                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas System
 
<120>  MUTATIONS THAT DRIVE VH4 ANTIBODY AUTOREACTIVITY

<130>  UTFD.P3011WO

<140>  PCT/US2017/015755
<141>  2017-01-31

<150>  US 62/289,736
<151>  2016-02-01

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala 
            100 


<210>  2
<211>  249
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ttggatccgc      120

cagcccccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagct gagctctgtg actgccgcag acacggccgt gtattactgt      240

gccagagca                                                              249


<210>  3
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Asp His Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser His Gly Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Ile Asp Thr Ser Thr Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Val Thr Ser Val Arg Ala Ala Asp Met Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Pro Ala Pro Ile Thr Thr Phe Gly Met Val Thr Pro 
            100                 105                 110         


Val Pro Tyr Phe His Ser 
        115             


<210>  4
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (231)..(231)
<223>  n is a, c, g, or t

<400>  4
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcga ctccgtcagc agtaatgatc actactggag ttggatccgc      120

cagcccccag ggcagggcct ggagtggatt gggtacatct ctcacggtgg gaccacctac      180

tacaacccgt ccctcaagag tcgagttacc atgtcgatcg acacgtccac naaccagttc      240

tccctgaggg tgacctccgt gcgagccgca gacatggccg tctacttctg tgccagggcc      300

ccggccccta taacgacttt tggaatggtg acaccagtcc cctactttca ctcc            354


<210>  5
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Asp His Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser His Gly Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Ile Asp Thr Ser Thr Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Val Thr Ser Val Arg Ala Ala Asp Met Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Pro Ala Pro Ile Thr Thr Phe Gly Met Val Thr Pro 
            100                 105                 110         


Val Pro Tyr Phe His Ser 
        115             


<210>  6
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcga ctccgtcagc agtaatgatc actactggag ttggatccgc      120

cagcccccag ggcagggcct ggagtggatt gggtacatct ctcacggtgg gaccacctac      180

tacaacccgt ccctcaagag tcgagttacc atgtcgatcg acacgtccac gaaccagttc      240

tccctgaggg tgacctccgt gcgagccgca gacatggccg tctacttctg tgccagggcc      300

ccggccccta taacgacttt tggaatggtg acaccagtcc cctactttca ctcc            354


<210>  7
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg 
            


<210>  8
<211>  297
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgtactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgaga         297


<210>  9
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly His Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Val Tyr Tyr Ser Gly Ser Thr Tyr Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Asp Ser Arg Leu Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Asn Val Thr Val Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Asn Trp Glu Gly Glu Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly 
    


<210>  10
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgtactg tctctggtgg ctccatcagc agtggtggtc actactggag ctggatccgc      120

cagtccccag ggaagggcct ggagtggatt gggaacgtct attatagtgg aagcacctac      180

tacaccccgt ccctcgacag ccgacttacc atatcattag acacgtctaa gaaccagttc      240

tccctgaggc tgagtaatgt gactgtcgcg gacacggccg tctattactg tgcgagaggt      300

agaaattggg agggcgaatt cgacccctgg ggccaagga                             339


<210>  11
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly 
        


<210>  12
<211>  294
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggg            294


<210>  13
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Glu Phe 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Arg Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Arg Ala Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Pro Val Ala Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Glu Ile Val Val Thr Val Arg Gly Arg Arg Ala Phe Asp Ile 
            100                 105                 110         


<210>  14
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcaat gaattctact ggagctggat ccgtcagccc      120

gcacggaagg gcctggagtg gattggagaa atcagtcata gcggaagagc caactacaac      180

ccgtccctca agagtcgcgt caccctgtct gtagacaggt ccaagaacca gttctccctg      240

aacctgagcc ctgtggccgc cgcggacaca gctgtctatt actgtgcgcg acgggagata      300

gtcgtaactg ttcgggggcg tcgtgctttt gatatc                                336


<210>  15
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Asn His Ser Gly Asp Ala Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Val Thr Val Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Gln Gly Ser Arg Leu Thr Thr Phe Ala Phe Asp Val 
            100                 105                 


<210>  16
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctttggtgg gtccctcagt ggttactact ggagttggat ccgccagccc      120

ccagggaagg ggccggagtg gattgcggaa atcaatcata gtggagatgc caactacaac      180

ccgtccctca agagtcgagt cactatctca gtagacacgt ccaagaacca gttttccctg      240

aagatgagtt ctgtgaccgt cgcagacacg gctttatatt actgtgcgac tcaaggctct      300

aggttgacta cattcgcttt tgatgtg                                          327


<210>  17
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp 
            100 


<210>  18
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagagat      300


<210>  19
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Ser 
            20                  25                  30          


Arg Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Gln Ser Gly Ser Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Met Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg His Ser Asn Pro Gly Thr Ala Asn Lys Leu Arg Leu Gly 
            100                 105                 110         


Glu Phe Ser Pro 
        115     


<210>  20
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acgtgcactg tctctggtgc ctccatcagc agtagtcgtt cctactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatgt atcaaagtgg gagcacttac      180

tacagtccgt ccctcaagag tcgagtcacc atatccatgg acacgtccaa gaaccagttc      240

tccctaaacc tgacgtctgt gaccgccgcg gacacggctg tgtatttctg tgcgagacat      300

tcgaaccccg gaacggcgaa caaattgcgt ttgggggagt tttcgccc                   348


<210>  21
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Arg 
            20                  25                  30          


Asn Asn Tyr Trp Gly Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Leu Tyr Tyr Thr Gly Ser Asp Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg Val Asn Val Asp Asp Phe Trp Ser Gly Leu Gly Gly Ala 
            100                 105                 110         


Trp Phe Asp Pro 
        115     


<210>  22
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcacc agtaggaata actactgggg ctggatccgc      120

cagtccccag ggaaggggct ggagtggatt gggagtctct attatactgg gagcgactac      180

tacaacccgt ccctcaagag tcgagtcacc atatcggtag acacatcgaa gaaccaattc      240

tccctgaggc tgagttctgt gaccgccgcg gacacggccg tgtattattg tgtcagagtt      300

aacgtagacg acttttggag tggtttaggg ggggcctggt tcgacccc                   348


<210>  23
<211>  97
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  24
<211>  291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

gccgggaagg gactggagtg gattgggcgt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag a               291


<210>  25
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ala Val Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Ala Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Ile Asn Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Val Ser Met Ser Val Asp Thr Ser Lys Gly Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Ala Leu Leu Gly Asp Tyr Tyr Tyr Gly Leu Asp Val 
            100                 105                 110     


<210>  26
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acgtgcagtg tctctggtgg cgccgtcagt aattactact ggagttggat ccggcagtcc      120

gccgggaagg gactggagtg gcttgggcgg atctatatca atggaactac ttactacaac      180

ccctccctca ggagccgggt ctccatgtca gttgacacgt ccaagggcca gttctccctg      240

aggttgacct ctgtgaccgc cgcggacacg gccatatatt attgtgcgag atggggtgcc      300

ctattgggcg actactatta cggtttggac gtc                                   333


<210>  27
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Asn Asn 
            20                  25                  30          


Lys Trp Trp Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Leu Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Thr Thr Met Val Arg Gly Leu Ser Leu Tyr Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val 
        115 


<210>  28
<211>  345
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc aataataagt ggtggaattg ggtccgccag      120

tccccaggga aggggctgga gtggattggg gaaatctatc atagtggggg caccaactac      180

aacccgtccc tcaagagtcg agtcaccata tcggtagaca agtccaagaa cctgttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc gagtgcgact      300

actatggttc ggggactgag tctttactac tacggtctgg acgtc                      345


<210>  29
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Asn Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu 
        


<210>  30
<211>  294
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca atgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaa            294


<210>  31
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Asn Gly Asn Ile Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Met Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Ile Gly Tyr Ser Ala Val Ala Ala Gly Thr Val Asp Tyr 
            100                 105                 


<210>  32
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaac aactattact ggagttggat ccggcagccc      120

ccagggaagg gactggagtg gattggttat atctattaca atgggaatat taattacaac      180

ccttccctca agagtcgagt caccatatca agagacatgt ccaagaacca gttctccctg      240

aacctgcggt ctgtgaccgc tgcggacacg gccgtgtatt actgtggaat tggatatagt      300

gcggtggcag ctggtacagt tgactac                                          327


<210>  33
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro 
                85                  90                  95  


<210>  34
<211>  285
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaggctc ctaaactcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accct                      285


<210>  35
<211>  97
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Ile Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Thr Phe Pro Tyr 
                85                  90                  95      


Thr 
    


<210>  36
<211>  291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtggtttag cctggtatca gcaggaacca      120

gggaaagctc ctaaactcct gatctatgat gcctccactt tggaaagtgg ggtcccatca      180

agattcagcg gcagtggatc tgcaatagat ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatactt tcccgtatac t               291


<210>  37
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro 
                85                  90                  95  


<210>  38
<211>  285
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccct                      285


<210>  39
<211>  97
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Gln Met Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Tyr 
                85                  90                  95      


Thr 
    


<210>  40
<211>  291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaac aactatttaa attggtttca gcagcaacca      120

gggaaagccc ctaagctgct gatctacgat gcatccaaat tgcaaatggg ggtcccatca      180

aggttcagtg gaagtgcatc tgggacagat tttactttta ccatcagcag cctgcagcct      240

gaagatattg gcacatatta ctgtcaacag tattataatc tcccgtacac t               291


<210>  41
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  42
<211>  285
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctctgtaa attggtttca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccct                      285


<210>  43
<211>  97
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ser 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Pro Arg 
                85                  90                  95      


Thr 
    


<210>  44
<211>  291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agctctgtaa attggtttca gcagaaacca      120

gggaaagccc ctgaactcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

agattcagtg gcagtggatc tgggacagat ttcactctca ccgtcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcag agttacagtc cccctcgaac t               291


<210>  45
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro 
            100 


<210>  46
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca atctccacaa ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcct      300


<210>  47
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Glu Tyr Ile Tyr Leu Asp Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Glu Ala Pro Trp Thr 
            100         


<210>  48
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctactca gagcctccta cacagtaatg aatacattta tttggattgg      120

tacgtgcaga agccagggca gtctccacaa ctcctgatct ttttggcttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt gcatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct agaagctccg      300

tggacg                                                                 306


<210>  49
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Ser Ser Ser Ile Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr 
            100         


<210>  50
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctc catagtaatg gatacaacta tttgagttgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatct tttcgagttc tattcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgacaatc      240

aacagagtgg aggctgagga tgttggagtt tattactgca tgcaggctct acaaactccg      300

ctcact                                                                 306


<210>  51
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Ser Ser Ser Ile Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr 
            100         


<210>  52
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctc catagtaatg gatacaacta tttgagttgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatct tttcgagttc tattcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgacaatc      240

aacagagtgg aggctgagga tgttggagtt tattactgca tgcaggctct acaaactccg      300

ctcact                                                                 306


<210>  53
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro 
            100 


<210>  54
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct atgaagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acagcttcct      300


<210>  55
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr His Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Ser Leu Ile Tyr Glu Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ala Gln Leu Pro Tyr Thr 
            100         


<210>  56
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  56
gatattgtga tgacccagac tccactctct ttgtccgtca cccctggaca gccggcctcc       60

atctcctgca aatctagtca gagcctcctg gatagtgatg gaaagaccca tttgtactgg      120

tacctgcaga agccaggcca gtctccacag tccctgatct atgaagtttc taaacggttc      180

tctggagtgc cagataggtt cactggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttgggctt tattactgca tgcaaagtgc acagcttccg      300

tacact                                                                 306


<210>  57
<211>  96
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  58
<211>  288
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  58
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacct                   288


<210>  59
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ile Gly Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr His Thr Ser Asn Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr 
        


<210>  60
<211>  294
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  60
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttatc ggcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat catacatcca acagggcctc tggcatccca      180

gacaggttca gtggcggtgg gtttgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcaa cagtatgata gctcaccgat cacc            294


<210>  61
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr His Thr Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ala Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Arg Ser Ser 
                85                  90                  95      


Leu Phe Thr 
            


<210>  62
<211>  297
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  62
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcgactcct tagcctggta ccagcagaaa      120

cctggccaga ctcccaggct cctcatttat catacatcca ccagggccgc tggcatccca      180

gacaggttca gtggcactgg gtctgggaca gacttcactc tcaccatcgc cagactggag      240

cctgaagatt ttgcagtcta ttactgtcag cactatggtc ggtcatccct attcacc         297


<210>  63
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ile Gly Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr His Thr Ser Asn Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr 
        


<210>  64
<211>  294
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  64
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttatc ggcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat catacatcca acagggcctc tggcatccca      180

gacaggttca gtggcggtgg gtttgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcaa cagtatgata gctcaccgat cacc            294


