                         SEQUENCE LISTING

<110>  CSL Behring Recombinant Facility AG
 
<120>  Recombinant IgG Fc Multimers

<130>  2016_L001_A257

<150>  EP2016152867
<151>  2016-01-27

<150>  EP2016162166
<151>  2016-03-24

<150>  EP2016195116
<151>  2016-10-21


<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thrs Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu 
225                 230                 235                 240 


Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
                245                 250 


<210>  2
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Cys His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu 
225                 230                 235                 240 


Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
                245                 250 


<210>  3
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  6
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  7
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr Leu Tyr Asn 
                245                 250                 255     


Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            260                 265                 


<210>  8
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Cys His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr Leu Tyr Asn 
                245                 250                 255     


Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            260                 265                 


<210>  9
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  9
gagcccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc tgaactgctg       60

ggcggaccta gcgtgttcct gttcccccca aagcccaagg acaccctgat gatctcccgg      120

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttt      180

aattggtacg tggacggcgt ggaagtgcat aacgccaaga ccaagcccag agaggaacag      240

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc      360

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc ccctagcagg      420

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaagggctt ctaccccagc      480

gacattgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagagc      600

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      660

tacacccaga agtcactgag cctgagcccc ggcaagccca ccctgtacaa tgtgtccctc      720

gtgatgagcg acaccgccgg cacctgttac                                       750


<210>  10
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  10
gagcccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc tgaactgctg       60

ggcggaccta gcgtgttcct gttcccccca aagcccaagg acaccctgat gatctcccgg      120

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttt      180

aattggtacg tggacggcgt ggaagtgcat aacgccaaga ccaagcccag agaggaacag      240

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgt gccaccagga ctggctgaac      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc      360

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc ccctagcagg      420

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaagggctt ctaccccagc      480

gacattgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagagc      600

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      660

tacacccaga agtcactgag cctgagcccc ggcaagccca ccctgtacaa tgtgtccctc      720

gtgatgagcg acaccgccgg cacctgttac                                       750


