                   
<110>  PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
 
<120>  Anticuerpos Monoclonales especficos para el antgeno pIII de 
       Adenovirus humano (ADV), producidos y secretados por hibridomas 
       celulares, tiles para la deteccin y el diagnstico de la 
       infeccin causada por ADV

<130>  W 2017/9447

<150>  CL 201600164
<151>  2016-01-21

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  203
<212>  PRT
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 7E11 - anti pIII VH

<400>  1

Met Glu Cys Ser Trp Val Ile Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Val Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Leu Gly Gln Gly Asp Val Tyr Trp Phe Phe Asp Val Trp Gly 
        115                 120                 125             


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Leu Lys Thr Leu Gly Glu Phe Phe Phe Phe Gly 
145                 150                 155                 160 


Trp Gly Gly Gly Gly Gly Ala Asn Pro Pro Leu Arg Gly Pro Ala Pro 
                165                 170                 175     


Arg His Arg Arg Thr Ser Thr Arg Pro Leu Val Gln Ser Cys Thr Ile 
            180                 185                 190         


Ile Asp Phe Arg Cys Gln Ala Ala Glu Leu Met 
        195                 200             


<210>  2
<211>  128
<212>  PRT
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 7E11 - anti pIII VL

<400>  2

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 
        35                  40                  45              


Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ile Arg Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
        115                 120                 125             


<210>  3
<211>  612
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 7E11 - anti pIII VH

<400>  3
atggaatgca gctgggtcat cctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccagctgc aacagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaagactt ctggatacac attcactgaa tacaccatgc actgggtgaa gcagagccat      180

ggacagagcc ttgagtggat tggaggtatt aatcctaaca atggtggtac taggtacaac      240

cagaacttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      300

gagctccgca gcctgacatc tgaagtctat tactgtgcaa gactgggaca aggggacgtg      360

tactggttct tcgatgtctg gggcgcaggg accacggtca ccgtctcctc agccaaaacg      420

acacccccat ccgtttatcc cttggccctg aaaactttgg gggaattttt tttttttggg      480

tggggggggg gggggggggc taaccccccc ctacgtggtc ctgcgcccag acatcgaaga      540

accagtacac gtccccttgt ccagtcttgc acaataatag acttcagatg tcaggctgcg      600

gagctcatgt ag                                                          612


<210>  4
<211>  387
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 7E11 - anti pIII VL

<400>  4
atggagtcag acacactgct gttatgggta ctgctgctct gggttccagg ttccactggt       60

gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc      120

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      180

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      360

tcggaggggg gaccaagctg gaaataa                                          387


<210>  5
<211>  180
<212>  PRT
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 6F11 - anti pIII VH

<400>  5

Met Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
1               5                   10                  15      


Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
            20                  25                  30          


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile 
        35                  40                  45              


Tyr Pro Asn Asn Gly Gly Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys 
    50                  55                  60                  


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
65                  70                  75                  80  


Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Leu 
                85                  90                  95      


Gly Gln Gly Asp Val His Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Ile Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Leu Lys Asn Leu Gly Lys Lys Gly Leu Ser Ala Trp Ala Pro 
    130                 135                 140                 


Gly Thr Leu Gly Lys Pro Ile Thr Trp Val Leu Arg Pro Lys His Gln 
145                 150                 155                 160 


Lys Pro Met His Val Pro Leu Ser His Leu Ala Gln Ile Ile Asp Cys 
                165                 170                 175     


Lys Ser Ser Met 
            180 


<210>  6
<211>  145
<212>  PRT
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 6F11 - anti pIII VL

<400>  6

Met Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            20                  25                  30          


Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
65                  70                  75                  80  


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu 
                85                  90                  95      


Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Tyr Ser Lys Ala Trp Glu Lys Gly 
        115                 120                 125             


Ala Ala Leu Val Leu Arg Asn Arg Arg Lys Thr Lys Arg Pro Pro Pro 
    130                 135                 140                 


Pro 
145 


<210>  7
<211>  543
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 6F11 - anti pIII VH

<400>  7
atgcaacagt ctggacctga gctggtgaag cctggggctt cagtgaagat atcctgcaag       60

acttctggat acacattcac tgaatacacc atacactggg tgaagcagag ccatggaaag      120

agccttgagt ggattggagg tatttatcct aacaatggtg gtactaagta caaccagaag      180

ttcaagggca aggccacatt gactgtagac aagtcttcca gcacagccta catggagctc      240

cgcagcctta catctgagga ttctgcagtc tattattgtg caagactggg acaaggggac      300

gtgcattggt tcttcgatgt ctggggcgca gggaccacgg tcatcgtctc ctcagccaaa      360

acgacacccc catccgttta tcccttggcc ctgaaaaacc ttgggaaaaa aggtttatcc      420

gcctgggccc ctggaacctt gggaaaaccc attacgtggg tcctgcgccc caaacatcaa      480

aaaccaatgc acgtcccctt gtcccatctt gcacaaataa tagactgcaa atcctcaatg      540

taa                                                                    543


<210>  8
<211>  438
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Hibridoma 6F11 - anti pIII VL

<400>  8
atggtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc       60

tcatacaggg ccagcaaaag tgtcagtaca tctggctata gttatatgca ctggaaccaa      120

cagaaaccag gacagccacc cagactcctc atctatcttg tatccaacct agaatctggg      180

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcaccctcaa catccatcct      240

gtggaggagg aggatgctgc aacctattac tgtcagcaca ttagggagct tacacgttcg      300

gaggggggac caagctggaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tacagtaaag cttgggaaaa gggggcggca ttggttctga ggaaccggcg taaaaccaaa      420

aggccccccc ccccttaa                                                    438


<210>  9
<211>  33
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Nucletidos del partidor MulgkVL5'-B

<400>  9
gggaattcat ggagacagac acactcctgc tat                                    33


<210>  10
<211>  39
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Nucletidos del partidor MuIgkVL5'-C

<400>  10
actagtcgac atggagwcag acacactsct gytatgggt                              39


<210>  11
<211>  33
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Nucletidos del partidor MuIgVH5'-A

<400>  11
gggaattcat grasttskgg ytmarctkgr ttt                                    33


<210>  12
<211>  35
<212>  DNA
<213>  Secuencia artificial
<220> 
<223>  Sinttica - Nucletidos del partidor MuIgVH5'-F

<400>  12
actagtcgac atgaacttyg ggytsagmtt grttt                                  35


