                         SEQUENCE LISTING

<110>  Philip Morris Products S.A.
 
<120>  Reducing cadmium accumulation in field grown plants

<130>  P10255EP

<140>  EP16153529.9
<141>  2016-01-29

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1403
<212>  PRT
<213>  Nicotiana tabacum

<400>  1

Met Val Glu Ser Glu Lys Met Asn Glu Thr Lys Lys Leu Ser Lys Ser 
1               5                   10                  15      


Tyr Phe Asp Val Leu Gly Ile Cys Cys Thr Ser Glu Val Val Leu Val 
            20                  25                  30          


Glu Lys Ile Leu Lys Asn Leu Glu Gly Val Lys Glu Val Ser Val Ile 
        35                  40                  45              


Val Thr Thr Lys Thr Val Ile Val Ile His Asp Ser Leu Leu Ile Ser 
    50                  55                  60                  


Pro Gln Gln Ile Val Lys Ala Leu Asn Gln Ala Arg Leu Glu Ala Ser 
65                  70                  75                  80  


Ile Arg Val Lys Gly Glu Lys Asn Tyr Gln Lys Lys Trp Pro Ser Pro 
                85                  90                  95      


Phe Ala Ile Gly Ser Gly Ile Leu Leu Gly Leu Ser Phe Leu Lys Tyr 
            100                 105                 110         


Phe Phe Ala Pro Phe Gln Trp Leu Ala Leu Ala Ala Val Ala Val Gly 
        115                 120                 125             


Ile Pro Pro Ile Ile Phe Arg Gly Val Ala Ala Val Arg Asn Leu Thr 
    130                 135                 140                 


Leu Asp Ile Asn Ile Leu Val Leu Ile Ala Val Ala Gly Ser Ile Val 
145                 150                 155                 160 


Leu His Asp Tyr Trp Glu Ala Gly Thr Ile Val Phe Leu Phe Ala Ile 
                165                 170                 175     


Ala Glu Trp Leu Glu Ser Arg Ala Ser His Lys Ala Thr Ala Ala Met 
            180                 185                 190         


Ser Ser Leu Val Asn Ile Val Pro Pro Thr Ala Val Leu Ala Glu Ser 
        195                 200                 205             


Gly Glu Val Val Asn Val Asp Glu Val Lys Val Asn Ser Ile Leu Ala 
    210                 215                 220                 


Val Lys Ala Gly Glu Thr Ile Pro Ile Asp Gly Val Val Val Glu Gly 
225                 230                 235                 240 


Glu Cys Asp Val Asp Glu Lys Thr Leu Thr Gly Glu Ser Phe Pro Val 
                245                 250                 255     


Ser Lys Gln Arg Asp Ser Thr Val Trp Ala Gly Thr Thr Asn Leu Asn 
            260                 265                 270         


Gly Tyr Ile Ser Val Lys Thr Thr Ala Leu Ala Glu Asp Cys Ala Val 
        275                 280                 285             


Ala Arg Met Ala Gln Leu Val Glu Asp Ala Gln Asn Lys Lys Ser Lys 
    290                 295                 300                 


Thr Gln Arg Tyr Ile Asp Lys Cys Ala Lys Tyr Tyr Thr Pro Ala Ile 
305                 310                 315                 320 


Val Ala Ile Ser Ala Ser Leu Ala Ile Val Pro Thr Ala Leu Arg Val 
                325                 330                 335     


His Asn Arg Asn Glu Trp Tyr Arg Leu Ala Leu Val Thr Leu Val Ser 
            340                 345                 350         


Ala Cys Pro Cys Ala Leu Val Leu Ser Thr Pro Val Ala Met Cys Cys 
        355                 360                 365             


Ala Leu Ser Lys Ala Ala Thr Ser Gly Leu Leu Phe Lys Gly Ala Glu 
    370                 375                 380                 


Tyr Leu Glu Thr Leu Ala Lys Ile Lys Ile Met Ala Phe Asp Lys Thr 
385                 390                 395                 400 


Gly Thr Ile Thr Lys Gly Glu Phe Met Val Thr Glu Phe Lys Ser Leu 
                405                 410                 415     


Ile Asp Gly Phe Ser Leu Asn Thr Leu Leu Tyr Trp Val Ser Ser Ile 
            420                 425                 430         


Glu Ser Lys Ser Gly His Pro Met Ala Ala Ala Leu Val Asp Tyr Ala 
        435                 440                 445             


Gln Ser Asn Ser Val Glu Pro Lys Pro Asp Arg Val Glu Gln Phe Gln 
    450                 455                 460                 


Asn Phe Pro Gly Glu Gly Ile Phe Gly Arg Ile Asp Gly Met Glu Ile 
465                 470                 475                 480 


Tyr Val Gly Asn Arg Lys Ile Ser Ser Arg Ala Gly Cys Thr Thr Val 
                485                 490                 495     


Pro Glu Ile Glu Gly Asp Ser Phe Lys Gly Lys Ser Val Gly Tyr Ile 
            500                 505                 510         


Phe Leu Gly Ser Ser Pro Ala Gly Ile Phe Ser Leu Ser Asp Val Cys 
        515                 520                 525             


Arg Ile Gly Val Lys Glu Ala Met Arg Glu Leu Lys Gln Met Gly Ile 
    530                 535                 540                 


Lys Thr Ala Met Leu Thr Gly Asp Cys Tyr Ala Ala Ala Asn His Val 
545                 550                 555                 560 


Gln Asp Gln Leu Gly Gly Ala Leu Asp Glu Phe Gln Ala Glu Leu Leu 
                565                 570                 575     


Pro Glu Asp Lys Ala Thr Ile Ile Lys Gly Phe Gln Lys Glu Ala Pro 
            580                 585                 590         


Thr Ala Met Ile Gly Asp Gly Leu Asn Asp Ala Pro Ala Leu Ala Thr 
        595                 600                 605             


Ala Asp Ile Gly Ile Ser Met Gly Ile Ser Gly Ser Ala Leu Ala Lys 
    610                 615                 620                 


Glu Thr Gly His Val Ile Leu Met Thr Asn Asp Ile Gly Arg Ile Pro 
625                 630                 635                 640 


Lys Ala Ala Arg Leu Ala Arg Arg Val Arg Arg Lys Ile Val Glu Asn 
                645                 650                 655     


Met Ile Ile Ser Val Val Thr Lys Ala Ala Ile Val Ala Leu Ala Ile 
            660                 665                 670         


Ala Gly Tyr Pro Leu Val Trp Ala Ala Val Leu Ala Asp Thr Gly Thr 
        675                 680                 685             


Cys Leu Leu Val Ile Leu Asn Ser Met Leu Leu Leu Arg Gly Gly Thr 
    690                 695                 700                 


Arg Arg His Gly Lys Lys Cys Trp Arg Ser Ser Thr Pro Ser His Ala 
705                 710                 715                 720 


Pro His His Lys Asp Lys Ala Ser Cys Cys Lys Ser Glu Asn Ala Pro 
                725                 730                 735     


Gln Leu Cys Cys Ser Asp Ile Glu Ser Gln Lys Lys Cys Thr Ser Gln 
            740                 745                 750         


Ser Cys Ser Ser Glu Val Cys Val Pro Arg Cys Gln Pro Val Ser Ser 
        755                 760                 765             


Gly Ser Lys Ser Cys Gly Asn Asn Gln Cys Pro Asp Ser Ile Glu Asn 
    770                 775                 780                 


Ser Gly Phe His Ser His Arg Arg Pro Gln Cys Cys Ser Ser Lys Met 
785                 790                 795                 800 


Ala Ala Lys Ala Cys Gln Ser Ala Val Ser Glu Ser Lys Ser Cys Gly 
                805                 810                 815     


Asn Asn Gln Cys Pro Asp Ser Val Glu Asn Ser Gly Phe His Ser His 
            820                 825                 830         


Pro Arg Pro Glu Cys Cys Ser Ser Lys Met Ala Ala Lys Ala Cys Gln 
        835                 840                 845             


Ser Ala Val Ser Glu Ser Lys Ser Cys Gly Asn Asn Gln Cys Pro Asp 
    850                 855                 860                 


Ser Val Glu Asn Ser Gly Phe His Ser His Pro Arg Pro Gln Cys Cys 
865                 870                 875                 880 


Ser Ser Lys Met Ala Ala Lys Ala Gly Gln Ser Ala Leu Ser Glu Ser 
                885                 890                 895     


Lys Ser Cys Gly Asn Asn Asn Cys Ser Asp Ser Ile His Lys Ser Asn 
            900                 905                 910         


Cys His Ser Leu Thr Asn Ser Leu Val Cys Ser Ser Lys Met Ser Ala 
        915                 920                 925             


Pro Gln Cys His Ser Ala Thr Ser Ser Asn Lys Ser Cys Gly Ser Thr 
    930                 935                 940                 


Lys Cys Ser Asp Phe Ser Asp Lys Lys Cys Cys Gln Ser Asp Lys Ile 
945                 950                 955                 960 


Pro Gln Thr Cys Ser Thr Lys Lys Ser Ala Pro Gly Cys Gln Ser Ala 
                965                 970                 975     


Val Ser Gly Ser Lys Ser Cys Gly Asn Ser Lys Cys Ser Asp Ser Lys 
            980                 985                 990         


Asp Asn Ser Ser His Pro Ser His  Pro Asp His Gln Thr  Cys Met Ser 
        995                 1000                 1005             


Lys Leu  Cys Ala Pro Gln Ser  Gln Ser Ala Thr Ser  Ser Ser Arg 
    1010                 1015                 1020             


Thr Cys  Gly Asn Thr Lys Cys  Ser Asp Thr Asn Ser  Lys Asn Ser 
    1025                 1030                 1035             


Cys Tyr  Ser Gln Thr Asn Ser  Glu Ser Cys Ser Ser  Lys Met Ser 
    1040                 1045                 1050             


Gly Pro  Ser Cys Lys Thr Ala  Asn Ser Gly Ser Arg  Ser Cys Arg 
    1055                 1060                 1065             


Asn Lys  Lys Cys Gln Asp Ser  Ala Thr Glu Asn Ser  Phe His Ser 
    1070                 1075                 1080             


Pro Leu  Thr Asn Pro Leu Ser  Gly Glu Lys Leu Ser  Glu Gln Lys 
    1085                 1090                 1095             


Ser Leu  Asp Leu Val Arg Lys  Asp Lys Glu Ser Ser  His Asp Leu 
    1100                 1105                 1110             


Arg His  Gly Cys Ser Asp Glu  Glu His Asp His Thr  Asn Leu Asp 
    1115                 1120                 1125             


Lys Ala  Tyr Asp Ser Cys Ala  Leu Gln Glu Cys Cys  Tyr Ser Val 
    1130                 1135                 1140             


Gln Gly  Asn Lys Thr Asp Val  Ser Glu Thr Gly Ile  Gln Glu Thr 
    1145                 1150                 1155             


Ala His  Cys Asp Ser Thr Asn  Gln Thr Cys Gln Thr  Ala Ser Ser 
    1160                 1165                 1170             


Gly Ser  Met Thr Cys Gly Asn  Asp Lys Ile Leu Asp  Ser Leu Ser 
    1175                 1180                 1185             


Ile His  Gly Cys His Ser His  Asp Asn Pro Leu His  Glu Glu Asn 
    1190                 1195                 1200             


Asn Leu  Glu Gln Lys Ile Leu  Asp Val Val Gly Glu  Gly Ile Lys 
    1205                 1210                 1215             


Ser Pro  His Ala Val Gly His  Gly Cys Ser Asp Lys  Glu His Asp 
    1220                 1225                 1230             


His Ser  His Pro Glu Lys Ala  Tyr Asp Ser Cys Ala  Thr Asp Asp 
    1235                 1240                 1245             


Cys Cys  Phe Ser Val Gln Val  His Gly Ile Asp Asp  Val Ser Lys 
    1250                 1255                 1260             


Ser Glu  Ile Gln Glu Thr Ala  His Cys Asp Ser Thr  Lys Gln Ser 
    1265                 1270                 1275             


Met Val  Ile Ser Ser Ser Cys  Lys His Glu Pro Lys  Asp Gln Val 
    1280                 1285                 1290             


Asn His  Cys Gly Leu His Ser  Lys Thr Thr Pro Thr  Asp Glu Glu 
    1295                 1300                 1305             


Leu Ala  Lys Leu Val Arg Arg  Cys Cys Lys Tyr Lys  Pro Cys His 
    1310                 1315                 1320             


Asp Val  Arg Ser Gly Cys Arg  Lys His Ala Ala Glu  Cys Gly Pro 
    1325                 1330                 1335             


Thr Val  Arg Ser Thr Ile Asn  Ile Leu Arg Asp Asn  His His His 
    1340                 1345                 1350             


Tyr Leu  Asp Cys Ser Gly Arg  Lys Val Cys Ser Leu  Leu Glu Lys 
    1355                 1360                 1365             


Arg His  Ile Gly Gly Cys Cys  Asp Ser Phe Arg Lys  Glu Cys Cys 
    1370                 1375                 1380             


Ala Lys  Lys Lys His Leu Gly  Ala Ser Phe Gly Gly  Gly Leu Ser 
    1385                 1390                 1395             


Glu Ile  Val Ile Glu 
    1400             


<210>  2
<211>  1444
<212>  PRT
<213>  Nicotiana tabacum

<400>  2

Met Val Glu Ser Glu Lys Met Asn Asp Thr Lys Asn Leu Ser Lys Ser 
1               5                   10                  15      


Tyr Phe Asp Val Leu Gly Ile Cys Cys Thr Ser Glu Val Val Leu Val 
            20                  25                  30          


Glu Lys Ile Leu Lys Asn Leu Glu Gly Val Lys Glu Val Ser Val Ile 
        35                  40                  45              


Val Thr Thr Lys Thr Val Ile Val Ile His Asp Ser Leu Leu Ile Ser 
    50                  55                  60                  


Gln Gln Gln Ile Val Lys Ala Leu Asn Gln Ala Arg Leu Glu Ala Ser 
65                  70                  75                  80  


Ile Arg Val Lys Gly Glu Lys Asn Tyr Gln Lys Lys Trp Pro Ser Pro 
                85                  90                  95      


Phe Ala Ile Gly Ser Gly Ile Leu Leu Gly Leu Ser Phe Leu Lys Tyr 
            100                 105                 110         


Phe Phe Ala Pro Phe Gln Trp Leu Ala Leu Ala Ala Val Ala Val Gly 
        115                 120                 125             


Ile Pro Pro Ile Ile Phe Arg Gly Val Ala Ala Val Arg Asn Leu Thr 
    130                 135                 140                 


Leu Asp Ile Asn Ile Leu Val Leu Ile Ala Val Thr Gly Ser Ile Val 
145                 150                 155                 160 


Leu His Asp Tyr Trp Glu Ala Gly Thr Ile Val Phe Leu Phe Thr Ile 
                165                 170                 175     


Ala Glu Trp Leu Glu Ser Arg Ala Ser His Lys Ala Thr Ala Ala Met 
            180                 185                 190         


Ser Ser Leu Val Asn Ile Val Pro Pro Thr Ala Val Leu Ala Glu Ser 
        195                 200                 205             


Gly Glu Val Val Asn Val Asp Glu Val Lys Leu Asn Ser Ile Leu Ala 
    210                 215                 220                 


Val Lys Ala Gly Glu Thr Ile Pro Ile Asp Gly Val Val Met Glu Gly 
225                 230                 235                 240 


Glu Cys Asp Val Asp Glu Lys Thr Leu Thr Gly Glu Ser Phe Pro Val 
                245                 250                 255     


Ser Lys Gln Ile Asp Ser Thr Val Trp Ala Gly Thr Thr Asn Leu Asn 
            260                 265                 270         


Gly Tyr Ile Ser Val Lys Thr Thr Ala Leu Ala Glu Asp Cys Ala Val 
        275                 280                 285             


Ala Arg Met Ala Gln Leu Val Glu Asp Ala Gln Asn Lys Lys Ser Lys 
    290                 295                 300                 


Thr Gln Arg Tyr Ile Asp Lys Cys Ala Lys Tyr Tyr Thr Pro Ala Ile 
305                 310                 315                 320 


Val Ala Ile Ser Ala Ser Leu Ala Ile Val Pro Thr Ala Leu Arg Val 
                325                 330                 335     


His Asn Arg Asn Glu Trp Tyr Arg Leu Ala Leu Val Thr Leu Val Ser 
            340                 345                 350         


Ala Cys Pro Cys Ala Leu Val Leu Ser Thr Pro Val Ala Met Cys Cys 
        355                 360                 365             


Ala Leu Ser Lys Ala Ala Thr Ser Gly Leu Leu Phe Lys Gly Ala Glu 
    370                 375                 380                 


Tyr Leu Glu Thr Leu Ala Lys Ile Lys Ile Met Ala Phe Asp Lys Thr 
385                 390                 395                 400 


Gly Thr Ile Thr Arg Gly Glu Phe Met Val Thr Glu Phe Lys Ser Leu 
                405                 410                 415     


Val Asp Gly Leu Gly Leu Asn Thr Leu Leu Tyr Trp Val Ser Ser Ile 
            420                 425                 430         


Glu Ser Lys Ser Gly His Pro Met Ala Ala Ala Leu Val Asp Tyr Ala 
        435                 440                 445             


Gln Ser Asn Ser Val Glu Pro Lys Pro Asp Arg Val Glu Gln Phe Gln 
    450                 455                 460                 


Asn Phe Pro Gly Glu Gly Ile Phe Gly Arg Ile Asp Gly Met Glu Ile 
465                 470                 475                 480 


Tyr Val Gly Asn Arg Lys Ile Ser Ser Arg Ala Gly Cys Thr Thr Val 
                485                 490                 495     


Pro Glu Ile Glu Gly Asp Ser Phe Gln Gly Lys Ser Val Gly Tyr Ile 
            500                 505                 510         


Phe Leu Gly Ser Ser Pro Ala Gly Ile Phe Gly Leu Ser Asp Val Cys 
        515                 520                 525             


Arg Ile Gly Val Lys Glu Ala Met Arg Glu Leu Lys Gln Met Gly Ile 
    530                 535                 540                 


Lys Thr Ala Met Leu Thr Gly Asp Cys Tyr Ala Ala Ala Asn His Val 
545                 550                 555                 560 


Gln Asp Gln Leu Gly Gly Ala Met Asp Glu Phe Gln Ala Glu Leu Leu 
                565                 570                 575     


Pro Glu Asp Lys Ala Thr Ile Ile Lys Gly Phe Gln Lys Glu Ala Pro 
            580                 585                 590         


Thr Ala Met Ile Gly Asp Gly Leu Asn Asp Ala Pro Ala Leu Ala Thr 
        595                 600                 605             


Ala Asp Ile Gly Ile Ser Met Gly Ile Ser Gly Ser Ala Leu Ala Lys 
    610                 615                 620                 


Glu Thr Gly His Val Ile Leu Met Thr Asn Asp Ile Gly Arg Ile Pro 
625                 630                 635                 640 


Lys Ala Ala Arg Leu Ala Arg Arg Val Arg Arg Lys Ile Val Glu Asn 
                645                 650                 655     


Met Ile Ile Ser Val Val Thr Lys Ala Ala Ile Val Ala Leu Ala Ile 
            660                 665                 670         


Ala Gly Tyr Pro Leu Val Trp Ala Ala Val Leu Ala Asp Thr Gly Thr 
        675                 680                 685             


Cys Leu Leu Val Ile Leu Asn Ser Met Leu Leu Leu Arg Val Gly Thr 
    690                 695                 700                 


His Arg His Gly Lys Lys Cys Cys Arg Ser Ala Thr Pro Ser His Ala 
705                 710                 715                 720 


Pro Asn His Lys Asp Lys Ala Ser Cys Cys Lys Ser Glu Asn Ala Pro 
                725                 730                 735     


Gln Leu Cys Cys Ser Asp Ile Glu Ser Gln Lys Lys Cys Thr Ser Gln 
            740                 745                 750         


Ser Cys Ser Ser Glu Val Cys Val Pro Arg Cys Gln Pro Val Ser Ser 
        755                 760                 765             


Gly Ser Lys Ser Cys Gly Asn Asn Gln Cys Pro Asp Ser Val Glu Asn 
    770                 775                 780                 


Ser Gly Phe His Ser His Pro Arg Pro Gln Cys Cys Ser Ser Lys Met 
785                 790                 795                 800 


Ala Ser Lys Ala Cys Gln Ser Ala Val Ser Glu Ser Lys Ser Cys Gly 
                805                 810                 815     


Asn Asn Gln Cys Pro Asp Ser Val Glu Asn Ser Gly Phe His Ser His 
            820                 825                 830         


Pro Arg Pro Gln Cys Cys Ser Ser Lys Met Ala Ser Lys Ala Cys Gln 
        835                 840                 845             


Ser Ala Val Ser Glu Ser Lys Ser Cys Gly Asn Asn Gln Cys Pro Asp 
    850                 855                 860                 


Ser Val Glu Asn Ser Gly Phe His Ser His Pro Arg Pro Gln Cys Cys 
865                 870                 875                 880 


Ser Leu Lys Met Ala Ser Lys Ala Cys Gln Ser Ala Val Ser Glu Ser 
                885                 890                 895     


Lys Ser Cys Gly Asn Asn Gln Cys Pro Asp Ser Val Glu Asn Ser Gly 
            900                 905                 910         


Phe His Ser His Pro Arg Pro Gln Cys Cys Ser Ser Lys Met Ala Ala 
        915                 920                 925             


Lys Ala Cys Gln Ser Ala Val Ser Glu Ser Lys Ser Cys Gly Asn Asn 
    930                 935                 940                 


Asn Cys Ser Glu Ser Ile Tyr Lys Ser Ser Cys His Ser Leu Thr Ser 
945                 950                 955                 960 


Ser Leu Val Cys Ser Ser Lys Met Ser Ala Pro Gln Cys His Ser Ala 
                965                 970                 975     


Thr Ser Ser Ser Lys Ser Cys Gly Ser Thr Lys Cys Ser Asn Phe Ser 
            980                 985                 990         


Asp Lys Lys Cys Cys Gln Tyr Asp  Lys Ile Pro Gln Thr  Cys Ser Thr 
        995                 1000                 1005             


Lys Lys  Ser Ala Pro Gly Cys  Gln Ser Ala Val Ser  Gly Ser Lys 
    1010                 1015                 1020             


Ser Cys  Gly Asp Ser Lys Cys  Ser Asp Ser Lys Asp  Asn Ser Ser 
    1025                 1030                 1035             


His Pro  Ser His Pro Asp His  Gln Ile Cys Thr Ser  Lys Leu Cys 
    1040                 1045                 1050             


Ala Pro  Gln Ser Gln Ser Ala  Thr Ser Ser Ser Arg  Thr Cys Gly 
    1055                 1060                 1065             


Asn Met  Lys Cys Ser Asp Thr  Asn Ser Lys Asn Ser  Cys Tyr Ser 
    1070                 1075                 1080             


His Thr  Asn Ser Glu Ser Cys  Ser Ser Lys Met Ser  Gly Pro Ala 
    1085                 1090                 1095             


Cys Lys  Thr Ala Asn Ser Gly  Ser Arg Leu Cys Gly  Asn Lys Lys 
    1100                 1105                 1110             


Cys Leu  Asp Ser Ala Asn Glu  Asn Ser Phe His Ser  Leu Thr Asn 
    1115                 1120                 1125             


Pro Leu  Cys Glu Glu Lys Leu  Leu Glu Lys Glu Ser  Leu Asp Leu 
    1130                 1135                 1140             


Ala Arg  Lys Asp Arg Glu Ser  Asn His Asp Leu Ser  His Gly Cys 
    1145                 1150                 1155             


Ser Asp  Glu Glu His Asp His  Leu Asn Leu Asp Lys  Ala His Asp 
    1160                 1165                 1170             


Ser Cys  Ala Leu Gln Glu Cys  Cys Tyr Ser Val Gln  Gly Asn Lys 
    1175                 1180                 1185             


Thr Asp  Val Ser Glu Thr Gly  Ile Gln Glu Ala Ala  His Cys Asp 
    1190                 1195                 1200             


Ser Ile  Asn Gln Thr Cys Gln  Thr Ala Ile Ser Gly  Ser Met Thr 
    1205                 1210                 1215             


Cys Gly  Asn Asn Lys Ser Leu  Asp Ser Leu Ser Ile  His Gly Cys 
    1220                 1225                 1230             


His Ser  His Asp Ser Pro Leu  His Lys Glu Ser Asn  Leu Glu Gln 
    1235                 1240                 1245             


Lys Ser  Leu Asp Val Ala Gly  Glu Gly Ile Lys Ser  Pro His Ala 
    1250                 1255                 1260             


Val Gly  Gln Gly Cys Ser Asp  Lys Glu His Asn His  Ser His Pro 
    1265                 1270                 1275             


Glu Lys  Ala Tyr Asp Ser Cys  Ala Thr Asp Asp Cys  Cys Phe Ser 
    1280                 1285                 1290             


Val Gln  Val His Gly Ile Asp  Asp Val Ser Arg Ser  Glu Ile Gln 
    1295                 1300                 1305             


Glu Thr  Ala His Cys Asp Ser  Thr Lys Gln Ser Thr  Val Ile Pro 
    1310                 1315                 1320             


Ser Ser  Cys Glu His Glu Pro  Lys Asp Gln Val Asn  His Cys Gly 
    1325                 1330                 1335             


Ser His  Ser Lys Ser Ile Pro  Thr Asp Glu Glu Leu  Ala Lys Leu 
    1340                 1345                 1350             


Val Arg  Arg Cys Cys Lys Tyr  Lys Pro Cys His Asp  Val Arg Ser 
    1355                 1360                 1365             


Gly Cys  Arg Lys His Ala Ala  Glu Cys Gly Pro Thr  Val Arg Ser 
    1370                 1375                 1380             


Thr Ile  Asn Ile Leu Arg Asp  Asn His His His His  Leu Asp Cys 
    1385                 1390                 1395             


Ser Gly  Arg Lys Val Cys Ser  Leu Leu Glu Lys Arg  His Ile Gly 
    1400                 1405                 1410             


Gly Cys  Cys Asp Ser Phe Arg  Lys Glu Cys Cys Ala  Lys Asn Asn 
    1415                 1420                 1425             


His Leu  Gly Ala Ser Phe Gly  Gly Gly Leu Ser Glu  Ile Val Ile 
    1430                 1435                 1440             


Glu 
    


<210>  3
<211>  4246
<212>  DNA
<213>  Nicotiana tabacum

<400>  3
agagaaggag aaaaatggtg gaaagtgaaa aaatgaatga aacaaagaag ttgagcaaga       60

gctattttga tgttttggga atttgctgta cttcagaagt tgttctagtt gaaaaaattc      120

tcaagaatct tgaaggggtt aaagaggttt cagtaattgt cacaacaaag actgtcattg      180

ttattcatga ttctcttctc atttctccgc aacaaattgt taaagcattg aatcaagcaa      240

gattagaagc aagcataaga gtgaaaggag agaaaaacta ccaaaagaaa tggccaagtc      300

catttgcaat tggcagtgga atattgcttg gactctcatt tttgaagtac ttttttgcac      360

ctttccaatg gttagcactt gcagctgttg cagttgggat tcctccaatt atttttagag      420

gtgtggctgc cgtgcgaaac ctcactcttg acatcaacat tcttgtttta atagcagtgg      480

ctggatcaat tgttttacac gattattggg aagctggtac tattgtcttc ttattcgcca      540

ttgcagaatg gctagagtca agggcaagtc acaaggctac cgctgctatg tcatcactgg      600

tcaatatagt ccctccaaca gcagttttag ctgaaagcgg agaagtcgta aatgttgatg      660

aagtcaaggt gaatagcatt cttgctgtga aagctggtga aactatacct attgatggag      720

ttgtagtgga aggggaatgt gacgtggacg agaaaacact gacaggcgag tcgtttccag      780

tttctaagca aagagattca acggtctggg ctggcactac aaatctaaat ggctatatca      840

gtgttaagac tacggctttg gctgaagatt gtgcggtggc taggatggca cagcttgtcg      900

aagatgctca gaacaagaaa tcaaaaaccc aaagatacat cgacaagtgt gctaaatatt      960

atacaccagc aattgtggct atatcagctt ctttggcaat tgttcctact gcattaagag     1020

ttcacaatcg aaatgaatgg tatcgcttgg ctttggtcac attggtgagt gcatgtccgt     1080

gtgcacttgt tctatctaca ccagttgcca tgtgttgcgc actttcaaaa gcagcaacgt     1140

ccggtcttct gtttaaagga gcagagtacc ttgagactct agctaaaatc aaaatcatgg     1200

cttttgacaa aacagggact ataactaaag gagaatttat ggtgaccgag ttcaagtctc     1260

tgattgatgg ttttagtctc aatacactgc tttactgggt ttcaagcatt gagagcaagt     1320

caggtcatcc gatggcagcc gctctggtgg actatgcaca atcaaattcc gttgagccaa     1380

agcctgatag agttgagcag tttcaaaatt ttcctggtga agggatattt ggaagaattg     1440

atggaatgga aatctatgtc gggaatagga aaatttcttc aagagctgga tgtaccacag     1500

taccagaaat agagggtgat agtttcaaag gaaagtctgt tggatacata tttttgggat     1560

catctccagc tggaattttc agtctttccg atgtttgtcg aattggtgta aaagaagcaa     1620

tgagagaact gaagcagatg ggtatcaaaa ccgcgatgct tactggtgat tgttatgcag     1680

ctgccaacca tgtgcaggat cagttaggtg gagctttgga tgaatttcaa gcagaactcc     1740

taccagagga caaggcaaca atcatcaagg gttttcagaa ggaagctcca acagcgatga     1800

taggcgacgg ccttaatgat gctcctgcat tagcaacagc tgacattggc atctcaatgg     1860

gcatctctgg gtcagctctc gctaaagaaa caggccatgt tatactaatg acaaatgaca     1920

tcggaagaat accgaaagct gcacgtcttg ctagaagagt tcgaaggaag attgttgaga     1980

atatgattat atcagtcgtt acaaaggctg ccatagttgc attggcaata gcaggttatc     2040

cattggtttg ggctgctgtc ctcgcagata ctgggacatg cttgctagtg attttgaaca     2100

gcatgctact tctacgagga ggcacacgca gacatgggaa aaaatgttgg agatcttcta     2160

ctccttcgca tgctccccac cacaaagaca aagcttcatg ttgcaagtcg gaaaatgctc     2220

cccagctgtg ttgctctgat attgagtcac aaaagaaatg tacaagtcaa tcatgctcgt     2280

ccgaggtgtg tgttccaaga tgtcaacctg tctcctcagg atcaaagtca tgtggaaata     2340

atcagtgccc agactccatt gaaaatagtg gttttcattc tcatcgccgt cctcaatgct     2400

gctcgtcgaa gatggctgct aaagcatgcc aatctgcagt ttcagaatca aagtcatgcg     2460

gaaataatca gtgcccagac tccgttgaaa atagtggttt tcattctcat ccccgtcctg     2520

aatgctgctc gtcgaagatg gctgctaaag cgtgccaatc tgcagtttca gaatcaaagt     2580

catgtggaaa taatcagtgc ccagactccg ttgaaaatag tggttttcat tctcatcccc     2640

gtcctcaatg ctgttcatcg aagatggctg ctaaagcagg ccaatctgca ctttcagaat     2700

caaagtcatg tggaaataac aattgctcag actccattca caagagtaat tgtcattctt     2760

taactaactc tctagtatgt tcttccaaga tgtctgctcc acaatgtcat tctgctactt     2820

caagcaacaa atcatgtgga agtaccaagt gctccgactt cagtgacaaa aaatgttgtc     2880

aatccgacaa aattcctcaa acgtgctcta ccaagaagtc tgctccagga tgtcaatctg     2940

cagtttctgg gtctaaatca tgtggaaata gcaagtgttc agactcaaaa gacaatagta     3000

gccatccttc acatcccgat catcaaacat gcatgtctaa gttgtgtgct ccacaaagcc     3060

aatctgcaac ttcaagctcc aggacatgtg gaaatacaaa gtgctcggac accaatagca     3120

agaattcttg ttattcacaa accaactctg aatcatgctc ttcaaagatg tctggtccat     3180

catgcaaaac tgctaattca ggttcaaggt catgcagaaa taagaagtgc caggactctg     3240

caaccgagaa cagttttcat tcaccactta ctaatccact cagtggggaa aagctttcgg     3300

agcagaaaag cttggattta gtccgaaaag ataaggaatc aagtcatgat cttcgtcatg     3360

gctgctctga cgaggaacat gatcatacaa atttagacaa ggcatatgac agttgtgcct     3420

tacaagaatg ttgttattcg gttcaaggca ataaaactga tgtatcagaa actggaatcc     3480

aggaaactgc tcattgtgac agcaccaatc aaacatgcca aactgcaagt tcaggatcga     3540

tgacatgcgg aaatgataag atcctggact ctctaagcat ccatggttgt cattcgcatg     3600

ataatccact ccacgaggag aacaacttgg agcagaaaat cttggatgtt gttggagaag     3660

gtataaaatc acctcatgct gtcggtcatg gctgttcgga caaggaacac gatcactcac     3720

atccagaaaa ggcatatgac agttgtgcaa cagatgattg ttgtttttca gttcaagtcc     3780

atggcattga cgacgtatca aaaagtgaaa ttcaagaaac tgctcattgt gacagcacaa     3840

agcagagcat ggtcatctcc agcagctgca aacatgaacc aaaagatcag gtaaatcact     3900

gtggacttca ctctaaaact actccaactg atgaagaact agccaagctg gttagaagat     3960

gctgcaaata caaaccatgc cacgacgtcc gttctggctg caggaagcat gctgcagaat     4020

gtggtccaac cgttcgatca accatcaata tcttacggga caaccatcat cattacctag     4080

actgcagtgg tcgtaaggtt tgttcgctgt tggagaagag acacatcggt ggatgctgtg     4140

acagcttcag aaaagaatgt tgtgccaaga aaaaacacct tggagcaagt tttggaggag     4200

gtttatcaga aattgtcata gagtagatgc aatccgaagt gtacat                    4246


<210>  4
<211>  4376
<212>  DNA
<213>  Nicotiana tabacum

<400>  4
atagaaagaa gagaatggtg gaaagtgaga aaatgaatga cacaaagaat ctgagcaaga       60

gctattttga tgttttggga atttgctgta cttcagaagt tgttcttgtt gaaaaaattc      120

tcaagaatct tgaaggggtt aaagaggttt cagtaattgt cacaacaaag actgtcattg      180

ttattcatga ttctctcctc atttctcagc aacaaattgt taaagcattg aatcaagcaa      240

gattagaagc aagtataaga gtgaaaggag agaaaaacta ccaaaagaaa tggccaagtc      300

catttgcaat tggcagtgga atattgcttg gactctcatt tttgaagtac ttttttgcac      360

ctttccaatg gttagcactt gcagctgttg cagttgggat tcctccaatt atttttaggg      420

gtgtggctgc cgtgcgaaac ctcactcttg acatcaacat tcttgtttta atagcagtga      480

cgggatcaat tgttttacac gattattggg aagctggtac tattgtcttc ttattcacca      540

ttgcagaatg gctagagtca agggcaagtc acaaggctac tgctgctatg tcatcactgg      600

tcaatatagt ccctccaaca gcagttttag ctgaaagtgg agaagtcgta aatgttgatg      660

aagtcaagtt gaatagcatt cttgctgtta aagctggtga aactatacct attgatggag      720

ttgtaatgga aggggaatgt gacgtggacg agaaaacact gacaggcgag tcgtttccag      780

tttctaagca aatagattca acggtctggg ctggcactac aaatctaaat ggctatatca      840

gtgttaagac tacggctttg gctgaagatt gtgcggtggc taggatggcg cagcttgtcg      900

aagatgctca gaacaagaaa tcaaaaaccc aaagatacat tgacaagtgt gctaaatatt      960

atacaccagc aattgtggct atatcagctt ctttggcaat agttcctact gcattaagag     1020

ttcacaatcg aaatgagtgg tatcgcttgg ctttggtcac gttggtgagt gcatgtccgt     1080

gtgcacttgt gctatctaca ccagttgcca tgtgttgtgc actttctaaa gcagcaacgt     1140

ccggtcttct gtttaaagga gcagagtacc ttgagactct tgctaaaatc aaaatcatgg     1200

cttttgacaa aacagggact ataactagag gagaatttat ggtgaccgag ttcaagtctc     1260

tggttgatgg tcttggtctc aatacactgc tttactgggt ttcaagtatt gagagcaagt     1320

caggtcatcc gatggcagcc gctctggttg actatgcaca atcaaattcc gttgagccaa     1380

agcctgatag agttgagcag tttcaaaatt ttcctggtga agggatattt ggaagaattg     1440

atggaatgga aatctatgtc gggaatagga aaatttcttc aagagctgga tgtactacag     1500

taccagaaat agagggtgat agtttccaag gaaagtctgt tggatacata tttttgggat     1560

catctcccgc tggaattttc ggtctttccg atgtttgtcg aattggtgta aaagaagcaa     1620

tgagagagct gaagcagatg ggtatcaaaa ccgcgatgct tactggtgat tgttatgcag     1680

ctgccaacca tgtgcaggat cagttaggtg gagctatgga tgaatttcaa gcggaactct     1740

taccagagga caaggcaaca atcatcaagg gttttcagaa ggaagctcca acagcgatga     1800

taggcgacgg ccttaatgat gctcctgcat tagcaacagc tgacattggc atctcaatgg     1860

gcatctctgg gtcagctctc gcgaaagaaa caggccatgt tatactaatg acaaatgaca     1920

tcggaagaat accaaaagct gcacgtcttg ctagaagagt tcgaaggaag attgttgaga     1980

atatgattat atcagtcgtt acaaaggccg ccatagttgc attggcaata gcaggttatc     2040

cattggtttg ggctgctgtc ctcgcggata ctgggacatg cttgctagtg atcttgaaca     2100

gcatgctact tctacgagta ggcacacaca gacatgggaa aaaatgttgt agatctgcta     2160

ctccttcgca tgctcccaac cacaaagaca aagcttcttg ttgcaagtcg gaaaatgctc     2220

cgcagctgtg ttgctctgat attgagtcac aaaagaaatg tacgagtcaa tcatgctcgt     2280

ccgaggtgtg tgttccaaga tgtcaacctg tctcctcggg atcaaagtca tgtggaaata     2340

atcagtgccc agactccgtt gaaaatagtg gttttcattc tcatccccgt cctcaatgct     2400

gctcgtcgaa gatggcttct aaagcatgcc aatctgcagt ttcagaatca aagtcatgtg     2460

gaaataatca gtgcccagac tccgttgaaa atagtggttt tcattctcat ccccgccctc     2520

aatgctgctc gtctaagatg gcttctaaag catgccaatc tgcagtttca gaatcaaagt     2580

catgtggaaa taatcagtgc ccagactccg ttgaaaatag tggttttcat tctcatcccc     2640

gtcctcaatg ctgctcgttg aagatggctt ctaaagcatg ccaatctgca gtttcagaat     2700

caaagtcatg tggaaataat cagtgcccag actccgttga aaatagtggt tttcattctc     2760

atccccgtcc tcaatgctgc tcgtcgaaga tggctgctaa agcatgccaa tctgcagttt     2820

cagaatcaaa gtcatgtgga aataacaatt gctcggagtc catttacaag agtagttgtc     2880

attctttaac aagttctcta gtatgttctt ccaagatgtc tgctccacaa tgtcattctg     2940

ccacttcaag ctccaaatca tgtggaagta ccaagtgctc caacttcagt gacaaaaaat     3000

gttgccaata tgacaaaatt cctcaaacgt gctctaccaa gaagtctgct ccaggatgtc     3060

aatctgcagt ttctgggtct aaatcatgtg gagatagcaa gtgttcagac tcgaaagaca     3120

atagtagcca tccttcacat cccgatcatc aaatatgcac gtctaagttg tgtgctccac     3180

aaagccaatc tgcaacttca agctccagga catgtggaaa tatgaagtgc tcggacacca     3240

atagcaagaa ttcttgttat tcacatacca actctgaatc atgctcttca aagatgtctg     3300

gtccagcatg caaaactgct aattcaggtt caaggttatg cggaaataag aagtgcctag     3360

actctgcaaa cgagaacagt tttcattcac ttactaatcc actctgtgag gaaaagcttt     3420

tggagaagga aagcttggat ttagcccgaa aagataggga atcaaatcat gatcttagtc     3480

atggttgctc tgacgaggaa catgatcatc taaatttaga caaggcacat gacagttgtg     3540

ccttacaaga atgttgttat tctgttcaag gcaataaaac tgatgtatca gaaactggaa     3600

tccaggaagc tgctcattgt gacagcatca atcaaacatg ccaaactgca atttcaggat     3660

caatgacatg cggaaataat aagagtctgg actctctaag catccatggt tgtcattcac     3720

atgatagtcc actccacaag gagagcaact tggagcagaa aagcttggat gttgctggag     3780

aaggtataaa atcacctcat gctgtcggtc aaggctgttc ggacaaggag cacaatcact     3840

cgcatccaga aaaggcgtat gacagttgtg caacagacga ttgttgtttt tcagttcaag     3900

tccatggcat tgacgacgta tcaagaagtg aaattcaaga aactgctcat tgtgacagca     3960

caaaacagag cacggtcatc cccagcagct gcgaacatga accaaaagat caggtaaatc     4020

actgtggatc tcactctaaa agtattccaa ctgatgaaga actagccaag ctggttagaa     4080

gatgctgcaa atacaaacca tgccacgatg tccgctctgg ctgcaggaag catgctgcag     4140

aatgtggtcc aaccgttcga tcaaccatca atatcttacg ggacaaccat catcatcatc     4200

tagactgcag tggtcgtaag gtttgttcgc tgttggagaa gagacacatt ggtggatgct     4260

gtgacagctt cagaaaagaa tgttgtgcca agaacaatca ccttggagca agttttggag     4320

gaggtttatc agaaattgtc atagagtaga tgcaatctga agtgtacata tgttgt         4376


<210>  5
<211>  191
<212>  DNA
<213>  Nicotiana tabacum

<400>  5
tgagagcaag tcaggtcatc cgatggcagc cgctctggtg gactatgcac aatcaaattc       60

cgttgagcca aagcctgata gagttgagca gtttcaaaat tttcctggtg aagggatatt      120

tggaagaatt gatggaatgg aaatctatgt cgggaatagg aaaatttctt caagagctgg      180

atgtaccaca g                                                           191


<210>  6
<211>  139
<212>  DNA
<213>  Nicotiana tabacum

<400>  6
taaatggttg aatcatttct tatgctcata gtagagataa aacatcagag ttataattat       60

aagtatatga tttctccagt taattttgct gttagatttt ctttgacctg tttagcacta      120

atgcggtgga tgtttgaat                                                   139


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon1 forward primer

<400>  7
gcatgttctt ataagagaaa ctc                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon1 reverse primer

<400>  8
gtgaatttat ttaacaagcc aca                                               23


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon2 forward primer

<400>  9
ccaaaattgt ttctgcttct cc                                                22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon2 reverse primer

<400>  10
cgtcatataa attgggacaa aag                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon4/5 forward primer

<400>  11
gtgtctttat tttctcactg ata                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon4/5 reverse primer

<400>  12
tagtgacgtg attcataaga caa                                               23


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon6 forward primer

<400>  13
atcagtcctt tcacttgacc c                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon6 reverse primer

<400>  14
aaccattaga gccatttcag aa                                                22


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon7/8 forward primer

<400>  15
gatactgcaa tacaaaagca cat                                               23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1-Exon7/8 reverse primer

<400>  16
cacttacttg gtaatacgtt ct                                                22


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon1 forward primer

<400>  17
ttgctactct gggttgctac                                                   20


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon1 reverse primer

<400>  18
tcaagtttaa agtttgcttc tac                                               23


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon2 forward primer

<400>  19
tgtgcataca taacgtaaat cg                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon2 reverse primer

<400>  20
atcaaatacc acataagtag gg                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon4/5 forward primer

<400>  21
tttagtcact ttgacataaa tgg                                               23


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon4/5 reverse primer

<400>  22
aagacagaga acaagttcac at                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon6 forward primer

<400>  23
tcagtccttt cgcttgacct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon6 reverse primer

<400>  24
gagaatgtgg tactcgcaag                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon7/8 forward primer

<400>  25
atacattgag gacacataat cg                                                22


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2-Exon7/8 reverse primer

<400>  26
tataccccat tctgaccctt g                                                 21


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 forward primer

<400>  27
tcatgcagaa ataagaagtg ccag                                              24


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 reverse primer

<400>  28
atggatgctt agagagtcca gga                                               23


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2 forward primer

<400>  29
gttatgcgga aataagaagt gccta                                             25


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2 reverse primer

<400>  30
catggatgct tagagagtcc agac                                              24


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Actin 9 forward primer

<400>  31
ctattctccg ctttggactt ggca                                              24


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Actin 9 reverse primer

<400>  32
aggacctcag gacaacggaa acg                                               23


<210>  33
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 Q293* mutant-probe

<400>  33
aggatggcac agct                                                         14


<210>  34
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 wild type probe

<400>  34
aggatggcac agct                                                         14


<210>  35
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 forward primer

<400>  35
ctggcactac aaatctaaat ggtagtatag tattt                                  35


<210>  36
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 reverse primer

<400>  36
ctggtgtata atatttagca cacttgtcg                                         29


<210>  37
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 E296K mutant-probe

<400>  37
cacagcttgt caaag                                                        15


<210>  38
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 wild type probe

<400>  38
cacagcttgt cgaag                                                        15


<210>  39
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 forward primer

<400>  39
ctggcactac aaatctaaat ggtagtatag tattt                                  35


<210>  40
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 reverse primer

<400>  40
ctggtgtata atatttagca cacttgtcg                                         29


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 T402I mutant-probe

<400>  41
tttgacaaaa cagggatta                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 wild type probe

<400>  42
tttgacaaaa cagggacta                                                    19


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 forward primer

<400>  43
ccatgtgttg cgcactttca                                                   20


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 reverse primer

<400>  44
aactcggtca ccataaattc tcctt                                             25


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 G251D mutant-probe

<400>  45
agaaaacact gacagacg                                                     18


<210>  46
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 wild type probe

<400>  46
aaaacactga caggcg                                                       16


<210>  47
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 forward primer

<400>  47
aagtcgtaaa tgttgatgaa gtcaagg                                           27


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 reverse primer

<400>  48
cagcccagac cgttgaatct c                                                 21


<210>  49
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 V351M mutant-probe

<400>  49
ctttggtcac attgatga                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 wild type probe

<400>  50
ttggtcacat tggtgagt                                                     18


<210>  51
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 forward primer

<400>  51
ggctatatca gcttctttgg caatt                                             25


<210>  52
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 reverse primer

<400>  52
aacacatggc aactggtgta gataga                                            26


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.1 G382R mutant-probe

<400>  53
ttctgtttaa aagagcagag                                                   20


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 wild type probe

<400>  54
tctgtttaaa ggagcagagt a                                                 21


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 forward primer

<400>  55
ccatgtgttg cgcactttca                                                   20


<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.1 reverse primer

<400>  56
aactcggtca ccataaattc tcctt                                             25


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2 W265* mutant-probe

<400>  57
atagattcaa cggtctagg                                                    19


<210>  58
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 wild type probe

<400>  58
ttcaacggtc tgggc                                                        15


<210>  59
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 forward primer

<400>  59
ggtgaaacta tacctattga tggagttgta a                                      31


<210>  60
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 reverse primer

<400>  60
cactaaataa atgaagcatg aaggaatact ac                                     32


<210>  61
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA4.2 Q561* mutant-probe

<400>  61
caaccatgtg taggat                                                       16


<210>  62
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 wild type probe

<400>  62
tgccaaccat gtgcag                                                       16


<210>  63
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 forward primer

<400>  63
ttggtgtaaa agaagcaatg agagag                                            26


<210>  64
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMA 4.2 reverse primer

<400>  64
atcatttcag cgtattgcag aattt                                             25


