
                                SEQUENCE LISTING

<110> Svenska Vaccinfabriken Produktion AB
      Sallberg, Matti
      Frelin, Lars

<120> CHIMERIC HEPATITIS D VIRUS ANTIGEN AND
  HEPATITIS B VIRUS PRE S1 GENES FOR USE ALONE OR IN VACCINES
  CONTANING HEPATITIS B VIRUS GENES
  

<130> SVF.002WO

<150> 62/288316           
<151> 2016-01-28  

<160> 116

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 47
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pre S1 A

<400> 1
Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His
 1               5                  10                  15      
Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp
            20                  25                  30          
Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
        35                  40                  45          


<210> 2
<211> 47
<212> PRT
<213> Artificial Sequence

<220> 
<223> PreS1 B

<400> 2
Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His
 1               5                  10                  15      
Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp
            20                  25                  30          
Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
        35                  40                  45          


<210> 3
<211> 639
<212> PRT
<213> Artificial Sequence

<220> 
<223> HDAg genotype 1 A

<400> 3
Ala Gly Cys Cys Gly Cys Ala Gly Cys Gly Ala Ala Ala Gly Cys Ala
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Ala Cys Cys Gly Cys Gly Gly Cys Gly Gly
            20                  25                  30          
Cys Cys Gly Cys Gly Ala Ala Gly Ala Ala Ala Thr Thr Cys Thr Gly
        35                  40                  45              
Gly Ala Ala Cys Ala Gly Thr Gly Gly Gly Thr Gly Gly Gly Cys Gly
    50                  55                  60                  
Cys Gly Cys Gly Cys Ala Ala Ala Ala Ala Ala Cys Thr Gly Gly Ala
65                  70                  75                  80  
Ala Gly Ala Ala Cys Thr Gly Gly Ala Ala Cys Gly Cys Gly Ala Thr
                85                  90                  95      
Cys Thr Gly Cys Gly Cys Ala Ala Ala Ala Thr Thr Ala Ala Ala Ala
            100                 105                 110         
Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Ala Ala Ala Ala Cys Thr
        115                 120                 125             
Gly Gly Ala Ala Gly Ala Ala Gly Ala Ala Ala Ala Cys Cys Cys Gly
    130                 135                 140                 
Thr Gly Gly Cys Thr Gly Gly Gly Cys Ala Ala Cys Ala Thr Thr Ala
145                 150                 155                 160 
Ala Ala Gly Gly Cys Ala Thr Thr Cys Thr Gly Gly Gly Cys Ala Ala
                165                 170                 175     
Ala Ala Ala Ala Gly Ala Thr Cys Gly Cys Gly Ala Ala Gly Gly Cys
            180                 185                 190         
Gly Ala Ala Gly Gly Cys Gly Cys Gly Cys Cys Gly Cys Cys Gly Gly
        195                 200                 205             
Cys Gly Ala Ala Ala Cys Gly Cys Gly Cys Gly Cys Gly Cys Gly Cys
    210                 215                 220                 
Gly Gly Ala Thr Cys Ala Gly Ala Thr Gly Gly Ala Ala Gly Thr Gly
225                 230                 235                 240 
Gly Ala Thr Ala Gly Cys Gly Gly Cys Cys Cys Gly Cys Gly Cys Ala
                245                 250                 255     
Ala Ala Cys Gly Cys Cys Cys Gly Thr Thr Thr Cys Gly Cys Gly Gly
            260                 265                 270         
Cys Gly Ala Ala Thr Thr Thr Ala Cys Cys Gly Ala Thr Ala Ala Ala
        275                 280                 285             
Gly Ala Ala Cys Gly Cys Cys Gly Cys Gly Ala Thr Cys Ala Thr Cys
    290                 295                 300                 
Gly Cys Cys Gly Cys Cys Gly Cys Ala Ala Ala Gly Cys Gly Cys Thr
305                 310                 315                 320 
Gly Gly Ala Ala Ala Ala Cys Ala Ala Ala Cys Gly Cys Ala Ala Ala
                325                 330                 335     
Cys Ala Gly Cys Thr Gly Ala Gly Cys Ala Gly Cys Gly Gly Cys Gly
            340                 345                 350         
Gly Cys Ala Ala Ala Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Ala
        355                 360                 365             
Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala
    370                 375                 380                 
Cys Thr Gly Cys Gly Cys Ala Ala Ala Cys Thr Gly Ala Cys Cys Gly
385                 390                 395                 400 
Ala Ala Gly Ala Ala Gly Ala Thr Gly Ala Ala Cys Gly Cys Cys Gly
                405                 410                 415     
Cys Gly Ala Ala Cys Gly Cys Cys Gly Cys Gly Thr Gly Gly Cys Gly
            420                 425                 430         
Gly Gly Cys Cys Cys Gly Cys Gly Cys Gly Thr Gly Gly Gly Cys Gly
        435                 440                 445             
Gly Cys Gly Thr Gly Ala Ala Cys Cys Cys Gly Cys Thr Gly Gly Ala
    450                 455                 460                 
Ala Gly Gly Cys Gly Gly Cys Ala Cys Cys Cys Gly Cys Gly Gly Cys
465                 470                 475                 480 
Gly Cys Gly Cys Cys Gly Gly Gly Cys Gly Gly Cys Gly Gly Cys Thr
                485                 490                 495     
Thr Thr Gly Thr Gly Cys Cys Gly Ala Gly Cys Ala Thr Gly Cys Ala
            500                 505                 510         
Gly Gly Gly Cys Gly Thr Gly Cys Cys Gly Gly Ala Ala Ala Gly Cys
        515                 520                 525             
Cys Cys Gly Thr Thr Thr Gly Cys Gly Cys Gly Cys Ala Cys Cys Gly
    530                 535                 540                 
Gly Cys Gly Ala Ala Gly Gly Cys Cys Thr Gly Gly Ala Thr Gly Thr
545                 550                 555                 560 
Gly Cys Gly Cys Gly Gly Cys Ala Ala Cys Cys Ala Gly Gly Gly Cys
                565                 570                 575     
Thr Thr Thr Cys Cys Gly Thr Gly Gly Gly Ala Thr Ala Thr Thr Cys
            580                 585                 590         
Thr Gly Thr Thr Thr Cys Cys Gly Gly Cys Gly Gly Ala Thr Cys Cys
        595                 600                 605             
Gly Cys Cys Gly Thr Thr Thr Ala Gly Cys Cys Cys Gly Cys Ala Gly
    610                 615                 620                 
Ala Gly Cys Thr Gly Cys Cys Gly Cys Cys Cys Gly Cys Ala Gly
625                 630                 635                 


<210> 4
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> HDAg genotype 1 B nucleic acid

<400> 4
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aagtgctgga acagtgggtg 60
aacggccgca aaaaactgga agaactggaa cgcgaactgc gccgcgcgcg caaaaaaatt 120
aaaaaactgg aagatgataa cccgtggctg ggcaacgtga aaggcattct gggcaaaaaa 180
gataaagatg gcgaaggcgc gccgccggcg aaacgcgcgc gcaccgatca gatggaaatt 240
gatagcggcc cgcgcaaacg cccgctgcgc ggcggcttta ccgatcgcga acgccaggat 300
catcgccgcc gcaaagcgct gaaaaacaaa aaaaaacagc tgagcgcggg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgaaa cgcctgaccc gcgaagatga agaacgcaaa 420
aaagaagaac atggcccgag ccgcctgggc gtgaacccga gcgaaggcgg cccgcgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcattc cggaaagccg ctttacccgc 540
accggcgaag gcctggatgt gcgcggcagc cgcggctttc cgcaggatat tctgtttccg 600
agcgatccgc cgtttagccc gcagagctgc cgcccgcag                        639

<210> 5
<211> 141
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreS1 derived sequence is preS1

<400> 5
ggcaccaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 60
gcgtttcgcg cgaacagcgc gaacccggat tgggatttta acccgaacaa agatacctgg 120
ccggatgcga acaaagtggg c                                           141

<210> 6
<211> 141
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreS1 B

<400> 6
ggccagaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 60
gcgtttcgcg cgaacaccgc gaacccggat tgggatttta acccgaacaa agatacctgg 120
ccggatgcga acaaagtggg c                                           141

<210> 7
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A nucleic acid

<400> 7
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct 60
ggacct                                                            66

<210> 8
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> HDAg gentotype 2 A (wt)

<400> 8
atgagccaga gcgaaacccg ccgcggccgc cgcggcaccc gcgaagaaac cctggaaaaa 60
tggattaccg cgcgcaaaaa agcggaagaa ctggaaaaag atctgcgcaa aacccgcaaa 120
accattaaaa aactggaaga agaaaacccg tggctgggca acattgtggg cattattcgc 180
aaaggcaaag atggcgaagg cgcgccgccg gcgaaacgcc cgcgcaccga tcagatggaa 240
gtggatagcg gcccgggcaa acgcccgcat aaaagcggct ttaccgataa agaacgcgaa 300
gatcatcgcc gccgcaaagc gctggaaaac aaaaaaaaac agctgagcgc gggcggcaaa 360
attctgagca aagaagaaga agaagaactg cgccgcctga ccgatgaaga tgaagaacgc 420
aaacgccgcg tggcgggccc gcgcgtgggc gatgtgaacc cgagccgcgg cggcccgcgc 480
ggcgcgccgg gcggcggctt tgtgccgcag atggcgggcg tgccggaaag cccgtttagc 540
cgcaccggcg aaggcctgga tattcgcggc acccagggct ttccgtgggt gagcccgagc 600
ccgccgcagc agcgcctgcc gctgctggaa tgcaccccgc ag                    642

<210> 9
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> HDAg gentotype 2 B (wt)

<400> 9
agccagagcg aaagcaaaaa aaaccgccgc ggcggccgcg aagatattct ggaaaaatgg 60
attaccaccc gccgcaaagc ggaagaactg gaaaaagatc tgcgcaaagc gcgcaaaacc 120
attaaaaaac tggaagatga aaacccgtgg ctgggcaaca ttattggcat tattcgcaaa 180
ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaaatt 240
gatagcggca ccggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat 300
catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcagcgg cggcaaaaac 360
ctgagccgcg aagaagaaga agaactgggc cgcctgaccg tggaagatga agaacgccgc 420
cgccgcgtgg cgggcccgcg caccggcgat gtgaacctga gcggcggcgg cccgcgcggc 480
gcgccgggcg gcggctttgt gccgcgcatg gaaggcgtgc cggaaagccc gtttacccgc 540
accggcgaag gcctggatat tcgcggcaac cagggctttc cgtgggtgcg cccgagcccg 600
ccgcagcagc gcctgccgct gctggaatgc accccgcag                        639

<210> 10
<211> 3189
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 1 wt

<400> 10
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcaga gccgcagcga aagcaaaaaa 660
aaccgcggcg gccgcgaaga agtgctggaa cagtgggtga acggccgcaa aaaactggaa 720
gaactggaac gcgaactgcg ccgcgcgcgc aaaaaaatta aaaaactgga agatgataac 780
ccgtggctgg gcaacgtgaa aggcattctg ggcaaaaaag ataaagatgg cgaaggcgcg 840
ccgccggcga aacgcgcgcg caccgatcag atggaaattg atagcggccc gcgcaaacgc 900
ccgctgcgcg gcggctttac cgatcgcgaa cgccaggatc atcgccgccg caaagcgctg 960
aaaaacaaaa aaaaacagct gagcgcgggc ggcaaaagcc tgagcaaaga agaagaagaa 1020
gaactgaaac gcctgacccg cgaagatgaa gaacgcaaaa aagaagaaca tggcccgagc 1080
cgcctgggcg tgaacccgag cgaaggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgagcatgc agggcattcc ggaaagccgc tttacccgca ccggcgaagg cctggatgtg 1200
cgcggcagcc gcggctttcc gcaggatatt ctgtttccga gcgatccgcc gtttagcccg 1260
cagagctgcc gcccgcaggg caccaacctg agcaccagca acccgctggg cttttttccg 1320
gatcatcagc tggatccggc gtttcgcgcg aacagcgcga acccggattg ggattttaac 1380
ccgaacaaag atacctggcc ggatgcgaac aaagtgggcg gccagaacct gagcaccagc 1440
aacccgctgg gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacaccgcg 1500
aacccggatt gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc 1560
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct 1620
ggacctatga gccagagcga aacccgccgc ggccgccgcg gcacccgcga agaaaccctg 1680
gaaaaatgga ttaccgcgcg caaaaaagcg gaagaactgg aaaaagatct gcgcaaaacc 1740
cgcaaaacca ttaaaaaact ggaagaagaa aacccgtggc tgggcaacat tgtgggcatt 1800
attcgcaaag gcaaagatgg cgaaggcgcg ccgccggcga aacgcccgcg caccgatcag 1860
atggaagtgg atagcggccc gggcaaacgc ccgcataaaa gcggctttac cgataaagaa 1920
cgcgaagatc atcgccgccg caaagcgctg gaaaacaaaa aaaaacagct gagcgcgggc 1980
ggcaaaattc tgagcaaaga agaagaagaa gaactgcgcc gcctgaccga tgaagatgaa 2040
gaacgcaaac gccgcgtggc gggcccgcgc gtgggcgatg tgaacccgag ccgcggcggc 2100
ccgcgcggcg cgccgggcgg cggctttgtg ccgcagatgg cgggcgtgcc ggaaagcccg 2160
tttagccgca ccggcgaagg cctggatatt cgcggcaccc agggctttcc gtgggtgagc 2220
ccgagcccgc cgcagcagcg cctgccgctg ctggaatgca ccccgcagag ccagagcgaa 2280
agcaaaaaaa accgccgcgg cggccgcgaa gatattctgg aaaaatggat taccacccgc 2340
cgcaaagcgg aagaactgga aaaagatctg cgcaaagcgc gcaaaaccat taaaaaactg 2400
gaagatgaaa acccgtggct gggcaacatt attggcatta ttcgcaaagg caaagatggc 2460
gaaggcgcgc cgccggcgaa acgcccgcgc accgatcaga tggaaattga tagcggcacc 2520
ggcaaacgcc cgcataaaag cggctttacc gataaagaac gcgaagatca tcgccgccgc 2580
aaagcgctgg aaaacaaaaa aaaacagctg agcagcggcg gcaaaaacct gagccgcgaa 2640
gaagaagaag aactgggccg cctgaccgtg gaagatgaag aacgccgccg ccgcgtggcg 2700
ggcccgcgca ccggcgatgt gaacctgagc ggcggcggcc cgcgcggcgc gccgggcggc 2760
ggctttgtgc cgcgcatgga aggcgtgccg gaaagcccgt ttacccgcac cggcgaaggc 2820
ctggatattc gcggcaacca gggctttccg tgggtgcgcc cgagcccgcc gcagcagcgc 2880
ctgccgctgc tggaatgcac cccgcagggc accaacctga gcaccagcaa cccgctgggc 2940
ttttttccgg atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg 3000
gattttaacc cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg 3060
agcaccagca acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg 3120
aacaccgcga acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac 3180
aaagtgggc                                                         3189

<210> 11
<211> 3221
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta1 wt with restriction sites (HindIII/ EcoRI)

<400> 11
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagagcc 660
gcagcgaaag caaaaaaaac cgcggcggcc gcgaagaagt gctggaacag tgggtgaacg 720
gccgcaaaaa actggaagaa ctggaacgcg aactgcgccg cgcgcgcaaa aaaattaaaa 780
aactggaaga tgataacccg tggctgggca acgtgaaagg cattctgggc aaaaaagata 840
aagatggcga aggcgcgccg ccggcgaaac gcgcgcgcac cgatcagatg gaaattgata 900
gcggcccgcg caaacgcccg ctgcgcggcg gctttaccga tcgcgaacgc caggatcatc 960
gccgccgcaa agcgctgaaa aacaaaaaaa aacagctgag cgcgggcggc aaaagcctga 1020
gcaaagaaga agaagaagaa ctgaaacgcc tgacccgcga agatgaagaa cgcaaaaaag 1080
aagaacatgg cccgagccgc ctgggcgtga acccgagcga aggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg agcatgcagg gcattccgga aagccgcttt acccgcaccg 1200
gcgaaggcct ggatgtgcgc ggcagccgcg gctttccgca ggatattctg tttccgagcg 1260
atccgccgtt tagcccgcag agctgccgcc cgcagggcac caacctgagc accagcaacc 1320
cgctgggctt ttttccggat catcagctgg atccggcgtt tcgcgcgaac agcgcgaacc 1380
cggattggga ttttaacccg aacaaagata cctggccgga tgcgaacaaa gtgggcggcc 1440
agaacctgag caccagcaac ccgctgggct tttttccgga tcatcagctg gatccggcgt 1500
ttcgcgcgaa caccgcgaac ccggattggg attttaaccc gaacaaagat acctggccgg 1560
atgcgaacaa agtgggcgga agcggagcta ctaacttcag cctgctgaag caggctggag 1620
acgtggagga gaaccctgga cctatgagcc agagcgaaac ccgccgcggc cgccgcggca 1680
cccgcgaaga aaccctggaa aaatggatta ccgcgcgcaa aaaagcggaa gaactggaaa 1740
aagatctgcg caaaacccgc aaaaccatta aaaaactgga agaagaaaac ccgtggctgg 1800
gcaacattgt gggcattatt cgcaaaggca aagatggcga aggcgcgccg ccggcgaaac 1860
gcccgcgcac cgatcagatg gaagtggata gcggcccggg caaacgcccg cataaaagcg 1920
gctttaccga taaagaacgc gaagatcatc gccgccgcaa agcgctggaa aacaaaaaaa 1980
aacagctgag cgcgggcggc aaaattctga gcaaagaaga agaagaagaa ctgcgccgcc 2040
tgaccgatga agatgaagaa cgcaaacgcc gcgtggcggg cccgcgcgtg ggcgatgtga 2100
acccgagccg cggcggcccg cgcggcgcgc cgggcggcgg ctttgtgccg cagatggcgg 2160
gcgtgccgga aagcccgttt agccgcaccg gcgaaggcct ggatattcgc ggcacccagg 2220
gctttccgtg ggtgagcccg agcccgccgc agcagcgcct gccgctgctg gaatgcaccc 2280
cgcagagcca gagcgaaagc aaaaaaaacc gccgcggcgg ccgcgaagat attctggaaa 2340
aatggattac cacccgccgc aaagcggaag aactggaaaa agatctgcgc aaagcgcgca 2400
aaaccattaa aaaactggaa gatgaaaacc cgtggctggg caacattatt ggcattattc 2460
gcaaaggcaa agatggcgaa ggcgcgccgc cggcgaaacg cccgcgcacc gatcagatgg 2520
aaattgatag cggcaccggc aaacgcccgc ataaaagcgg ctttaccgat aaagaacgcg 2580
aagatcatcg ccgccgcaaa gcgctggaaa acaaaaaaaa acagctgagc agcggcggca 2640
aaaacctgag ccgcgaagaa gaagaagaac tgggccgcct gaccgtggaa gatgaagaac 2700
gccgccgccg cgtggcgggc ccgcgcaccg gcgatgtgaa cctgagcggc ggcggcccgc 2760
gcggcgcgcc gggcggcggc tttgtgccgc gcatggaagg cgtgccggaa agcccgttta 2820
cccgcaccgg cgaaggcctg gatattcgcg gcaaccaggg ctttccgtgg gtgcgcccga 2880
gcccgccgca gcagcgcctg ccgctgctgg aatgcacccc gcagggcacc aacctgagca 2940
ccagcaaccc gctgggcttt tttccggatc atcagctgga tccggcgttt cgcgcgaaca 3000
gcgcgaaccc ggattgggat tttaacccga acaaagatac ctggccggat gcgaacaaag 3060
tgggcggcca gaacctgagc accagcaacc cgctgggctt ttttccggat catcagctgg 3120
atccggcgtt tcgcgcgaac accgcgaacc cggattggga ttttaacccg aacaaagata 3180
cctggccgga tgcgaacaaa gtgggctgat gagaattccg t                     3221

<210> 12
<211> 3192
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized delta 1

<400> 12
gccagcagaa gtgaatcaaa aaagaatcgg ggagggcggg aagaaatcct ggaacagtgg 60
gtcggagcac ggaagaaact ggaagaactg gagagggacc tgcgcaagat caagaagaag 120
atcaagaagc tggaggagga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggatcggg agggagaggg agcaccacct gcaaagaggg ccagagccga ccagatggag 240
gtggatagcg gaccaaggaa gcgccctttc agaggagagt ttaccgacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagaggaagc agctgagctc cggcggcaag 360
tccctgtcta aggaggagga ggaggagctg cgcaagctga cagaggagga cgagagaagg 420
gagaggaggg tggcaggacc tagggtggga ggcgtgaacc cactggaggg aggaaccaga 480
ggagcacctg gaggaggatt cgtgccatcc atgcagggag tgcccgagtc tccttttgcc 540
cggacaggcg agggcctgga tgtgagaggc aatcagggct tcccctggga catcctgttt 600
cctgccgatc cacccttctc tcctcagagc tgccggccac agagcagatc cgagtctaag 660
aagaacaggg gaggaagaga ggaggtgctg gagcagtggg tgaatggccg gaagaagctg 720
gaggagctgg agcgggagct gagaagggcc agaaagaaga tcaagaagct ggaagacgat 780
aatccttggc tgggcaatgt gaaaggcatc ctgggcaaga aggacaagga tggagaggga 840
gcacctccag caaagagggc aagaaccgac cagatggaga tcgattctgg accaaggaag 900
cgccccctga gaggaggctt cacagaccgg gagagacagg atcaccgccg gagaaaggcc 960
ctgaagaaca agaagaagca gctgtccgcc ggaggcaaga gcctgtccaa agaagaggaa 1020
gaggagctga agaggctgac ccgcgaggac gaggagagga agaaggagga gcacggacca 1080
agcaggctgg gagtgaatcc ttccgaggga ggacctaggg gagcaccagg aggaggcttc 1140
gtgccatcta tgcagggcat ccccgagagc cggtttacca gaacaggaga gggcctggac 1200
gtgaggggct cccgcggctt tcctcaggac atcctgttcc catctgatcc ccctttttcc 1260
ccccagtctt gtaggcctca gggcaccaac ctgtctacaa gcaatccact gggcttcttt 1320
cccgaccacc agctggatcc tgccttccgc gccaacagcg ccaatcccga ctgggacttc 1380
aacccaaata aggacacctg gccagatgcc aacaaggtcg gcggccagaa cctgtccaca 1440
tctaatcctc tgggcttctt tccagaccac cagctggatc cagccttccg ggccaacaca 1500
gctaaccctg actgggactt caaccccaat aaggatactt ggcccgacgc caacaaggtc 1560
ggcggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac 1620
cctggaccta tgagccagtc cgagacaagg aggggccgga gaggaaccag ggaggagaca 1680
ctggagaagt ggatcacagc ccgcaagaag gccgaggagc tggagaagga cctgcggaag 1740
accagaaaga caatcaagaa gctggaagaa gagaacccat ggctgggcaa tatcgtgggc 1800
atcatcagaa agggcaagga cggcgaggga gcaccaccag caaagaggcc caggactgat 1860
cagatggaag tcgatagcgg accaggcaag cggcctcaca agtccggctt cacagacaag 1920
gagagagagg accataggcg ccggaaggcc ctggaaaaca agaagaagca attatccgcc 1980
ggcggcaaga tcctgtccaa agaggaagaa gaggagctga gaaggctgac cgacgaggat 2040
gaggagagga aaagaagggt ggcaggacca agggtgggcg acgtgaatcc cagcagggga 2100
ggaccaagag gcgcccctgg cggcggcttc gtgccacaga tggcaggagt gccagagagc 2160
cccttttcca ggacaggaga gggcctggat atcagaggca cccagggctt tccttgggtg 2220
tctccaagcc ctccacagca gcggctgcca ctgctggagt gcacccctca gtcccagtct 2280
gagagcaaga agaacagaag gggcggcaga gaggacatcc tggagaagtg gatcaccaca 2340
cgcagaaaag ctgaagaact ggaaaaggac ctgaggaagg cccgcaaaac aatcaagaag 2400
ctggaggatg aaaatccatg gctgggaaac atcatcggca tcatcaggaa gggcaaggac 2460
ggggaaggcg caccacctgc aaagcggcct agaacagatc agatggaaat cgattctggc 2520
accggcaaga ggccacacaa gagcggcttc accgacaagg agcgcgagga tcacagaagg 2580
cgcaaggccc tggagaacaa gaagaagcaa ttaagcagcg gcggcaagaa tctgtccaga 2640
gaagaagagg aggagctggg ccgcctgacc gtggaggacg aggagcggag aaggcgcgtg 2700
gcaggaccac gcacaggcga tgtgaacctg tccggaggag gaccaagggg agcacctgga 2760
ggcggcttcg tgcctagaat ggagggagtg cctgagtccc ccttcacccg caccggagag 2820
ggcctggaca tcagaggcaa tcagggattc ccatgggtga ggcccagccc accacagcag 2880
cgcctgccac tgctggagtg taccccccag ggcacaaacc tgtccacctc taatcccctg 2940
ggcttctttc ctgatcatca gctggaccca gccttcaggg ccaactccgc caatccagat 3000
tgggacttca acccgaataa ggatacttgg ccagatgcaa acaaggtcgg aggacagaac 3060
ctgagcacat ccaaccctct gggcttcttt cctgaccatc agctggatcc cgcctttcgc 3120
gccaataccg ccaaccctga ttgggacttc aaccctaata aggatacttg gcctgatgct 3180
aataaggtcg gg                                                     3192

<210> 13
<211> 3221
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 1 optimized with restriction sites (HindIII
      and EcoRI)

<400> 13
aagcttgcac catggccagc agaagtgaat caaaaaagaa tcggggaggg cgggaagaaa 60
tcctggaaca gtgggtcgga gcacggaaga aactggaaga actggagagg gacctgcgca 120
agatcaagaa gaagatcaag aagctggagg aggagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat cgggagggag agggagcacc acctgcaaag agggccagag 240
ccgaccagat ggaggtggat agcggaccaa ggaagcgccc tttcagagga gagtttaccg 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagagg aagcagctga 360
gctccggcgg caagtccctg tctaaggagg aggaggagga gctgcgcaag ctgacagagg 420
aggacgagag aagggagagg agggtggcag gacctagggt gggaggcgtg aacccactgg 480
agggaggaac cagaggagca cctggaggag gattcgtgcc atccatgcag ggagtgcccg 540
agtctccttt tgcccggaca ggcgagggcc tggatgtgag aggcaatcag ggcttcccct 600
gggacatcct gtttcctgcc gatccaccct tctctcctca gagctgccgg ccacagagca 660
gatccgagtc taagaagaac aggggaggaa gagaggaggt gctggagcag tgggtgaatg 720
gccggaagaa gctggaggag ctggagcggg agctgagaag ggccagaaag aagatcaaga 780
agctggaaga cgataatcct tggctgggca atgtgaaagg catcctgggc aagaaggaca 840
aggatggaga gggagcacct ccagcaaaga gggcaagaac cgaccagatg gagatcgatt 900
ctggaccaag gaagcgcccc ctgagaggag gcttcacaga ccgggagaga caggatcacc 960
gccggagaaa ggccctgaag aacaagaaga agcagctgtc cgccggaggc aagagcctgt 1020
ccaaagaaga ggaagaggag ctgaagaggc tgacccgcga ggacgaggag aggaagaagg 1080
aggagcacgg accaagcagg ctgggagtga atccttccga gggaggacct aggggagcac 1140
caggaggagg cttcgtgcca tctatgcagg gcatccccga gagccggttt accagaacag 1200
gagagggcct ggacgtgagg ggctcccgcg gctttcctca ggacatcctg ttcccatctg 1260
atcccccttt ttccccccag tcttgtaggc ctcagggcac caacctgtct acaagcaatc 1320
cactgggctt ctttcccgac caccagctgg atcctgcctt ccgcgccaac agcgccaatc 1380
ccgactggga cttcaaccca aataaggaca cctggccaga tgccaacaag gtcggcggcc 1440
agaacctgtc cacatctaat cctctgggct tctttccaga ccaccagctg gatccagcct 1500
tccgggccaa cacagctaac cctgactggg acttcaaccc caataaggat acttggcccg 1560
acgccaacaa ggtcggcgga agcggagcta ctaacttcag cctgctgaag caggctggag 1620
acgtggagga gaaccctgga cctatgagcc agtccgagac aaggaggggc cggagaggaa 1680
ccagggagga gacactggag aagtggatca cagcccgcaa gaaggccgag gagctggaga 1740
aggacctgcg gaagaccaga aagacaatca agaagctgga agaagagaac ccatggctgg 1800
gcaatatcgt gggcatcatc agaaagggca aggacggcga gggagcacca ccagcaaaga 1860
ggcccaggac tgatcagatg gaagtcgata gcggaccagg caagcggcct cacaagtccg 1920
gcttcacaga caaggagaga gaggaccata ggcgccggaa ggccctggaa aacaagaaga 1980
agcaattatc cgccggcggc aagatcctgt ccaaagagga agaagaggag ctgagaaggc 2040
tgaccgacga ggatgaggag aggaaaagaa gggtggcagg accaagggtg ggcgacgtga 2100
atcccagcag gggaggacca agaggcgccc ctggcggcgg cttcgtgcca cagatggcag 2160
gagtgccaga gagccccttt tccaggacag gagagggcct ggatatcaga ggcacccagg 2220
gctttccttg ggtgtctcca agccctccac agcagcggct gccactgctg gagtgcaccc 2280
ctcagtccca gtctgagagc aagaagaaca gaaggggcgg cagagaggac atcctggaga 2340
agtggatcac cacacgcaga aaagctgaag aactggaaaa ggacctgagg aaggcccgca 2400
aaacaatcaa gaagctggag gatgaaaatc catggctggg aaacatcatc ggcatcatca 2460
ggaagggcaa ggacggggaa ggcgcaccac ctgcaaagcg gcctagaaca gatcagatgg 2520
aaatcgattc tggcaccggc aagaggccac acaagagcgg cttcaccgac aaggagcgcg 2580
aggatcacag aaggcgcaag gccctggaga acaagaagaa gcaattaagc agcggcggca 2640
agaatctgtc cagagaagaa gaggaggagc tgggccgcct gaccgtggag gacgaggagc 2700
ggagaaggcg cgtggcagga ccacgcacag gcgatgtgaa cctgtccgga ggaggaccaa 2760
ggggagcacc tggaggcggc ttcgtgccta gaatggaggg agtgcctgag tcccccttca 2820
cccgcaccgg agagggcctg gacatcagag gcaatcaggg attcccatgg gtgaggccca 2880
gcccaccaca gcagcgcctg ccactgctgg agtgtacccc ccagggcaca aacctgtcca 2940
cctctaatcc cctgggcttc tttcctgatc atcagctgga cccagccttc agggccaact 3000
ccgccaatcc agattgggac ttcaacccga ataaggatac ttggccagat gcaaacaagg 3060
tcggaggaca gaacctgagc acatccaacc ctctgggctt ctttcctgac catcagctgg 3120
atcccgcctt tcgcgccaat accgccaacc ctgattggga cttcaaccct aataaggata 3180
cttggcctga tgctaataag gtcgggtgat gagaattccg t                     3221

<210> 14
<211> 1065
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 1 protein

<400> 14
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys
225                 230                 235                 240 
Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys
                245                 250                 255     
Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu
            260                 265                 270         
Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu
    290                 295                 300                 
Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu
                325                 330                 335     
Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu
            340                 345                 350         
Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro
        355                 360                 365             
Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser
    370                 375                 380                 
Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser
                405                 410                 415     
Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu
            420                 425                 430         
Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro
        435                 440                 445             
Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn
    450                 455                 460                 
Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser
465                 470                 475                 480 
Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala
                485                 490                 495     
Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys
            500                 505                 510         
Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn
        515                 520                 525             
Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro
    530                 535                 540                 
Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu
545                 550                 555                 560 
Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu
                565                 570                 575     
Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu
            580                 585                 590         
Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp
        595                 600                 605             
Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu
    610                 615                 620                 
Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp
625                 630                 635                 640 
Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys
                645                 650                 655     
Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu
            660                 665                 670         
Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val
        675                 680                 685             
Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg
    690                 695                 700                 
Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu
705                 710                 715                 720 
Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln
                725                 730                 735     
Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu
            740                 745                 750         
Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg
        755                 760                 765             
Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys
    770                 775                 780                 
Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys
785                 790                 795                 800 
Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile
                805                 810                 815     
Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg
            820                 825                 830         
Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys
        835                 840                 845             
Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala
    850                 855                 860                 
Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser
865                 870                 875                 880 
Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu
                885                 890                 895     
Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser
            900                 905                 910         
Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met
        915                 920                 925             
Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp
    930                 935                 940                 
Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln
945                 950                 955                 960 
Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser
                965                 970                 975     
Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala
            980                 985                 990         
Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys
        995                 1000                1005            
Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr
    1010                1015                1020                
Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe
1025                1030                1035               1040 
Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp
                1045                1050                1055    
Thr Trp Pro Asp Ala Asn Lys Val Gly
            1060                1065


<210> 15
<211> 3189
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 2 sequence wt

<400> 15
ggcaccaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 60
gcgtttcgcg cgaacagcgc gaacccggat tgggatttta acccgaacaa agatacctgg 120
ccggatgcga acaaagtggg cggccagaac ctgagcacca gcaacccgct gggctttttt 180
ccggatcatc agctggatcc ggcgtttcgc gcgaacaccg cgaacccgga ttgggatttt 240
aacccgaaca aagatacctg gccggatgcg aacaaagtgg gcagccgcag cgaaagcaaa 300
aaaaaccgcg gcggccgcga agaaattctg gaacagtggg tgggcgcgcg caaaaaactg 360
gaagaactgg aacgcgatct gcgcaaaatt aaaaaaaaaa ttaaaaaact ggaagaagaa 420
aacccgtggc tgggcaacat taaaggcatt ctgggcaaaa aagatcgcga aggcgaaggc 480
gcgccgccgg cgaaacgcgc gcgcgcggat cagatggaag tggatagcgg cccgcgcaaa 540
cgcccgtttc gcggcgaatt taccgataaa gaacgccgcg atcatcgccg ccgcaaagcg 600
ctggaaaaca aacgcaaaca gctgagcagc ggcggcaaaa gcctgagcaa agaagaagaa 660
gaagaactgc gcaaactgac cgaagaagat gaacgccgcg aacgccgcgt ggcgggcccg 720
cgcgtgggcg gcgtgaaccc gctggaaggc ggcacccgcg gcgcgccggg cggcggcttt 780
gtgccgagca tgcagggcgt gccggaaagc ccgtttgcgc gcaccggcga aggcctggat 840
gtgcgcggca accagggctt tccgtgggat attctgtttc cggcggatcc gccgtttagc 900
ccgcagagct gccgcccgca gagccgcagc gaaagcaaaa aaaaccgcgg cggccgcgaa 960
gaagtgctgg aacagtgggt gaacggccgc aaaaaactgg aagaactgga acgcgaactg 1020
cgccgcgcgc gcaaaaaaat taaaaaactg gaagatgata acccgtggct gggcaacgtg 1080
aaaggcattc tgggcaaaaa agataaagat ggcgaaggcg cgccgccggc gaaacgcgcg 1140
cgcaccgatc agatggaaat tgatagcggc ccgcgcaaac gcccgctgcg cggcggcttt 1200
accgatcgcg aacgccagga tcatcgccgc cgcaaagcgc tgaaaaacaa aaaaaaacag 1260
ctgagcgcgg gcggcaaaag cctgagcaaa gaagaagaag aagaactgaa acgcctgacc 1320
cgcgaagatg aagaacgcaa aaaagaagaa catggcccga gccgcctggg cgtgaacccg 1380
agcgaaggcg gcccgcgcgg cgcgccgggc ggcggctttg tgccgagcat gcagggcatt 1440
ccggaaagcc gctttacccg caccggcgaa ggcctggatg tgcgcggcag ccgcggcttt 1500
ccgcaggata ttctgtttcc gagcgatccg ccgtttagcc cgcagagctg ccgcccgcag 1560
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct 1620
ggacctatgg gcaccaacct gagcaccagc aacccgctgg gcttttttcc ggatcatcag 1680
ctggatccgg cgtttcgcgc gaacagcgcg aacccggatt gggattttaa cccgaacaaa 1740
gatacctggc cggatgcgaa caaagtgggc ggccagaacc tgagcaccag caacccgctg 1800
ggcttttttc cggatcatca gctggatccg gcgtttcgcg cgaacaccgc gaacccggat 1860
tgggatttta acccgaacaa agatacctgg ccggatgcga acaaagtggg cagccagagc 1920
gaaacccgcc gcggccgccg cggcacccgc gaagaaaccc tggaaaaatg gattaccgcg 1980
cgcaaaaaag cggaagaact ggaaaaagat ctgcgcaaaa cccgcaaaac cattaaaaaa 2040
ctggaagaag aaaacccgtg gctgggcaac attgtgggca ttattcgcaa aggcaaagat 2100
ggcgaaggcg cgccgccggc gaaacgcccg cgcaccgatc agatggaagt ggatagcggc 2160
ccgggcaaac gcccgcataa aagcggcttt accgataaag aacgcgaaga tcatcgccgc 2220
cgcaaagcgc tggaaaacaa aaaaaaacag ctgagcgcgg gcggcaaaat tctgagcaaa 2280
gaagaagaag aagaactgcg ccgcctgacc gatgaagatg aagaacgcaa acgccgcgtg 2340
gcgggcccgc gcgtgggcga tgtgaacccg agccgcggcg gcccgcgcgg cgcgccgggc 2400
ggcggctttg tgccgcagat ggcgggcgtg ccggaaagcc cgtttagccg caccggcgaa 2460
ggcctggata ttcgcggcac ccagggcttt ccgtgggtga gcccgagccc gccgcagcag 2520
cgcctgccgc tgctggaatg caccccgcag agccagagcg aaagcaaaaa aaaccgccgc 2580
ggcggccgcg aagatattct ggaaaaatgg attaccaccc gccgcaaagc ggaagaactg 2640
gaaaaagatc tgcgcaaagc gcgcaaaacc attaaaaaac tggaagatga aaacccgtgg 2700
ctgggcaaca ttattggcat tattcgcaaa ggcaaagatg gcgaaggcgc gccgccggcg 2760
aaacgcccgc gcaccgatca gatggaaatt gatagcggca ccggcaaacg cccgcataaa 2820
agcggcttta ccgataaaga acgcgaagat catcgccgcc gcaaagcgct ggaaaacaaa 2880
aaaaaacagc tgagcagcgg cggcaaaaac ctgagccgcg aagaagaaga agaactgggc 2940
cgcctgaccg tggaagatga agaacgccgc cgccgcgtgg cgggcccgcg caccggcgat 3000
gtgaacctga gcggcggcgg cccgcgcggc gcgccgggcg gcggctttgt gccgcgcatg 3060
gaaggcgtgc cggaaagccc gtttacccgc accggcgaag gcctggatat tcgcggcaac 3120
cagggctttc cgtgggtgcg cccgagcccg ccgcagcagc gcctgccgct gctggaatgc 3180
accccgcag                                                         3189

<210> 16
<211> 3221
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 2 wt with restriction sites (HindIII /EcoRI)

<400> 16
aagcttgcac catggccggc accaacctga gcaccagcaa cccgctgggc ttttttccgg 60
atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc 120
cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca 180
acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga 240
acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggca 300
gccgcagcga aagcaaaaaa aaccgcggcg gccgcgaaga aattctggaa cagtgggtgg 360
gcgcgcgcaa aaaactggaa gaactggaac gcgatctgcg caaaattaaa aaaaaaatta 420
aaaaactgga agaagaaaac ccgtggctgg gcaacattaa aggcattctg ggcaaaaaag 480
atcgcgaagg cgaaggcgcg ccgccggcga aacgcgcgcg cgcggatcag atggaagtgg 540
atagcggccc gcgcaaacgc ccgtttcgcg gcgaatttac cgataaagaa cgccgcgatc 600
atcgccgccg caaagcgctg gaaaacaaac gcaaacagct gagcagcggc ggcaaaagcc 660
tgagcaaaga agaagaagaa gaactgcgca aactgaccga agaagatgaa cgccgcgaac 720
gccgcgtggc gggcccgcgc gtgggcggcg tgaacccgct ggaaggcggc acccgcggcg 780
cgccgggcgg cggctttgtg ccgagcatgc agggcgtgcc ggaaagcccg tttgcgcgca 840
ccggcgaagg cctggatgtg cgcggcaacc agggctttcc gtgggatatt ctgtttccgg 900
cggatccgcc gtttagcccg cagagctgcc gcccgcagag ccgcagcgaa agcaaaaaaa 960
accgcggcgg ccgcgaagaa gtgctggaac agtgggtgaa cggccgcaaa aaactggaag 1020
aactggaacg cgaactgcgc cgcgcgcgca aaaaaattaa aaaactggaa gatgataacc 1080
cgtggctggg caacgtgaaa ggcattctgg gcaaaaaaga taaagatggc gaaggcgcgc 1140
cgccggcgaa acgcgcgcgc accgatcaga tggaaattga tagcggcccg cgcaaacgcc 1200
cgctgcgcgg cggctttacc gatcgcgaac gccaggatca tcgccgccgc aaagcgctga 1260
aaaacaaaaa aaaacagctg agcgcgggcg gcaaaagcct gagcaaagaa gaagaagaag 1320
aactgaaacg cctgacccgc gaagatgaag aacgcaaaaa agaagaacat ggcccgagcc 1380
gcctgggcgt gaacccgagc gaaggcggcc cgcgcggcgc gccgggcggc ggctttgtgc 1440
cgagcatgca gggcattccg gaaagccgct ttacccgcac cggcgaaggc ctggatgtgc 1500
gcggcagccg cggctttccg caggatattc tgtttccgag cgatccgccg tttagcccgc 1560
agagctgccg cccgcaggga agcggagcta ctaacttcag cctgctgaag caggctggag 1620
acgtggagga gaaccctgga cctatgggca ccaacctgag caccagcaac ccgctgggct 1680
tttttccgga tcatcagctg gatccggcgt ttcgcgcgaa cagcgcgaac ccggattggg 1740
attttaaccc gaacaaagat acctggccgg atgcgaacaa agtgggcggc cagaacctga 1800
gcaccagcaa cccgctgggc ttttttccgg atcatcagct ggatccggcg tttcgcgcga 1860
acaccgcgaa cccggattgg gattttaacc cgaacaaaga tacctggccg gatgcgaaca 1920
aagtgggcag ccagagcgaa acccgccgcg gccgccgcgg cacccgcgaa gaaaccctgg 1980
aaaaatggat taccgcgcgc aaaaaagcgg aagaactgga aaaagatctg cgcaaaaccc 2040
gcaaaaccat taaaaaactg gaagaagaaa acccgtggct gggcaacatt gtgggcatta 2100
ttcgcaaagg caaagatggc gaaggcgcgc cgccggcgaa acgcccgcgc accgatcaga 2160
tggaagtgga tagcggcccg ggcaaacgcc cgcataaaag cggctttacc gataaagaac 2220
gcgaagatca tcgccgccgc aaagcgctgg aaaacaaaaa aaaacagctg agcgcgggcg 2280
gcaaaattct gagcaaagaa gaagaagaag aactgcgccg cctgaccgat gaagatgaag 2340
aacgcaaacg ccgcgtggcg ggcccgcgcg tgggcgatgt gaacccgagc cgcggcggcc 2400
cgcgcggcgc gccgggcggc ggctttgtgc cgcagatggc gggcgtgccg gaaagcccgt 2460
ttagccgcac cggcgaaggc ctggatattc gcggcaccca gggctttccg tgggtgagcc 2520
cgagcccgcc gcagcagcgc ctgccgctgc tggaatgcac cccgcagagc cagagcgaaa 2580
gcaaaaaaaa ccgccgcggc ggccgcgaag atattctgga aaaatggatt accacccgcc 2640
gcaaagcgga agaactggaa aaagatctgc gcaaagcgcg caaaaccatt aaaaaactgg 2700
aagatgaaaa cccgtggctg ggcaacatta ttggcattat tcgcaaaggc aaagatggcg 2760
aaggcgcgcc gccggcgaaa cgcccgcgca ccgatcagat ggaaattgat agcggcaccg 2820
gcaaacgccc gcataaaagc ggctttaccg ataaagaacg cgaagatcat cgccgccgca 2880
aagcgctgga aaacaaaaaa aaacagctga gcagcggcgg caaaaacctg agccgcgaag 2940
aagaagaaga actgggccgc ctgaccgtgg aagatgaaga acgccgccgc cgcgtggcgg 3000
gcccgcgcac cggcgatgtg aacctgagcg gcggcggccc gcgcggcgcg ccgggcggcg 3060
gctttgtgcc gcgcatggaa ggcgtgccgg aaagcccgtt tacccgcacc ggcgaaggcc 3120
tggatattcg cggcaaccag ggctttccgt gggtgcgccc gagcccgccg cagcagcgcc 3180
tgccgctgct ggaatgcacc ccgcagtgat gagaattccg t                     3221

<210> 17
<211> 3192
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 2 optimized

<400> 17
gccggcacta acctgtctac atcaaaccct ctgggatttt tccccgatca tcagctggac 60
cccgcatttc gcgctaactc tgctaaccct gactgggatt tcaaccctaa taaggacaca 120
tggccagatg ccaacaaggt cggcggccag aacctgtcca cctctaatcc cctgggcttc 180
tttcctgacc accagctgga tcctgccttc agggccaaca ccgccaatcc cgactgggac 240
ttcaacccaa ataaggatac ctggcctgac gctaacaagg tcggcagccg gtccgagtct 300
aagaagaata ggggaggaag ggaggagatc ctggagcagt gggtgggcgc cagaaagaag 360
ctggaggagc tggagcggga cctgagaaag atcaagaaga agatcaagaa gctggaggag 420
gagaacccct ggctgggcaa tatcaagggc atcctgggca agaaggatcg ggagggagag 480
ggagcaccac ctgcaaagag ggccagagcc gaccagatgg aggtggattc cggccctagg 540
aagcgcccat tcagaggcga gtttacagac aaggagcgga gagatcacag gcgccggaag 600
gccctggaga acaagaggaa gcagctgagc tccggcggca agagcctgtc caaggaggag 660
gaggaggagc tgcgcaagct gaccgaggag gacgagagaa gggagaggag ggtggcagga 720
cctagggtgg gaggcgtgaa cccactggag ggaggaacaa gaggagcacc cggaggaggc 780
ttcgtgcctt ctatgcaggg cgtgcctgag agcccatttg ccaggaccgg agagggcctg 840
gacgtgagag gcaatcaggg cttcccatgg gacatcctgt ttcccgccga tccacccttc 900
agcccacagt cctgcaggcc ccagtctcgc agcgagtcca agaagaacag aggcggaagg 960
gaggaggtgc tggagcagtg ggtgaatggc aggaagaagc tggaagaact ggagagggag 1020
ctgagaaggg cccgcaagaa gatcaagaag ctggaagacg ataatccttg gctgggcaat 1080
gtgaaaggca tcctgggcaa gaaggacaag gatggagagg gagcacctcc agcaaagagg 1140
gcaagaacag accagatgga gatcgattcc ggaccaagga agcgccctct gaggggaggc 1200
ttcaccgacc gggagagaca ggatcaccgc cggagaaagg ccctgaagaa caagaagaag 1260
cagctgagcg ccggcggcaa gtctctgagt aaagaagaag aggaggagct gaagcggctg 1320
acaagagagg acgaggagag gaagaaggag gagcacggac catccaggct gggagtgaat 1380
ccttctgagg gaggaccaag gggcgcccct ggcggaggct tcgtgcctag catgcagggc 1440
atcccagagt ccaggtttac caggacaggc gaaggcctgg acgtgcgggg ctctagaggc 1500
tttccccagg acatcctgtt ccctagcgat cccccttttt ctcctcagag ctgtagacca 1560
cagggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac 1620
cctggaccta tgggcaccaa cctgtccaca tctaaccctc tgggcttctt tccagatcat 1680
cagctggacc cagccttcag ggccaacagc gccaatccag actgggactt caaccccaat 1740
aaggacacat ggcctgacgc aaacaaggtc ggaggacaga acctgagcac ctccaatcca 1800
ctgggcttct ttcccgacca ccagctggat ccagccttcc gcgccaacac tgctaaccct 1860
gattgggact tcaaccctaa taaggataca tggcctgatg ccaataaggt cggctctcag 1920
agcgagacaa ggaggggccg gagaggaacc agggaggaga cactggagaa gtggatcacc 1980
gcccgcaaga aggccgagga gctggagaag gacctgagga agacccgcaa gacaatcaag 2040
aagctggaag aagagaaccc atggctgggc aatatcgtgg gcatcatcag aaagggcaag 2100
gacggcgagg gagcaccacc agcaaagagg ccccgcacag atcagatgga agtggattcc 2160
ggacctggca agcggccaca caagtctggc ttcaccgaca aggagagaga ggaccatagg 2220
cgccggaagg ccctggaaaa caagaagaag caattatctg ccggcggcaa gatcctgagt 2280
aaagaagagg aagaggagct gagaaggctg accgacgagg atgaggagag gaagcgccgg 2340
gtggccggcc cacgcgtggg cgacgtgaat ccctccaggg gaggaccaag aggagcacct 2400
ggaggcggct tcgtgcccca gatggccggc gtgcccgagt cccctttttc tcggaccggc 2460
gagggcctgg atatcagagg cacacagggc tttccatggg tgtccccctc tcctccacag 2520
cagaggctgc cactgctgga gtgcacaccc cagagccaga gcgaatctaa gaagaacaga 2580
aggggaggcc gcgaggacat cctggaaaaa tggatcacca cacgcagaaa agctgaagaa 2640
ctggaaaagg acctgcggaa ggccagaaag accatcaaga agctggagga tgaaaatcca 2700
tggctgggaa acatcatcgg catcatccgg aagggcaagg acggggaagg cgcaccacct 2760
gcaaagcggc ctagaaccga tcagatggaa atcgatagcg gcacaggcaa gaggccacac 2820
aagtccggct tcaccgataa agagcgcgag gatcacagaa ggcgcaaggc cctggagaac 2880
aagaagaagc aattaagcag cggcggcaag aatctgtcca gagaagagga ggaagagctg 2940
ggccgcctga cagtggagga cgaggagcgg agaaggcgcg tggcaggacc cagaaccggc 3000
gatgtgaacc tgtccggagg aggacctagg ggagcaccag gaggcggctt cgtgcctaga 3060
atggagggcg tgccagagtc tccctttacc cggacaggcg agggcctgga catcagaggc 3120
aatcagggct ttccctgggt ccgcccctcc ccccctcagc agagactgcc actgctggaa 3180
tgcacaccac ag                                                     3192

<210> 18
<211> 3221
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 2 codon optimized + Restriction sites

<400> 18
aagcttgcac catggccggc actaacctgt ctacatcaaa ccctctggga tttttccccg 60
atcatcagct ggaccccgca tttcgcgcta actctgctaa ccctgactgg gatttcaacc 120
ctaataagga cacatggcca gatgccaaca aggtcggcgg ccagaacctg tccacctcta 180
atcccctggg cttctttcct gaccaccagc tggatcctgc cttcagggcc aacaccgcca 240
atcccgactg ggacttcaac ccaaataagg atacctggcc tgacgctaac aaggtcggca 300
gccggtccga gtctaagaag aataggggag gaagggagga gatcctggag cagtgggtgg 360
gcgccagaaa gaagctggag gagctggagc gggacctgag aaagatcaag aagaagatca 420
agaagctgga ggaggagaac ccctggctgg gcaatatcaa gggcatcctg ggcaagaagg 480
atcgggaggg agagggagca ccacctgcaa agagggccag agccgaccag atggaggtgg 540
attccggccc taggaagcgc ccattcagag gcgagtttac agacaaggag cggagagatc 600
acaggcgccg gaaggccctg gagaacaaga ggaagcagct gagctccggc ggcaagagcc 660
tgtccaagga ggaggaggag gagctgcgca agctgaccga ggaggacgag agaagggaga 720
ggagggtggc aggacctagg gtgggaggcg tgaacccact ggagggagga acaagaggag 780
cacccggagg aggcttcgtg ccttctatgc agggcgtgcc tgagagccca tttgccagga 840
ccggagaggg cctggacgtg agaggcaatc agggcttccc atgggacatc ctgtttcccg 900
ccgatccacc cttcagccca cagtcctgca ggccccagtc tcgcagcgag tccaagaaga 960
acagaggcgg aagggaggag gtgctggagc agtgggtgaa tggcaggaag aagctggaag 1020
aactggagag ggagctgaga agggcccgca agaagatcaa gaagctggaa gacgataatc 1080
cttggctggg caatgtgaaa ggcatcctgg gcaagaagga caaggatgga gagggagcac 1140
ctccagcaaa gagggcaaga acagaccaga tggagatcga ttccggacca aggaagcgcc 1200
ctctgagggg aggcttcacc gaccgggaga gacaggatca ccgccggaga aaggccctga 1260
agaacaagaa gaagcagctg agcgccggcg gcaagtctct gagtaaagaa gaagaggagg 1320
agctgaagcg gctgacaaga gaggacgagg agaggaagaa ggaggagcac ggaccatcca 1380
ggctgggagt gaatccttct gagggaggac caaggggcgc ccctggcgga ggcttcgtgc 1440
ctagcatgca gggcatccca gagtccaggt ttaccaggac aggcgaaggc ctggacgtgc 1500
ggggctctag aggctttccc caggacatcc tgttccctag cgatccccct ttttctcctc 1560
agagctgtag accacaggga agcggagcta ctaacttcag cctgctgaag caggctggag 1620
acgtggagga gaaccctgga cctatgggca ccaacctgtc cacatctaac cctctgggct 1680
tctttccaga tcatcagctg gacccagcct tcagggccaa cagcgccaat ccagactggg 1740
acttcaaccc caataaggac acatggcctg acgcaaacaa ggtcggagga cagaacctga 1800
gcacctccaa tccactgggc ttctttcccg accaccagct ggatccagcc ttccgcgcca 1860
acactgctaa ccctgattgg gacttcaacc ctaataagga tacatggcct gatgccaata 1920
aggtcggctc tcagagcgag acaaggaggg gccggagagg aaccagggag gagacactgg 1980
agaagtggat caccgcccgc aagaaggccg aggagctgga gaaggacctg aggaagaccc 2040
gcaagacaat caagaagctg gaagaagaga acccatggct gggcaatatc gtgggcatca 2100
tcagaaaggg caaggacggc gagggagcac caccagcaaa gaggccccgc acagatcaga 2160
tggaagtgga ttccggacct ggcaagcggc cacacaagtc tggcttcacc gacaaggaga 2220
gagaggacca taggcgccgg aaggccctgg aaaacaagaa gaagcaatta tctgccggcg 2280
gcaagatcct gagtaaagaa gaggaagagg agctgagaag gctgaccgac gaggatgagg 2340
agaggaagcg ccgggtggcc ggcccacgcg tgggcgacgt gaatccctcc aggggaggac 2400
caagaggagc acctggaggc ggcttcgtgc cccagatggc cggcgtgccc gagtcccctt 2460
tttctcggac cggcgagggc ctggatatca gaggcacaca gggctttcca tgggtgtccc 2520
cctctcctcc acagcagagg ctgccactgc tggagtgcac accccagagc cagagcgaat 2580
ctaagaagaa cagaagggga ggccgcgagg acatcctgga aaaatggatc accacacgca 2640
gaaaagctga agaactggaa aaggacctgc ggaaggccag aaagaccatc aagaagctgg 2700
aggatgaaaa tccatggctg ggaaacatca tcggcatcat ccggaagggc aaggacgggg 2760
aaggcgcacc acctgcaaag cggcctagaa ccgatcagat ggaaatcgat agcggcacag 2820
gcaagaggcc acacaagtcc ggcttcaccg ataaagagcg cgaggatcac agaaggcgca 2880
aggccctgga gaacaagaag aagcaattaa gcagcggcgg caagaatctg tccagagaag 2940
aggaggaaga gctgggccgc ctgacagtgg aggacgagga gcggagaagg cgcgtggcag 3000
gacccagaac cggcgatgtg aacctgtccg gaggaggacc taggggagca ccaggaggcg 3060
gcttcgtgcc tagaatggag ggcgtgccag agtctccctt tacccggaca ggcgagggcc 3120
tggacatcag aggcaatcag ggctttccct gggtccgccc ctccccccct cagcagagac 3180
tgccactgct ggaatgcaca ccacagtgat gagaattccg t                     3221

<210> 19
<211> 1065
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 2 protein

<400> 19
Met Ala Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro
 1               5                  10                  15      
Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp
            20                  25                  30          
Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val
        35                  40                  45              
Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp
    50                  55                  60                  
His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp
65                  70                  75                  80  
Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
                85                  90                  95      
Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu
            100                 105                 110         
Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp
        115                 120                 125             
Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro
    130                 135                 140                 
Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly
145                 150                 155                 160 
Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val
                165                 170                 175     
Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys
            180                 185                 190         
Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys
        195                 200                 205             
Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu
    210                 215                 220                 
Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala
225                 230                 235                 240 
Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly
                245                 250                 255     
Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser
            260                 265                 270         
Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly
        275                 280                 285             
Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln
    290                 295                 300                 
Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly
305                 310                 315                 320 
Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu
                325                 330                 335     
Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu
            340                 345                 350         
Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys
        355                 360                 365             
Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr
    370                 375                 380                 
Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly
385                 390                 395                 400 
Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu
                405                 410                 415     
Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys
            420                 425                 430         
Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg
        435                 440                 445             
Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu
    450                 455                 460                 
Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln
465                 470                 475                 480 
Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val
                485                 490                 495     
Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro
            500                 505                 510         
Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala Thr Asn
        515                 520                 525             
Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro
    530                 535                 540                 
Met Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp
545                 550                 555                 560 
His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp
                565                 570                 575     
Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
            580                 585                 590         
Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His
        595                 600                 605             
Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp
    610                 615                 620                 
Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ser
625                 630                 635                 640 
Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu
                645                 650                 655     
Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp
            660                 665                 670         
Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro
        675                 680                 685             
Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu
    690                 695                 700                 
Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp
705                 710                 715                 720 
Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu
                725                 730                 735     
Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln
            740                 745                 750         
Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu
        755                 760                 765             
Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly
    770                 775                 780                 
Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala
785                 790                 795                 800 
Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro
                805                 810                 815     
Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe
            820                 825                 830         
Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu
        835                 840                 845             
Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly
    850                 855                 860                 
Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu
865                 870                 875                 880 
Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu
                885                 890                 895     
Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile Arg Lys
            900                 905                 910         
Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp
        915                 920                 925             
Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys Ser Gly
    930                 935                 940                 
Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu
945                 950                 955                 960 
Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser Arg Glu
                965                 970                 975     
Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu Arg Arg
            980                 985                 990         
Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser Gly Gly
        995                 1000                1005            
Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met Glu Gly
    1010                1015                1020                
Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp Ile Arg
1025                1030                1035               1040 
Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln Gln Arg
                1045                1050                1055    
Leu Pro Leu Leu Glu Cys Thr Pro Gln
            1060                1065


<210> 20
<211> 3753
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 3 wt

<400> 20
ggcaccaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 60
gcgtttcgcg cgaacagcgc gaacccggat tgggatttta acccgaacaa agatacctgg 120
ccggatgcga acaaagtggg cggccagaac ctgagcacca gcaacccgct gggctttttt 180
ccggatcatc agctggatcc ggcgtttcgc gcgaacaccg cgaacccgga ttgggatttt 240
aacccgaaca aagatacctg gccggatgcg aacaaagtgg gcagccgcag cgaaagcaaa 300
aaaaaccgcg gcggccgcga agaaattctg gaacagtggg tgggcgcgcg caaaaaactg 360
gaagaactgg aacgcgatct gcgcaaaatt aaaaaaaaaa ttaaaaaact ggaagaagaa 420
aacccgtggc tgggcaacat taaaggcatt ctgggcaaaa aagatcgcga aggcgaaggc 480
gcgccgccgg cgaaacgcgc gcgcgcggat cagatggaag tggatagcgg cccgcgcaaa 540
cgcccgtttc gcggcgaatt taccgataaa gaacgccgcg atcatcgccg ccgcaaagcg 600
ctggaaaaca aacgcaaaca gctgagcagc ggcggcaaaa gcctgagcaa agaagaagaa 660
gaagaactgc gcaaactgac cgaagaagat gaacgccgcg aacgccgcgt ggcgggcccg 720
cgcgtgggcg gcgtgaaccc gctggaaggc ggcacccgcg gcgcgccggg cggcggcttt 780
gtgccgagca tgcagggcgt gccggaaagc ccgtttgcgc gcaccggcga aggcctggat 840
gtgcgcggca accagggctt tccgtgggat attctgtttc cggcggatcc gccgtttagc 900
ccgcagagct gccgcccgca gagccgcagc gaaagcaaaa aaaaccgcgg cggccgcgaa 960
gaagtgctgg aacagtgggt gaacggccgc aaaaaactgg aagaactgga acgcgaactg 1020
cgccgcgcgc gcaaaaaaat taaaaaactg gaagatgata acccgtggct gggcaacgtg 1080
aaaggcattc tgggcaaaaa agataaagat ggcgaaggcg cgccgccggc gaaacgcgcg 1140
cgcaccgatc agatggaaat tgatagcggc ccgcgcaaac gcccgctgcg cggcggcttt 1200
accgatcgcg aacgccagga tcatcgccgc cgcaaagcgc tgaaaaacaa aaaaaaacag 1260
ctgagcgcgg gcggcaaaag cctgagcaaa gaagaagaag aagaactgaa acgcctgacc 1320
cgcgaagatg aagaacgcaa aaaagaagaa catggcccga gccgcctggg cgtgaacccg 1380
agcgaaggcg gcccgcgcgg cgcgccgggc ggcggctttg tgccgagcat gcagggcatt 1440
ccggaaagcc gctttacccg caccggcgaa ggcctggatg tgcgcggcag ccgcggcttt 1500
ccgcaggata ttctgtttcc gagcgatccg ccgtttagcc cgcagagctg ccgcccgcag 1560
ggcaccaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 1620
gcgtttcgcg cgaacagcgc gaacccggat tgggatttta acccgaacaa agatacctgg 1680
ccggatgcga acaaagtggg cggccagaac ctgagcacca gcaacccgct gggctttttt 1740
ccggatcatc agctggatcc ggcgtttcgc gcgaacaccg cgaacccgga ttgggatttt 1800
aacccgaaca aagatacctg gccggatgcg aacaaagtgg gcggaagcgg agctactaac 1860
ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc ctggacctat gggcaccaac 1920
ctgagcacca gcaacccgct gggctttttt ccggatcatc agctggatcc ggcgtttcgc 1980
gcgaacagcg cgaacccgga ttgggatttt aacccgaaca aagatacctg gccggatgcg 2040
aacaaagtgg gcggccagaa cctgagcacc agcaacccgc tgggcttttt tccggatcat 2100
cagctggatc cggcgtttcg cgcgaacacc gcgaacccgg attgggattt taacccgaac 2160
aaagatacct ggccggatgc gaacaaagtg ggcagccaga gcgaaacccg ccgcggccgc 2220
cgcggcaccc gcgaagaaac cctggaaaaa tggattaccg cgcgcaaaaa agcggaagaa 2280
ctggaaaaag atctgcgcaa aacccgcaaa accattaaaa aactggaaga agaaaacccg 2340
tggctgggca acattgtggg cattattcgc aaaggcaaag atggcgaagg cgcgccgccg 2400
gcgaaacgcc cgcgcaccga tcagatggaa gtggatagcg gcccgggcaa acgcccgcat 2460
aaaagcggct ttaccgataa agaacgcgaa gatcatcgcc gccgcaaagc gctggaaaac 2520
aaaaaaaaac agctgagcgc gggcggcaaa attctgagca aagaagaaga agaagaactg 2580
cgccgcctga ccgatgaaga tgaagaacgc aaacgccgcg tggcgggccc gcgcgtgggc 2640
gatgtgaacc cgagccgcgg cggcccgcgc ggcgcgccgg gcggcggctt tgtgccgcag 2700
atggcgggcg tgccggaaag cccgtttagc cgcaccggcg aaggcctgga tattcgcggc 2760
acccagggct ttccgtgggt gagcccgagc ccgccgcagc agcgcctgcc gctgctggaa 2820
tgcaccccgc agagccagag cgaaagcaaa aaaaaccgcc gcggcggccg cgaagatatt 2880
ctggaaaaat ggattaccac ccgccgcaaa gcggaagaac tggaaaaaga tctgcgcaaa 2940
gcgcgcaaaa ccattaaaaa actggaagat gaaaacccgt ggctgggcaa cattattggc 3000
attattcgca aaggcaaaga tggcgaaggc gcgccgccgg cgaaacgccc gcgcaccgat 3060
cagatggaaa ttgatagcgg caccggcaaa cgcccgcata aaagcggctt taccgataaa 3120
gaacgcgaag atcatcgccg ccgcaaagcg ctggaaaaca aaaaaaaaca gctgagcagc 3180
ggcggcaaaa acctgagccg cgaagaagaa gaagaactgg gccgcctgac cgtggaagat 3240
gaagaacgcc gccgccgcgt ggcgggcccg cgcaccggcg atgtgaacct gagcggcggc 3300
ggcccgcgcg gcgcgccggg cggcggcttt gtgccgcgca tggaaggcgt gccggaaagc 3360
ccgtttaccc gcaccggcga aggcctggat attcgcggca accagggctt tccgtgggtg 3420
cgcccgagcc cgccgcagca gcgcctgccg ctgctggaat gcaccccgca gggcaccaac 3480
ctgagcacca gcaacccgct gggctttttt ccggatcatc agctggatcc ggcgtttcgc 3540
gcgaacagcg cgaacccgga ttgggatttt aacccgaaca aagatacctg gccggatgcg 3600
aacaaagtgg gcggccagaa cctgagcacc agcaacccgc tgggcttttt tccggatcat 3660
cagctggatc cggcgtttcg cgcgaacacc gcgaacccgg attgggattt taacccgaac 3720
aaagatacct ggccggatgc gaacaaagtg ggc                              3753

<210> 21
<211> 3785
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 3 wt + with restriction sites (HindIII
      /EcoRI)

<400> 21
aagcttgcac catggccggc accaacctga gcaccagcaa cccgctgggc ttttttccgg 60
atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc 120
cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca 180
acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga 240
acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggca 300
gccgcagcga aagcaaaaaa aaccgcggcg gccgcgaaga aattctggaa cagtgggtgg 360
gcgcgcgcaa aaaactggaa gaactggaac gcgatctgcg caaaattaaa aaaaaaatta 420
aaaaactgga agaagaaaac ccgtggctgg gcaacattaa aggcattctg ggcaaaaaag 480
atcgcgaagg cgaaggcgcg ccgccggcga aacgcgcgcg cgcggatcag atggaagtgg 540
atagcggccc gcgcaaacgc ccgtttcgcg gcgaatttac cgataaagaa cgccgcgatc 600
atcgccgccg caaagcgctg gaaaacaaac gcaaacagct gagcagcggc ggcaaaagcc 660
tgagcaaaga agaagaagaa gaactgcgca aactgaccga agaagatgaa cgccgcgaac 720
gccgcgtggc gggcccgcgc gtgggcggcg tgaacccgct ggaaggcggc acccgcggcg 780
cgccgggcgg cggctttgtg ccgagcatgc agggcgtgcc ggaaagcccg tttgcgcgca 840
ccggcgaagg cctggatgtg cgcggcaacc agggctttcc gtgggatatt ctgtttccgg 900
cggatccgcc gtttagcccg cagagctgcc gcccgcagag ccgcagcgaa agcaaaaaaa 960
accgcggcgg ccgcgaagaa gtgctggaac agtgggtgaa cggccgcaaa aaactggaag 1020
aactggaacg cgaactgcgc cgcgcgcgca aaaaaattaa aaaactggaa gatgataacc 1080
cgtggctggg caacgtgaaa ggcattctgg gcaaaaaaga taaagatggc gaaggcgcgc 1140
cgccggcgaa acgcgcgcgc accgatcaga tggaaattga tagcggcccg cgcaaacgcc 1200
cgctgcgcgg cggctttacc gatcgcgaac gccaggatca tcgccgccgc aaagcgctga 1260
aaaacaaaaa aaaacagctg agcgcgggcg gcaaaagcct gagcaaagaa gaagaagaag 1320
aactgaaacg cctgacccgc gaagatgaag aacgcaaaaa agaagaacat ggcccgagcc 1380
gcctgggcgt gaacccgagc gaaggcggcc cgcgcggcgc gccgggcggc ggctttgtgc 1440
cgagcatgca gggcattccg gaaagccgct ttacccgcac cggcgaaggc ctggatgtgc 1500
gcggcagccg cggctttccg caggatattc tgtttccgag cgatccgccg tttagcccgc 1560
agagctgccg cccgcagggc accaacctga gcaccagcaa cccgctgggc ttttttccgg 1620
atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc 1680
cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca 1740
acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga 1800
acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggcg 1860
gaagcggagc tactaacttc agcctgctga agcaggctgg agacgtggag gagaaccctg 1920
gacctatggg caccaacctg agcaccagca acccgctggg cttttttccg gatcatcagc 1980
tggatccggc gtttcgcgcg aacagcgcga acccggattg ggattttaac ccgaacaaag 2040
atacctggcc ggatgcgaac aaagtgggcg gccagaacct gagcaccagc aacccgctgg 2100
gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacaccgcg aacccggatt 2160
gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc agccagagcg 2220
aaacccgccg cggccgccgc ggcacccgcg aagaaaccct ggaaaaatgg attaccgcgc 2280
gcaaaaaagc ggaagaactg gaaaaagatc tgcgcaaaac ccgcaaaacc attaaaaaac 2340
tggaagaaga aaacccgtgg ctgggcaaca ttgtgggcat tattcgcaaa ggcaaagatg 2400
gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaagtg gatagcggcc 2460
cgggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat catcgccgcc 2520
gcaaagcgct ggaaaacaaa aaaaaacagc tgagcgcggg cggcaaaatt ctgagcaaag 2580
aagaagaaga agaactgcgc cgcctgaccg atgaagatga agaacgcaaa cgccgcgtgg 2640
cgggcccgcg cgtgggcgat gtgaacccga gccgcggcgg cccgcgcggc gcgccgggcg 2700
gcggctttgt gccgcagatg gcgggcgtgc cggaaagccc gtttagccgc accggcgaag 2760
gcctggatat tcgcggcacc cagggctttc cgtgggtgag cccgagcccg ccgcagcagc 2820
gcctgccgct gctggaatgc accccgcaga gccagagcga aagcaaaaaa aaccgccgcg 2880
gcggccgcga agatattctg gaaaaatgga ttaccacccg ccgcaaagcg gaagaactgg 2940
aaaaagatct gcgcaaagcg cgcaaaacca ttaaaaaact ggaagatgaa aacccgtggc 3000
tgggcaacat tattggcatt attcgcaaag gcaaagatgg cgaaggcgcg ccgccggcga 3060
aacgcccgcg caccgatcag atggaaattg atagcggcac cggcaaacgc ccgcataaaa 3120
gcggctttac cgataaagaa cgcgaagatc atcgccgccg caaagcgctg gaaaacaaaa 3180
aaaaacagct gagcagcggc ggcaaaaacc tgagccgcga agaagaagaa gaactgggcc 3240
gcctgaccgt ggaagatgaa gaacgccgcc gccgcgtggc gggcccgcgc accggcgatg 3300
tgaacctgag cggcggcggc ccgcgcggcg cgccgggcgg cggctttgtg ccgcgcatgg 3360
aaggcgtgcc ggaaagcccg tttacccgca ccggcgaagg cctggatatt cgcggcaacc 3420
agggctttcc gtgggtgcgc ccgagcccgc cgcagcagcg cctgccgctg ctggaatgca 3480
ccccgcaggg caccaacctg agcaccagca acccgctggg cttttttccg gatcatcagc 3540
tggatccggc gtttcgcgcg aacagcgcga acccggattg ggattttaac ccgaacaaag 3600
atacctggcc ggatgcgaac aaagtgggcg gccagaacct gagcaccagc aacccgctgg 3660
gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacaccgcg aacccggatt 3720
gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc tgatgagaat 3780
tccgt                                                             3785

<210> 22
<211> 3756
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 3 optimized

<400> 22
gccggcacca atctgtctac ctcaaatccc ctgggcttct tccccgatca tcagctggac 60
cctgccttcc gagcaaattc cgctaatcct gattgggatt tcaacccaaa taaggacaca 120
tggccagatg ccaacaaggt cggcggccag aacctgtcca cctctaatcc tctgggcttc 180
tttccagacc accagctgga tcccgccttc agggccaaca cagccaatcc cgactgggac 240
ttcaacccta ataaggacac ctggcctgac gccaacaagg tcggcagcag gtccgagtct 300
aagaagaata ggggaggaag ggaggagatc ctggagcagt gggtgggagc acgcaagaag 360
ctggaggagc tggagcggga cctgagaaag atcaagaaga agatcaagaa gctggaggag 420
gagaacccct ggctgggcaa tatcaagggc atcctgggca agaaggatcg ggagggagag 480
ggagcaccac ctgcaaagag ggccagagcc gaccagatgg aggtggattc cggaccaagg 540
aagcgccctt tcagaggaga gtttacagac aaggagcgga gagatcacag gcgccggaag 600
gccctggaga acaagcggaa gcagctgagc tccggcggca agagcctgtc caaggaggag 660
gaggaggagc tgagaaagct gaccgaggag gacgagagaa gggagaggag ggtggccggc 720
cccagggtgg gcggcgtgaa ccctctggag ggaggaacaa ggggagcacc aggaggaggc 780
ttcgtgcctt ccatgcaggg cgtgcccgag tctccttttg ccaggaccgg agagggcctg 840
gacgtgcgcg gcaatcaggg cttcccatgg gacatcctgt ttcccgccga tccacccttc 900
tctccccaga gctgcaggcc tcagtctcgc agcgagtcca agaagaacag aggcggaagg 960
gaggaggtgc tggagcagtg ggtgaatggc aggaagaagc tggaagaact ggagagggag 1020
ctgagaaggg cccgcaagaa gatcaagaag ctggaagacg ataatccttg gctgggcaat 1080
gtgaaaggca tcctgggcaa gaaggacaag gatggagagg gagcacctcc agcaaagagg 1140
gcaagaacag accagatgga gatcgattct ggaccaagga agcgccccct gaggggaggc 1200
ttcaccgacc gggagagaca ggatcaccgc cggagaaagg ccctgaagaa caagaagaag 1260
cagctgagcg ccggcggcaa gtctctgagt aaagaagaag aggaggagct gaagcggctg 1320
accagagagg acgaggagcg gaagaaggag gagcacggcc caagcagact gggagtgaat 1380
ccatccgagg gaggacctag aggcgcccct ggcggcggct tcgtgccttc tatgcagggc 1440
atcccagaga gcaggtttac caggacaggc gaaggcctgg acgtgcgggg ctccagaggc 1500
tttccccagg acatcctgtt cccttctgat cccccttttt ccccacagtc ttgtaggccc 1560
cagggcacca acctgtccac atctaaccca ctgggcttct ttcctgatca ccagctggat 1620
ccagccttcc gcgccaactc cgccaatcca gactgggact tcaaccccaa taaggacaca 1680
tggcctgatg ctaacaaggt cggaggccag aacctgagca cctccaatcc cctgggcttc 1740
tttcctgacc accagctgga tcctgccttc cgcgccaaca cagctaaccc tgattgggac 1800
ttcaacccaa ataaggatac ctggcctgat gcaaacaagg tcggaggaag cggagctact 1860
aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatgggcacc 1920
aacctgtcta caagcaatcc actgggcttc tttcccgacc atcagctgga cccagccttc 1980
agggccaaca gcgccaaccc tgactgggac ttcaacccaa ataaggacac gtggcctgat 2040
gccaacaagg tcggaggaca aaacctgtcc acctctaacc ccctgggctt ctttcccgat 2100
catcaattag acccagcctt ccgcgctaac actgctaacc ctgactggga cttcaacccg 2160
aataaggata cttggcctga tgccaataag gtcggcagcc agtccgagac aaggaggggc 2220
cggagaggaa ccagggagga gacactggag aagtggatca ccgccagaaa gaaggccgag 2280
gagctggaga aggacctgag gaagacccgc aagacaatca agaagctgga agaagagaac 2340
ccttggctgg gcaatatcgt gggcatcatc agaaagggca aggacggcga gggagcacca 2400
ccagccaaga ggccacgcac agatcagatg gaagtggata gcggaccagg caagaggcct 2460
cacaagtccg gcttcaccga caaggagagg gaggaccata ggcgccggaa ggccctggaa 2520
aacaagaaga agcaattatc cgccggcggc aagatcctgt ctaaagaaga ggaagaagag 2580
ctgagaaggc tgaccgacga ggatgaggag aggaagagga gggtggcagg acctagagtg 2640
ggcgacgtga atccatccag gggaggacca agaggagcac caggaggcgg cttcgtgcca 2700
cagatggcag gagtgccaga gagccccttt tccaggacag gagagggcct ggatatcagg 2760
ggaacccagg gctttccttg ggtgtctcca agccctccac agcagcggct gccactgctg 2820
gagtgcacac cccagtccca gtctgagagc aagaagaaca gaaggggcgg cagagaggac 2880
atcctggaaa aatggatcac cacacgcaga aaagctgaag aactggaaaa ggacctgcgg 2940
aaggccagaa agaccatcaa gaagctggag gatgaaaatc catggctggg aaatatcatc 3000
ggcatcatcc ggaagggcaa ggacggggaa ggcgcaccac ctgcaaagcg gcccaggacc 3060
gatcagatgg aaatcgattc tggaaccggc aagcggcctc acaagagtgg cttcaccgat 3120
aaggagagag aggatcacag aaggcgcaag gccctggaga acaagaagaa gcaattaagc 3180
agcggcggca agaatctgtc cagagaagag gaagaggagc tgggcagact gacagtggag 3240
gacgaggagc ggagaaggcg cgtggcagga ccaagaaccg gcgatgtgaa cctgtccgga 3300
ggaggaccaa ggggagcacc tgggggaggc ttcgtgccaa ggatggaggg agtgcctgag 3360
tcccccttca ccagaaccgg cgaaggcctg gacatcaggg gcaatcaggg attcccatgg 3420
gtgcggccct ccccacccca gcagagactg cctctgctgg agtgtacccc acagggcact 3480
aacctgtcca cctctaaccc gttaggcttc tttcctgacc atcaattaga tcccgccttc 3540
cgggccaaca gcgccaatcc tgattgggac ttcaacccga ataaggacac ctggcccgac 3600
gcaaacaagg tcggagggca aaacctgagc acctccaacc ctttaggctt ctttccagat 3660
catcagctgg atccagcctt tagagccaat accgccaacc ctgactggga tttcaaccct 3720
aacaaagata cctggcccga cgctaacaaa gtggga                           3756

<210> 23
<211> 3785
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 3 codon optimized with restriction sites
      (HindIII/EcoR1)

<400> 23
aagcttgcac catggccggc accaatctgt ctacctcaaa tcccctgggc ttcttccccg 60
atcatcagct ggaccctgcc ttccgagcaa attccgctaa tcctgattgg gatttcaacc 120
caaataagga cacatggcca gatgccaaca aggtcggcgg ccagaacctg tccacctcta 180
atcctctggg cttctttcca gaccaccagc tggatcccgc cttcagggcc aacacagcca 240
atcccgactg ggacttcaac cctaataagg acacctggcc tgacgccaac aaggtcggca 300
gcaggtccga gtctaagaag aataggggag gaagggagga gatcctggag cagtgggtgg 360
gagcacgcaa gaagctggag gagctggagc gggacctgag aaagatcaag aagaagatca 420
agaagctgga ggaggagaac ccctggctgg gcaatatcaa gggcatcctg ggcaagaagg 480
atcgggaggg agagggagca ccacctgcaa agagggccag agccgaccag atggaggtgg 540
attccggacc aaggaagcgc cctttcagag gagagtttac agacaaggag cggagagatc 600
acaggcgccg gaaggccctg gagaacaagc ggaagcagct gagctccggc ggcaagagcc 660
tgtccaagga ggaggaggag gagctgagaa agctgaccga ggaggacgag agaagggaga 720
ggagggtggc cggccccagg gtgggcggcg tgaaccctct ggagggagga acaaggggag 780
caccaggagg aggcttcgtg ccttccatgc agggcgtgcc cgagtctcct tttgccagga 840
ccggagaggg cctggacgtg cgcggcaatc agggcttccc atgggacatc ctgtttcccg 900
ccgatccacc cttctctccc cagagctgca ggcctcagtc tcgcagcgag tccaagaaga 960
acagaggcgg aagggaggag gtgctggagc agtgggtgaa tggcaggaag aagctggaag 1020
aactggagag ggagctgaga agggcccgca agaagatcaa gaagctggaa gacgataatc 1080
cttggctggg caatgtgaaa ggcatcctgg gcaagaagga caaggatgga gagggagcac 1140
ctccagcaaa gagggcaaga acagaccaga tggagatcga ttctggacca aggaagcgcc 1200
ccctgagggg aggcttcacc gaccgggaga gacaggatca ccgccggaga aaggccctga 1260
agaacaagaa gaagcagctg agcgccggcg gcaagtctct gagtaaagaa gaagaggagg 1320
agctgaagcg gctgaccaga gaggacgagg agcggaagaa ggaggagcac ggcccaagca 1380
gactgggagt gaatccatcc gagggaggac ctagaggcgc ccctggcggc ggcttcgtgc 1440
cttctatgca gggcatccca gagagcaggt ttaccaggac aggcgaaggc ctggacgtgc 1500
ggggctccag aggctttccc caggacatcc tgttcccttc tgatccccct ttttccccac 1560
agtcttgtag gccccagggc accaacctgt ccacatctaa cccactgggc ttctttcctg 1620
atcaccagct ggatccagcc ttccgcgcca actccgccaa tccagactgg gacttcaacc 1680
ccaataagga cacatggcct gatgctaaca aggtcggagg ccagaacctg agcacctcca 1740
atcccctggg cttctttcct gaccaccagc tggatcctgc cttccgcgcc aacacagcta 1800
accctgattg ggacttcaac ccaaataagg atacctggcc tgatgcaaac aaggtcggag 1860
gaagcggagc tactaacttc agcctgctga agcaggctgg agacgtggag gagaaccctg 1920
gacctatggg caccaacctg tctacaagca atccactggg cttctttccc gaccatcagc 1980
tggacccagc cttcagggcc aacagcgcca accctgactg ggacttcaac ccaaataagg 2040
acacgtggcc tgatgccaac aaggtcggag gacaaaacct gtccacctct aaccccctgg 2100
gcttctttcc cgatcatcaa ttagacccag ccttccgcgc taacactgct aaccctgact 2160
gggacttcaa cccgaataag gatacttggc ctgatgccaa taaggtcggc agccagtccg 2220
agacaaggag gggccggaga ggaaccaggg aggagacact ggagaagtgg atcaccgcca 2280
gaaagaaggc cgaggagctg gagaaggacc tgaggaagac ccgcaagaca atcaagaagc 2340
tggaagaaga gaacccttgg ctgggcaata tcgtgggcat catcagaaag ggcaaggacg 2400
gcgagggagc accaccagcc aagaggccac gcacagatca gatggaagtg gatagcggac 2460
caggcaagag gcctcacaag tccggcttca ccgacaagga gagggaggac cataggcgcc 2520
ggaaggccct ggaaaacaag aagaagcaat tatccgccgg cggcaagatc ctgtctaaag 2580
aagaggaaga agagctgaga aggctgaccg acgaggatga ggagaggaag aggagggtgg 2640
caggacctag agtgggcgac gtgaatccat ccaggggagg accaagagga gcaccaggag 2700
gcggcttcgt gccacagatg gcaggagtgc cagagagccc cttttccagg acaggagagg 2760
gcctggatat caggggaacc cagggctttc cttgggtgtc tccaagccct ccacagcagc 2820
ggctgccact gctggagtgc acaccccagt cccagtctga gagcaagaag aacagaaggg 2880
gcggcagaga ggacatcctg gaaaaatgga tcaccacacg cagaaaagct gaagaactgg 2940
aaaaggacct gcggaaggcc agaaagacca tcaagaagct ggaggatgaa aatccatggc 3000
tgggaaatat catcggcatc atccggaagg gcaaggacgg ggaaggcgca ccacctgcaa 3060
agcggcccag gaccgatcag atggaaatcg attctggaac cggcaagcgg cctcacaaga 3120
gtggcttcac cgataaggag agagaggatc acagaaggcg caaggccctg gagaacaaga 3180
agaagcaatt aagcagcggc ggcaagaatc tgtccagaga agaggaagag gagctgggca 3240
gactgacagt ggaggacgag gagcggagaa ggcgcgtggc aggaccaaga accggcgatg 3300
tgaacctgtc cggaggagga ccaaggggag cacctggggg aggcttcgtg ccaaggatgg 3360
agggagtgcc tgagtccccc ttcaccagaa ccggcgaagg cctggacatc aggggcaatc 3420
agggattccc atgggtgcgg ccctccccac cccagcagag actgcctctg ctggagtgta 3480
ccccacaggg cactaacctg tccacctcta acccgttagg cttctttcct gaccatcaat 3540
tagatcccgc cttccgggcc aacagcgcca atcctgattg ggacttcaac ccgaataagg 3600
acacctggcc cgacgcaaac aaggtcggag ggcaaaacct gagcacctcc aaccctttag 3660
gcttctttcc agatcatcag ctggatccag cctttagagc caataccgcc aaccctgact 3720
gggatttcaa ccctaacaaa gatacctggc ccgacgctaa caaagtggga tgatgagaat 3780
tccgt                                                             3785

<210> 24
<211> 1253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 3 protein

<400> 24
Met Ala Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro
 1               5                  10                  15      
Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp
            20                  25                  30          
Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val
        35                  40                  45              
Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp
    50                  55                  60                  
His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp
65                  70                  75                  80  
Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
                85                  90                  95      
Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu
            100                 105                 110         
Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp
        115                 120                 125             
Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro
    130                 135                 140                 
Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly
145                 150                 155                 160 
Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val
                165                 170                 175     
Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys
            180                 185                 190         
Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys
        195                 200                 205             
Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu
    210                 215                 220                 
Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala
225                 230                 235                 240 
Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly
                245                 250                 255     
Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser
            260                 265                 270         
Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly
        275                 280                 285             
Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln
    290                 295                 300                 
Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly
305                 310                 315                 320 
Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu
                325                 330                 335     
Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu
            340                 345                 350         
Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys
        355                 360                 365             
Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr
    370                 375                 380                 
Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly
385                 390                 395                 400 
Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu
                405                 410                 415     
Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys
            420                 425                 430         
Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg
        435                 440                 445             
Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu
    450                 455                 460                 
Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln
465                 470                 475                 480 
Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val
                485                 490                 495     
Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro
            500                 505                 510         
Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu Ser Thr
        515                 520                 525             
Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe
    530                 535                 540                 
Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp
545                 550                 555                 560 
Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser
                565                 570                 575     
Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg
            580                 585                 590         
Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr
        595                 600                 605             
Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe Ser
    610                 615                 620                 
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly
625                 630                 635                 640 
Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln
                645                 650                 655     
Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe
            660                 665                 670         
Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln
        675                 680                 685             
Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu
    690                 695                 700                 
Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn
705                 710                 715                 720 
Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ser Gln Ser
                725                 730                 735     
Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu Glu Lys
            740                 745                 750         
Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg
        755                 760                 765             
Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro Trp Leu
    770                 775                 780                 
Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala
785                 790                 795                 800 
Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp Ser Gly
                805                 810                 815     
Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu
            820                 825                 830         
Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser
        835                 840                 845             
Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu Arg Arg
    850                 855                 860                 
Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly Pro Arg
865                 870                 875                 880 
Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala Pro Gly
                885                 890                 895     
Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro Phe Ser
            900                 905                 910         
Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe Pro Trp
        915                 920                 925             
Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr
    930                 935                 940                 
Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly Arg Glu
945                 950                 955                 960 
Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu Glu Leu
                965                 970                 975     
Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu Glu Asp
            980                 985                 990         
Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile Arg Lys Gly Lys
        995                 1000                1005            
Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met
    1010                1015                1020                
Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys Ser Gly Phe Thr
1025                1030                1035               1040 
Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
                1045                1050                1055    
Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser Arg Glu Glu Glu
            1060                1065                1070        
Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu Arg Arg Arg Arg
        1075                1080                1085            
Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser Gly Gly Gly Pro
    1090                1095                1100                
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met Glu Gly Val Pro
1105                1110                1115               1120 
Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Asn
                1125                1130                1135    
Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln Gln Arg Leu Pro
            1140                1145                1150        
Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro
        1155                1160                1165            
Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn
    1170                1175                1180                
Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro
1185                1190                1195               1200 
Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu
                1205                1210                1215    
Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr
            1220                1225                1230        
Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp
        1235                1240                1245            
Ala Asn Lys Val Gly
    1250            


<210> 25
<211> 3891
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 4 wt

<400> 25
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcagg gcaccaacct gagcaccagc 660
aacccgctgg gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacagcgcg 720
aacccggatt gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc 780
ggccagaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 840
gcgtttcgcg cgaacaccgc gaacccggat tgggatttta acccgaacaa agatacctgg 900
ccggatgcga acaaagtggg cggaagcgga gctactaact tcagcctgct gaagcaggct 960
ggagacgtgg aggagaaccc tggacctatg agccgcagcg aaagcaaaaa aaaccgcggc 1020
ggccgcgaag aagtgctgga acagtgggtg aacggccgca aaaaactgga agaactggaa 1080
cgcgaactgc gccgcgcgcg caaaaaaatt aaaaaactgg aagatgataa cccgtggctg 1140
ggcaacgtga aaggcattct gggcaaaaaa gataaagatg gcgaaggcgc gccgccggcg 1200
aaacgcgcgc gcaccgatca gatggaaatt gatagcggcc cgcgcaaacg cccgctgcgc 1260
ggcggcttta ccgatcgcga acgccaggat catcgccgcc gcaaagcgct gaaaaacaaa 1320
aaaaaacagc tgagcgcggg cggcaaaagc ctgagcaaag aagaagaaga agaactgaaa 1380
cgcctgaccc gcgaagatga agaacgcaaa aaagaagaac atggcccgag ccgcctgggc 1440
gtgaacccga gcgaaggcgg cccgcgcggc gcgccgggcg gcggctttgt gccgagcatg 1500
cagggcattc cggaaagccg ctttacccgc accggcgaag gcctggatgt gcgcggcagc 1560
cgcggctttc cgcaggatat tctgtttccg agcgatccgc cgtttagccc gcagagctgc 1620
cgcccgcagg gcaccaacct gagcaccagc aacccgctgg gcttttttcc ggatcatcag 1680
ctggatccgg cgtttcgcgc gaacagcgcg aacccggatt gggattttaa cccgaacaaa 1740
gatacctggc cggatgcgaa caaagtgggc ggccagaacc tgagcaccag caacccgctg 1800
ggcttttttc cggatcatca gctggatccg gcgtttcgcg cgaacaccgc gaacccggat 1860
tgggatttta acccgaacaa agatacctgg ccggatgcga acaaagtggg cggaagcgga 1920
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctatg 1980
agccagagcg aaacccgccg cggccgccgc ggcacccgcg aagaaaccct ggaaaaatgg 2040
attaccgcgc gcaaaaaagc ggaagaactg gaaaaagatc tgcgcaaaac ccgcaaaacc 2100
attaaaaaac tggaagaaga aaacccgtgg ctgggcaaca ttgtgggcat tattcgcaaa 2160
ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaagtg 2220
gatagcggcc cgggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat 2280
catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcgcggg cggcaaaatt 2340
ctgagcaaag aagaagaaga agaactgcgc cgcctgaccg atgaagatga agaacgcaaa 2400
cgccgcgtgg cgggcccgcg cgtgggcgat gtgaacccga gccgcggcgg cccgcgcggc 2460
gcgccgggcg gcggctttgt gccgcagatg gcgggcgtgc cggaaagccc gtttagccgc 2520
accggcgaag gcctggatat tcgcggcacc cagggctttc cgtgggtgag cccgagcccg 2580
ccgcagcagc gcctgccgct gctggaatgc accccgcagg gcaccaacct gagcaccagc 2640
aacccgctgg gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacagcgcg 2700
aacccggatt gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc 2760
ggccagaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg 2820
gcgtttcgcg cgaacaccgc gaacccggat tgggatttta acccgaacaa agatacctgg 2880
ccggatgcga acaaagtggg cggaagcgga gctactaact tcagcctgct gaagcaggct 2940
ggagacgtgg aggagaaccc tggacctatg agccagagcg aaagcaaaaa aaaccgccgc 3000
ggcggccgcg aagatattct ggaaaaatgg attaccaccc gccgcaaagc ggaagaactg 3060
gaaaaagatc tgcgcaaagc gcgcaaaacc attaaaaaac tggaagatga aaacccgtgg 3120
ctgggcaaca ttattggcat tattcgcaaa ggcaaagatg gcgaaggcgc gccgccggcg 3180
aaacgcccgc gcaccgatca gatggaaatt gatagcggca ccggcaaacg cccgcataaa 3240
agcggcttta ccgataaaga acgcgaagat catcgccgcc gcaaagcgct ggaaaacaaa 3300
aaaaaacagc tgagcagcgg cggcaaaaac ctgagccgcg aagaagaaga agaactgggc 3360
cgcctgaccg tggaagatga agaacgccgc cgccgcgtgg cgggcccgcg caccggcgat 3420
gtgaacctga gcggcggcgg cccgcgcggc gcgccgggcg gcggctttgt gccgcgcatg 3480
gaaggcgtgc cggaaagccc gtttacccgc accggcgaag gcctggatat tcgcggcaac 3540
cagggctttc cgtgggtgcg cccgagcccg ccgcagcagc gcctgccgct gctggaatgc 3600
accccgcagg gcaccaacct gagcaccagc aacccgctgg gcttttttcc ggatcatcag 3660
ctggatccgg cgtttcgcgc gaacagcgcg aacccggatt gggattttaa cccgaacaaa 3720
gatacctggc cggatgcgaa caaagtgggc ggccagaacc tgagcaccag caacccgctg 3780
ggcttttttc cggatcatca gctggatccg gcgtttcgcg cgaacaccgc gaacccggat 3840
tgggatttta acccgaacaa agatacctgg ccggatgcga acaaagtggg c          3891

<210> 26
<211> 3923
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 4 wt with restriction sites (HindIII/EcoR1)

<400> 26
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagggca 660
ccaacctgag caccagcaac ccgctgggct tttttccgga tcatcagctg gatccggcgt 720
ttcgcgcgaa cagcgcgaac ccggattggg attttaaccc gaacaaagat acctggccgg 780
atgcgaacaa agtgggcggc cagaacctga gcaccagcaa cccgctgggc ttttttccgg 840
atcatcagct ggatccggcg tttcgcgcga acaccgcgaa cccggattgg gattttaacc 900
cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg aagcggagct actaacttca 960
gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatgagc cgcagcgaaa 1020
gcaaaaaaaa ccgcggcggc cgcgaagaag tgctggaaca gtgggtgaac ggccgcaaaa 1080
aactggaaga actggaacgc gaactgcgcc gcgcgcgcaa aaaaattaaa aaactggaag 1140
atgataaccc gtggctgggc aacgtgaaag gcattctggg caaaaaagat aaagatggcg 1200
aaggcgcgcc gccggcgaaa cgcgcgcgca ccgatcagat ggaaattgat agcggcccgc 1260
gcaaacgccc gctgcgcggc ggctttaccg atcgcgaacg ccaggatcat cgccgccgca 1320
aagcgctgaa aaacaaaaaa aaacagctga gcgcgggcgg caaaagcctg agcaaagaag 1380
aagaagaaga actgaaacgc ctgacccgcg aagatgaaga acgcaaaaaa gaagaacatg 1440
gcccgagccg cctgggcgtg aacccgagcg aaggcggccc gcgcggcgcg ccgggcggcg 1500
gctttgtgcc gagcatgcag ggcattccgg aaagccgctt tacccgcacc ggcgaaggcc 1560
tggatgtgcg cggcagccgc ggctttccgc aggatattct gtttccgagc gatccgccgt 1620
ttagcccgca gagctgccgc ccgcagggca ccaacctgag caccagcaac ccgctgggct 1680
tttttccgga tcatcagctg gatccggcgt ttcgcgcgaa cagcgcgaac ccggattggg 1740
attttaaccc gaacaaagat acctggccgg atgcgaacaa agtgggcggc cagaacctga 1800
gcaccagcaa cccgctgggc ttttttccgg atcatcagct ggatccggcg tttcgcgcga 1860
acaccgcgaa cccggattgg gattttaacc cgaacaaaga tacctggccg gatgcgaaca 1920
aagtgggcgg aagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg 1980
agaaccctgg acctatgagc cagagcgaaa cccgccgcgg ccgccgcggc acccgcgaag 2040
aaaccctgga aaaatggatt accgcgcgca aaaaagcgga agaactggaa aaagatctgc 2100
gcaaaacccg caaaaccatt aaaaaactgg aagaagaaaa cccgtggctg ggcaacattg 2160
tgggcattat tcgcaaaggc aaagatggcg aaggcgcgcc gccggcgaaa cgcccgcgca 2220
ccgatcagat ggaagtggat agcggcccgg gcaaacgccc gcataaaagc ggctttaccg 2280
ataaagaacg cgaagatcat cgccgccgca aagcgctgga aaacaaaaaa aaacagctga 2340
gcgcgggcgg caaaattctg agcaaagaag aagaagaaga actgcgccgc ctgaccgatg 2400
aagatgaaga acgcaaacgc cgcgtggcgg gcccgcgcgt gggcgatgtg aacccgagcc 2460
gcggcggccc gcgcggcgcg ccgggcggcg gctttgtgcc gcagatggcg ggcgtgccgg 2520
aaagcccgtt tagccgcacc ggcgaaggcc tggatattcg cggcacccag ggctttccgt 2580
gggtgagccc gagcccgccg cagcagcgcc tgccgctgct ggaatgcacc ccgcagggca 2640
ccaacctgag caccagcaac ccgctgggct tttttccgga tcatcagctg gatccggcgt 2700
ttcgcgcgaa cagcgcgaac ccggattggg attttaaccc gaacaaagat acctggccgg 2760
atgcgaacaa agtgggcggc cagaacctga gcaccagcaa cccgctgggc ttttttccgg 2820
atcatcagct ggatccggcg tttcgcgcga acaccgcgaa cccggattgg gattttaacc 2880
cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg aagcggagct actaacttca 2940
gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatgagc cagagcgaaa 3000
gcaaaaaaaa ccgccgcggc ggccgcgaag atattctgga aaaatggatt accacccgcc 3060
gcaaagcgga agaactggaa aaagatctgc gcaaagcgcg caaaaccatt aaaaaactgg 3120
aagatgaaaa cccgtggctg ggcaacatta ttggcattat tcgcaaaggc aaagatggcg 3180
aaggcgcgcc gccggcgaaa cgcccgcgca ccgatcagat ggaaattgat agcggcaccg 3240
gcaaacgccc gcataaaagc ggctttaccg ataaagaacg cgaagatcat cgccgccgca 3300
aagcgctgga aaacaaaaaa aaacagctga gcagcggcgg caaaaacctg agccgcgaag 3360
aagaagaaga actgggccgc ctgaccgtgg aagatgaaga acgccgccgc cgcgtggcgg 3420
gcccgcgcac cggcgatgtg aacctgagcg gcggcggccc gcgcggcgcg ccgggcggcg 3480
gctttgtgcc gcgcatggaa ggcgtgccgg aaagcccgtt tacccgcacc ggcgaaggcc 3540
tggatattcg cggcaaccag ggctttccgt gggtgcgccc gagcccgccg cagcagcgcc 3600
tgccgctgct ggaatgcacc ccgcagggca ccaacctgag caccagcaac ccgctgggct 3660
tttttccgga tcatcagctg gatccggcgt ttcgcgcgaa cagcgcgaac ccggattggg 3720
attttaaccc gaacaaagat acctggccgg atgcgaacaa agtgggcggc cagaacctga 3780
gcaccagcaa cccgctgggc ttttttccgg atcatcagct ggatccggcg tttcgcgcga 3840
acaccgcgaa cccggattgg gattttaacc cgaacaaaga tacctggccg gatgcgaaca 3900
aagtgggctg atgagaattc cgt                                         3923

<210> 27
<211> 3894
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 4 codon optimized

<400> 27
gccagtcgga gcgaatcaaa gaaaaatagg ggagggcggg aagaaatcct ggagcagtgg 60
gtcggagcac gaaagaaact ggaagaactg gagagggacc tgcgcaagat caagaagaag 120
atcaagaagc tggaggagga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggatcggg agggagaggg agcaccacct gcaaagaggg ccagagccga ccagatggag 240
gtggatagcg gccctaggaa gcgcccattc agaggcgagt ttacagacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagcggaagc agctgagctc cggcggcaag 360
tccctgtcta aggaggagga ggaggagctg agaaagctga ccgaggagga cgagagaagg 420
gagaggaggg tggcaggacc tagggtggga ggcgtgaacc cactggaggg aggaacaagg 480
ggagcacctg gaggaggatt cgtgccatcc atgcagggag tgcctgagtc tccatttgcc 540
aggaccggag agggcctgga tgtgcgcgga aatcagggct tcccctggga catcctgttt 600
cctgccgatc cacccttctc cccacagtct tgcaggccac agggaaccaa cctgagcaca 660
tccaatcctc tgggcttctt tccagaccac cagctggatc ctgccttcag agccaactcc 720
gccaatccag actgggactt caaccccaat aaggacacat ggcctgatgc caacaaggtc 780
ggcggccaga acctgtctac cagcaatccc ctgggcttct ttcctgacca ccagctggat 840
ccagccttcc gggccaacac tgctaaccct gattgggact tcaaccctaa taaggatacc 900
tggccagacg ccaacaaggt cggcggaagc ggagctacta acttcagcct gctgaagcag 960
gctggagacg tggaggagaa ccctggacct atgtccaggt ctgagagcaa gaagaatagg 1020
ggaggaagag aggaggtgct ggagcagtgg gtgaacggcc gcaagaagct ggaggagctg 1080
gagagggagc tgagaagggc ccgcaagaag atcaagaagc tggaagacga taatccttgg 1140
ctgggcaatg tgaaaggcat cctgggcaag aaggacaagg atggagaggg agcacctcca 1200
gcaaagaggg caagaacaga ccagatggag atcgattctg gaccaaggaa gcgccctctg 1260
aggggaggct tcaccgaccg ggagagacag gatcaccgcc ggagaaaggc cctgaagaac 1320
aagaagaagc agctgtccgc cggcggcaag tccctgagca aagaagagga agaggagctg 1380
aagaggctga cccgcgagga cgaggagcgg aagaaggagg agcacggacc aagcagactg 1440
ggagtgaatc cttccgaggg aggaccaaga ggagcacccg gaggaggctt cgtgccatct 1500
atgcagggca tccccgagag ccggtttacc agaacaggag agggcctgga cgtgaggggc 1560
tcccgcggct ttcctcagga catcctgttc ccatctgatc ccccttttag cccacagtcc 1620
tgtaggcccc agggcactaa cctgagcaca tccaacccac tgggcttctt tcctgatcat 1680
cagctggacc cagccttccg cgccaacagc gccaaccctg actgggactt caacccaaat 1740
aaggacacat ggccagatgc taacaaggtc ggaggacaaa acctgtctac cagcaaccct 1800
ctgggcttct ttcccgatca tcagctggac cccgccttca gggccaacac agccaatccc 1860
gactgggact tcaacccgaa taaggacacc tggccagatg caaacaaggt cggaggaagc 1920
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct 1980
atgagccagt ctgagacaag gaggggccgg agaggaacca gggaggagac actggagaag 2040
tggatcaccg ccagaaagaa ggccgaggag ctggagaagg acctgcggaa gaccagaaag 2100
acaatcaaga agctggaaga agagaaccca tggctgggca atatcgtggg catcatccgc 2160
aagggcaagg acggcgaggg agcaccacca gcaaagaggc cccgcacaga tcagatggaa 2220
gtggatagcg gccctggcaa gaggccacac aagtccggct tcaccgacaa ggagagggag 2280
gaccataggc gccggaaggc cctggaaaac aagaagaagc aattatccgc cggcggcaag 2340
atcctgtcca aagaggaaga agaggagctg agaaggctga ccgacgagga tgaggagagg 2400
aaaagaaggg tggcaggacc aagagtgggc gacgtgaatc ccagcagagg cggaccaaga 2460
ggagcacctg gaggcggctt cgtgccccag atggccggcg tgcccgagtc tccttttagc 2520
agaactggag agggcctgga tatcagggga acacagggct ttccatgggt gagcccatcc 2580
cctccacagc agaggctgcc actgctggag tgcacccctc agggaaccaa cctgtctacc 2640
agcaacccgc tgggcttctt tcccgaccat cagctggacc ctgccttccg cgccaactcc 2700
gccaaccctg attgggactt caacccgaat aaggatacct ggcccgacgc taacaaggtc 2760
ggaggccaga acctgtccac ctctaacccc ttaggcttct ttcccgatca ccagctggat 2820
cccgccttca gagccaacac tgctaacccc gattgggact tcaacccgaa taaggacacg 2880
tggccagacg ctaacaaggt cgggggaagc ggagctacta acttcagcct gctgaagcag 2940
gctggagacg tggaggagaa ccctggacct atgtcgcagt ccgagtctaa gaagaataga 3000
aggggcggcc gggaggatat cctggaaaaa tggatcacca cacgcagaaa agctgaagaa 3060
ctggaaaagg acctgaggaa ggcccgcaag accatcaaga agctggagga tgaaaatcca 3120
tggctgggaa acatcatcgg catcatcaga aagggcaagg acggggaagg cgccccacct 3180
gcaaagcggc ctagaaccga tcagatggaa atcgattctg gcacaggcaa gcggccacac 3240
aagagtggct tcaccgataa ggagagagag gatcacagaa ggcgcaaggc cctggagaac 3300
aagaagaagc aattaagcag cggcggcaag aatctgtcca gagaagaaga ggaggagctg 3360
ggcagactga cagtggagga cgaggagcgg agaaggcgcg tggcaggacc aaggaccggc 3420
gatgtgaacc tgagcggagg aggacctagg ggagcaccag gaggcggctt cgtgcctagg 3480
atggagggag tgccagagtc cccctttacc aggactggcg agggcctgga catcagggga 3540
aatcagggat tcccatgggt gcggcctagc ccaccacagc agagactgcc actgctggag 3600
tgtacacccc agggcacaaa cctgagcaca tccaatccgc tgggcttctt tccagatcat 3660
caattagatc cagccttcag ggccaactcc gccaatccgg attgggactt caacccgaat 3720
aaggacactt ggcccgacgc aaacaaggtc ggagggcaaa acctgtctac cagcaatcca 3780
cttggcttct ttcctgacca tcagctggat cccgcctttc gcgccaatac cgccaatcct 3840
gactgggact tcaatcctaa caaagacacc tggcccgacg caaacaaagt ggga       3894

<210> 28
<211> 3923
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 4 optimized with restriction sites (HindIII
      /EcoRI)

<400> 28
aagcttgcac catggccagt cggagcgaat caaagaaaaa taggggaggg cgggaagaaa 60
tcctggagca gtgggtcgga gcacgaaaga aactggaaga actggagagg gacctgcgca 120
agatcaagaa gaagatcaag aagctggagg aggagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat cgggagggag agggagcacc acctgcaaag agggccagag 240
ccgaccagat ggaggtggat agcggcccta ggaagcgccc attcagaggc gagtttacag 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagcgg aagcagctga 360
gctccggcgg caagtccctg tctaaggagg aggaggagga gctgagaaag ctgaccgagg 420
aggacgagag aagggagagg agggtggcag gacctagggt gggaggcgtg aacccactgg 480
agggaggaac aaggggagca cctggaggag gattcgtgcc atccatgcag ggagtgcctg 540
agtctccatt tgccaggacc ggagagggcc tggatgtgcg cggaaatcag ggcttcccct 600
gggacatcct gtttcctgcc gatccaccct tctccccaca gtcttgcagg ccacagggaa 660
ccaacctgag cacatccaat cctctgggct tctttccaga ccaccagctg gatcctgcct 720
tcagagccaa ctccgccaat ccagactggg acttcaaccc caataaggac acatggcctg 780
atgccaacaa ggtcggcggc cagaacctgt ctaccagcaa tcccctgggc ttctttcctg 840
accaccagct ggatccagcc ttccgggcca acactgctaa ccctgattgg gacttcaacc 900
ctaataagga tacctggcca gacgccaaca aggtcggcgg aagcggagct actaacttca 960
gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatgtcc aggtctgaga 1020
gcaagaagaa taggggagga agagaggagg tgctggagca gtgggtgaac ggccgcaaga 1080
agctggagga gctggagagg gagctgagaa gggcccgcaa gaagatcaag aagctggaag 1140
acgataatcc ttggctgggc aatgtgaaag gcatcctggg caagaaggac aaggatggag 1200
agggagcacc tccagcaaag agggcaagaa cagaccagat ggagatcgat tctggaccaa 1260
ggaagcgccc tctgagggga ggcttcaccg accgggagag acaggatcac cgccggagaa 1320
aggccctgaa gaacaagaag aagcagctgt ccgccggcgg caagtccctg agcaaagaag 1380
aggaagagga gctgaagagg ctgacccgcg aggacgagga gcggaagaag gaggagcacg 1440
gaccaagcag actgggagtg aatccttccg agggaggacc aagaggagca cccggaggag 1500
gcttcgtgcc atctatgcag ggcatccccg agagccggtt taccagaaca ggagagggcc 1560
tggacgtgag gggctcccgc ggctttcctc aggacatcct gttcccatct gatccccctt 1620
ttagcccaca gtcctgtagg ccccagggca ctaacctgag cacatccaac ccactgggct 1680
tctttcctga tcatcagctg gacccagcct tccgcgccaa cagcgccaac cctgactggg 1740
acttcaaccc aaataaggac acatggccag atgctaacaa ggtcggagga caaaacctgt 1800
ctaccagcaa ccctctgggc ttctttcccg atcatcagct ggaccccgcc ttcagggcca 1860
acacagccaa tcccgactgg gacttcaacc cgaataagga cacctggcca gatgcaaaca 1920
aggtcggagg aagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg 1980
agaaccctgg acctatgagc cagtctgaga caaggagggg ccggagagga accagggagg 2040
agacactgga gaagtggatc accgccagaa agaaggccga ggagctggag aaggacctgc 2100
ggaagaccag aaagacaatc aagaagctgg aagaagagaa cccatggctg ggcaatatcg 2160
tgggcatcat ccgcaagggc aaggacggcg agggagcacc accagcaaag aggccccgca 2220
cagatcagat ggaagtggat agcggccctg gcaagaggcc acacaagtcc ggcttcaccg 2280
acaaggagag ggaggaccat aggcgccgga aggccctgga aaacaagaag aagcaattat 2340
ccgccggcgg caagatcctg tccaaagagg aagaagagga gctgagaagg ctgaccgacg 2400
aggatgagga gaggaaaaga agggtggcag gaccaagagt gggcgacgtg aatcccagca 2460
gaggcggacc aagaggagca cctggaggcg gcttcgtgcc ccagatggcc ggcgtgcccg 2520
agtctccttt tagcagaact ggagagggcc tggatatcag gggaacacag ggctttccat 2580
gggtgagccc atcccctcca cagcagaggc tgccactgct ggagtgcacc cctcagggaa 2640
ccaacctgtc taccagcaac ccgctgggct tctttcccga ccatcagctg gaccctgcct 2700
tccgcgccaa ctccgccaac cctgattggg acttcaaccc gaataaggat acctggcccg 2760
acgctaacaa ggtcggaggc cagaacctgt ccacctctaa ccccttaggc ttctttcccg 2820
atcaccagct ggatcccgcc ttcagagcca acactgctaa ccccgattgg gacttcaacc 2880
cgaataagga cacgtggcca gacgctaaca aggtcggggg aagcggagct actaacttca 2940
gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatgtcg cagtccgagt 3000
ctaagaagaa tagaaggggc ggccgggagg atatcctgga aaaatggatc accacacgca 3060
gaaaagctga agaactggaa aaggacctga ggaaggcccg caagaccatc aagaagctgg 3120
aggatgaaaa tccatggctg ggaaacatca tcggcatcat cagaaagggc aaggacgggg 3180
aaggcgcccc acctgcaaag cggcctagaa ccgatcagat ggaaatcgat tctggcacag 3240
gcaagcggcc acacaagagt ggcttcaccg ataaggagag agaggatcac agaaggcgca 3300
aggccctgga gaacaagaag aagcaattaa gcagcggcgg caagaatctg tccagagaag 3360
aagaggagga gctgggcaga ctgacagtgg aggacgagga gcggagaagg cgcgtggcag 3420
gaccaaggac cggcgatgtg aacctgagcg gaggaggacc taggggagca ccaggaggcg 3480
gcttcgtgcc taggatggag ggagtgccag agtccccctt taccaggact ggcgagggcc 3540
tggacatcag gggaaatcag ggattcccat gggtgcggcc tagcccacca cagcagagac 3600
tgccactgct ggagtgtaca ccccagggca caaacctgag cacatccaat ccgctgggct 3660
tctttccaga tcatcaatta gatccagcct tcagggccaa ctccgccaat ccggattggg 3720
acttcaaccc gaataaggac acttggcccg acgcaaacaa ggtcggaggg caaaacctgt 3780
ctaccagcaa tccacttggc ttctttcctg accatcagct ggatcccgcc tttcgcgcca 3840
ataccgccaa tcctgactgg gacttcaatc ctaacaaaga cacctggccc gacgcaaaca 3900
aagtgggatg atgagaattc cgt                                         3923

<210> 29
<211> 1299
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 4 protein

<400> 29
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro
    210                 215                 220                 
Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn
225                 230                 235                 240 
Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro
                245                 250                 255     
Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu
            260                 265                 270         
Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr
        275                 280                 285             
Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp
    290                 295                 300                 
Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320 
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Arg Ser Glu
                325                 330                 335     
Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val
            340                 345                 350         
Asn Gly Arg Lys Lys Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala
        355                 360                 365             
Arg Lys Lys Ile Lys Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn
    370                 375                 380                 
Val Lys Gly Ile Leu Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro
385                 390                 395                 400 
Pro Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro
                405                 410                 415     
Arg Lys Arg Pro Leu Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp
            420                 425                 430         
His Arg Arg Arg Lys Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala
        435                 440                 445             
Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu
    450                 455                 460                 
Thr Arg Glu Asp Glu Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg
465                 470                 475                 480 
Leu Gly Val Asn Pro Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly
                485                 490                 495     
Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg
            500                 505                 510         
Thr Gly Glu Gly Leu Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp
        515                 520                 525             
Ile Leu Phe Pro Ser Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro
    530                 535                 540                 
Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp
545                 550                 555                 560 
His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp
                565                 570                 575     
Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
            580                 585                 590         
Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His
        595                 600                 605             
Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp
    610                 615                 620                 
Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly
625                 630                 635                 640 
Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu
                645                 650                 655     
Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg
            660                 665                 670         
Gly Thr Arg Glu Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys
        675                 680                 685             
Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys
    690                 695                 700                 
Lys Leu Glu Glu Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile
705                 710                 715                 720 
Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg
                725                 730                 735     
Thr Asp Gln Met Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys
            740                 745                 750         
Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala
        755                 760                 765             
Leu Glu Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser
    770                 775                 780                 
Lys Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu
785                 790                 795                 800 
Arg Lys Arg Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser
                805                 810                 815     
Arg Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met
            820                 825                 830         
Ala Gly Val Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp
        835                 840                 845             
Ile Arg Gly Thr Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln
    850                 855                 860                 
Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser
865                 870                 875                 880 
Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala
                885                 890                 895     
Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys
            900                 905                 910         
Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr
        915                 920                 925             
Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe
    930                 935                 940                 
Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp
945                 950                 955                 960 
Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe
                965                 970                 975     
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
            980                 985                 990         
Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly Arg Glu Asp Ile
        995                 1000                1005            
Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu Glu Leu Glu Lys
    1010                1015                1020                
Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu Glu Asp Glu Asn
1025                1030                1035               1040 
Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile Arg Lys Gly Lys Asp Gly
                1045                1050                1055    
Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Ile
            1060                1065                1070        
Asp Ser Gly Thr Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys
        1075                1080                1085            
Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys
    1090                1095                1100                
Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser Arg Glu Glu Glu Glu Glu
1105                1110                1115               1120 
Leu Gly Arg Leu Thr Val Glu Asp Glu Glu Arg Arg Arg Arg Val Ala
                1125                1130                1135    
Gly Pro Arg Thr Gly Asp Val Asn Leu Ser Gly Gly Gly Pro Arg Gly
            1140                1145                1150        
Ala Pro Gly Gly Gly Phe Val Pro Arg Met Glu Gly Val Pro Glu Ser
        1155                1160                1165            
Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Asn Gln Gly
    1170                1175                1180                
Phe Pro Trp Val Arg Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu
1185                1190                1195               1200 
Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly
                1205                1210                1215    
Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala
            1220                1225                1230        
Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala
        1235                1240                1245            
Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe
    1250                1255                1260                
Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn
1265                1270                1275               1280 
Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn
                1285                1290                1295    
Lys Val Gly
            


<210> 30
<211> 2625
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 5 wt

<400> 30
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcaga gccgcagcga aagcaaaaaa 660
aaccgcggcg gccgcgaaga agtgctggaa cagtgggtga acggccgcaa aaaactggaa 720
gaactggaac gcgaactgcg ccgcgcgcgc aaaaaaatta aaaaactgga agatgataac 780
ccgtggctgg gcaacgtgaa aggcattctg ggcaaaaaag ataaagatgg cgaaggcgcg 840
ccgccggcga aacgcgcgcg caccgatcag atggaaattg atagcggccc gcgcaaacgc 900
ccgctgcgcg gcggctttac cgatcgcgaa cgccaggatc atcgccgccg caaagcgctg 960
aaaaacaaaa aaaaacagct gagcgcgggc ggcaaaagcc tgagcaaaga agaagaagaa 1020
gaactgaaac gcctgacccg cgaagatgaa gaacgcaaaa aagaagaaca tggcccgagc 1080
cgcctgggcg tgaacccgag cgaaggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgagcatgc agggcattcc ggaaagccgc tttacccgca ccggcgaagg cctggatgtg 1200
cgcggcagcc gcggctttcc gcaggatatt ctgtttccga gcgatccgcc gtttagcccg 1260
cagagctgcc gcccgcaggg aagcggagct actaacttca gcctgctgaa gcaggctgga 1320
gacgtggagg agaaccctgg acctatgagc cagagcgaaa cccgccgcgg ccgccgcggc 1380
acccgcgaag aaaccctgga aaaatggatt accgcgcgca aaaaagcgga agaactggaa 1440
aaagatctgc gcaaaacccg caaaaccatt aaaaaactgg aagaagaaaa cccgtggctg 1500
ggcaacattg tgggcattat tcgcaaaggc aaagatggcg aaggcgcgcc gccggcgaaa 1560
cgcccgcgca ccgatcagat ggaagtggat agcggcccgg gcaaacgccc gcataaaagc 1620
ggctttaccg ataaagaacg cgaagatcat cgccgccgca aagcgctgga aaacaaaaaa 1680
aaacagctga gcgcgggcgg caaaattctg agcaaagaag aagaagaaga actgcgccgc 1740
ctgaccgatg aagatgaaga acgcaaacgc cgcgtggcgg gcccgcgcgt gggcgatgtg 1800
aacccgagcc gcggcggccc gcgcggcgcg ccgggcggcg gctttgtgcc gcagatggcg 1860
ggcgtgccgg aaagcccgtt tagccgcacc ggcgaaggcc tggatattcg cggcacccag 1920
ggctttccgt gggtgagccc gagcccgccg cagcagcgcc tgccgctgct ggaatgcacc 1980
ccgcagagcc agagcgaaag caaaaaaaac cgccgcggcg gccgcgaaga tattctggaa 2040
aaatggatta ccacccgccg caaagcggaa gaactggaaa aagatctgcg caaagcgcgc 2100
aaaaccatta aaaaactgga agatgaaaac ccgtggctgg gcaacattat tggcattatt 2160
cgcaaaggca aagatggcga aggcgcgccg ccggcgaaac gcccgcgcac cgatcagatg 2220
gaaattgata gcggcaccgg caaacgcccg cataaaagcg gctttaccga taaagaacgc 2280
gaagatcatc gccgccgcaa agcgctggaa aacaaaaaaa aacagctgag cagcggcggc 2340
aaaaacctga gccgcgaaga agaagaagaa ctgggccgcc tgaccgtgga agatgaagaa 2400
cgccgccgcc gcgtggcggg cccgcgcacc ggcgatgtga acctgagcgg cggcggcccg 2460
cgcggcgcgc cgggcggcgg ctttgtgccg cgcatggaag gcgtgccgga aagcccgttt 2520
acccgcaccg gcgaaggcct ggatattcgc ggcaaccagg gctttccgtg ggtgcgcccg 2580
agcccgccgc agcagcgcct gccgctgctg gaatgcaccc cgcag                 2625

<210> 31
<211> 2657
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 5 wt with restriction sites (HindIII /EcoRI)

<400> 31
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagagcc 660
gcagcgaaag caaaaaaaac cgcggcggcc gcgaagaagt gctggaacag tgggtgaacg 720
gccgcaaaaa actggaagaa ctggaacgcg aactgcgccg cgcgcgcaaa aaaattaaaa 780
aactggaaga tgataacccg tggctgggca acgtgaaagg cattctgggc aaaaaagata 840
aagatggcga aggcgcgccg ccggcgaaac gcgcgcgcac cgatcagatg gaaattgata 900
gcggcccgcg caaacgcccg ctgcgcggcg gctttaccga tcgcgaacgc caggatcatc 960
gccgccgcaa agcgctgaaa aacaaaaaaa aacagctgag cgcgggcggc aaaagcctga 1020
gcaaagaaga agaagaagaa ctgaaacgcc tgacccgcga agatgaagaa cgcaaaaaag 1080
aagaacatgg cccgagccgc ctgggcgtga acccgagcga aggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg agcatgcagg gcattccgga aagccgcttt acccgcaccg 1200
gcgaaggcct ggatgtgcgc ggcagccgcg gctttccgca ggatattctg tttccgagcg 1260
atccgccgtt tagcccgcag agctgccgcc cgcagggaag cggagctact aacttcagcc 1320
tgctgaagca ggctggagac gtggaggaga accctggacc tatgagccag agcgaaaccc 1380
gccgcggccg ccgcggcacc cgcgaagaaa ccctggaaaa atggattacc gcgcgcaaaa 1440
aagcggaaga actggaaaaa gatctgcgca aaacccgcaa aaccattaaa aaactggaag 1500
aagaaaaccc gtggctgggc aacattgtgg gcattattcg caaaggcaaa gatggcgaag 1560
gcgcgccgcc ggcgaaacgc ccgcgcaccg atcagatgga agtggatagc ggcccgggca 1620
aacgcccgca taaaagcggc tttaccgata aagaacgcga agatcatcgc cgccgcaaag 1680
cgctggaaaa caaaaaaaaa cagctgagcg cgggcggcaa aattctgagc aaagaagaag 1740
aagaagaact gcgccgcctg accgatgaag atgaagaacg caaacgccgc gtggcgggcc 1800
cgcgcgtggg cgatgtgaac ccgagccgcg gcggcccgcg cggcgcgccg ggcggcggct 1860
ttgtgccgca gatggcgggc gtgccggaaa gcccgtttag ccgcaccggc gaaggcctgg 1920
atattcgcgg cacccagggc tttccgtggg tgagcccgag cccgccgcag cagcgcctgc 1980
cgctgctgga atgcaccccg cagagccaga gcgaaagcaa aaaaaaccgc cgcggcggcc 2040
gcgaagatat tctggaaaaa tggattacca cccgccgcaa agcggaagaa ctggaaaaag 2100
atctgcgcaa agcgcgcaaa accattaaaa aactggaaga tgaaaacccg tggctgggca 2160
acattattgg cattattcgc aaaggcaaag atggcgaagg cgcgccgccg gcgaaacgcc 2220
cgcgcaccga tcagatggaa attgatagcg gcaccggcaa acgcccgcat aaaagcggct 2280
ttaccgataa agaacgcgaa gatcatcgcc gccgcaaagc gctggaaaac aaaaaaaaac 2340
agctgagcag cggcggcaaa aacctgagcc gcgaagaaga agaagaactg ggccgcctga 2400
ccgtggaaga tgaagaacgc cgccgccgcg tggcgggccc gcgcaccggc gatgtgaacc 2460
tgagcggcgg cggcccgcgc ggcgcgccgg gcggcggctt tgtgccgcgc atggaaggcg 2520
tgccggaaag cccgtttacc cgcaccggcg aaggcctgga tattcgcggc aaccagggct 2580
ttccgtgggt gcgcccgagc ccgccgcagc agcgcctgcc gctgctggaa tgcaccccgc 2640
agtgatgaga attccgt                                                2657

<210> 32
<211> 2628
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 5 codon optimized

<400> 32
gcctcacggt cagagtcaaa gaaaaatagg ggggggcggg aagaaatcct ggaacagtgg 60
gtcggagcac ggaaaaaact ggaagagctg gagagggacc tgcgcaagat caagaagaag 120
atcaagaagc tggaggagga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggatcggg agggagaggg agcaccacct gcaaagaggg ccagagccga ccagatggag 240
gtggatagcg gccctaggaa gcgcccattc agaggcgagt ttaccgacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagcggaagc agctgagctc cggcggcaag 360
tccctgtcta aggaggagga ggaggagctg agaaagctga cagaggagga cgagagaagg 420
gagcgccggg tggccggccc aagggtgggc ggcgtgaacc ccctggaggg aggaaccagg 480
ggagcacctg gaggaggctt cgtgccatct atgcagggcg tgcctgagag cccatttgcc 540
aggacaggag agggcctgga tgtgcgcggc aatcagggct tcccctggga catcctgttt 600
cctgccgatc cacccttcag cccacagtcc tgcaggcctc agagcagatc cgagtctaag 660
aagaacaggg gaggaagaga ggaggtgctg gagcagtggg tgaatggccg gaagaagctg 720
gaggagctgg agcgggagct gagaagggcc agaaagaaga tcaagaagct ggaagacgat 780
aatccttggc tgggcaatgt gaaaggcatc ctgggcaaga aggacaagga tggagaggga 840
gcacctccag caaagagggc aagaaccgac cagatggaga tcgatagcgg accaaggaag 900
cgccctctga gaggaggctt cacagaccgg gagagacagg atcaccgccg gagaaaggcc 960
ctgaagaaca agaagaagca gctgtccgcc ggaggcaaga gcctgtccaa agaagaggaa 1020
gaggagctga agaggctgac ccgcgaggac gaggagcgga agaaggagga gcacggccct 1080
tccagactgg gcgtgaatcc atctgaggga ggaccaaggg gagcaccagg cggcggcttc 1140
gtgccaagca tgcagggcat ccccgagtcc cggtttacca gaacaggaga gggcctggac 1200
gtgaggggct ctcgcggctt tcctcaggac atcctgttcc caagcgatcc ccctttttct 1260
ccacagagct gtcgccccca gggaagcgga gctactaact tcagcctgct gaagcaggct 1320
ggagacgtgg aggagaaccc tggacctatg tctcagagcg agacaaggag gggccggaga 1380
ggaaccaggg aggagacact ggagaagtgg atcacagcca gaaagaaggc cgaggagctg 1440
gagaaggacc tgcggaagac cagaaagaca atcaagaagc tggaagaaga aaatccatgg 1500
ctgggaaata tcgtgggcat catcaggaag ggcaaggacg gcgagggagc accaccagcc 1560
aagaggcctc gcactgatca gatggaggtg gattccggcc ctggcaagag gccacacaag 1620
tctggcttca cagacaagga gagggaggac cataggcgcc ggaaggccct ggaaaacaag 1680
aagaagcaat tatctgccgg cggcaagatc ctgagcaaag aggaagagga ggagctgaga 1740
aggctgaccg acgaggatga ggagaggaag aggagggtgg caggaccaag agtgggcgac 1800
gtgaatccta gcagaggcgg accaagaggc gccccaggcg ggggcttcgt gccacagatg 1860
gcaggagtgc cagagtcccc tttttctagg accggagagg gcctggatat caggggaaca 1920
cagggctttc catgggtgtc cccatctcct ccacagcaga ggctgccact gctggagtgc 1980
acccctcaga gccagtccga gtctaagaag aatagaaggg gcggccgcga ggacatcctg 2040
gagaagtgga tcaccacacg cagaaaagct gaagaactgg aaaaggacct gaggaaggcc 2100
cgcaaaacaa tcaagaagct ggaggatgag aacccttggc tgggcaatat catcggaatt 2160
atcaggaagg gcaaggatgg cgaaggcgcc ccacctgcaa agcggccaag gactgatcag 2220
atggaaatcg atagcggaac aggcaagcgg ccccacaagt ccggcttcac cgacaaggag 2280
agagaggatc acagaaggcg caaggccctg gagaacaaga agaagcaatt aagcagcggc 2340
ggcaagaatc tgtccagaga agaagaggag gagctgggca gactgaccgt ggaggacgag 2400
gagcggagaa ggcgcgtggc aggacctcgc acaggcgatg tgaacctgtc cggaggagga 2460
cctaggggag caccaggagg cggcttcgtg ccacgcatgg agggcgtgcc agagtctccc 2520
tttacccgca ccggagaggg cctggacatc aggggcaatc agggctttcc ctgggtccgc 2580
ccctcccccc ctcagcagag actgcccctg ctggaatgca caccacag              2628

<210> 33
<211> 2657
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 5 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 33
aagcttgcac catggcctca cggtcagagt caaagaaaaa tagggggggg cgggaagaaa 60
tcctggaaca gtgggtcgga gcacggaaaa aactggaaga gctggagagg gacctgcgca 120
agatcaagaa gaagatcaag aagctggagg aggagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat cgggagggag agggagcacc acctgcaaag agggccagag 240
ccgaccagat ggaggtggat agcggcccta ggaagcgccc attcagaggc gagtttaccg 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagcgg aagcagctga 360
gctccggcgg caagtccctg tctaaggagg aggaggagga gctgagaaag ctgacagagg 420
aggacgagag aagggagcgc cgggtggccg gcccaagggt gggcggcgtg aaccccctgg 480
agggaggaac caggggagca cctggaggag gcttcgtgcc atctatgcag ggcgtgcctg 540
agagcccatt tgccaggaca ggagagggcc tggatgtgcg cggcaatcag ggcttcccct 600
gggacatcct gtttcctgcc gatccaccct tcagcccaca gtcctgcagg cctcagagca 660
gatccgagtc taagaagaac aggggaggaa gagaggaggt gctggagcag tgggtgaatg 720
gccggaagaa gctggaggag ctggagcggg agctgagaag ggccagaaag aagatcaaga 780
agctggaaga cgataatcct tggctgggca atgtgaaagg catcctgggc aagaaggaca 840
aggatggaga gggagcacct ccagcaaaga gggcaagaac cgaccagatg gagatcgata 900
gcggaccaag gaagcgccct ctgagaggag gcttcacaga ccgggagaga caggatcacc 960
gccggagaaa ggccctgaag aacaagaaga agcagctgtc cgccggaggc aagagcctgt 1020
ccaaagaaga ggaagaggag ctgaagaggc tgacccgcga ggacgaggag cggaagaagg 1080
aggagcacgg cccttccaga ctgggcgtga atccatctga gggaggacca aggggagcac 1140
caggcggcgg cttcgtgcca agcatgcagg gcatccccga gtcccggttt accagaacag 1200
gagagggcct ggacgtgagg ggctctcgcg gctttcctca ggacatcctg ttcccaagcg 1260
atcccccttt ttctccacag agctgtcgcc cccagggaag cggagctact aacttcagcc 1320
tgctgaagca ggctggagac gtggaggaga accctggacc tatgtctcag agcgagacaa 1380
ggaggggccg gagaggaacc agggaggaga cactggagaa gtggatcaca gccagaaaga 1440
aggccgagga gctggagaag gacctgcgga agaccagaaa gacaatcaag aagctggaag 1500
aagaaaatcc atggctggga aatatcgtgg gcatcatcag gaagggcaag gacggcgagg 1560
gagcaccacc agccaagagg cctcgcactg atcagatgga ggtggattcc ggccctggca 1620
agaggccaca caagtctggc ttcacagaca aggagaggga ggaccatagg cgccggaagg 1680
ccctggaaaa caagaagaag caattatctg ccggcggcaa gatcctgagc aaagaggaag 1740
aggaggagct gagaaggctg accgacgagg atgaggagag gaagaggagg gtggcaggac 1800
caagagtggg cgacgtgaat cctagcagag gcggaccaag aggcgcccca ggcgggggct 1860
tcgtgccaca gatggcagga gtgccagagt cccctttttc taggaccgga gagggcctgg 1920
atatcagggg aacacagggc tttccatggg tgtccccatc tcctccacag cagaggctgc 1980
cactgctgga gtgcacccct cagagccagt ccgagtctaa gaagaataga aggggcggcc 2040
gcgaggacat cctggagaag tggatcacca cacgcagaaa agctgaagaa ctggaaaagg 2100
acctgaggaa ggcccgcaaa acaatcaaga agctggagga tgagaaccct tggctgggca 2160
atatcatcgg aattatcagg aagggcaagg atggcgaagg cgccccacct gcaaagcggc 2220
caaggactga tcagatggaa atcgatagcg gaacaggcaa gcggccccac aagtccggct 2280
tcaccgacaa ggagagagag gatcacagaa ggcgcaaggc cctggagaac aagaagaagc 2340
aattaagcag cggcggcaag aatctgtcca gagaagaaga ggaggagctg ggcagactga 2400
ccgtggagga cgaggagcgg agaaggcgcg tggcaggacc tcgcacaggc gatgtgaacc 2460
tgtccggagg aggacctagg ggagcaccag gaggcggctt cgtgccacgc atggagggcg 2520
tgccagagtc tccctttacc cgcaccggag agggcctgga catcaggggc aatcagggct 2580
ttccctgggt ccgcccctcc ccccctcagc agagactgcc cctgctggaa tgcacaccac 2640
agtgatgaga attccgt                                                2657

<210> 34
<211> 877
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 5 protein

<400> 34
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys
225                 230                 235                 240 
Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys
                245                 250                 255     
Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu
            260                 265                 270         
Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu
    290                 295                 300                 
Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu
                325                 330                 335     
Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu
            340                 345                 350         
Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro
        355                 360                 365             
Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser
    370                 375                 380                 
Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser
                405                 410                 415     
Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala
            420                 425                 430         
Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro
        435                 440                 445             
Gly Pro Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg
    450                 455                 460                 
Glu Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu
465                 470                 475                 480 
Leu Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu
                485                 490                 495     
Glu Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly
            500                 505                 510         
Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln
        515                 520                 525             
Met Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe
    530                 535                 540                 
Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn
545                 550                 555                 560 
Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu
                565                 570                 575     
Glu Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg
            580                 585                 590         
Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly
        595                 600                 605             
Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val
    610                 615                 620                 
Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly
625                 630                 635                 640 
Thr Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu
                645                 650                 655     
Pro Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn
            660                 665                 670         
Arg Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg
        675                 680                 685             
Arg Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr
    690                 695                 700                 
Ile Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly
705                 710                 715                 720 
Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg
                725                 730                 735     
Pro Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro
            740                 745                 750         
His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg
        755                 760                 765             
Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn
    770                 775                 780                 
Leu Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp
785                 790                 795                 800 
Glu Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn
                805                 810                 815     
Leu Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro
            820                 825                 830         
Arg Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly
        835                 840                 845             
Leu Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro
    850                 855                 860                 
Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln
865                 870                 875         


<210> 35
<211> 2763
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 6 wt

<400> 35
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcagg gaagcggagc tactaacttc 660
agcctgctga agcaggctgg agacgtggag gagaaccctg gacctatgag ccgcagcgaa 720
agcaaaaaaa accgcggcgg ccgcgaagaa gtgctggaac agtgggtgaa cggccgcaaa 780
aaactggaag aactggaacg cgaactgcgc cgcgcgcgca aaaaaattaa aaaactggaa 840
gatgataacc cgtggctggg caacgtgaaa ggcattctgg gcaaaaaaga taaagatggc 900
gaaggcgcgc cgccggcgaa acgcgcgcgc accgatcaga tggaaattga tagcggcccg 960
cgcaaacgcc cgctgcgcgg cggctttacc gatcgcgaac gccaggatca tcgccgccgc 1020
aaagcgctga aaaacaaaaa aaaacagctg agcgcgggcg gcaaaagcct gagcaaagaa 1080
gaagaagaag aactgaaacg cctgacccgc gaagatgaag aacgcaaaaa agaagaacat 1140
ggcccgagcc gcctgggcgt gaacccgagc gaaggcggcc cgcgcggcgc gccgggcggc 1200
ggctttgtgc cgagcatgca gggcattccg gaaagccgct ttacccgcac cggcgaaggc 1260
ctggatgtgc gcggcagccg cggctttccg caggatattc tgtttccgag cgatccgccg 1320
tttagcccgc agagctgccg cccgcaggga agcggagcta ctaacttcag cctgctgaag 1380
caggctggag acgtggagga gaaccctgga cctatgagcc agagcgaaac ccgccgcggc 1440
cgccgcggca cccgcgaaga aaccctggaa aaatggatta ccgcgcgcaa aaaagcggaa 1500
gaactggaaa aagatctgcg caaaacccgc aaaaccatta aaaaactgga agaagaaaac 1560
ccgtggctgg gcaacattgt gggcattatt cgcaaaggca aagatggcga aggcgcgccg 1620
ccggcgaaac gcccgcgcac cgatcagatg gaagtggata gcggcccggg caaacgcccg 1680
cataaaagcg gctttaccga taaagaacgc gaagatcatc gccgccgcaa agcgctggaa 1740
aacaaaaaaa aacagctgag cgcgggcggc aaaattctga gcaaagaaga agaagaagaa 1800
ctgcgccgcc tgaccgatga agatgaagaa cgcaaacgcc gcgtggcggg cccgcgcgtg 1860
ggcgatgtga acccgagccg cggcggcccg cgcggcgcgc cgggcggcgg ctttgtgccg 1920
cagatggcgg gcgtgccgga aagcccgttt agccgcaccg gcgaaggcct ggatattcgc 1980
ggcacccagg gctttccgtg ggtgagcccg agcccgccgc agcagcgcct gccgctgctg 2040
gaatgcaccc cgcagggaag cggagctact aacttcagcc tgctgaagca ggctggagac 2100
gtggaggaga accctggacc tatgagccag agcgaaagca aaaaaaaccg ccgcggcggc 2160
cgcgaagata ttctggaaaa atggattacc acccgccgca aagcggaaga actggaaaaa 2220
gatctgcgca aagcgcgcaa aaccattaaa aaactggaag atgaaaaccc gtggctgggc 2280
aacattattg gcattattcg caaaggcaaa gatggcgaag gcgcgccgcc ggcgaaacgc 2340
ccgcgcaccg atcagatgga aattgatagc ggcaccggca aacgcccgca taaaagcggc 2400
tttaccgata aagaacgcga agatcatcgc cgccgcaaag cgctggaaaa caaaaaaaaa 2460
cagctgagca gcggcggcaa aaacctgagc cgcgaagaag aagaagaact gggccgcctg 2520
accgtggaag atgaagaacg ccgccgccgc gtggcgggcc cgcgcaccgg cgatgtgaac 2580
ctgagcggcg gcggcccgcg cggcgcgccg ggcggcggct ttgtgccgcg catggaaggc 2640
gtgccggaaa gcccgtttac ccgcaccggc gaaggcctgg atattcgcgg caaccagggc 2700
tttccgtggg tgcgcccgag cccgccgcag cagcgcctgc cgctgctgga atgcaccccg 2760
cag                                                               2763

<210> 36
<211> 2795
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 6 wt with restriction sites (HindIII /EcoRI)

<400> 36
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagggaa 660
gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag aaccctggac 720
ctatgagccg cagcgaaagc aaaaaaaacc gcggcggccg cgaagaagtg ctggaacagt 780
gggtgaacgg ccgcaaaaaa ctggaagaac tggaacgcga actgcgccgc gcgcgcaaaa 840
aaattaaaaa actggaagat gataacccgt ggctgggcaa cgtgaaaggc attctgggca 900
aaaaagataa agatggcgaa ggcgcgccgc cggcgaaacg cgcgcgcacc gatcagatgg 960
aaattgatag cggcccgcgc aaacgcccgc tgcgcggcgg ctttaccgat cgcgaacgcc 1020
aggatcatcg ccgccgcaaa gcgctgaaaa acaaaaaaaa acagctgagc gcgggcggca 1080
aaagcctgag caaagaagaa gaagaagaac tgaaacgcct gacccgcgaa gatgaagaac 1140
gcaaaaaaga agaacatggc ccgagccgcc tgggcgtgaa cccgagcgaa ggcggcccgc 1200
gcggcgcgcc gggcggcggc tttgtgccga gcatgcaggg cattccggaa agccgcttta 1260
cccgcaccgg cgaaggcctg gatgtgcgcg gcagccgcgg ctttccgcag gatattctgt 1320
ttccgagcga tccgccgttt agcccgcaga gctgccgccc gcagggaagc ggagctacta 1380
acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct atgagccaga 1440
gcgaaacccg ccgcggccgc cgcggcaccc gcgaagaaac cctggaaaaa tggattaccg 1500
cgcgcaaaaa agcggaagaa ctggaaaaag atctgcgcaa aacccgcaaa accattaaaa 1560
aactggaaga agaaaacccg tggctgggca acattgtggg cattattcgc aaaggcaaag 1620
atggcgaagg cgcgccgccg gcgaaacgcc cgcgcaccga tcagatggaa gtggatagcg 1680
gcccgggcaa acgcccgcat aaaagcggct ttaccgataa agaacgcgaa gatcatcgcc 1740
gccgcaaagc gctggaaaac aaaaaaaaac agctgagcgc gggcggcaaa attctgagca 1800
aagaagaaga agaagaactg cgccgcctga ccgatgaaga tgaagaacgc aaacgccgcg 1860
tggcgggccc gcgcgtgggc gatgtgaacc cgagccgcgg cggcccgcgc ggcgcgccgg 1920
gcggcggctt tgtgccgcag atggcgggcg tgccggaaag cccgtttagc cgcaccggcg 1980
aaggcctgga tattcgcggc acccagggct ttccgtgggt gagcccgagc ccgccgcagc 2040
agcgcctgcc gctgctggaa tgcaccccgc agggaagcgg agctactaac ttcagcctgc 2100
tgaagcaggc tggagacgtg gaggagaacc ctggacctat gagccagagc gaaagcaaaa 2160
aaaaccgccg cggcggccgc gaagatattc tggaaaaatg gattaccacc cgccgcaaag 2220
cggaagaact ggaaaaagat ctgcgcaaag cgcgcaaaac cattaaaaaa ctggaagatg 2280
aaaacccgtg gctgggcaac attattggca ttattcgcaa aggcaaagat ggcgaaggcg 2340
cgccgccggc gaaacgcccg cgcaccgatc agatggaaat tgatagcggc accggcaaac 2400
gcccgcataa aagcggcttt accgataaag aacgcgaaga tcatcgccgc cgcaaagcgc 2460
tggaaaacaa aaaaaaacag ctgagcagcg gcggcaaaaa cctgagccgc gaagaagaag 2520
aagaactggg ccgcctgacc gtggaagatg aagaacgccg ccgccgcgtg gcgggcccgc 2580
gcaccggcga tgtgaacctg agcggcggcg gcccgcgcgg cgcgccgggc ggcggctttg 2640
tgccgcgcat ggaaggcgtg ccggaaagcc cgtttacccg caccggcgaa ggcctggata 2700
ttcgcggcaa ccagggcttt ccgtgggtgc gcccgagccc gccgcagcag cgcctgccgc 2760
tgctggaatg caccccgcag tgatgagaat tccgt                            2795

<210> 37
<211> 2766
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 6 codon optimized

<400> 37
gcctcacggt cagagtcaaa gaagaacaga ggcggaagag aagaaatcct ggagcagtgg 60
gtcggagcac ggaaaaagct ggaagaactg gagagggacc tgcgcaagat caagaagaag 120
atcaagaagc tggaggagga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggataggg agggagaggg agcaccacct gcaaagaggg ccagagccga ccagatggag 240
gtggatagcg gaccaaggaa gcgccccttc cgcggagagt ttaccgacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagaggaagc agctgagctc cggcggcaag 360
tccctgtcta aggaggagga ggaggagctg cgcaagctga cagaggagga cgagagaagg 420
gagaggaggg tggcaggacc aagggtggga ggagtgaatc ctctggaggg aggaaccaga 480
ggagcaccag gaggaggctt cgtgccaagc atgcagggag tgccagagtc cccctttgcc 540
aggacaggag agggcctgga cgtgagaggc aaccagggct tcccttggga catcctgttt 600
ccagccgatc cacccttcag ccctcagtcc tgcaggccac agggaagcgg agctactaac 660
ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc ctggacctat gagccggtcc 720
gagtctaaga agaatagggg aggaagagag gaggtgctgg agcagtgggt gaacggcaga 780
aagaagctgg aggagctgga gagggagctg agaagggccc gcaagaagat caagaagctg 840
gaagacgata atccttggct gggcaatgtg aaaggcatcc tgggcaagaa ggacaaggat 900
ggagagggag cacctccagc aaagagggca agaaccgacc agatggagat cgatagcgga 960
cctaggaagc gcccactgag gggaggcttt acagaccggg agagacagga tcaccgccgg 1020
agaaaggccc tgaagaacaa gaagaagcag ctgtccgccg gaggcaagag cctgtccaaa 1080
gaagaggaag aggagctgaa gaggctgacc cgcgaggacg aggagaggaa gaaggaggag 1140
cacggaccat ctaggctggg agtgaatccc agcgagggag gaccaagggg agcacctgga 1200
ggaggcttcg tgccctccat gcagggcatc cctgagtctc ggtttaccag aaccggcgag 1260
ggcctggacg tgaggggcag ccgcggcttt ccacaggaca tcctgttccc ctccgatccc 1320
cctttttctc cccagagctg tcgccctcaa ggaagcggag ctactaactt cagcctgctg 1380
aagcaggctg gagacgtgga ggagaaccct ggacctatgt ctcagagcga gacaaggagg 1440
ggccggagag gaaccaggga ggagacactg gagaagtgga tcacagcccg caagaaggcc 1500
gaggagctgg agaaggacct gcggaagacc agaaagacaa tcaagaagct ggaagaagag 1560
aacccttggc tgggcaatat cgtgggcatc atcaggaagg gcaaggacgg cgagggagca 1620
ccaccagcca agaggccacg cactgatcag atggaggtgg attctggacc aggcaagcgg 1680
ccccacaaga gcggcttcac agacaaggag agagaggacc ataggcgccg gaaggccctg 1740
gaaaacaaga agaagcaatt aagcgccggc ggcaagatcc tgtccaaaga ggaagaggag 1800
gagctgagaa ggctgaccga cgaggatgag gagaggaaaa gaagggtggc aggacctagg 1860
gtgggcgacg tgaatccaag caggggagga cctagaggag caccaggagg cggcttcgtg 1920
ccacagatgg caggagtgcc tgagtcccca ttttctcgga ccggcgaggg cctggatatc 1980
agaggcacac agggcttccc ctgggtgtcc ccttctcctc cacagcagcg gctgcctctg 2040
ctggagtgca cccctcaggg aagcggagct actaacttca gcctgctgaa gcaggctgga 2100
gacgtggagg agaaccctgg acctatgtcg cagagcgaat ctaagaagaa tagaaggggc 2160
ggcagagagg atatcctgga gaagtggatc accacacgca gaaaagctga agaactggaa 2220
aaggacctga ggaaggcccg caagaccatc aagaagctgg aggatgaaaa tccatggctg 2280
ggaaatatca tcggcatcat ccggaagggc aaggacgggg aaggcgcccc acctgcaaag 2340
cggcccagga ctgatcagat ggaaatcgat tccggcacag gcaagaggcc tcacaagtct 2400
ggcttcacag ataaagagcg cgaggatcac agaaggcgca aggccctgga gaacaagaag 2460
aagcaattat ctagcggcgg caagaatctg tccagagaag aagaggagga gctgggccgc 2520
ctgaccgtgg aggacgagga gcggagaagg cgcgtggcag gaccaagaac aggcgatgtg 2580
aacctgtctg gaggcggccc aaggggcgcc cccggcggag gcttcgtgcc aagaatggaa 2640
ggcgtgccag agtccccttt tacccggaca ggggaaggcc tggacattag aggcaatcag 2700
ggctttccct gggtgcgacc aagcccccct cagcagcgac tgcctctgct ggagtgtacc 2760
cctcag                                                            2766

<210> 38
<211> 2795
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 6 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 38
aagcttgcac catggcctca cggtcagagt caaagaagaa cagaggcgga agagaagaaa 60
tcctggagca gtgggtcgga gcacggaaaa agctggaaga actggagagg gacctgcgca 120
agatcaagaa gaagatcaag aagctggagg aggagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat agggagggag agggagcacc acctgcaaag agggccagag 240
ccgaccagat ggaggtggat agcggaccaa ggaagcgccc cttccgcgga gagtttaccg 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagagg aagcagctga 360
gctccggcgg caagtccctg tctaaggagg aggaggagga gctgcgcaag ctgacagagg 420
aggacgagag aagggagagg agggtggcag gaccaagggt gggaggagtg aatcctctgg 480
agggaggaac cagaggagca ccaggaggag gcttcgtgcc aagcatgcag ggagtgccag 540
agtccccctt tgccaggaca ggagagggcc tggacgtgag aggcaaccag ggcttccctt 600
gggacatcct gtttccagcc gatccaccct tcagccctca gtcctgcagg ccacagggaa 660
gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag aaccctggac 720
ctatgagccg gtccgagtct aagaagaata ggggaggaag agaggaggtg ctggagcagt 780
gggtgaacgg cagaaagaag ctggaggagc tggagaggga gctgagaagg gcccgcaaga 840
agatcaagaa gctggaagac gataatcctt ggctgggcaa tgtgaaaggc atcctgggca 900
agaaggacaa ggatggagag ggagcacctc cagcaaagag ggcaagaacc gaccagatgg 960
agatcgatag cggacctagg aagcgcccac tgaggggagg ctttacagac cgggagagac 1020
aggatcaccg ccggagaaag gccctgaaga acaagaagaa gcagctgtcc gccggaggca 1080
agagcctgtc caaagaagag gaagaggagc tgaagaggct gacccgcgag gacgaggaga 1140
ggaagaagga ggagcacgga ccatctaggc tgggagtgaa tcccagcgag ggaggaccaa 1200
ggggagcacc tggaggaggc ttcgtgccct ccatgcaggg catccctgag tctcggttta 1260
ccagaaccgg cgagggcctg gacgtgaggg gcagccgcgg ctttccacag gacatcctgt 1320
tcccctccga tccccctttt tctccccaga gctgtcgccc tcaaggaagc ggagctacta 1380
acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct atgtctcaga 1440
gcgagacaag gaggggccgg agaggaacca gggaggagac actggagaag tggatcacag 1500
cccgcaagaa ggccgaggag ctggagaagg acctgcggaa gaccagaaag acaatcaaga 1560
agctggaaga agagaaccct tggctgggca atatcgtggg catcatcagg aagggcaagg 1620
acggcgaggg agcaccacca gccaagaggc cacgcactga tcagatggag gtggattctg 1680
gaccaggcaa gcggccccac aagagcggct tcacagacaa ggagagagag gaccataggc 1740
gccggaaggc cctggaaaac aagaagaagc aattaagcgc cggcggcaag atcctgtcca 1800
aagaggaaga ggaggagctg agaaggctga ccgacgagga tgaggagagg aaaagaaggg 1860
tggcaggacc tagggtgggc gacgtgaatc caagcagggg aggacctaga ggagcaccag 1920
gaggcggctt cgtgccacag atggcaggag tgcctgagtc cccattttct cggaccggcg 1980
agggcctgga tatcagaggc acacagggct tcccctgggt gtccccttct cctccacagc 2040
agcggctgcc tctgctggag tgcacccctc agggaagcgg agctactaac ttcagcctgc 2100
tgaagcaggc tggagacgtg gaggagaacc ctggacctat gtcgcagagc gaatctaaga 2160
agaatagaag gggcggcaga gaggatatcc tggagaagtg gatcaccaca cgcagaaaag 2220
ctgaagaact ggaaaaggac ctgaggaagg cccgcaagac catcaagaag ctggaggatg 2280
aaaatccatg gctgggaaat atcatcggca tcatccggaa gggcaaggac ggggaaggcg 2340
ccccacctgc aaagcggccc aggactgatc agatggaaat cgattccggc acaggcaaga 2400
ggcctcacaa gtctggcttc acagataaag agcgcgagga tcacagaagg cgcaaggccc 2460
tggagaacaa gaagaagcaa ttatctagcg gcggcaagaa tctgtccaga gaagaagagg 2520
aggagctggg ccgcctgacc gtggaggacg aggagcggag aaggcgcgtg gcaggaccaa 2580
gaacaggcga tgtgaacctg tctggaggcg gcccaagggg cgcccccggc ggaggcttcg 2640
tgccaagaat ggaaggcgtg ccagagtccc cttttacccg gacaggggaa ggcctggaca 2700
ttagaggcaa tcagggcttt ccctgggtgc gaccaagccc ccctcagcag cgactgcctc 2760
tgctggagtg tacccctcag tgatgagaat tccgt                            2795

<210> 39
<211> 923
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 6 protein

<400> 39
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu
    210                 215                 220                 
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Arg
225                 230                 235                 240 
Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Val Leu Glu Gln
                245                 250                 255     
Trp Val Asn Gly Arg Lys Lys Leu Glu Glu Leu Glu Arg Glu Leu Arg
            260                 265                 270         
Arg Ala Arg Lys Lys Ile Lys Lys Leu Glu Asp Asp Asn Pro Trp Leu
        275                 280                 285             
Gly Asn Val Lys Gly Ile Leu Gly Lys Lys Asp Lys Asp Gly Glu Gly
    290                 295                 300                 
Ala Pro Pro Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile Asp Ser
305                 310                 315                 320 
Gly Pro Arg Lys Arg Pro Leu Arg Gly Gly Phe Thr Asp Arg Glu Arg
                325                 330                 335     
Gln Asp His Arg Arg Arg Lys Ala Leu Lys Asn Lys Lys Lys Gln Leu
            340                 345                 350         
Ser Ala Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu Leu Lys
        355                 360                 365             
Arg Leu Thr Arg Glu Asp Glu Glu Arg Lys Lys Glu Glu His Gly Pro
    370                 375                 380                 
Ser Arg Leu Gly Val Asn Pro Ser Glu Gly Gly Pro Arg Gly Ala Pro
385                 390                 395                 400 
Gly Gly Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu Ser Arg Phe
                405                 410                 415     
Thr Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Ser Arg Gly Phe Pro
            420                 425                 430         
Gln Asp Ile Leu Phe Pro Ser Asp Pro Pro Phe Ser Pro Gln Ser Cys
        435                 440                 445             
Arg Pro Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala
    450                 455                 460                 
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Thr Arg
465                 470                 475                 480 
Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu Glu Lys Trp Ile Thr
                485                 490                 495     
Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Thr Arg
            500                 505                 510         
Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro Trp Leu Gly Asn Ile
        515                 520                 525             
Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala
    530                 535                 540                 
Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp Ser Gly Pro Gly Lys
545                 550                 555                 560 
Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg
                565                 570                 575     
Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly
            580                 585                 590         
Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Asp
        595                 600                 605             
Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly Pro Arg Val Gly Asp
    610                 615                 620                 
Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe
625                 630                 635                 640 
Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro Phe Ser Arg Thr Gly
                645                 650                 655     
Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe Pro Trp Val Ser Pro
            660                 665                 670         
Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly
        675                 680                 685             
Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu
    690                 695                 700                 
Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg
705                 710                 715                 720 
Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys
                725                 730                 735     
Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys
            740                 745                 750         
Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile
        755                 760                 765             
Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg
    770                 775                 780                 
Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys
785                 790                 795                 800 
Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala
                805                 810                 815     
Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser
            820                 825                 830         
Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu
        835                 840                 845             
Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser
    850                 855                 860                 
Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met
865                 870                 875                 880 
Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp
                885                 890                 895     
Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln
            900                 905                 910         
Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln
        915                 920             


<210> 40
<211> 1560
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 7 wt

<400> 40
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcaga gccgcagcga aagcaaaaaa 660
aaccgcggcg gccgcgaaga agtgctggaa cagtgggtga acggccgcaa aaaactggaa 720
gaactggaac gcgaactgcg ccgcgcgcgc aaaaaaatta aaaaactgga agatgataac 780
ccgtggctgg gcaacgtgaa aggcattctg ggcaaaaaag ataaagatgg cgaaggcgcg 840
ccgccggcga aacgcgcgcg caccgatcag atggaaattg atagcggccc gcgcaaacgc 900
ccgctgcgcg gcggctttac cgatcgcgaa cgccaggatc atcgccgccg caaagcgctg 960
aaaaacaaaa aaaaacagct gagcgcgggc ggcaaaagcc tgagcaaaga agaagaagaa 1020
gaactgaaac gcctgacccg cgaagatgaa gaacgcaaaa aagaagaaca tggcccgagc 1080
cgcctgggcg tgaacccgag cgaaggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgagcatgc agggcattcc ggaaagccgc tttacccgca ccggcgaagg cctggatgtg 1200
cgcggcagcc gcggctttcc gcaggatatt ctgtttccga gcgatccgcc gtttagcccg 1260
cagagctgcc gcccgcaggg caccaacctg agcaccagca acccgctggg cttttttccg 1320
gatcatcagc tggatccggc gtttcgcgcg aacagcgcga acccggattg ggattttaac 1380
ccgaacaaag atacctggcc ggatgcgaac aaagtgggcg gccagaacct gagcaccagc 1440
aacccgctgg gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacaccgcg 1500
aacccggatt gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc 1560


<210> 41
<211> 1592
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 7 wt with restriction sites (HindIII /EcoRI)

<400> 41
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagagcc 660
gcagcgaaag caaaaaaaac cgcggcggcc gcgaagaagt gctggaacag tgggtgaacg 720
gccgcaaaaa actggaagaa ctggaacgcg aactgcgccg cgcgcgcaaa aaaattaaaa 780
aactggaaga tgataacccg tggctgggca acgtgaaagg cattctgggc aaaaaagata 840
aagatggcga aggcgcgccg ccggcgaaac gcgcgcgcac cgatcagatg gaaattgata 900
gcggcccgcg caaacgcccg ctgcgcggcg gctttaccga tcgcgaacgc caggatcatc 960
gccgccgcaa agcgctgaaa aacaaaaaaa aacagctgag cgcgggcggc aaaagcctga 1020
gcaaagaaga agaagaagaa ctgaaacgcc tgacccgcga agatgaagaa cgcaaaaaag 1080
aagaacatgg cccgagccgc ctgggcgtga acccgagcga aggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg agcatgcagg gcattccgga aagccgcttt acccgcaccg 1200
gcgaaggcct ggatgtgcgc ggcagccgcg gctttccgca ggatattctg tttccgagcg 1260
atccgccgtt tagcccgcag agctgccgcc cgcagggcac caacctgagc accagcaacc 1320
cgctgggctt ttttccggat catcagctgg atccggcgtt tcgcgcgaac agcgcgaacc 1380
cggattggga ttttaacccg aacaaagata cctggccgga tgcgaacaaa gtgggcggcc 1440
agaacctgag caccagcaac ccgctgggct tttttccgga tcatcagctg gatccggcgt 1500
ttcgcgcgaa caccgcgaac ccggattggg attttaaccc gaacaaagat acctggccgg 1560
atgcgaacaa agtgggctga tgagaattcc gt                               1592

<210> 42
<211> 1563
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 7 codon optimized

<400> 42
gcctcacggt ctgagtcaaa gaagaatcgg gggggaagag aagaaatcct ggaacagtgg 60
gtcggcgcac ggaaaaaact ggaagaactg gagcgggacc tgagaaagat caagaagaag 120
atcaagaagc tggaggaaga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggatcggg agggcgaggg agcaccacct gcaaagaggg caagggcaga ccagatggag 240
gtggattccg gacctaggaa gcggcccttc cggggagagt ttaccgacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagcggaagc agctgagctc cggcggcaag 360
tctctgagca aggaggagga ggaggagctg agaaagctga cagaggagga cgagagaagg 420
gagcgccggg tggccggccc aagggtgggc ggcgtgaacc ccctggaggg aggaaccagg 480
ggagcaccag gaggaggctt cgtgccttct atgcagggcg tgccagagag cccctttgcc 540
aggacaggag agggcctgga tgtgcgcggc aatcagggct tcccatggga catcctgttt 600
cccgccgatc cacccttctc ccctcagtct tgcaggccac agtcccgctc tgagagcaag 660
aagaacaggg gaggaaggga ggaggtgctg gagcagtggg tgaatggcag gaagaagctg 720
gaggagctgg agcgggagct gagaagggcc agaaagaaga tcaagaagct ggaagacgat 780
aatccttggc tgggcaatgt gaaaggcatc ctgggcaaga aggacaagga tggagaggga 840
gcacctccag caaagagggc acgcaccgac cagatggaga tcgattccgg accaaggaag 900
cggcccctga ggggaggctt cacagacagg gagcgccagg atcaccgccg gagaaaggcc 960
ctgaagaaca agaagaagca gctgtctgcc ggcggcaagt ccctgtctaa agaagaggag 1020
gaggagctga agcggctgac cagagaggac gaggagcgga agaaggagga gcacggccct 1080
tccagactgg gcgtgaatcc atctgaggga ggaccaagag gcgcccctgg cggaggcttc 1140
gtgcctagca tgcagggcat cccagagtcc aggtttacca gaaccggaga gggcctggac 1200
gtgcggggct ctagaggctt tccccaggac atcctgttcc ctagcgatcc cccttttagc 1260
ccccagtcct gtaggcctca gggcaccaac ctgagcacat ccaatccact gggcttcttt 1320
ccagaccacc agctggatcc agccttccgc gccaacagcg ccaatccaga ctgggacttc 1380
aaccccaata aggacacctg gcctgatgcc aacaaggtcg gcggccagaa cctgtctaca 1440
agcaatcctc tgggcttctt tcctgatcac cagctggatc ctgcctttcg ggccaataca 1500
gccaaccctg actgggactt caatcctaac aaagacactt ggcccgatgc taataaggtc 1560
ggc                                                               1563

<210> 43
<211> 1592
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 7 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 43
aagcttgcac catggcctca cggtctgagt caaagaagaa tcggggggga agagaagaaa 60
tcctggaaca gtgggtcggc gcacggaaaa aactggaaga actggagcgg gacctgagaa 120
agatcaagaa gaagatcaag aagctggagg aagagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat cgggagggcg agggagcacc acctgcaaag agggcaaggg 240
cagaccagat ggaggtggat tccggaccta ggaagcggcc cttccgggga gagtttaccg 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagcgg aagcagctga 360
gctccggcgg caagtctctg agcaaggagg aggaggagga gctgagaaag ctgacagagg 420
aggacgagag aagggagcgc cgggtggccg gcccaagggt gggcggcgtg aaccccctgg 480
agggaggaac caggggagca ccaggaggag gcttcgtgcc ttctatgcag ggcgtgccag 540
agagcccctt tgccaggaca ggagagggcc tggatgtgcg cggcaatcag ggcttcccat 600
gggacatcct gtttcccgcc gatccaccct tctcccctca gtcttgcagg ccacagtccc 660
gctctgagag caagaagaac aggggaggaa gggaggaggt gctggagcag tgggtgaatg 720
gcaggaagaa gctggaggag ctggagcggg agctgagaag ggccagaaag aagatcaaga 780
agctggaaga cgataatcct tggctgggca atgtgaaagg catcctgggc aagaaggaca 840
aggatggaga gggagcacct ccagcaaaga gggcacgcac cgaccagatg gagatcgatt 900
ccggaccaag gaagcggccc ctgaggggag gcttcacaga cagggagcgc caggatcacc 960
gccggagaaa ggccctgaag aacaagaaga agcagctgtc tgccggcggc aagtccctgt 1020
ctaaagaaga ggaggaggag ctgaagcggc tgaccagaga ggacgaggag cggaagaagg 1080
aggagcacgg cccttccaga ctgggcgtga atccatctga gggaggacca agaggcgccc 1140
ctggcggagg cttcgtgcct agcatgcagg gcatcccaga gtccaggttt accagaaccg 1200
gagagggcct ggacgtgcgg ggctctagag gctttcccca ggacatcctg ttccctagcg 1260
atcccccttt tagcccccag tcctgtaggc ctcagggcac caacctgagc acatccaatc 1320
cactgggctt ctttccagac caccagctgg atccagcctt ccgcgccaac agcgccaatc 1380
cagactggga cttcaacccc aataaggaca cctggcctga tgccaacaag gtcggcggcc 1440
agaacctgtc tacaagcaat cctctgggct tctttcctga tcaccagctg gatcctgcct 1500
ttcgggccaa tacagccaac cctgactggg acttcaatcc taacaaagac acttggcccg 1560
atgctaataa ggtcggctga tgagaattcc gt                               1592

<210> 44
<211> 522
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 7 protein

<400> 44
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys
225                 230                 235                 240 
Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys
                245                 250                 255     
Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu
            260                 265                 270         
Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu
    290                 295                 300                 
Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu
                325                 330                 335     
Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu
            340                 345                 350         
Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro
        355                 360                 365             
Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser
    370                 375                 380                 
Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser
                405                 410                 415     
Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu
            420                 425                 430         
Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro
        435                 440                 445             
Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn
    450                 455                 460                 
Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser
465                 470                 475                 480 
Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala
                485                 490                 495     
Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys
            500                 505                 510         
Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
        515                 520         


<210> 45
<211> 1560
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 8 wt

<400> 45
agccagagcg aaacccgccg cggccgccgc ggcacccgcg aagaaaccct ggaaaaatgg 60
attaccgcgc gcaaaaaagc ggaagaactg gaaaaagatc tgcgcaaaac ccgcaaaacc 120
attaaaaaac tggaagaaga aaacccgtgg ctgggcaaca ttgtgggcat tattcgcaaa 180
ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaagtg 240
gatagcggcc cgggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat 300
catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcgcggg cggcaaaatt 360
ctgagcaaag aagaagaaga agaactgcgc cgcctgaccg atgaagatga agaacgcaaa 420
cgccgcgtgg cgggcccgcg cgtgggcgat gtgaacccga gccgcggcgg cccgcgcggc 480
gcgccgggcg gcggctttgt gccgcagatg gcgggcgtgc cggaaagccc gtttagccgc 540
accggcgaag gcctggatat tcgcggcacc cagggctttc cgtgggtgag cccgagcccg 600
ccgcagcagc gcctgccgct gctggaatgc accccgcaga gccagagcga aagcaaaaaa 660
aaccgccgcg gcggccgcga agatattctg gaaaaatgga ttaccacccg ccgcaaagcg 720
gaagaactgg aaaaagatct gcgcaaagcg cgcaaaacca ttaaaaaact ggaagatgaa 780
aacccgtggc tgggcaacat tattggcatt attcgcaaag gcaaagatgg cgaaggcgcg 840
ccgccggcga aacgcccgcg caccgatcag atggaaattg atagcggcac cggcaaacgc 900
ccgcataaaa gcggctttac cgataaagaa cgcgaagatc atcgccgccg caaagcgctg 960
gaaaacaaaa aaaaacagct gagcagcggc ggcaaaaacc tgagccgcga agaagaagaa 1020
gaactgggcc gcctgaccgt ggaagatgaa gaacgccgcc gccgcgtggc gggcccgcgc 1080
accggcgatg tgaacctgag cggcggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgcgcatgg aaggcgtgcc ggaaagcccg tttacccgca ccggcgaagg cctggatatt 1200
cgcggcaacc agggctttcc gtgggtgcgc ccgagcccgc cgcagcagcg cctgccgctg 1260
ctggaatgca ccccgcaggg caccaacctg agcaccagca acccgctggg cttttttccg 1320
gatcatcagc tggatccggc gtttcgcgcg aacagcgcga acccggattg ggattttaac 1380
ccgaacaaag atacctggcc ggatgcgaac aaagtgggcg gccagaacct gagcaccagc 1440
aacccgctgg gcttttttcc ggatcatcag ctggatccgg cgtttcgcgc gaacaccgcg 1500
aacccggatt gggattttaa cccgaacaaa gatacctggc cggatgcgaa caaagtgggc 1560


<210> 46
<211> 1592
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 8 wt with restriction sites (HindIII /EcoRI)

<400> 46
aagcttgcac catggccagc cagagcgaaa cccgccgcgg ccgccgcggc acccgcgaag 60
aaaccctgga aaaatggatt accgcgcgca aaaaagcgga agaactggaa aaagatctgc 120
gcaaaacccg caaaaccatt aaaaaactgg aagaagaaaa cccgtggctg ggcaacattg 180
tgggcattat tcgcaaaggc aaagatggcg aaggcgcgcc gccggcgaaa cgcccgcgca 240
ccgatcagat ggaagtggat agcggcccgg gcaaacgccc gcataaaagc ggctttaccg 300
ataaagaacg cgaagatcat cgccgccgca aagcgctgga aaacaaaaaa aaacagctga 360
gcgcgggcgg caaaattctg agcaaagaag aagaagaaga actgcgccgc ctgaccgatg 420
aagatgaaga acgcaaacgc cgcgtggcgg gcccgcgcgt gggcgatgtg aacccgagcc 480
gcggcggccc gcgcggcgcg ccgggcggcg gctttgtgcc gcagatggcg ggcgtgccgg 540
aaagcccgtt tagccgcacc ggcgaaggcc tggatattcg cggcacccag ggctttccgt 600
gggtgagccc gagcccgccg cagcagcgcc tgccgctgct ggaatgcacc ccgcagagcc 660
agagcgaaag caaaaaaaac cgccgcggcg gccgcgaaga tattctggaa aaatggatta 720
ccacccgccg caaagcggaa gaactggaaa aagatctgcg caaagcgcgc aaaaccatta 780
aaaaactgga agatgaaaac ccgtggctgg gcaacattat tggcattatt cgcaaaggca 840
aagatggcga aggcgcgccg ccggcgaaac gcccgcgcac cgatcagatg gaaattgata 900
gcggcaccgg caaacgcccg cataaaagcg gctttaccga taaagaacgc gaagatcatc 960
gccgccgcaa agcgctggaa aacaaaaaaa aacagctgag cagcggcggc aaaaacctga 1020
gccgcgaaga agaagaagaa ctgggccgcc tgaccgtgga agatgaagaa cgccgccgcc 1080
gcgtggcggg cccgcgcacc ggcgatgtga acctgagcgg cggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg cgcatggaag gcgtgccgga aagcccgttt acccgcaccg 1200
gcgaaggcct ggatattcgc ggcaaccagg gctttccgtg ggtgcgcccg agcccgccgc 1260
agcagcgcct gccgctgctg gaatgcaccc cgcagggcac caacctgagc accagcaacc 1320
cgctgggctt ttttccggat catcagctgg atccggcgtt tcgcgcgaac agcgcgaacc 1380
cggattggga ttttaacccg aacaaagata cctggccgga tgcgaacaaa gtgggcggcc 1440
agaacctgag caccagcaac ccgctgggct tttttccgga tcatcagctg gatccggcgt 1500
ttcgcgcgaa caccgcgaac ccggattggg attttaaccc gaacaaagat acctggccgg 1560
atgcgaacaa agtgggctga tgagaattcc gt                               1592

<210> 47
<211> 1563
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 8 optimized

<400> 47
gccagtcaga gcgagacccg cagaggacgg agaggaacac gagaagagac actggagaaa 60
tggattacag cacggaagaa ggcagaagag ctggagaagg acctgaggaa gacccgcaag 120
acaatcaaga agctggagga ggagaacccc tggctgggca atatcgtggg catcatcagg 180
aagggcaagg atggagaggg agcaccacct gccaagaggc ctcgcacaga ccagatggag 240
gtggatagcg gaccaggcaa gcggcctcac aagtccggct tcaccgacaa ggagagagag 300
gatcaccgga gaaggaaggc cctggagaac aagaagaagc agctgtccgc cggcggcaag 360
atcctgtcta aggaggagga ggaggagctg cgccggctga cagacgagga tgaggagagg 420
aagagaaggg tggcaggacc aagggtgggc gacgtgaatc cttctagggg aggaccaagg 480
ggagcaccag gaggaggctt cgtgcctcag atggccggcg tgccagagtc tccctttagc 540
cggacaggcg agggcctgga tatcagaggc acccagggct ttccttgggt gtctccaagc 600
ccaccacagc agcggctgcc actgctggag tgcacacccc agtcccagtc tgagagcaag 660
aagaacagga ggggaggaag agaggacatc ctggagaagt ggatcaccac aagaaggaag 720
gccgaggagc tggagaagga cctgcggaag gccagaaaga ccatcaagaa gctggaggat 780
gaaaatcctt ggctgggaaa tatcatcgga attattagaa aaggcaagga cggagaggga 840
gcacctccag caaagcggcc aagaacagac cagatggaga tcgattctgg aaccggcaag 900
aggccccaca agagtggctt caccgataag gagcgcgagg atcaccgccg gagaaaggcc 960
ctggaaaaca agaagaagca attaagctcc ggcggcaaga atctgagcag agaagaagag 1020
gaggagctgg gccgcctgac agtggaggac gaggagaggc gccggagagt ggcaggacct 1080
agaaccggcg atgtgaacct gtccggaggc ggcccaaggg gagcacctgg aggcggcttc 1140
gtgccacgca tggagggcgt gcctgagtct cccttcacca ggacaggaga gggcctggac 1200
atcagaggca atcagggatt cccatgggtg cggcccagcc cacctcagca gagactgcct 1260
ctgctggagt gtaccccaca gggcacaaac ctgtccacct ctaatcctct gggcttcttt 1320
ccagaccacc agctggatcc agccttcagg gccaactccg ccaaccctga ctgggacttc 1380
aaccctaata aggacacatg gccagatgcc aacaaggtcg gcggccagaa cctgagcacc 1440
tccaatcccc tgggcttctt tcctgaccac cagctggatc ccgcctttcg cgccaatacc 1500
gccaatcccg actgggactt caatccaaat aaggacacct ggcccgatgc taacaaagtg 1560
gga                                                               1563

<210> 48
<211> 1592
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 8 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 48
aagcttgcac catggccagt cagagcgaga cccgcagagg acggagagga acacgagaag 60
agacactgga gaaatggatt acagcacgga agaaggcaga agagctggag aaggacctga 120
ggaagacccg caagacaatc aagaagctgg aggaggagaa cccctggctg ggcaatatcg 180
tgggcatcat caggaagggc aaggatggag agggagcacc acctgccaag aggcctcgca 240
cagaccagat ggaggtggat agcggaccag gcaagcggcc tcacaagtcc ggcttcaccg 300
acaaggagag agaggatcac cggagaagga aggccctgga gaacaagaag aagcagctgt 360
ccgccggcgg caagatcctg tctaaggagg aggaggagga gctgcgccgg ctgacagacg 420
aggatgagga gaggaagaga agggtggcag gaccaagggt gggcgacgtg aatccttcta 480
ggggaggacc aaggggagca ccaggaggag gcttcgtgcc tcagatggcc ggcgtgccag 540
agtctccctt tagccggaca ggcgagggcc tggatatcag aggcacccag ggctttcctt 600
gggtgtctcc aagcccacca cagcagcggc tgccactgct ggagtgcaca ccccagtccc 660
agtctgagag caagaagaac aggaggggag gaagagagga catcctggag aagtggatca 720
ccacaagaag gaaggccgag gagctggaga aggacctgcg gaaggccaga aagaccatca 780
agaagctgga ggatgaaaat ccttggctgg gaaatatcat cggaattatt agaaaaggca 840
aggacggaga gggagcacct ccagcaaagc ggccaagaac agaccagatg gagatcgatt 900
ctggaaccgg caagaggccc cacaagagtg gcttcaccga taaggagcgc gaggatcacc 960
gccggagaaa ggccctggaa aacaagaaga agcaattaag ctccggcggc aagaatctga 1020
gcagagaaga agaggaggag ctgggccgcc tgacagtgga ggacgaggag aggcgccgga 1080
gagtggcagg acctagaacc ggcgatgtga acctgtccgg aggcggccca aggggagcac 1140
ctggaggcgg cttcgtgcca cgcatggagg gcgtgcctga gtctcccttc accaggacag 1200
gagagggcct ggacatcaga ggcaatcagg gattcccatg ggtgcggccc agcccacctc 1260
agcagagact gcctctgctg gagtgtaccc cacagggcac aaacctgtcc acctctaatc 1320
ctctgggctt ctttccagac caccagctgg atccagcctt cagggccaac tccgccaacc 1380
ctgactggga cttcaaccct aataaggaca catggccaga tgccaacaag gtcggcggcc 1440
agaacctgag cacctccaat cccctgggct tctttcctga ccaccagctg gatcccgcct 1500
ttcgcgccaa taccgccaat cccgactggg acttcaatcc aaataaggac acctggcccg 1560
atgctaacaa agtgggatga tgagaattcc gt                               1592

<210> 49
<211> 522
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 8 protein

<400> 49
Met Ala Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu
 1               5                  10                  15      
Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu
            20                  25                  30          
Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu
        35                  40                  45              
Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys
    50                  55                  60                  
Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr
            180                 185                 190         
Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro
        195                 200                 205             
Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg
225                 230                 235                 240 
Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile
                245                 250                 255     
Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile
            260                 265                 270         
Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His
    290                 295                 300                 
Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu
                325                 330                 335     
Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu
            340                 345                 350         
Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu
        355                 360                 365             
Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg
    370                 375                 380                 
Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro
                405                 410                 415     
Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu
            420                 425                 430         
Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro
        435                 440                 445             
Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn
    450                 455                 460                 
Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser
465                 470                 475                 480 
Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala
                485                 490                 495     
Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys
            500                 505                 510         
Asp Thr Trp Pro Asp Ala Asn Lys Val Gly
        515                 520         


<210> 50
<211> 1278
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 9 wt

<400> 50
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg 60
ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt 120
aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa 180
gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg 240
gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat 300
catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc 360
ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa 420
cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc 480
gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc 540
accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg 600
gcggatccgc cgtttagccc gcagagctgc cgcccgcaga gccgcagcga aagcaaaaaa 660
aaccgcggcg gccgcgaaga agtgctggaa cagtgggtga acggccgcaa aaaactggaa 720
gaactggaac gcgaactgcg ccgcgcgcgc aaaaaaatta aaaaactgga agatgataac 780
ccgtggctgg gcaacgtgaa aggcattctg ggcaaaaaag ataaagatgg cgaaggcgcg 840
ccgccggcga aacgcgcgcg caccgatcag atggaaattg atagcggccc gcgcaaacgc 900
ccgctgcgcg gcggctttac cgatcgcgaa cgccaggatc atcgccgccg caaagcgctg 960
aaaaacaaaa aaaaacagct gagcgcgggc ggcaaaagcc tgagcaaaga agaagaagaa 1020
gaactgaaac gcctgacccg cgaagatgaa gaacgcaaaa aagaagaaca tggcccgagc 1080
cgcctgggcg tgaacccgag cgaaggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgagcatgc agggcattcc ggaaagccgc tttacccgca ccggcgaagg cctggatgtg 1200
cgcggcagcc gcggctttcc gcaggatatt ctgtttccga gcgatccgcc gtttagcccg 1260
cagagctgcc gcccgcag                                               1278

<210> 51
<211> 1310
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 9 wt with restriction sites (HindIII /EcoRI)

<400> 51
aagcttgcac catggccagc cgcagcgaaa gcaaaaaaaa ccgcggcggc cgcgaagaaa 60
ttctggaaca gtgggtgggc gcgcgcaaaa aactggaaga actggaacgc gatctgcgca 120
aaattaaaaa aaaaattaaa aaactggaag aagaaaaccc gtggctgggc aacattaaag 180
gcattctggg caaaaaagat cgcgaaggcg aaggcgcgcc gccggcgaaa cgcgcgcgcg 240
cggatcagat ggaagtggat agcggcccgc gcaaacgccc gtttcgcggc gaatttaccg 300
ataaagaacg ccgcgatcat cgccgccgca aagcgctgga aaacaaacgc aaacagctga 360
gcagcggcgg caaaagcctg agcaaagaag aagaagaaga actgcgcaaa ctgaccgaag 420
aagatgaacg ccgcgaacgc cgcgtggcgg gcccgcgcgt gggcggcgtg aacccgctgg 480
aaggcggcac ccgcggcgcg ccgggcggcg gctttgtgcc gagcatgcag ggcgtgccgg 540
aaagcccgtt tgcgcgcacc ggcgaaggcc tggatgtgcg cggcaaccag ggctttccgt 600
gggatattct gtttccggcg gatccgccgt ttagcccgca gagctgccgc ccgcagagcc 660
gcagcgaaag caaaaaaaac cgcggcggcc gcgaagaagt gctggaacag tgggtgaacg 720
gccgcaaaaa actggaagaa ctggaacgcg aactgcgccg cgcgcgcaaa aaaattaaaa 780
aactggaaga tgataacccg tggctgggca acgtgaaagg cattctgggc aaaaaagata 840
aagatggcga aggcgcgccg ccggcgaaac gcgcgcgcac cgatcagatg gaaattgata 900
gcggcccgcg caaacgcccg ctgcgcggcg gctttaccga tcgcgaacgc caggatcatc 960
gccgccgcaa agcgctgaaa aacaaaaaaa aacagctgag cgcgggcggc aaaagcctga 1020
gcaaagaaga agaagaagaa ctgaaacgcc tgacccgcga agatgaagaa cgcaaaaaag 1080
aagaacatgg cccgagccgc ctgggcgtga acccgagcga aggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg agcatgcagg gcattccgga aagccgcttt acccgcaccg 1200
gcgaaggcct ggatgtgcgc ggcagccgcg gctttccgca ggatattctg tttccgagcg 1260
atccgccgtt tagcccgcag agctgccgcc cgcagtgatg agaattccgt            1310

<210> 52
<211> 1281
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 9 codon optimized

<400> 52
gccagtcgga gcgaatcaaa gaaaaataga gggggaagag aagaaatcct ggagcagtgg 60
gtcggggcac ggaaaaaact ggaagaactg gagcgggacc tgagaaagat caagaagaag 120
atcaagaagc tggaggaaga gaacccctgg ctgggcaata tcaagggcat cctgggcaag 180
aaggataggg agggcgaggg agcaccacct gcaaagaggg caagggcaga ccagatggag 240
gtggattccg gaccaaggaa gcggcccttc cggggagagt ttaccgacaa ggagcggaga 300
gatcacaggc gccggaaggc cctggagaac aagcggaagc agctgagctc cggcggcaag 360
tctctgagca aggaggagga ggaggagctg agaaagctga cagaggagga cgagagaagg 420
gagaggaggg tggcaggacc tagggtggga ggcgtgaacc cactggaggg aggaaccagg 480
ggagcacctg gaggaggctt tgtgccatct atgcagggag tgccagagag ccctttcgcc 540
aggacaggag agggcctgga tgtgcgcggc aatcagggct tcccctggga catcctgttt 600
cctgccgatc cacccttcag cccacagtcc tgcaggccac agtcccgctc tgagagcaag 660
aagaacaggg gaggaaggga ggaggtgctg gagcagtggg tgaatggccg gaagaagctg 720
gaggagctgg agcgggagct gagaagggcc agaaagaaga tcaagaagct ggaagacgat 780
aatccttggc tgggcaatgt gaaaggcatc ctgggcaaga aggacaagga tggagaggga 840
gcacctccag caaagagggc acgcaccgac cagatggaga tcgattctgg acctaggaag 900
cggcccctga gaggaggctt tacagacagg gagcgccagg atcaccgccg gagaaaggcc 960
ctgaagaaca agaagaagca gctgagcgcc ggcggcaagt ccctgtctaa agaagaggag 1020
gaggagctga agcggctgac cagagaggac gaggagcgga agaaggagga gcacggacca 1080
tccagactgg gagtgaatcc ttctgaggga ggaccaagag gcgccccagg cggcggcttt 1140
gtgccaagca tgcagggcat ccccgagtcc aggttcacca gaaccggcga aggcctggat 1200
gtgcggggca gcagaggctt cccccaggat attctgtttc cctccgaccc ccccttcagt 1260
ccccagtctt gccgacctca g                                           1281

<210> 53
<211> 1310
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 9 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 53
aagcttgcac catggccagt cggagcgaat caaagaaaaa tagaggggga agagaagaaa 60
tcctggagca gtgggtcggg gcacggaaaa aactggaaga actggagcgg gacctgagaa 120
agatcaagaa gaagatcaag aagctggagg aagagaaccc ctggctgggc aatatcaagg 180
gcatcctggg caagaaggat agggagggcg agggagcacc acctgcaaag agggcaaggg 240
cagaccagat ggaggtggat tccggaccaa ggaagcggcc cttccgggga gagtttaccg 300
acaaggagcg gagagatcac aggcgccgga aggccctgga gaacaagcgg aagcagctga 360
gctccggcgg caagtctctg agcaaggagg aggaggagga gctgagaaag ctgacagagg 420
aggacgagag aagggagagg agggtggcag gacctagggt gggaggcgtg aacccactgg 480
agggaggaac caggggagca cctggaggag gctttgtgcc atctatgcag ggagtgccag 540
agagcccttt cgccaggaca ggagagggcc tggatgtgcg cggcaatcag ggcttcccct 600
gggacatcct gtttcctgcc gatccaccct tcagcccaca gtcctgcagg ccacagtccc 660
gctctgagag caagaagaac aggggaggaa gggaggaggt gctggagcag tgggtgaatg 720
gccggaagaa gctggaggag ctggagcggg agctgagaag ggccagaaag aagatcaaga 780
agctggaaga cgataatcct tggctgggca atgtgaaagg catcctgggc aagaaggaca 840
aggatggaga gggagcacct ccagcaaaga gggcacgcac cgaccagatg gagatcgatt 900
ctggacctag gaagcggccc ctgagaggag gctttacaga cagggagcgc caggatcacc 960
gccggagaaa ggccctgaag aacaagaaga agcagctgag cgccggcggc aagtccctgt 1020
ctaaagaaga ggaggaggag ctgaagcggc tgaccagaga ggacgaggag cggaagaagg 1080
aggagcacgg accatccaga ctgggagtga atccttctga gggaggacca agaggcgccc 1140
caggcggcgg ctttgtgcca agcatgcagg gcatccccga gtccaggttc accagaaccg 1200
gcgaaggcct ggatgtgcgg ggcagcagag gcttccccca ggatattctg tttccctccg 1260
accccccctt cagtccccag tcttgccgac ctcagtgatg agaattccgt            1310

<210> 54
<211> 428
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 9 protein

<400> 54
Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu
 1               5                  10                  15      
Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu
            20                  25                  30          
Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu
        35                  40                  45              
Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg
    50                  55                  60                  
Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn
            180                 185                 190         
Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser
        195                 200                 205             
Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys
225                 230                 235                 240 
Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys
                245                 250                 255     
Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu
            260                 265                 270         
Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu
    290                 295                 300                 
Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu
                325                 330                 335     
Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu
            340                 345                 350         
Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro
        355                 360                 365             
Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser
    370                 375                 380                 
Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser
                405                 410                 415     
Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln
            420                 425             


<210> 55
<211> 1278
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 10 wt

<400> 55
agccagagcg aaacccgccg cggccgccgc ggcacccgcg aagaaaccct ggaaaaatgg 60
attaccgcgc gcaaaaaagc ggaagaactg gaaaaagatc tgcgcaaaac ccgcaaaacc 120
attaaaaaac tggaagaaga aaacccgtgg ctgggcaaca ttgtgggcat tattcgcaaa 180
ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaagtg 240
gatagcggcc cgggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat 300
catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcgcggg cggcaaaatt 360
ctgagcaaag aagaagaaga agaactgcgc cgcctgaccg atgaagatga agaacgcaaa 420
cgccgcgtgg cgggcccgcg cgtgggcgat gtgaacccga gccgcggcgg cccgcgcggc 480
gcgccgggcg gcggctttgt gccgcagatg gcgggcgtgc cggaaagccc gtttagccgc 540
accggcgaag gcctggatat tcgcggcacc cagggctttc cgtgggtgag cccgagcccg 600
ccgcagcagc gcctgccgct gctggaatgc accccgcaga gccagagcga aagcaaaaaa 660
aaccgccgcg gcggccgcga agatattctg gaaaaatgga ttaccacccg ccgcaaagcg 720
gaagaactgg aaaaagatct gcgcaaagcg cgcaaaacca ttaaaaaact ggaagatgaa 780
aacccgtggc tgggcaacat tattggcatt attcgcaaag gcaaagatgg cgaaggcgcg 840
ccgccggcga aacgcccgcg caccgatcag atggaaattg atagcggcac cggcaaacgc 900
ccgcataaaa gcggctttac cgataaagaa cgcgaagatc atcgccgccg caaagcgctg 960
gaaaacaaaa aaaaacagct gagcagcggc ggcaaaaacc tgagccgcga agaagaagaa 1020
gaactgggcc gcctgaccgt ggaagatgaa gaacgccgcc gccgcgtggc gggcccgcgc 1080
accggcgatg tgaacctgag cggcggcggc ccgcgcggcg cgccgggcgg cggctttgtg 1140
ccgcgcatgg aaggcgtgcc ggaaagcccg tttacccgca ccggcgaagg cctggatatt 1200
cgcggcaacc agggctttcc gtgggtgcgc ccgagcccgc cgcagcagcg cctgccgctg 1260
ctggaatgca ccccgcag                                               1278

<210> 56
<211> 1310
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 10 wt with restriction sites (HindIII
      /EcoRI)

<400> 56
aagcttgcac catggccagc cagagcgaaa cccgccgcgg ccgccgcggc acccgcgaag 60
aaaccctgga aaaatggatt accgcgcgca aaaaagcgga agaactggaa aaagatctgc 120
gcaaaacccg caaaaccatt aaaaaactgg aagaagaaaa cccgtggctg ggcaacattg 180
tgggcattat tcgcaaaggc aaagatggcg aaggcgcgcc gccggcgaaa cgcccgcgca 240
ccgatcagat ggaagtggat agcggcccgg gcaaacgccc gcataaaagc ggctttaccg 300
ataaagaacg cgaagatcat cgccgccgca aagcgctgga aaacaaaaaa aaacagctga 360
gcgcgggcgg caaaattctg agcaaagaag aagaagaaga actgcgccgc ctgaccgatg 420
aagatgaaga acgcaaacgc cgcgtggcgg gcccgcgcgt gggcgatgtg aacccgagcc 480
gcggcggccc gcgcggcgcg ccgggcggcg gctttgtgcc gcagatggcg ggcgtgccgg 540
aaagcccgtt tagccgcacc ggcgaaggcc tggatattcg cggcacccag ggctttccgt 600
gggtgagccc gagcccgccg cagcagcgcc tgccgctgct ggaatgcacc ccgcagagcc 660
agagcgaaag caaaaaaaac cgccgcggcg gccgcgaaga tattctggaa aaatggatta 720
ccacccgccg caaagcggaa gaactggaaa aagatctgcg caaagcgcgc aaaaccatta 780
aaaaactgga agatgaaaac ccgtggctgg gcaacattat tggcattatt cgcaaaggca 840
aagatggcga aggcgcgccg ccggcgaaac gcccgcgcac cgatcagatg gaaattgata 900
gcggcaccgg caaacgcccg cataaaagcg gctttaccga taaagaacgc gaagatcatc 960
gccgccgcaa agcgctggaa aacaaaaaaa aacagctgag cagcggcggc aaaaacctga 1020
gccgcgaaga agaagaagaa ctgggccgcc tgaccgtgga agatgaagaa cgccgccgcc 1080
gcgtggcggg cccgcgcacc ggcgatgtga acctgagcgg cggcggcccg cgcggcgcgc 1140
cgggcggcgg ctttgtgccg cgcatggaag gcgtgccgga aagcccgttt acccgcaccg 1200
gcgaaggcct ggatattcgc ggcaaccagg gctttccgtg ggtgcgcccg agcccgccgc 1260
agcagcgcct gccgctgctg gaatgcaccc cgcagtgatg agaattccgt            1310

<210> 57
<211> 1281
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 10 codon optimized

<400> 57
gcctcacaga gcgaaacacg gcgggggcgg aggggaacta gagaggaaac actggaaaaa 60
tggattacag cacggaaaaa ggcagaggaa ctggagaagg acctgaggaa gacccgcaag 120
acaatcaaga agctggagga ggagaaccca tggctgggca atatcgtggg catcatccgg 180
aagggcaagg atggagaggg agcaccacct gcaaagaggc cccgcaccga ccagatggag 240
gtggattctg gccctggcaa gaggccacac aagagcggct tcacagacaa ggagcgcgag 300
gatcaccgga gaaggaaggc cctggagaac aagaagaagc agctgagcgc cggcggcaag 360
atcctgtcca aggaggagga ggaggagctg cgccggctga ccgacgagga tgaggagcgg 420
aagagaaggg tggcaggacc aagagtgggc gacgtgaatc cctctagggg aggaccaagg 480
ggagcacctg gaggaggctt cgtgcctcag atggcaggag tgccagagtc ccctttttct 540
aggaccggag agggcctgga tatcagggga acacagggct ttccatgggt gtctccaagc 600
ccaccacagc agaggctgcc actgctggag tgcacccctc agtcccagtc tgagagcaag 660
aagaacagga ggggaggaag ggaggacatc ctggagaagt ggatcaccac aagaaggaag 720
gccgaggagc tggagaagga cctgcggaag gccagaaaaa caatcaagaa gctggaagat 780
gagaacccct ggctgggcaa tatcatcggc atcatcagaa aaggcaagga cggcgaggga 840
gcacctccag caaagcggcc tagaaccgac cagatggaga tcgattccgg cacaggcaag 900
cggccacaca agtctggctt caccgacaag gagagagagg atcaccgccg gagaaaggcc 960
ctggaaaaca agaagaagca attaagctcc ggcggcaaga atctgagcag agaagaagag 1020
gaggagctgg gcagactgac cgtggaggac gaggagaggc gccggagagt ggcaggaccc 1080
agaacaggcg atgtgaacct gagcggagga ggacctaggg gagcaccagg aggcggcttc 1140
gtgcctagaa tggagggcgt gccagagtcc ccctttacca ggacaggaga gggcctggac 1200
atcaggggca atcagggctt tccctgggtc cgcccttcac caccacagca gagactgccc 1260
ctgctggaat gcacaccaca g                                           1281

<210> 58
<211> 1310
<212> DNA
<213> Artificial Sequence

<220> 
<223> Delta 10 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 58
aagcttgcac catggcctca cagagcgaaa cacggcgggg gcggagggga actagagagg 60
aaacactgga aaaatggatt acagcacgga aaaaggcaga ggaactggag aaggacctga 120
ggaagacccg caagacaatc aagaagctgg aggaggagaa cccatggctg ggcaatatcg 180
tgggcatcat ccggaagggc aaggatggag agggagcacc acctgcaaag aggccccgca 240
ccgaccagat ggaggtggat tctggccctg gcaagaggcc acacaagagc ggcttcacag 300
acaaggagcg cgaggatcac cggagaagga aggccctgga gaacaagaag aagcagctga 360
gcgccggcgg caagatcctg tccaaggagg aggaggagga gctgcgccgg ctgaccgacg 420
aggatgagga gcggaagaga agggtggcag gaccaagagt gggcgacgtg aatccctcta 480
ggggaggacc aaggggagca cctggaggag gcttcgtgcc tcagatggca ggagtgccag 540
agtccccttt ttctaggacc ggagagggcc tggatatcag gggaacacag ggctttccat 600
gggtgtctcc aagcccacca cagcagaggc tgccactgct ggagtgcacc cctcagtccc 660
agtctgagag caagaagaac aggaggggag gaagggagga catcctggag aagtggatca 720
ccacaagaag gaaggccgag gagctggaga aggacctgcg gaaggccaga aaaacaatca 780
agaagctgga agatgagaac ccctggctgg gcaatatcat cggcatcatc agaaaaggca 840
aggacggcga gggagcacct ccagcaaagc ggcctagaac cgaccagatg gagatcgatt 900
ccggcacagg caagcggcca cacaagtctg gcttcaccga caaggagaga gaggatcacc 960
gccggagaaa ggccctggaa aacaagaaga agcaattaag ctccggcggc aagaatctga 1020
gcagagaaga agaggaggag ctgggcagac tgaccgtgga ggacgaggag aggcgccgga 1080
gagtggcagg acccagaaca ggcgatgtga acctgagcgg aggaggacct aggggagcac 1140
caggaggcgg cttcgtgcct agaatggagg gcgtgccaga gtcccccttt accaggacag 1200
gagagggcct ggacatcagg ggcaatcagg gctttccctg ggtccgccct tcaccaccac 1260
agcagagact gcccctgctg gaatgcacac cacagtgatg agaattccgt            1310

<210> 59
<211> 428
<212> PRT
<213> Artificial Sequence

<220> 
<223> Delta 10 protein

<400> 59
Met Ala Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu
 1               5                  10                  15      
Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu
            20                  25                  30          
Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu
        35                  40                  45              
Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys
    50                  55                  60                  
Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met
65                  70                  75                  80  
Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr
                85                  90                  95      
Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys
            100                 105                 110         
Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu
        115                 120                 125             
Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg
    130                 135                 140                 
Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro
145                 150                 155                 160 
Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro
                165                 170                 175     
Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr
            180                 185                 190         
Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro
        195                 200                 205             
Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg
    210                 215                 220                 
Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg
225                 230                 235                 240 
Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile
                245                 250                 255     
Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile
            260                 265                 270         
Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro
        275                 280                 285             
Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His
    290                 295                 300                 
Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys
305                 310                 315                 320 
Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu
                325                 330                 335     
Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu
            340                 345                 350         
Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu
        355                 360                 365             
Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg
    370                 375                 380                 
Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu
385                 390                 395                 400 
Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro
                405                 410                 415     
Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln
            420                 425             


<210> 60
<211> 546
<212> DNA
<213> Artificial Sequence

<220> 
<223> Core 1 wt (C-gt-H)

<400> 60
gatattgatc cgtataaaga atttggcgcg agcgtggaac tgctgagctt tctgccgagc 60
gatttttttc cgagcgtgcg cgatctgctg gataccgcga gcgcgctgta tcgcgatgcg 120
ctggaaagcc cggaacattg caccccgaac cataccgcgc tgcgccaggc gattctgtgc 180
tggggcgaac tgatgaccct ggcgagctgg gtgggcaaca acctggaaga tccggcggcg 240
cgcgatctgg tggtgaacta tgtgaacacc aacatgggcc tgaaaattcg ccagctgctg 300
tggtttcata ttagctgcct gacctttggc cgcgaaaccg tgctggaata tctggtgagc 360
tttggcgtgt ggattcgcac cccgccggcg tatcgcccgc cgaacgcgcc gattctgagc 420
accctgccgg aaaccaccgt ggtgcgccag cgcggccgcg cgccgcgccg ccgcaccccg 480
agcccgcgcc gccgccgcag ccagagcccg cgccgccgcc gcagccagag cccggcgagc 540
cagtgc                                                            546

<210> 61
<211> 575
<212> DNA
<213> Artificial Sequence

<220> 
<223> Core 1 wt with restriction sites (HindIII /EcoRI)

<400> 61
aagcttgcac catggatatt gatccgtata aagaatttgg cgcgagcgtg gaactgctga 60
gctttctgcc gagcgatttt tttccgagcg tgcgcgatct gctggatacc gcgagcgcgc 120
tgtatcgcga tgcgctggaa agcccggaac attgcacccc gaaccatacc gcgctgcgcc 180
aggcgattct gtgctggggc gaactgatga ccctggcgag ctgggtgggc aacaacctgg 240
aagatccggc ggcgcgcgat ctggtggtga actatgtgaa caccaacatg ggcctgaaaa 300
ttcgccagct gctgtggttt catattagct gcctgacctt tggccgcgaa accgtgctgg 360
aatatctggt gagctttggc gtgtggattc gcaccccgcc ggcgtatcgc ccgccgaacg 420
cgccgattct gagcaccctg ccggaaacca ccgtggtgcg ccagcgcggc cgcgcgccgc 480
gccgccgcac cccgagcccg cgccgccgcc gcagccagag cccgcgccgc cgccgcagcc 540
agagcccggc gagccagtgc tgatgagaat tccgt                            575

<210> 62
<211> 546
<212> DNA
<213> Artificial Sequence

<220> 
<223> Core 1 codon optimized

<400> 62
gatattgatc cctataagga gtttggagcc tctgtggagc tgctgagttt tctgccatcc 60
gatttctttc ccagtgtccg agacctgctg gacaccgcaa gcgccctgta cagggatgca 120
ctggagtccc cagagcactg cacccctaac cacacagccc tgaggcaggc aatcctgtgc 180
tggggagagc tgatgaccct ggcaagctgg gtgggcaaca atctggagga ccctgcagca 240
cgggatctgg tggtgaatta tgtgaacaca aatatgggcc tgaagatccg gcagctgctg 300
tggttccaca tctcttgcct gacctttggc agagagacag tgctggagta cctggtgagc 360
ttcggcgtgt ggatcaggac cccacctgca tataggccac caaacgcacc aatcctgtcc 420
acactgccag agacaacagt ggtgcgccag aggggaagag caccacggag aaggacacct 480
tctccaagac gaaggcgaag ccagagcccc aggcgaagac gaagccagtc cccagcaagc 540
cagtgc                                                            546

<210> 63
<211> 575
<212> DNA
<213> Artificial Sequence

<220> 
<223> Core 1 codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 63
aagcttgcac catggatatt gatccctata aggagtttgg agcctctgtg gagctgctga 60
gttttctgcc atccgatttc tttcccagtg tccgagacct gctggacacc gcaagcgccc 120
tgtacaggga tgcactggag tccccagagc actgcacccc taaccacaca gccctgaggc 180
aggcaatcct gtgctgggga gagctgatga ccctggcaag ctgggtgggc aacaatctgg 240
aggaccctgc agcacgggat ctggtggtga attatgtgaa cacaaatatg ggcctgaaga 300
tccggcagct gctgtggttc cacatctctt gcctgacctt tggcagagag acagtgctgg 360
agtacctggt gagcttcggc gtgtggatca ggaccccacc tgcatatagg ccaccaaacg 420
caccaatcct gtccacactg ccagagacaa cagtggtgcg ccagagggga agagcaccac 480
ggagaaggac accttctcca agacgaaggc gaagccagag ccccaggcga agacgaagcc 540
agtccccagc aagccagtgc tgatgagaat tccgt                            575

<210> 64
<211> 183
<212> PRT
<213> Artificial Sequence

<220> 
<223> Core 1 protein

<400> 64
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu
 1               5                  10                  15      
Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp
            20                  25                  30          
Thr Ala Ser Ala Leu Tyr Arg Asp Ala Leu Glu Ser Pro Glu His Cys
        35                  40                  45              
Thr Pro Asn His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu
    50                  55                  60                  
Leu Met Thr Leu Ala Ser Trp Val Gly Asn Asn Leu Glu Asp Pro Ala
65                  70                  75                  80  
Ala Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu Lys
                85                  90                  95      
Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg
            100                 105                 110         
Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu Thr Thr Val Val Arg Gln Arg Gly Arg Ala Pro Arg Arg Arg Thr
145                 150                 155                 160 
Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser
                165                 170                 175     
Gln Ser Pro Ala Ser Gln Cys
            180             


<210> 65
<211> 633
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pre-C-gt-H wt

<400> 65
cagctgtttc atctgtgcct gattattttt tgcagctgcc cgaccgtgca ggcgagcaaa 60
ctgtgcctgg gctggctgtg gggcatggat attgatccgt ataaagaatt tggcgcgagc 120
gtggaactgc tgagctttct gccgagcgat ttttttccga gcgtgcgcga tctgctggat 180
accgcgagcg cgctgtatcg cgatgcgctg gaaagcccgg aacattgcac cccgaaccat 240
accgcgctgc gccaggcgat tctgtgctgg ggcgaactga tgaccctggc gagctgggtg 300
ggcaacaacc tggaagatcc ggcggcgcgc gatctggtgg tgaactatgt gaacaccaac 360
atgggcctga aaattcgcca gctgctgtgg tttcatatta gctgcctgac ctttggccgc 420
gaaaccgtgc tggaatatct ggtgagcttt ggcgtgtgga ttcgcacccc gccggcgtat 480
cgcccgccga acgcgccgat tctgagcacc ctgccggaaa ccaccgtggt gcgccagcgc 540
ggccgcgcgc cgcgccgccg caccccgagc ccgcgccgcc gccgcagcca gagcccgcgc 600
cgccgccgca gccagagccc ggcgagccag tgc                              633

<210> 66
<211> 665
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pre-C-gt-H wt with restriction sites (HindIII
      /EcoRI)

<400> 66
aagcttgcac catggcccag ctgtttcatc tgtgcctgat tattttttgc agctgcccga 60
ccgtgcaggc gagcaaactg tgcctgggct ggctgtgggg catggatatt gatccgtata 120
aagaatttgg cgcgagcgtg gaactgctga gctttctgcc gagcgatttt tttccgagcg 180
tgcgcgatct gctggatacc gcgagcgcgc tgtatcgcga tgcgctggaa agcccggaac 240
attgcacccc gaaccatacc gcgctgcgcc aggcgattct gtgctggggc gaactgatga 300
ccctggcgag ctgggtgggc aacaacctgg aagatccggc ggcgcgcgat ctggtggtga 360
actatgtgaa caccaacatg ggcctgaaaa ttcgccagct gctgtggttt catattagct 420
gcctgacctt tggccgcgaa accgtgctgg aatatctggt gagctttggc gtgtggattc 480
gcaccccgcc ggcgtatcgc ccgccgaacg cgccgattct gagcaccctg ccggaaacca 540
ccgtggtgcg ccagcgcggc cgcgcgccgc gccgccgcac cccgagcccg cgccgccgcc 600
gcagccagag cccgcgccgc cgccgcagcc agagcccggc gagccagtgc tgatgagaat 660
tccgt                                                             665

<210> 67
<211> 636
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pre-C-gt-H codon optimized

<400> 67
gcccagctgt ttcatctgtg cctgattatt ttctgttcat gccctaccgt ccaggcttct 60
aaactgtgcc tggggtggct gtggggaatg gacatcgatc cctacaagga gttcggcgcc 120
agcgtggagc tgctgagctt tctgccctcc gacttctttc cttctgtgcg ggacctgctg 180
gataccgcaa gcgccctgta tagagatgca ctggagtccc cagagcactg caccccaaac 240
cacacagccc tgaggcaggc aatcctgtgc tggggagagc tgatgaccct ggcatcctgg 300
gtgggcaaca atctggagga ccctgccgcc agagatctgg tggtgaatta cgtgaacaca 360
aatatgggcc tgaagatcag gcagctgctg tggttccaca tctcttgcct gacctttggc 420
cgcgagacag tgctggagta cctggtgagc ttcggcgtgt ggatcaggac cccacctgca 480
tataggccac caaacgcacc tatcctgtcc acactgccag agacaacagt ggtgcgccag 540
aggggaagag caccacggag aaggacacct tctccaagga ggagaagaag ccagtcccca 600
cgaagaagac gaagccagag cccagccagc cagtgt                           636

<210> 68
<211> 665
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pre-C-gt-H codon optimized with restriction sites
      (HindIII /EcoRI)

<400> 68
aagcttgcac catggcccag ctgtttcatc tgtgcctgat tattttctgt tcatgcccta 60
ccgtccaggc ttctaaactg tgcctggggt ggctgtgggg aatggacatc gatccctaca 120
aggagttcgg cgccagcgtg gagctgctga gctttctgcc ctccgacttc tttccttctg 180
tgcgggacct gctggatacc gcaagcgccc tgtatagaga tgcactggag tccccagagc 240
actgcacccc aaaccacaca gccctgaggc aggcaatcct gtgctgggga gagctgatga 300
ccctggcatc ctgggtgggc aacaatctgg aggaccctgc cgccagagat ctggtggtga 360
attacgtgaa cacaaatatg ggcctgaaga tcaggcagct gctgtggttc cacatctctt 420
gcctgacctt tggccgcgag acagtgctgg agtacctggt gagcttcggc gtgtggatca 480
ggaccccacc tgcatatagg ccaccaaacg cacctatcct gtccacactg ccagagacaa 540
cagtggtgcg ccagagggga agagcaccac ggagaaggac accttctcca aggaggagaa 600
gaagccagtc cccacgaaga agacgaagcc agagcccagc cagccagtgt tgatgagaat 660
tccgt                                                             665

<210> 69
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pre-C-gt-H protein

<400> 69
Met Ala Gln Leu Phe His Leu Cys Leu Ile Ile Phe Cys Ser Cys Pro
 1               5                  10                  15      
Thr Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp
            20                  25                  30          
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser Phe
        35                  40                  45              
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
    50                  55                  60                  
Ser Ala Leu Tyr Arg Asp Ala Leu Glu Ser Pro Glu His Cys Thr Pro
65                  70                  75                  80  
Asn His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
                85                  90                  95      
Thr Leu Ala Ser Trp Val Gly Asn Asn Leu Glu Asp Pro Ala Ala Arg
            100                 105                 110         
Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu Lys Ile Arg
        115                 120                 125             
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
    130                 135                 140                 
Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
145                 150                 155                 160 
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
                165                 170                 175     
Thr Val Val Arg Gln Arg Gly Arg Ala Pro Arg Arg Arg Thr Pro Ser
            180                 185                 190         
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
        195                 200                 205             
Pro Ala Ser Gln Cys
    210             


<210> 70
<211> 633
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreC-C-Mut-gt-H wt

<400> 70
cagctgtttc atctgtgcct gattattttt tgcagctgcc cgacctttca gtttccgaaa 60
ctgtgcctgg gctggctgtg gggcatggat attgatccgt ataaagaatt tggcgcgagc 120
gtggaactgc tgagctttct gccgagcgat ttttttccga gcgtgcgcga tctgctggat 180
accgcgagcg cgctgtatcg cgatgcgctg gaaagcccgg aacattgcac cccgaaccat 240
accgcgctgc gccaggcgat tctgtgctgg ggcgaactga tgaccctggc gagctgggtg 300
ggcaacaacc tggaagatcc ggcggcgcgc gatctggtgg tgaactatgt gaacaccaac 360
atgggcctga aaattcgcca gctgctgtgg tttcatatta gctgcctgac ctttggccgc 420
gaaaccgtgc tggaatatct ggtgagcttt ggcgtgtgga ttcgcacccc gccggcgtat 480
cgcccgccga acgcgccgat tctgagcacc ctgccggaaa ccaccgtggt gcgccagcgc 540
ggccgcgcgc cgcgccgccg caccccgagc ccgcgccgcc gccgcagcca gagcccgcgc 600
cgccgccgca gccagagccc ggcgagccag tgc                              633

<210> 71
<211> 665
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreC-C-Mut-gt-H wt with restriction sites (HindIII
      /EcoRI)

<400> 71
aagcttgcac catggcccag ctgtttcatc tgtgcctgat tattttttgc agctgcccga 60
cctttcagtt tccgaaactg tgcctgggct ggctgtgggg catggatatt gatccgtata 120
aagaatttgg cgcgagcgtg gaactgctga gctttctgcc gagcgatttt tttccgagcg 180
tgcgcgatct gctggatacc gcgagcgcgc tgtatcgcga tgcgctggaa agcccggaac 240
attgcacccc gaaccatacc gcgctgcgcc aggcgattct gtgctggggc gaactgatga 300
ccctggcgag ctgggtgggc aacaacctgg aagatccggc ggcgcgcgat ctggtggtga 360
actatgtgaa caccaacatg ggcctgaaaa ttcgccagct gctgtggttt catattagct 420
gcctgacctt tggccgcgaa accgtgctgg aatatctggt gagctttggc gtgtggattc 480
gcaccccgcc ggcgtatcgc ccgccgaacg cgccgattct gagcaccctg ccggaaacca 540
ccgtggtgcg ccagcgcggc cgcgcgccgc gccgccgcac cccgagcccg cgccgccgcc 600
gcagccagag cccgcgccgc cgccgcagcc agagcccggc gagccagtgc tgatgagaat 660
tccgt                                                             665

<210> 72
<211> 636
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreC-C-Mut-gt-H codon optimized

<400> 72
gcccagctgt ttcatctgtg cctgattatt ttctgttcat gccctacctt ccagttcccc 60
aaactgtgcc tggggtggct gtggggaatg gacatcgatc cctacaagga gttcggcgcc 120
agcgtggagc tgctgagctt tctgccctcc gacttctttc cttctgtgcg ggacctgctg 180
gataccgcaa gcgccctgta tagagatgca ctggagtccc cagagcactg caccccaaac 240
cacacagccc tgaggcaggc aatcctgtgc tggggagagc tgatgaccct ggcatcctgg 300
gtgggcaaca atctggagga ccctgccgcc agagatctgg tggtgaatta cgtgaacaca 360
aatatgggcc tgaagatcag gcagctgctg tggttccaca tctcttgcct gacctttggc 420
cgcgagacag tgctggagta cctggtgagc ttcggcgtgt ggatcaggac cccacctgca 480
tataggccac caaacgcacc tatcctgtcc acactgccag agacaacagt ggtgcgccag 540
aggggaagag caccacggag aaggacacct tctccaagga ggagaagaag ccagtcccca 600
cgaagaagac gaagccagag cccagccagc cagtgt                           636

<210> 73
<211> 665
<212> DNA
<213> Artificial Sequence

<220> 
<223> PreC-C-Mut-gt-H codon optimized with restriction
      sites (HindIII /EcoRI)

<400> 73
aagcttgcac catggcccag ctgtttcatc tgtgcctgat tattttctgt tcatgcccta 60
ccttccagtt ccccaaactg tgcctggggt ggctgtgggg aatggacatc gatccctaca 120
aggagttcgg cgccagcgtg gagctgctga gctttctgcc ctccgacttc tttccttctg 180
tgcgggacct gctggatacc gcaagcgccc tgtatagaga tgcactggag tccccagagc 240
actgcacccc aaaccacaca gccctgaggc aggcaatcct gtgctgggga gagctgatga 300
ccctggcatc ctgggtgggc aacaatctgg aggaccctgc cgccagagat ctggtggtga 360
attacgtgaa cacaaatatg ggcctgaaga tcaggcagct gctgtggttc cacatctctt 420
gcctgacctt tggccgcgag acagtgctgg agtacctggt gagcttcggc gtgtggatca 480
ggaccccacc tgcatatagg ccaccaaacg cacctatcct gtccacactg ccagagacaa 540
cagtggtgcg ccagagggga agagcaccac ggagaaggac accttctcca aggaggagaa 600
gaagccagtc cccacgaaga agacgaagcc agagcccagc cagccagtgt tgatgagaat 660
tccgt                                                             665

<210> 74
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> PreC-C-Mut-gt-H protein

<400> 74
Met Ala Gln Leu Phe His Leu Cys Leu Ile Ile Phe Cys Ser Cys Pro
 1               5                  10                  15      
Thr Phe Gln Phe Pro Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp
            20                  25                  30          
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser Phe
        35                  40                  45              
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
    50                  55                  60                  
Ser Ala Leu Tyr Arg Asp Ala Leu Glu Ser Pro Glu His Cys Thr Pro
65                  70                  75                  80  
Asn His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
                85                  90                  95      
Thr Leu Ala Ser Trp Val Gly Asn Asn Leu Glu Asp Pro Ala Ala Arg
            100                 105                 110         
Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu Lys Ile Arg
        115                 120                 125             
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
    130                 135                 140                 
Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
145                 150                 155                 160 
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
                165                 170                 175     
Thr Val Val Arg Gln Arg Gly Arg Ala Pro Arg Arg Arg Thr Pro Ser
            180                 185                 190         
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
        195                 200                 205             
Pro Ala Ser Gln Cys
    210             


<210> 75
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#1

<400> 75
Met Gly Arg Ser Glu Ser Lys Arg Asn Arg Asp Gly Arg Glu Gly Ile
 1               5                  10                  15      
Leu Glu Gln Trp
            20  


<210> 76
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#2

<400> 76
Asp Gly Arg Glu Gly Ile Leu Glu Gln Trp Val Asn Gly Arg Lys Lys
 1               5                  10                  15      
Leu Glu Asp Leu
            20  


<210> 77
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#3

<400> 77
Val Asn Gly Arg Lys Lys Leu Glu Asp Leu Glu Arg Glu Ala Arg Lys
 1               5                  10                  15      
Ile Lys Lys Lys
            20  


<210> 78
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#4

<400> 78
Glu Arg Glu Ala Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Asp
 1               5                  10                  15      
Glu Asn Pro Trp
            20  


<210> 79
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#5

<400> 79
Ile Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Lys Gly
 1               5                  10                  15      
Ile Leu Gly Lys
            20  


<210> 80
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#6

<400> 80
Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Arg Asp Lys Asp Gly Glu
 1               5                  10                  15      
Gly Ala Pro Pro
            20  


<210> 81
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#7

<400> 81
Arg Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr
 1               5                  10                  15      
Asp Gln Met Glu
            20  


<210> 82
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#8

<400> 82
Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Gly
 1               5                  10                  15      
Lys Arg Pro Leu
            20  


<210> 83
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#9

<400> 83
Ile Asp Ser Gly Pro Gly Lys Arg Pro Leu Arg Gly Gly Phe Ser Asp
 1               5                  10                  15      
Lys Glu Arg Gln
            20  


<210> 84
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#10

<400> 84
Arg Gly Gly Phe Ser Asp Lys Glu Arg Gln Asp His Arg Arg Arg Lys
 1               5                  10                  15      
Ala Leu Glu Asn
            20  


<210> 85
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#11

<400> 85
Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys Gln Leu Ala
 1               5                  10                  15      
Ala Gly Gly Lys
            20  


<210> 86
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#12

<400> 86
Lys Arg Lys Gln Leu Ala Ala Gly Gly Lys His Leu Ser Lys Glu Glu
 1               5                  10                  15      
Glu Glu Glu Leu
            20  


<210> 87
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#13

<400> 87
His Leu Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Glu Glu
 1               5                  10                  15      
Asp Glu Arg Arg
            20  


<210> 88
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#14

<400> 88
Lys Arg Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Thr Ala Gly
 1               5                  10                  15      
Pro Ser Val Gly
            20  


<210> 89
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#15

<400> 89
Glu Arg Arg Thr Ala Gly Pro Ser Val Gly Gly Val Asn Pro Leu Glu
 1               5                  10                  15      
Gly Gly Ser Arg
            20  


<210> 90
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#16

<400> 90
Gly Val Asn Pro Leu Glu Gly Gly Ser Arg Gly Ala Pro Gly Gly Gly
 1               5                  10                  15      
Phe Val Pro Asn
            20  


<210> 91
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#17

<400> 91
Gly Ala Pro Gly Gly Gly Phe Val Pro Asn Met Leu Ser Val Pro Glu
 1               5                  10                  15      
Ser Pro Phe Ser
            20  


<210> 92
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#18

<400> 92
Met Leu Ser Val Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu
 1               5                  10                  15      
Asp Val Arg Gly
            20  


<210> 93
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#19

<400> 93
Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly Phe Pro Trp
 1               5                  10                  15      
Asp Ile Leu Phe
            20  


<210> 94
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#20

<400> 94
Asn Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe
 1               5                  10                  15      
Ser Pro Gln Ser
            20  


<210> 95
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt1-#21

<400> 95
Pro Ala Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln
 1               5                  10                  


<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#1

<400> 96
Met Gly Gln Pro Asp Ser Arg Arg Pro Arg Arg Gly Arg Glu Glu Ser
 1               5                  10                  15      
Leu Gly Lys Trp
            20  


<210> 97
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#2

<400> 97
Arg Gly Arg Glu Glu Ser Leu Gly Lys Trp Ile Asp Ala Arg Arg Arg
 1               5                  10                  15      
Lys Glu Glu Leu
            20  


<210> 98
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#3

<400> 98
Ile Asp Ala Arg Arg Arg Lys Glu Glu Leu Glu Arg Asp Leu Arg Lys
 1               5                  10                  15      
Val Asn Lys Thr
            20  


<210> 99
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#4

<400> 99
Glu Arg Asp Leu Arg Lys Val Asn Lys Thr Ile Lys Arg Leu Glu Glu
 1               5                  10                  15      
Asp Asn Pro Trp
            20  


<210> 100
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#5

<400> 100
Ile Lys Arg Leu Glu Glu Asp Asn Pro Trp Leu Gly Asn Ile Arg Gly
 1               5                  10                  15      
Ile Ile Gly Arg
            20  


<210> 101
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#6

<400> 101
Leu Gly Asn Ile Arg Gly Ile Ile Gly Arg Lys Asp Lys Asp Gly Glu
 1               5                  10                  15      
Gly Ala Pro Pro
            20  


<210> 102
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#7

<400> 102
Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr
 1               5                  10                  15      
Asp Gln Met Glu
            20  


<210> 103
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#8

<400> 103
Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Val Asp Ser Gly Pro Arg
 1               5                  10                  15      
Lys Arg Lys His
            20  


<210> 104
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#9

<400> 104
Val Asp Ser Gly Pro Arg Lys Arg Lys His Pro Gly Gly Phe Thr Glu
 1               5                  10                  15      
Gln Glu Arg Arg
            20  


<210> 105
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#10

<400> 105
Pro Gly Gly Phe Thr Glu Gln Glu Arg Arg Asp His Arg Arg Arg Lys
 1               5                  10                  15      
Ala Leu Glu Asn
            20  


<210> 106
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#11

<400> 106
Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser
 1               5                  10                  15      
Ser Gly Gly Lys
            20  


<210> 107
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#12

<400> 107
Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asp Leu Ser Arg Glu Glu
 1               5                  10                  15      
Glu Glu Glu Leu
            20  


<210> 108
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#13

<400> 108
Asp Leu Ser Arg Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Glu Glu
 1               5                  10                  15      
Asp Glu Arg Arg
            20  


<210> 109
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#14

<400> 109
Arg Arg Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala Gly
 1               5                  10                  15      
Pro Arg Val Gly
            20  


<210> 110
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#15

<400> 110
Glu Arg Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Leu Asp
 1               5                  10                  15      
Gly Gly Pro Arg
            20  


<210> 111
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#16

<400> 111
Asp Val Asn Pro Leu Asp Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly
 1               5                  10                  15      
Phe Val Pro Ser
            20  


<210> 112
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#17

<400> 112
Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu
 1               5                  10                  15      
Ser Pro Phe Thr
            20  


<210> 113
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#18

<400> 113
Met Gln Gly Ile Pro Glu Ser Pro Phe Thr Arg Arg Gly Asp Gly Leu
 1               5                  10                  15      
Asp Thr Arg Gly
            20  


<210> 114
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#19

<400> 114
Arg Arg Gly Asp Gly Leu Asp Thr Arg Gly Thr Gln Glu Phe Pro Trp
 1               5                  10                  15      
Val Asn Pro Gln
            20  


<210> 115
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#20

<400> 115
Thr Gln Glu Phe Pro Trp Val Asn Pro Gln Pro Pro Pro Pro Arg Leu
 1               5                  10                  15      
Pro Leu Leu Glu
            20  


<210> 116
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> L-HDAg-gt2-#21

<400> 116
Pro Pro Pro Pro Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln
 1               5                  10                  

