                         SEQUENCE LISTING

<110>  Institut National de la Recherche Agronomique
 
<120>  Fusion protein comprising the N protein of a virus of the 
       Pneumovirinae subfamily

<130>  BET16P3621

<150>  EP 16305140.2
<151>  2016-02-05

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  391
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  1

Met Ala Leu Ser Lys Val Lys Leu Asn Asp Thr Leu Asn Lys Asp Gln 
1               5                   10                  15      


Leu Leu Ser Ser Ser Lys Tyr Thr Ile Gln Arg Ser Thr Gly Asp Ser 
            20                  25                  30          


Ile Asp Thr Pro Asn Tyr Asp Val Gln Lys His Ile Asn Lys Leu Cys 
        35                  40                  45              


Gly Met Leu Leu Ile Thr Glu Asp Ala Asn His Lys Phe Thr Gly Leu 
    50                  55                  60                  


Ile Gly Met Leu Tyr Ala Met Ser Arg Leu Gly Arg Glu Asp Thr Ile 
65                  70                  75                  80  


Lys Ile Leu Arg Asp Ala Gly Tyr His Val Lys Ala Asn Gly Val Asp 
                85                  90                  95      


Val Thr Thr His Arg Gln Asp Ile Asn Gly Lys Glu Met Lys Phe Glu 
            100                 105                 110         


Val Leu Thr Leu Ser Ser Leu Thr Thr Glu Ile Gln Ile Asn Ile Glu 
        115                 120                 125             


Ile Glu Ser Arg Lys Ser Tyr Lys Lys Met Leu Lys Glu Met Gly Glu 
    130                 135                 140                 


Val Ala Pro Glu Tyr Arg His Asp Ser Pro Asp Cys Gly Met Ile Ile 
145                 150                 155                 160 


Leu Cys Ile Ala Ala Leu Val Ile Thr Lys Leu Ala Ala Gly Asp Arg 
                165                 170                 175     


Ser Gly Leu Thr Ala Val Ile Arg Arg Ala Asn Asn Val Leu Lys Asn 
            180                 185                 190         


Glu Met Lys Arg Tyr Lys Gly Leu Leu Pro Lys Asp Ile Ala Asn Ser 
        195                 200                 205             


Phe Tyr Glu Val Phe Glu Lys Tyr Pro His Phe Ile Asp Val Phe Val 
    210                 215                 220                 


His Phe Gly Ile Ala Gln Ser Ser Thr Arg Gly Gly Ser Arg Val Glu 
225                 230                 235                 240 


Gly Ile Phe Ala Gly Leu Phe Met Asn Ala Tyr Gly Ala Gly Gln Val 
                245                 250                 255     


Met Leu Arg Trp Gly Val Leu Ala Lys Ser Val Lys Asn Ile Met Leu 
            260                 265                 270         


Gly His Ala Ser Val Gln Ala Glu Met Glu Gln Val Val Glu Val Tyr 
        275                 280                 285             


Glu Tyr Ala Gln Lys Leu Gly Gly Glu Ala Gly Phe Tyr His Ile Leu 
    290                 295                 300                 


Asn Asn Pro Lys Ala Ser Leu Leu Ser Leu Thr Gln Phe Pro His Phe 
305                 310                 315                 320 


Ser Ser Val Val Leu Gly Asn Ala Ala Gly Leu Gly Ile Met Gly Glu 
                325                 330                 335     


Tyr Arg Gly Thr Pro Arg Asn Gln Asp Leu Tyr Asp Ala Ala Lys Ala 
            340                 345                 350         


Tyr Ala Glu Gln Leu Lys Glu Asn Gly Val Ile Asn Tyr Ser Val Leu 
        355                 360                 365             


Asp Leu Thr Ala Glu Glu Leu Glu Ala Ile Lys His Gln Leu Asn Pro 
    370                 375                 380                 


Lys Asp Asn Asp Val Glu Leu 
385                 390     


<210>  2
<211>  391
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  2

Met Ala Leu Ser Lys Val Lys Leu Asn Asp Thr Phe Asn Lys Asp Gln 
1               5                   10                  15      


Leu Leu Ser Thr Ser Lys Tyr Thr Ile Gln Arg Ser Thr Gly Asp Asn 
            20                  25                  30          


Ile Asp Ile Pro Asn Tyr Asp Val Gln Lys His Leu Asn Lys Leu Cys 
        35                  40                  45              


Gly Met Leu Leu Ile Thr Glu Asp Ala Asn His Lys Phe Thr Gly Leu 
    50                  55                  60                  


Ile Gly Met Leu Tyr Ala Met Ser Arg Leu Gly Arg Glu Asp Thr Leu 
65                  70                  75                  80  


Lys Ile Leu Lys Asp Ala Gly Tyr Gln Val Arg Ala Asn Gly Val Asp 
                85                  90                  95      


Val Ile Thr His Arg Gln Asp Val Asn Gly Lys Glu Met Lys Phe Glu 
            100                 105                 110         


Val Leu Thr Leu Val Ser Leu Thr Ser Glu Val Gln Gly Asn Ile Glu 
        115                 120                 125             


Ile Glu Ser Arg Lys Ser Tyr Lys Lys Met Leu Lys Glu Met Gly Glu 
    130                 135                 140                 


Val Ala Pro Glu Tyr Arg His Asp Phe Pro Asp Cys Gly Met Ile Val 
145                 150                 155                 160 


Leu Cys Val Ala Ala Leu Val Ile Thr Lys Leu Ala Ala Gly Asp Arg 
                165                 170                 175     


Ser Gly Leu Thr Ala Val Ile Arg Arg Ala Asn Asn Val Leu Arg Asn 
            180                 185                 190         


Glu Met Lys Arg Tyr Lys Gly Leu Ile Pro Lys Asp Ile Ala Asn Ser 
        195                 200                 205             


Phe Tyr Glu Val Phe Glu Lys Tyr Pro His Tyr Ile Asp Val Phe Val 
    210                 215                 220                 


His Phe Gly Ile Ala Gln Ser Ser Thr Arg Gly Gly Ser Arg Val Glu 
225                 230                 235                 240 


Gly Ile Phe Ala Gly Leu Phe Met Asn Ala Tyr Gly Ala Gly Gln Val 
                245                 250                 255     


Met Leu Arg Trp Gly Val Leu Ala Lys Ser Val Lys Asn Ile Met Leu 
            260                 265                 270         


Gly His Ala Ser Val Gln Ala Glu Met Glu Gln Val Val Glu Val Tyr 
        275                 280                 285             


Glu Tyr Ala Gln Lys Leu Gly Gly Glu Ala Gly Phe Tyr His Ile Leu 
    290                 295                 300                 


Asn Asn Pro Lys Ala Ser Leu Leu Ser Leu Thr Gln Phe Pro Asn Phe 
305                 310                 315                 320 


Ser Ser Val Val Leu Gly Asn Ala Ala Gly Leu Gly Ile Met Gly Glu 
                325                 330                 335     


Tyr Arg Gly Thr Pro Arg Asn Gln Asp Leu Tyr Asp Ala Ala Lys Ala 
            340                 345                 350         


Tyr Ala Glu Gln Leu Lys Glu Asn Gly Val Ile Asn Tyr Ser Val Leu 
        355                 360                 365             


Asp Leu Thr Thr Glu Glu Leu Glu Ala Ile Lys Asn Gln Leu Asn Pro 
    370                 375                 380                 


Lys Asp Asn Asp Val Glu Leu 
385                 390     


<210>  3
<211>  394
<212>  PRT
<213>  Human Metapneumovirus

<400>  3

Met Ser Leu Gln Gly Ile His Leu Ser Asp Leu Ser Tyr Lys His Ala 
1               5                   10                  15      


Ile Leu Lys Glu Ser Gln Tyr Thr Ile Lys Arg Asp Val Gly Thr Thr 
            20                  25                  30          


Thr Ala Val Thr Pro Ser Ser Leu Gln Gln Glu Ile Thr Leu Leu Cys 
        35                  40                  45              


Gly Glu Ile Leu Tyr Ala Lys His Ala Asp Tyr Lys Tyr Ala Ala Glu 
    50                  55                  60                  


Ile Gly Ile Gln Tyr Ile Ser Thr Ala Leu Gly Ser Glu Arg Val Gln 
65                  70                  75                  80  


Gln Ile Leu Arg Asn Ser Gly Ser Glu Val Gln Val Val Leu Thr Arg 
                85                  90                  95      


Thr Tyr Ser Leu Gly Lys Ile Lys Asn Asn Lys Gly Glu Asp Leu Gln 
            100                 105                 110         


Met Leu Asp Ile His Gly Val Glu Lys Ser Trp Val Glu Glu Ile Asp 
        115                 120                 125             


Lys Glu Ala Arg Lys Thr Met Ala Thr Leu Leu Lys Glu Ser Ser Gly 
    130                 135                 140                 


Asn Ile Pro Gln Asn Gln Arg Pro Ser Ala Pro Asp Thr Pro Ile Ile 
145                 150                 155                 160 


Leu Leu Cys Val Gly Ala Leu Ile Phe Thr Lys Leu Ala Ser Thr Ile 
                165                 170                 175     


Glu Val Gly Leu Glu Thr Thr Val Arg Arg Ala Asn Arg Val Leu Ser 
            180                 185                 190         


Asp Ala Leu Lys Arg Tyr Pro Arg Met Asp Ile Pro Lys Ile Ala Arg 
        195                 200                 205             


Ser Phe Tyr Asp Leu Phe Glu Gln Lys Val Tyr His Arg Ser Leu Phe 
    210                 215                 220                 


Ile Glu Tyr Gly Lys Ala Leu Gly Ser Ser Ser Thr Gly Ser Lys Ala 
225                 230                 235                 240 


Glu Ser Leu Phe Val Asn Ile Phe Met Gln Ala Tyr Gly Ala Gly Gln 
                245                 250                 255     


Thr Met Leu Arg Trp Gly Val Ile Ala Arg Ser Ser Asn Asn Ile Met 
            260                 265                 270         


Leu Gly His Val Ser Val Gln Ala Glu Leu Lys Gln Val Thr Glu Val 
        275                 280                 285             


Tyr Asp Leu Val Arg Glu Met Gly Pro Glu Ser Gly Leu Leu His Leu 
    290                 295                 300                 


Arg Gln Ser Pro Lys Ala Gly Leu Leu Ser Leu Ala Asn Cys Pro Asn 
305                 310                 315                 320 


Phe Ala Ser Val Val Leu Gly Asn Ala Ser Gly Leu Gly Ile Ile Gly 
                325                 330                 335     


Met Tyr Arg Gly Arg Val Pro Asn Thr Glu Leu Phe Ser Ala Ala Glu 
            340                 345                 350         


Ser Tyr Ala Lys Ser Leu Lys Glu Ser Asn Lys Ile Asn Phe Ser Ser 
        355                 360                 365             


Leu Gly Leu Thr Asp Glu Glu Lys Glu Ala Ala Glu His Phe Leu Asn 
    370                 375                 380                 


Val Ser Asp Asp Ser Gln Asn Asp Tyr Glu 
385                 390                 


<210>  4
<211>  7
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  4

Asp Ile Asn Gly Lys Glu Met 
1               5           


<210>  5
<211>  21
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  5

Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln 
1               5                   10                  15      


Lys Lys Leu Met Ser 
            20      


<210>  6
<211>  38
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  6

Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
1               5                   10                  15      


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
            20                  25                  30          


Ile Val Arg Gln Gln Ser 
        35              


<210>  7
<211>  241
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  7

Met Glu Lys Phe Ala Pro Glu Phe His Gly Glu Asp Ala Asn Asn Arg 
1               5                   10                  15      


Ala Thr Lys Phe Leu Glu Ser Ile Lys Gly Lys Phe Thr Ser Pro Lys 
            20                  25                  30          


Asp Pro Lys Lys Lys Asp Ser Ile Ile Ser Val Asn Ser Thr Asp Ile 
        35                  40                  45              


Glu Val Thr Lys Glu Ser Pro Ile Thr Ser Asn Ser Thr Ile Ile Asn 
    50                  55                  60                  


Pro Thr Asn Glu Thr Asp Asp Asn Ala Gly Asn Lys Pro Asn Tyr Gln 
65                  70                  75                  80  


Arg Lys Pro Leu Val Ser Phe Lys Glu Asp Pro Ile Pro Ser Asp Asn 
                85                  90                  95      


Pro Phe Ser Lys Leu Tyr Lys Glu Thr Ile Glu Thr Phe Asp Asn Asn 
            100                 105                 110         


Glu Glu Glu Ser Ser Tyr Ser Tyr Glu Glu Ile Asn Asp Gln Thr Asn 
        115                 120                 125             


Asp Asn Ile Thr Ala Arg Leu Asp Arg Ile Asp Glu Lys Leu Ser Glu 
    130                 135                 140                 


Ile Leu Gly Met Leu His Thr Leu Val Val Ala Ser Ala Gly Pro Thr 
145                 150                 155                 160 


Ser Ala Arg Asp Gly Ile Arg Asp Ala Met Val Gly Leu Arg Glu Glu 
                165                 170                 175     


Met Ile Glu Lys Ile Arg Thr Glu Ala Leu Met Thr Asn Asp Arg Leu 
            180                 185                 190         


Glu Ala Met Ala Arg Leu Arg Asn Glu Glu Ser Glu Lys Met Ala Lys 
        195                 200                 205             


Asp Thr Ser Asp Glu Val Ser Leu Asn Pro Thr Ser Glu Lys Leu Asn 
    210                 215                 220                 


Asn Leu Leu Glu Gly Asn Asp Ser Asp Asn Asp Leu Ser Leu Glu Asp 
225                 230                 235                 240 


Phe 
    


<210>  8
<211>  241
<212>  PRT
<213>  Bovine respiratory syncytial virus

<400>  8

Met Glu Lys Phe Ala Pro Glu Phe His Gly Glu Asp Ala Asn Thr Lys 
1               5                   10                  15      


Ala Thr Lys Phe Leu Glu Ser Leu Lys Gly Lys Phe Thr Ser Ser Lys 
            20                  25                  30          


Asp Ser Arg Lys Lys Asp Ser Ile Ile Ser Val Asn Ser Ile Asp Ile 
        35                  40                  45              


Glu Leu Pro Lys Glu Ser Pro Ile Thr Ser Thr Asn His Asn Ile Asn 
    50                  55                  60                  


Gln Pro Ser Glu Ile Asn Asp Thr Ile Ala Ala Asn Gln Val His Ile 
65                  70                  75                  80  


Arg Lys Pro Leu Val Ser Phe Lys Glu Glu Leu Pro Ser Ser Glu Asn 
                85                  90                  95      


Pro Phe Thr Lys Leu Tyr Lys Glu Thr Ile Glu Thr Phe Asp Asn Asn 
            100                 105                 110         


Glu Glu Glu Ser Ser Tyr Ser Tyr Asp Glu Ile Asn Asp Gln Thr Asn 
        115                 120                 125             


Asp Asn Ile Thr Ala Arg Leu Asp Arg Ile Asp Glu Lys Leu Ser Glu 
    130                 135                 140                 


Ile Ile Gly Met Leu His Thr Leu Val Val Ala Ser Ala Gly Pro Thr 
145                 150                 155                 160 


Ala Ala Arg Asp Gly Ile Arg Asp Ala Met Val Gly Leu Arg Glu Glu 
                165                 170                 175     


Met Ile Glu Lys Ile Arg Ser Glu Ala Leu Met Thr Asn Asp Arg Leu 
            180                 185                 190         


Glu Ala Met Ala Arg Leu Arg Asp Glu Glu Ser Glu Lys Met Thr Lys 
        195                 200                 205             


Asp Thr Ser Asp Glu Val Lys Leu Thr Pro Thr Ser Glu Lys Leu Asn 
    210                 215                 220                 


Met Val Leu Glu Asp Glu Ser Ser Asp Asn Asp Leu Ser Leu Glu Asp 
225                 230                 235                 240 


Phe 
    


<210>  9
<211>  294
<212>  PRT
<213>  Human Metapneumovirus

<400>  9

Met Ser Phe Pro Glu Gly Lys Asp Ile Leu Phe Met Gly Asn Glu Ala 
1               5                   10                  15      


Ala Lys Leu Ala Glu Ala Phe Gln Lys Ser Leu Arg Lys Pro Gly His 
            20                  25                  30          


Lys Arg Ser Gln Ser Ile Ile Gly Glu Lys Val Asn Thr Val Ser Glu 
        35                  40                  45              


Thr Leu Glu Leu Pro Thr Ile Ser Arg Pro Ala Lys Pro Thr Ile Pro 
    50                  55                  60                  


Ser Glu Pro Lys Leu Ala Trp Thr Asp Lys Gly Gly Ala Thr Lys Thr 
65                  70                  75                  80  


Glu Ile Lys Gln Ala Ile Lys Val Met Asp Pro Ile Glu Glu Glu Glu 
                85                  90                  95      


Ser Thr Glu Lys Lys Val Leu Pro Ser Ser Asp Gly Lys Thr Pro Ala 
            100                 105                 110         


Glu Lys Lys Leu Lys Pro Ser Thr Asn Thr Lys Lys Lys Val Ser Phe 
        115                 120                 125             


Thr Pro Asn Glu Pro Gly Lys Tyr Thr Lys Leu Glu Lys Asp Ala Leu 
    130                 135                 140                 


Asp Leu Leu Ser Asp Asn Glu Glu Glu Asp Ala Glu Ser Ser Ile Leu 
145                 150                 155                 160 


Thr Phe Glu Glu Arg Asp Thr Ser Ser Leu Ser Ile Glu Ala Arg Leu 
                165                 170                 175     


Glu Ser Ile Glu Glu Lys Leu Ser Met Ile Leu Gly Leu Leu Arg Thr 
            180                 185                 190         


Leu Asn Ile Ala Thr Ala Gly Pro Thr Ala Ala Arg Asp Gly Ile Arg 
        195                 200                 205             


Asp Ala Met Ile Gly Val Arg Glu Glu Leu Ile Ala Asp Ile Ile Lys 
    210                 215                 220                 


Glu Ala Lys Gly Lys Ala Ala Glu Met Met Glu Glu Glu Met Ser Gln 
225                 230                 235                 240 


Arg Ser Lys Ile Gly Asn Gly Ser Val Lys Leu Thr Glu Lys Ala Lys 
                245                 250                 255     


Glu Leu Asn Lys Ile Val Glu Asp Glu Ser Thr Ser Gly Glu Ser Glu 
            260                 265                 270         


Glu Glu Glu Glu Pro Lys Asp Thr Gln Asp Asn Ser Gln Glu Asp Asp 
        275                 280                 285             


Ile Tyr Gln Leu Ile Met 
    290                 


