
                                SEQUENCE LISTING

<110> The Board of Trustees of the Leland Stanford Junior University
      Iyer, Shrivats Mohan
      Delp, Scott L.

<120> Designer Receptors for Modulating Pain
  and Methods of Use Thereof
  

<130> STAN-1279WO

<150> US 62/288,865       
<151> 2016-01-29  

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 590
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 1
Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile
 1               5                  10                  15      
Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly
            20                  25                  30          
Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn
        35                  40                  45              
Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr
    50                  55                  60                  
Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu
65                  70                  75                  80  
Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn
                85                  90                  95      
Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys
            100                 105                 110         
Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr
        115                 120                 125             
Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp
    130                 135                 140                 
Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu
145                 150                 155                 160 
Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr
                165                 170                 175     
Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala
            180                 185                 190         
Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln
        195                 200                 205             
Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln
    210                 215                 220                 
Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe
225                 230                 235                 240 
Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys
                245                 250                 255     
Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly
            260                 265                 270         
Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg
        275                 280                 285             
Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn
    290                 295                 300                 
Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp
305                 310                 315                 320 
Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser
                325                 330                 335     
Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser
            340                 345                 350         
Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val
        355                 360                 365             
Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro
    370                 375                 380                 
Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp
385                 390                 395                 400 
Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp
                405                 410                 415     
Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu
            420                 425                 430         
Ser Ala Val Asp Thr Ala Lys Thr Ser Asp Val Asn Ser Ser Val Gly
        435                 440                 445             
Lys Ser Thr Ala Thr Leu Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala
    450                 455                 460                 
Lys Arg Phe Ala Leu Lys Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg
465                 470                 475                 480 
Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala Ile
                485                 490                 495     
Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu
            500                 505                 510         
Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn Leu
        515                 520                 525             
Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys Tyr
    530                 535                 540                 
Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu Leu
545                 550                 555                 560 
Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg
                565                 570                 575     
Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu
            580                 585                 590 


<210> 2
<211> 590
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 2
Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile
 1               5                  10                  15      
Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly
            20                  25                  30          
Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn
        35                  40                  45              
Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr
    50                  55                  60                  
Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu
65                  70                  75                  80  
Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn
                85                  90                  95      
Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys
            100                 105                 110         
Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr
        115                 120                 125             
Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp
    130                 135                 140                 
Leu Ala Ile Asp Cys Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu
145                 150                 155                 160 
Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr
                165                 170                 175     
Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala
            180                 185                 190         
Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln
        195                 200                 205             
Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln
    210                 215                 220                 
Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Gly Phe
225                 230                 235                 240 
Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys
                245                 250                 255     
Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly
            260                 265                 270         
Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg
        275                 280                 285             
Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn
    290                 295                 300                 
Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp
305                 310                 315                 320 
Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser
                325                 330                 335     
Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser
            340                 345                 350         
Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val
        355                 360                 365             
Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro
    370                 375                 380                 
Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp
385                 390                 395                 400 
Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp
                405                 410                 415     
Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu
            420                 425                 430         
Ser Ala Val Asp Thr Ala Lys Thr Ser Asp Val Asn Ser Ser Val Gly
        435                 440                 445             
Lys Ser Thr Ala Thr Leu Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala
    450                 455                 460                 
Lys Arg Phe Ala Leu Lys Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg
465                 470                 475                 480 
Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala Ile
                485                 490                 495     
Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu
            500                 505                 510         
Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn Leu
        515                 520                 525             
Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys Tyr
    530                 535                 540                 
Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu Leu
545                 550                 555                 560 
Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg
                565                 570                 575     
Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu
            580                 585                 590 


<210> 3
<211> 479
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 3
Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val
 1               5                  10                  15      
Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met
            20                  25                  30          
Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val
        35                  40                  45              
Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln
    50                  55                  60                  
Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile
65                  70                  75                  80  
Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly
                85                  90                  95      
Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp
            100                 105                 110         
Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe
        115                 120                 125             
Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg
    130                 135                 140                 
Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser
145                 150                 155                 160 
Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly
                165                 170                 175     
Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn
            180                 185                 190         
Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro Val
        195                 200                 205             
Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser
    210                 215                 220                 
Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys
225                 230                 235                 240 
Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys
                245                 250                 255     
Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu
            260                 265                 270         
Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala
        275                 280                 285             
Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn
    290                 295                 300                 
Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr
305                 310                 315                 320 
Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala
                325                 330                 335     
Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu
            340                 345                 350         
Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg
        355                 360                 365             
Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln
    370                 375                 380                 
Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg
385                 390                 395                 400 
Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr
                405                 410                 415     
Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp
            420                 425                 430         
Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile
        435                 440                 445             
Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe
    450                 455                 460                 
Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg
465                 470                 475                 


<210> 4
<211> 479
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 4
Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val
 1               5                  10                  15      
Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met
            20                  25                  30          
Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val
        35                  40                  45              
Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln
    50                  55                  60                  
Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile
65                  70                  75                  80  
Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly
                85                  90                  95      
Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp
            100                 105                 110         
Cys Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe
        115                 120                 125             
Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg
    130                 135                 140                 
Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser
145                 150                 155                 160 
Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly
                165                 170                 175     
Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn
            180                 185                 190         
Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Leu Pro Val
        195                 200                 205             
Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser
    210                 215                 220                 
Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys
225                 230                 235                 240 
Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys
                245                 250                 255     
Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu
            260                 265                 270         
Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala
        275                 280                 285             
Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn
    290                 295                 300                 
Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr
305                 310                 315                 320 
Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala
                325                 330                 335     
Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu
            340                 345                 350         
Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg
        355                 360                 365             
Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln
    370                 375                 380                 
Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg
385                 390                 395                 400 
Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr
                405                 410                 415     
Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp
            420                 425                 430         
Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile
        435                 440                 445             
Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe
    450                 455                 460                 
Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg
465                 470                 475                 

