                         SEQUENCE LISTING

<110>  MeiraGTx UK II Limited
       MeiraGTx, LLC
       Volles, Michael J.
       Danos, Olivier F.
       Guo, Xuecui
 
<120>  REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED BLOCKING OF 
       POLYADENYLATION

<130>  162027.46576

<140>  PCT/US17/16279
<141>  2017-02-02

<150>  U.S. 62/290,200
<151>  2016-02-02

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus U1 binding site

<400>  1
caggtaagta                                                              10


<210>  2
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant U1 binding site

<400>  2
catggaacta                                                              10


<210>  3
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-87 wt in pRL-SV40

<400>  3
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtaagtac aactagaatg      120

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt      180

ataagctgca ataaacaagt taacaacaac                                       210


<210>  4
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-87 mut in pRL-SV40

<400>  4
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc atggaactac aactagaatg      120

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt      180

ataagctgca ataaacaagt taacaacaac                                       210


<210>  5
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-140 wt in pRL-SV40

<400>  5
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca ggtaagtagc       60

ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa      120

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca      180

ttataagctg caataaacaa gttaacaaca ac                                    212


<210>  6
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1-140 mut in pRL-SV40

<400>  6
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca tggaactagc       60

ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa      120

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca      180

ttataagctg caataaacaa gttaacaaca ac                                    212


<210>  7
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xU1-140 wt in pRL-SV40

<400>  7
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca ggtaagtaac       60

caaacaggta agtagcggcc gcttcgagca gacatgataa gatacattga tgagtttgga      120

caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt      180

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaac                   228


<210>  8
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xU1-140 mut in pRL-SV40

<400>  8
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca tggaactaac       60

caaacatgga actagcggcc gcttcgagca gacatgataa gatacattga tgagtttgga      120

caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt      180

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaac                   228


<210>  9
<211>  244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3xU1-140 wt in pRL-SV40

<400>  9
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca ggtaagtaac       60

caaacaggta agtaaccaaa caggtaagta gcggccgctt cgagcagaca tgataagata      120

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga      180

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa      240

caac                                                                   244


<210>  10
<211>  244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3xU1_140 mut in pRL-SV40

<400>  10
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagaca tggaactaac       60

caaacatgga actaaccaaa catggaacta gcggccgctt cgagcagaca tgataagata      120

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga      180

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa      240

caac                                                                   244


<210>  11
<211>  209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-9 in pRL-SV40

<400>  11
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtaagtca actagaatgc      120

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta      180

taagctgcaa taaacaagtt aacaacaac                                        209


<210>  12
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-8 in pRL-SV40

<400>  12
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtaagcaa ctagaatgca      120

gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat      180

aagctgcaat aaacaagtta acaacaac                                         208


<210>  13
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-7 in pRL-SV40

<400>  13
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtaacaac tagaatgcag      120

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata      180

agctgcaata aacaagttaa caacaac                                          207


<210>  14
<211>  206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-6 in pRL-SV40

<400>  14
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtacaact agaatgcagt      120

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa      180

gctgcaataa acaagttaac aacaac                                           206


<210>  15
<211>  205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-5 in pRL-SV40

<400>  15
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aggtcaacta gaatgcagtg      120

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag      180

ctgcaataaa caagttaaca acaac                                            205


<210>  16
<211>  238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1 87-9 SL in pRL-SV40

<400>  16
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttaccga      120

aaggtaactt acctgggcaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg      180

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaac        238


<210>  17
<211>  238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1 87-9 SL broken in pRL-SV40

<400>  17
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttaccga      120

aaaaaacaaa caaaaaacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg      180

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaac        238


<210>  18
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_1 in pRL-SV40

<400>  18
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttaccgg      120

cgataccagc cgaaaggccc ttggcagcgt cggtaactta cctgggcaac tagaatgcag      180

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata      240

agctgcaata aacaagttaa caacaac                                          267


<210>  19
<211>  265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_2 in pRL-SV40

<400>  19
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttacggc      120

gataccagcc gaaaggccct tggcagcgtc gtaacttacc tgggcaacta gaatgcagtg      180

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag      240

ctgcaataaa caagttaaca acaac                                            265


<210>  20
<211>  263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_3 in pRL-SV40

<400>  20
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttacgcg      120

ataccagccg aaaggccctt ggcagcgtgt aacttacctg ggcaactaga atgcagtgaa      180

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct      240

gcaataaaca agttaacaac aac                                              263


<210>  21
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_4 in pRL-SV40

<400>  21
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttagcga      120

taccagccga aaggcccttg gcagcgttaa cttacctggg caactagaat gcagtgaaaa      180

aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc      240

aataaacaag ttaacaacaa c                                                261


<210>  22
<211>  259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_5 in pRL-SV40

<400>  22
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttacgat      120

accagccgaa aggcccttgg cagcgtaact tacctgggca actagaatgc agtgaaaaaa      180

atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa      240

taaacaagtt aacaacaac                                                   259


<210>  23
<211>  257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_6 in pRL-SV40

<400>  23
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttcgata      120

ccagccgaaa ggcccttggc agcgaactta cctgggcaac tagaatgcag tgaaaaaaat      180

gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata      240

aacaagttaa caacaac                                                     257


<210>  24
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_7 in pRL-SV40

<400>  24
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagttgatac      120

cagccgaaag gcccttggca gcaacttacc tgggcaacta gaatgcagtg aaaaaaatgc      180

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa      240

caagttaaca acaac                                                       255


<210>  25
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8 in pRL-SV40

<400>  25
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttacctg ggcaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  26
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9 in pRL-SV40

<400>  26
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttacctggg caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  27
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_1 in pRL-SV40

<400>  27
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttacctg gacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  28
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_2 in pRL-SV40

<400>  28
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttacctg aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  29
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_3 in pRL-SV40

<400>  29
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttaccta aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  30
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_4 in pRL-SV40

<400>  30
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttaccaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  31
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_5 in pRL-SV40

<400>  31
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttacaaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  32
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_6 in pRL-SV40

<400>  32
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttaaaaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  33
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_7 in pRL-SV40

<400>  33
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttcaaaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  34
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_8 in pRL-SV40

<400>  34
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cactacaaaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  35
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_8_9 in pRL-SV40

<400>  35
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacaacaaaa aacaactaga atgcagtgaa aaaaatgctt      180

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca      240

agttaacaac aac                                                         253


<210>  36
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_1 in pRL-SV40

<400>  36
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttacctgga caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  37
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_2 in pRL-SV40

<400>  37
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttacctgaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  38
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_3 in pRL-SV40

<400>  38
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttacctaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  39
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_4 in pRL-SV40

<400>  39
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttaccaaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  40
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_5 in pRL-SV40

<400>  40
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttacaaaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  41
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_6 in pRL-SV40

<400>  41
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttaaaaaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  42
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_7 in pRL-SV40

<400>  42
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga cttcaaaaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  43
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_theo_9_8 in pRL-SV40

<400>  43
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtatacca      120

gccgaaaggc ccttggcaga ctacaaaaaa caactagaat gcagtgaaaa aaatgcttta      180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      240

ttaacaacaa c                                                           251


<210>  44
<211>  539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4xU1_theo_8_1 in pRL-SV40

<400>  44
tcaaatcgtt cgttgagcga gttctcaaaa atgaacaata attctagagc ggccgcttcg       60

agcagacatg ataagataca ttgatgagtt tggacaaacc aaacccaggt aagtgatacc      120

agccgaaagg cccttggcag cacttacctg gacaactaga atgcagtgaa aaaagagttt      180

ggacaaacca aacccaggta agtgatacca gccgaaaggc ccttggcagc acttacctgg      240

acaactagaa tgcagtgaaa aaaatgcgag tttggacaaa ccaaacccag gtaagtgata      300

ccagccgaaa ggcccttggc agcacttacc tggacaacta gaatgcagtg aaaaaaatgc      360

tttatttgtg agagtttgga caaaccaaac ccaggtaagt gataccagcc gaaaggccct      420

tggcagcact tacctggaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt      480

gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaac       539


<210>  45
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_1 wt in pFLuc

<400>  45
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat taaggtaatg       60

tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactacat      120

tactgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca      180

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  46
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_1 mut in pFLuc

<400>  46
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat taatggaatc       60

tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactagat      120

tcctgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca      180

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  47
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_2 wt in pFLuc

<400>  47
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat ttgtagaggt       60

tttacttgct ttaaaaaacc tcccacacct aaggtaatgt ataatcgcgt ggatatggca      120

cgcaagtttc taccgggcac cgtaaatgtc cgactacatt acccccctga acctgaaaca      180

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  48
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_2 mut in pFLuc

<400>  48
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat ttgtagaggt       60

tttacttgct ttaaaaaacc tcccacacct aatggaatct ataatcgcgt ggatatggca      120

cgcaagtttc taccgggcac cgtaaatgtc cgactagatt ccccccctga acctgaaaca      180

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  49
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_3 wt in pFLuc

<400>  49
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat ttgtagaggt       60

tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc      120

aattgtaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      180

aatgtccgac tacattactg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  50
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1_Gua_3 mut in pFLuc

<400>  50
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagc cataccacat ttgtagaggt       60

tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc      120

aattgtaatg gaatctataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      180

aatgtccgac tagattcctg ttgttaactt gtttattgca gcttataatg gttacaaata      240

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaa                                         328


<210>  51
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtU1_Gua_HBGPA

<400>  51
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagg atccaagctt atcgataccg       60

tcgacctcga ggtaatgtat aatcgcgtgg atatggcacg caagtttcta ccgggcaccg      120

taaatgtccg actacattac ggcccagatc taattcaccc caccagtgca ggctgcctat      180

cagaaagtgg tggctggtgt ggctaatgcc ctggcccaca agtatcacta agctcgcttt      240

cttgctgtcc aatttctatt aaaggttcct ttgttcccta agtccaacta ctaaactggg      300

ggatattatg aagggccttg agcatctgga ttctgcctaa taaaaaacat ttattttcat      360

tgcaatgatg tattt                                                       375


<210>  52
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutU1_Gua_HBGPA

<400>  52
tcataaaggc caagaagggc ggaaagatcg ccgtgtaagg atccaagctt atcgataccg       60

tcgacctcga tggaatctat aatcgcgtgg atatggcacg caagtttcta ccgggcaccg      120

taaatgtccg actacattac ggcccagatc taattcaccc caccagtgca ggctgcctat      180

cagaaagtgg tggctggtgt ggctaatgcc ctggcccaca agtatcacta agctcgcttt      240

cttgctgtcc aatttctatt aaaggttcct ttgttcccta agtccaacta ctaaactggg      300

ggatattatg aagggccttg agcatctgga ttctgcctaa taaaaaacat ttattttcat      360

tgcaatgatg tattt                                                       375


