                         SEQUENCE LISTING

<110>  Advaxis, Inc.
 
<120>  PERSONALIZED DELIVERY VECTOR-BASED IMMUNOTHERAPY AND USES THEREOF

<130>  062384/490970

<150>  US 62/287,871
<151>  2016-01-27

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  1

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  2
<211>  32
<212>  PRT
<213>  Listeria monocytogenes

<400>  2

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys 
            20                  25                  30          


<210>  3
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  3

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  4
<211>  441
<212>  PRT
<213>  Listeria monocytogenes

<400>  4

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  5
<211>  416
<212>  PRT
<213>  Listeria monocytogenes

<400>  5

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  6
<211>  14
<212>  PRT
<213>  Listeria monocytogenes

<400>  6

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  7
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  7

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  8
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  8

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  9
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  9

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  10
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  10

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  11
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  11

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  12
<211>  633
<212>  PRT
<213>  Listeria monocytogenes

<400>  12

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys Val Lys Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Ala Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly Asn Val Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Val Asp Arg Pro Thr Leu Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Ala Asn Lys Arg Lys Val Ala Lys Glu Ser Val Val 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln Lys Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Thr Pro Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Met Arg Glu Thr Ala Pro Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Ser Gly Asp Leu Ala Ser Leu Arg Ser Ala Ile Asn Arg His Ser 
        355                 360                 365             


Glu Asn Phe Ser Asp Phe Pro Leu Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser 
385                 390                 395                 400 


Gly Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile 
                405                 410                 415     


Asp Arg Leu Ala Asp Leu Arg Asp Arg Gly Thr Gly Lys His Ser Arg 
            420                 425                 430         


Asn Ala Gly Phe Leu Pro Leu Asn Pro Phe Ile Ser Ser Pro Val Pro 
        435                 440                 445             


Ser Leu Thr Pro Lys Val Pro Lys Ile Ser Ala Pro Ala Leu Ile Ser 
    450                 455                 460                 


Asp Ile Thr Lys Lys Ala Pro Phe Lys Asn Pro Ser Gln Pro Leu Asn 
465                 470                 475                 480 


Val Phe Asn Lys Lys Thr Thr Thr Lys Thr Val Thr Lys Lys Pro Thr 
                485                 490                 495     


Pro Val Lys Thr Ala Pro Lys Leu Ala Glu Leu Pro Ala Thr Lys Pro 
            500                 505                 510         


Gln Glu Thr Val Leu Arg Glu Asn Lys Thr Pro Phe Ile Glu Lys Gln 
        515                 520                 525             


Ala Glu Thr Asn Lys Gln Ser Ile Asn Met Pro Ser Leu Pro Val Ile 
    530                 535                 540                 


Gln Lys Glu Ala Thr Glu Ser Asp Lys Glu Glu Met Lys Pro Gln Thr 
545                 550                 555                 560 


Glu Glu Lys Met Val Glu Glu Ser Glu Ser Ala Asn Asn Ala Asn Gly 
                565                 570                 575     


Lys Asn Arg Ser Ala Gly Ile Glu Glu Gly Lys Leu Ile Ala Lys Ser 
            580                 585                 590         


Ala Glu Asp Glu Lys Ala Lys Glu Glu Pro Gly Asn His Thr Thr Leu 
        595                 600                 605             


Ile Leu Ala Met Leu Ala Ile Gly Val Phe Ser Leu Gly Ala Phe Ile 
    610                 615                 620                 


Lys Ile Ile Gln Leu Arg Lys Asn Asn 
625                 630             


<210>  13
<211>  390
<212>  PRT
<213>  Listeria monocytogenes

<400>  13

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys Val Arg Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Glu Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Ile Asn Asn Asn Asn Ser Glu Gln Thr Glu Asn Ala Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Ala Asp Arg Pro Ala Ile Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Pro Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Val Asn Lys Lys Lys Val Ala Lys Glu Ser Val Ala 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Ser Pro Gln Pro Leu Lys Ala Asn Gln Gln Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Ile Arg Glu Thr Ala Ser Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Arg Gly Asp Leu Ala Ser Leu Arg Asn Ala Ile Asn Arg His Ser 
        355                 360                 365             


Gln Asn Phe Ser Asp Phe Pro Pro Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  14
<211>  100
<212>  PRT
<213>  Listeria monocytogenes

<400>  14

Met Gly Leu Asn Arg Phe Met Arg Ala Met Met Val Val Phe Ile Thr 
1               5                   10                  15      


Ala Asn Cys Ile Thr Ile Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp 
            20                  25                  30          


Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr 
        35                  40                  45              


Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala 
    50                  55                  60                  


Arg Glu Val Ser Ser Arg Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys 
65                  70                  75                  80  


Val Arg Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Glu Lys 
                85                  90                  95      


Ala Glu Lys Gly 
            100 


<210>  15
<211>  639
<212>  PRT
<213>  Listeria monocytogenes

<400>  15

Met Gly Leu Asn Arg Phe Met Arg Ala Met Met Val Val Phe Ile Thr 
1               5                   10                  15      


Ala Asn Cys Ile Thr Ile Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp 
            20                  25                  30          


Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr 
        35                  40                  45              


Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala 
    50                  55                  60                  


Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys 
65                  70                  75                  80  


Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Ala Lys 
                85                  90                  95      


Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly 
            100                 105                 110         


Asn Val Ala Ile Asn Glu Glu Ala Ser Gly Val Asp Arg Pro Thr Leu 
        115                 120                 125             


Gln Val Glu Arg Arg His Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu 
    130                 135                 140                 


Ile Lys Lys Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu 
145                 150                 155                 160 


Ser Leu Thr Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys Arg Lys Val 
                165                 170                 175     


Ala Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser 
            180                 185                 190         


Met Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln 
        195                 200                 205             


Lys Pro Phe Phe Pro Lys Val Phe Lys Lys Ile Lys Asp Ala Gly Lys 
    210                 215                 220                 


Trp Val Arg Asp Lys Ile Asp Glu Asn Pro Glu Val Lys Lys Ala Ile 
225                 230                 235                 240 


Val Asp Lys Ser Ala Gly Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys 
                245                 250                 255     


Ser Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu 
            260                 265                 270         


Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn 
        275                 280                 285             


Ala Pro Thr Pro Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro 
    290                 295                 300                 


Thr Asp Glu Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro Met Leu Leu 
305                 310                 315                 320 


Gly Phe Asn Ala Pro Ala Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro 
                325                 330                 335     


Pro Pro Pro Thr Glu Asp Glu Leu Glu Ile Met Arg Glu Thr Ala Pro 
            340                 345                 350         


Ser Leu Asp Ser Ser Phe Thr Ser Gly Asp Leu Ala Ser Leu Arg Ser 
        355                 360                 365             


Ala Ile Asn Arg His Ser Glu Asn Phe Ser Asp Phe Pro Leu Ile Pro 
    370                 375                 380                 


Thr Glu Glu Glu Leu Asn Gly Arg Gly Gly Arg Pro Thr Ser Glu Glu 
385                 390                 395                 400 


Phe Ser Ser Leu Asn Ser Gly Asp Phe Thr Asp Asp Glu Asn Ser Glu 
                405                 410                 415     


Thr Thr Glu Glu Glu Ile Asp Arg Leu Ala Asp Leu Arg Asp Arg Gly 
            420                 425                 430         


Thr Gly Lys His Ser Arg Asn Ala Gly Phe Leu Pro Leu Asn Pro Phe 
        435                 440                 445             


Ile Ser Ser Pro Val Pro Ser Leu Thr Pro Lys Val Pro Lys Ile Ser 
    450                 455                 460                 


Ala Pro Ala Leu Ile Ser Asp Ile Thr Lys Lys Ala Pro Phe Lys Asn 
465                 470                 475                 480 


Pro Ser Gln Pro Leu Asn Val Phe Asn Lys Lys Thr Thr Thr Lys Thr 
                485                 490                 495     


Val Thr Lys Lys Pro Thr Pro Val Lys Thr Ala Pro Lys Leu Ala Glu 
            500                 505                 510         


Leu Pro Ala Thr Lys Pro Gln Glu Thr Val Leu Arg Glu Asn Lys Thr 
        515                 520                 525             


Pro Phe Ile Glu Lys Gln Ala Glu Thr Asn Lys Gln Ser Ile Asn Met 
    530                 535                 540                 


Pro Ser Leu Pro Val Ile Gln Lys Glu Ala Thr Glu Ser Asp Lys Glu 
545                 550                 555                 560 


Glu Met Lys Pro Gln Thr Glu Glu Lys Met Val Glu Glu Ser Glu Ser 
                565                 570                 575     


Ala Asn Asn Ala Asn Gly Lys Asn Arg Ser Ala Gly Ile Glu Glu Gly 
            580                 585                 590         


Lys Leu Ile Ala Lys Ser Ala Glu Asp Glu Lys Ala Lys Glu Glu Pro 
        595                 600                 605             


Gly Asn His Thr Thr Leu Ile Leu Ala Met Leu Ala Ile Gly Val Phe 
    610                 615                 620                 


Ser Leu Gly Ala Phe Ile Lys Ile Ile Gln Leu Arg Lys Asn Asn 
625                 630                 635                 


<210>  16
<211>  93
<212>  PRT
<213>  Listeria monocytogenes

<400>  16

Ala Thr Asp Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu 
1               5                   10                  15      


Glu Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr 
            20                  25                  30          


Glu Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys 
        35                  40                  45              


Ser Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu 
    50                  55                  60                  


Lys Ala Lys Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu 
65                  70                  75                  80  


Gln Thr Gly Asn Val Ala Ile Asn Glu Glu Ala Ser Gly 
                85                  90              


<210>  17
<211>  200
<212>  PRT
<213>  Listeria monocytogenes

<400>  17

Ala Thr Asp Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu 
1               5                   10                  15      


Glu Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr 
            20                  25                  30          


Glu Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys 
        35                  40                  45              


Ser Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu 
    50                  55                  60                  


Lys Ala Lys Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu 
65                  70                  75                  80  


Gln Thr Gly Asn Val Ala Ile Asn Glu Glu Ala Ser Gly Val Asp Arg 
                85                  90                  95      


Pro Thr Leu Gln Val Glu Arg Arg His Pro Gly Leu Ser Ser Asp Ser 
            100                 105                 110         


Ala Ala Glu Ile Lys Lys Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser 
        115                 120                 125             


Glu Leu Glu Ser Leu Thr Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys 
    130                 135                 140                 


Arg Lys Val Ala Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu 
145                 150                 155                 160 


Asp Ser Ser Met Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
                165                 170                 175     


Ala Asn Gln Lys Pro Phe Phe Pro Lys Val Phe Lys Lys Ile Lys Asp 
            180                 185                 190         


Ala Gly Lys Trp Val Arg Asp Lys 
        195                 200 


<210>  18
<211>  226
<212>  PRT
<213>  Listeria monocytogenes

<400>  18

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Ser Arg Ala Thr Asp Ser Glu Asp 
            20                  25                  30          


Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln 
        35                  40                  45              


Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val 
    50                  55                  60                  


Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys Val Lys Asn 
65                  70                  75                  80  


Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Ala Lys Ala Glu Lys 
                85                  90                  95      


Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly Asn Val Ala 
            100                 105                 110         


Ile Asn Glu Glu Ala Ser Gly Val Asp Arg Pro Thr Leu Gln Val Glu 
        115                 120                 125             


Arg Arg His Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu Ile Lys Lys 
    130                 135                 140                 


Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr 
145                 150                 155                 160 


Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys Arg Lys Val Ala Lys Glu 
                165                 170                 175     


Ser Val Val Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser 
            180                 185                 190         


Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln Lys Pro Phe 
        195                 200                 205             


Phe Pro Lys Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg 
    210                 215                 220                 


Asp Lys 
225     


<210>  19
<211>  678
<212>  DNA
<213>  Listeria monocytogenes

<400>  19
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag catctagagc gacagatagc gaagattcca gtctaaacac agatgaatgg      120

gaagaagaaa aaacagaaga gcagccaagc gaggtaaata cgggaccaag atacgaaact      180

gcacgtgaag taagttcacg tgatattgag gaactagaaa aatcgaataa agtgaaaaat      240

acgaacaaag cagacctaat agcaatgttg aaagcaaaag cagagaaagg tccgaataac      300

aataataaca acggtgagca aacaggaaat gtggctataa atgaagaggc ttcaggagtc      360

gaccgaccaa ctctgcaagt ggagcgtcgt catccaggtc tgtcatcgga tagcgcagcg      420

gaaattaaaa aaagaagaaa agccatagcg tcgtcggata gtgagcttga aagccttact      480

tatccagata aaccaacaaa agcaaataag agaaaagtgg cgaaagagtc agttgtggat      540

gcttctgaaa gtgacttaga ttctagcatg cagtcagcag acgagtctac accacaacct      600

ttaaaagcaa atcaaaaacc atttttccct aaagtattta aaaaaataaa agatgcgggg      660

aaatgggtac gtgataaa                                                    678


<210>  20
<211>  303
<212>  PRT
<213>  Listeria monocytogenes

<400>  20

Ala Thr Asp Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu 
1               5                   10                  15      


Glu Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr 
            20                  25                  30          


Glu Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys 
        35                  40                  45              


Ser Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu 
    50                  55                  60                  


Lys Ala Lys Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu 
65                  70                  75                  80  


Gln Thr Gly Asn Val Ala Ile Asn Glu Glu Ala Ser Gly Val Asp Arg 
                85                  90                  95      


Pro Thr Leu Gln Val Glu Arg Arg His Pro Gly Leu Ser Ser Asp Ser 
            100                 105                 110         


Ala Ala Glu Ile Lys Lys Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser 
        115                 120                 125             


Glu Leu Glu Ser Leu Thr Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys 
    130                 135                 140                 


Arg Lys Val Ala Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu 
145                 150                 155                 160 


Asp Ser Ser Met Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
                165                 170                 175     


Ala Asn Gln Lys Pro Phe Phe Pro Lys Val Phe Lys Lys Ile Lys Asp 
            180                 185                 190         


Ala Gly Lys Trp Val Arg Asp Lys Ile Asp Glu Asn Pro Glu Val Lys 
        195                 200                 205             


Lys Ala Ile Val Asp Lys Ser Ala Gly Leu Ile Asp Gln Leu Leu Thr 
    210                 215                 220                 


Lys Lys Lys Ser Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro 
225                 230                 235                 240 


Thr Asp Glu Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro Met Leu Leu 
                245                 250                 255     


Gly Phe Asn Ala Pro Thr Pro Ser Glu Pro Ser Ser Phe Glu Phe Pro 
            260                 265                 270         


Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro 
        275                 280                 285             


Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu Pro Ser Ser 
    290                 295                 300             


<210>  21
<211>  370
<212>  PRT
<213>  Listeria monocytogenes

<400>  21

Ala Thr Asp Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu 
1               5                   10                  15      


Glu Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr 
            20                  25                  30          


Glu Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys 
        35                  40                  45              


Ser Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu 
    50                  55                  60                  


Lys Ala Lys Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu 
65                  70                  75                  80  


Gln Thr Gly Asn Val Ala Ile Asn Glu Glu Ala Ser Gly Val Asp Arg 
                85                  90                  95      


Pro Thr Leu Gln Val Glu Arg Arg His Pro Gly Leu Ser Ser Asp Ser 
            100                 105                 110         


Ala Ala Glu Ile Lys Lys Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser 
        115                 120                 125             


Glu Leu Glu Ser Leu Thr Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys 
    130                 135                 140                 


Arg Lys Val Ala Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu 
145                 150                 155                 160 


Asp Ser Ser Met Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
                165                 170                 175     


Ala Asn Gln Lys Pro Phe Phe Pro Lys Val Phe Lys Lys Ile Lys Asp 
            180                 185                 190         


Ala Gly Lys Trp Val Arg Asp Lys Ile Asp Glu Asn Pro Glu Val Lys 
        195                 200                 205             


Lys Ala Ile Val Asp Lys Ser Ala Gly Leu Ile Asp Gln Leu Leu Thr 
    210                 215                 220                 


Lys Lys Lys Ser Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro 
225                 230                 235                 240 


Thr Asp Glu Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro Met Leu Leu 
                245                 250                 255     


Gly Phe Asn Ala Pro Thr Pro Ser Glu Pro Ser Ser Phe Glu Phe Pro 
            260                 265                 270         


Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu Pro Glu Thr Pro 
        275                 280                 285             


Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu Pro Ser Ser Phe 
    290                 295                 300                 


Glu Phe Pro Pro Pro Pro Thr Glu Asp Glu Leu Glu Ile Met Arg Glu 
305                 310                 315                 320 


Thr Ala Pro Ser Leu Asp Ser Ser Phe Thr Ser Gly Asp Leu Ala Ser 
                325                 330                 335     


Leu Arg Ser Ala Ile Asn Arg His Ser Glu Asn Phe Ser Asp Phe Pro 
            340                 345                 350         


Leu Ile Pro Thr Glu Glu Glu Leu Asn Gly Arg Gly Gly Arg Pro Thr 
        355                 360                 365             


Ser Glu 
    370 


<210>  22
<211>  1170
<212>  DNA
<213>  Listeria monocytogenes

<400>  22
atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattct agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcaaccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattaa agaactagaa aaatcgaata aagtgagaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagaaaaa gcagaaaaag gtccaaatat caataataac      300

aacagtgaac aaactgagaa tgcggctata aatgaagagg cttcaggagc cgaccgacca      360

gctatacaag tggagcgtcg tcatccagga ttgccatcgg atagcgcagc ggaaattaaa      420

aaaagaagga aagccatagc atcatcggat agtgagcttg aaagccttac ttatccggat      480

aaaccaacaa aagtaaataa gaaaaaagtg gcgaaagagt cagttgcgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gatgagtctt caccacaacc tttaaaagca      600

aaccaacaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccaat gcttcttggt      840

tttaatgctc ctgctacatc agaaccgagc tcattcgaat ttccaccacc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcgtt cgaatttcca ccgcctccaa cagaagatga actagaaatc     1020

atccgggaaa cagcatcctc gctagattct agttttacaa gaggggattt agctagtttg     1080

agaaatgcta ttaatcgcca tagtcaaaat ttctctgatt tcccaccaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  23
<211>  6523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  23
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagattgt gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg     2460

cctctcgtgg cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag     2520

ctgcccactg catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc     2580

ctgaagacac aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata     2640

tgagcctcct gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc     2700

tgctccgcct gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca     2760

cccaggagcc agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag     2820

aggagttctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     2880

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     2940

cagggggcaa aagcacctgc tcgggtgatt ctgggggccc acttgtctgt tatggtgtgc     3000

ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt     3060

acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctaac     3120

ccgggccact aactcaacgc tagtagtgga tttaatccca aatgagccaa cagaaccaga     3180

accagaaaca gaacaagtaa cattggagtt agaaatggaa gaagaaaaaa gcaatgattt     3240

cgtgtgaata atgcacgaaa tcattgctta tttttttaaa aagcgatata ctagatataa     3300

cgaaacaacg aactgaataa agaatacaaa aaaagagcca cgaccagtta aagcctgaga     3360

aactttaact gcgagcctta attgattacc accaatcaat taaagaagtc gagacccaaa     3420

atttggtaaa gtatttaatt actttattaa tcagatactt aaatatctgt aaacccatta     3480

tatcgggttt ttgaggggat ttcaagtctt taagaagata ccaggcaatc aattaagaaa     3540

aacttagttg attgcctttt ttgttgtgat tcaactttga tcgtagcttc taactaatta     3600

attttcgtaa gaaaggagaa cagctgaatg aatatccctt ttgttgtaga aactgtgctt     3660

catgacggct tgttaaagta caaatttaaa aatagtaaaa ttcgctcaat cactaccaag     3720

ccaggtaaaa gtaaaggggc tatttttgcg tatcgctcaa aaaaaagcat gattggcgga     3780

cgtggcgttg ttctgacttc cgaagaagcg attcacgaaa atcaagatac atttacgcat     3840

tggacaccaa acgtttatcg ttatggtacg tatgcagacg aaaaccgttc atacactaaa     3900

ggacattctg aaaacaattt aagacaaatc aataccttct ttattgattt tgatattcac     3960

acggaaaaag aaactatttc agcaagcgat attttaacaa cagctattga tttaggtttt     4020

atgcctacgt taattatcaa atctgataaa ggttatcaag catattttgt tttagaaacg     4080

ccagtctatg tgacttcaaa atcagaattt aaatctgtca aagcagccaa aataatctcg     4140

caaaatatcc gagaatattt tggaaagtct ttgccagttg atctaacgtg caatcatttt     4200

gggattgctc gtataccaag aacggacaat gtagaatttt ttgatcccaa ttaccgttat     4260

tctttcaaag aatggcaaga ttggtctttc aaacaaacag ataataaggg ctttactcgt     4320

tcaagtctaa cggttttaag cggtacagaa ggcaaaaaac aagtagatga accctggttt     4380

aatctcttat tgcacgaaac gaaattttca ggagaaaagg gtttagtagg gcgcaatagc     4440

gttatgttta ccctctcttt agcctacttt agttcaggct attcaatcga aacgtgcgaa     4500

tataatatgt ttgagtttaa taatcgatta gatcaaccct tagaagaaaa agaagtaatc     4560

aaaattgtta gaagtgccta ttcagaaaac tatcaagggg ctaataggga atacattacc     4620

attctttgca aagcttgggt atcaagtgat ttaaccagta aagatttatt tgtccgtcaa     4680

gggtggttta aattcaagaa aaaaagaagc gaacgtcaac gtgttcattt gtcagaatgg     4740

aaagaagatt taatggctta tattagcgaa aaaagcgatg tatacaagcc ttatttagcg     4800

acgaccaaaa aagagattag agaagtgcta ggcattcctg aacggacatt agataaattg     4860

ctgaaggtac tgaaggcgaa tcaggaaatt ttctttaaga ttaaaccagg aagaaatggt     4920

ggcattcaac ttgctagtgt taaatcattg ttgctatcga tcattaaatt aaaaaaagaa     4980

gaacgagaaa gctatataaa ggcgctgaca gcttcgttta atttagaacg tacatttatt     5040

caagaaactc taaacaaatt ggcagaacgc cccaaaacgg acccacaact cgatttgttt     5100

agctacgata caggctgaaa ataaaacccg cactatgcca ttacatttat atctatgata     5160

cgtgtttgtt tttctttgct ggctagctta attgcttata tttacctgca ataaaggatt     5220

tcttacttcc attatactcc cattttccaa aaacatacgg ggaacacggg aacttattgt     5280

acaggccacc tcatagttaa tggtttcgag ccttcctgca atctcatcca tggaaatata     5340

ttcatccccc tgccggccta ttaatgtgac ttttgtgccc ggcggatatt cctgatccag     5400

ctccaccata aattggtcca tgcaaattcg gccggcaatt ttcaggcgtt ttcccttcac     5460

aaggatgtcg gtccctttca attttcggag ccagccgtcc gcatagccta caggcaccgt     5520

cccgatccat gtgtcttttt ccgctgtgta ctcggctccg tagctgacgc tctcgccttt     5580

tctgatcagt ttgacatgtg acagtgtcga atgcagggta aatgccggac gcagctgaaa     5640

cggtatctcg tccgacatgt cagcagacgg gcgaaggcca tacatgccga tgccgaatct     5700

gactgcatta aaaaagcctt ttttcagccg gagtccagcg gcgctgttcg cgcagtggac     5760

cattagattc tttaacggca gcggagcaat cagctcttta aagcgctcaa actgcattaa     5820

gaaatagcct ctttcttttt catccgctgt cgcaaaatgg gtaaataccc ctttgcactt     5880

taaacgaggg ttgcggtcaa gaattgccat cacgttctga acttcttcct ctgtttttac     5940

accaagtctg ttcatccccg tatcgacctt cagatgaaaa tgaagagaac cttttttcgt     6000

gtggcgggct gcctcctgaa gccattcaac agaataacct gttaaggtca cgtcatactc     6060

agcagcgatt gccacatact ccgggggaac cgcgccaagc accaatatag gcgccttcaa     6120

tccctttttg cgcagtgaaa tcgcttcatc caaaatggcc acggccaagc atgaagcacc     6180

tgcgtcaaga gcagcctttg ctgtttctgc atcaccatgc ccgtaggcgt ttgctttcac     6240

aactgccatc aagtggacat gttcaccgat atgttttttc atattgctga cattttcctt     6300

tatcgcggac aagtcaattt ccgcccacgt atctctgtaa aaaggttttg tgctcatgga     6360

aaactcctct cttttttcag aaaatcccag tacgtaatta agtatttgag aattaatttt     6420

atattgatta atactaagtt tacccagttt tcacctaaaa aacaaatgat gagataatag     6480

ctccaaaggc taaagaggac tataccaact atttgttaat taa                       6523


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
cggaattcgg atccgcgcca aatcattggt tgattg                                 36


<210>  25
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
gcgagtcgac gtcggggtta atcgtaatgc aattggc                                37


<210>  26
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
gcgagtcgac ccatacgacg ttaattcttg caatg                                  35


<210>  27
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
gatactgcag ggatccttcc cttctcggta atcagtcac                              39


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
tgggatggcc aagaaattc                                                    19


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
ctaccatgtc ttccgttgct tg                                                22


<210>  30
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
tgatctcgag acccacctgg acatgctc                                          28


<210>  31
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
ctaccaggac acgattttgt ggaagaatat ccaggagttt gctggctgc                   49


<210>  32
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
gcagccagca aactcctgga tattcttcca caaaatcgtg tcctggtag                   49


<210>  33
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
ctgccaccag ctgtgcgccc gagggcagca gaagatccgg aagtacacga                  50


<210>  34
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
tcgtgtactt ccggatcttc tgctgccctc gggcgcacag ctggtggcag                  50


<210>  35
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
gtggcccggg tctagattag tctaagaggc agccatagg                              39


<210>  36
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  36
ccgcctcgag gccgcgagca cccaagtg                                          28


<210>  37
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
cgcgactagt ttaatcctct gctgtcacct c                                      31


<210>  38
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
ccgcctcgag tacctttcta cggacgtg                                          28


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
cgcgactagt ttactctggc cggttggcag                                        30


<210>  40
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
ccgcctcgag cagcagaaga tccggaagta c                                      31


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
cgcgactagt ttaagcccct tcggagggtg                                        30


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


<210>  45
<211>  5851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  45
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgaggagct cctgcagtct agagtcgaca ctagtggatc cagatctccc gggccactaa     2460

ctcaacgcta gtagtggatt taatcccaaa tgagccaaca gaaccagaac cagaaacaga     2520

acaagtaaca ttggagttag aaatggaaga agaaaaaagc aatgatttcg tgtgaataat     2580

gcacgaaatc attgcttatt tttttaaaaa gcgatatact agatataacg aaacaacgaa     2640

ctgaataaag aatacaaaaa aagagccacg accagttaaa gcctgagaaa ctttaactgc     2700

gagccttaat tgattaccac caatcaatta aagaagtcga gacccaaaat ttggtaaagt     2760

atttaattac tttattaatc agatacttaa atatctgtaa acccattata tcgggttttt     2820

gaggggattt caagtcttta agaagatacc aggcaatcaa ttaagaaaaa cttagttgat     2880

tgcctttttt gttgtgattc aactttgatc gtagcttcta actaattaat tttcgtaaga     2940

aaggagaaca gctgaatgaa tatccctttt gttgtagaaa ctgtgcttca tgacggcttg     3000

ttaaagtaca aatttaaaaa tagtaaaatt cgctcaatca ctaccaagcc aggtaaaagt     3060

aaaggggcta tttttgcgta tcgctcaaaa aaaagcatga ttggcggacg tggcgttgtt     3120

ctgacttccg aagaagcgat tcacgaaaat caagatacat ttacgcattg gacaccaaac     3180

gtttatcgtt atggtacgta tgcagacgaa aaccgttcat acactaaagg acattctgaa     3240

aacaatttaa gacaaatcaa taccttcttt attgattttg atattcacac ggaaaaagaa     3300

actatttcag caagcgatat tttaacaaca gctattgatt taggttttat gcctacgtta     3360

attatcaaat ctgataaagg ttatcaagca tattttgttt tagaaacgcc agtctatgtg     3420

acttcaaaat cagaatttaa atctgtcaaa gcagccaaaa taatctcgca aaatatccga     3480

gaatattttg gaaagtcttt gccagttgat ctaacgtgca atcattttgg gattgctcgt     3540

ataccaagaa cggacaatgt agaatttttt gatcccaatt accgttattc tttcaaagaa     3600

tggcaagatt ggtctttcaa acaaacagat aataagggct ttactcgttc aagtctaacg     3660

gttttaagcg gtacagaagg caaaaaacaa gtagatgaac cctggtttaa tctcttattg     3720

cacgaaacga aattttcagg agaaaagggt ttagtagggc gcaatagcgt tatgtttacc     3780

ctctctttag cctactttag ttcaggctat tcaatcgaaa cgtgcgaata taatatgttt     3840

gagtttaata atcgattaga tcaaccctta gaagaaaaag aagtaatcaa aattgttaga     3900

agtgcctatt cagaaaacta tcaaggggct aatagggaat acattaccat tctttgcaaa     3960

gcttgggtat caagtgattt aaccagtaaa gatttatttg tccgtcaagg gtggtttaaa     4020

ttcaagaaaa aaagaagcga acgtcaacgt gttcatttgt cagaatggaa agaagattta     4080

atggcttata ttagcgaaaa aagcgatgta tacaagcctt atttagcgac gaccaaaaaa     4140

gagattagag aagtgctagg cattcctgaa cggacattag ataaattgct gaaggtactg     4200

aaggcgaatc aggaaatttt ctttaagatt aaaccaggaa gaaatggtgg cattcaactt     4260

gctagtgtta aatcattgtt gctatcgatc attaaattaa aaaaagaaga acgagaaagc     4320

tatataaagg cgctgacagc ttcgtttaat ttagaacgta catttattca agaaactcta     4380

aacaaattgg cagaacgccc caaaacggac ccacaactcg atttgtttag ctacgataca     4440

ggctgaaaat aaaacccgca ctatgccatt acatttatat ctatgatacg tgtttgtttt     4500

tctttgctgg ctagcttaat tgcttatatt tacctgcaat aaaggatttc ttacttccat     4560

tatactccca ttttccaaaa acatacgggg aacacgggaa cttattgtac aggccacctc     4620

atagttaatg gtttcgagcc ttcctgcaat ctcatccatg gaaatatatt catccccctg     4680

ccggcctatt aatgtgactt ttgtgcccgg cggatattcc tgatccagct ccaccataaa     4740

ttggtccatg caaattcggc cggcaatttt caggcgtttt cccttcacaa ggatgtcggt     4800

ccctttcaat tttcggagcc agccgtccgc atagcctaca ggcaccgtcc cgatccatgt     4860

gtctttttcc gctgtgtact cggctccgta gctgacgctc tcgccttttc tgatcagttt     4920

gacatgtgac agtgtcgaat gcagggtaaa tgccggacgc agctgaaacg gtatctcgtc     4980

cgacatgtca gcagacgggc gaaggccata catgccgatg ccgaatctga ctgcattaaa     5040

aaagcctttt ttcagccgga gtccagcggc gctgttcgcg cagtggacca ttagattctt     5100

taacggcagc ggagcaatca gctctttaaa gcgctcaaac tgcattaaga aatagcctct     5160

ttctttttca tccgctgtcg caaaatgggt aaatacccct ttgcacttta aacgagggtt     5220

gcggtcaaga attgccatca cgttctgaac ttcttcctct gtttttacac caagtctgtt     5280

catccccgta tcgaccttca gatgaaaatg aagagaacct tttttcgtgt ggcgggctgc     5340

ctcctgaagc cattcaacag aataacctgt taaggtcacg tcatactcag cagcgattgc     5400

cacatactcc gggggaaccg cgccaagcac caatataggc gccttcaatc cctttttgcg     5460

cagtgaaatc gcttcatcca aaatggccac ggccaagcat gaagcacctg cgtcaagagc     5520

agcctttgct gtttctgcat caccatgccc gtaggcgttt gctttcacaa ctgccatcaa     5580

gtggacatgt tcaccgatat gttttttcat attgctgaca ttttccttta tcacggacaa     5640

gtcaatttcc gcccacgtat ctctgtaaaa aggttttgtg ctcatggaaa actcctctct     5700

tttttcagaa aatcccagta cgtaattaag tatttgagaa ttaattttat attgattaat     5760

actaagttta cccagttttc acctaaaaaa caaatgatga gataatagct ccaaaggcta     5820

aagaggacta taccaactat ttgttaatta a                                    5851


<210>  46
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46
ggtggtggag ga                                                           12


<210>  47
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47
ggtggaggtg ga                                                           12


<210>  48
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48
ggtggaggag gt                                                           12


<210>  49
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  49
ggaggtggtg ga                                                           12


<210>  50
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50
ggaggaggtg gt                                                           12


<210>  51
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  51
ggaggtggag gt                                                           12


<210>  52
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  52
ggaggaggag gt                                                           12


<210>  53
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  53
ggaggaggtg ga                                                           12


<210>  54
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  54
ggaggtggag ga                                                           12


<210>  55
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55
ggtggaggag ga                                                           12


<210>  56
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56
ggaggaggag ga                                                           12


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tagged peptide

<400>  57

Ala Arg Ser Ile Ile Asn Phe Glu Lys Leu Ser His His His His His 
1               5                   10                  15      


His 
    


<210>  58
<211>  7075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  58
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagaccca cctggacatg ctccgccacc tctaccaggg ctgccaggtg gtgcagggaa     2460

acctggaact cacctacctg cccaccaatg ccagcctgtc cttcctgcag gatatccagg     2520

aggtgcaggg ctacgtgctc atcgctcaca accaagtgag gcaggtccca ctgcagaggc     2580

tgcggattgt gcgaggcacc cagctctttg aggacaacta tgccctggcc gtgctagaca     2640

atggagaccc gctgaacaat accacccctg tcacaggggc ctccccagga ggcctgcggg     2700

agctgcagct tcgaagcctc acagagatct tgaaaggagg ggtcttgatc cagcggaacc     2760

cccagctctg ctaccaggac acgattttgt ggaagaatat ccaggagttt gctggctgca     2820

agaagatctt tgggagcctg gcatttctgc cggagagctt tgatggggac ccagcctcca     2880

acactgcccc gctccagcca gagcagctcc aagtgtttga gactctggaa gagatcacag     2940

gttacctata catctcagca tggccggaca gcctgcctga cctcagcgtc ttccagaacc     3000

tgcaagtaat ccggggacga attctgcaca atggcgccta ctcgctgacc ctgcaagggc     3060

tgggcatcag ctggctgggg ctgcgctcac tgagggaact gggcagtgga ctggccctca     3120

tccaccataa cacccacctc tgcttcgtgc acacggtgcc ctgggaccag ctctttcgga     3180

acccgcacca agctctgctc cacactgcca accggccaga ggacgagtgt gtgggcgagg     3240

gcctggcctg ccaccagctg tgcgcccgag ggcagcagaa gatccggaag tacacgatgc     3300

ggagactgct gcaggaaacg gagctggtgg agccgctgac acctagcgga gcgatgccca     3360

accaggcgca gatgcggatc ctgaaagaga cggagctgag gaaggtgaag gtgcttggat     3420

ctggcgcttt tggcacagtc tacaagggca tctggatccc tgatggggag aatgtgaaaa     3480

ttccagtggc catcaaagtg ttgagggaaa acacatcccc caaagccaac aaagaaatct     3540

tagacgaagc atacgtgatg gctggtgtgg gctccccata tgtctcccgc cttctgggca     3600

tctgcctgac atccacggtg cagctggtga cacagcttat gccctatggc tgcctcttag     3660

actaatctag acccgggcca ctaactcaac gctagtagtg gatttaatcc caaatgagcc     3720

aacagaacca gaaccagaaa cagaacaagt aacattggag ttagaaatgg aagaagaaaa     3780

aagcaatgat ttcgtgtgaa taatgcacga aatcattgct tattttttta aaaagcgata     3840

tactagatat aacgaaacaa cgaactgaat aaagaataca aaaaaagagc cacgaccagt     3900

taaagcctga gaaactttaa ctgcgagcct taattgatta ccaccaatca attaaagaag     3960

tcgagaccca aaatttggta aagtatttaa ttactttatt aatcagatac ttaaatatct     4020

gtaaacccat tatatcgggt ttttgagggg atttcaagtc tttaagaaga taccaggcaa     4080

tcaattaaga aaaacttagt tgattgcctt ttttgttgtg attcaacttt gatcgtagct     4140

tctaactaat taattttcgt aagaaaggag aacagctgaa tgaatatccc ttttgttgta     4200

gaaactgtgc ttcatgacgg cttgttaaag tacaaattta aaaatagtaa aattcgctca     4260

atcactacca agccaggtaa aagtaaaggg gctatttttg cgtatcgctc aaaaaaaagc     4320

atgattggcg gacgtggcgt tgttctgact tccgaagaag cgattcacga aaatcaagat     4380

acatttacgc attggacacc aaacgtttat cgttatggta cgtatgcaga cgaaaaccgt     4440

tcatacacta aaggacattc tgaaaacaat ttaagacaaa tcaatacctt ctttattgat     4500

tttgatattc acacggaaaa agaaactatt tcagcaagcg atattttaac aacagctatt     4560

gatttaggtt ttatgcctac gttaattatc aaatctgata aaggttatca agcatatttt     4620

gttttagaaa cgccagtcta tgtgacttca aaatcagaat ttaaatctgt caaagcagcc     4680

aaaataatct cgcaaaatat ccgagaatat tttggaaagt ctttgccagt tgatctaacg     4740

tgcaatcatt ttgggattgc tcgtatacca agaacggaca atgtagaatt ttttgatccc     4800

aattaccgtt attctttcaa agaatggcaa gattggtctt tcaaacaaac agataataag     4860

ggctttactc gttcaagtct aacggtttta agcggtacag aaggcaaaaa acaagtagat     4920

gaaccctggt ttaatctctt attgcacgaa acgaaatttt caggagaaaa gggtttagta     4980

gggcgcaata gcgttatgtt taccctctct ttagcctact ttagttcagg ctattcaatc     5040

gaaacgtgcg aatataatat gtttgagttt aataatcgat tagatcaacc cttagaagaa     5100

aaagaagtaa tcaaaattgt tagaagtgcc tattcagaaa actatcaagg ggctaatagg     5160

gaatacatta ccattctttg caaagcttgg gtatcaagtg atttaaccag taaagattta     5220

tttgtccgtc aagggtggtt taaattcaag aaaaaaagaa gcgaacgtca acgtgttcat     5280

ttgtcagaat ggaaagaaga tttaatggct tatattagcg aaaaaagcga tgtatacaag     5340

ccttatttag cgacgaccaa aaaagagatt agagaagtgc taggcattcc tgaacggaca     5400

ttagataaat tgctgaaggt actgaaggcg aatcaggaaa ttttctttaa gattaaacca     5460

ggaagaaatg gtggcattca acttgctagt gttaaatcat tgttgctatc gatcattaaa     5520

ttaaaaaaag aagaacgaga aagctatata aaggcgctga cagcttcgtt taatttagaa     5580

cgtacattta ttcaagaaac tctaaacaaa ttggcagaac gccccaaaac ggacccacaa     5640

ctcgatttgt ttagctacga tacaggctga aaataaaacc cgcactatgc cattacattt     5700

atatctatga tacgtgtttg tttttctttg ctggctagct taattgctta tatttacctg     5760

caataaagga tttcttactt ccattatact cccattttcc aaaaacatac ggggaacacg     5820

ggaacttatt gtacaggcca cctcatagtt aatggtttcg agccttcctg caatctcatc     5880

catggaaata tattcatccc cctgccggcc tattaatgtg acttttgtgc ccggcggata     5940

ttcctgatcc agctccacca taaattggtc catgcaaatt cggccggcaa ttttcaggcg     6000

ttttcccttc acaaggatgt cggtcccttt caattttcgg agccagccgt ccgcatagcc     6060

tacaggcacc gtcccgatcc atgtgtcttt ttccgctgtg tactcggctc cgtagctgac     6120

gctctcgcct tttctgatca gtttgacatg tgacagtgtc gaatgcaggg taaatgccgg     6180

acgcagctga aacggtatct cgtccgacat gtcagcagac gggcgaaggc catacatgcc     6240

gatgccgaat ctgactgcat taaaaaagcc ttttttcagc cggagtccag cggcgctgtt     6300

cgcgcagtgg accattagat tctttaacgg cagcggagca atcagctctt taaagcgctc     6360

aaactgcatt aagaaatagc ctctttcttt ttcatccgct gtcgcaaaat gggtaaatac     6420

ccctttgcac tttaaacgag ggttgcggtc aagaattgcc atcacgttct gaacttcttc     6480

ctctgttttt acaccaagtc tgttcatccc cgtatcgacc ttcagatgaa aatgaagaga     6540

accttttttc gtgtggcggg ctgcctcctg aagccattca acagaataac ctgttaaggt     6600

cacgtcatac tcagcagcga ttgccacata ctccggggga accgcgccaa gcaccaatat     6660

aggcgccttc aatccctttt tgcgcagtga aatcgcttca tccaaaatgg ccacggccaa     6720

gcatgaagca cctgcgtcaa gagcagcctt tgctgtttct gcatcaccat gcccgtaggc     6780

gtttgctttc acaactgcca tcaagtggac atgttcaccg atatgttttt tcatattgct     6840

gacattttcc tttatcgcgg acaagtcaat ttccgcccac gtatctctgt aaaaaggttt     6900

tgtgctcatg gaaaactcct ctcttttttc agaaaatccc agtacgtaat taagtatttg     6960

agaattaatt ttatattgat taatactaag tttacccagt tttcacctaa aaaacaaatg     7020

atgagataat agctccaaag gctaaagagg actataccaa ctatttgtta attaa          7075


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

His Cys Ile Arg Asn Lys Ser Val Ile Leu 
1               5                   10  


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST motif substitution

<400>  60

Gln Asp Asn Lys Arg 
1               5   


<210>  61
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric protein

<400>  61

Gly Ala Glu Gly Gly Glu Gly Val Ser Val Pro Pro Leu Leu Ser Leu 
1               5                   10                  15      


Arg Leu Leu Glu Leu Leu Arg Glu Ser Ala Arg Pro Leu Cys Ser Arg 
            20                  25                  30          


His Arg Val Trp His Arg Ser Trp Leu Gly His Gly Pro Pro Ser Ser 
        35                  40                  45              


Phe Gly His Leu Gln Trp Arg Asp His Pro Val Pro Arg Pro Pro Trp 
    50                  55                  60                  


Ala Val Pro Thr Trp Pro Arg Trp Arg Leu Tyr Ser Thr Leu Pro Glu 
65                  70                  75                  80  


Ala Pro Thr Gly Pro Pro Gly Arg Gly Lys Gly Asp Pro Asp Arg Arg 
                85                  90                  95      


Arg His Cys Pro Cys Phe Leu Glu Thr Pro Arg Trp Pro Arg Asp Ser 
            100                 105                 110         


Gly Asp Thr Leu His His Leu Val Cys Phe Gln Glu Gly Leu Asp Cys 
        115                 120                 125             


Gly Arg Val Ala Gly Ser Ser Pro Arg Arg Gly Asn His His Gly Phe 
    130                 135                 140                 


Ala Gly Lys Pro Gly Gly Arg Glu Arg Val His Cys Gln Asp Ile Cys 
145                 150                 155                 160 


Val Gln Arg Gly Gly Arg Arg Ala Leu Phe Lys Leu Arg Gly Ala Gly 
                165                 170                 175     


Arg Pro Pro Gln Gly Cys Phe Arg Val Glu Pro Glu Ala Gln Ala Phe 
            180                 185                 190         


Gly Phe Phe Gln Cys Gln Ser Leu Phe Arg Leu Leu Pro Ser Gly Pro 
        195                 200                 205             


Lys Val Asn Asp Gly His Arg Ser Arg Arg Trp His Ser Leu Asp Leu 
    210                 215                 220                 


Tyr Pro His Leu Cys Ser His Leu Asp Leu Pro Lys Gln Ser Gln Glu 
225                 230                 235                 240 


Val Ile Arg Leu Cys Glu Ser Ile Ser Glu Leu Leu Tyr Arg Met Gly 
                245                 250                 255     


Ser Pro Ala Leu Val Ile Leu Lys Ile Ser Ala Gln Leu Arg Ile Thr 
            260                 265                 270         


Ala Glu Val Cys Arg Leu Pro Thr Ala Ala Gln Gly Ala Pro Tyr Val 
        275                 280                 285             


Ile Thr Arg Leu Val Glu Ser Ser Pro Gln His Pro Leu Ala Leu Thr 
    290                 295                 300                 


Gly Glu Cys Cys Pro Ser Ala Trp Pro Thr Ala Arg Pro Leu Leu Thr 
305                 310                 315                 320 


Pro Ser Cys Ile Pro Cys Cys Asp Thr Asn Thr Ala Gly Ala Ala Arg 
                325                 330                 335     


Ser Ser Ser His Asp Leu Ser Gly Arg Arg Arg Ser Arg Gly Gly Ala 
            340                 345                 350         


Arg Cys Ser Ala Ser Gly Leu Cys Arg Gln Arg Thr Gln Asp Gly His 
        355                 360                 365             


Ser Leu Gly Ala Pro Asp Ser Gly Ser Gly Gly Ser Pro Pro Cys Cys 
    370                 375                 380                 


Ile Leu Lys Leu Leu Ala Ser Asp Trp Leu Gly Cys Thr Ser Gly Leu 
385                 390                 395                 400 


Val Ser Leu His Ser Arg Arg Gly Arg Arg Leu Glu Cys Leu Gln Ser 
                405                 410                 415     


Gln Pro Pro Glu Pro Met Thr Ser Thr Asn Pro Pro Ser Phe Pro Leu 
            420                 425                 430         


Arg Lys Arg Glu Ser Gly Arg Ile Pro Val Arg Lys Ser Ser Ser Gln 
        435                 440                 445             


Met Pro Ser Val Gly Leu Pro Gly Asp Phe Leu His Pro Pro Gln Ala 
    450                 455                 460                 


Gln His Thr Glu Arg His Thr Asp Asn Phe Gly Lys Tyr Asn Pro Ser 
465                 470                 475                 480 


Asp Tyr Leu Gln Gly Thr Ala Gly Pro Gly Leu Ala Leu Ala Gln Cys 
                485                 490                 495     


Ser Ala Thr Thr Val Cys Leu His Ser Lys Asp Gly His Pro Lys Leu 
            500                 505                 510         


Ser Leu Leu Val Leu Pro Thr Ser Gln Trp Trp Tyr Tyr Phe Leu Gly 
        515                 520                 525             


Pro Ala Ser Ser Ser Thr Cys Gly Gln Ser Ala Asn Ile Gln Gly Val 
    530                 535                 540                 


Gln Arg Ser Leu Glu Gly Trp Gln Thr Cys Trp Gly Arg Ser Arg Lys 
545                 550                 555                 560 


His Trp Gly Ser Thr Trp Asn Gly Ser Ala Arg Leu Ser Pro Gly Ser 
                565                 570                 575     


Thr Leu Trp Val Met Arg Ile Cys Leu Arg Ser Leu Gly Ile Ala Arg 
            580                 585                 590         


Thr Trp Leu Ser Cys Arg Ser Thr Ser Arg Lys Cys Ser Pro Ala Phe 
        595                 600                 605             


Pro Ala Ser Ser Gly Arg Pro Gly Arg Val Gly Pro Thr Gly Glu Lys 
    610                 615                 620                 


Arg Arg His Gly Gly Gln Arg Thr Glu Arg His Cys Gly Pro Pro Trp 
625                 630                 635                 640 


Lys Asn Trp Ser His Trp Arg Lys Arg 
                645                 


<210>  62
<211>  2004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding chimeric protein

<400>  62
ggtgcggaag gtggtgaggg cgtaagtgtt cctccacttt tatctcttcg tttgttagaa       60

cttttgcgtg aatctgcacg tccgctttgt tctcgtcacc gtgtatggca tcgttcatgg      120

ttaggacatg gtccaccaag ttcttttggt cacctacaat ggcgtgacca ccctgtacca      180

agaccaccat gggctgttcc aacatggcct cgctggcgct tatacagtac gcttcctgaa      240

gcgccgactg gcccaccagg tcgtggaaaa ggagacccag accgtcgtcg tcactgtcca      300

tgtttccttg agactccacg ctggccacgc gattcaggag atactttaca ccatttagta      360

tgttttcaag aaggtctaga ttgtggacgt gttgctggta gcagccctcg tcgtggtaat      420

catcatggat ttgcaggaaa accaggtggt cgtgaacgcg tgcactgtca agacatctgc      480

gttcagcgcg gtggacgccg tgcacttttc aaactacgcg gcgctggccg tccacctcaa      540

ggatgtttcc gtgtagaacc tgaagcacaa gcattcggtt ttttccaatg tcaatcactt      600

ttccgtcttc ttcctagtgg tccaaaagtt aatgacggtc atcgttcacg tcgctggcac      660

agccttgatt tatatccaca tttatgtagt cacttggatc ttcctaaaca atctcaagaa      720

gtaatccgtc tttgtgaatc tattagtgaa ttactttatc gtatgggttc tccagctctg      780

gtaattttga aaatctcagc tcaacttcgt atcactgcag aagtatgccg tttacctact      840

gcagctcaag gcgcaccata cgttattact cgtttagttg aaagctctcc tcaacaccca      900

ttagcattaa ctggtgaatg ttgtccgtct gcatggccaa cagctcgtcc actattaaca      960

ccttcttgca ttccatgctg tgacacaaat acagctggag cagctagatc atcctcacat     1020

gatttatctg gacgtcgtcg ttcacgtggt ggcgctcgtt gttcagcatc tggtttgtgt     1080

cgccaacgta cacaagacgg ccattcttta ggagcaccag atagtggctc tggaggttcc     1140

cctccatgtt gcattttaaa acttcttgca agtgattggt taggatgtac gtcaggttta     1200

gtatctctac attctcgtcg aggtcgtcgt cttgaatgtt tacaatctca accaccagaa     1260

ccaatgactt ccacaaatcc tccaagtttt cctttacgta agcgtgaatc gggtcgtatt     1320

ccagttcgca aatcttctag ccaaatgcca tcagtaggcc taccgggtga ttttttacac     1380

cctcctcaag ctcaacacac agaacgtcac actgacaact tcggcaaata caacccaagc     1440

gattatttgc agggtactgc tggtccaggc ttagcactag cacaatgttc tgctacgaca     1500

gtttgtcttc atagtaaaga tggacaccca aaattatctt tattagtcct tccaacaagc     1560

caatggtggt attacttttt aggtccagct tcatcttcta cttgtggtca atctgcaaat     1620

attcaaggcg ttcaacgcag tttagaaggc tggcaaacat gttggggccg ttcccgtaag     1680

cactggggta gcacttggaa tggctccgca agattgtccc caggatctac cctttgggtt     1740

atgcgtattt gtttacgtag tttgggcatt gcacgtacat ggttaagctg tcgttcaacg     1800

tctcgtaaat gttctcccgc attcccagcg tcatctggtc gtccaggccg tgttggtcca     1860

accggcgaaa aacgtcgcca cggaggtcaa cgcaccgaac gtcactgcgg tccaccatgg     1920

aaaaactgga gccattggcg taaacgcgct cgttctatca ttaacttcga aaaattatct     1980

catcaccatc atcaccatta ataa                                            2004


<210>  63
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric protein

<400>  63

Asn Ile Gln Gly Val Gln Arg Ser Leu Glu Gly Trp Gln Thr Cys Trp 
1               5                   10                  15      


Gly Arg Ser Arg Lys His Trp Gly Ser Thr Trp Asn Gly Ser Ala Arg 
            20                  25                  30          


Leu Ser Pro Gly Ser Thr Leu Trp Val Met Arg Ile Cys Leu Arg Ser 
        35                  40                  45              


Leu Gly Ile Ala Arg Thr Trp Leu Ser Cys Arg Ser Thr Ser Arg Lys 
    50                  55                  60                  


Cys Ser Pro Ala Phe Pro Ala Ser Ser Ser Thr Leu Pro Glu Ala Pro 
65                  70                  75                  80  


Thr Gly Pro Pro Gly Arg Gly Lys Gly Asp Pro Asp Arg Arg Arg His 
                85                  90                  95      


Cys Pro Cys Phe Leu Glu Thr Pro Arg Trp Pro Arg Asp Ser Gly Asp 
            100                 105                 110         


Thr Leu His His Leu Val Cys Phe Gln Glu Gly Leu Asp Cys Gly Arg 
        115                 120                 125             


Val Ala Gly Ser Ser Pro Arg Arg Gly Asn His His Gly Phe Ala Gly 
    130                 135                 140                 


Lys Pro Gly Gly Arg Glu Arg Val His Cys Gln Asp Ile Cys Val Gln 
145                 150                 155                 160 


Arg Gly Gly Arg Arg Ala Leu Phe Lys Leu Arg Gly Ala Gly Arg Pro 
                165                 170                 175     


Pro Gln Gly Cys Phe Arg Val Glu Pro Glu Ala Gln Ala Phe Gly Phe 
            180                 185                 190         


Phe Gln Cys Gln Ser Leu Phe Arg Leu Leu Pro Ser Gly Pro Lys Val 
        195                 200                 205             


Asn Asp Gly His Arg Ser Arg Arg Trp His Ser Leu Asp Leu Tyr Pro 
    210                 215                 220                 


His Leu Cys Ser His Leu Asp Leu Pro Lys Gln Ser Gln Glu Val Ile 
225                 230                 235                 240 


Arg Leu 
        


<210>  64
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding chimeric protein

<400>  64
aacattcaag gtgtacaacg ttctctagaa ggttggcaaa catgttgggg tcgttctcgt       60

aagcactggg gaagcacatg gaacggctct gctcgtttat ctccaggttc tacgttatgg      120

gtaatgcgta tctgtctacg ttccctaggt atcgcgcgta cttggttaag ctgccgctcc      180

acttctcgca aatgttctcc agcatttccg gcatcgtcat ctactctacc agaagctcca      240

actggaccac caggtcgtgg taaaggcgat ccagaccgtc gtcgtcactg tccatgtttc      300

ttagaaactc cacgttggcc aagagatagc ggagacacat tgcatcatct agtatgtttc      360

caagaaggtt tagactgtgg tcgtgttgca ggttccagcc cacgtagagg taaccaccac      420

ggcttcgccg gtaaaccagg tggtcgtgaa cgtgttcatt gccaagatat ctgtgtacaa      480

cgtggaggtc gtcgtgcttt atttaaatta cgaggagcgg gtcgtcctcc acaaggttgt      540

tttcgcgttg aaccagaagc acaagcattt ggattctttc agtgtcaatc tcttttccgt      600

cttttgccta gtggaccaaa agtaaatgac ggacatcgct ctcggcgttg gcactcatta      660

gatttgtatc ctcatctttg tagtcatcta gatctaccaa aacaatctca agaagtaatt      720

cgtcttgctc gttctatcat taacttcgaa aaattatctc atcaccatca tcaccattaa      780

taa                                                                    783


<210>  65
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric protein

<400>  65

Asp Ala Leu Val Lys Asp Ser Glu Glu Asn Cys Lys Asn Trp Ser Asn 
1               5                   10                  15      


Ser Lys Arg Arg Leu Gln Lys Lys Lys Ala Pro Ser Arg Ser Gly Met 
            20                  25                  30          


Ser Glu Arg Asn Asp Leu Phe Ser Phe Thr Phe Pro Arg Pro Asp Leu 
        35                  40                  45              


Ala Cys Gly Ala Thr Trp Ile Arg Arg Asp Asp Thr Trp Gly Gly Gly 
    50                  55                  60                  


Asn Arg Asp Leu Asn Pro Val Gly Lys Gln Phe Lys Glu Trp His Cys 
65                  70                  75                  80  


Ser Leu Cys Ser Val Cys Ala Arg Asn Ala Ile Asn Met Glu Tyr Thr 
                85                  90                  95      


Ile Asp Ile Phe Phe Cys Pro Asn Leu Val Ala Ala Leu Glu Thr Ile 
            100                 105                 110         


Gln Asn Met Ser Ile Lys Arg Leu Tyr Ser Ile Pro Ser Thr Glu Lys 
        115                 120                 125             


Lys Glu Asn Leu Trp Thr Lys Phe Ile Leu Ala Arg Gly Gly Glu Glu 
    130                 135                 140                 


Gly Gly Ile Arg Thr Glu Asp Phe Phe Ala Ala Leu Asp Leu Lys Ala 
145                 150                 155                 160 


Cys Pro Pro Ser Pro Ser Ala Gly Ser Trp Thr Glu Asp Ile Lys Leu 
                165                 170                 175     


Glu Glu Lys Lys Lys Asn Pro Ser Arg Asn Gly Ser His Leu Ile Ala 
            180                 185                 190         


Val Thr Val Phe Leu Trp Asp Phe Val Leu Tyr Val Pro Gln Ala Ser 
        195                 200                 205             


Ile Ile Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg Glu Gly Gln Phe 
    210                 215                 220                 


Thr Ala Leu Ser Asp Gly Val Asp Lys Gln Met Thr Gly Asn Phe Pro 
225                 230                 235                 240 


Gln Glu Ile Arg Ser Phe Lys Cys Trp Thr Leu Asp Thr Leu His Pro 
                245                 250                 255     


Asp Val Lys Lys Tyr Ile Ser Asp His Met Lys Val His Ser Pro Ser 
            260                 265                 270         


Pro Cys Leu Ser Tyr Lys Gln Gln Ser His Ser Asn Leu Lys Lys Ile 
        275                 280                 285             


Ser Phe Ser Ser Phe Ser Thr Tyr Leu Cys Pro Tyr Leu Thr Met Asp 
    290                 295                 300                 


Gln Ser Ala Lys Ser Ile Lys Glu Lys Lys Asn Met Lys Tyr Trp Ser 
305                 310                 315                 320 


Cys Cys Arg Arg Lys Asn Phe Arg Phe Arg Gly Gly Leu Arg Arg Arg 
                325                 330                 335     


Gly Ser Met Ala Pro Leu Arg Phe Ser Gly Val Ala Gln Gln Pro Leu 
            340                 345                 350         


Ser Asn Gly Ala Ile Arg Glu Leu Ser Ala Lys Ala Cys Thr Thr Glu 
        355                 360                 365             


Thr Val Ser Phe Leu Arg Lys Lys Lys Val Lys Leu Arg Ile Ile Tyr 
    370                 375                 380                 


Gly Glu Glu Asn Trp Arg Asn Arg Arg Lys Arg Ser Gln Leu Asp Val 
385                 390                 395                 400 


Met Glu Gln Leu Glu Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
                405                 410                 415     


Pro Pro Cys Val Phe Leu Leu Asn Gln Pro Val Gly Asn His Pro Ile 
            420                 425                 430         


Pro Gly Gly Asn Arg Pro Ser Gln Gln Thr Val Glu Ile Lys Gly Lys 
        435                 440                 445             


Ala Gln Lys Cys Phe Ser Phe Ser Met Ile Phe Ser Phe Leu Pro Tyr 
    450                 455                 460                 


Ser Met Ser Tyr Ser Gly His Phe 
465                 470         


<210>  66
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding chimeric protein

<400>  66
gacgctcttg taaaagattc agaagaaaac tgtaagaact ggtcaaatag taaacgtcgc       60

cttcaaaaga aaaaagcacc atcccgttct ggtatgtccg aacgcaatga tttatttagt      120

ttcacattcc cacgccctga ccttgcgtgc ggcgcaacct ggatccgtcg tgatgatact      180

tggggcgggg gtaatcgcga tttaaatcca gttgggaaac aattcaaaga atggcattgc      240

tctctttgta gtgtttgtgc acgtaacgct attaacatgg aatatacgat cgacattttt      300

ttttgtccta acttagtagc tgctttagaa actattcaaa acatgagcat taaacgttta      360

tattctatcc catccactga aaaaaaagaa aacttatgga caaaattcat tttagcgcgt      420

ggtggtgaag aagggggaat tcgtacagaa gatttctttg ctgcacttga tttaaaagct      480

tgtccaccaa gcccatcagc aggcagttgg acggaagaca tcaaacttga agaaaaaaaa      540

aaaaacccta gccgtaacgg ctctcatcta attgcagtaa cagtattctt gtgggatttt      600

gtgttatatg tacctcaagc atcgattatt gaggacgatg aaagtggtac agaaaacaga      660

gaaggtcaat tcactgctct ttcagacggt gtagataaac aaatgacagg aaattttcct      720

caagaaatcc gttccttcaa atgttggact ttagatacac tacatccaga tgttaaaaaa      780

tatatctcag accatatgaa agttcattct ccttcaccat gtcttagcta caaacaacaa      840

tctcattcta acttaaaaaa aatctcattc tcaagcttct ctacatacct atgtccatat      900

ttaacgatgg accaatctgc aaaatctata aaagaaaaaa agaatatgaa atactggtct      960

tgttgtcgcc gcaaaaactt tcgttttcgt ggtggtctgc gtcgtcgtgg atctatggcg     1020

cctctacgtt tcagtggagt tgctcaacag ccactttcta atggtgctat ccgcgaactt     1080

agtgctaaag catgcacaac agaaacagtg agtttccttc gtaagaaaaa agttaaattg     1140

cgtattattt atggtgaaga aaattggcgc aaccgtcgta aacgctctca acttgacgta     1200

atggaacaac ttgaaccaaa atgtccacct aaatgtcctc caaaatgtcc accttgtgtt     1260

ttcttattaa accaacctgt tggcaaccac ccaatccctg gaggtaaccg tccatcccaa     1320

caaacagtag aaatcaaagg gaaagcacaa aaatgtttct ctttttctat gattttctcc     1380

tttttacctt atagtatgtc ttactccggc cacttcgctc gttctatcat taacttcgaa     1440

aaattatctc atcaccatca tcaccattaa taa                                  1473


<210>  67
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Detoxified listeriolysin O

<400>  67

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Ala Thr Gly Leu Ala Trp Glu Ala Ala Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  68

Phe Met Val Ala Val Ala His Val Ala Ala Phe Leu Leu Glu Asp Arg 
1               5                   10                  15      


Ala Val Cys Val 
            20  


<210>  69
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  69

Ala Glu Asn Val Glu Gln Val Leu Val Thr Ser Ile Gln Gly Ala Val 
1               5                   10                  15      


Asp Tyr Pro Asp Pro 
            20      


<210>  70
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  70

Ser Phe Lys Lys Lys Phe Glu Glu Cys Gln His Asn Ile Ile Lys Leu 
1               5                   10                  15      


Gln Asn Gly His Thr 
            20      


<210>  71
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  71

Ser Ala Leu Ile Glu Ser Leu Asn Gln Lys Thr Gln Ser Thr Gly Asp 
1               5                   10                  15      


His Pro Gln Pro Thr 
            20      


<210>  72
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  72

Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr Ala Asp Leu 
1               5                   10                  15      


Arg Ser Asn Thr Gly 
            20      


<210>  73
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  73

His Thr Leu Leu Glu Ile Thr Glu Glu Ser Gly Ala Val Leu Val Asp 
1               5                   10                  15      


Lys Ser Asp Ser Asp 
            20      


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  74

Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asp Lys Leu Phe Cys Gln 
1               5                   10                  15      


Leu Ala Lys Thr Cys 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  75

Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Ala Met Phe Thr Ala Thr 
1               5                   10                  15      


Met Pro Pro Ala Val 
            20      


<210>  76
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  76

Ala Ala Pro Ser Ala Ala Ser Ser Pro Ala Asp Val Gln Ser Leu Lys 
1               5                   10                  15      


Lys Ala Met Ser Ser 
            20      


<210>  77
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  77

Ser Gln Leu Phe Ser Leu Asn Pro Arg Gly Arg Ser Leu Val Thr Ala 
1               5                   10                  15      


Gly Arg Ile Asp Arg 
            20      


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  78

Ser Leu Ala Arg Gly Pro Leu Ser Glu Ala Gly Leu Ala Leu Phe Asp 
1               5                   10                  15      


Pro Tyr Ser Lys Glu 
            20      


<210>  79
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  79

Gln Lys Lys Leu Cys His Leu Ser Ser Thr Gly Leu Pro Arg Glu Thr 
1               5                   10                  15      


Ile Ala Ser Leu Pro 
            20      


<210>  80
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  80

Leu Thr Ala Ser Asn Met Glu Gly Lys Ser Trp Pro Ser Glu Val Leu 
1               5                   10                  15      


Val Cys Thr Thr Ser 
            20      


<210>  81
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  81

Tyr Ala Ala Gln Gln His Glu Thr Phe Leu Thr Asn Gly Asp Arg Ala 
1               5                   10                  15      


Gly Phe Leu Ile Gly 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  82

Gln Ala Lys Val Pro Phe Ser Glu Glu Thr Gln Asn Leu Ile Leu Pro 
1               5                   10                  15      


Tyr Ile Ser Asp Met 
            20      


<210>  83
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  83

Cys Asn Arg Ala Gly Glu Lys His Cys Phe Ser Ser Asn Glu Ala Ala 
1               5                   10                  15      


Arg Asp Phe Gly Gly 
            20      


<210>  84
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  84

Arg Asn Pro Gln Phe Leu Asp Pro Val Leu Ala Tyr Leu Met Lys Gly 
1               5                   10                  15      


Leu Cys Glu Lys Pro 
            20      


<210>  85
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  85

Leu Glu Cys Glu Arg Gly Lys Gln Glu Ala Lys Leu Leu Ala Glu Arg 
1               5                   10                  15      


Ser Arg Phe Glu Asp 
            20      


<210>  86
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  86

Ala Pro Leu Glu Trp Leu Arg Tyr Phe Asp Lys Lys Glu Leu Glu Leu 
1               5                   10                  15      


Met Leu Cys Gly Met 
            20      


<210>  87
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  87

Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Ala Met Asp Glu Met Glu 
1               5                   10                  15      


Phe Thr Glu Ala Glu 
            20      


<210>  88
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  88

Asp Glu Val Ala Leu Val Glu Gly Val Gln Ser Leu Gly Phe Thr Tyr 
1               5                   10                  15      


Leu Arg Leu Lys Asp 
            20      


<210>  89
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  89

Asp Phe Ser Gln Leu Gln Arg Asn Ile Leu Pro Ser Asn Pro Arg Val 
1               5                   10                  15      


Thr Arg Phe His Ile 
            20      


<210>  90
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  90

Ile Ser Thr Asn Gly Ser Phe Ile Arg Leu Leu Asp Ala Phe Lys Gly 
1               5                   10                  15      


Val Val Met His Thr 
            20      


<210>  91
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  91

Ile Thr Pro Pro Thr Thr Thr Thr Lys Lys Ala Arg Val Ser Thr Pro 
1               5                   10                  15      


Lys Pro Ala Thr Pro 
            20      


<210>  92
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  92

Asn Tyr Asn Thr Ser His Leu Asn Asn Asp Val Trp Gln Ile Phe Glu 
1               5                   10                  15      


Asn Pro Val Asp Trp 
            20      


<210>  93
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  93

Gln Lys Thr Leu His Asn Leu Leu Arg Lys Val Val Pro Ser Phe Ser 
1               5                   10                  15      


Ala Glu Ile Glu Arg 
            20      


<210>  94
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  94

Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg His Gly Thr 
1               5                   10                  15      


Thr His Ser Leu Val 
            20      


<210>  95
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  95

Gly Ile Asp Lys Leu Thr Gln Leu Lys Lys Pro Phe Leu Val Asn Asn 
1               5                   10                  15      


Lys Ile Asn Lys Ile 
            20      


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  96

Gly Thr Thr Ile Leu Asn Cys Phe His Asp Val Leu Ser Gly Lys Leu 
1               5                   10                  15      


Ser Gly Gly Ser 
            20  


<210>  97
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  97

Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser Pro Glu Leu 
1               5                   10                  15      


Asn Ser Thr Asp Gln 
            20      


<210>  98
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  98

Pro Ala Leu Val Glu Glu Tyr Leu Glu Arg Gly Asn Phe Val Ala Asn 
1               5                   10                  15      


Asp Leu Asp Trp Leu 
            20      


<210>  99
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  99

Glu Leu Lys Ala Cys Lys Pro Asn Gly Lys Arg Asn Pro Tyr Cys Glu 
1               5                   10                  15      


Val Ser Met Gly Ser 
            20      


<210>  100
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  100

Ser Pro Phe Pro Ala Ala Val Ile Leu Arg Asp Ala Leu His Met Ala 
1               5                   10                  15      


Arg Gly Leu Lys Tyr 
            20      


<210>  101
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  101

Gln Gln Leu Asp Thr Tyr Ile Leu Lys Asn Val Val Ala Phe Ser Arg 
1               5                   10                  15      


Thr Asp Lys Tyr Arg 
            20      


<210>  102
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  102

Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu Glu Val 
1               5                   10                  15      


Glu Glu Thr Glu Leu 
            20      


<210>  103
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  103

Ala Phe Phe Ile Asn Phe Ile Ala Ile Tyr His His Ala Ser Arg Ala 
1               5                   10                  15      


Ile Pro Phe Gly Thr 
            20      


<210>  104
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  104

Gly Leu Ala Leu Pro Asn Asn Tyr Cys Asp Val Cys Leu Gly Asp Ser 
1               5                   10                  15      


Lys Ile Asn Lys Lys 
            20      


<210>  105
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  105

Glu Gly Gln Ile Ser Ile Ala Lys Tyr Glu Asn Cys Pro Lys Asp Asn 
1               5                   10                  15      


Pro Met Tyr Tyr Cys 
            20      


<210>  106
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  106

Asn Phe Lys Arg Lys Arg Val Ala Ala Phe Gln Lys Asn Leu Ile Glu 
1               5                   10                  15      


Met Ser Glu Leu Glu 
            20      


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  107

Lys Met Lys Gly Glu Leu Gly Met Met Leu Ile Leu Gln Asn Val Ile 
1               5                   10                  15      


Gln Lys Thr Thr Thr 
            20      


<210>  108
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  108

Ser Ile Glu Cys Lys Gly Ile Asp Lys Glu Ile Asn Glu Ser Lys Asn 
1               5                   10                  15      


Thr His Leu Asp Ile 
            20      


<210>  109
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  109

Glu Leu Glu Ala Ala Ile Glu Thr Val Val Cys Thr Phe Phe Thr Phe 
1               5                   10                  15      


Ala Gly Arg Glu Gly 
            20      


<210>  110
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  110

Ser Leu Ser His Arg Glu Arg Glu Gln Met Lys Ala Thr Leu Asn Tyr 
1               5                   10                  15      


Glu Asp His Cys Phe 
            20      


<210>  111
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  111

His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro Gly Pro Met 
1               5                   10                  15      


Val Val Phe Ala Thr 
            20      


<210>  112
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  112

Ile Thr Ser Asn Phe Val Ile Pro Ser Glu Tyr Trp Val Glu Glu Lys 
1               5                   10                  15      


Glu Glu Lys Gln Lys 
            20      


<210>  113
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  113

Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Val Met Ser Arg Glu Thr 
1               5                   10                  15      


Thr Asp Thr Asp Thr 
            20      


<210>  114
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  114

His Leu Leu Gly Arg Leu Ala Ala Ile Val Gly Lys Gln Val Leu Leu 
1               5                   10                  15      


Gly Arg Lys Val Val 
            20      


<210>  115
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  115

His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val His Asn Trp 
1               5                   10                  15      


Asp Phe Glu Pro Arg 
            20      


<210>  116
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  116

Ser Met Asp His Lys Thr Gly Thr Ile Ala Met Gln Asn Thr Thr Gln 
1               5                   10                  15      


Leu Arg Ser Arg Tyr 
            20      


<210>  117
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant peptide

<400>  117

Gln Pro Leu Arg Arg Leu Val Leu His Val Val Ser Ala Ala Gln Ala 
1               5                   10                  15      


Glu Arg Leu Ala Arg 
            20      


<210>  118
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  118
ccatctttcc aagaattcgt tgattgggaa aacgtttctc cagaattaaa ctctacagat       60

caaggtggtg gaggaaaagc atatttacca gttaacgaat ctttcgcatt cacagcagat      120

ttacgttcta acacaggtgg tggaggtgga cgtaacccac aattcttaga tccagtttta      180

gcatatttaa tgaaaggttt atgtgaaaaa ccaggtggag gaggtaaagc attcttacat      240

tggtatacag gtgaagcaat ggatgaaatg gaattcacag aagcagaagg aggtggtgga      300

gatttctctc aattacaacg taacatttta ccatctaacc cacgtgttac acgtttccat      360

attggaggag gtggtattac accaccaaca acaacaacaa aaaaagcacg tgtttctaca      420

ccaaaaccag caacaccagg aggtggaggt aactataaca catctcattt aaacaacgat      480

gtttggcaaa ttttcgaaaa cccagttgat tggggaggag gaggtcatat taaagcattc      540

gatcgtacat tcgcaaacaa cccaggtcca atggttgttt tcgcaacagg aggaggtgga      600

attacatcta acttcgttat tccatctgaa tattgggttg aagaaaaaga agaaaaacaa      660

aaaggaggtg gaggaggttt agttacattc caagcattca ttgatgttat gtctcgtgaa      720

acaacagata cagatacagg tggaggagga cattggaacg atttagcagt tattccagca      780

ggtgttgttc ataactggga tttcgaacca cgtggaggag gaggacaacc attacgtcgt      840

ttagttttac atgttgtttc tgcagcacaa gcagaacgtt tagcacgtgc acgttctatt      900

attaacttcg aaaaattatc tcatcatcat catcatcatt aataa                      945


<210>  119
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  119
ccatctttcc aagaattcgt tgattgggaa aacgtttctc cagaattaaa ctctacagat       60

caaggtggtg gaggattcat ggttgcagtt gcacatgttg cagcattctt attagaagat      120

cgtgcagttt gtgttggagg aggaggagca gaaaacgttg aacaagtttt agttacatct      180

attcaaggtg cagttgatta tccagatcca ggtggaggtg gatctttcaa aaaaaaattc      240

gaagaatgtc aacataacat tattaaatta caaaacggtc atacaggtgg aggaggttct      300

gcattaattg aatctttaaa ccaaaaaaca caatctacag gtgatcatcc acaaccaaca      360

ggaggtggtg gaaaagcata tttaccagtt aacgaatctt tcgcattcac agcagattta      420

cgttctaaca caggtggagg aggtggtcat acattattag aaattacaga agaatctggt      480

gcagttttag ttgataaatc tgattctgat ggaggtggag gttctgttat gtgtacatat      540

tctccaccat tagataaatt attctgtcaa ttagcaaaaa catgtggagg aggaggtgaa      600

tctggtaaac ataaatatcg tcaaacagca atgttcacag caacaatgcc accagcagtt      660

ggaggaggtg gagcagcacc atctgcagca tcttctccag cagatgttca atctttaaaa      720

aaagcaatgt cttctggagg tggaggatct caattattct ctttaaaccc acgtggtcgt      780

tctttagtta cagcaggtcg tattgatcgt ggtggaggag gatctttagc acgtggtcca      840

ttatctgaag caggtttagc attattcgat ccatattcta aagaaggagg aggaggacaa      900

aaaaaattat gtcatttatc ttctacaggt ttaccacgtg aaacaattgc atctttacca      960

ggtggtggag gattaacagc atctaacatg gaaggtaaat cttggccatc tgaagtttta     1020

gtttgtacaa catctggtgg aggtggatat gcagcacaac aacatgaaac attcttaaca     1080

aacggtgatc gtgcaggttt cttaattggt ggtggaggag gtcaagcaaa agttccattc     1140

tctgaagaaa cacaaaactt aattttacca tatatttctg atatgggagg tggtggatgt     1200

aaccgtgcag gtgaaaaaca ttgtttctct tctaacgaag cagcacgtga tttcggtggt     1260

ggaggaggtg gtcgtaaccc acaattctta gatccagttt tagcatattt aatgaaaggt     1320

ttatgtgaaa aaccaggagg tggaggttta gaatgtgaac gtggtaaaca agaagcaaaa     1380

ttattagcag aacgttctcg tttcgaagat ggaggaggag gtgcaccatt agaatggtta     1440

cgttatttcg ataaaaaaga attagaatta atgttatgtg gtatg                     1485


<210>  120
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid DNA

<400>  120
ccatctttcc aagaattcgt tgattgggaa aacgtttctc cagaattaaa ctctacagat       60

caagcagaaa acgttgaaca agttttagtt acatctattc aaggtgcagt tgattatcca      120

gatccatctt tcaaaaaaaa attcgaagaa tgtcaacata acattattaa attacaaaac      180

ggtcatacat ctgcattaat tgaatcttta aaccaaaaaa cacaatctac aggtgatcat      240

ccacaaccaa caaaagcata tttaccagtt aacgaatctt tcgcattcac agcagattta      300

cgttctaaca caggtcatac attattagaa attacagaag aatctggtgc agttttagtt      360

gataaatctg attctgattc tgttatgtgt acatattctc caccattaga taaattattc      420

tgtcaattag caaaaacatg tgaatctggt aaacataaat atcgtcaaac agcaatgttc      480

acagcaacaa tgccaccagc agttgcagca ccatctgcag catcttctcc agcagatgtt      540

caatctttaa aaaaagcaat gtcttcttct caattattct ctttaaaccc acgtggtcgt      600

tctttagtta cagcaggtcg tattgatcgt tctttagcac gtggtccatt atctgaagca      660

ggtttagcat tattcgatcc atattctaaa gaacaaaaaa aattatgtca tttatcttct      720

acaggtttac cacgtgaaac aattgcatct ttaccattaa cagcatctaa catggaaggt      780

aaatcttggc catctgaagt tttagtttgt acaacatctt atgcagcaca acaacatgaa      840

acattcttaa caaacggtga tcgtgcaggt ttcttaattg gtcaagcaaa agttccattc      900

tctgaagaaa cacaaaactt aattttacca tatatttctg atatgtgtaa ccgtgcaggt      960

gaaaaacatt gtttctcttc taacgaagca gcacgtgatt tcggtggtcg taacccacaa     1020

ttcttagatc cagttttagc atatttaatg aaaggtttat gtgaaaaacc attagaatgt     1080

gaacgtggta aacaagaagc aaaattatta gcagaacgtt ctcgtttcga agatgcacca     1140

ttagaatggt tacgttattt cgataaaaaa gaattagaat taatgttatg tggtatgcca     1200

gcattagttg aagaatattt agaacgtggt aacttcgttg caaacgattt agattggtta     1260

gaattaaaag catgtaaacc aaacggtaaa cgtaacccat attgtgaagt ttctatgggt     1320

tcttctccat tcccagcagc agttatttta cgtgatgcat tacatatggc acgtggttta     1380

aaatatcaac aattagatac atatatttta aaaaacgttg ttgcattctc tcgtacagat     1440

aaatatcgtt ctttcgttgg tcaaacacgt gttttaatga ttaacggtga agaagttgaa     1500

gaaacagaat tagcattctt cattaacttc attgcaattt atcatcatgc atctcgtgca     1560

attccattcg gtacaggttt agcattacca aacaactatt gtgatgtttg tttaggtgat     1620

tctaaaatta acaaaaaaga aggtcaaatt tctattgcaa aatatgaaaa ctgtccaaaa     1680

gataacccaa tgtattattg taacttcaaa cgtaaacgtg ttgcagcatt ccaaaaaaac     1740

ttaattgaaa tgtctgaatt agaaaaaatg aaaggtgaat taggtatgat gttaatttta     1800

caaaacgtta ttcaaaaaac aacaacagca cgttctatta ttaacttcga aaaattatct     1860

catcatcatc atcatcatta ataa                                            1884


