﻿                         SEQUENCE LISTING

<110>  MediaPharma S.r.l.
 
<120>  Antibodies against Endosilian

<130>  60112P WO

<150>  16154507.4
<151>  2016-02-05

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  1


Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  2
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1

<400>  2

Gly Tyr Gly Val Asn 
1               5   


<210>  3
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2

<400>  3

Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  4
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3

<400>  4

Gly Gly Tyr Gly Ala Met Asp Tyr 
1               5               


<210>  5
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1

<400>  5

His Ala Ser Gln Asn Ile Asn Val Trp Leu Thr 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2

<400>  6

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR_L3

<400>  7

Gln Gln Gly Gln Ser Tyr Pro Trp Thr 
1               5                   


<210>  8
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  vH


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  HFR-1

<220>
<221>  MISC_FEATURE
<222>  (26)..(35)
<223>  CDR-H1 (alternative)

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  CDR-H1

<220>
<221>  MISC_FEATURE
<222>  (36)..(49)
<223>  HFR-2

<220>
<221>  MISC_FEATURE
<222>  (50)..(65)
<223>  CDR-H2

<220>
<221>  MISC_FEATURE
<222>  (66)..(97)
<223>  HFR-3

<220>
<221>  MISC_FEATURE
<222>  (98)..(105)
<223>  CDR-H3

<220>
<221>  MISC_FEATURE
<222>  (106)..(116)
<223>  HFR-4

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Glu Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asn Ile Ser Lys Asp Lys Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  vL


<220>
<221>  MISC_FEATURE
<222>  (1)..(23)
<223>  LFR-1

<220>
<221>  MISC_FEATURE
<222>  (24)..(34)
<223>  CDR-L2

<220>
<221>  MISC_FEATURE
<222>  (35)..(49)
<223>  LFR-2

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR-L2

<220>
<221>  MISC_FEATURE
<222>  (57)..(88)
<223>  LFR-3

<220>
<221>  MISC_FEATURE
<222>  (89)..(97)
<223>  CDR-L3

<220>
<221>  MISC_FEATURE
<222>  (98)..(107)
<223>  LFR-4

<400>  9

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  135
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain


<220>
<221>  MISC_FEATURE
<222>  (20)..(135)
<223>  vH

<400>  10

Met Ala Val Leu Ala Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Ile Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Asn Ile Ser Lys Asp Lys Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser 
    130                 135 


<210>  11
<211>  135
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain


<220>
<221>  MISC_FEATURE
<222>  (20)..(135)
<223>  vH

<400>  11

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Asn Ile Ser Lys Asp Lys Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser 
    130                 135 


<210>  12
<211>  127
<212>  PRT
<213>  artificial

<220>
<223>  light chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(127)
<223>  vL

<400>  12

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Thr Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  13
<211>  126
<212>  PRT
<213>  artificial

<220>
<223>  light chain


<220>
<221>  MISC_FEATURE
<222>  (20)..(126)
<223>  vL

<400>  13

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Asn Val Trp Leu Thr Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  14
<211>  405
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain

<400>  14
atggctgtcc tggcattact cttctgcctg gtaacattcc caagctgtat cctttcccag       60

gtgcagctgc aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcaca      120

tgcaccgtct cagggttctc attaaccggc tatggtgtaa actgggttcg ccagcctcca      180

gaaaagggtc tggagtggct gggaatgata tgggttgatg gaagcacaga ctataattca      240

gctctcaaat ccagactgaa catcagcaag gacaagtcca agagccaagt tttcttaaaa      300

atgaacagtc tgcaaactga tgacacagcc aggtactact gtgccagagg gggctacggt      360

gctatggact actggggtca aggaacctca gtcaccgtct cctca                      405


<210>  15
<211>  1419
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain

<400>  15
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc       60

cagtgtcagg tccagctgca ggagtcaggt cccggcctgg tggcaccatc ccagagcctg      120

tctatcacct gcacggtctc cggcttcagc ctgacaggct acggagtgaa ctgggtcaga      180

cagccccctg agaaagggct ggaatggctg ggtatgatct gggtggacgg aagcaccgat      240

tataactctg ccctgaaaag taggctgaat atttccaagg ataagtcgaa gtcacaggtc      300

tttctgaaga tgaactccct gcagactgac gataccgccc ggtactattg tgctaggggg      360

gggtatggtg ctatggatta ttggggacag gggacaagcg tcacagtctc gagcgctagc      420

acaaagggcc ctagtgtgtt tcctctggct ccctcttcca aatccacttc tggtggcact      480

gctgctctgg gatgcctggt gaaggattac tttcctgaac ctgtgactgt ctcatggaac      540

tctggtgctc tgacttctgg tgtccacact ttccctgctg tgctgcagtc tagtggactg      600

tactctctgt catctgtggt cactgtgccc tcttcatctc tgggaaccca gacctacatt      660

tgtaatgtga accacaaacc atccaacact aaagtggaca aaaaagtgga acccaaatcc      720

tgtgacaaaa cccacacctg cccaccttgt cctgcccctg aactgctggg aggaccttct      780

gtgtttctgt tcccccccaa accaaaggat accctgatga tctctagaac ccctgaggtg      840

acatgtgtgg tggtggatgt gtctcatgag gaccctgagg tcaaattcaa ctggtacgtg      900

gatggagtgg aagtccacaa tgccaaaacc aagcctagag aggaacagta caattcaacc      960

tacagagtgg tcagtgtgct gactgtgctg catcaggatt ggctgaatgg caaggaatac     1020

aagtgtaaag tctcaaacaa ggccctgcct gctccaattg agaaaacaat ctcaaaggcc     1080

aagggacagc ctagggaacc ccaggtctac accctgccac cttcaagaga ggaaatgacc     1140

aaaaaccagg tgtccctgac atgcctggtc aaaggcttct acccttctga cattgctgtg     1200

gagtgggagt caaatggaca gcctgagaac aactacaaaa caaccccccc tgtgctggat     1260

tctgatggct ctttctttct gtactccaaa ctgactgtgg acaagtctag atggcagcag     1320

gggaatgtct tttcttgctc tgtcatgcat gaggctctgc ataaccacta cactcagaaa     1380

tccctgtctc tgtctcccgg gaaatgatag taaaagctt                            1419


<210>  16
<211>  381
<212>  DNA
<213>  artificial

<220>
<223>  light chain

<400>  16
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa cctggtacca gcagaaacca      180

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      240

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  17
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  light chain

<400>  17
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc       60

cagtgtgaca ttcagatgaa tcagtctcct tcctctctga gtgcctcact gggcgacacc      120

atcacaatta cttgccacgc ttcccagaac atcaatgtgt ggctgacatg gtatcagcag      180

aagcctggca acatccctaa gctgctgatc tacaaagcat caaatctgca tactggagtc      240

ccaagcaggt tctccggcag cggatctggg accggtttta ccctgacaat ctccagcctg      300

cagcccgagg atattgccac ctactattgt cagcaggggc agagctatcc ttggaccttc      360

gggggcggca ctaaactgga aatcaaacgt acggtcgcgg cgccttctgt gttcattttc      420

cccccatctg atgaacagct gaaatctggc actgcttctg tggtctgtct gctgaacaac      480

ttctacccta gagaggccaa agtccagtgg aaagtggaca atgctctgca gagtgggaat      540

tcccaggaat ctgtcactga gcaggactct aaggatagca catactccct gtcctctact      600

ctgacactga gcaaggctga ttacgagaaa cacaaagtgt acgcctgtga agtcacacat      660

caggggctgt ctagtcctgt gaccaaatcc ttcaataggg gagagtgctg atagtaaaag      720

ctt                                                                    723


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH1 (IGHV4-4*08)

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH2 (IGHV4-4*08 with germ line reversion)

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Asn Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH3 (IGHV4-61*05)

<400>  20

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH4 (IGHV4-61*05 with germ line reversion)

<400>  21

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Val Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Asn Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL1 (IGKV1-12*01)

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL2 (IGKV1-5*03)

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL3 (IGKV1D-33*01)

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VL4 (IGKVD-16*01)

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 (alternative)

<400>  26

Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
1               5                   10  


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Pro Thr Gln Pro Pro Asp Phe Ala Leu Ala 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Arg Asp His Gln Ile Pro Val Ile Ala Ala Asn 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr Gln 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Val Ser His Ser Ala Gln Pro Pro Ala His Gln 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Pro Leu Val Thr Thr Leu Gly Ala Gln Leu Pro 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Pro Ala His Gln Ile Ser Val Pro Ala Ala Thr 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  38

Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Pro Thr Leu Leu Pro Ser Gln Ser Pro Thr Asn Gln 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Pro His Ser Lys Ala Pro Gln Ile Pro Arg Glu Asp 
1               5                   10          


