                               SEQUENCE LISTING

<110> SIAMAB THERAPEUTICS, INC.
      THE GENERAL HOSPITAL CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TARGETING CANCER STEM CELLS

<130> 2033.1023PCT

<140> PCT/US2017/XXXXXX
<141> 2017-01-27

<150> 62/345,470 
<151> 2016-06-03

<150> 62/293,872 
<151> 2016-02-11

<150> 62/287,679 
<151> 2016-01-27

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Pro Gly Asn Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Cys 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Arg Ser Leu Leu Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 3
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Any amino acid

<400> 3
Gln Val Gln Leu Gln Gln Ser Asp Xaa Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Ser Pro Gly Asn Asp Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Ser Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Arg Ser Leu Ser Thr Pro Tyr Trp Gly Gln Gly Thr Leu Xaa Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 4
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Arg 
            20                  25                  30          


Gly Asn His Lys Asn Tyr Leu Thr Trp Tyr Arg Gln Lys Pro Gly Leu 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210> 5
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210> 7
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Pro Gly Asn Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Cys 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Arg Ser Leu Leu Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
    210                 215                 220                 


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
                245                 250                 255     


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
            260                 265                 270         


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
    290                 295                 300                 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
            340                 345                 350         


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
        355                 360                 365             


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
    370                 375                 380                 


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
                405                 410                 415     


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445     


<210> 8
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210> 9
<211> 1401
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

caggttcagc tgcagcagtc tgacgctgag ttggtgaaac ctggggcttc agtgaagata      120

tcctgcaagg cttctggcta caccttcact gaccatgcta ttcactgggt gaagcaaaag      180

cctgaacagg gcctggactg gattggatat atttctcccg gaaatggtga tattaagtac      240

aatgagaagt tcaaggacaa ggtcacactg actgcagaca aatcctccag cactgcctgc      300

atgcacctca acagcctgac atctgaggat tctgcagtgt atttctgcaa aagatcccta      360

ctagctcttg actactgggg ccaaggcacc actctcacag tctcctcagc taaaacaaca      420

gccccatcgg tctatccact ggcccctgtg tgtggagata caactggctc ctcggtgact      480

ctaggatgcc tggtcaaggg ttatttccct gagccagtga ccttgacctg gaactctggt      540

tccctgtcca gtggtgtgca caccttccca gctgtcctgc agtctgacct ctacaccctc      600

agctcaagcg tgactgtaac cagctcgacc tggcccagcc agtccatcac ctgcaatgtg      660

gcccacccgg caagcagcac caaggtggac aagaaaattg agcccagagg gcccacaatc      720

aagccctgtc ctccatgcaa atgcccagca cctaacctct tgggtggacc atccgtcttc      780

atcttccctc caaagatcaa ggatgtactc atgatctccc tgagccccat agtcacatgt      840

gtagtcgttg atgtgagcga ggatgaccca gatgtccaga tcagctggtt tgtgaacaac      900

gtggaagtgc acactgctca gacacagacg catagagagg attacaacag tactctccgg      960

gttgtcagtg ccctccccat ccagcaccag gactggatga gtggcaagga gttcaaatgc     1020

aaggtcaaca acaaagacct cccagcgccc atcgagagaa ccatctcaaa acccaaaggg     1080

tcagtaagag ctccacaggt atatgtcttg cctccaccag aagaggagat gactaagaaa     1140

caggtcactc tgacctgcat ggtcacagac ttcatgcctg aagacattta cgtggagtgg     1200

accaacaacg ggaaaacaga gctaaactac aagaacactg aaccagtcct ggactctgat     1260

ggttcttact tcatgtacag caagctgaga gtggagaaga agaactgggt ggagagaaat     1320

agctactcct gttcagtggt ccacgagggt ctgcacaatc accacacgac taagagcttc     1380

tcccggactc cgggtaaata g                                               1401


<210> 10
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgggc actaatatag cctggtatca acagaaacca      180

ggccgatctc ctaaagtact gatttactcg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      300

gaagacttga cagattattt ctgtcagcaa tatagcagct ttcctctcac gttcggtgtt      360

gggaccaagc tggagctgaa acgggcagat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttga                      705


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys Cys 
1               5                   10          


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210> 13
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      "KDEL" family motif peptide

<400> 13
Lys Asp Glu Leu 
1               


<210> 14
<211> 122
<212> PRT
<213> Lamos pacos

<400> 14
Met Ala Asn Val Gln Leu Asn Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Asp Ile Ser Pro Ser Gly Ala Val Lys Ala Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Arg 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Gly Glu Tyr 
                85                  90                  95      


Phe Cys Thr Lys Val Gln Ser Pro Arg Thr Arg Ile Pro Ala Pro Ser 
            100                 105                 110         


Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210> 15
<211> 122
<212> PRT
<213> Lamos pacos

<400> 15
Met Ala Asn Val Gln Leu Asn Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Glu Ile Ser Pro Ser Gly Ala Val Lys Ala Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Arg 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Gly Glu Tyr 
                85                  90                  95      


Phe Cys Thr Lys Val Gln Ser Pro Arg Thr Arg Ile Pro Ala Pro Ser 
            100                 105                 110         


Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210> 16
<211> 10
<212> PRT
<213> Homo sapiens

<400> 16
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


