                         SEQUENCE LISTING

<110>  RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL 
       SCIENCES
       NEUFELD, Gera
       MUMBLAT, Yelena
       KESSLER, Ofra
 
<120>  SEMAPHORIN 3C VARIANTS, COMPOSITIONS COMPRISING SAID VARIANTS AND
        METHODS OF USE THEREOF

<130>  P-79724-PC

<150>  61/875,060
<151>  2013-09-08

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     


<210>  2
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Gly Arg Arg 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Ser Arg Arg 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Asn Arg Arg 
1               


<210>  5
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile Asn Ser Arg 
1               5                   10                  15      


Lys Ser Arg Asn Arg Arg 
            20          


<210>  6
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg 
545             


<210>  7
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Leu Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                565                 570                 575     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            580                 585                 590         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        595                 600                 605             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    610                 615                 620                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
625                 630                 635                 640 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                645                 650                 655     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            660                 665                 670         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        675                 680                 685             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    690                 695                 700                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                725                 730                 735     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            740                 745                 750         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        755                 760                 765             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775         


<210>  8
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Lys Ser Lys Lys Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Leu Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            740                 745                 750         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        755                 760                 765             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    770                 775                 780                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
785                 790                 795                 800 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                805                 810                 815     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            820                 825                 830         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        835                 840                 845             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    850                 855                 860                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
865                 870                 875                 880 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                885                 890                 895     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            900                 905                 910         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        915                 920                 925             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    930                 935                 940                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
945                 950                 955                 960 


Leu Ser Leu Ser Pro Gly Lys 
                965         


<210>  9
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Lys Ser Lys Lys Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Leu Glu Ser Arg Gly Pro Phe Glu Gln Lys Leu Ile Ser Glu 
            740                 745                 750         


Glu Asp Leu Asn Met His Thr Gly His His His His His His 
        755                 760                 765     


<210>  10
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Lys Ser Lys Lys Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     


<210>  11
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Ser Lys Arg 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  12

Lys Ser Lys Arg 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Ser Lys Lys 
1               


<210>  14
<211>  980
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser Leu 
            740                 745                 750         


Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        755                 760                 765             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    770                 775                 780                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
785                 790                 795                 800 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                805                 810                 815     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            820                 825                 830         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        835                 840                 845             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    850                 855                 860                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
865                 870                 875                 880 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                885                 890                 895     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            900                 905                 910         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        915                 920                 925             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    930                 935                 940                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
945                 950                 955                 960 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                965                 970                 975     


Ser Pro Gly Lys 
            980 


<210>  15
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  15
atggcattcc ggacaatttg cgtgttggtt ggagtattta tttgttctat ctgtgtgaaa       60

ggatcttccc agccccaagc aagagtttat ttaacatttg atgaacttcg agaaaccaag      120

acctctgaat acttcagcct ttcccaccat cctttagact acaggatttt attaatggat      180

gaagatcagg accggatata tgtgggaagc aaagatcaca ttctttccct gaatattaac      240

aatataagtc aagaagcttt gagtgttttc tggccagcat ctacaatcaa agttgaagaa      300

tgcaaaatgg ctggcaaaga tcccacacac ggctgtggga actttgtccg tgtaattcag      360

actttcaatc gcacacattt gtatgtctgt gggagtggcg ctttcagtcc tgtctgtact      420

tacttgaaca gagggaggag atcagaggac caagttttca tgattgactc caagtgtgaa      480

tctggaaaag gacgctgctc tttcaacccc aacgtgaaca cggtgtctgt tatgatcaat      540

gaggagcttt tctctggaat gtatatagat ttcatgggga cagatgctgc tatttttcga      600

agtttaacca agaggaatgc ggtcagaact gatcaacata attccaaatg gctaagtgaa      660

cctatgtttg tagatgcaca tgtcatccca gatggtactg atccaaatga tgctaaggtg      720

tacttcttct tcaaagaaaa actgactgac aataacagga gcacgaaaca gattcattcc      780

atgattgctc gaatatgtcc taatgacact ggtggactgc gtagccttgt caacaagtgg      840

accactttct taaaggcgag gctggtgtgc tcggtaacag atgaagacgg cccagaaaca      900

cactttgatg aattagagga tgtgtttctg ctggaaactg ataacccgag gacaacacta      960

gtgtatggca tttttacaac atcaagctca gttttcaaag gatcagccgt gtgtgtgtat     1020

catttatctg atatacagac tgtgtttaat gggccttttg cccacaaaga agggcccaat     1080

catcagctga tttcctatca gggcagaatt ccatatcctc gccctggaac ttgtccagga     1140

ggagcattta cacccaatat gcgaaccacc aaggagttcc cagatgatgt tgtcactttt     1200

attcggaacc atcctctcat gtacaattcc atctacccaa tccacaaaag gcctttgatt     1260

gttcgtattg gcactgacta caagtataca aagatagctg tggatcgagt gaacgctgct     1320

gatgggagat accatgtcct gtttctcgga acagatcggg gtactgtgca aaaagtggtt     1380

gttcttccta ctaacaactc tgtcagtggc gagctcattc tggaggagct ggaagtcttt     1440

aagaatcatg ctcctataac aacaatgaaa atttcatcta aaaagcaaca gttgtatgtg     1500

agttccaatg aaggggtttc ccaggtatct ctgcaccgct gccacatcta tggtacagcc     1560

tgtgctgact gctgcctggc gcgggaccct tattgcgcct gggatggcca ttcctgttcc     1620

agattctacc caactgggaa acggaggagc cgaagacaag atgtgagaca tggaaaccca     1680

ctgactcaat gcagaggatt taatctaaaa gcatacagaa atgcagctga aattgtgcag     1740

tatggagtaa aaaataacac cacttttctg gagtgtgccc ccaagtctcc gcaggcatct     1800

atcaagtggc tgttacagaa agacaaagac aggaggaaag aggttaagct gaatgaacga     1860

ataatagcca cttcacaggg actcctgatc cgctctgttc agggttctga ccaaggactt     1920

tatcactgca ttgctacaga aaatagtttc aagcagacca tagccaagat caacttcaaa     1980

gttttagatt cagaaatggt ggctgttgtg acggacaaat ggtccccatg gacctgggcc     2040

agctctgtga gggctttacc cttccacccg aaggacatca tgggggcatt cagccactca     2100

gaaatgcaga tgattaacca atattgcaaa gacactcggc agcaacatca gcagggagat     2160

gaatcacaga aaatgagagg ggactatggc aagttaaagg ccctcatcaa tagtcggaaa     2220

agtagaaaca ggaggaatca gttgccagag tcataa                               2256


<210>  16
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  16
agagggagga ga                                                           12


<210>  17
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  17
aggagccgaa ga                                                           12


<210>  18
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  18
agaaacagga gg                                                           12


<210>  19
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  19
aaaatgagag gggactatgg caagttaaag gccctcatca atagtcggaa aagtagaaac       60

aggagg                                                                  66


<210>  20
<211>  1644
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcattcc ggacaatttg cgtgttggtt ggagtattta tttgttctat ctgtgtgaaa       60

ggatcttccc agccccaagc aagagtttat ttaacatttg atgaacttcg agaaaccaag      120

acctctgaat acttcagcct ttcccaccat cctttagact acaggatttt attaatggat      180

gaagatcagg accggatata tgtgggaagc aaagatcaca ttctttccct gaatattaac      240

aatataagtc aagaagcttt gagtgttttc tggccagcat ctacaatcaa agttgaagaa      300

tgcaaaatgg ctggcaaaga tcccacacac ggctgtggga actttgtccg tgtaattcag      360

actttcaatc gcacacattt gtatgtctgt gggagtggcg ctttcagtcc tgtctgtact      420

tacttgaaca gagggaggag atcagaggac caagttttca tgattgactc caagtgtgaa      480

tctggaaaag gacgctgctc tttcaacccc aacgtgaaca cggtgtctgt tatgatcaat      540

gaggagcttt tctctggaat gtatatagat ttcatgggga cagatgctgc tatttttcga      600

agtttaacca agaggaatgc ggtcagaact gatcaacata attccaaatg gctaagtgaa      660

cctatgtttg tagatgcaca tgtcatccca gatggtactg atccaaatga tgctaaggtg      720

tacttcttct tcaaagaaaa actgactgac aataacagga gcacgaaaca gattcattcc      780

atgattgctc gaatatgtcc taatgacact ggtggactgc gtagccttgt caacaagtgg      840

accactttct taaaggcgag gctggtgtgc tcggtaacag atgaagacgg cccagaaaca      900

cactttgatg aattagagga tgtgtttctg ctggaaactg ataacccgag gacaacacta      960

gtgtatggca tttttacaac atcaagctca gttttcaaag gatcagccgt gtgtgtgtat     1020

catttatctg atatacagac tgtgtttaat gggccttttg cccacaaaga agggcccaat     1080

catcagctga tttcctatca gggcagaatt ccatatcctc gccctggaac ttgtccagga     1140

ggagcattta cacccaatat gcgaaccacc aaggagttcc cagatgatgt tgtcactttt     1200

attcggaacc atcctctcat gtacaattcc atctacccaa tccacaaaag gcctttgatt     1260

gttcgtattg gcactgacta caagtataca aagatagctg tggatcgagt gaacgctgct     1320

gatgggagat accatgtcct gtttctcgga acagatcggg gtactgtgca aaaagtggtt     1380

gttcttccta ctaacaactc tgtcagtggc gagctcattc tggaggagct ggaagtcttt     1440

aagaatcatg ctcctataac aacaatgaaa atttcatcta aaaagcaaca gttgtatgtg     1500

agttccaatg aaggggtttc ccaggtatct ctgcaccgct gccacatcta tggtacagcc     1560

tgtgctgact gctgcctggc gcgggaccct tattgcgcct gggatggcca ttcctgttcc     1620

agattctacc caactgggaa acgg                                            1644


<210>  21
<211>  2334
<212>  DNA
<213>  Homo sapiens

<400>  21
atggcattcc ggacaatttg cgtgttggtt ggagtattta tttgttctat ctgtgtgaaa       60

ggatcttccc agccccaagc aagagtttat ttaacatttg atgaacttcg agaaaccaag      120

acctctgaat acttcagcct ttcccaccat cctttagact acaggatttt attaatggat      180

gaagatcagg accggatata tgtgggaagc aaagatcaca ttctttccct gaatattaac      240

aatataagtc aagaagcttt gagtgttttc tggccagcat ctacaatcaa agttgaagaa      300

tgcaaaatgg ctggcaaaga tcccacacac ggctgtggga actttgtccg tgtaattcag      360

actttcaatc gcacacattt gtatgtctgt gggagtggcg ctttcagtcc tgtctgtact      420

tacttgaaca gagggaggag atcagaggac caagttttca tgattgactc caagtgtgaa      480

tctggaaaag gacgctgctc tttcaacccc aacgtgaaca cggtgtctgt tatgatcaat      540

gaggagcttt tctctggaat gtatatagat ttcatgggga cagatgctgc tatttttcga      600

agtttaacca agaggaatgc ggtcagaact gatcaacata attccaaatg gctaagtgaa      660

cctatgtttg tagatgcaca tgtcatccca gatggtactg atccaaatga tgctaaggtg      720

tacttcttct tcaaagaaaa actgactgac aataacagga gcacgaaaca gattcattcc      780

atgattgctc gaatatgtcc taatgacact ggtggactgc gtagccttgt caacaagtgg      840

accactttct taaaggcgag gctggtgtgc tcggtaacag atgaagacgg cccagaaaca      900

cactttgatg aattagagga tgtgtttctg ctggaaactg ataacccgag gacaacacta      960

gtgtatggca tttttacaac atcaagctca gttttcaaag gatcagccgt gtgtgtgtat     1020

catttatctg atatacagac tgtgtttaat gggccttttg cccacaaaga agggcccaat     1080

catcagctga tttcctatca gggcagaatt ccatatcctc gccctggaac ttgtccagga     1140

ggagcattta cacccaatat gcgaaccacc aaggagttcc cagatgatgt tgtcactttt     1200

attcggaacc atcctctcat gtacaattcc atctacccaa tccacaaaag gcctttgatt     1260

gttcgtattg gcactgacta caagtataca aagatagctg tggatcgagt gaacgctgct     1320

gatgggagat accatgtcct gtttctcgga acagatcggg gtactgtgca aaaagtggtt     1380

gttcttccta ctaacaactc tgtcagtggc gagctcattc tggaggagct ggaagtcttt     1440

aagaatcatg ctcctataac aacaatgaaa atttcatcta aaaagcaaca gttgtatgtg     1500

agttccaatg aaggggtttc ccaggtatct ctgcaccgct gccacatcta tggtacagcc     1560

tgtgctgact gctgcctggc gcgggaccct tattgcgcct gggatggcca ttcctgttcc     1620

agattctacc caactgggaa acggctcgag gacaaaactc acacatgccc accgtgccca     1680

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1740

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1800

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1860

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1920

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1980

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     2040

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     2100

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     2160

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     2220

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     2280

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa atga           2334


<210>  22
<211>  2904
<212>  DNA
<213>  Homo sapiens

<400>  22
atggcattcc ggacaatttg cgtgttggtt ggagtattta tttgttctat ctgtgtgaaa       60

ggatcttccc agccccaagc aagagtttat ttaacatttg atgaacttcg agaaaccaag      120

acctctgaat acttcagcct ttcccaccat cctttagact acaggatttt attaatggat      180

gaagatcagg accggatata tgtgggaagc aaagatcaca ttctttccct gaatattaac      240

aatataagtc aagaagcttt gagtgttttc tggccagcat ctacaatcaa agttgaagaa      300

tgcaaaatgg ctggcaaaga tcccacacac ggctgtggga actttgtccg tgtaattcag      360

actttcaatc gcacacattt gtatgtctgt gggagtggcg ctttcagtcc tgtctgtact      420

tacttgaaca gagggaggag atcagaggac caagttttca tgattgactc caagtgtgaa      480

tctggaaaag gacgctgctc tttcaacccc aacgtgaaca cggtgtctgt tatgatcaat      540

gaggagcttt tctctggaat gtatatagat ttcatgggga cagatgctgc tatttttcga      600

agtttaacca agaggaatgc ggtcagaact gatcaacata attccaaatg gctaagtgaa      660

cctatgtttg tagatgcaca tgtcatccca gatggtactg atccaaatga tgctaaggtg      720

tacttcttct tcaaagaaaa actgactgac aataacagga gcacgaaaca gattcattcc      780

atgattgctc gaatatgtcc taatgacact ggtggactgc gtagccttgt caacaagtgg      840

accactttct taaaggcgag gctggtgtgc tcggtaacag atgaagacgg cccagaaaca      900

cactttgatg aattagagga tgtgtttctg ctggaaactg ataacccgag gacaacacta      960

gtgtatggca tttttacaac atcaagctca gttttcaaag gatcagccgt gtgtgtgtat     1020

catttatctg atatacagac tgtgtttaat gggccttttg cccacaaaga agggcccaat     1080

catcagctga tttcctatca gggcagaatt ccatatcctc gccctggaac ttgtccagga     1140

ggagcattta cacccaatat gcgaaccacc aaggagttcc cagatgatgt tgtcactttt     1200

attcggaacc atcctctcat gtacaattcc atctacccaa tccacaaaag gcctttgatt     1260

gttcgtattg gcactgacta caagtataca aagatagctg tggatcgagt gaacgctgct     1320

gatgggagat accatgtcct gtttctcgga acagatcggg gtactgtgca aaaagtggtt     1380

gttcttccta ctaacaactc tgtcagtggc gagctcattc tggaggagct ggaagtcttt     1440

aagaatcatg ctcctataac aacaatgaaa atttcatcta aaaagcaaca gttgtatgtg     1500

agttccaatg aaggggtttc ccaggtatct ctgcaccgct gccacatcta tggtacagcc     1560

tgtgctgact gctgcctggc gcgggaccct tattgcgcct gggatggcca ttcctgttcc     1620

agattctacc caactgggaa acggaagagc aaaaaacaag atgtgagaca tggaaaccca     1680

ctgactcaat gcagaggatt taatctaaaa gcatacagaa atgcagctga aattgtgcag     1740

tatggagtaa aaaataacac cacttttctg gagtgtgccc ccaagtctcc gcaggcatct     1800

atcaagtggc tgttacagaa agacaaagac aggaggaaag aggttaagct gaatgaacga     1860

ataatagcca cttcacaggg actcctgatc cgctctgttc agggttctga ccaaggactt     1920

tatcactgca ttgctacaga aaatagtttc aagcagacca tagccaagat caacttcaaa     1980

gttttagatt cagaaatggt ggctgttgtg acggacaaat ggtccccatg gacctgggcc     2040

agctctgtga gggctttacc cttccacccg aaggacatca tgggggcatt cagccactca     2100

gaaatgcaga tgattaacca atattgcaaa gacactcggc agcaacatca gcagggagat     2160

gaatcacaga aaatgagagg ggactatggc aagttaaagg ccctcatcaa tagtctcgag     2220

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     2280

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     2340

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2400

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2460

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2520

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2580

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     2640

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2700

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2760

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     2820

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2880

ctctccctgt ccccgggtaa atga                                            2904


<210>  23
<211>  2301
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcattcc ggacaatttg cgtgttggtt ggagtattta tttgttctat ctgtgtgaaa       60

ggatcttccc agccccaagc aagagtttat ttaacatttg atgaacttcg agaaaccaag      120

acctctgaat acttcagcct ttcccaccat cctttagact acaggatttt attaatggat      180

gaagatcagg accggatata tgtgggaagc aaagatcaca ttctttccct gaatattaac      240

aatataagtc aagaagcttt gagtgttttc tggccagcat ctacaatcaa agttgaagaa      300

tgcaaaatgg ctggcaaaga tcccacacac ggctgtggga actttgtccg tgtaattcag      360

actttcaatc gcacacattt gtatgtctgt gggagtggcg ctttcagtcc tgtctgtact      420

tacttgaaca gagggaggag atcagaggac caagttttca tgattgactc caagtgtgaa      480

tctggaaaag gacgctgctc tttcaacccc aacgtgaaca cggtgtctgt tatgatcaat      540

gaggagcttt tctctggaat gtatatagat ttcatgggga cagatgctgc tatttttcga      600

agtttaacca agaggaatgc ggtcagaact gatcaacata attccaaatg gctaagtgaa      660

cctatgtttg tagatgcaca tgtcatccca gatggtactg atccaaatga tgctaaggtg      720

tacttcttct tcaaagaaaa actgactgac aataacagga gcacgaaaca gattcattcc      780

atgattgctc gaatatgtcc taatgacact ggtggactgc gtagccttgt caacaagtgg      840

accactttct taaaggcgag gctggtgtgc tcggtaacag atgaagacgg cccagaaaca      900

cactttgatg aattagagga tgtgtttctg ctggaaactg ataacccgag gacaacacta      960

gtgtatggca tttttacaac atcaagctca gttttcaaag gatcagccgt gtgtgtgtat     1020

catttatctg atatacagac tgtgtttaat gggccttttg cccacaaaga agggcccaat     1080

catcagctga tttcctatca gggcagaatt ccatatcctc gccctggaac ttgtccagga     1140

ggagcattta cacccaatat gcgaaccacc aaggagttcc cagatgatgt tgtcactttt     1200

attcggaacc atcctctcat gtacaattcc atctacccaa tccacaaaag gcctttgatt     1260

gttcgtattg gcactgacta caagtataca aagatagctg tggatcgagt gaacgctgct     1320

gatgggagat accatgtcct gtttctcgga acagatcggg gtactgtgca aaaagtggtt     1380

gttcttccta ctaacaactc tgtcagtggc gagctcattc tggaggagct ggaagtcttt     1440

aagaatcatg ctcctataac aacaatgaaa atttcatcta aaaagcaaca gttgtatgtg     1500

agttccaatg aaggggtttc ccaggtatct ctgcaccgct gccacatcta tggtacagcc     1560

tgtgctgact gctgcctggc gcgggaccct tattgcgcct gggatggcca ttcctgttcc     1620

agattctacc caactgggaa acggaagagc aaaaaacaag atgtgagaca tggaaaccca     1680

ctgactcaat gcagaggatt taatctaaaa gcatacagaa atgcagctga aattgtgcag     1740

tatggagtaa aaaataacac cacttttctg gagtgtgccc ccaagtctcc gcaggcatct     1800

atcaagtggc tgttacagaa agacaaagac aggaggaaag aggttaagct gaatgaacga     1860

ataatagcca cttcacaggg actcctgatc cgctctgttc agggttctga ccaaggactt     1920

tatcactgca ttgctacaga aaatagtttc aagcagacca tagccaagat caacttcaaa     1980

gttttagatt cagaaatggt ggctgttgtg acggacaaat ggtccccatg gacctgggcc     2040

agctctgtga gggctttacc cttccacccg aaggacatca tgggggcatt cagccactca     2100

gaaatgcaga tgattaacca atattgcaaa gacactcggc agcaacatca gcagggagat     2160

gaatcacaga aaatgagagg ggactatggc aagttaaagg ccctcatcaa tagtctcgag     2220

tctagagggc ccttcgaaca aaaactcatc tcagaagagg atctgaatat gcataccggt     2280

catcatcacc atcaccattg a                                               2301


<210>  24
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  24
gggaaacgga ggagcaaaag acaagatgtg agacatgg                               38


<210>  25
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  25
ccatgtctca catcttgtct tttgctcctc cgtttccc                               38


<210>  26
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  26
tacccaactg ggaaacggaa gagcaaaaga caagatgtga gacatgg                     47


<210>  27
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  27
ccatgtctca catcttgtct tttgctcttc cgtttcccag ttgggta                     47


<210>  28
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  28
gggaaacgga agagcaaaaa acaagatgtg agacatggaa accc                        44


<210>  29
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  29
gggtttccat gtctcacatc ttgttttttg ctcttccgtt tccc                        44


<210>  30
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  30
cgggatccac catggcatcg gacaatttg                                         29


<210>  31
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  31
cgctcgagac tattgatgag ggcctttaac tt                                     32


<210>  32
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  32
cggaaaagta gaaacaggag gaatcagttg ccagagtcat aa                          42


<210>  33
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser 
        


<210>  34
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
1               5                   10              


<210>  35
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Lys Ser Lys Lys Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser 
        


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
1               5                   10  


