                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> MITOCHONDRIAL GENOME EDITING AND REGULATION

<130> 010498.00903/WO

<140>
<141>

<150> 62/291,040
<151> 2016-02-04

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
acactctttc cctacacgac gctcttccga tcgcgctctc aacctaattt atga             54


<210> 2
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
gtgactggag ttcagacgtg tgctcttccg atctttgaac ctctgggaac aagg             54


<210> 3
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
acactctttc cctacacgac gctcttccga tcacttcaca aagcgccttc c                51


<210> 4
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
gtgactggag ttcagacgtg tgctcttccg atctgaagag gaattgaacc tctgactg         58


<210> 5
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
ccctacacga cgctcttccg atccaataac ttgaccaacg gaaca                       45


<210> 6
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
gttcagacgt gtgctcttcc gatctacctt taatagcggc tgcac                       45


<210> 7
<211> 1386
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg       60

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      120

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      180

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      240

gacgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct      300

gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta      360

attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg      420

ggctccggga gggccctttg tgcgggggga gcggctcggg gctgtccgcg gggggacggc      480

tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct      540

agagcctctg ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg      600

ctggttattg tgctgtctca tcattttggc aaagaattgg atcgggatcc ccgggtaccg      660

gtcgccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc      720

gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat      780

gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc      840

tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac      900

cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc      960

accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc     1020

gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc     1080

ctggggcaca agctggagta caactacaac agccacaacg tctatatcat ggccgacaag     1140

cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga cggcagcgtg     1200

cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc     1260

gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga gaagcgcgat     1320

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg     1380

tacaag                                                                1386


<210> 8
<211> 3422
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
ccgctgctaa ccccataccc cgaaccaacc aaaccccaaa gacacccccc gccaccatga       60

gcgacctggt gctgggcctg gacatcggca tcggcagcgt gggcgtgggc atcctgaaca      120

aggtgaccgg cgagatcatc cacaagaaca gtcgcatctt ccctgctgct caggctgaga      180

acaacctggt gcgccgcacc aaccgccagg gtcgccggct tgctcgccgc aagaagcacc      240

ggcgcgtgcg cctgaaccgc ctgttcgagg agagcggcct gatcaccgac ttcaccaaga      300

tcagcatcaa cctgaacccc taccagctgc gcgtgaaggg cctgaccgac gagctgagca      360

acgaggagct gttcatcgcc ctgaagaaca tggtgaagca ccgcggcatc agctacctgg      420

acgacgccag cgacgacggc aacagcagcg tgggcgacta cgcccagatc gtgaaggaga      480

acagcaagca gctggagacc aagacccccg gccagatcca gctggagcgc taccagacct      540

acggccagct gcgcggcgac ttcaccgtgg agaaggacgg caagaagcac cgcctgatca      600

acgtgttccc caccagcgcc taccgcagcg aggccctgcg catcctgcag acccagcagg      660

agttcaaccc ccagatcacc gacgagttca tcaaccgcta cctggagatc ctgaccggca      720

agcgcaagta ctaccacggc cccggcaacg agaagagccg caccgactac ggccgctacc      780

gcaccagcgg cgagaccctg gacaacatct tcggcatcct gatcggcaag tgcaccttct      840

accccgacga gttccgcgcc gccaaggcca gctacaccgc ccaggagttc aacctgctga      900

acgacctgaa caacctgacc gtgcccaccg agaccaagaa gctgagcaag gagcagaaga      960

accagatcat caactacgtg aagaacgaga aggccatggg ccccgccaag ctgttcaagt     1020

acatcgccaa gctgctgagc tgcgacgtgg ccgacatcaa gggctaccgc atcgacaaga     1080

gcggcaaggc cgagatccac accttcgagg cctaccgcaa gatgaagacc ctggagaccc     1140

tggacatcga gcagatggac cgcgagaccc tggacaagct ggcctacgtg ctgaccctga     1200

acaccgagcg cgagggcatc caggaggccc tggagcacga gttcgccgac ggcagcttca     1260

gccagaagca ggtggacgag ctggtgcagt tccgcaaggc caacagcagc atcttcggca     1320

agggctggca caacttcagc gtgaagctga tgatggagct gatccccgag ctgtacgaga     1380

ccagcgagga gcagatgacc atcctgaccc gcctgggcaa gcagaagacc accagcagca     1440

gcaacaagac caagtacatc gacgagaagc tgctgaccga ggagatctac aaccccgtgg     1500

tggccaagag cgtgcgccag gccatcaaga tcgtgaacgc cgccatcaag gagtacggcg     1560

acttcgacaa catcgtgatc gagatggccc gcgagaccaa cgaggacgac gagaagaagg     1620

ccatccagaa gatccagaag gccaacaagg acgagaagga cgccgccatg ctgaaggccg     1680

ccaaccagta caacggcaag gccgagctgc cccacagcgt gttccacggc cacaagcagc     1740

tggccaccaa gatccgcctg tggcaccagc agggcgagcg ctgcctgtac accggcaaga     1800

ccatcagcat ccacgacctg atcaacaaca gcaaccagtt cgaggtggac cacatcctgc     1860

ccctgagcat caccttcgac gacagcctgg ccaacaaggt gctggtgtac gccaccgcca     1920

accaggagaa gggccagcgc accccctacc aggccctgga cagcatggac gacgcctgga     1980

gcttccgcga gctgaaggcc ttcgtgcgcg agagcaagac cctgagcaac aagaagaagg     2040

agtacctgct gaccgaggag gacatcagca agttcgacgt gcgcaagaag ttcatcgagc     2100

gcaacctggt ggacacccgc tacgccagcc gcgtggtgct gaacgccctg caggagcact     2160

tccgcgccca caagatcgac accaaggtga gcgtggtgcg cggccagttc accagccagc     2220

tgcgccgcca ctggggcatc gagaagaccc gcgacaccta ccaccaccac gccgtggacg     2280

ccctgatcat tgcggcttct agccagctga acctgtggaa gaagcagaag aacaccctgg     2340

tgagctacag cgaggaccag ctgctggaca tcgagaccgg cgagctgatc agcgacgacg     2400

agtacaagga gagcgtgttc aaggccccct accagcactt cgtggacacc ctgaagagca     2460

aggagttcga ggacagcatc ctgttcagct accaggtgga cagcaagttc aaccgcaaga     2520

tcagcgacgc caccatctac gccacccgcc aggccaaggt gggcaaggac aaggccgacg     2580

agacctacgt gctgggcaag atcaaggaca tctacaccca ggacggctac gacgccttca     2640

tgaagatcta caagaaggac aagagcaagt tcctgatgta ccgccacgac ccccagacct     2700

tcgagaaggt gatcgagccc atcctggaga actaccccaa caagcagatc aacgataaag     2760

gcaaggaggt gccctgcaac cccttcctga agtacaagga ggagcacggc tacatccgca     2820

agtacagcaa gaagggcaac ggccccgaga tcaagagcct gaagtactac gacagcaagc     2880

tgggcaacca catcgacatc acccccaagg acagcaacaa caaggtggtg ctgcagagcg     2940

tgagcccctg gcgcgccgac gtgtacttca acaagaccac cggcaagtac gagatcctgg     3000

gcctgaagta cgccgacctg cagtttgata agggcaccgg cacctacaag atcagccagg     3060

agaagtacaa cgacatcaag aagaaggagg gcgtggacag cgacagcgag ttcaagttca     3120

ccctgtacaa gaacgacctt ctgctggtga aggacaccga gaccaaggag caacagctgt     3180

tccgcttcct gagccgcacc atgcccaagc agaagcacta cgtggagctg aagccctacg     3240

acaagcagaa gttcgagggc ggcgaggccc tgatcaaggt gctgggcaac gtggccaaca     3300

gcggccagtg caagaagggc ctgggcaaga gcaacatcag catctacaag gtgcgcaccg     3360

acgtgctggg caaccagcac atcatcaaga acgagggcga caagcccaag ctggacttct     3420

aa                                                                    3422


<210> 9
<211> 6318
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1593)..(1593)
<223> a, c, t, g, unknown or other

<400> 9
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctgcg       60

cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg      120

cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactcca tcactagggg      180

ttccttgtag ttaatgatta acccgccatg ctacttatct acgtagccat gctctaggaa      240

gatcgtacca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      300

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      360

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      420

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      480

catcgctatt accatggtta gctggttgtc caagatagaa tcttagttca actttaaatt      540

tgcccacaga accctctaaa tccccttgta aatttaactg ttagtccaaa gaggaacagc      600

tctttggaca ctaggaaaaa accttgtaga gagagtaaaa aatttaacac ccatagtagg      660

cctaaaagca gccaccaatt aagaaagcgt tcaagctcaa cacccactac ctaaaaaatc      720

ccaaacatat aactgaactc ctcacaccca attggaccaa tctatcaccc tatagaagaa      780

ctaatgttag tataagtaac atgaaaacat tctcctccgc ataagcctgc gtcagattaa      840

aacactgaac tgacaattaa cagcccaata tctacaatca accaacaagt cattattacc      900

ctcactgtca acccaacaca ggcatgctca taaggaaagg ttaaaaaaag taaaaggaac      960

tcggcaaatc ttaccccgcc tgtttaccaa aaacatcacc tctagcatca ccagtattag     1020

aggcaccgcc tgcccagtga cacatgttta acggccgcgg taccctaacc gtgcaaaggt     1080

agcataatca cttgttcctt aaatagggac ctgtatgaat ggctccacga gggttcagct     1140

gtctcttact tttaaccagt gaaattgacc tgcccgtgaa gaggcgggca taacacagca     1200

agacgagaag accctatgga gctttaattt attaatgcaa acagtaccta acaaacccac     1260

aggtcctaaa ctaccaaacc tgcattaaaa atttcggttg gggcgacctc ggagcagaac     1320

ccaacctccg agcagtacat gctaagactt caccagtcaa agcgaactac tatactcaat     1380

tgatccaata acttgaccaa cggaacaagt taccctaggg ataacagcgc aatcctattc     1440

tagagtccat atcaacaata gggtttacga cctcgacgtt ggatcaggac atcccgatgg     1500

tgcagccgct attaaaggtt cgtttgttca acgattaaag tcctacgtga tctgagttca     1560

gaccggagta atccaggtcg gtttctatct acnttcaaat tcctccctgt acgaaaggac     1620

aagagaaata aggcctactt cacaaagcgc cttcccccgt aaatgatatc atctcaactt     1680

agtattatac ccacacccac ccaagaacag ggtttgttaa gatggcaggg cccggtaatc     1740

gcataaaact taaaacttta cagtcagagg ttcaattcct cttcttaaca acatacccat     1800

ggccaacctc ctactcctca ttgtacccat tctaatcgca atggcattcc taatgcttac     1860

cgaacgaaaa attctaggct atatacaact acgcaaaggc cccaacgttg taggccccta     1920

cgggctacta caacccttcg ctgacgccat aaaactcttc accaaagagc ccctaaaacc     1980

cgccacatct accatcaccc tctacatcac cgccccgacc ttagctctca ccatcgctct     2040

tctactatga acccccctcc ccatacccaa ccccctggtc aacctcaacc taggcctcct     2100

atttattcta gccacctcta gcctagccgt ttactcaatc ctctgatcag ggtgagcatc     2160

aaactcaaac tacgccctga tcggcgcact gcgagcagta gcccaaacaa tctcatatga     2220

agtcacccta gccatcattc tactatcaac attactaata agtggctcct ttaacctctc     2280

cacccttatc acaacacaag aacacctctg attactcctg ccatcatgac ccttggccat     2340

aatatgattt atctccacac tagcagagac caaccgaacc cccttcgacc ttgccgaagg     2400

ggagtccgaa ctagtctcag gcttcaacat cgaatacgcc gcaggcccct tcgccctatt     2460

cttcatagcc gaatacacaa acattattat aataaacacc ctcaccacta caatcttcct     2520

aggaacaaca attagcgctt ggtttaatga cggcttgttt cttttctgta caaaaaagca     2580

ggctttaaag gaaccaattc agtcgactgg atccggtacc aaggtcgggc aggaagaggg     2640

cctatttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat     2700

tagaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta     2760

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct     2820

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggacgaaa     2880

caccggataa cagcgcaatc ctattgtttt tgtactctca gaaatgcaga agctacaaag     2940

ataaggcttc atgccgaaat caacaccctg tcattttatg gcagggtgtt tttttgacct     3000

tgccgaaggg gagtccgaac tagtctcaga tgtacaaaaa agcaggcttt aaaggaacca     3060

attcagtcga ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt     3120

ccttcatatt tgcatatacg atacaaggct gttagagaga taattagaat taatttgact     3180

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag     3240

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag     3300

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgt ttacgacctc     3360

gatgttggag tttttgtact ctcagaaatg cagaagctac aaagataagg cttcatgccg     3420

aaatcaacac cctgtcattt tatggcaggg tgttttttta agttaacaac aacaattgca     3480

ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc     3540

tctacaaatg tggtaaaatc gataaggatc ttcctagagc atggctacgt agataagtag     3600

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     3660

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     3720

gcccgggcgg cctcagtgag cgagcgagcg cgcagcctta attaacctaa ttcactggcc     3780

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     3840

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     3900

caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg     3960

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     4020

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     4080

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     4140

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     4200

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     4260

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     4320

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt     4380

acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     4440

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     4500

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     4560

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     4620

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     4680

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     4740

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     4800

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     4860

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     4920

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     4980

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     5040

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     5100

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     5160

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     5220

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     5280

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     5340

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     5400

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     5460

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     5520

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     5580

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     5640

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc     5700

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     5760

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     5820

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     5880

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     5940

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     6000

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     6060

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     6120

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     6180

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     6240

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     6300

tgagcgagga agcggaag                                                   6318


<210> 10
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tatcaacaat agggtttacg acctcgatgt tggatcagga c                           41


<210> 11
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
tggcagagcc cg                                                           12


