacttgc tttaaaaaac     7140

ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg     7200

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     7260

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     7320

gtctggaata acttcgtata atgtatgcta tacgaagtta tgctagtaac tataacggtc     7380

ctaaggtagc gagctagcga tgccaccgag gaccagttgt gctgcaagga acactgaagc     7440

gctccaccag gcccatgaac agggctgaca gag                                  7473


<210>  11
<211>  2554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary engineered Angptl8 allele after recombinase-mediated 
       excision of a selection cassette

<400>  11
cacgaaactg tcagccatgc cagtgcctgc tctgtgcctg ctctgggccc tggcaatggt       60

gacccggcct gcctcagcgg cccccatggg cggcccagaa ctggcacagc atgaggagct      120

gaccctgctc ttccatggga ccctgcagct gggccaggcc ctcaacggtg tgtacaggac      180

cacggaggga cggctgacaa aggccaggaa cagcctgggt ctctatggcc gcacaataga      240

actcctgggg caggaggtca gccggggccg ggatgcagcc caggaacttc gggcaagcct      300

gttggagact caggtgggca ccgtagctgc gacactgtgg ggtggccagg agtccaaaga      360

ggagttcgtg tctagggtaa ccaaccatcc tggtttgccc aggactgaag ggattcctgg      420

gatacaagat tttcagcgat aaactcaggc aagtccttag gtacacaaag atgagttgga      480

catcctacta gtgacccact gtttattaag cagatggagg aggatattct gcagctgcag      540

gcagaggcca cagctgaggt gctgggggag gtggcccagg cacagaaggt gctacgggac      600

agcgtgcagc ggctagaagt ccagctgagg agcgcctggc tgggccctgc ctaccgagaa      660

tttgaggtct taaaggtaag gagctccccc aaccctagtg ggctgagacc ctgatttccg      720

gccagaactc gcttctgcac cttgagtccc aaagacctcc cagatcagcc tcccagctct      780

gtggcctcta ccctgcatgt ccccagacaa aactcaagtc cttttgtgtg cctcagtttc      840

ccttttgtgt gcctcagttg caaataaggg caacacctga tatctcacag tagggccagg      900

tactcaatgc aggtaaaata ttcagcatgg ggcgggcaca cagttggtgc tcaataaatt      960

cttttttttt ttttttttga gacagagtct cactgttgcc caggctggag tgcagtggtg     1020

tgatcttggc tcactgcaac ctccacctcc taggttcaag tgattctcct gcctcagcct     1080

cctgagtagc tggaattaca ggtgcaccag ctaatttttg tattttttag tagagatggg     1140

atttcaccat gttggccagg ctggtctcga actcctgacc tcaagggatc tgcctgcctc     1200

ggtttcccaa agtgctggga ttacaggtgt gagccactac acctggccaa taaattctta     1260

ctactagaga aactggtaac attttgtgag cacccagtaa gtacccagca ctgttctatg     1320

ccctttaata atccatatga tggccgggca tggtggctca tgcctgtaat cccagcactt     1380

tgggtagcta aggtgggtgg aacacttaag gtcaggagtt cgagaccacc ctggccaaca     1440

tggtgaaacc ccgtctctac taaaaataca aaaaattagc tgggcgtggt ggcacatgcc     1500

tgtagtccca gctactcagg aggcttaggt aggagaatcg cttgaacctg ggaggtggag     1560

gttgcagtga gctgagatcg tgtcattgca ctcagcctgg gtgacagaga gagactcaaa     1620

aaaaaaaaaa aatccatagg atgttcatca cctccccatg aagtgagtcc tattttatcc     1680

ccattttaca gatggggaaa ctgaggccaa agagcattgt tgacttgctg ggtcacacag     1740

atacaatgag gggctggggc agagggtcag gggatgggag gtgaggtggc tgtcggctga     1800

ggtttccatt ctgaccccca caggctcacg ctgacaagca gagccacatc ctatgggccc     1860

tcacaggcca cgtgcagcgg cagaggcggg agatggtggc acagcagcat cggctgcgac     1920

agatccagga gaggtgagcc tggcaggggt ttggcaggca gggcagttgg atggggggcg     1980

cacagggcag ctggaaaggg gccccctcac ctgggctgag ccacatctcc ctccccagac     2040

tccacacagc ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct     2100

gcaaggaaca cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg     2160

ggatcagcca gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg     2220

gacaaaggca gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc     2280

atgcctacac acccctcatt aaagcagagt cgtggcatct cacccagggt gtctgtgtgt     2340

gtccttggct tagggagacc ccacccagca tgatgtatga atacctccca ttcaagtgcc     2400

cactcgagat aacttcgtat aatgtatgct atacgaagtt atgctagtaa ctataacggt     2460

cctaaggtag cgagctagcg atgccaccga ggaccagttg tgctgcaagg aacactgaag     2520

cgctccacca ggcccatgaa cagggctgac agag                                 2554


<210>  12
<211>  680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protamine 1 (Prm1) promoter

<400>  12
ccagtagcag cacccacgtc caccttctgt ctagtaatgt ccaacacctc cctcagtcca       60

aacactgctc tgcatccatg tggctcccat ttatacctga agcacttgat ggggcctcaa      120

tgttttacta gagcccaccc ccctgcaact ctgagaccct ctggatttgt ctgtcagtgc      180

ctcactgggg cgttggataa tttcttaaaa ggtcaagttc cctcagcagc attctctgag      240

cagtctgaag atgtgtgctt ttcacagttc aaatccatgt ggctgtttca cccacctgcc      300

tggccttggg ttatctatca ggacctagcc tagaagcagg tgtgtggcac ttaacaccta      360

agctgagtga ctaactgaac actcaagtgg atgccatctt tgtcacttct tgactgtgac      420

acaagcaact cctgatgcca aagccctgcc cacccctctc atgcccatat ttggacatgg      480

tacaggtcct cactggccat ggtctgtgag gtcctggtcc tctttgactt cataattcct      540

aggggccact agtatctata agaggaagag ggtgctggct cccaggccac agcccacaaa      600

attccacctg ctcacaggtt ggctggctcg acccaggtgg tgtcccctgc tctgagccag      660

ctcccggcca agccagcacc                                                  680


<210>  13
<211>  1052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Blimp1 promoter 1kb

<400>  13
tgccatcatc acaggatgtc cttccttctc cagaagacag actggggctg aaggaaaagc       60

cggccaggct cagaacgagc cccactaatt actgcctcca acagctttcc actcactgcc      120

cccagcccaa catccccttt ttaactggga agcattccta ctctccattg tacgcacacg      180

ctcggaagcc tggctgtggg tttgggcatg agaggcaggg acaacaaaac cagtatatat      240

gattataact ttttcctgtt tccctatttc caaatggtcg aaaggaggaa gttaggtcta      300

cctaagctga atgtattcag ttagcaggag aaatgaaatc ctatacgttt aatactagag      360

gagaaccgcc ttagaatatt tatttcattg gcaatgactc caggactaca cagcgaaatt      420

gtattgcatg tgctgccaaa atactttagc tctttccttc gaagtacgtc ggatcctgta      480

attgagacac cgagtttagg tgactagggt tttcttttga ggaggagtcc cccaccccgc      540

cccgctctgc cgcgacagga agctagcgat ccggaggact tagaatacaa tcgtagtgtg      600

ggtaaacatg gagggcaagc gcctgcaaag ggaagtaaga agattcccag tccttgttga      660

aatccatttg caaacagagg aagctgccgc gggtcgcagt cggtgggggg aagccctgaa      720

ccccacgctg cacggctggg ctggccaggt gcggccacgc ccccatcgcg gcggctggta      780

ggagtgaatc agaccgtcag tattggtaaa gaagtctgcg gcagggcagg gagggggaag      840

agtagtcagt cgctcgctca ctcgctcgct cgcacagaca ctgctgcagt gacactcggc      900

cctccagtgt cgcggagacg caagagcagc gcgcagcacc tgtccgcccg gagcgagccc      960

ggcccgcggc cgtagaaaag gagggaccgc cgaggtgcgc gtcagtactg ctcagcccgg     1020

cagggacgcg ggaggatgtg gactgggtgg ac                                   1052


<210>  14
<211>  2008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Blimp1 promoter 2kb

<400>  14
gtggtgctga ctcagcatcg gttaataaac cctctgcagg aggctggatt tcttttgttt       60

aattatcact tggacctttc tgagaactct taagaattgt tcattcgggt ttttttgttt      120

tgttttggtt tggttttttt gggttttttt tttttttttt tttttggttt ttggagacag      180

ggtttctctg tatatagccc tggcacaaga gcaagctaac agcctgtttc ttcttggtgc      240

tagcgccccc tctggcagaa aatgaaataa caggtggacc tacaaccccc cccccccccc      300

ccagtgtatt ctactcttgt ccccggtata aatttgattg ttccgaacta cataaattgt      360

agaaggattt tttagatgca catatcattt tctgtgatac cttccacaca cccctccccc      420

ccaaaaaaat ttttctggga aagtttcttg aaaggaaaac agaagaacaa gcctgtcttt      480

atgattgagt tgggcttttg ttttgctgtg tttcatttct tcctgtaaac aaatactcaa      540

atgtccactt cattgtatga ctaagttggt atcattaggt tgggtctggg tgtgtgaatg      600

tgggtgtgga tctggatgtg ggtgggtgtg tatgccccgt gtgtttagaa tactagaaaa      660

gataccacat cgtaaacttt tgggagagat gatttttaaa aatgggggtg ggggtgaggg      720

gaacctgcga tgaggcaagc aagataaggg gaagacttga gtttctgtga tctaaaaagt      780

cgctgtgatg ggatgctggc tataaatggg cccttagcag cattgtttct gtgaattgga      840

ggatccctgc tgaaggcaaa agaccattga aggaagtacc gcatctggtt tgttttgtaa      900

tgagaagcag gaatgcaagg tccacgctct taataataaa caaacaggac attgtatgcc      960

atcatcacag gatgtccttc cttctccaga agacagactg gggctgaagg aaaagccggc     1020

caggctcaga acgagcccca ctaattactg cctccaacag ctttccactc actgccccca     1080

gcccaacatc ccctttttaa ctgggaagca ttcctactct ccattgtacg cacacgctcg     1140

gaagcctggc tgtgggtttg ggcatgagag gcagggacaa caaaaccagt atatatgatt     1200

ataacttttt cctgtttccc tatttccaaa tggtcgaaag gaggaagtta ggtctaccta     1260

agctgaatgt attcagttag caggagaaat gaaatcctat acgtttaata ctagaggaga     1320

accgccttag aatatttatt tcattggcaa tgactccagg actacacagc gaaattgtat     1380

tgcatgtgct gccaaaatac tttagctctt tccttcgaag tacgtcggat cctgtaattg     1440

agacaccgag tttaggtgac tagggttttc ttttgaggag gagtccccca ccccgccccg     1500

ctctgccgcg acaggaagct agcgatccgg aggacttaga atacaatcgt agtgtgggta     1560

aacatggagg gcaagcgcct gcaaagggaa gtaagaagat tcccagtcct tgttgaaatc     1620

catttgcaaa cagaggaagc tgccgcgggt cgcagtcggt ggggggaagc cctgaacccc     1680

acgctgcacg gctgggctgg ccaggtgcgg ccacgccccc atcgcggcgg ctggtaggag     1740

tgaatcagac cgtcagtatt ggtaaagaag tctgcggcag ggcagggagg gggaagagta     1800

gtcagtcgct cgctcactcg ctcgctcgca cagacactgc tgcagtgaca ctcggccctc     1860

cagtgtcgcg gagacgcaag agcagcgcgc agcacctgtc cgcccggagc gagcccggcc     1920

cgcggccgta gaaaaggagg gaccgccgag gtgcgcgtca gtactgctca gcccggcagg     1980

gacgcgggag gatgtggact gggtggac                                        2008


<210>  15
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
aaggcagccg cagcggcccg ggaaccacac ccacgaaact gtcagccatg ccagtgcctg       60

ctctgtgcct gctctgggcc ctggcaatgg tgacccggcc                            100


<210>  16
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
gggagacccc acccagcatg atgtatgaat acctcccatt caagtgccca ctcgagataa       60

cttcgtataa tgtatgctat acgaagttat atgcatggcc tccgcgccgg gttttggcgc      120

ctcccgcggg cgcccccctc ctcacggcga                                       150


<210>  17
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagt aactataacg gtcctaaggt      120

agcgagctag cgatgccacc gaggaccagt tgtgctgcaa ggaacactga agcgctccac      180

c                                                                      181


<210>  18
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gggagacccc acccagcatg atgtatgaat acctcccatt caagtgccca gtcgagataa       60

cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc taaggtagcg      120

agctagcgat gccaccgagg accagttgtg ctgcaaggaa cactgaagcg ctccacc         177


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
ggtgttggtg gcaggtaaga gt                                                22


<210>  20
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
tgaggaaatg gtaaacccag aacaga                                            26


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
tggtgtgtca tcagggtatg tttc                                              24


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
tgagcctggt gggattactc t                                                 21


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
tagcagtgga agttgcctag gtcc                                              24


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
ccgtcaaggc cagtgctt                                                     18


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
gcaagcctgt tggagactca g                                                 21


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
caccgtagct gcgacactgt gg                                                22


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  27
agacacgaac tcctctttgg a                                                 21


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  28
tgggctgagc cacatctc                                                     18


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  29
cagactccac acagcggcgc t                                                 21


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  30
tcagttccat ccaggcagat tc                                                22


