                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> MUTANT GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) 
      COMPOSITIONS AND METHODS OF TREATING CANCER

<130> P13350-02

<140>
<141>

<150> 62/280,987
<151> 2016-01-20

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 1
atggggaagg tgaaggtcgg agtcaacgga tttggtcgtt ttgggcgcct ggtcaccagg       60

gctgctttta actctggtaa agtggatatt gttgccatca atgacccctt cattgacctc      120

aactacatgg tttacatgtt ccaatatgat tccacccatg gcaaattcca tggcaccgtc      180

aaggctgaga acgggaagct tgtcatcaat ggaaatccca tcaccatctt ccaggagcga      240

gatccctcca aaatcaagtg gggcgatgct ggcgctgagt acgtcgtgga gtccactggc      300

gtcttcacca ccatggagaa ggctggggct catttgcagg ggggagccaa aagggtcatc      360

atctctgccc cctctgctga tgcccccatg ttcgtcatgg gtgtgaacca tgagaagtat      420

gacaacagcc tcaagatcat cagcaatgcc tcctggacca ccaactggtt agcacccctg      480

gccaaggtca tccatgacaa ctttggtatc gtggaaggac tcatgaccac agtccttgcc      540

atcactgcca cccagaagac tgtggatggc ccctccggga aactgtggcg tgatggccgc      600

ggggctctcc agaacatcat ccctgcctct actggcgctg ccaaggctgt gggcaaggtc      660

atccctgagc tgaacgggaa gctcactggc atggccttcc gtgtccccac tgccaacgtg      720

tcagtggtgg acctgacctg ccgtctagaa aaacctgcca aatatgatga catcaagaag      780

gtggtgaagc aggcgtcgga gggccccctc aagggcatcc tgggctacac tgagcaccag      840

gtggtctcct ctgacttcaa cagcgacacc cactcctcca cctttgacgc tggggctggc      900

attgccctca acgaccactt tgtcaagctc atttcctggt atgacaagga atttggctac      960

agcaacaggg tggtggacct catggcccac atggcctcca aggagtaa                  1008


<210> 2
<211> 335
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210> 3
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 3
atggggaagg tgaaggtcgg agtcaacgga tttggtcaaa ttgggcgcct ggtcaccagg       60

gctgctttta actctggtaa agtggatatt gttgccatca atgacccctt cattgacctc      120

aactacatgg tttacatgtt ccaatatgat tccacccatg gcaaattcca tggcaccgtc      180

aaggctgaga acgggaagct tgtcatcaat ggaaatccca tcaccatctt ccaggagcga      240

gatccctcca aaatcaagtg gggcgatgct ggcgctgagt acgtcgtgga gtccactggc      300

gtcttcacca ccatggagaa ggctggggct catttgcagg ggggagccaa aagggtcatc      360

atctctgccc cctctgctga tgcccccatg ttcgtcatgg gtgtgaacca tgagaagtat      420

gacaacagcc tcaagatcat cagcaatgcc tcctggacca ccaactggtt agcacccctg      480

gccaaggtca tccatgacaa ctttggtatc gtggaaggac tcatgaccac agtccttgcc      540

atcactgcca cccagaagac tgtggatggc ccctccggga aactgtggcg tgatggccgc      600

ggggctctcc agaacatcat ccctgcctct actggcgctg ccaaggctgt gggcaaggtc      660

atccctgagc tgaacgggaa gctcactggc atggccttcc gtgtccccac tgccaacgtg      720

tcagtggtgg acctgacctg ccgtctagaa aaacctgcca aatatgatga catcaagaag      780

gtggtgaagc aggcgtcgga gggccccctc aagggcatcc tgggctacac tgagcaccag      840

gtggtctcct ctgacttcaa cagcgacacc cactcctcca cctttgacgc tggggctggc      900

attgccctca acgaccactt tgtcaagctc atttcctggt atgacaagga atttggctac      960

agcaacaggg tggtggacct catggcccac atggcctcca aggagtaa                  1008


<210> 4
<211> 335
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Gln Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210> 5
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 5
atggggaagg tgaaggtcgg agtcaacgga tttggtcaaa ttgggcgcct ggtcaccagg       60

gctgctttta actctggtaa agtggatatt gttgccatca atgacccctt cattgaactc      120

aactacatgg tttacatgtt ccaatatgat tccacccatg gcaaattcca tggcaccgtc      180

aaggctgaga acgggaagct tgtcatcaat ggaaatccca tcaccatctt ccaggagcga      240

gatccctcca aaatcaagtg gggcgatgct ggcgctgagt acgtcgtgga gtccactggc      300

gtcttcacca ccatggagaa ggctggggct catttgcagg ggggagccaa aagggtcatc      360

atctctgccc cctctgctga tgcccccatg ttcgtcatgg gtgtgaacca tgagaagtat      420

gacaacagcc tcaagatcat cagcaatgcc tcctggacca ccaactggtt agcacccctg      480

gccaaggtca tccatgacaa ctttggtatc gtggaaggac tcatgaccac agtccttgcc      540

atcactgcca cccagaagac tgtggatggc ccctccggga aactgtggcg tgatggccgc      600

ggggctctcc agaacatcat ccctgcctct actggcgctg ccaaggctgt gggcaaggtc      660

atccctgagc tgaacgggaa gctcactggc atggccttcc gtgtccccac tgccaacgtg      720

tcagtggtgg acctgacctg ccgtctagaa aaacctgcca aatatgatga catcaagaag      780

gtggtgaagc aggcgtcgga gggccccctc aagggcatcc tgggctacac tgagcaccag      840

gtggtctcct ctgacttcaa cagcgacacc cactcctcca cctttgacgc tggggctggc      900

attgccctca acgaccactt tgtcaagctc atttcctggt atgacaagga atttggctac      960

agcaacaggg tggtggacct catggcccac atggcctcca aggagtaa                  1008


<210> 6
<211> 335
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Glu Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210> 7
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tcaacggatt tggtcaattt gggcgcctgg tca                                    33


<210> 8
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tgaccaggcg cccaaattga ccaaatccgt tga                                    33


<210> 9
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
aatgacccct tcattagact caactacatg gtt                                    33


<210> 10
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
aaccatgtag ttgagtctaa tgaaggggtc att                                    33


<210> 11
<211> 45
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(45)

<400> 11
atg ggg aag gtg aag gtc gga gtc aac gga ttt ggt cgt att ggg             45
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly               
1               5                   10                  15                


<210> 12
<211> 15
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly 
1               5                   10                  15  


<210> 13
<211> 45
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(45)

<400> 13
atg ggg aag gtg aag gtc gga gtc aac gga ttt ggt caa att ggg             45
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Gln Ile Gly               
1               5                   10                  15                


<210> 14
<211> 15
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Gln Ile Gly 
1               5                   10                  15  


<210> 15
<211> 45
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(45)

<400> 15
gtt gcc atc aat gac ccc ttc att gac ctc aac tac atg gtt tac             45
Val Ala Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr               
1               5                   10                  15                


<210> 16
<211> 15
<212> PRT
<213> Homo sapiens

<400> 16
Val Ala Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr 
1               5                   10                  15  


<210> 17
<211> 45
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(45)

<400> 17
gtt gcc atc aat gac ccc ttc att gaa ctc aac tac atg gtt tac             45
Val Ala Ile Asn Asp Pro Phe Ile Glu Leu Asn Tyr Met Val Tyr               
1               5                   10                  15                


<210> 18
<211> 15
<212> PRT
<213> Homo sapiens

<400> 18
Val Ala Ile Asn Asp Pro Phe Ile Glu Leu Asn Tyr Met Val Tyr 
1               5                   10                  15  


<210> 19
<211> 221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atgctcaaga tcatcagcaa tgcctcctgc accaccaact gcttagcacc cctggccaag       60

gtcatccatg acaactttgg tatcgtggaa ggactcatga ccacagtcca tgccatcact      120

gcacccagaa gactgtggat ggcccctccg ggaaactgtg gcgtgatggc cgcggggctc      180

tccagaacat catccctgcc tctactggcg ctgccaagta a                          221


<210> 20
<211> 316
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atgctcaaga tcatcagcaa tgcctcctgc accaccaact gcttagcacc cctggccaag       60

gtcatccatg acaactttgg tatcgtggaa ggactcatga ccacagtcca tgccatcact      120

gcacccagaa gactgtggat ggcccctccg ggaaactgtg gcgtgatggc cgcggggctc      180

tccagaacat catccctgcc tctactggcg ctgccaaggc tgtgggcaag gtcatccctg      240

agctgaacgg aagctcactg gcatggcctt ccgtgtcccc actgccaacg tgtcagtggt      300

ggacctgacc tgctaa                                                      316


<210> 21
<211> 37
<212> DNA
<213> Homo sapiens

<400> 21
gatttggtcg tattgggcgc ctggtcacca gggctgc                                37


<210> 22
<211> 37
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 22
gatttggtcn aattgggcgc ctggtcacca gggctgc                                37


<210> 23
<211> 37
<212> DNA
<213> Homo sapiens

<400> 23
tgaccccttc attgacctca actacatggt ttacatg                                37


<210> 24
<211> 37
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 24
tgaccccttc attgnactca actacatggt ttacatg                                37


<210> 25
<211> 216
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
ctcaagatca tcagcaatgc ctcctgcacc accaactgct tagcacccct ggccaaggtc       60

atccatgaca actttggtat cgtggaagga ctcatgacca cagtccatgc catcactgcc      120

acccagaaga ctgtggatgg cccctccggg aaactgtggc gtgatggccg cggggctctc      180

cagaacatca tccctgcctc tactggcgct gccaag                                216


<210> 26
<211> 72
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro 
1               5                   10                  15      


Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met 
            20                  25                  30          


Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro 
        35                  40                  45              


Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile 
    50                  55                  60                  


Pro Ala Ser Thr Gly Ala Ala Lys 
65                  70          


<210> 27
<211> 312
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
ctcaagatca tcagcaatgc ctcctgcacc accaactgct tagcacccct ggccaaggtc       60

atccatgaca actttggtat cgtggaagga ctcatgacca cagtccatgc catcactgcc      120

acccagaaga ctgtggatgg cccctccggg aaactgtggc gtgatggccg cggggctctc      180

cagaacatca tccctgcctc tactggcgct gccaaggctg tgggcaaggt catccctgag      240

ctgaacggga agctcactgg catggccttc cgtgtcccca ctgccaacgt gtcagtggtg      300

gacctgacct gc                                                          312


<210> 28
<211> 104
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro 
1               5                   10                  15      


Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met 
            20                  25                  30          


Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro 
        35                  40                  45              


Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile 
    50                  55                  60                  


Pro Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu 
65                  70                  75                  80  


Leu Asp Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn 
                85                  90                  95      


Val Ser Val Val Asp Leu Thr Cys 
            100                 


