                         SEQUENCE LISTING

<110>  PolyGene AG
 
<120>  GLUCOCORTICOID-BASED GENE REGULATION SYSTEM

<130>  P5083PC00

<150>  EP16154365.7
<151>  2016-02-05

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAL4 mut6

<400>  1

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Asp Gln Glu Phe Pro Ser Cys Lys Arg Cys Ala 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu 
                85                  90          


<210>  2
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cs1/CD 524-795

<400>  2

Ala Gly Val Ser Gln Asp Thr Ser Glu Asn Pro Asn Lys Thr Ile Val 
1               5                   10                  15      


Pro Ala Ala Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu 
            20                  25                  30          


Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro 
        35                  40                  45              


Asp Ser Ala Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg 
    50                  55                  60                  


Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg 
65                  70                  75                  80  


Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met 
                85                  90                  95      


Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser 
            100                 105                 110         


Gly Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg 
        115                 120                 125             


Met Ser Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Phe Val 
    130                 135                 140                 


Ser Ser Glu Leu Gln Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys 
145                 150                 155                 160 


Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Glu Gly Leu Lys 
                165                 170                 175     


Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu 
            180                 185                 190         


Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln 
        195                 200                 205             


Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val 
    210                 215                 220                 


Glu Asn Leu Leu Thr Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met 
225                 230                 235                 240 


Ser Ile Glu Phe Pro Glu Ala Ala Ala Glu Ile Ile Thr Asn Gln Ile 
                245                 250                 255     


Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys Ala 
            260                 265                 270     


<210>  3
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cs1/CD 504-795

<400>  3

Pro Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys Ile Lys 
1               5                   10                  15      


Gly Ile Gln Gln Ala Thr Ala Gly Val Ser Gln Asp Thr Ser Glu Asn 
            20                  25                  30          


Pro Asn Lys Thr Ile Val Pro Ala Ala Leu Pro Gln Leu Thr Pro Thr 
        35                  40                  45              


Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly 
    50                  55                  60                  


Tyr Asp Ser Ser Val Pro Asp Ser Ala Trp Arg Ile Met Thr Thr Leu 
65                  70                  75                  80  


Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys 
                85                  90                  95      


Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu 
            100                 105                 110         


Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg 
        115                 120                 125             


Ser Tyr Arg Gln Ser Ser Gly Asn Leu Leu Cys Phe Ala Pro Asp Leu 
    130                 135                 140                 


Ile Ile Asn Glu Gln Arg Met Ser Leu Pro Cys Met Tyr Asp Gln Cys 
145                 150                 155                 160 


Lys His Met Leu Phe Val Ser Ser Glu Leu Gln Arg Leu Gln Val Ser 
                165                 170                 175     


Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val 
            180                 185                 190         


Pro Lys Glu Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met 
        195                 200                 205             


Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn 
    210                 215                 220                 


Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
225                 230                 235                 240 


Ser Met His Glu Val Val Glu Asn Leu Leu Thr Tyr Cys Phe Gln Thr 
                245                 250                 255     


Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Ala Ala Ala Glu 
            260                 265                 270         


Ile Ile Thr Asn Gln Ile Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu 
        275                 280                 285             


Phe His Gln Lys Ala 
    290             


<210>  4
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cs1/CD 540-795

<400>  4

Pro Ala Ala Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu 
1               5                   10                  15      


Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro 
            20                  25                  30          


Asp Ser Ala Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg 
        35                  40                  45              


Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg 
    50                  55                  60                  


Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met 
65                  70                  75                  80  


Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser 
                85                  90                  95      


Gly Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg 
            100                 105                 110         


Met Ser Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Phe Val 
        115                 120                 125             


Ser Ser Glu Leu Gln Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys 
    130                 135                 140                 


Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Glu Gly Leu Lys 
145                 150                 155                 160 


Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu 
                165                 170                 175     


Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln 
            180                 185                 190         


Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val 
        195                 200                 205             


Glu Asn Leu Leu Thr Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met 
    210                 215                 220                 


Ser Ile Glu Phe Pro Glu Ala Ala Ala Glu Ile Ile Thr Asn Gln Ile 
225                 230                 235                 240 


Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys Ala 
                245                 250                 255 


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5
ggggsggggs ggggstgyka ggggsggggs ggggs                                  35


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6
ggggsggggs ggggs                                                        15


<210>  7
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA97.87

<400>  7

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ala Gln Glu Phe Pro Ser Cys Lys Arg Cys Ala 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Gly Ala Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly 
            100                 105                 110         


Tyr Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Thr Gly Thr Met Leu Gly Thr Pro Ala Gly Met Asn Leu Glu 
    130                 135                 140                 


Ala Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Ala 
145                 150                 155                 160 


Gly Val Ser Gln Asp Thr Ser Glu Asn Pro Asn Lys Thr Ile Val Pro 
                165                 170                 175     


Ala Ala Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val 
            180                 185                 190         


Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp 
        195                 200                 205             


Ser Ala Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln 
    210                 215                 220                 


Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn 
225                 230                 235                 240 


Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe 
                245                 250                 255     


Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Gly 
            260                 265                 270         


Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met 
        275                 280                 285             


Ser Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Phe Val Ser 
    290                 295                 300                 


Ser Glu Leu Gln Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met 
305                 310                 315                 320 


Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Glu Gly Leu Lys Ser 
                325                 330                 335     


Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly 
            340                 345                 350         


Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg 
        355                 360                 365             


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val Glu 
    370                 375                 380                 


Asn Leu Leu Thr Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser 
385                 390                 395                 400 


Ile Glu Phe Pro Glu Ala Ala Ala Glu Ile Ile Thr Asn Gln Ile Tyr 
                405                 410                 415     


Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys Ala Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Thr 
        435                 440                 445             


Pro Ala Ala Ala Ser Thr Gln Phe Pro Gly Ile Trp Ala Pro Pro Thr 
    450                 455                 460                 


Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala 
465                 470                 475                 480 


Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
                485                 490                 495     


Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro 
            500                 505                 510         


Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr 
        515                 520                 525             


Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
    530                 535             


<210>  8
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gal4 mut7

<400>  8

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ala Gln Glu Phe Pro Ser Cys Lys Arg Cys Ala 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu 
                85                  90          


<210>  9
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA97.75

<400>  9

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Asp Gln Glu Phe Pro Ser Cys Lys Arg Cys Ala 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Gly Ala Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly 
            100                 105                 110         


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
    130                 135                 140                 


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Gly 
145                 150                 155                 160 


Thr Met Leu Gly Thr Pro Ala Ala Leu Pro Gln Leu Thr Pro Thr Leu 
                165                 170                 175     


Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr 
            180                 185                 190         


Asp Ser Ser Val Pro Asp Ser Ala Trp Arg Ile Met Thr Thr Leu Asn 
        195                 200                 205             


Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala 
    210                 215                 220                 


Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu 
225                 230                 235                 240 


Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser 
                245                 250                 255     


Tyr Arg Gln Ser Ser Gly Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile 
            260                 265                 270         


Ile Asn Glu Gln Arg Met Ser Leu Pro Cys Met Tyr Asp Gln Cys Lys 
        275                 280                 285             


His Met Leu Phe Val Ser Ser Glu Leu Gln Arg Leu Gln Val Ser Tyr 
    290                 295                 300                 


Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro 
305                 310                 315                 320 


Lys Glu Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr 
                325                 330                 335     


Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser 
            340                 345                 350         


Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
        355                 360                 365             


Met His Glu Val Val Glu Asn Leu Leu Thr Tyr Cys Phe Gln Thr Phe 
    370                 375                 380                 


Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Ala Ala Ala Glu Ile 
385                 390                 395                 400 


Ile Thr Asn Gln Ile Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe 
                405                 410                 415     


His Gln Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Ala Gly Thr Pro Ala Ala Ala Ser Thr Gln Phe Pro Gly 
        435                 440                 445             


Ile Trp Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu 
    450                 455                 460                 


Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe 
465                 470                 475                 480 


Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr 
                485                 490                 495     


Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu 
            500                 505                 510         


Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
        515                 520                 525             


<210>  10
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA97.76

<400>  10

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ala Gln Glu Phe Pro Ser Cys Lys Arg Cys Ala 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Gly Ala Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly 
            100                 105                 110         


Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
    130                 135                 140                 


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Gly 
145                 150                 155                 160 


Thr Met Leu Gly Thr Pro Ala Ala Leu Pro Gln Leu Thr Pro Thr Leu 
                165                 170                 175     


Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr 
            180                 185                 190         


Asp Ser Ser Val Pro Asp Ser Ala Trp Arg Ile Met Thr Thr Leu Asn 
        195                 200                 205             


Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala 
    210                 215                 220                 


Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu 
225                 230                 235                 240 


Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser 
                245                 250                 255     


Tyr Arg Gln Ser Ser Gly Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile 
            260                 265                 270         


Ile Asn Glu Gln Arg Met Ser Leu Pro Cys Met Tyr Asp Gln Cys Lys 
        275                 280                 285             


His Met Leu Phe Val Ser Ser Glu Leu Gln Arg Leu Gln Val Ser Tyr 
    290                 295                 300                 


Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro 
305                 310                 315                 320 


Lys Glu Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr 
                325                 330                 335     


Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser 
            340                 345                 350         


Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
        355                 360                 365             


Met His Glu Val Val Glu Asn Leu Leu Thr Tyr Cys Phe Gln Thr Phe 
    370                 375                 380                 


Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Ala Ala Ala Glu Ile 
385                 390                 395                 400 


Ile Thr Asn Gln Ile Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe 
                405                 410                 415     


His Gln Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Ala Gly Thr Pro Ala Ala Ala Ser Thr Gln Phe Pro Gly 
        435                 440                 445             


Ile Trp Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu 
    450                 455                 460                 


Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe 
465                 470                 475                 480 


Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr 
                485                 490                 495     


Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu 
            500                 505                 510         


Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
        515                 520                 525             


<210>  11
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP16 transactivation domain

<400>  11

Ala Gly Thr Pro Ala Ala Ala Ser Thr Gln Phe Pro Gly Ile Trp Ala 
1               5                   10                  15      


Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu 
            20                  25                  30          


Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp 
    50                  55                  60                  


Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln 
65                  70                  75                  80  


Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                85                  90              


<210>  12
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mphR(A)

<400>  12

Met Pro Arg Pro Lys Leu Lys Ser Asp Asp Glu Val Leu Glu Ala Ala 
1               5                   10                  15      


Thr Val Val Leu Lys Arg Cys Gly Pro Ile Glu Phe Thr Leu Ser Gly 
            20                  25                  30          


Val Ala Lys Glu Val Gly Leu Ser Arg Ala Ala Leu Ile Gln Arg Phe 
        35                  40                  45              


Thr Asn Arg Asp Thr Leu Leu Val Arg Met Met Glu Arg Gly Val Glu 
    50                  55                  60                  


Gln Val Arg His Tyr Leu Asn Ala Ile Pro Ile Gly Ala Gly Pro Gln 
65                  70                  75                  80  


Gly Leu Trp Glu Phe Leu Gln Val Leu Val Arg Ser Met Asn Thr Arg 
                85                  90                  95      


Asn Asp Phe Ser Val Asn Tyr Leu Ile Ser Trp Tyr Glu Leu Gln Val 
            100                 105                 110         


Pro Glu Leu Arg Thr Leu Ala Ile Gln Arg Asn Arg Ala Val Val Glu 
        115                 120                 125             


Gly Ile Arg Lys Arg Leu Pro Pro Gly Ala Pro Ala Ala Ala Glu Leu 
    130                 135                 140                 


Leu Leu His Ser Val Ile Ala Gly Ala Thr Met Gln Trp Ala Val Asp 
145                 150                 155                 160 


Pro Asp Gly Glu Leu Ala Asp His Val Leu Ala Gln Ile Ala Ala Ile 
                165                 170                 175     


Leu Cys Leu Met Phe Pro Glu His Asp Asp Phe Gln Leu Leu Gln Ala 
            180                 185                 190         


His Ala 
        


<210>  13
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB

<400>  13

Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His 
65                  70                  75                  80  


Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser 
                85                  90                  95      


Val Ser Ser Arg Ser Ile Phe Lys Asp Lys Gln Ser Cys Asp Ile Lys 
            100                 105                 110         


Met Glu Gly Met Ala Arg Asn Asp Leu Trp Ala Gly 
        115                 120                 


<210>  14
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40

<400>  14
atcgataagc tagcttggct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc       60

tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga      120

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca      180

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat      240

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc      300

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag      360

ctcctcgagg aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta      420

tttcaggtcc cggatcggaa t                                                441


<210>  15
<211>  557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV

<400>  15
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcg cctggtaata      540

cgactcacta tagggac                                                     557


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PETR1

<400>  16
ttgaatataa ccgacgtgac tgttacattt a                                      31


<210>  17
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PETR2


<220>
<221>  PETR2
<222>  (32)..(32)
<223>  at least three nucleotides are present

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is a, c, g, or t

<400>  17
ttgaatataa ccgacgtgac tgttacattt anttgaatat aaccgacgtg actgttacat       60

tta                                                                     63


<210>  18
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PETR8

<400>  18
taaacgattg aatataaccg acgtgactgt tacatttagg gattgaatat aaccgacgtg       60

actgttacat ttagggattg aatataaccg acgtgactgt tacatttagg gattgaatat      120

aaccgacgtg actgttacat ttagggataa acgattgaat ataaccgacg tgactgttac      180

atttagggat tgaatataac cgacgtgact gttacattta gggattgaat ataaccgacg      240

tgactgttac atttagggat tgaatataac cgacgtgact gttacattta gggatat         297


<210>  19
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ttgR

<400>  19

Met Val Arg Arg Thr Lys Glu Glu Ala Gln Glu Thr Arg Ala Gln Ile 
1               5                   10                  15      


Ile Glu Ala Ala Glu Arg Ala Phe Tyr Lys Arg Gly Val Ala Arg Thr 
            20                  25                  30          


Thr Leu Ala Asp Ile Ala Glu Leu Ala Gly Val Thr Arg Gly Ala Ile 
        35                  40                  45              


Tyr Trp His Phe Asn Asn Lys Ala Glu Leu Val Gln Ala Leu Leu Asp 
    50                  55                  60                  


Ser Leu His Glu Thr His Asp His Leu Ala Arg Ala Ser Glu Ser Glu 
65                  70                  75                  80  


Asp Glu Val Asp Pro Leu Gly Cys Met Arg Lys Leu Leu Leu Gln Val 
                85                  90                  95      


Phe Asn Glu Leu Val Leu Asp Ala Arg Thr Arg Arg Ile Asn Glu Ile 
            100                 105                 110         


Leu His His Lys Cys Glu Phe Thr Asp Asp Met Cys Glu Ile Arg Gln 
        115                 120                 125             


Gln Arg Gln Ser Ala Val Leu Asp Cys His Lys Gly Ile Thr Leu Ala 
    130                 135                 140                 


Leu Ala Asn Ala Val Arg Arg Gly Gln Leu Pro Gly Glu Leu Asp Ala 
145                 150                 155                 160 


Glu Arg Ala Ala Val Ala Met Phe Ala Tyr Val Asp Gly Leu Ile Arg 
                165                 170                 175     


Arg Trp Leu Leu Leu Pro Asp Ser Val Asp Leu Leu Gly Asp Val Glu 
            180                 185                 190         


Lys Trp Val Asp Thr Gly Leu Asp Met Leu Arg Leu Ser Pro Ala Leu 
        195                 200                 205             


Arg Lys 
    210 


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Phlo-Op(1)

<400>  20
tatttacaaa caaccatgaa tgtaagta                                          28


<210>  21
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Phlo-Op(2)

<400>  21
cagtatttac aaacaaccat gaatgtaagt atattc                                 36


<210>  22
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR

<400>  22

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tet-Op

<400>  23
tccctatcag tgatagaga                                                    19


<210>  24
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PIP

<400>  24

Met Met Ser Arg Gly Glu Val Arg Met Ala Lys Ala Gly Arg Glu Gly 
1               5                   10                  15      


Pro Arg Asp Ser Val Trp Leu Ser Gly Glu Gly Arg Arg Gly Gly Arg 
            20                  25                  30          


Arg Gly Arg Gln Pro Ser Gly Leu Asp Arg Asp Arg Ile Thr Gly Val 
        35                  40                  45              


Thr Val Arg Leu Leu Asp Thr Glu Gly Leu Thr Gly Phe Ser Met His 
    50                  55                  60                  


Arg Leu Ala Ala Glu Leu Asn Val Thr Ala Met Ser Val Tyr Trp Tyr 
65                  70                  75                  80  


Val Asp Thr Lys Asp Gln Leu Leu Glu Leu Ala Leu Asp Ala Val Phe 
                85                  90                  95      


Gly Glu Leu Arg His Pro Asp Pro Asp Ala Gly Leu Asp Trp Arg Glu 
            100                 105                 110         


Glu Leu Arg Ala Leu Ala Arg Glu Asn Arg Ala Leu Leu Val Arg His 
        115                 120                 125             


Pro Trp Ser Ser Arg Leu Val Gly Thr Tyr Leu Asn Ile Gly Pro His 
    130                 135                 140                 


Ser Leu Ala Phe Ser Arg Ala Val Gln Asn Val Val Arg Arg Ser Gly 
145                 150                 155                 160 


Leu Pro Ala His Arg Leu Thr Gly Ala Ile Ser Ala Val Phe Gln Phe 
                165                 170                 175     


Val Tyr Gly Tyr Gly Thr Ile Glu Gly Arg Phe Leu Ala Arg Val Ala 
            180                 185                 190         


Asp Thr Gly Leu Ser Pro Glu Glu Tyr Phe Gln Asp Ser Met Thr Ala 
        195                 200                 205             


Val Thr Glu Val Pro Asp Thr Ala Gly Val Ile Glu Asp Ala Gln Asp 
    210                 215                 220                 


Ile Met Ala Ala Arg Gly Gly Asp Thr Val Ala Glu Met Leu Asp Arg 
225                 230                 235                 240 


Asp Phe Glu Phe Ala Leu Asp Leu Leu Val Ala Gly Ile Asp Ala Met 
                245                 250                 255     


Val Glu Gln Ala 
            260 


<210>  25
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pip Op(1)

<400>  25
gtacggtgta cgggaagata ctcgtacacc gtacaagaga ttcccatacg ctgtacagcg       60

ctatttcg                                                                68


<210>  26
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pip Op(2)

<400>  26
cgaaatagcg ctgtacagcg tatgggaatc tcttgtacgg tgtacgagta tcttcccgta       60

caccgtac                                                                68


<210>  27
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA97.85

<400>  27

Met Pro Arg Pro Lys Leu Lys Ser Asp Asp Glu Val Leu Glu Ala Ala 
1               5                   10                  15      


Thr Val Val Leu Lys Arg Cys Gly Pro Ile Glu Phe Thr Leu Ser Gly 
            20                  25                  30          


Val Ala Lys Glu Val Gly Leu Ser Arg Ala Ala Leu Ile Gln Arg Phe 
        35                  40                  45              


Thr Asn Arg Asp Thr Leu Leu Val Arg Met Met Glu Arg Gly Val Glu 
    50                  55                  60                  


Gln Val Arg His Tyr Leu Asn Ala Ile Pro Ile Gly Ala Gly Pro Gln 
65                  70                  75                  80  


Gly Leu Trp Glu Phe Leu Gln Val Leu Val Arg Ser Met Asn Thr Arg 
                85                  90                  95      


Asn Asp Phe Ser Val Asn Tyr Leu Ile Ser Trp Tyr Glu Leu Gln Val 
            100                 105                 110         


Pro Glu Leu Arg Thr Leu Ala Ile Gln Arg Asn Arg Ala Val Val Glu 
        115                 120                 125             


Gly Ile Arg Lys Arg Leu Pro Pro Gly Ala Pro Ala Ala Ala Glu Leu 
    130                 135                 140                 


Leu Leu His Ser Val Ile Ala Gly Ala Thr Met Gln Trp Ala Val Asp 
145                 150                 155                 160 


Pro Asp Gly Glu Leu Ala Asp His Val Leu Ala Gln Ile Ala Ala Ile 
                165                 170                 175     


Leu Cys Leu Met Phe Pro Glu His Asp Asp Phe Gln Leu Leu Gln Ala 
            180                 185                 190         


His Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Thr Gly Thr Met Leu Gly Thr Tyr Lys Ala Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Thr Met Leu 
225                 230                 235                 240 


Gly Thr Pro Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                245                 250                 255     


Ile Lys Gly Ile Gln Gln Ala Thr Ala Gly Val Ser Gln Asp Thr Ser 
            260                 265                 270         


Glu Asn Pro Asn Lys Thr Ile Val Pro Ala Ala Leu Pro Gln Leu Thr 
        275                 280                 285             


Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr 
    290                 295                 300                 


Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Ala Trp Arg Ile Met Thr 
305                 310                 315                 320 


Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp 
                325                 330                 335     


Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met 
            340                 345                 350         


Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly 
        355                 360                 365             


Trp Arg Ser Tyr Arg Gln Ser Ser Gly Asn Leu Leu Cys Phe Ala Pro 
    370                 375                 380                 


Asp Leu Ile Ile Asn Glu Gln Arg Met Ser Leu Pro Cys Met Tyr Asp 
385                 390                 395                 400 


Gln Cys Lys His Met Leu Phe Val Ser Ser Glu Leu Gln Arg Leu Gln 
                405                 410                 415     


Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser 
            420                 425                 430         


Ser Val Pro Lys Glu Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile 
        435                 440                 445             


Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu 
    450                 455                 460                 


Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu 
465                 470                 475                 480 


Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Thr Tyr Cys Phe 
                485                 490                 495     


Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Ala Ala 
            500                 505                 510         


Ala Glu Ile Ile Thr Asn Gln Ile Tyr Ser Asn Gly Asn Ile Lys Lys 
        515                 520                 525             


Leu Leu Phe His Gln Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Ala Gly Thr Met Asp Ala Lys Ser Leu Thr 
545                 550                 555                 560 


Ala Trp Ser Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe 
                565                 570                 575     


Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr 
            580                 585                 590         


Arg Asn Val Met Leu Glu Asn Tyr Ser Cys Asp Ile Lys Met Glu Gly 
        595                 600                 605             


Met Ala Arg Asn Asp Leu Trp Ala Gly 
    610                 615         


