                         SEQUENCE LISTING

<110>  ALEXION PHARMACEUTICALS, INC.
 
<120>  ENZYME REPLACEMENT THERAPY IN MUCOPOLYSACCHARIDOSIS IIIB PATIENTS

<130>  0398 WO

<150>  US 62/289044
<151>  2016-01-29

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  743
<212>  PRT
<213>  Human

<400>  1

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  2
<211>  2234
<212>  DNA
<213>  Human

<400>  2
atggaggcgg tggcggtggc cgcggcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgaggcccg ggaggcggcg gccgtgcggg cgctcgtggc ccggctgctg      120

gggccaggcc ccgcggccga cttctccgtg tcggtggagc gcgctctggc tgccaagccg      180

ggcttggaca cctacagcct gggcggcggc ggcgcggcgc gcgtgcgggt gcgcggctcc      240

acgggcgtgg cagccgccgc ggggctgcac cgctacctgc gcgacttctg tggctgccac      300

gtggcctggt ccggctctca gctgcgcctg ccgcggccac tgccagccgt gccgggggag      360

ctgaccgagg ccacgcccaa caggtaccgc tattaccaga atgtgtgcac gcaaagctac      420

tctttcgtgt ggtgggactg ggcccggtgg gagcgagaga tagactggat ggcgctgaat      480

ggcatcaacc tggcactggc atggagcggc caggaggcca tctggcagcg ggtgtacctg      540

gccttgggcc tgacccaggc agagatcaat gagttcttta ctggtcctgc cttcttggca      600

tgggggcgaa tgggcaacct gcacacctgg gatggccccc tgcccccctc ctggcacatc      660

aagcagcttt atctgcagca ccgggtcctg gaccagatgc gctccttcgg catgacccca      720

gtgctgcctg cattcgcggg gcatgttccc gaggctgtca ccagggtgtt ccctcaggtc      780

aatgtcacga agatgggcag ttggggccac tttaactgtt cctactcctg ctccttcctt      840

ctggctccgg aagaccccat attccccatc atcgggagcc tcttcttgcg agagctgatc      900

aaagagtttg gcacagacca catctatggg gccgacactt tcaatgagat gcagccacct      960

tcctcagagc cctcctatct tgccgcagcc accactgccg tctatgaggc catgactgca     1020

gtggatactg aggctgtgtg gctgctccaa ggctggctct tccagcacca gccgcagttc     1080

tgggggcccg cccagatcag ggctgtgctg ggagctgtgc cccgtggccg cctcctggtt     1140

ctggacctgt ttgctgagag ccagcctgtg tatacccgca ctgcctcctt ccaaggccag     1200

cccttcatct ggtgcatgct gcacaacttt gggggaaatc atggtctttt tggagccttg     1260

gaggccgtga acggaggccc agaagctgcc cgcctcttcc ccaactccac aatggtaggc     1320

acgggcatgg cccccgaggg catcagccag aacgaagtgg tctattccct catggctgag     1380

ctgggctggc gaaaggaccc agtgccagat ttggcagcct gggtgaccag ctttgccgcc     1440

cggcggtatg gggtctccca cccggacgca ggggcagcgt ggaggctact gctccggagt     1500

gtgtacaact gctccgggga ggcatgcagg ggccacaatc gtagcccgct ggtcaggcgg     1560

ccgtccctac agatgaatac cagcatctgg tacaaccgat ctgatgtgtt tgaggcctgg     1620

cggctgctgc tcacatctgc tccctccctg gccaccagcc ccgccttccg ctacgacctg     1680

ctggacctca ctcggcaggc agtgcaggag ctggtcagct tgtattatga ggaggcaaga     1740

agcgcctatc tgagcaagga gctggcctcc ttgttgaggg ctggaggcgt cctggcctat     1800

gagctgctgc cggcactgga cgaggtgctg gctagtgaca gccgcttctt gctgggcagc     1860

tggctagagc aggcccgagc agcggcagtc agtgaggccg aggccgattt ctacgagcag     1920

aacagccgct accagctgac cttgtggggg ccagaaggca acatcctgga ctatgccaac     1980

aagcagctgg cggggttggt ggccaactac tacacccctc gctggcggct tttcctggag     2040

gcgctggttg acagtgtggc ccagggcatc cctttccaac agcaccagtt tgacaaaaat     2100

gtcttccaac tggagcaggc cttcgttctc agcaagcaga ggtaccccag ccagccgcga     2160

ggagacactg tggacctggc caagaagatc ttcctcaaat attacccccg ctgggtggcc     2220

ggctcttggt gatt                                                       2234


<210>  3
<211>  1132
<212>  DNA
<213>  Chicken

<400>  3
gttaagtcct cagacttggc aaggagaatg tagatttcca cagtatatat gttttcacaa       60

aaggaaggag agaaacaaaa gaaaatggca ctgactaaac ttcagctagt ggtataggaa      120

agtaattctg cttaacagag attgcagtga tctctatgta tgtcctgaag aattatgttg      180

tacttttttc ccccattttt aaatcaaaca gtgctttaca gaggtcagaa tggtttcttt      240

actgtttgtc aattctatta tttcaataca gaacaatagc ttctataact gaaatatatt      300

tgctattgta tattatgatt gtccctcgaa ccatgaacac tcctccagct gaatttcaca      360

attcctctgt catctgccag gccattaagt tattcatgga agatctttga ggaacactgc      420

aagttcatat cataaacaca tttgaaattg agtattgttt tgcattgtat ggagctatgt      480

tttgctgtat cctcagaata aaagtttgtt ataaagcatt cacacccata aaaagataga      540

tttaaatatt ccaactatag gaaagaaagt gtgtctgctc ttcactctag tctcagttgg      600

ctccttcaca tgcacgcttc tttatttctc ctattttgtc aagaaaataa taggtcaagt      660

cttgttctca tttatgtcct gtctagcgtg gctcagatgc acattgtaca tacaagaagg      720

atcaaatgaa acagacttct ggtctgttac tacaaccata gtaataagca cactaactaa      780

taattgctaa ttatgttttc catctccaag gttcccacat ttttctgttt tcttaaagat      840

cccattatct ggttgtaact gaagctcaat ggaacatgag caatatttcc cagtcttctc      900

tcccatccaa cagtcctgat ggattagcag aacaggcaga aaacacattg ttacccagaa      960

ttaaaaacta atatttgctc tccattcaat ccaaaatgga cctattgaaa ctaaaatcta     1020

acccaatccc attaaatgat ttctatggtg tcaaaggtca aacttctgaa gggaacctgt     1080

gggtgggtca caattcagac tatatattcc ccagggctca gccagtgtct gt             1132


<210>  4
<211>  10256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-OV-1.1-I-rhNaGlu

<400>  4
ggccgcaaga agaaagctga aaaactctgt cccttccaac aagacccaga gcactgtagt       60

atcaggggta aaatgaaaag tatgttatct gctgcatcca gacttcataa aagctggagc      120

ttaattcaga aaaaaaatca gaaagaaatt acactgtgag aacaggtgca attcactttt      180

cctttacaca gagtaatact ggtaactcat ggatgaaggc ttaagggaat gaaattggac      240

tcacagtact gagtcatcac actgaaaaat gcaacctgat acatcagcag aaggtttatg      300

ggggaaaaat gcagccttcc aattaagcca gatatctgta tgaccaagct gctccagaat      360

tagtcactca aaatctctca gattaaatta tcaactgtca ccaaccattc ctatgctgac      420

aaggcaattg cttgttctct gtgttcctga tactacaagg ctcttcctga cttcctaaag      480

atgcattata aaaatcttat aattcacatt tctccctaaa ctttgactca atcatggtat      540

gttggcaaat atggtatatt actattcaaa ttgttttcct tgtacccata tgtaatgggt      600

cttgtgaatg tgctcttttg ttcctttaat cataataaaa acatgtttaa gcaaacactt      660

ttcacttgta gtatttgaag gtaccggatc tcgagccgcc ttcaatgccc ccaaaaccaa      720

tccccaggtt tttaactctc ccgattttcc aagtaccata gcccgctgag agagcgccgc      780

ggtaatggga tcccaggacc ccggggaata taagtctgag ggggacgtaa gcaacccttc      840

cttttgtaac agggacaaca tagcccctat ttccttctta gaaggagagg ttttcccgca      900

ataggtctta cacgcggacg aaatcacctt tatgacggct tccatgcttg atccaccggg      960

cgaccggaat cacgcagagc aaccggaatc acgcctgggg tggaccgctc agtcgtcggg     1020

cttccttccc gtcttccaac gactctctga gttctcggta gggtatgttg gccccctgca     1080

gtagggctcc ctccgacgcc actcagcttc tgccctccta agccgcagcc ccctctacta     1140

gggtcatcgt ccgctccccg aataagcgag acggatgagg acaggatcgc cacgccgcct     1200

gtggccgacc actattccct aacgatcacg tcggggtcac caaatgaagc cttctgcttc     1260

atgcatgtgc tcgtagtcgt cagggaatca acggtccggc catcaaccca ggtgcacacc     1320

aatgtggtga atggtcaaat ggcgtttatt gtatcgagct aggcacttaa atacaatatc     1380

tctgcaatgc ggaattcagt ggttcgtcca atccgtgtta gacccgtctg ttgccttcct     1440

aacaaggcac gatcatacca cgatcatacc accttactcc caccaatcgg catgcacggt     1500

gctttttctc tccttataag gcatgttgct aactcatcgt tacataagca tgttgcaaga     1560

ctacaagagt attgcataag actacatttc cccctcccta tgcaaaagcg aaactactat     1620

atcctgaggg gactcctaac cgcgtacaac cgaagccccg cttttcgcct aaacatgcta     1680

ttgtcccctc agtcaagcct tgcccgttac aacccgattc gcaagccttg ccctccccac     1740

attatccgta gcattatttc ctagcagtca tcagagctac agaagatact ctatgctgta     1800

gccaagtcta caagtttact attcagcgac ctcctatatt ccgcgtgcca gccgatcaat     1860

taccaatgcg cgcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     1920

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     1980

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     2040

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     2100

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     2160

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     2220

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     2280

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     2340

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     2400

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     2460

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     2520

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     2580

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     2640

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     2700

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa     2760

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     2820

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     2880

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     2940

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     3000

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     3060

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     3120

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     3180

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     3240

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     3300

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     3360

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     3420

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     3480

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     3540

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     3600

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     3660

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     3720

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     3780

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     3840

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     3900

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     3960

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     4020

tccccgaaaa gtgccacctg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt     4080

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt     4140

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     4200

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg     4260

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     4320

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc     4380

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga     4440

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta caatttccat     4500

tcgccattca ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta     4560

cgccagctgg cgaaaggggg atgtgctgca aggcgattaa gttgggtaac gccagggttt     4620

tcccagtcac gacgttgtaa aacgacggcc agtgagcgcg tattccctaa cgatcacgtc     4680

ggggtcacca aatgaagcct tctgcttcat gcatgtgctc gtagtcgtca gggaatcaac     4740

ggtccggcca tcaacccagg tgcacaccaa tgtggtgaat ggtcaaatgg cgtttattgt     4800

atcgagctag gcacttaaat acaatatctc tgcaatgcgg aattcagtgg ttcgtccaat     4860

ccgtccccct ccctatgcaa aagcgaaact actatatcct gaggggactc ctaaccgcgt     4920

acaaccgaag ccccgctttt cgcctaaaca tgctattgtc ccctcagtca agccttgccc     4980

gttacaaccc gattcgcaag ccttgccctc cccacattat ccgtagcatt atttcctagc     5040

agtcatcaga gctacagaag atactctatg ctgtagccaa gtctacaagt ttactattca     5100

gcgacctcct atattccgcg tgccagccga tcaattacca atccaaccag ctatcacacg     5160

gaatacaaga actcgcctac gctcttcttt cgggctgctt ataagcctcc tgtaattttt     5220

ttatattcct cgttaagtcc tcagacttgg caaggagaat gtagatttcc acagtatata     5280

tgttttcaca aaaggaagga gagaaacaaa agaaaatggc actgactaaa cttcagctag     5340

tggtatagga aagtaattct gcttaacaga gattgcagtg atctctatgt atgtcctgaa     5400

gaattatgtt gtactttttt cccccatttt taaatcaaac agtgctttac agaggtcaga     5460

atggtttctt tactgtttgt caattctatt atttcaatac agaacaatag cttctataac     5520

tgaaatatat ttgctattgt atattatgat tgtccctcga accatgaaca ctcctccagc     5580

tgaatttcac aattcctctg tcatctgcca ggccattaag ttattcatgg aagatctttg     5640

aggaacactg caagttcata tcataaacac atttgaaatt gagtattgtt ttgcattgta     5700

tggagctatg ttttgctgta tcctcagaat aaaagtttgt tataaagcat tcacacccat     5760

aaaaagatag atttaaatat tccaactata ggaaagaaag tgtgtctgct cttcactcta     5820

gtctcagttg gctccttcac atgcacgctt ctttatttct cctattttgt caagaaaata     5880

ataggtcaag tcttgttctc atttatgtcc tgtctagcgt ggctcagatg cacattgtac     5940

atacaagaag gatcaaatga aacagacttc tggtctgtta ctacaaccat agtaataagc     6000

acactaacta ataattgcta attatgtttt ccatctccaa ggttcccaca tttttctgtt     6060

ttcttaaaga tcccattatc tggttgtaac tgaagctcaa tggaacatga gcaatatttc     6120

ccagtcttct ctcccatcca acagtcctga tggattagca gaacaggcag aaaacacatt     6180

gttacccaga attaaaaact aatatttgct ctccattcaa tccaaaatgg acctattgaa     6240

actaaaatct aacccaatcc cattaaatga tttctatggt gtcaaaggtc aaacttctga     6300

agggaacctg tgggtgggtc acaattcaga ctatatattc cccagggctc agccagtgtc     6360

tgtacataca gctagaaagc tgtattgcct ttagcagtca agctcgaaag gtaagcaact     6420

ctctggaatt accttctctc tatattagct cttacttgca cctaaacttt aaaaaattaa     6480

caattattgt gctatgtgtt gtatctttaa gggtgaagta cctgcgtgat accccctata     6540

aaaacttctc acctgtgtat gcattctgca ctattttatt atgtgtaaaa gctttgtgtt     6600

tgttttcagg aggcttattc tttgtgctta aaatatgttt ttaatttcag aacatcttat     6660

cctgtcgttc actatctgat atgctttgca gtttgcttga ttaacttcta gccctacaga     6720

gtgcacagag agcaaaatca tggtgttcag tgaattctgg ggagttattt taatgtgaaa     6780

attctctaga agtttaattc ctgcaaagtg cagctgctga tcactacaca agataaaaat     6840

gtggggggtg cataaacgta tattcttaca ataatagata catgtgaact tatatacaga     6900

aaagaaaatg agaaaaatgt gtgtgtgtat actcacacac gtggtcagta aaaacttttg     6960

aggggtttaa tacagaaaat ccaatcctga ggccccagca ctcagtacgc atataaaggg     7020

ctgggctctg aaggacttct gactttcaca gattatataa atctcaggaa agcaactaga     7080

ttcatgctgg ctccaaaagc tgtgctttat ataagcacac tggctataca atagttgtac     7140

agttcagctc tttataatag aaacagacag aacaagtata aatcttctat tggtctatgt     7200

catgaacaag aattcattca gtggctctgt tttatagtaa acattgctat tttatcatgt     7260

ctgcatttct cttctgtctg aatgtcacca ctaaaattta actccacaga aagtttatac     7320

tacagtacac atgcatatct ttgagcaaag caaaccatac ctgaaagtgc aatagagcag     7380

aatatgaatt acatgcgtgt ctttctccta gactacatga ccccatataa attacattcc     7440

ttatctattc tgccatcacc aaaacaaagg taaaaatact tttgaagatc tactcatagc     7500

aagtagtgtg caacaaacag atatttctct acatttattt ttagggaata aaaataagaa     7560

ataaaatagt cagcaagcct ctgctttctc atatatctgt ccaaacctaa agtttactga     7620

aatttgctct ttgaatttcc agttttgcaa gcctatcaga ttgtgtttta atcagaggta     7680

ctgaaaagta tcaatgaatt ctagctttca ctgaacaaaa atatgtagag gcaactggct     7740

tctgggacag tttgctaccc aaaagacaac tgaatgcaaa tacataaata gatttatgaa     7800

tatggttttg aacatgcaca tgagaggtgg atatagcaac agacacatta ccacagaatt     7860

actttaaaac tacttgttaa catttaattg cctaaaaact gctcgtaatt tactgttgta     7920

gcctaccata gagtaccctg catggtacta tgtacagcat tccatcctta cattttcact     7980

gttctgctgt ttgctctaga caactcagag ttcaccatgg aggcggtggc ggtggccgcg     8040

gcggtggggg tccttctcct ggccggggcc gggggcgcgg caggcgacga ggcccgggag     8100

gcggcggccg tgcgggcgct cgtggcccgg ctgctggggc caggccccgc ggccgacttc     8160

tccgtgtcgg tggagcgcgc tctggctgcc aagccgggct tggacaccta cagcctgggc     8220

ggcggcggcg cggcgcgcgt gcgggtgcgc ggctccacgg gcgtggcagc cgccgcgggg     8280

ctgcaccgct acctgcgcga cttctgtggc tgccacgtgg cctggtccgg ctctcagctg     8340

cgcctgccgc ggccactgcc agccgtgccg ggggagctga ccgaggccac gcccaacagg     8400

taccgctatt accagaatgt gtgcacgcaa agctactctt tcgtgtggtg ggactgggcc     8460

cggtgggagc gagagataga ctggatggcg ctgaatggca tcaacctggc actggcatgg     8520

agcggccagg aggccatctg gcagcgggtg tacctggcct tgggcctgac ccaggcagag     8580

atcaatgagt tctttactgg tcctgccttc ttggcatggg ggcgaatggg caacctgcac     8640

acctgggatg gccccctgcc cccctcctgg cacatcaagc agctttatct gcagcaccgg     8700

gtcctggacc agatgcgctc cttcggcatg accccagtgc tgcctgcatt cgcggggcat     8760

gttcccgagg ctgtcaccag ggtgttccct caggtcaatg tcacgaagat gggcagttgg     8820

ggccacttta actgttccta ctcctgctcc ttccttctgg ctccggaaga ccccatattc     8880

cccatcatcg ggagcctctt cttgcgagag ctgatcaaag agtttggcac agaccacatc     8940

tatggggccg acactttcaa tgagatgcag ccaccttcct cagagccctc ctatcttgcc     9000

gcagccacca ctgccgtcta tgaggccatg actgcagtgg atactgaggc tgtgtggctg     9060

ctccaaggct ggctcttcca gcaccagccg cagttctggg ggcccgccca gatcagggct     9120

gtgctgggag ctgtgccccg tggccgcctc ctggttctgg acctgtttgc tgagagccag     9180

cctgtgtata cccgcactgc ctccttccaa ggccagccct tcatctggtg catgctgcac     9240

aactttgggg gaaatcatgg tctttttgga gccttggagg ccgtgaacgg aggcccagaa     9300

gctgcccgcc tcttccccaa ctccacaatg gtaggcacgg gcatggcccc cgagggcatc     9360

agccagaacg aagtggtcta ttccctcatg gctgagctgg gctggcgaaa ggacccagtg     9420

ccagatttgg cagcctgggt gaccagcttt gccgcccggc ggtatggggt ctcccacccg     9480

gacgcagggg cagcgtggag gctactgctc cggagtgtgt acaactgctc cggggaggca     9540

tgcaggggcc acaatcgtag cccgctggtc aggcggccgt ccctacagat gaataccagc     9600

atctggtaca accgatctga tgtgtttgag gcctggcggc tgctgctcac atctgctccc     9660

tccctggcca ccagccccgc cttccgctac gacctgctgg acctcactcg gcaggcagtg     9720

caggagctgg tcagcttgta ttatgaggag gcaagaagcg cctatctgag caaggagctg     9780

gcctccttgt tgagggctgg aggcgtcctg gcctatgagc tgctgccggc actggacgag     9840

gtgctggcta gtgacagccg cttcttgctg ggcagctggc tagagcaggc ccgagcagcg     9900

gcagtcagtg aggccgaggc cgatttctac gagcagaaca gccgctacca gctgaccttg     9960

tgggggccag aaggcaacat cctggactat gccaacaagc agctggcggg gttggtggcc    10020

aactactaca cccctcgctg gcggcttttc ctggaggcgc tggttgacag tgtggcccag    10080

ggcatccctt tccaacagca ccagtttgac aaaaatgtct tccaactgga gcaggccttc    10140

gttctcagca agcagaggta ccccagccag ccgcgaggag acactgtgga cctggccaag    10200

aagatcttcc tcaaatatta cccccgctgg gtggccggct cttggtgatt cgaagc        10256


<210>  2
<211>  2234
<212>  DNA
<213>  Human

<400>  5
atggaggcgg tggcggtggc cgcggcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgaggcccg ggaggcggcg gccgtgcggg cgctcgtggc ccggctgctg      120

gggccaggcc ccgcggccga cttctccgtg tcggtggagc gcgctctggc tgccaagccg      180

ggcttggaca cctacagcct gggcggcggc ggcgcggcgc gcgtgcgggt gcgcggctcc      240

acgggcgtgg cggccgccgc ggggctgcac cgctacctgc gcgacttctg tggctgccac      300

gtggcctggt ccggctctca gctgcgcctg ccgcggccac tgccagccgt gccgggggag      360

ctgaccgagg ccacgcccaa caggtaccgc tattaccaga atgtgtgcac gcaaagctac      420

tctttcgtgt ggtgggactg ggcccgctgg gagcgagaga tagactggat ggcgctgaat      480

ggcatcaacc tggcactggc ctggagcggc caggaggcca tctggcagcg ggtgtacctg      540

gccttgggcc tgacccaggc agagatcaat gagttcttta ctggtcctgc cttcctggcc      600

tgggggcgaa tgggcaacct gcacacctgg gatggccccc tgcccccctc ctggcacatc      660

aagcagcttt acctgcagca ccgggtcctg gaccagatgc gctccttcgg catgacccca      720

gtgctgcctg cattcgcggg gcatgttccc gaggctgtca ccagggtgtt ccctcaggtc      780

aatgtcacga agatgggcag ttggggccac tttaactgtt cctactcctg ctccttcctt      840

ctggctccgg aagaccccat attccccatc atcgggagcc tcttcctgcg agagctgatc      900

aaagagtttg gcacagacca catctatggg gccgacactt tcaatgagat gcagccacct      960

tcctcagagc cctcctacct tgccgcagcc accactgccg tctatgaggc catgactgca     1020

gtggatactg aggctgtgtg gctgctccaa ggctggctct tccagcacca gccgcagttc     1080

tgggggcccg cccagatcag ggctgtgctg ggagctgtgc cccgtggccg cctcctggtt     1140

ctggacctgt ttgctgagag ccagcctgtg tatacccgca ctgcctcctt ccagggccag     1200

cccttcatct ggtgcatgct gcacaacttt gggggaaacc atggtctttt tggagcccta     1260

gaggctgtga acggaggccc agaagctgcc cgcctcttcc ccaactccac catggtaggc     1320

acgggcatgg cccccgaggg catcagccag aacgaagtgg tctattccct catggctgag     1380

ctgggctggc gaaaggaccc agtgccagat ttggcagcct gggtgaccag ctttgccgcc     1440

cggcggtatg gggtctccca cccggacgca ggggcagcgt ggaggctact gctccggagt     1500

gtgtacaact gctccgggga ggcctgcagg ggccacaatc gtagcccgct ggtcaggcgg     1560

ccgtccctac agatgaatac cagcatctgg tacaaccgat ctgatgtgtt tgaggcctgg     1620

cggctgctgc tcacatctgc tccctccctg gccaccagcc ccgccttccg ctacgacctg     1680

ctggacctca ctcggcaggc agtgcaggag ctggtcagct tgtactatga ggaggcaaga     1740

agcgcctacc tgagcaagga gctggcctcc ctgttgaggg ctggaggcgt cctggcctat     1800

gagctgctgc cggcactgga cgaggtgctg gctagtgaca gccgcttctt gctgggcagc     1860

tggctagagc aggcccgagc agcggcagtc agtgaggccg aggccgattt ctacgagcag     1920

aacagccgct accagctgac cttgtggggg ccagaaggca acatcctgga ctatgccaac     1980

aagcagctgg cggggttggt ggccaactac tacacccctc gctggcggct tttcctggag     2040

gcgctggttg acagtgtggc ccagggcatc cctttccaac agcaccagtt tgacaaaaat     2100

gtcttccaac tggagcaggc cttcgttctc agcaagcaga ggtaccccag ccagccgcga     2160

ggagacactg tggacctggc caagaagatc ttcctcaaat attacccccg ctgggtggcc     2220

ggctcttggt gata                                                       2234


