                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Pecot, Chad
       Cox, Adrienne
       Der, Channing
 
<120>  METHODS AND COMPOSITIONS USING RNA INTERFERENCE FOR INHIBITION OF
        KRAS

<130>  5470-773WO

<150>  US 62/280,458
<151>  2016-01-19

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  1
gagcuuauga cguaggcaa                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  2
aguuggagcu uaugacgua                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  3
gguaguugga gcuuaugac                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  4
guaguuggag cuuaugacg                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  5
uaguuggagc uuaugacgu                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  6
guuggagcuu augacguag                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  7
uuggagcuua ugacguagg                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  8
uggagcuuau gacguaggc                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  9
ggagcuuaug acguaggca                                                    19


<210>  10
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  10
gagcuuauga cguaggcaan n                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  11
aguuggagcu uaugacguan n                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  12
gguaguugga gcuuaugacn n                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  13
guaguuggag cuuaugacgn n                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  14
uaguuggagc uuaugacgun n                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  15
guuggagcuu augacguagn n                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  16
uuggagcuua ugacguaggn n                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  17
uggagcuuau gacguaggcn n                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  18
ggagcuuaug acguaggcan n                                                 21


<210>  19
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  19
uugccuacgu cauaagcuc                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  20
uacgucauaa gcuccaacu                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  21
gucauaagcu ccaacuacc                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  22
cgucauaagc uccaacuac                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  23
acgucauaag cuccaacua                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  24
cuacgucaua agcuccaac                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  25
ccuacgucau aagcuccaa                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  26
gccuacguca uaagcucca                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence

<400>  27
ugccuacguc auaagcucc                                                    19


<210>  28
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  28
uugccuacgu cauaagcucn n                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  29
uacgucauaa gcuccaacun n                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  30
gucauaagcu ccaacuaccn n                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  31
cgucauaagc uccaacuacn n                                                 21


<210>  32
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  32
acgucauaag cuccaacuan n                                                 21


<210>  33
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  33
cuacgucaua agcuccaacn n                                                 21


<210>  34
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  34
ccuacgucau aagcuccaan n                                                 21


<210>  35
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  35
gccuacguca uaagcuccan n                                                 21


<210>  36
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA sequence


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is dT

<400>  36
ugccuacguc auaagcuccn n                                                 21


<210>  37
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  37
actgaatata aacttgtggt agttggagct tatgacgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  38
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  38
actgaatata aacttgtggt agttggagct tttgacgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  39
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  39
actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  40
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  40
actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  41
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  41
actgaatata aacttgtggt agttggagct tgtggcgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  42
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  42
actgaatata aacttgtggt agttggagct gatggcgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  43
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  43
actgaatata aacttgtggt agttggagct gttggcgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  44
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated human KRAS gene sequence

<400>  44
actgaatata aacttgtggt agttggagct ggtgacgtag gcaagagtgc cttgacgata       60

cag                                                                     63


<210>  45
<211>  63
<212>  RNA
<213>  Artificial

<220>
<223>  Mutated siRNA target sequence


<220>
<221>  misc_feature
<222>  (22)..(40)
<223>  G12C siRNA target sequence

<400>  45
acugaauaua aacuuguggu aguuggagcu uguggcguag gcaagagugc cuugacgaua       60

cag                                                                     63


<210>  46
<211>  63
<212>  RNA
<213>  Artificial

<220>
<223>  Mutated siRNA target sequence


<220>
<221>  misc_feature
<222>  (22)..(40)
<223>  G12D siRNA target sequence

<400>  46
acugaauaua aacuuguggu aguuggagcu gauggcguag gcaagagugc cuugacgaua       60

cag                                                                     63


<210>  47
<211>  63
<212>  RNA
<213>  Artificial

<220>
<223>  Mutated siRNA target sequence


<220>
<221>  misc_feature
<222>  (18)..(36)
<223>  12CD13D_4 siRNA target sequence

<220>
<221>  misc_feature
<222>  (19)..(37)
<223>  12CD13D_A target sequence

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  12CD13D_B target sequence

<220>
<221>  misc_feature
<222>  (21)..(39)
<223>  12CD13D_2 siRNA target sequence

<220>
<221>  misc_feature
<222>  (22)..(40)
<223>  12CD13D_C target sequence

<220>
<221>  misc_feature
<222>  (23)..(41)
<223>  12CD13D_D target sequence

<220>
<221>  misc_feature
<222>  (24)..(42)
<223>  12CD13D_E target sequence

<220>
<221>  misc_feature
<222>  (25)..(43)
<223>  12CD13D_F target sequence

<220>
<221>  misc_feature
<222>  (26)..(44)
<223>  12CD13D_1 siRNA target sequence

<220>
<221>  misc_feature
<222>  (28)..(46)
<223>  12CD13D_3 siRNA target sequence

<400>  47
acugaauaua aacuuguggu aguuggagcu uaugacguag gcaagagugc cuugacgaua       60

cag                                                                     63


<210>  48
<211>  63
<212>  RNA
<213>  Artificial

<220>
<223>  Mutated siRNA target sequence


<220>
<221>  misc_feature
<222>  (21)..(39)
<223>  12CV13D_1 siRNA target sequence

<220>
<221>  misc_feature
<222>  (26)..(44)
<223>  12CV13D_2 siRNA target sequence

<400>  48
acugaauaua aacuuguggu aguuggagcu uuugacguag gcaagagugc cuugacgaua       60

cag                                                                     63


<210>  49
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Negative control siRNA sequence

<400>  49
uucuccgaac gugucacgu                                                    19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Positive control siRNA sequence

<400>  50
gucucuugga uauucucga                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Positive control siRNA sequence

<400>  51
cagcuaauuc agaaucauu                                                    19


